Jennifer Doudna | Academic Influence

Why Is Jennifer Doudna Influential?

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Areas of Specialization: Biochemistry, Molecular Biology
Jennifer Doudna is a Li Ka Shing Chancellor Chair Professor for the Department of Chemistry and Department of Molecular and Cell Biology at the University of California, Berkeley. In addition, she has been a professor at the University of California, San Francisco and an investigator with the Howard Hughes Medical Institute and senior investigator at the Gladstone Institutes. She earned a B.A. in biochemistry from Pomona College and a Ph.D. in biological chemistry and molecular pharmacology from Harvard Medical School.

She is best known for her work with CRISPR. She, along with her colleague Emmanuelle Charpentier, were the first to suggest that genes could be edited or reprogrammed, now considered one of the most impactful discoveries ever made in the field of biology.

For her work in gene editing, she has received numerous prestigious awards, including the Breakthrough Prize in Life Sciences, the Gruber Prize in Genetics, the Kavli Prize in Nanoscience and in 2016, she was runner-up for the Time magazine Person of the Year, alongside her fellow CRISPR colleagues.

She is a member of the National Academy of Sciences, the American Academy of Arts and Sciences, the National Academy of Medicine and the National Academy of Inventors. Doudna has been awarded the LUI Che Woo Prize for Welfare Betterment and, in 2020, earned the Nobel Prize in Chemistry, alongside Emmanuelle Charpentier, “for the development of a method for genome editing.”

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According to Wikipedia, Jennifer Anne Doudna is an American biochemist who has done pioneering work in CRISPR gene editing, and made other fundamental contributions in biochemistry and genetics. Doudna was one of the first women to share a Nobel in the sciences. She received the 2020 Nobel Prize in Chemistry, with Emmanuelle Charpentier, "for the development of a method for genome editing." She is the Li Ka Shing Chancellor's Chair Professor in the Department of Chemistry and the Department of Molecular and Cell Biology at the University of California, Berkeley. She has been an investigator with the Howard Hughes Medical Institute since 1997.

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Jennifer Doudna's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Papers

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity (2012) (11192)
The new frontier of genome engineering with CRISPR-Cas9 (2014) (4222)
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression (2013) (3592)
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes (2013) (2744)
RNA-programmed genome editing in human cells (2013) (1839)
RNA-guided genetic silencing systems in bacteria and archaea (2012) (1569)
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9 (2014) (1417)
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity (2018) (1396)
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity (2013) (1277)
Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing (1996) (1188)
CRISPR-Cas9 Structures and Mechanisms. (2017) (958)
Structural Basis for Double-Stranded RNA Processing by Dicer (2006) (940)
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation (2014) (920)
Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery (2014) (884)
Molecular mechanisms of RNA interference. (2013) (824)
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering (2016) (821)
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy (2017) (736)
CRISPR-Cas guides the future of genetic engineering (2018) (731)
A three-dimensional view of the molecular machinery of RNA interference (2009) (721)
Crystal structure of a hepatitis delta virus ribozyme (1998) (715)
The chemical repertoire of natural ribozymes (2002) (651)
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection (2016) (632)
Applications of CRISPR technologies in research and beyond (2016) (621)
Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease (2010) (597)
A prudent path forward for genomic engineering and germline gene modification (2015) (547)
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins (2015) (536)
Structural basis for CRISPR RNA-guided DNA recognition by Cascade (2011) (516)
Programmable RNA recognition and cleavage by CRISPR/Cas9 (2014) (493)
Hepatitis C Virus IRES RNA-Induced Changes in the Conformation of the 40S Ribosomal Subunit (2001) (491)
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes (2018) (480)
Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair (2017) (460)
In vitro reconstitution of the human RISC-loading complex (2008) (439)
Conformational control of DNA target cleavage by CRISPR–Cas9 (2015) (430)
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. (2009) (426)
RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions (2011) (424)
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage (2016) (416)
Programmable RNA Tracking in Live Cells with CRISPR/Cas9 (2016) (408)
A Cas9–guide RNA complex preorganized for target DNA recognition (2015) (400)
Crystal structure of the ribonucleoprotein core of the signal recognition particle. (2000) (390)
New CRISPR-Cas systems from uncultivated microbes (2016) (381)
Mechanism of ribosome recruitment by hepatitis C IRES RNA. (2001) (372)
Expanding the Biologist's Toolkit with CRISPR-Cas9. (2015) (372)
Cas1–Cas2 complex formation mediates spacer acquisition during CRISPR–Cas adaptive immunity (2014) (364)
Structures of the RNA-guided surveillance complex from a bacterial immune system (2011) (364)
Multiplexed RNA structure characterization with selective 2′-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq) (2011) (360)
Adaptive strategies of the influenza virus polymerase for replication in humans (2009) (358)
THE PROMISE AND CHALLENGE OF THERAPEUTIC GENOME EDITING (2020) (345)
Cornerstones of CRISPR–Cas in drug discovery and therapy (2017) (335)
RNA Tertiary Structure Mediation by Adenosine Platforms (1996) (328)
Insights into RNA structure and function from genome-wide studies (2014) (328)
Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy (2020) (323)
Structural determinants of RNA recognition and cleavage by Dicer (2007) (305)
Structural Roles for Human Translation Factor eIF3 in Initiation of Protein Synthesis (2005) (289)
Dynamics of CRISPR-Cas9 genome interrogation in living cells (2015) (283)
Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity (2015) (271)
A magnesium ion core at the heart of a ribozyme domain (1997) (265)
Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity. (2013) (263)
Ribozyme structures and mechanisms. (2000) (261)
Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity (2020) (250)
Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3 (2008) (250)
RNA targeting by the type III-A CRISPR-Cas Csm complex of Thermus thermophilus. (2014) (247)
A conformational switch controls hepatitis delta virus ribozyme catalysis (2004) (246)
Rational design of a split-Cas9 enzyme complex (2015) (245)
Ribonuclease revisited: structural insights into ribonuclease III family enzymes. (2007) (244)
Structural and mechanistic insights into hepatitis C viral translation initiation (2007) (242)
Disabling Cas9 by an anti-CRISPR DNA mimic (2017) (241)
Structural insights into RNA Processing by the Human RISC-Loading Complex (2009) (240)
Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated genome defense. (2009) (239)
A universal mode of helix packing in RNA (2001) (236)
Mechanism of foreign DNA selection in a bacterial adaptive immune system. (2012) (232)
Autoinhibition of human dicer by its internal helicase domain. (2008) (227)
Clades of huge phages from across Earth’s ecosystems (2019) (220)
Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes (2017) (216)
CRISPR-CasΦ from huge phages is a hypercompact genome editor (2020) (214)
Structure and activity of the RNA-targeting Type III-B CRISPR-Cas complex of Thermus thermophilus. (2013) (209)
Cap-Independent Translation Is Required for Starvation-Induced Differentiation in Yeast (2007) (206)
Metal-binding sites in the major groove of a large ribozyme domain. (1996) (205)
eIF3d is an mRNA cap-binding protein required for specialized translation initiation (2016) (203)
The hepatitis C virus internal ribosome entry site adopts an ion-dependent tertiary fold. (1999) (203)
RNA-catalysed synthesis of complementary-strand RNA (1989) (194)
Tunable protein synthesis by transcript isoforms in human cells (2015) (193)
Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA. (2004) (189)
RNA processing enables predictable programming of gene expression (2012) (189)
Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesis. (2015) (188)
Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing (2013) (188)
CRISPR-Cpf1 mediates efficient homology-directed repair and temperature-controlled genome editing (2017) (186)
CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference (2014) (186)
A specific monovalent metal ion integral to the AA platform of the RNA tetraloop receptor (1998) (185)
Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9 (2016) (184)
RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes. (2017) (181)
An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3 (2011) (180)
Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation (2002) (179)
A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9 (2017) (178)
Precise and Heritable Genome Editing in Evolutionarily Diverse Nematodes Using TALENs and CRISPR/Cas9 to Engineer Insertions and Deletions (2013) (177)
Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling. (2015) (177)
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy Please share how this access benefits you. Your story matters (2018) (174)
Use of cis- and trans-ribozymes to remove 5' and 3' heterogeneities from milligrams of in vitro transcribed RNA. (1996) (173)
An inhibitory activity in human cells restricts the function of an avian-like influenza virus polymerase. (2008) (164)
A Broad-Spectrum Inhibitor of CRISPR-Cas9 (2017) (164)
Nucleosome breathing and remodeling constrain CRISPR-Cas9 function (2016) (162)
Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System (2015) (161)
Direct Link between RACK1 Function and Localization at the Ribosome In Vivo (2008) (158)
CasX enzymes comprise a distinct family of RNA-guided genome editors (2019) (157)
Biotechnology: Rewriting a genome (2013) (156)
Foreign DNA capture during CRISPR–Cas adaptive immunity (2015) (154)
Crystallization of RNA and RNA-protein complexes. (2004) (153)
ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing (2016) (152)
Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch (2016) (152)
RNA-based recognition and targeting: sowing the seeds of specificity (2017) (150)
Coupled 5' nucleotide recognition and processivity in Xrn1-mediated mRNA decay. (2011) (147)
Mechanism of substrate selection by a highly specific CRISPR endoribonuclease. (2012) (144)
Ribozyme catalysis: not different, just worse (2005) (143)
The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor (2011) (142)
Crystallization and structure determination of a hepatitis delta virus ribozyme: use of the RNA-binding protein U1A as a crystallization module. (2000) (142)
High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding (2017) (141)
siRNA repositioning for guide strand selection by human Dicer complexes. (2011) (139)
Structural insights into the signal recognition particle. (2003) (137)
dsRNA with 5′ overhangs contributes to endogenous and antiviral RNA silencing pathways in plants (2009) (137)
Systematic discovery of natural CRISPR-Cas12a inhibitors (2018) (136)
Substrate-specific kinetics of Dicer-catalyzed RNA processing. (2010) (136)
Structure and Function of the Eukaryotic Ribosome The Next Frontier (2002) (135)
Structural Characterization of the Human Eukaryotic Initiation Factor 3 Protein Complex by Mass Spectrometry*S (2007) (133)
TRBP alters human precursor microRNA processing in vitro. (2012) (132)
Structural genomics of RNA (2000) (130)
A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells. (2016) (129)
Large-scale purification of a stable form of recombinant tobacco etch virus protease. (2001) (127)
The structural biology of CRISPR-Cas systems. (2015) (124)
Reconsidering movement of eukaryotic mRNAs between polysomes and P bodies. (2011) (122)
Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning (2015) (122)
RNA-dependent RNA targeting by CRISPR-Cas9 (2018) (122)
Specificity for aminoacylation of an RNA helix: an unpaired, exocyclic amino group in the minor groove. (1991) (121)
CRISPR Immunological Memory Requires a Host Factor for Specificity. (2016) (121)
The j-Subunit of Human Translation Initiation Factor eIF3 Is Required for the Stable Binding of eIF3 and Its Subcomplexes to 40 S Ribosomal Subunits in Vitro* (2004) (119)
CRISPR germline engineering—the community speaks (2015) (118)
Modeling and automation of sequencing-based characterization of RNA structure (2011) (118)
eIF3j is located in the decoding center of the human 40S ribosomal subunit. (2007) (117)
Reassortment and Mutation of the Avian Influenza Virus Polymerase PA Subunit Overcome Species Barriers (2011) (117)
Crystal structure of the HCV IRES central domain reveals strategy for start-codon positioning. (2011) (115)
Cutting it close: CRISPR-associated endoribonuclease structure and function. (2015) (112)
A thermostable Cas9 with increased lifetime in human plasma (2017) (112)
Multiple sensors ensure guide strand selection in human RNAi pathways. (2013) (112)
Hepatitis C Virus Internal Ribosome Entry Site (IRES) Stem Loop IIId Contains a Phylogenetically Conserved GGG Triplet Essential for Translation and IRES Folding (2000) (111)
The new frontier of genome engineering with CRISPR-Cas 9 GENOME (2014) (111)
A general module for RNA crystallization. (1998) (110)
Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation (2010) (109)
Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3) (2011) (109)
CRISPR-CasX is an RNA-dominated enzyme active for human genome editing (2019) (105)
Structures of the CRISPR genome integration complex (2017) (104)
Mass spectrometric analysis of the human 40S ribosomal subunit: Native and HCV IRES‐bound complexes (2005) (103)
Mutations in CIC and FUBP1 Contribute to Human Oligodendroglioma (2011) (101)
Specificity of RNA–RNA helix recognition (2002) (101)
Structure of Dicer and mechanistic implications for RNAi. (2006) (100)
Metal ions in ribozyme folding and catalysis. (2000) (98)
A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis. (1991) (98)
Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs (2018) (97)
Receptor‐Mediated Delivery of CRISPR‐Cas9 Endonuclease for Cell Type Specific Gene Editing (2018) (97)
Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity (2014) (96)
Structural and energetic analysis of RNA recognition by a universally conserved protein from the signal recognition particle. (2001) (96)
RNA folds: insights from recent crystal structures. (1999) (94)
5 Translation Initiation by Viral Internal Ribosome Entry Sites (2007) (94)
Substrate-specific structural rearrangements of human Dicer (2013) (94)
Widespread Translational Remodeling during Human Neuronal Differentiation. (2017) (92)
A bacterial Argonaute with noncanonical guide RNA specificity (2016) (91)
Structural Insights into Group II Intron Catalysis and Branch-Site Selection (2002) (90)
A nested double pseudoknot is required for self-cleavage activity of both the genomic and antigenomic hepatitis delta virus ribozymes. (1999) (90)
Self-assembly of a group I intron active site from its component tertiary structural domains. (1995) (90)
Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA (2012) (90)
Direct pK(a) measurement of the active-site cytosine in a genomic hepatitis delta virus ribozyme. (2001) (89)
Unconventional miR-122 binding stabilizes the HCV genome by forming a trimolecular RNA structure (2013) (87)
RNA structure, not sequence, determines the 5' splice-site specificity of a group I intron. (1989) (87)
The chemistry of Cas9 and its CRISPR colleagues (2017) (85)
Native Tandem and Ion Mobility Mass Spectrometry Highlight Structural and Modular Similarities in Clustered-Regularly-Interspaced Shot-Palindromic-Repeats (CRISPR)-associated Protein Complexes From Escherichia coli and Pseudomonas aeruginosa* (2012) (84)
Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain (2017) (82)
Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules (2019) (82)
Crystallization of ribozymes and small RNA motifs by a sparse matrix approach. (1993) (82)
Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes. (2015) (81)
Stereochemical course of catalysis by the Tetrahymena ribozyme. (1989) (81)
Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases (2013) (80)
Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering. (2016) (80)
Structural insights into RNA interference. (2010) (80)
RNA-guided assembly of Rev-RRE nuclear export complexes (2014) (79)
Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor. (1995) (79)
The HCV IRES pseudoknot positions the initiation codon on the 40S ribosomal subunit. (2010) (79)
Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner. (2018) (78)
An essential GTPase promotes assembly of preribosomal RNA processing complexes. (2005) (76)
Guide-bound structures of an RNA-targeting A-cleaving CRISPR–Cas13a enzyme (2017) (76)
Ribozyme structures and mechanisms. (2001) (75)
Rapid assessment of SARS-CoV-2 evolved variants using virus-like particles (2021) (75)
Coordinated activities of human dicer domains in regulatory RNA processing. (2012) (74)
Broad-spectrum enzymatic inhibition of CRISPR-Cas12a (2019) (73)
The stem-loop binding protein forms a highly stable and specific complex with the 3' stem-loop of histone mRNAs. (2001) (72)
RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a. (2018) (71)
RNA–protein analysis using a conditional CRISPR nuclease (2013) (69)
Assembly of an active group II intron-maturase complex by protein dimerization. (2004) (68)
SRP RNA provides the physiologically essential GTPase activation function in cotranslational protein targeting. (2006) (68)
CRISPR–Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV–host factor interactions (2018) (68)
RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System (2017) (66)
Hepatitis C virus 3′UTR regulates viral translation through direct interactions with the host translation machinery (2013) (64)
Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants (2022) (64)
A Unified Resource for Tracking Anti-CRISPR Names. (2018) (63)
Applications of CRISPR-Cas Enzymes in Cancer Therapeutics and Detection. (2018) (63)
Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation (2013) (62)
Deciphering Off-Target Effects in CRISPR-Cas9 through Accelerated Molecular Dynamics (2019) (62)
Protecting genome integrity during CRISPR immune adaptation (2016) (60)
Author response: Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery (2014) (60)
DNA Targeting by a Minimal CRISPR RNA-Guided Cascade. (2016) (60)
The P5abc peripheral element facilitates preorganization of the tetrahymena group I ribozyme for catalysis. (2000) (60)
DNA capture by a CRISPR-Cas9–guided adenine base editor (2020) (59)
Mutational analysis of conserved nucleotides in a self-splicing group I intron. (1990) (59)
Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery (2017) (58)
Structural roles of monovalent cations in the HDV ribozyme. (2007) (57)
Assembly of an exceptionally stable RNA tertiary interface in a group I ribozyme. (1999) (57)
Functional Overlap between eIF4G Isoforms in Saccharomyces cerevisiae (2010) (56)
Genome-resolved metagenomics reveals site-specific diversity of episymbiotic CPR bacteria and DPANN archaea in groundwater ecosystems (2021) (55)
Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress (2016) (55)
ATP-independent diffusion of double-stranded RNA binding proteins (2012) (54)
Genomes in Focus: Development and Applications of CRISPR-Cas9 Imaging Technologies. (2018) (54)
Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles (2021) (54)
Controlling and enhancing CRISPR systems (2020) (54)
Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3* (2015) (53)
Key role of the REC lobe during CRISPR–Cas9 activation by ‘sensing’, ‘regulating’, and ‘locking’ the catalytic HNH domain (2018) (52)
Temperature-responsive competitive inhibition of CRISPR-Cas9 (2018) (52)
THE P4-P6 DOMAIN DIRECTS HIGHER ORDER FOLDING OF THE TETRAHYMENA RIBOZYME CORE (1997) (50)
Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination (2022) (49)
Machine learning predicts new anti-CRISPR proteins (2019) (48)
Species- and site-specific genome editing in complex bacterial communities (2021) (48)
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification (2019) (48)
Rapid assessment of SARS-CoV-2–evolved variants using virus-like particles (2021) (47)
RNA-mediated interaction between the peptide-binding and GTPase domains of the signal recognition particle (2005) (47)
Accelerated RNA detection using tandem CRISPR nucleases (2021) (45)
Massively parallel kinetic profiling of natural and engineered CRISPR nucleases (2019) (43)
Mutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune Response. (2017) (42)
The NIH Somatic Cell Genome Editing program (2021) (42)
GTP-dependent formation of a ribonucleoprotein subcomplex required for ribosome biogenesis. (2006) (41)
Structural and energetic analysis of metal ions essential to SRP signal recognition domain assembly. (2002) (41)
RNA seeing double: close-packing of helices in RNA tertiary structure. (1997) (39)
Targeted delivery of CRISPR-Cas9 and transgenes enables complex immune cell engineering (2021) (38)
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling (2020) (38)
Chemical synthesis of oligoribonucleotides containing 2-aminopurine: substrates for the investigation of ribozyme function. (1990) (37)
Ribozyme-catalyzed primer extension by trinucleotides: a model for the RNA-catalyzed replication of RNA. (1993) (37)
Limited cross-variant immunity after infection with the SARS-CoV-2 Omicron variant without vaccination (2022) (36)
CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks (2020) (36)
Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes (2019) (35)
Template-directed primer extension catalyzed by the Tetrahymena ribozyme. (1991) (35)
Miniribozymes, small derivatives of the sunY intron, are catalytically active (1989) (34)
Engineering of Monosized Lipid-Coated Mesoporous Silica Nanoparticles for CRISPR Delivery. (2020) (34)
Genome-editing revolution: My whirlwind year with CRISPR (2015) (33)
Distinct contributions of KH domains to substrate binding affinity of Drosophila P-element somatic inhibitor protein. (2005) (33)
Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex (2016) (33)
Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a (2019) (33)
Preparation of homogeneous ribozyme RNA for crystallization. (1997) (32)
Blueprint for a pop-up SARS-CoV-2 testing lab (2020) (32)
Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2 (2019) (31)
A Host of Factors Regulating Influenza Virus Replication (2010) (31)
The P4-P6 domain directs higher order folding of the Tetrahymena ribozyme core. (1997) (31)
DNA recognition by an RNA-guided bacterial Argonaute (2017) (30)
Site-Specific Bioconjugation through Enzyme-Catalyzed Tyrosine–Cysteine Bond Formation (2020) (30)
RNA structure: crystal clear? (1997) (30)
New tools provide a second look at HDV ribozyme structure, dynamics and cleavage (2014) (29)
Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity. (2010) (29)
A scoutRNA Is Required for Some Type V CRISPR-Cas Systems. (2020) (28)
Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies (2016) (28)
Identification and analysis of U5 snRNA variants in Drosophila. (2005) (28)
Genomic engineering and the future of medicine. (2015) (27)
Targeted Genome Editing of Bacteria Within Microbial Communities (2020) (27)
Accelerated RNA detection using tandem CRISPR nucleases (2021) (27)
Programmable RNA recognition using a CRISPR-associated Argonaute (2017) (27)
Emerging themes in RNA folding. (1997) (27)
Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble (2019) (26)
The parallel universe of RNA folding (1998) (26)
Candidate Phyla Radiation Roizmanbacteria From Hot Springs Have Novel and Unexpectedly Abundant CRISPR-Cas Systems (2019) (25)
Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas 9 (2016) (24)
The pathway of HCV mRNA recruitment to the human ribosome (2009) (24)
Hepatitis C Virus IRES RNA—Induced Changes in the Conformation of the 40S (2001) (24)
Solving large RNA structures by X-ray crystallography. (2000) (24)
Perspective: Embryo editing needs scrutiny (2015) (23)
Methods in Enzymology. The use of CRISPR/Cas9, ZFNs, and TALENs in generating site-specific genome alterations. Preface. (2014) (23)
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation (2020) (23)
A fast and efficient procedure to produce scFvs specific for large macromolecular complexes. (2007) (22)
A Functional Mini-Integrase in a Two-Protein-type V-C CRISPR System. (2019) (21)
Direct detection of SARS-CoV-2 using CRISPR-Cas13a and a mobile phone (2020) (21)
Molecular Biology: Principles and Practice (2011) (20)
Kinetic analysis of Cas12a and Cas13a RNA-Guided nucleases for development of improved CRISPR-Based diagnostics (2021) (20)
Genome editing: the end of the beginning (2015) (19)
Launching a saliva-based SARS-CoV-2 surveillance testing program on a university campus (2021) (18)
Methods to Crystallize RNA (2000) (18)
CRISPR-Cas9 bends and twists DNA to read its sequence (2021) (18)
Enhancement of hepatitis C viral RNA abundance by precursor miR-122 molecules (2013) (18)
Genetic dissection of an RNA enzyme. (1987) (17)
Spacer Acquisition Rates Determine the Immunological Diversity of the Type II CRISPR-Cas Immune Response. (2019) (17)
Structural biology of CRISPR–Cas immunity and genome editing enzymes (2022) (16)
DNA interference states of the hypercompact CRISPR-CasΦ effector. (2021) (16)
Human Molecular Genetics and Genomics - Important Advances and Exciting Possibilities. (2021) (16)
Comprehensive deletion landscape of CRISPR-Cas9 identifies minimal RNA-guided DNA-binding modules (2020) (15)
An unusual case of pseudo-merohedral twinning in orthorhombic crystals of Dicer. (2007) (14)
Mechanisms of internal ribosome entry in translation initiation. (2001) (14)
Quantitative studies of ribosome conformational dynamics (2007) (14)
CRISPR-Cas12a target binding unleashes single-stranded DNase activity (2017) (14)
Optimizing COVID-19 control with asymptomatic surveillance testing in a university environment (2020) (14)
A Nobel Prize for genetic scissors (2020) (13)
Hammerhead ribozyme structure: U-turn for RNA structural biology. (1995) (13)
Distinct sites of phosphorothioate substitution interfere with folding and splicing of the Anabaena group I intron. (2004) (13)
Quantification of Cas9 binding and cleavage across diverse guide sequences maps landscapes of target engagement (2020) (13)
Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage (2020) (12)
The use of CRISPR/Cas9, ZFNs, TALENs in generating site specific genome alterations (2014) (12)
Chemical biology at the crossroads of molecular structure and mechanism (2005) (12)
Guided Tour to the Heart of RISC (2012) (11)
Evolutionarily Conserved Roles of the Dicer Helicase Domain in Regulating RNA Interference Processing* (2014) (11)
Analog sensitive chemical inhibition of the DEAD‐box protein DDX3 (2016) (11)
Conserved but nonessential interaction of SRP RNA with translation factor EF-G. (2004) (11)
RNA-binding and HEPN nuclease activation are decoupled in CRISPR-Cas13a (2017) (11)
Engineering improved Cas13 effectors for targeted post-transcriptional regulation of gene expression (2021) (10)
Advances in Genome Editing (2016) (10)
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression (2021) (10)
1 1 2 Enhanced proofreading governs CRISPR-Cas 9 targeting accuracy 3 4 (2017) (9)
Establishing Suitability of RNA Preparations for Crystallization (1997) (9)
CRISPR's unwanted anniversary (2019) (9)
Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles (2022) (9)
RNA Scanning of a Molecular Machine with a Built-in Ruler. (2017) (9)
Borgs are giant extrachromosomal elements with the potential to augment methane oxidation (2021) (9)
Reactions to the National Academies/Royal Society Report on Heritable Human Genome Editing. (2020) (9)
Widespread translational remodeling during human neuronal differentiation (2017) (9)
Ribozymes: The hammerhead swings into action (1998) (9)
Knocking out barriers to engineered cell activity (2020) (9)
Rapid detection of SARS-CoV-2 with Cas13 (2020) (9)
Key role of the REC lobe during CRISPR-Cas9 activation by 'sensing', 'regulating', and 'locking' the catalytic HNH domain. (2018) (9)
Optimizing COVID-19 control with asymptomatic surveillance testing in a university environment (2021) (8)
Rapid, point-of-care molecular diagnostics with Cas13 (2020) (8)
Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity. (2022) (8)
Optimized High-Throughput Screen for Hepatitis C Virus Translation Inhibitors (2011) (8)
Robotic RNA extraction for SARS-CoV-2 surveillance using saliva samples (2021) (7)
CRISPR-Cas : a laboratory manual (2016) (7)
Structural coordination between active sites of a CRISPR reverse transcriptase-integrase complex (2021) (7)
Molecular mechanism of off-target effects in CRISPR-Cas9 (2018) (7)
A phosphoramidate substrate analog is a competitive inhibitor of the Tetrahymena group I ribozyme. (2000) (7)
Author response: RNA-programmed genome editing in human cells (2013) (7)
Ro’s Role in RNA Reconnaissance (2005) (7)
Synthesis of Multi-Protein Complexes through Charge-Directed Sequential Activation of Tyrosine Residues. (2021) (7)
A functional map of HIV-host interactions in primary human T cells (2022) (7)
High-throughput biochemical profiling reveals Cas9 off-target binding and unbinding heterogeneity (2016) (7)
Rapid detection of SARS-CoV-2 RNA in saliva via Cas13. (2022) (7)
Diverse ATPase Proteins in Mobilomes Constitute a Large Potential Sink for Prokaryotic Host ATP (2021) (6)
A CRISPR-Cas9–integrase complex generates precise DNA fragments for genome integration (2021) (6)
Creative catalysis: pieces of the RNA world jigsaw. (2001) (6)
A naturally DNase-free CRISPR-Cas12c enzyme silences gene expression (2021) (6)
Reply to Nathamgari et al.: Nanopore electroporation for intracellular delivery of biological macromolecules (2019) (5)
Robotic RNA extraction for SARS-CoV-2 surveillance using saliva samples (2021) (5)
Huge and variable diversity of episymbiotic CPR bacteria and DPANN archaea in groundwater ecosystems (2020) (5)
Get in LINE: Competition for Newly Minted Retrotransposon Proteins at the Ribosome. (2015) (5)
Resource Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression (2013) (4)
Inhibition of CRISPR-Cas 9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC 2 (2019) (4)
5 Catalytic Strategies of Self-Cleaving Ribozymes: Relics of an RNA World? (2006) (4)
HEPATITIS DELTA VIRUS RIBOZYME (1999) (4)
Author Correction: Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity (2020) (4)
A sparse matrix approach to crystallizing ribozymes and RNA motifs. (1997) (4)
Establishing suitability of RNA preparations for crystallization. Determination of polydispersity. (1997) (4)
Voices of biotech (2016) (4)
Nucleic acids and their protein partners. (2008) (3)
Resource Programmable RNA Tracking in Live Cells with CRISPR / Cas 9 Graphical (2016) (3)
Sensitive and multiplexed RNA detection with Cas13 droplets and kinetic barcoding (2021) (3)
CRISPR–Cas9-mediated nuclear transport and genomic integration of nanostructured genes in human primary cells (2022) (3)
CRISPR-RNAa: targeted activation of translation using dCas13 fusions to translation initiation factors (2022) (3)
How Will Kinetics and Thermodynamics Inform Our Future Efforts to Understand and Build Biological Systems? (2017) (3)
CRISPR-Cas9 mediated nuclear transport and genomic integration of nanostructured genes in human primary cells (2021) (3)
Activating silent Argonautes (2013) (3)
IGI-LuNER: single-well multiplexed RT-qPCR test for SARS-CoV-2 (2020) (3)
Methods and compositions for RNA-directed target DNA modification and for RNA-directed transcription modulation (2013) (3)
Borgs are giant genetic elements with potential to expand metabolic capacity (2022) (3)
RNA structure: A molecular contortionist (1997) (3)
Identifying RNA contacts from SHAPE-MaP by partial correlation analysis (2014) (2)
Ribosomes: Cashing in on crystals (1999) (2)
Chemical Synthesis of Oligoribonucleotides Containing 2‐Aminopurine: Substrates for the Investigation of Ribozyme Function. (1991) (2)
RNA-targeting CRISPR-Cas13 Provides Broad-spectrum Phage Immunity (2022) (2)
Protein–nucleic Acid Interactions Editorial Overview (2)
Decorating chromatin for enhanced genome editing using CRISPR-Cas9 (2022) (2)
Supplemental Information RNA Targeting by the Type IIIA CRISPR-Cas Csm Complex of Thermus thermophilus (2014) (2)
Rewriting the Code of Life: CRISPR Technology and Its Impact on the Future of Humanity (2017) (2)
RNAs regulate biology. (2006) (2)
Author Correction: CasX enzymes comprise a distinct family of RNA-guided genome editors (2019) (2)
Comprar Molecular Biology. Principles And Practice (International Student Edition) | Michael O'Donnell | 9781464102257 | W.H. Freeman (2011) (2)
A CRISPR-Cas9 Genome Engineering Platform in Primary CD4+ T Cells for the Interrogation of HIV Host Factors (2017) (2)
LuNER: Multiplexed SARS-CoV-2 detection in clinical swab and wastewater samples (2021) (2)
Candidate Phyla Radiation Roizmanbacteria from hot springs have novel, unexpectedly abundant, and potentially alternatively functioning CRISPR-Cas systems (2018) (2)
Hammering out the shape of a ribozyme. (1994) (2)
Treatment of Genetic Diseases With CRISPR Genome Editing. (2022) (1)
Conformational Dynamics of Cas9 during DNA Binding (2017) (1)
CRISPR/CAS FACES THE BIOETHICS SPOTLIGHT (2015) (1)
Meeting Report: The Allied Genetics Conference 2016 (2016) (1)
Perspective: Embryo editing needs scrutiny: Genome-editing presents many opportunities. But the advent of human-germline editing brings urgency to ethical discussions, says jennifer doudna. (2015) (1)
Protein-nucleic acid interactions: unlocking mysteries old and new. (2005) (1)
Lawrence Berkeley National Laboratory Recent Work Title RNA-dependent RNA targeting by CRISPR-Cas 9 Permalink (2018) (1)
Protein-Nucleic Acid Interactions III (2014) (1)
Author response: Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies (2016) (1)
RNA: primed for packing? (2004) (1)
Spotlight: A Conversation with Laura Kiessling and Jennifer Doudna. (2018) (1)
Structural coordination between active sites of a Cas6-reverse transcriptase-Cas1—Cas2 CRISPR integrase complex (2020) (1)
Real-Time Observation of DNA Recognition by the RNA-Guided Endonuclease Cas9 using Single-Molecule FRET (2015) (1)
Crystal structure the Escherichia coli Cas1-Cas2 complex bound to protospacer DNA and Mg (2015) (1)
RNA-catalysed synthesis of complementary strand RNA (1989) (1)
Crystal structure of an RNA/DNA strand exchange junction (2022) (1)
The Dicer-TRBP Interface Structure and Implications for Strand Selection During Microrna Biogenesis (2014) (1)
Site-Specific Generation of Protein-Protein Conjugates Using Native Amino Acids (2019) (1)
Corrigendum to "Engineering of monosized lipid-coated mesoporous silica nanoparticles for CRISPR delivery" Acta Biomaterialia (2020), 114, 358-368. (2020) (1)
Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases (2021) (1)
Native and HCV IRES-bound complexes Mass spectrometric analysis of the human 40 S ribosomal subunit : (2005) (1)
STRUCTURE OF THE RIBONUCLEOPROTEIN CORE OF THE E. COLI SIGNAL RECOGNITION PARTICLE (2000) (1)
Correction: RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System (2017) (1)
Diverse virus-encoded CRISPR-Cas systems include streamlined genome editors (2022) (1)
Cell type-programmable genome editing with enveloped delivery vehicles (2022) (1)
Structural Characterization and Identification of Post‐Translational Modifications of Human Eukaryotic Initiation Factor 3 (eIF3) by FTICR Mass Spectrometry (2006) (1)
A Second Look at the HDV Ribozyme Structure and Dynamics. (2014) (1)
Conserved features of TERT promoter duplications reveal an activation mechanism that mimics hotspot mutations in cancer (2022) (1)
Crystal structure of the active catalytic core of the human DEAD-box protein DDX3 (2015) (0)
Crystal structure of the fluoroacetyl-CoA-specific thioesterase, FlK (2010) (0)
Crystal Structure of Dicer from Giardia intestinalis (2006) (0)
Structure A of CRISPR endoribonuclease Cse3 bound to 19 nt RNA (2011) (0)
Gene editing: CRISPR book review - Doudna responds. (2017) (0)
The Right Chemistry: an Updated Nucleic Acids Textbook (2007) (0)
Single-Molecule Observation of Viral DNA Targeting by CRISPR/Cas Immune Systems (2013) (0)
Defending the Genome: Regulatory RNA in Humans and Bacteria (2013) (0)
Life sciences, philanthropy, information science, space science (2001) (0)
Global landscape of the host response to SARS-CoV-2 variants reveals viral evolutionary trajectories (2022) (0)
Jinek Bacterial Immunity Guided DNA Endonuclease in Adaptive − A Programmable Dual-RNA (2013) (0)
Crystal structure the Escherichia coli Cas1-Cas2 complex bound to protospacer DNA with splayed ends (2015) (0)
Trbp Sliding Promotes Dicer's Cleavage Activity (2012) (0)
Crystal structure of the active catalytic core of the human DEAD-box protein DDX3 bound to AMPPNP (2015) (0)
X-ray crystal structure of human cyclic GMP-AMP synthase (cGAS) (2013) (0)
Template-directed primer extension catalyzed by the Tetrahymena ribozyme (1991) (0)
Crystal structure of the Dicer-TRBP interface (2014) (0)
A Conversation with Jennifer Doudna. (2015) (0)
Attachment of a 32P-phosphate to the 3' Terminus of a DNA Oligonucleotide. (2020) (0)
Single-molecule analysis of DNA interrogation by Cas9 and Cas12a on supercoiled DNA (2022) (0)
The NAI Fellow Profile: An Interview with Dr. Jennifer Doudna (2019) (0)
Jennifer Doudna and Emmanuelle Charpentier’s Experiment About the CRISPR/cas 9 System’s Role in Adaptive Bacterial Immunity (2012) (2017) (0)
Erratum: Molecular Mechanisms of RNA Interference (2020) (0)
Cas6 (TTHB231) product complex (2013) (0)
Rna-guided nucleic acid modifying enzymes and methods of use thereof (2017) (0)
Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Precursor, with C75U mutaion, in Imidazole and Sr2+ solution (2004) (0)
6.04 – RNA Structures Determined by X-ray Crystallography (1999) (0)
of human Dicer-binding proteins and PACT in small RNA processing. (2013) (0)
Cryo-EM structure of CasPhi-2 (Cas12j) bound to crRNA and DNA (2021) (0)
Structure of the SpCas9 DNA adenine base editor - ABE8e (2020) (0)
Crystal Structure of the Yeast Orthologue of RACK1, Asc1. (2009) (0)
Cryo-EM structure of CasPhi-2 (Cas12j) bound to crRNA (2021) (0)
Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Precursor, with C75U mutaion, in Cobalt Hexammine solution (2004) (0)
X-ray crystal structure of Marinitoga piezophila Argonaute in complex with 5' OH guide RNA and target DNA (2017) (0)
CryoEM structure of AcrIIA2 in complex with CRISPR-Cas9 (2019) (0)
Crystal structure of Xrn1-substrate complex (2011) (0)
Cas6 (TTHA0078) substrate mimic complex (2013) (0)
Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Precursor, with C75U mutaion, in EDTA solution (2004) (0)
Hepatitis Delta Virus Gemonic Ribozyme Precursor, with Mg2+ Bound (2004) (0)
Cas6 (TTHA0078) product complex (2013) (0)
Hepatitis Delta Virus ribozyme precursor structure, with C75U mutation, bound to Tl+ and cobalt hexammine (Co(NH3)63+) (2007) (0)
Plat Single Molecule Fluorescence Imaging at Micromolar Concentrations (2012) (0)
CRISPR System: From Adaptive Immunity to Genome Editing (2017) (0)
Structure of eukaryotic translation initiation factor 3 subunit D (eIF3d) cap binding domain from Nasonia vitripennis, Crystal form 3 (2016) (0)
Preliminary in vitro functional analysis of the DEAD‐box protein DDX3 (2012) (0)
Crystal structure of Mn-bound S.pyogenes Cas9 (2014) (0)
Crystal Structure of a Mutant (C109G,G212C) P4-P6 Domain of the Group I Intron from Tetrahymena Thermophilia (2002) (0)
Author response: CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks (2020) (0)
Biology 1A - Lecture 9: Introduction to Bioenergetics (2010) (0)
Crystal structure of anemone STING (Nematostella vectensis) in complex with 3',3' c-di-AMP, c[A(3',5')pA(3',5')p] (2015) (0)
Cas1-Cas2 bound to full-site mimic (2017) (0)
Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Product with C75U Mutaion, cleaved in Imidazole and Mg2+ solutions (2004) (0)
FREE with your next issue of TiBS: A Trends Guide to Proteomics (2001) (0)
Crystal structure of the PABC-TNRC6C complex (2010) (0)
Crystal structure of catalytically-active Streptococcus pyogenes Cas9 in complex with single-guide RNA at 2.9 Angstrom resolution (2015) (0)
Casz compositions and methods of use (2018) (0)
Crystal structure of catalytically-active Streptococcus pyogenes CRISPR-Cas9 in complex with single-guided RNA and double-stranded DNA primed for target DNA cleavage (2016) (0)
Crystal structure of anemone STING (Nematostella vectensis) in apo 'unrotated' closed conformation (2015) (0)
CasX-gRNA-DNA(30bp) State II (2019) (0)
CRISPR's Second Decade: Jennifer Doudna Looks Forward and Back (2022) (0)
Recognition Particle Crystal Structure of the Ribonucleoprotein Core of the Signal (2013) (0)
Structural Basis for Foreign DNA Integration in CRISPR Adaptive Immunity (2014) (0)
Crystal structure of a C75U mutant Hepatitis Delta Virus ribozyme precursor, in Cu2+ solution (2004) (0)
Forum: CRISPR roundtable with Doudna and Liu (2020) (0)
Crystal structure of the active catalytic core of the human DEAD-box protein DDX3 bound to AMP (2015) (0)
Structure of eukaryotic translation initiation factor 3 subunit D (eIF3d) cap binding domain from Nasonia vitripennis, Crystal form 2 (2016) (0)
3 – RNA Structures Determined by X-ray Crystallography (2001) (0)
Cashing in on crystals. (1999) (0)
Tertiary Motifs in RNA Structure and Folding (1999) (0)
RNAPrimed for Packing (2004) (0)
Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase in complex with linear intermediate 5' pppA(3',5')pG (2014) (0)
Hepatitis Delta Virus gemonic ribozyme precursor with C75U mutation and bound to monovalent cation Tl (2007) (0)
Structural Basis for RNA Processing by Dicer (2006) (0)
Cryo-EM structure of CasPhi-2 (Cas12j) bound to crRNA and Phosphorothioate-DNA (2021) (0)
Differences between conventional breeding and genetic engineering: An assessment of the statement made by the Group of Chief Scientific Advisors’ (SAM) (2019) (0)
Crispr2vec: Machine Learning Model Predicts Off-Target Cuts of CRISPR systems (2020) (0)
Crystal structure of NmeCas9 HNH domain bound to anti-CRISPR AcrIIC1 (2017) (0)
CasX-gRNA-DNA(45bp) state I (2019) (0)
Crystal structure of the Csy4-crRNA product complex (2012) (0)
Science Magazine (2006) (0)
Crystal structure of the Csy4-crRNA complex, orthorhombic form (2010) (0)
- RESEARCHARTICLE CrystalStructureofa Group I Ribozyme Domain: Principles of RNA Packing (2016) (0)
Crystal structure of LbaCas13a H328A (C2c2) bound to pre-crRNA (24-nt spacer) (2017) (0)
Correction (2013) (0)
CasX ternary complex with 30bp target DNA (2019) (0)
Broad-spectrum CRISPR-Cas13a enables efficient phage genome editing (2022) (0)
Biology 1A - Lecture 12: Photosynthesis: The Light Reactions (2010) (0)
U1A SPLICEOSOMAL PROTEIN/HEPATITIS DELTA VIRUS GENOMIC RIBOZYME COMPLEX (1999) (0)
A compound that directly and selectively stalls PCSK9 translation (2016) (0)
Cas1-Cas2 bound to full-site mimic with Ni (2017) (0)
Guide bound structures of a divergent RNA-targeting A cleaving CRISPR-Cas13a enzyme (2017) (0)
Nuclease-inactive Streptococcus pyogenes Cas9 (D10A/H840A, dCas9) in complex with single-guide RNA at 3.1 Angstrom resolution (2015) (0)
Cryo-EM structure of LbCas12a-crRNA: AcrVA4 (1:2 complex) (2019) (0)
Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain (2018) (0)
Activating silent Argonautes (2013) (0)
Crystal structure of anemone STING (Nematostella vectensis) 'humanized' F276K in complex with 3', 3' c-di-GMP, c[G(3', 5')pG(3', 5')p]' (2015) (0)
Abstract 2302: The pan-cancer regulator of the mutant TERT promoter and a new model of the GABP-TERT axis (2022) (0)
Abstracts from HSG 2017 (2017) (0)
Target Recognition and Degradation by an Adaptive Bacterial Immune System (2014) (0)
Crystal structure of the Csy4-crRNA complex, monoclinic form (2010) (0)
Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase in complex with nonhydrolyzable GTP (2014) (0)
A TO OL FOR GENOME EDITING (2020) (0)
Crystal Structure of a RNA Molecule Containing Domain 5 and 6 of the Yeast ai5g Group II Self-splicing Intron (2002) (0)
Research highlights (2005) (0)
Precise Transcript Targeting by CRISPR-Csm Complexes (2022) (0)
Structure of Thermus thermophilus CasA (Cse1) (2012) (0)
Partial Cas6-RT-Cas1--Cas2 complex (2021) (0)
Cas6-RT-Cas1--Cas2 complex (2021) (0)
Engineering Inhibitor Specificity in the Dead-Box Protein Family (2014) (0)
Dual Upstream Open Reading Frames Control Translation of a Herpesviral Polycistronic mRNA By (2013) (0)
Crystal structure of anemone STING (Nematostella vectensis) in complex with 3', 3' c-di-GMP, c[G(3', 5')pG(3', 5')p] (2015) (0)
S0033583518000070jrv 1..11 (2018) (0)
Author response: Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex (2016) (0)
Crystal structure of the fluoroacetyl-CoA-specific thioesterase FlK in an open conformation (2010) (0)
A higher degree of difficulty. (2007) (0)
Crystal structure of the fluoroacetyl-CoA-specific thioesterase FlK in complex with fluoroacetate (2010) (0)
Protein-nucleic acid interactions. (2003) (0)
1999 XIII International Biophysics Congress 19-24 September 1999 New Delhi Abstracts Suppl (2016) (0)
Author response: Nucleosome breathing and remodeling constrain CRISPR-Cas9 function (2016) (0)
Improved Genome Editing by an Engineered CRISPR-Cas12a (2022) (0)
Author response: RNA-guided assembly of Rev-RRE nuclear export complexes (2014) (0)
Bacterial Rna Polymerases: the Wholo Story This Review Comes from a Themed Issue on Protein±nucleic Acid Interactions Edited (0)
The New Genetic Engineering Toolbox (0)
X-ray crystal structure of Marinitoga piezophila Argonaute in complex with 5' OH guide RNA (2016) (0)
Crystal structure of the Type II-C Cas9 enzyme from Actinomyces naeslundii (2014) (0)
Crystal structure of the Csy4-crRNA complex, hexagonal form (2010) (0)
Structural basis for RNA-regulated gene expression (2005) (0)
Methods and compositions for modifying target DNA directed RNA and modulation of transcription directed RNA (2013) (0)
Getting the message: Mechanisms of protein synthesis initiation (2008) (0)
cryo-EM structure of the Cas9-sgRNA-AcrIIA4 anti-CRISPR complex (2017) (0)
Crystal Structure of the Wild Type Hepatitis Delta Virus Gemonic Ribozyme Precursor, in EDTA solution (2004) (0)
Targeting and Degradation of Viral DNA by the CRISPR-Cas System of Escherichia Coli (2014) (0)
Crystal structure of the Cas1-Cas2 complex from Escherichia coli (2014) (0)
GENE-43. TARGETING GABPb1L INHIBITS IN VIVO GROWTH OF TERT PROMOTER MUTANT GLIOBLASTOMA (2019) (0)
DNA Targeting by a Minim al CRISPR RNA-Guided Cascade Graphical Abstract Highlights (0)
Crystal structure of the Csy4-minimal crRNA complex (2012) (0)
Cryo-EM structure of LbCas12a-crRNA: AcrVA4 (2:2 complex) (2019) (0)
Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase, a prokaryotic cGAS homolog (2014) (0)
Title Controlling CRISPR-Cas 9 with ligand-activated and ligand-deactivated sgRNAs (2019) (0)
Crystal structure of the F36A mutant of the fluoroacetyl-CoA-specific thioesterase FlK in complex with fluoroacetate and CoA (2010) (0)
A Conserved Mechanism of RNA Substrate Recognition and Cleavage by Fungal Dicers (2014) (0)
Ancient Origin of cGAS-ST ING Reveals Mechanism of Universal 2 0 , 3 0 cGAMP Signaling Graphical Abstract Highlights (2015) (0)
Structure of eukaryotic translation initiation factor 3 subunit D (eIF3d) cap binding domain from Nasonia vitripennis, Crystal form 1 (2016) (0)
Crystal structure of the S148ACsy4-crRNA complex (2012) (0)
Crystal structure of the F36A mutant of the fluoroacetyl-CoA-specific thioesterase FlK (2010) (0)
Crystal structure of S. pyogenes Cas9 (2014) (0)
Cas1-Cas2 bound to half-site intermediate (2017) (0)
Lawrence Berkeley National Laboratory Recent Work Title Target preference of Type IIIA CRISPR-Cas complexes at the transcription bubble (2019) (0)
CBIO-19. GENOME SHREDDING ENABLES CRISPR-MEDIATED GLIOBLASTOMA ONCOLYSIS (2021) (0)
Crystal structure of LbaCas13a (C2c2) bound to mature crRNA (24-nt spacer) (2017) (0)
Preliminary X-ray diffraction studies of an RNA pseudoknot that inhibits HIV-1 reverse transcriptase. (1996) (0)
Structure of Giardia Dicer refined against twinned data (2007) (0)
Coleridge’s Political Thought: Property, Morality and the Limits of Traditional Discourse (1990) (0)
Crystal Structure of the HCV IRES pseudoknot domain (2011) (0)

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