Jennifer Doudna
#727
Most Influential Person Now
American biochemist, (1964 – ), Washington, DC, USA
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Jennifer Doudnabiology Degrees
Biology
#37
World Rank
#76
Historical Rank
#23
USA Rank
Biotechnology
#5
World Rank
#5
Historical Rank
#2
USA Rank
Molecular Biology
#23
World Rank
#23
Historical Rank
#14
USA Rank
Biochemistry
#33
World Rank
#44
Historical Rank
#22
USA Rank
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Biology
Jennifer Doudna's Degrees
- Bachelors Biochemistry Pomona College
Why Is Jennifer Doudna Influential?
(Suggest an Edit or Addition)Areas of Specialization: Biochemistry, Molecular Biology
Jennifer Doudna is a Li Ka Shing Chancellor Chair Professor for the Department of Chemistry and Department of Molecular and Cell Biology at the University of California, Berkeley. In addition, she has been a professor at the University of California, San Francisco and an investigator with the Howard Hughes Medical Institute and senior investigator at the Gladstone Institutes. She earned a B.A. in biochemistry from Pomona College and a Ph.D. in biological chemistry and molecular pharmacology from Harvard Medical School.
She is best known for her work with CRISPR. She, along with her colleague Emmanuelle Charpentier, were the first to suggest that genes could be edited or reprogrammed, now considered one of the most impactful discoveries ever made in the field of biology.
For her work in gene editing, she has received numerous prestigious awards, including the Breakthrough Prize in Life Sciences, the Gruber Prize in Genetics, the Kavli Prize in Nanoscience and in 2016, she was runner-up for the Time magazine Person of the Year, alongside her fellow CRISPR colleagues.
She is a member of the National Academy of Sciences, the American Academy of Arts and Sciences, the National Academy of Medicine and the National Academy of Inventors. Doudna has been awarded the LUI Che Woo Prize for Welfare Betterment and, in 2020, earned the Nobel Prize in Chemistry, alongside Emmanuelle Charpentier, “for the development of a method for genome editing.”
Featured in Top Influential Biologists Today and Top Women in STEM
According to Wikipedia, Jennifer Anne Doudna is an American biochemist who has done pioneering work in CRISPR gene editing, and made other fundamental contributions in biochemistry and genetics. Doudna was one of the first women to share a Nobel in the sciences. She received the 2020 Nobel Prize in Chemistry, with Emmanuelle Charpentier, "for the development of a method for genome editing." She is the Li Ka Shing Chancellor's Chair Professor in the department of chemistry and the department of molecular and cell biology at the University of California, Berkeley. She has been an investigator with the Howard Hughes Medical Institute since 1997.
Jennifer Doudna's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity (2012) (11694)
- The new frontier of genome engineering with CRISPR-Cas9 (2014) (4399)
- Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression (2013) (3736)
- CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes (2013) (2839)
- RNA-programmed genome editing in human cells (2013) (1897)
- CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity (2018) (1623)
- RNA-guided genetic silencing systems in bacteria and archaea (2012) (1608)
- DNA interrogation by the CRISPR RNA-guided endonuclease Cas9 (2014) (1472)
- High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity (2013) (1315)
- Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing (1996) (1199)
- CRISPR-Cas9 Structures and Mechanisms. (2017) (1037)
- Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation (2014) (955)
- Structural Basis for Double-Stranded RNA Processing by Dicer (2006) (952)
- Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery (2014) (933)
- Molecular mechanisms of RNA interference. (2013) (850)
- Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering (2016) (845)
- CRISPR-Cas guides the future of genetic engineering (2018) (803)
- Enhanced proofreading governs CRISPR-Cas9 targeting accuracy (2017) (780)
- A three-dimensional view of the molecular machinery of RNA interference (2009) (724)
- Crystal structure of a hepatitis delta virus ribozyme (1998) (720)
- Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection (2016) (674)
- The chemical repertoire of natural ribozymes (2002) (658)
- Applications of CRISPR technologies in research and beyond (2016) (650)
- Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease (2010) (614)
- A prudent path forward for genomic engineering and germline gene modification (2015) (565)
- Generation of knock-in primary human T cells using Cas9 ribonucleoproteins (2015) (556)
- Programmed DNA destruction by miniature CRISPR-Cas14 enzymes (2018) (554)
- Structural basis for CRISPR RNA-guided DNA recognition by Cascade (2011) (524)
- Programmable RNA recognition and cleavage by CRISPR/Cas9 (2014) (510)
- Hepatitis C Virus IRES RNA-Induced Changes in the Conformation of the 40S Ribosomal Subunit (2001) (492)
- Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair (2017) (486)
- Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage (2016) (446)
- Conformational control of DNA target cleavage by CRISPR–Cas9 (2015) (445)
- In vitro reconstitution of the human RISC-loading complex (2008) (440)
- RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions (2011) (434)
- Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. (2009) (431)
- Programmable RNA Tracking in Live Cells with CRISPR/Cas9 (2016) (419)
- A Cas9–guide RNA complex preorganized for target DNA recognition (2015) (416)
- New CRISPR-Cas systems from uncultivated microbes (2016) (409)
- THE PROMISE AND CHALLENGE OF THERAPEUTIC GENOME EDITING (2020) (400)
- Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy (2020) (396)
- Crystal structure of the ribonucleoprotein core of the signal recognition particle. (2000) (390)
- Cas1–Cas2 complex formation mediates spacer acquisition during CRISPR–Cas adaptive immunity (2014) (379)
- Expanding the Biologist's Toolkit with CRISPR-Cas9. (2015) (376)
- Mechanism of ribosome recruitment by hepatitis C IRES RNA. (2001) (372)
- Structures of the RNA-guided surveillance complex from a bacterial immune system (2011) (370)
- Multiplexed RNA structure characterization with selective 2′-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq) (2011) (366)
- Adaptive strategies of the influenza virus polymerase for replication in humans (2009) (364)
- Cornerstones of CRISPR–Cas in drug discovery and therapy (2016) (343)
- Insights into RNA structure and function from genome-wide studies (2014) (341)
- RNA Tertiary Structure Mediation by Adenosine Platforms (1996) (332)
- Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity (2020) (318)
- Structural determinants of RNA recognition and cleavage by Dicer (2007) (310)
- Dynamics of CRISPR-Cas9 genome interrogation in living cells (2015) (290)
- Structural Roles for Human Translation Factor eIF3 in Initiation of Protein Synthesis (2005) (289)
- Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity (2015) (283)
- Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity. (2013) (277)
- Ribozyme structures and mechanisms. (2000) (268)
- A magnesium ion core at the heart of a ribozyme domain (1997) (265)
- Disabling Cas9 by an anti-CRISPR DNA mimic (2017) (256)
- Clades of huge phages from across Earth’s ecosystems (2019) (255)
- RNA targeting by the type III-A CRISPR-Cas Csm complex of Thermus thermophilus. (2014) (253)
- Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3 (2008) (252)
- CRISPR-CasΦ from huge phages is a hypercompact genome editor (2020) (249)
- Ribonuclease revisited: structural insights into ribonuclease III family enzymes. (2007) (248)
- Rational design of a split-Cas9 enzyme complex (2015) (248)
- A conformational switch controls hepatitis delta virus ribozyme catalysis (2004) (248)
- Enhanced proofreading governs CRISPR-Cas9 targeting accuracy Please share how this access benefits you. Your story matters (2018) (247)
- Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated genome defense. (2009) (245)
- Structural and mechanistic insights into hepatitis C viral translation initiation (2007) (243)
- Structural insights into RNA Processing by the Human RISC-Loading Complex (2009) (243)
- A universal mode of helix packing in RNA (2001) (236)
- Mechanism of foreign DNA selection in a bacterial adaptive immune system. (2012) (235)
- Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes (2017) (233)
- Autoinhibition of human dicer by its internal helicase domain. (2008) (231)
- eIF3d is an mRNA cap-binding protein required for specialized translation initiation (2016) (215)
- Structure and activity of the RNA-targeting Type III-B CRISPR-Cas complex of Thermus thermophilus. (2013) (213)
- Metal-binding sites in the major groove of a large ribozyme domain. (1996) (206)
- Cap-Independent Translation Is Required for Starvation-Induced Differentiation in Yeast (2007) (206)
- The hepatitis C virus internal ribosome entry site adopts an ion-dependent tertiary fold. (1999) (202)
- Tunable protein synthesis by transcript isoforms in human cells (2015) (200)
- RNA-catalysed synthesis of complementary-strand RNA (1989) (199)
- CRISPR-Cpf1 mediates efficient homology-directed repair and temperature-controlled genome editing (2017) (197)
- Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesis. (2015) (196)
- RNA processing enables predictable programming of gene expression (2012) (195)
- Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9 (2016) (194)
- Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA. (2004) (192)
- Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing (2013) (192)
- CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference (2014) (189)
- RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes. (2017) (188)
- A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9 (2017) (188)
- Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling. (2015) (187)
- A specific monovalent metal ion integral to the AA platform of the RNA tetraloop receptor (1998) (185)
- An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3 (2011) (183)
- Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation (2002) (180)
- CasX enzymes comprise a distinct family of RNA-guided genome editors (2019) (179)
- Precise and Heritable Genome Editing in Evolutionarily Diverse Nematodes Using TALENs and CRISPR/Cas9 to Engineer Insertions and Deletions (2013) (178)
- A Broad-Spectrum Inhibitor of CRISPR-Cas9 (2017) (174)
- Use of cis- and trans-ribozymes to remove 5' and 3' heterogeneities from milligrams of in vitro transcribed RNA. (1996) (174)
- Nucleosome breathing and remodeling constrain CRISPR-Cas9 function (2016) (173)
- An inhibitory activity in human cells restricts the function of an avian-like influenza virus polymerase. (2008) (167)
- Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System (2015) (163)
- Biotechnology: Rewriting a genome (2013) (161)
- Direct Link between RACK1 Function and Localization at the Ribosome In Vivo (2008) (160)
- ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing (2016) (159)
- Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch (2016) (159)
- Foreign DNA capture during CRISPR–Cas adaptive immunity (2015) (158)
- Crystallization of RNA and RNA-protein complexes. (2004) (156)
- RNA-based recognition and targeting: sowing the seeds of specificity (2017) (154)
- Coupled 5' nucleotide recognition and processivity in Xrn1-mediated mRNA decay. (2011) (152)
- Systematic discovery of natural CRISPR-Cas12a inhibitors (2018) (152)
- High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding (2017) (149)
- Mechanism of substrate selection by a highly specific CRISPR endoribonuclease. (2012) (148)
- The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor (2011) (144)
- Ribozyme catalysis: not different, just worse (2005) (144)
- Crystallization and structure determination of a hepatitis delta virus ribozyme: use of the RNA-binding protein U1A as a crystallization module. (2000) (142)
- siRNA repositioning for guide strand selection by human Dicer complexes. (2011) (141)
- Substrate-specific kinetics of Dicer-catalyzed RNA processing. (2010) (140)
- dsRNA with 5′ overhangs contributes to endogenous and antiviral RNA silencing pathways in plants (2009) (139)
- Rapid assessment of SARS-CoV-2–evolved variants using virus-like particles (2021) (138)
- Structural insights into the signal recognition particle. (2003) (137)
- Structure and Function of the Eukaryotic Ribosome The Next Frontier (2002) (136)
- TRBP alters human precursor microRNA processing in vitro. (2012) (134)
- Structural Characterization of the Human Eukaryotic Initiation Factor 3 Protein Complex by Mass Spectrometry*S (2007) (134)
- A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells. (2016) (133)
- Structural genomics of RNA (2000) (130)
- The structural biology of CRISPR-Cas systems. (2015) (130)
- RNA-dependent RNA targeting by CRISPR-Cas9 (2018) (128)
- CRISPR Immunological Memory Requires a Host Factor for Specificity. (2016) (128)
- Large-scale purification of a stable form of recombinant tobacco etch virus protease. (2001) (127)
- Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning (2015) (125)
- Specificity for aminoacylation of an RNA helix: an unpaired, exocyclic amino group in the minor groove. (1991) (124)
- A thermostable Cas9 with increased lifetime in human plasma (2017) (124)
- CRISPR germline engineering—the community speaks (2015) (124)
- Reconsidering movement of eukaryotic mRNAs between polysomes and P bodies. (2011) (122)
- Reassortment and Mutation of the Avian Influenza Virus Polymerase PA Subunit Overcome Species Barriers (2011) (121)
- Modeling and automation of sequencing-based characterization of RNA structure (2011) (119)
- The j-Subunit of Human Translation Initiation Factor eIF3 Is Required for the Stable Binding of eIF3 and Its Subcomplexes to 40 S Ribosomal Subunits in Vitro* (2004) (119)
- eIF3j is located in the decoding center of the human 40S ribosomal subunit. (2007) (118)
- Cutting it close: CRISPR-associated endoribonuclease structure and function. (2015) (117)
- Multiple sensors ensure guide strand selection in human RNAi pathways. (2013) (116)
- Crystal structure of the HCV IRES central domain reveals strategy for start-codon positioning. (2011) (115)
- A general module for RNA crystallization. (1998) (112)
- Hepatitis C Virus Internal Ribosome Entry Site (IRES) Stem Loop IIId Contains a Phylogenetically Conserved GGG Triplet Essential for Translation and IRES Folding (2000) (111)
- Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3) (2011) (109)
- Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation (2010) (109)
- Structures of the CRISPR genome integration complex (2017) (106)
- CRISPR-CasX is an RNA-dominated enzyme active for human genome editing (2019) (104)
- Mass spectrometric analysis of the human 40S ribosomal subunit: Native and HCV IRES‐bound complexes (2005) (104)
- Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity (2014) (103)
- Structure of Dicer and mechanistic implications for RNAi. (2006) (103)
- Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs (2018) (103)
- The new frontier of genome engineering with CRISPR-Cas 9 GENOME (2014) (103)
- Receptor‐Mediated Delivery of CRISPR‐Cas9 Endonuclease for Cell Type Specific Gene Editing (2018) (102)
- Specificity of RNA–RNA helix recognition (2002) (102)
- A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis. (1991) (100)
- Metal ions in ribozyme folding and catalysis. (2000) (99)
- Widespread Translational Remodeling during Human Neuronal Differentiation. (2017) (98)
- Structural and energetic analysis of RNA recognition by a universally conserved protein from the signal recognition particle. (2001) (97)
- Mutations in CIC and FUBP1 Contribute to Human Oligodendroglioma (2011) (96)
- Substrate-specific structural rearrangements of human Dicer (2013) (95)
- RNA folds: insights from recent crystal structures. (1999) (95)
- A bacterial Argonaute with noncanonical guide RNA specificity (2016) (95)
- 5 Translation Initiation by Viral Internal Ribosome Entry Sites (2007) (95)
- Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA (2012) (94)
- Structural Insights into Group II Intron Catalysis and Branch-Site Selection (2002) (91)
- Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants (2022) (91)
- Self-assembly of a group I intron active site from its component tertiary structural domains. (1995) (90)
- A nested double pseudoknot is required for self-cleavage activity of both the genomic and antigenomic hepatitis delta virus ribozymes. (1999) (90)
- The chemistry of Cas9 and its CRISPR colleagues (2017) (89)
- Direct pK(a) measurement of the active-site cytosine in a genomic hepatitis delta virus ribozyme. (2001) (89)
- Unconventional miR-122 binding stabilizes the HCV genome by forming a trimolecular RNA structure (2013) (88)
- RNA structure, not sequence, determines the 5' splice-site specificity of a group I intron. (1989) (88)
- Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules (2019) (86)
- Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes. (2015) (86)
- Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner. (2018) (85)
- Native Tandem and Ion Mobility Mass Spectrometry Highlight Structural and Modular Similarities in Clustered-Regularly-Interspaced Shot-Palindromic-Repeats (CRISPR)-associated Protein Complexes From Escherichia coli and Pseudomonas aeruginosa* (2012) (85)
- Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain (2017) (85)
- Guide-bound structures of an RNA-targeting A-cleaving CRISPR–Cas13a enzyme (2017) (85)
- Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination (2022) (84)
- Broad-spectrum enzymatic inhibition of CRISPR-Cas12a (2019) (82)
- Crystallization of ribozymes and small RNA motifs by a sparse matrix approach. (1993) (82)
- Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering. (2016) (82)
- Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases (2013) (82)
- Stereochemical course of catalysis by the Tetrahymena ribozyme. (1989) (81)
- Structural insights into RNA interference. (2010) (80)
- The HCV IRES pseudoknot positions the initiation codon on the 40S ribosomal subunit. (2010) (80)
- Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor. (1995) (79)
- RNA-guided assembly of Rev-RRE nuclear export complexes (2014) (79)
- RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a. (2018) (78)
- Coordinated activities of human dicer domains in regulatory RNA processing. (2012) (77)
- An essential GTPase promotes assembly of preribosomal RNA processing complexes. (2005) (76)
- CRISPR–Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV–host factor interactions (2018) (76)
- Ribozyme structures and mechanisms. (2001) (75)
- A Unified Resource for Tracking Anti-CRISPR Names. (2018) (74)
- The stem-loop binding protein forms a highly stable and specific complex with the 3' stem-loop of histone mRNAs. (2001) (73)
- RNA–protein analysis using a conditional CRISPR nuclease (2013) (72)
- Applications of CRISPR-Cas Enzymes in Cancer Therapeutics and Detection. (2018) (71)
- DNA capture by a CRISPR-Cas9–guided adenine base editor (2020) (70)
- RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System (2017) (70)
- SRP RNA provides the physiologically essential GTPase activation function in cotranslational protein targeting. (2006) (69)
- Genome-resolved metagenomics reveals site-specific diversity of episymbiotic CPR bacteria and DPANN archaea in groundwater ecosystems (2021) (69)
- Assembly of an active group II intron-maturase complex by protein dimerization. (2004) (68)
- Deciphering Off-Target Effects in CRISPR-Cas9 through Accelerated Molecular Dynamics (2019) (66)
- Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation (2013) (65)
- Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles (2021) (65)
- Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery (2017) (64)
- Hepatitis C virus 3′UTR regulates viral translation through direct interactions with the host translation machinery (2013) (64)
- DNA Targeting by a Minimal CRISPR RNA-Guided Cascade. (2016) (63)
- Species- and site-specific genome editing in complex bacterial communities (2021) (63)
- Controlling and enhancing CRISPR systems (2020) (62)
- Protecting genome integrity during CRISPR immune adaptation (2016) (60)
- The P5abc peripheral element facilitates preorganization of the tetrahymena group I ribozyme for catalysis. (2000) (60)
- Accelerated RNA detection using tandem CRISPR nucleases (2021) (60)
- Genomes in Focus: Development and Applications of CRISPR-Cas9 Imaging Technologies. (2018) (59)
- Mutational analysis of conserved nucleotides in a self-splicing group I intron. (1990) (59)
- Assembly of an exceptionally stable RNA tertiary interface in a group I ribozyme. (1999) (57)
- Author response: Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery (2014) (57)
- Structural roles of monovalent cations in the HDV ribozyme. (2007) (57)
- Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress (2016) (56)
- Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3* (2015) (56)
- Functional Overlap between eIF4G Isoforms in Saccharomyces cerevisiae (2010) (56)
- Machine learning predicts new anti-CRISPR proteins (2019) (56)
- Temperature-responsive competitive inhibition of CRISPR-Cas9 (2018) (56)
- Key role of the REC lobe during CRISPR–Cas9 activation by ‘sensing’, ‘regulating’, and ‘locking’ the catalytic HNH domain (2018) (56)
- ATP-independent diffusion of double-stranded RNA binding proteins (2012) (54)
- CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification (2019) (54)
- The NIH Somatic Cell Genome Editing program (2021) (53)
- Massively parallel kinetic profiling of natural and engineered CRISPR nucleases (2019) (52)
- THE P4-P6 DOMAIN DIRECTS HIGHER ORDER FOLDING OF THE TETRAHYMENA RIBOZYME CORE (1997) (50)
- RNA-mediated interaction between the peptide-binding and GTPase domains of the signal recognition particle (2005) (47)
- Targeted delivery of CRISPR-Cas9 and transgenes enables complex immune cell engineering (2021) (46)
- Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling (2020) (43)
- Mutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune Response. (2017) (43)
- GTP-dependent formation of a ribonucleoprotein subcomplex required for ribosome biogenesis. (2006) (42)
- Structural and energetic analysis of metal ions essential to SRP signal recognition domain assembly. (2002) (41)
- Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2 (2019) (40)
- Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes (2019) (40)
- Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a (2019) (39)
- Ribozyme-catalyzed primer extension by trinucleotides: a model for the RNA-catalyzed replication of RNA. (1993) (39)
- RNA seeing double: close-packing of helices in RNA tertiary structure. (1997) (39)
- CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks (2020) (38)
- Limited cross-variant immunity after infection with the SARS-CoV-2 Omicron variant without vaccination (2022) (38)
- Engineering of Monosized Lipid-Coated Mesoporous Silica Nanoparticles for CRISPR Delivery. (2020) (38)
- Chemical synthesis of oligoribonucleotides containing 2-aminopurine: substrates for the investigation of ribozyme function. (1990) (37)
- Accelerated RNA detection using tandem CRISPR nucleases (2021) (36)
- Genome-editing revolution: My whirlwind year with CRISPR (2015) (35)
- Miniribozymes, small derivatives of the sunY intron, are catalytically active (1989) (35)
- Template-directed primer extension catalyzed by the Tetrahymena ribozyme. (1991) (35)
- Site-Specific Bioconjugation through Enzyme-Catalyzed Tyrosine–Cysteine Bond Formation (2020) (34)
- Blueprint for a pop-up SARS-CoV-2 testing lab (2020) (34)
- A scoutRNA Is Required for Some Type V CRISPR-Cas Systems. (2020) (34)
- Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex (2016) (33)
- Kinetic analysis of Cas12a and Cas13a RNA-Guided nucleases for development of improved CRISPR-Based diagnostics (2021) (33)
- Distinct contributions of KH domains to substrate binding affinity of Drosophila P-element somatic inhibitor protein. (2005) (33)
- DNA recognition by an RNA-guided bacterial Argonaute (2017) (32)
- Preparation of homogeneous ribozyme RNA for crystallization. (1997) (32)
- The P4-P6 domain directs higher order folding of the Tetrahymena ribozyme core. (1997) (31)
- A Host of Factors Regulating Influenza Virus Replication (2010) (31)
- Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies (2016) (31)
- Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity. (2010) (30)
- Structural biology of CRISPR–Cas immunity and genome editing enzymes (2022) (30)
- New tools provide a second look at HDV ribozyme structure, dynamics and cleavage (2014) (30)
- RNA structure: crystal clear? (1997) (30)
- Candidate Phyla Radiation Roizmanbacteria From Hot Springs Have Novel and Unexpectedly Abundant CRISPR-Cas Systems (2019) (29)
- Targeted Genome Editing of Bacteria Within Microbial Communities (2020) (29)
- Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble (2019) (29)
- Programmable RNA recognition using a CRISPR-associated Argonaute (2017) (29)
- Identification and analysis of U5 snRNA variants in Drosophila. (2005) (28)
- Emerging themes in RNA folding. (1997) (28)
- Genomic engineering and the future of medicine. (2015) (27)
- Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas 9 (2016) (27)
- Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation (2020) (26)
- The parallel universe of RNA folding (1998) (26)
- Perspective: Embryo editing needs scrutiny (2015) (25)
- Solving large RNA structures by X-ray crystallography. (2000) (24)
- CRISPR-Cas9 bends and twists DNA to read its sequence (2021) (24)
- Methods in Enzymology. The use of CRISPR/Cas9, ZFNs, and TALENs in generating site-specific genome alterations. Preface. (2014) (23)
- Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles (2022) (23)
- The pathway of HCV mRNA recruitment to the human ribosome (2009) (23)
- A fast and efficient procedure to produce scFvs specific for large macromolecular complexes. (2007) (22)
- Hepatitis C Virus IRES RNA—Induced Changes in the Conformation of the 40S (2001) (22)
- DNA interference states of the hypercompact CRISPR–CasΦ effector (2021) (21)
- CRISPR technology: A decade of genome editing is only the beginning (2023) (21)
- Direct detection of SARS-CoV-2 using CRISPR-Cas13a and a mobile phone (2020) (21)
- A Functional Mini-Integrase in a Two-Protein-type V-C CRISPR System. (2019) (21)
- Molecular Biology: Principles and Practice (2011) (20)
- Comprehensive deletion landscape of CRISPR-Cas9 identifies minimal RNA-guided DNA-binding modules (2020) (19)
- Launching a saliva-based SARS-CoV-2 surveillance testing program on a university campus (2021) (19)
- Genome editing: the end of the beginning (2015) (19)
- Methods to Crystallize RNA (2000) (19)
- Human Molecular Genetics and Genomics - Important Advances and Exciting Possibilities. (2021) (18)
- Enhancement of hepatitis C viral RNA abundance by precursor miR-122 molecules (2013) (18)
- Spacer Acquisition Rates Determine the Immunological Diversity of the Type II CRISPR-Cas Immune Response. (2019) (18)
- Rapid detection of SARS-CoV-2 RNA in saliva via Cas13 (2022) (17)
- Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage (2020) (17)
- Genetic dissection of an RNA enzyme. (1987) (17)
- CRISPR-Cas12a target binding unleashes single-stranded DNase activity (2017) (16)
- Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression (2021) (15)
- Quantification of Cas9 binding and cleavage across diverse guide sequences maps landscapes of target engagement (2020) (15)
- An unusual case of pseudo-merohedral twinning in orthorhombic crystals of Dicer. (2007) (14)
- Mechanisms of internal ribosome entry in translation initiation. (2001) (14)
- A functional map of HIV-host interactions in primary human T cells (2022) (14)
- A Nobel Prize for genetic scissors (2020) (14)
- Optimizing COVID-19 control with asymptomatic surveillance testing in a university environment (2020) (14)
- Evolutionarily Conserved Roles of the Dicer Helicase Domain in Regulating RNA Interference Processing* (2014) (14)
- Quantitative studies of ribosome conformational dynamics (2007) (14)
- Hammerhead ribozyme structure: U-turn for RNA structural biology. (1995) (13)
- Distinct sites of phosphorothioate substitution interfere with folding and splicing of the Anabaena group I intron. (2004) (13)
- Chemical biology at the crossroads of molecular structure and mechanism (2005) (12)
- Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity. (2022) (12)
- RNA-binding and HEPN nuclease activation are decoupled in CRISPR-Cas13a (2017) (12)
- The use of CRISPR/Cas9, ZFNs, TALENs in generating site specific genome alterations (2014) (12)
- Reactions to the National Academies/Royal Society Report on Heritable Human Genome Editing. (2020) (11)
- Guided Tour to the Heart of RISC (2012) (11)
- Conserved but nonessential interaction of SRP RNA with translation factor EF-G. (2004) (11)
- Analog sensitive chemical inhibition of the DEAD‐box protein DDX3 (2016) (11)
- Widespread translational remodeling during human neuronal differentiation (2017) (10)
- Advances in Genome Editing (2016) (10)
- Engineering improved Cas13 effectors for targeted post-transcriptional regulation of gene expression (2021) (10)
- Broad-spectrum CRISPR-Cas13a enables efficient phage genome editing (2022) (10)
- Rapid detection of SARS-CoV-2 with Cas13 (2020) (10)
- Robotic RNA extraction for SARS-CoV-2 surveillance using saliva samples (2021) (9)
- A naturally DNase-free CRISPR-Cas12c enzyme silences gene expression (2021) (9)
- 1 1 2 Enhanced proofreading governs CRISPR-Cas 9 targeting accuracy 3 4 (2017) (9)
- Optimized High-Throughput Screen for Hepatitis C Virus Translation Inhibitors (2011) (9)
- Optimizing COVID-19 control with asymptomatic surveillance testing in a university environment (2021) (9)
- RNA Scanning of a Molecular Machine with a Built-in Ruler. (2017) (9)
- CRISPR's unwanted anniversary (2019) (9)
- Rapid, point-of-care molecular diagnostics with Cas13 (2020) (9)
- Knocking out barriers to engineered cell activity (2020) (9)
- Establishing Suitability of RNA Preparations for Crystallization (1997) (9)
- Key role of the REC lobe during CRISPR-Cas9 activation by 'sensing', 'regulating', and 'locking' the catalytic HNH domain. (2018) (9)
- Borgs are giant extrachromosomal elements with the potential to augment methane oxidation (2021) (9)
- Ribozymes: The hammerhead swings into action (1998) (9)
- Structural coordination between active sites of a CRISPR reverse transcriptase-integrase complex (2021) (8)
- Synthesis of Multi-Protein Complexes through Charge-Directed Sequential Activation of Tyrosine Residues. (2021) (8)
- High-throughput biochemical profiling reveals Cas9 off-target binding and unbinding heterogeneity (2016) (7)
- A CRISPR-Cas9–integrase complex generates precise DNA fragments for genome integration (2021) (7)
- A phosphoramidate substrate analog is a competitive inhibitor of the Tetrahymena group I ribozyme. (2000) (7)
- CRISPR-Cas : a laboratory manual (2016) (7)
- Ro’s Role in RNA Reconnaissance (2005) (7)
- Sensitive and multiplexed RNA detection with Cas13 droplets and kinetic barcoding (2021) (7)
- Molecular mechanism of off-target effects in CRISPR-Cas9 (2018) (7)
- Author response: RNA-programmed genome editing in human cells (2013) (7)
- Borgs are giant genetic elements with potential to expand metabolic capacity (2022) (7)
- Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity (2020) (7)
- CRISPR–Cas9-mediated nuclear transport and genomic integration of nanostructured genes in human primary cells (2022) (7)
- Diverse ATPase Proteins in Mobilomes Constitute a Large Potential Sink for Prokaryotic Host ATP (2021) (6)
- Huge and variable diversity of episymbiotic CPR bacteria and DPANN archaea in groundwater ecosystems (2020) (6)
- How Will Kinetics and Thermodynamics Inform Our Future Efforts to Understand and Build Biological Systems? (2017) (6)
- Creative catalysis: pieces of the RNA world jigsaw. (2001) (6)
- CRISPR-Cas9 mediated nuclear transport and genomic integration of nanostructured genes in human primary cells (2021) (6)
- Diverse virus-encoded CRISPR-Cas systems include streamlined genome editors (2022) (6)
- Get in LINE: Competition for Newly Minted Retrotransposon Proteins at the Ribosome. (2015) (5)
- CRISPR-RNAa: targeted activation of translation using dCas13 fusions to translation initiation factors (2022) (5)
- Author Correction: Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity (2020) (5)
- Robotic RNA extraction for SARS-CoV-2 surveillance using saliva samples (2021) (5)
- Massively parallel kinetic profiling of natural and engineered CRISPR nucleases (2020) (5)
- Reply to Nathamgari et al.: Nanopore electroporation for intracellular delivery of biological macromolecules (2019) (5)
- HEPATITIS DELTA VIRUS RIBOZYME (1999) (4)
- Treatment of Genetic Diseases With CRISPR Genome Editing. (2022) (4)
- 5 Catalytic Strategies of Self-Cleaving Ribozymes: Relics of an RNA World? (2006) (4)
- Voices of biotech (2016) (4)
- Resource Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression (2013) (4)
- Inhibition of CRISPR-Cas 9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC 2 (2019) (4)
- Decorating chromatin for enhanced genome editing using CRISPR-Cas9 (2022) (4)
- A sparse matrix approach to crystallizing ribozymes and RNA motifs. (1997) (4)
- Establishing suitability of RNA preparations for crystallization. Determination of polydispersity. (1997) (4)
- Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases (2021) (3)
- Nucleic acids and their protein partners. (2008) (3)
- LuNER: Multiplexed SARS-CoV-2 detection in clinical swab and wastewater samples (2021) (3)
- Precise Transcript Targeting by CRISPR-Csm Complexes (2022) (3)
- IGI-LuNER: single-well multiplexed RT-qPCR test for SARS-CoV-2 (2020) (3)
- RNA structure: A molecular contortionist (1997) (3)
- Resource Programmable RNA Tracking in Live Cells with CRISPR / Cas 9 Graphical (2016) (3)
- Activating silent Argonautes (2013) (3)
- Conserved features of TERT promoter duplications reveal an activation mechanism that mimics hotspot mutations in cancer (2022) (3)
- Methods and compositions for RNA-directed target DNA modification and for RNA-directed transcription modulation (2013) (3)
- Ribosomes: Cashing in on crystals (1999) (2)
- Rewriting the Code of Life: CRISPR Technology and Its Impact on the Future of Humanity (2017) (2)
- A CRISPR-Cas9 Genome Engineering Platform in Primary CD4+ T Cells for the Interrogation of HIV Host Factors (2017) (2)
- Hammering out the shape of a ribozyme. (1994) (2)
- Chemical Synthesis of Oligoribonucleotides Containing 2‐Aminopurine: Substrates for the Investigation of Ribozyme Function. (1991) (2)
- Identifying RNA contacts from SHAPE-MaP by partial correlation analysis (2014) (2)
- Improved genome editing by an engineered CRISPR-Cas12a (2022) (2)
- The promise and challenge of therapeutic genome editing (2020) (2)
- Protein–nucleic Acid Interactions Editorial Overview (2)
- Comprar Molecular Biology. Principles And Practice (International Student Edition) | Michael O'Donnell | 9781464102257 | W.H. Freeman (2011) (2)
- Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs (2019) (2)
- Author Correction: CasX enzymes comprise a distinct family of RNA-guided genome editors (2019) (2)
- RNAs regulate biology. (2006) (2)
- Candidate Phyla Radiation Roizmanbacteria from hot springs have novel, unexpectedly abundant, and potentially alternatively functioning CRISPR-Cas systems (2018) (2)
- Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells (2023) (2)
- RNA-targeting CRISPR-Cas13 Provides Broad-spectrum Phage Immunity (2022) (2)
- RNA: primed for packing? (2004) (1)
- Spotlight: A Conversation with Laura Kiessling and Jennifer Doudna. (2018) (1)
- Crystal structure of an RNA/DNA strand exchange junction (2022) (1)
- CRISPR–Cas9 bends and twists DNA to read its sequence (2022) (1)
- Crispr2vec: Machine Learning Model Predicts Off-Target Cuts of CRISPR systems (2020) (1)
- Protein-nucleic acid interactions: unlocking mysteries old and new. (2005) (1)
- Global landscape of the host response to SARS-CoV-2 variants reveals viral evolutionary trajectories (2022) (1)
- STRUCTURE OF THE RIBONUCLEOPROTEIN CORE OF THE E. COLI SIGNAL RECOGNITION PARTICLE (2000) (1)
- A Second Look at the HDV Ribozyme Structure and Dynamics. (2014) (1)
- RNA-catalysed synthesis of complementary strand RNA (1989) (1)
- Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA.1 variant through NSP6 (2023) (1)
- Conformational Dynamics of Cas9 during DNA Binding (2017) (1)
- Correction: RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System (2017) (1)
- Meeting Report: The Allied Genetics Conference 2016 (2016) (1)
- Native and HCV IRES-bound complexes Mass spectrometric analysis of the human 40 S ribosomal subunit : (2005) (1)
- Foreign DNA capture during CRISPR–Cas adaptive immunity (2015) (1)
- Structural Characterization and Identification of Post‐Translational Modifications of Human Eukaryotic Initiation Factor 3 (eIF3) by FTICR Mass Spectrometry (2006) (1)
- The Dicer-TRBP Interface Structure and Implications for Strand Selection During Microrna Biogenesis (2014) (1)
- Lawrence Berkeley National Laboratory Recent Work Title RNA-dependent RNA targeting by CRISPR-Cas 9 Permalink (2018) (1)
- Protein-Nucleic Acid Interactions III (2014) (1)
- Genome editing in plants using the compact editor CasΦ (2022) (1)
- Supplemental Information RNA Targeting by the Type IIIA CRISPR-Cas Csm Complex of Thermus thermophilus (2014) (1)
- Real-Time Observation of DNA Recognition by the RNA-Guided Endonuclease Cas9 using Single-Molecule FRET (2015) (1)
- To TnpB or not TnpB? Cas12 is the answer (2023) (1)
- Site-Specific Generation of Protein-Protein Conjugates Using Native Amino Acids (2019) (1)
- Author response: Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies (2016) (1)
- Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair (2017) (1)
- Structural coordination between active sites of a Cas6-reverse transcriptase-Cas1—Cas2 CRISPR integrase complex (2020) (1)
- Corrigendum to "Engineering of monosized lipid-coated mesoporous silica nanoparticles for CRISPR delivery" Acta Biomaterialia (2020), 114, 358-368. (2020) (1)
- Programmable enveloped delivery vehicles for human genome engineering in vivo (2023) (1)
- Crystal structure the Escherichia coli Cas1-Cas2 complex bound to protospacer DNA and Mg (2015) (1)
- Structure of Giardia Dicer refined against twinned data (2007) (0)
- Crystal structure of Xrn1-substrate complex (2011) (0)
- CasX ternary complex with 30bp target DNA (2019) (0)
- CasX-gRNA-DNA(30bp) State II (2019) (0)
- Casz compositions and methods of use (2018) (0)
- Structure of the SpCas9 DNA adenine base editor - ABE8e (2020) (0)
- X-ray crystal structure of Marinitoga piezophila Argonaute in complex with 5' OH guide RNA (2016) (0)
- A higher degree of difficulty. (2007) (0)
- Crystal structure of the F36A mutant of the fluoroacetyl-CoA-specific thioesterase FlK in complex with fluoroacetate and CoA (2010) (0)
- 6.04 – RNA Structures Determined by X-ray Crystallography (1999) (0)
- DNA Targeting by a Minim al CRISPR RNA-Guided Cascade Graphical Abstract Highlights (0)
- The New Genetic Engineering Toolbox (0)
- Crystal Structure of Dicer from Giardia intestinalis (2006) (0)
- Structural Basis for Foreign DNA Integration in CRISPR Adaptive Immunity (2014) (0)
- Trbp Sliding Promotes Dicer's Cleavage Activity (2012) (0)
- CryoEM structure of AcrIIA2 in complex with CRISPR-Cas9 (2019) (0)
- Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase in complex with nonhydrolyzable GTP (2014) (0)
- CBIO-19. GENOME SHREDDING ENABLES CRISPR-MEDIATED GLIOBLASTOMA ONCOLYSIS (2021) (0)
- Jennifer Doudna and Emmanuelle Charpentier’s Experiment About the CRISPR/cas 9 System’s Role in Adaptive Bacterial Immunity (2012) (2017) (0)
- cryo-EM structure of the Cas9-sgRNA-AcrIIA4 anti-CRISPR complex (2017) (0)
- Guide bound structures of a divergent RNA-targeting A cleaving CRISPR-Cas13a enzyme (2017) (0)
- Structure of eukaryotic translation initiation factor 3 subunit D (eIF3d) cap binding domain from Nasonia vitripennis, Crystal form 3 (2016) (0)
- Cryo-EM structure of CasPhi-2 (Cas12j) bound to crRNA and DNA (2021) (0)
- A compound that directly and selectively stalls PCSK9 translation (2016) (0)
- Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble (2019) (0)
- Author Correction: Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity (2020) (0)
- The Right Chemistry: an Updated Nucleic Acids Textbook (2007) (0)
- Defending the Genome: Regulatory RNA in Humans and Bacteria (2013) (0)
- Crystal Structure of the HCV IRES pseudoknot domain (2011) (0)
- Crystal structure of catalytically-active Streptococcus pyogenes CRISPR-Cas9 in complex with single-guided RNA and double-stranded DNA primed for target DNA cleavage (2016) (0)
- Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Precursor, with C75U mutaion, in Cobalt Hexammine solution (2004) (0)
- Coleridge’s Political Thought: Property, Morality and the Limits of Traditional Discourse (1990) (0)
- Crystal structure of Mn-bound S.pyogenes Cas9 (2014) (0)
- A thermostable Cas9 with increased lifetime in human plasma (2017) (0)
- Biology 1A - Lecture 9: Introduction to Bioenergetics (2010) (0)
- Crystal structure of the F36A mutant of the fluoroacetyl-CoA-specific thioesterase FlK (2010) (0)
- Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA.1 variant through NSP6 (2023) (0)
- Preliminary in vitro functional analysis of the DEAD‐box protein DDX3 (2012) (0)
- Crystal structure of the Csy4-crRNA product complex (2012) (0)
- Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Precursor, with C75U mutaion, in EDTA solution (2004) (0)
- CRISPR-Cpf1 mediates efficient homology-directed repair and temperature-controlled genome editing (2017) (0)
- CRISPR–Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV–host factor interactions (2018) (0)
- Crystal structure of anemone STING (Nematostella vectensis) in complex with 3',3' c-di-AMP, c[A(3',5')pA(3',5')p] (2015) (0)
- Template-directed primer extension catalyzed by the Tetrahymena ribozyme (1991) (0)
- FREE with your next issue of TiBS: A Trends Guide to Proteomics (2001) (0)
- Engineering Inhibitor Specificity in the Dead-Box Protein Family (2014) (0)
- Cas1-Cas2 bound to full-site mimic with Ni (2017) (0)
- U1A SPLICEOSOMAL PROTEIN/HEPATITIS DELTA VIRUS GENOMIC RIBOZYME COMPLEX (1999) (0)
- Bacterial Rna Polymerases: the Wholo Story This Review Comes from a Themed Issue on Protein±nucleic Acid Interactions Edited (0)
- The NAI Fellow Profile: An Interview with Dr. Jennifer Doudna (2019) (0)
- Species- and site-specific genome editing in complex bacterial communities (2021) (0)
- Cas1-Cas2 bound to half-site intermediate (2017) (0)
- Structural Basis for RNA Processing by Dicer (2006) (0)
- Protein-nucleic acid interactions. (2003) (0)
- Getting the message: Mechanisms of protein synthesis initiation (2008) (0)
- Rna-guided nucleic acid modifying enzymes and methods of use thereof (2017) (0)
- Broad-spectrum enzymatic inhibition of CRISPR-Cas12a (2019) (0)
- Nuclease-inactive Streptococcus pyogenes Cas9 (D10A/H840A, dCas9) in complex with single-guide RNA at 3.1 Angstrom resolution (2015) (0)
- Biology 1A - Lecture 12: Photosynthesis: The Light Reactions (2010) (0)
- Activating silent Argonautes (2013) (0)
- GENE-43. TARGETING GABPb1L INHIBITS IN VIVO GROWTH OF TERT PROMOTER MUTANT GLIOBLASTOMA (2019) (0)
- Crystal structure of a C75U mutant Hepatitis Delta Virus ribozyme precursor, in Cu2+ solution (2004) (0)
- Targeting and Degradation of Viral DNA by the CRISPR-Cas System of Escherichia Coli (2014) (0)
- Differences between conventional breeding and genetic engineering: An assessment of the statement made by the Group of Chief Scientific Advisors’ (SAM) (2019) (0)
- CRISPR System: From Adaptive Immunity to Genome Editing (2017) (0)
- Author response: CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks (2020) (0)
- Single-Molecule Observation of Viral DNA Targeting by CRISPR/Cas Immune Systems (2013) (0)
- Crystal structure of the active catalytic core of the human DEAD-box protein DDX3 bound to AMPPNP (2015) (0)
- Crystal Structure of the Yeast Orthologue of RACK1, Asc1. (2009) (0)
- Genomic analysis of cultivated infant microbiomes identifies Bifidobacterium 2’-fucosyllactose utilization can be facilitated by co-existing species (2023) (0)
- Title Controlling CRISPR-Cas 9 with ligand-activated and ligand-deactivated sgRNAs (2019) (0)
- A Conserved Mechanism of RNA Substrate Recognition and Cleavage by Fungal Dicers (2014) (0)
- Crystal structure of the PABC-TNRC6C complex (2010) (0)
- Tertiary Motifs in RNA Structure and Folding (1999) (0)
- Author response: RNA-guided assembly of Rev-RRE nuclear export complexes (2014) (0)
- Cas6-RT-Cas1--Cas2 complex (2021) (0)
- CRISPR's Second Decade: Jennifer Doudna Looks Forward and Back (2022) (0)
- Lawrence Berkeley National Laboratory Recent Work Title Target preference of Type IIIA CRISPR-Cas complexes at the transcription bubble (2019) (0)
- Crystal Structure of the Wild Type Hepatitis Delta Virus Gemonic Ribozyme Precursor, in EDTA solution (2004) (0)
- Genome editing in the mouse brain with minimally immunogenic Cas9 RNPs (2023) (0)
- Life sciences, philanthropy, information science, space science (2001) (0)
- Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Precursor, with C75U mutaion, in Imidazole and Sr2+ solution (2004) (0)
- Crystal structure of LbaCas13a (C2c2) bound to mature crRNA (24-nt spacer) (2017) (0)
- 1999 XIII International Biophysics Congress 19-24 September 1999 New Delhi Abstracts Suppl (2016) (0)
- Crystal structure of the fluoroacetyl-CoA-specific thioesterase, FlK (2010) (0)
- Erratum: Molecular Mechanisms of RNA Interference (2020) (0)
- Forum: CRISPR roundtable with Doudna and Liu (2020) (0)
- Methods and compositions for modifying target DNA directed RNA and modulation of transcription directed RNA (2013) (0)
- Correction (2013) (0)
- CasX enzymes comprise a distinct family of RNA-guided genome editors (2019) (0)
- Abstracts from HSG 2017 (2017) (0)
- Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2 (2019) (0)
- X-ray crystal structure of human cyclic GMP-AMP synthase (cGAS) (2013) (0)
- Crystal structure of the Csy4-crRNA complex, orthorhombic form (2010) (0)
- Crystal structure of S. pyogenes Cas9 (2014) (0)
- RNAPrimed for Packing (2004) (0)
- Crystal structure of LbaCas13a H328A (C2c2) bound to pre-crRNA (24-nt spacer) (2017) (0)
- Crystal structure the Escherichia coli Cas1-Cas2 complex bound to protospacer DNA with splayed ends (2015) (0)
- Crystal Structure of a Mutant (C109G,G212C) P4-P6 Domain of the Group I Intron from Tetrahymena Thermophilia (2002) (0)
- Structural basis for RNA-regulated gene expression (2005) (0)
- Crystal structure of the Csy4-crRNA complex, monoclinic form (2010) (0)
- A Conversation with Jennifer Doudna. (2015) (0)
- Genome expansion by a CRISPR trimmer-integrase (2023) (0)
- Target Recognition and Degradation by an Adaptive Bacterial Immune System (2014) (0)
- Crystal structure of the S148ACsy4-crRNA complex (2012) (0)
- Cas1-Cas2 bound to full-site mimic (2017) (0)
- Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Product with C75U Mutaion, cleaved in Imidazole and Mg2+ solutions (2004) (0)
- Author response: Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex (2016) (0)
- Dual Upstream Open Reading Frames Control Translation of a Herpesviral Polycistronic mRNA By (2013) (0)
- Crystal structure of the Cas1-Cas2 complex from Escherichia coli (2014) (0)
- Structure A of CRISPR endoribonuclease Cse3 bound to 19 nt RNA (2011) (0)
- Crystal structure of the Type II-C Cas9 enzyme from Actinomyces naeslundii (2014) (0)
- CRISPR/CAS FACES THE BIOETHICS SPOTLIGHT (2015) (0)
- Plat Single Molecule Fluorescence Imaging at Micromolar Concentrations (2012) (0)
- CasX-gRNA-DNA(45bp) state I (2019) (0)
- Clades of huge phages from across Earth’s ecosystems (2020) (0)
- Crystal structure of catalytically-active Streptococcus pyogenes Cas9 in complex with single-guide RNA at 2.9 Angstrom resolution (2015) (0)
- Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase, a prokaryotic cGAS homolog (2014) (0)
- Crystal structure of the active catalytic core of the human DEAD-box protein DDX3 (2015) (0)
- Cas6 (TTHA0078) product complex (2013) (0)
- Crystal structure of anemone STING (Nematostella vectensis) in complex with 3', 3' c-di-GMP, c[G(3', 5')pG(3', 5')p] (2015) (0)
- Structure of eukaryotic translation initiation factor 3 subunit D (eIF3d) cap binding domain from Nasonia vitripennis, Crystal form 1 (2016) (0)
- Hepatitis Delta Virus gemonic ribozyme precursor with C75U mutation and bound to monovalent cation Tl (2007) (0)
- Cryo-EM structure of LbCas12a-crRNA: AcrVA4 (1:2 complex) (2019) (0)
- Crystal structure of anemone STING (Nematostella vectensis) 'humanized' F276K in complex with 3', 3' c-di-GMP, c[G(3', 5')pG(3', 5')p]' (2015) (0)
- Crystal structure of the fluoroacetyl-CoA-specific thioesterase FlK in complex with fluoroacetate (2010) (0)
- Perspective: Embryo editing needs scrutiny: Genome-editing presents many opportunities. But the advent of human-germline editing brings urgency to ethical discussions, says jennifer doudna. (2015) (0)
- 3 – RNA Structures Determined by X-ray Crystallography (2001) (0)
- Crystal structure of the active catalytic core of the human DEAD-box protein DDX3 bound to AMP (2015) (0)
- Partial Cas6-RT-Cas1--Cas2 complex (2021) (0)
- Cas6 (TTHB231) product complex (2013) (0)
- - RESEARCHARTICLE CrystalStructureofa Group I Ribozyme Domain: Principles of RNA Packing (2016) (0)
- Cas6 (TTHA0078) substrate mimic complex (2013) (0)
- Hepatitis Delta Virus Gemonic Ribozyme Precursor, with Mg2+ Bound (2004) (0)
- Crystal structure of the Dicer-TRBP interface (2014) (0)
- Author response: Nucleosome breathing and remodeling constrain CRISPR-Cas9 function (2016) (0)
- Preliminary X-ray diffraction studies of an RNA pseudoknot that inhibits HIV-1 reverse transcriptase. (1996) (0)
- Single-molecule analysis of DNA interrogation by Cas9 and Cas12a on supercoiled DNA (2022) (0)
- Crystal structure of anemone STING (Nematostella vectensis) in apo 'unrotated' closed conformation (2015) (0)
- Cryo-EM structure of CasPhi-2 (Cas12j) bound to crRNA and Phosphorothioate-DNA (2021) (0)
- CRISPR book review — Doudna responds (2017) (0)
- Cashing in on crystals. (1999) (0)
- A TO OL FOR GENOME EDITING (2020) (0)
- Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain (2018) (0)
- Crystal Structure of a RNA Molecule Containing Domain 5 and 6 of the Yeast ai5g Group II Self-splicing Intron (2002) (0)
- Crystal structure of the Csy4-crRNA complex, hexagonal form (2010) (0)
- Ancient Origin of cGAS-ST ING Reveals Mechanism of Universal 2 0 , 3 0 cGAMP Signaling Graphical Abstract Highlights (2015) (0)
- Crystal structure of the fluoroacetyl-CoA-specific thioesterase FlK in an open conformation (2010) (0)
- Structure of eukaryotic translation initiation factor 3 subunit D (eIF3d) cap binding domain from Nasonia vitripennis, Crystal form 2 (2016) (0)
- Author Correction: CasX enzymes comprise a distinct family of RNA-guided genome editors (2019) (0)
- Science Magazine (2006) (0)
- Abstract 2302: The pan-cancer regulator of the mutant TERT promoter and a new model of the GABP-TERT axis (2022) (0)
- Guided DNA Endonuclease in Adaptive - A Programmable Dual-RNA (2013) (0)
- Hepatitis Delta Virus ribozyme precursor structure, with C75U mutation, bound to Tl+ and cobalt hexammine (Co(NH3)63+) (2007) (0)
- S0033583518000070jrv 1..11 (2018) (0)
- Cryo-EM structure of LbCas12a-crRNA: AcrVA4 (2:2 complex) (2019) (0)
- Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase in complex with linear intermediate 5' pppA(3',5')pG (2014) (0)
- Crystal structure of the Csy4-minimal crRNA complex (2012) (0)
- X-ray crystal structure of Marinitoga piezophila Argonaute in complex with 5' OH guide RNA and target DNA (2017) (0)
- Research highlights (2005) (0)
- Structure of Thermus thermophilus CasA (Cse1) (2012) (0)
- Crystal structure of NmeCas9 HNH domain bound to anti-CRISPR AcrIIC1 (2017) (0)
- Recognition Particle Crystal Structure of the Ribonucleoprotein Core of the Signal (2013) (0)
- of human Dicer-binding proteins and PACT in small RNA processing. (2013) (0)
- Cryo-EM structure of CasPhi-2 (Cas12j) bound to crRNA (2021) (0)
- Genome editing: the end of the beginning (2015) (0)
- Attachment of a 32P-phosphate to the 3' Terminus of a DNA Oligonucleotide. (2020) (0)
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