Jens Claus Brüning
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German geneticist
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Biology
Jens Claus Brüning's Degrees
- PhD Genetics University of Cologne
- Masters Biology University of Cologne
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(Suggest an Edit or Addition)Jens Claus Brüning's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene (1994) (1285)
- A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. (1998) (1166)
- Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes (1999) (1162)
- Role of Brain Insulin Receptor in Control of Body Weight and Reproduction (2000) (952)
- Inactivation of the Fto gene protects from obesity (2009) (868)
- Role of brain insulin receptor in control of body weight and reproduction. (2006) (859)
- Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. (2011) (791)
- Agouti-related peptide–expressing neurons are mandatory for feeding (2005) (705)
- Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition (2010) (695)
- A guide to analysis of mouse energy metabolism (2011) (641)
- Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. (2007) (638)
- The role of insulin receptor signaling in the brain (2005) (578)
- Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles (1997) (559)
- Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism (2011) (477)
- Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance. (2014) (465)
- MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. (2009) (445)
- Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression (1999) (432)
- Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin (2014) (428)
- Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity (2017) (420)
- Central insulin action in energy and glucose homeostasis. (2006) (417)
- The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry (2013) (397)
- FOXO1 couples metabolic activity and growth state in the vascular endothelium (2015) (393)
- NK cells link obesity-induced adipose stress to inflammation and insulin resistance (2015) (372)
- Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. (2010) (359)
- Role for neuronal insulin resistance in neurodegenerative diseases (2004) (354)
- Toll-like receptors: linking inflammation to metabolism (2011) (319)
- A link between FTO, ghrelin, and impaired brain food-cue responsivity. (2013) (318)
- Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. (2006) (307)
- Versatile functions for IL-6 in metabolism and cancer. (2015) (302)
- Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b (2013) (292)
- Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. (1999) (288)
- Neonatal Insulin Action Impairs Hypothalamic Neurocircuit Formation in Response to Maternal High-Fat Feeding (2014) (283)
- Role for neuronal insulin resistance in neurodegenerative diseases. (2004) (269)
- CNS leptin and insulin action in the control of energy homeostasis (2010) (252)
- Selective insulin and leptin resistance in metabolic disorders. (2012) (251)
- Hypothalamic inflammation in obesity and metabolic disease (2017) (250)
- Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells (1997) (222)
- High-fat Feeding Promotes Obesity via Insulin Receptor/PI3k-Dependent Inhibition of SF-1 VMH Neurons (2011) (215)
- Central insulin action regulates peripheral glucose and fat metabolism in mice. (2008) (215)
- Hormone and glucose signalling in POMC and AgRP neurons (2009) (215)
- Erratum: Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene (Nature (1994) 372 (186-190)) (1994) (210)
- Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance. (2001) (208)
- Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action. (2010) (207)
- Neuronal IGF‐1 resistance reduces Aβ accumulation and protects against premature death in a model of Alzheimer's disease (2009) (207)
- Riboflavin kinase couples TNF receptor 1 to NADPH oxidase (2009) (202)
- Role of the fatty acid binding protein mal1 in obesity and insulin resistance. (2003) (199)
- Control of energy homeostasis by insulin and leptin: Targeting the arcuate nucleus and beyond (2009) (197)
- AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue (2016) (190)
- IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development (2011) (184)
- CNS insulin signaling in the control of energy homeostasis and glucose metabolism – from embryo to old age (2013) (182)
- Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis. (2010) (176)
- Hunger-Driven Motivational State Competition (2016) (174)
- IL-6 Regulates M2 Polarization and Local Proliferation of Adipose Tissue Macrophages in Obesity (2017) (172)
- Enhanced Stat3 Activation in POMC Neurons Provokes Negative Feedback Inhibition of Leptin and InsulinSignaling in Obesity (2009) (170)
- PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response. (2008) (163)
- Interleukin-6 signaling promotes alternative macrophage activation to limit obesity-associated insulin resistance and endotoxemia (2014) (162)
- Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism (2010) (162)
- N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response. (2018) (160)
- Regulation of metabolism by long, non-coding RNAs (2014) (158)
- Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis (2010) (157)
- Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis. (2011) (155)
- IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling. (2017) (150)
- Divergent roles of growth factors in the GnRH regulation of puberty in mice. (2010) (138)
- Neuronal control of peripheral insulin sensitivity and glucose metabolism (2017) (137)
- Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity (2009) (136)
- Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation. (2007) (134)
- CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity (2019) (133)
- Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation. (2010) (130)
- Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth (2008) (128)
- Activation of Stat3 signaling in AgRP neurons promotes locomotor activity. (2008) (127)
- Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. (2006) (121)
- Integrative neurobiology of energy homeostasis-neurocircuits, signals and mediators (2010) (121)
- T cell-intrinsic role of IL-6 signaling in primary and memory responses (2014) (121)
- Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. (2008) (114)
- Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia. (2005) (114)
- Single copy shRNA configuration for ubiquitous gene knockdown in mice (2005) (111)
- Insulin controls food intake and energy balance via NPY neurons (2017) (110)
- Hepatic Bax Inhibitor-1 Inhibits IRE1α and Protects from Obesity-associated Insulin Resistance and Glucose Intolerance* (2009) (110)
- Hepatic NF-κB essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis (2008) (109)
- Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity (2016) (107)
- Myeloid Cell-Restricted Insulin Receptor Deficiency Protects Against Obesity-Induced Inflammation and Systemic Insulin Resistance (2010) (106)
- Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD (2007) (106)
- The Sense of Smell Impacts Metabolic Health and Obesity. (2017) (105)
- Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells. (2014) (102)
- Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits. (2011) (98)
- Reversible gene knockdown in mice using a tight, inducible shRNA expression system (2007) (98)
- Delayed puberty but normal fertility in mice with selective deletion of insulin receptors from Kiss1 cells. (2013) (95)
- Forkhead transcription factors and ageing (2008) (95)
- Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance (2004) (92)
- Contraction-induced Interleukin-6 Gene Transcription in Skeletal Muscle Is Regulated by c-Jun Terminal Kinase/Activator Protein-1* (2012) (92)
- CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance. (2019) (91)
- Lipid signalling drives proteolytic rewiring of mitochondria by YME1L (2019) (90)
- Secondary consequences of beta cell inexcitability: identification and prevention in a murine model of K(ATP)-induced neonatal diabetes mellitus. (2009) (89)
- Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity (2016) (89)
- Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance. (2014) (84)
- IL-6/Stat3-Dependent Induction of a Distinct, Obesity-Associated NK Cell Subpopulation Deteriorates Energy and Glucose Homeostasis. (2017) (83)
- Dicer1–miR-328–Bace1 signalling controls brown adipose tissue differentiation and function (2016) (80)
- Rad GTPase Deficiency Leads to Cardiac Hypertrophy (2007) (80)
- Epidermal insulin/IGF‐1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation (2008) (75)
- An Obesity-Predisposing Variant of the FTO Gene Regulates D2R-Dependent Reward Learning (2015) (74)
- The role of ceramides in metabolic disorders: when size and localization matters (2020) (73)
- Obesogenic memory can confer long-term increases in adipose tissue but not liver inflammation and insulin resistance after weight loss (2016) (71)
- Electrical Inhibition of Identified Anorexigenic POMC Neurons by Orexin/Hypocretin (2007) (71)
- Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions. (2019) (68)
- The paradox of neuronal insulin action and resistance in the development of aging-associated diseases (2014) (68)
- VKORC1 deficiency in mice causes early postnatal lethality due to severe bleeding (2009) (68)
- Insulin regulates POMC neuronal plasticity to control glucose metabolism (2018) (67)
- Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer’s disease (2013) (65)
- Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation (2018) (63)
- Hypothalamic UDP Increases in Obesity and Promotes Feeding via P2Y6-Dependent Activation of AgRP Neurons (2015) (62)
- Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue (2016) (61)
- Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance. (2004) (60)
- Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure (2015) (59)
- Phosphoinositide-Dependent Kinase 1 Provides Negative Feedback Inhibition to Toll-Like Receptor-Mediated NF-κB Activation in Macrophages (2010) (59)
- gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor. (2006) (58)
- CNS-targets in control of energy and glucose homeostasis. (2009) (57)
- Muscle derived interleukin-6 increases exercise capacity by signaling in osteoblasts. (2020) (56)
- Transgenic and knockout mice in diabetes research: novel insights into pathophysiology, limitations, and perspectives. (2005) (56)
- The fat mass and obesity-associated (FTO) gene: Obesity and beyond? (2014) (55)
- IRS‐2 branch of IGF‐1 receptor signaling is essential for appropriate timing of myelination (2008) (54)
- PLRG1 Is an Essential Regulator of Cell Proliferation and Apoptosis during Vertebrate Development and Tissue Homeostasis (2009) (53)
- Food Intake Recruits Orosensory and Post-ingestive Dopaminergic Circuits to Affect Eating Desire in Humans. (2019) (51)
- Identification of tyrosine phosphorylation sites in human Gab-1 protein by EGF receptor kinase in vitro. (1999) (50)
- GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function (2020) (50)
- Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene (1994) (49)
- Obesity-Induced CerS 6-Dependent C 16 : 0 Ceramide Production Promotes Weight Gain and Glucose Intolerance (2018) (49)
- p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling. (2006) (47)
- Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance (2017) (47)
- POMC neuronal heterogeneity in energy balance and beyond: an integrated view (2021) (46)
- Gab-1-mediated IGF-1 Signaling in IRS-1-deficient 3T3 Fibroblasts* (2000) (46)
- A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle (2017) (45)
- AgRP innervation onto POMC neurons increases with age and is accelerated with chronic high-fat feeding in male mice. (2013) (44)
- The Sense of Smell Impacts Metabolic Health and Obesity (2018) (44)
- Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms. (2013) (44)
- Insulin/IGF-1 Controls Epidermal Morphogenesis via Regulation of FoxO-Mediated p63 Inhibition (2013) (44)
- Signal-dependent Control of Gluconeogenic Key Enzyme Genes through Coactivator-associated Arginine Methyltransferase 1* (2006) (43)
- PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding (2020) (43)
- NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons (2020) (43)
- Arcuate Nucleus-Dependent Regulation of Metabolism—Pathways to Obesity and Diabetes Mellitus (2021) (41)
- Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing. (2021) (41)
- Insulin-Dependent Activation of MCH Neurons Impairs Locomotor Activity and Insulin Sensitivity in Obesity. (2016) (40)
- Estrogen receptor-α and Sp1 interact in the induction of the low density lipoprotein-receptor (2003) (40)
- Insulin-Like Growth Factor-1 Controls Type 2 T Cell-Independent B Cell Response (2005) (40)
- Cutting Edge: Inhibition of IL-6 Trans-Signaling Protects from Malaria-Induced Lethality in Mice (2012) (40)
- Neurocircuits integrating hormone and nutrient signaling in control of glucose metabolism. (2008) (39)
- Role of tyrosine kinase signaling in estrogen-induced LDL receptor gene expression in HepG2 cells. (2002) (38)
- Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting (2021) (38)
- Central insulin signaling modulates hypothalamus–pituitary–adrenal axis responsiveness (2014) (38)
- Energy imbalance alters Ca2+ handling and excitability of POMC neurons (2017) (37)
- Antagonistic modulation of NPY/AgRP and POMC neurons in the arcuate nucleus by noradrenalin (2017) (36)
- Inhibition of P2Y6 Signaling in AgRP Neurons Reduces Food Intake and Improves Systemic Insulin Sensitivity in Obesity. (2017) (36)
- Ceramide synthase 4 regulates stem cell homeostasis and hair follicle cycling. (2015) (36)
- A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding. (2017) (36)
- Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism (2021) (36)
- VEGF and GLUT1 are highly heritable, inversely correlated and affected by dietary fat intake: Consequences for cognitive function in humans (2018) (35)
- Novel roles for JNK1 in metabolism (2010) (35)
- FTO gene variant modulates the neural correlates of visual food perception (2016) (35)
- MCH Neurons Regulate Permeability of the Median Eminence Barrier (2020) (34)
- Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and Engages a Pomc-Somatostatin-Growth Hormone Circuit (2018) (34)
- Hybrid Embryonic Stem Cell-Derived Tetraploid Mice Show Apparently Normal Morphological, Physiological, and Neurological Characteristics (2003) (31)
- TCPTP Regulates Insulin Signaling in AgRP Neurons to Coordinate Glucose Metabolism With Feeding (2018) (31)
- Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner. (2011) (31)
- Obesity promotes liver carcinogenesis via Mcl-1 stabilization independent of IL-6Rα signaling. (2013) (30)
- IGF-IR signaling attenuates the age-related decline of diastolic cardiac function. (2012) (30)
- Acute selective ablation of rat insulin promoter-expressing (RIPHER) neurons defines their orexigenic nature (2012) (29)
- Time-dependent assessment of stimulus-evoked regional dopamine release (2019) (29)
- p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1 (2018) (29)
- Maternal high-fat diet during lactation reprograms the dopaminergic circuitry in mice. (2020) (28)
- Meta-analysis of global metabolomic data identifies metabolites associated with life-span extension (2014) (27)
- Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo (2020) (26)
- Dwarfism in Mice Lacking Collagen-binding Integrins α2β1 and α11β1 Is Caused by Severely Diminished IGF-1 Levels* (2011) (25)
- Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity. (2018) (25)
- Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development. (2019) (25)
- Modulation of midbrain neurocircuitry by intranasal insulin (2019) (25)
- Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1. (2021) (24)
- K(ATP)-channel-dependent regulation of catecholaminergic neurons controls BAT sympathetic nerve activity and energy homeostasis. (2013) (24)
- Circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the VTA (2020) (23)
- -Active AKT signaling triggers CLL towards Richter's transformation via over-activation of Notch1. (2020) (22)
- Perinatal programming of metabolic diseases: role of insulin in the development of hypothalamic neurocircuits. (2013) (21)
- The role of insulin sensitivity and intranasally applied insulin on olfactory perception (2019) (20)
- Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus (2018) (19)
- The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation (2020) (19)
- Myeloid Cell–Restricted Insulin/IGF-1 Receptor Deficiency Protects against Skin Inflammation (2015) (19)
- Epidermal mTORC2 controls lipid synthesis and filaggrin processing in epidermal barrier formation. (2019) (17)
- Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity (2021) (16)
- Estrogen receptor-alpha and Sp1 interact in the induction of the low density lipoprotein-receptor. (2003) (16)
- Hepatic leptin receptor expression can partially compensate for IL-6Rα deficiency in DEN-induced hepatocellular carcinoma (2018) (15)
- m6A RNA methylation impacts fate choices during skin morphogenesis (2020) (14)
- Metabolism: Light on leptin link to lipolysis (2015) (13)
- Intestinal insulin/IGF1 signalling through FoxO1 regulates epithelial integrity and susceptibility to colon cancer (2019) (13)
- The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons. (2019) (13)
- Maternal Metabolic Programming of the Developing Central Nervous System: Unified Pathways to Metabolic and Psychiatric Disorders (2021) (12)
- Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance. (2019) (11)
- HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus (2022) (11)
- Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance (2021) (10)
- Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity (2021) (10)
- GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans. (2021) (10)
- Hemicentin-1 is an essential extracellular matrix component of the dermal–epidermal and myotendinous junctions (2021) (9)
- Novel approaches to the pharmacotherapy of obesity. (2013) (8)
- Erratum: A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding (Cell Metabolism (2017) 26(2) (375–393.e7) (S1550413117304345) (10.1016/j.cmet.2017.07.013)) (2017) (8)
- Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders (2022) (8)
- Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis (DOI:10.1016/j.cmet.2006.02.010) (2006) (7)
- MyomiRs-133a/b turn off the heat (2012) (7)
- Die Another Day: A Painless Path to Longevity (2014) (7)
- A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding. (2017) (7)
- Characterization of a postreceptor signaling defect that impairs cfos expression in cultured fibroblasts of a patient with insulin resistance. (2000) (6)
- Contribution of specific ceramides to obesity-associated metabolic diseases (2022) (6)
- Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition (2022) (6)
- Fischer et al. reply (2010) (6)
- Phosphoproteomics of the developing heart identifies PERM1 - An outer mitochondrial membrane protein. (2021) (6)
- Genetic manipulation of the insulin signalling cascade in mice--potential insight into the pathomechanism of type 2 diabetes. (2003) (6)
- Mapping leptin's link to reproduction. (2012) (5)
- Obesity: The need to eat—overruling the homeostatic control of feeding (2014) (5)
- Melanin-Concentrating Hormone-Dependent Control of Feeding: When Volume Matters. (2018) (5)
- A mouse model of neonatal diabetes caused by the K-ATP channel mutation Kir6.2-V59M (2008) (3)
- Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis (2022) (3)
- Sweet Mitochondrial Dynamics in VMH Neurons. (2016) (2)
- An antisense transcript transcribed from Irs2 locus contributes to the pathogenesis of hepatic steatosis in insulin resistance. (2021) (2)
- Circulating uridine dynamically and adaptively regulates food intake in humans (2023) (2)
- [Conditional mutagenesis--second generation knockout mice as models for internal diseases]. (1999) (2)
- Enhanced PIP3 signaling in POMC neurons causes diet-sensitive obesity as the consequence of neuronal silencing via KATP channel activation (2006) (1)
- NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition (2022) (1)
- Response to Comment on: Klöting et al. (2008) Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth: Diabetes 57:2074–2082 (2009) (1)
- Welcome to molecular metabolism! (2012) (1)
- Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation. (2023) (1)
- Selective ablation of hypothalamic POMC-expressing neurons leads to hyperphagia and weight gain (2006) (1)
- Author response: Energy imbalance alters Ca2+ handling and excitability of POMC neurons (2017) (1)
- Author response: Energy imbalance alters Ca2+ handling and excitability of POMC neurons (2017) (1)
- Modulation of Endocannabinoids by Caloric Restriction Is Conserved in Mice but Is Not Required for Protection from Acute Kidney Injury (2021) (1)
- Conditional disruption of IkB kinase 2 fails to prevent obesity-induced insulin resistance (2018) (1)
- Author response: T cell-intrinsic role of IL-6 signaling in primary and memory responses (2014) (1)
- Glucagon-like peptide 1 stimulates hypothalamic proopiomelanocortin neurons (Journal of Neuroscience (July 4, 2007) (7125-7129)) (2008) (0)
- Obesity and IL-6 promote liver carcinogenesis via Mcl-1 stabilization (2012) (0)
- EnhancedStat3ActivationinPOMCNeuronsProvokes NegativeFeedbackInhibitionofLeptinandInsulin SignalinginObesity (2009) (0)
- P2Y6 receptor signaling in natural killer cells impairs insulin sensitivity in obesity (2021) (0)
- The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation (2020) (0)
- Dopamine-inhibited POMC Drd2+ neurons in the ARC acutely regulate feeding and body temperature (2022) (0)
- NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons (2020) (0)
- Neuroendocrinology: Electromagnetogenetic Control over Feeding and Glucose Metabolism (2016) (0)
- Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus (2018) (0)
- Ceramide synthase 6 inhibition as a novel therapeutic approach for obesity and type 2 diabetes (2017) (0)
- Disruption of the PIP3-phosphatase Pten in Pomc neurons results in diet-sensitive obesity (2005) (0)
- NEUROTARGET – Targeting neurocircuits in obesity (2009) (0)
- 087 Metabolic and stress kinase signaling control skin barrier function: Implications for diabetic skin complications (2017) (0)
- Ribosomal subunit kinasE factor-stimulated transcri (2016) (0)
- p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1 (2018) (0)
- Circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the VTA (2020) (0)
- Author response: Antagonistic modulation of NPY/AgRP and POMC neurons in the arcuate nucleus by noradrenalin (2017) (0)
- Lipid signalling drives proteolytic rewiring of mitochondria by YME1L (2019) (0)
- Increased growth and elevated IGF-1 serum concentrations in mice with an adipose tissue specific deletion of the Igf-1 receptor (2007) (0)
- Highlight: The Biology of Aging: Mechanisms and Intervention (2010) (0)
- Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer’s disease (2011) (0)
- An Antisense Transcript Transcribed From Irs2 Locus Contributes to the Pathogenesis of Hepatic Steatosis in Insulin Resistance (2021) (0)
- Regulation of hypothalamic development by maternal nutrition (2015) (0)
- This information is current as in Obesity Proliferation of Adipose Tissue Macrophages IL-6 Regulates M 2 Polarization and Local (2017) (0)
- Role of myeloid cells specific PDK-1 in inflammation and obesity induced insulin resistance (2009) (0)
- Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes (2022) (0)
- The Metabolic Syndrome and Ovarian Dysfunction in Mice. (2010) (0)
- GLUT1 ablation in astrocytes paradoxically improves central and peripheral glucose metabolism via enhanced insulin-stimulated ATP release (2022) (0)
- Rad GTPase Deficiency Leads to Cardiac Hypertrophy Molecular Cardiology (2007) (0)
- 117 Epidermal barrier dysfunction upon loss of Insulin/IGF-1R signaling is compensated by p38α Map kinase stress signaling (2016) (0)
- A24 Hypothalamic expression of mutant huntingtin causes metabolic disturbances in mice (2010) (0)
- Macrophages inhibit adipogenesis of mesenchymal precursor cells via wnt-5a in humans (2009) (0)
- Dopamine-inhibited POMCDrd2+ neurons in the ARC acutely regulate feeding and body temperature (2022) (0)
- The role of insulin sensitivity and intranasally applied insulin on olfactory perception (2019) (0)
- Intestinal insulin/IGF1 signalling through FoxO1 regulates epithelial integrity and susceptibility to colon cancer (2019) (0)
- Brain morphology in lateral hypothalamus and dopaminergic midbrain predicts insulin receptor substrate (2017) (0)
- Peripheral insulin stimulation promotes tau phosphorylation in the CNS in vivo (2005) (0)
- Meta-analysis of global metabolomic data identifies metabolites associated with life-span extension (2013) (0)
- Brain glucose metabolism in obesity (2017) (0)
- Imunološki mehanizam nastanka upale visceralnog masnog tkiva u debljini kao podloge razvoja šećerne bolesti tipa 2 i njezinih kliničkih komplikacija (2016) (0)
- 345 Skin insulin resistance impairs skin barrier function in hyperglycemic and diabetic mouse models (2019) (0)
- 317 Healthy repair of injured skin requires mitochondrial repurposing in wound macrophages (2022) (0)
- Modulation of Endocannabinoids by Caloric Restriction is Conserved in Mice but is not Required for the Protection from Acute Kidney Injury (2021) (0)
- Obesity – A Matter of Motivation? (2022) (0)
- into Pathophysiology, Limitations, and Perspectives Transgenic and Knockout Mice in Diabetes Research: Novel Insights (2016) (0)
- Role of IGF-1 R / IR signaling in epidermal and vascular barrier function (2010) (0)
- Neuronal insulin resistance reduces Alzheimer-like pathology in Tg2576 mice independent of Foxo1 mediated transcription (2011) (0)
- The Immune Mechanisms of the Visceral Adipose Tissue Inflammation in Obesity as the Underlying Cause of Development of Diabetes Mellitus Type 2 and its Complication (2014) (0)
- Insulin resistance: A pathogenic link between cardiovascular risk factors and atherosclerosis (2000) (0)
- Lethality in Mice-Signaling Protects from Malaria-Induced Trans Cutting Edge : Inhibition of IL-6 (2012) (0)
- Habitual daily intake of a sweet and fatty snack modulates reward processing in humans. (2023) (0)
- Insights into Pathophysiology, Limitations, and Perspectives Transgenic and Knockout Mice in Diabetes Research: Novel (2015) (0)
- CNS IL-6 Trans-Signaling is enhanced in obese mice to improve anorexigenic and glucoregulatory effects of IL-6 (2016) (0)
- [The importance of the brain for the regulation of energy and glucose metabolism]. (2009) (0)
- Loss of IGF1R from oligodendrocytes ameliorates neuroinflammation without affecting cell survival (2014) (0)
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What Schools Are Affiliated With Jens Claus Brüning?
Jens Claus Brüning is affiliated with the following schools:
