Jerrold M. Olefsky

Jerrold M. Olefsky's AcademicInfluence.com Rankings

Jerrold M. Olefsky

Biology

#2078

World Rank

#3346

Historical Rank

#953

USA Rank

Endocrinology

World Rank

Historical Rank

USA Rank

biology Degrees

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Biology

Jerrold M. Olefsky's Degrees

Masters Medicine University of California, San Francisco
Bachelors Chemistry University of California, Berkeley

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Jerrold M. Olefsky's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Macrophages, inflammation, and insulin resistance. (2010) (2408)
GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects (2010) (1717)
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes (2007) (1653)
The cellular and signaling networks linking the immune system and metabolism in disease (2012) (1336)
Complex Distribution, Not Absolute Amount of Adiponectin, Correlates with Thiazolidinedione-mediated Improvement in Insulin Sensitivity* (2004) (1178)
Insulin sensitivity: modulation by nutrients and inflammation. (2008) (1175)
Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes (1996) (1084)
Inflammatory mechanisms linking obesity and metabolic disease (2017) (1063)
IKK-β links inflammation to obesity-induced insulin resistance (2005) (990)
Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle (2003) (979)
Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. (1994) (971)
A Subpopulation of Macrophages Infiltrates Hypertrophic Adipose Tissue and Is Activated by Free Fatty Acids via Toll-like Receptors 2 and 4 and JNK-dependent Pathways* (2007) (966)
IKK-beta links inflammation to obesity-induced insulin resistance. (2005) (925)
Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. (2008) (748)
The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. (2002) (732)
Inflammation and insulin resistance (2008) (719)
Inflammation and lipid signaling in the etiology of insulin resistance. (2012) (701)
Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity (2017) (701)
Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus. (1981) (674)
Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects. (1980) (671)
Acute and Chronic Effect of Insulin on Leptin Production in Humans: Studies In Vivo and In Vitro (1996) (627)
The Diabetes Prevention Program. Design and methods for a clinical trial in the prevention of type 2 diabetes. (1999) (625)
Effects of peroxisome proliferator-activated receptor δ on placentation, adiposity, and colorectal cancer (2001) (599)
Macrophages, immunity, and metabolic disease. (2014) (588)
Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. (2010) (579)
Neutrophils mediate insulin resistance in high fat diet fed mice via secreted elastase (2012) (578)
Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups. (2002) (562)
Mechanisms of insulin resistance in aging. (1983) (556)
Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance (2008) (544)
The Origins and Drivers of Insulin Resistance (2013) (539)
Treatment of insulin resistance with peroxisome proliferator–activated receptor γ agonists (2000) (531)
JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. (2007) (525)
Diabetes mellitus : a fundamental and clinical text (2004) (523)
The Effect of Insulin Treatment on Insulin Secretion and Insulin Action in Type II Diabetes Mellitus (1985) (523)
Effects of weight reduction on obesity. Studies of lipid and carbohydrate metabolism in normal and hyperlipoproteinemic subjects. (1974) (513)
A Fasting Inducible Switch Modulates Gluconeogenesis Via Activator-Coactivator Exchange (2008) (513)
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance (2015) (513)
Muscle-specific Pparg deletion causes insulin resistance (2003) (509)
PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3 (2004) (503)
Reappraisal of the role of insulin in hypertriglyceridemia. (1974) (500)
Inflamed fat: what starts the fire? (2005) (498)
Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. (2007) (489)
Regulation of metabolism by the innate immune system (2016) (487)
Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet–Induced Insulin Resistance (2011) (477)
Metabolic Effects of New Oral Hypoglycemic Agent CS-045 in NIDDM Subjects (1992) (448)
PPARδ regulates glucose metabolism and insulin sensitivity (2006) (447)
Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. (2009) (439)
JNK and Tumor Necrosis Factor-α Mediate Free Fatty Acid-induced Insulin Resistance in 3T3-L1 Adipocytes* (2005) (426)
A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. (2000) (422)
Nonketotic diabetes mellitus: insulin deficiency or insulin resistance? (1976) (415)
SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes (2008) (398)
Protein-tyrosine Phosphatase 1B Is a Negative Regulator of Insulin- and Insulin-like Growth Factor-I-stimulated Signaling* (1996) (398)
Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity (2014) (385)
Improved insulin-sensitivity in mice heterozygous for PPAR-γ deficiency (2000) (376)
SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. (2010) (370)
Decreased insulin binding to adipocytes and circulating monocytes from obese subjects. (1976) (353)
Increased Macrophage Migration Into Adipose Tissue in Obese Mice (2012) (353)
Lilly Lecture 1980: Insulin Resistance and Insulin Action: An In Vitro and In Vivo Perspective (1981) (341)
Cellular mechanisms of insulin resistance in polycystic ovarian syndrome. (1992) (329)
Postprandial Plasma-glucose and -insulin Responses to Different Complex Carbohydrates (1977) (327)
Mechanisms of insulin resistance in obesity and noninsulin-dependent (type II) diabetes. (1981) (320)
Nuclear Receptor Minireview Series* (2001) (318)
Effects of Weight Loss on Mechanisms of Hyperglycemia in Obese Non-Insulin-Dependent Diabetes Mellitus (1986) (317)
Metabolic Effects of Troglitazone Monotherapy in Type 2 Diabetes Mellitus (1998) (314)
An inhibitor of the protein kinases TBK1/IKKε improves obesity-related metabolic dysfunctions (2013) (311)
Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistance. (2002) (309)
Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus. (1982) (307)
The Insulin Receptor: Its Role in Insulin Resistance of Obesity and Diabetes (1976) (306)
A Gpr120 Selective Agonist Improves Insulin Resistance and Chronic Inflammation (2014) (299)
Protein Tyrosine Phosphatase 1B Interacts With the Activated Insulin Receptor (1996) (296)
PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. (2004) (295)
A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis. (1987) (294)
Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor. (1994) (279)
Increased Malonyl-CoA Levels in Muscle From Obese and Type 2 Diabetic Subjects Lead to Decreased Fatty Acid Oxidation and Increased Lipogenesis; Thiazolidinedione Treatment Reverses These Defects (2006) (275)
Insulin disrupts β-adrenergic signalling to protein kinase A in adipocytes (2005) (273)
Adenovirus-mediated chronic "hyper-resistinemia" leads to in vivo insulin resistance in normal rats. (2004) (268)
An Integrated View of Immunometabolism (2018) (266)
SirT1 Regulates Adipose Tissue Inflammation (2011) (263)
PPARγ and the Treatment of Insulin Resistance (2000) (260)
Effect of dexamethasone on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes. (1975) (260)
Structural differences between insulin receptors in the brain and peripheral target tissues. (1983) (257)
Insulin Treatment Reverses the Insulin Resistance of Type II Diabetes Mellitus (1982) (255)
PPARγ activation in adipocytes is sufficient for systemic insulin sensitization (2009) (255)
Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity (2011) (252)
Glycemic effects of intensive caloric restriction and isocaloric refeeding in noninsulin-dependent diabetes mellitus. (1985) (252)
Demonstration of insulin resistance in untreated adult onset diabetic subjects with fasting hyperglycemia. (1975) (251)
Plasma Glucose and Insulin Responses to Orally Administered Simple and Complex Carbohydrates (1976) (250)
Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction. (1994) (241)
Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects. (1987) (240)
Metabolic Effects of Troglitazone on Fructose-Induced Insulin Resistance in the Rat (1994) (239)
Activated Phosphatidylinositol 3-Kinase Is Sufficient to Mediate Actin Rearrangement and GLUT4 Translocation in 3T3-L1 Adipocytes* (1996) (238)
The Acute and Chronic Effects of Sulfonylurea Therapy in Type II Diabetic Subjects (1984) (235)
Protein Phosphatase 2A Negatively Regulates Insulin's Metabolic Signaling Pathway by Inhibiting Akt (Protein Kinase B) Activity in 3T3-L1 Adipocytes (2004) (234)
A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis (2012) (232)
Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling (231)
Insulin Binding in Diabetes: Relationships with Plasma Insulin Levels and Insulin Sensitivity (1977) (225)
Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases. (2011) (225)
PPARdelta regulates glucose metabolism and insulin sensitivity. (2006) (224)
Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. (2012) (222)
Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists. (2000) (220)
Brain PPARγ Promotes Obesity and is Required for the Insulin–Sensitizing Effect of Thiazolidinediones (2011) (219)
Functional Heterogeneity of CD11c-positive Adipose Tissue Macrophages in Diet-induced Obese Mice* (2010) (214)
Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss. (1988) (212)
Mechanisms of the ability of insulin to activate the glucose-transport system in rat adipocytes. (1978) (206)
LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes (2015) (206)
Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance (2016) (201)
FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages (2010) (200)
Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport (2011) (198)
Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer (2014) (197)
TNF-α-Induced Insulin Resistance In Vivo and Its Prevention by Troglitazone (1997) (197)
Induction of Insulin Resistance In Vivo by Amylin and Calcitonin Gene–Related Peptide (1990) (194)
Effects of sulfonylurea therapy on insulin binding to mononuclear leukocytes of diabetic patients. (1976) (192)
Insulin-Induced GLUT4 Translocation Involves Protein Kinase C-λ-Mediated Functional Coupling between Rab4 and the Motor Protein Kinesin (2003) (191)
Role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus. (1988) (190)
Relationship Between Fasting Plasma Insulin Level and Resistance to Insulin-Mediated Glucose Uptake in Normal and Diabetic Subjects (1973) (190)
Effects of troglitazone on blood concentrations of plasminogen activator inhibitor 1 in patients with type 2 diabetes and in lean and obese normal subjects. (2000) (189)
Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. (2011) (183)
Negative Feedback Regulation and Desensitization of Insulin- and Epidermal Growth Factor-stimulated p21ras Activation (*) (1995) (183)
GnRH Activates ERK1/2 Leading to the Induction of c-fos and LHβ Protein Expression in LβT2 Cells (2002) (182)
Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation. (1994) (181)
The Tumor Suppressor PTEN Negatively Regulates Insulin Signaling in 3T3-L1 Adipocytes* (2000) (180)
Metabolic Consequences of Very-Low-Calorie Diet Therapy in Obese Non-insulin-dependent Diabetic and Nondiabetic Subjects (1986) (179)
In vitro studies on the action of CS-045, a new antidiabetic agent. (1990) (179)
The effects of spontaneous obesity on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes. (1976) (179)
β-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic β cells (2008) (176)
Glucose and insulin co-regulate the glucose transport system in primary cultured adipocytes. A new mechanism of insulin resistance. (1987) (175)
Inflammation in obesity, diabetes, and related disorders (2022) (170)
A structurally abnormal insulin causing human diabetes (1979) (168)
Effects of insulin incubation on insulin binding, glucose transport, and insulin degradation by isolated rat adipocytes. Evidence for hormone-induced desensitization at the receptor and postreceptor level. (1980) (167)
Involvement of Both Gq/11 and Gs Proteins in Gonadotropin-releasing Hormone Receptor-mediated Signaling in LβT2 Cells* (2002) (167)
Effects of Streptozotocin-induced Diabetes on Insulin Binding, Glucose Transport, and Intracellular Glucose Metabolism in Isolated Rat Adipocytes (1979) (164)
Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. (2005) (162)
G Alpha-q/11 Protein Plays a Key Role in Insulin-Induced Glucose Transport in 3T3-L1 Adipocytes (1999) (160)
Effects of Oral Fructose in Normal, Diabetic, and Impaired Glucose Tolerance Subjects (1980) (160)
Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation. (2002) (158)
The effects of acute and chronic dexamethasone administration on insulin binding to isolated rat hepatocytes and adipocytes. (1975) (156)
Cellular and molecular mechanisms of non-insulin dependent diabetes mellitus. (1996) (156)
Effect of Obesity on Insulin Resistance in Normal Subjects and Patients With NIDDM (1995) (154)
Insulin-stimulated GLUT4 Translocation Is Mediated by a Divergent Intracellular Signaling Pathway (*) (1995) (152)
Insulin and Insulin-like Growth Factor I Receptors Utilize Different G Protein Signaling Components* (2001) (152)
Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency. (2000) (152)
Effects of lysosomotropic agents on insulin interactions with adipocytes. Evidence for a lysosomal pathway for insulin processing and degradation. (1979) (150)
Principles of Nutrition and Dietary Recommendations for Individuals with Diabetes Mellitus: 1979 (1979) (149)
Decreased insulin binding to lymphocytes from diabetic subjects. (1974) (148)
Grb10 Interacts Differentially with the Insulin Receptor, Insulin-like Growth Factor I Receptor, and Epidermal Growth Factor Receptor via the Grb10 Src Homology 2 (SH2) Domain and a Second Novel Domain Located between the Pleckstrin Homology and SH2 Domains* (1998) (147)
Interaction of a GRB-IR Splice Variant (a Human GRB10 Homolog) with the Insulin and Insulin-like Growth Factor I Receptors (1996) (147)
Effects of fasting on insulin binding, glucose transport, and glucose oxidation in isolated rat adipocytes: relationships between insulin receptors and insulin action. (1976) (146)
NCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids (2013) (146)
GPR43 Potentiates β-Cell Function in Obesity (2015) (142)
Moderate ethanol ingestion and plasma triglyceride levels. A study in normal and hypertriglyceridemic persons. (1974) (141)
Pro‐Inflammatory macrophages increase in skeletal muscle of high fat‐Fed mice and correlate with metabolic risk markers in humans (2014) (141)
Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity. (2019) (140)
Decreased susceptibility to fatty acid-induced peripheral tissue insulin resistance in women. (2001) (139)
Influence of hyperglycemia on insulin's in vivo effects in type II diabetes. (1984) (139)
The Insulin Receptor: A Multifunctional Protein (1990) (139)
Characterization of Distinct Subpopulations of Hepatic Macrophages in HFD/Obese Mice (2014) (139)
The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities (2019) (135)
PPAR gamma and the treatment of insulin resistance. (2000) (134)
Nuclear translocation of the insulin receptor. A possible mediator of insulin's long term effects. (1987) (133)
Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression (1994) (133)
Inhibition of Phosphatidylinositol 3-Kinase Activity by Adenovirus-mediated Gene Transfer and Its Effect on Insulin Action* (1998) (131)
Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes. (2008) (130)
β-Arrestin-mediated Recruitment of the Src Family Kinase Yes Mediates Endothelin-1-stimulated Glucose Transport* (2001) (129)
Factitious hypoglycemia. Diagnosis by measurement of serum C-peptide immunoreactivity and insulin-binding antibodies. (1977) (128)
Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity (2015) (126)
TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. (2014) (126)
Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein (2001) (126)
FOXO1 Transrepresses Peroxisome Proliferator-activated Receptor γ Transactivation, Coordinating an Insulin-induced Feed-forward Response in Adipocytes* (2009) (125)
Rates of noninsulin-mediated glucose uptake are elevated in type II diabetic subjects. (1985) (124)
Effects of Age and Obesity on Insulin Binding to Isolated Adipocytes1212 (1975) (122)
The signaling pathway coupling epidermal growth factor receptors to activation of p21ras. (1994) (121)
Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity. (1994) (119)
Effect of Troglitazone on Leptin Production: Studies In Vitro and in Human Subjects (1996) (118)
The Fractalkine/CX3CR1 System Regulates β Cell Function and Insulin Secretion (2013) (118)
Effect of a High Carbohydrate Diet on Insulin Binding to Adipocytes and on Insulin Action in vivo in Man (1979) (117)
Insulin resistance due to a defect distal to the insulin receptor: demonstration in a patient with leprechaunism. (1978) (117)
Insulin Induces Progressive Insulin Resistance in Cultured Rat Adipocytes: Sequential Effects at Receptor and Multiple Postreceptor Sites (1986) (116)
Insulin and Glucose Responses to Identical Oral Glucose Tolerance Tests Performed Forty-eight Hours Apart (1974) (116)
Bone marrow–specific Cap gene deletion protects against high-fat diet–induced insulin resistance (2007) (116)
Evidence for recycling of insulin receptors in isolated rat adipocytes. (1981) (116)
Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction. (1994) (115)
Role of Glucose Transport in the Postreceptor Defect of Non-insulin-dependent Diabetes Mellitus (1982) (115)
Suppression of PPAR-γ attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes (2007) (113)
Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects. (1988) (112)
Demonstration of insulin receptors and modulation of alkaline phosphatase activity by insulin in rat osteoblastic cells. (1986) (112)
Insulin Binding to Isolated Human Adipocytes (1974) (111)
Female rats do not exhibit free fatty acid-induced insulin resistance. (2002) (110)
Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways. (1996) (110)
Protein Phosphatase 2A Forms a Molecular Complex with Shc and Regulates Shc Tyrosine Phosphorylation and Downstream Mitogenic Signaling (2002) (109)
Myosin 5a Is an Insulin-Stimulated Akt2 (Protein Kinase Bβ) Substrate Modulating GLUT4 Vesicle Translocation (2007) (108)
Blood-Brain Glucose Transfer In Diabetes Mellitus: Decreased Number of Glucose Transporters at Blood-Brain Barrier (1986) (106)
Kinetics of In Vivo Muscle Insulin-Mediated Glucose Uptake in Human Obesity (1990) (106)
Exosomes as mediators of intercellular crosstalk in metabolism. (2021) (105)
Diabetes due to secretion of an abnormal insulin. (1980) (105)
Variance-modeled posterior inference of microarray data: detecting gene-expression changes in 3T3-L1 adipocytes (2004) (105)
Cellular effects of small molecule PTP1B inhibitors on insulin signaling. (2003) (104)
A comparison of troglitazone and metformin on insulin requirements in euglycemic intensively insulin-treated type 2 diabetic patients. (1999) (104)
The Proto-oncogene Product p120cbl Links c-Src and Phosphatidylinositol 3′-Kinase to the Integrin Signaling Pathway* (1997) (102)
Induction of hypertriglyceridemia by a low-fat diet. (1976) (102)
High Fat Diet Causes Depletion of Intestinal Eosinophils Associated with Intestinal Permeability (2015) (102)
Mechanism of the postreceptor defect in insulin action in human obesity. Decrease in glucose transport system activity. (1981) (101)
VAMPIRE microarray suite: a web-based platform for the interpretation of gene expression data (2005) (100)
Cellular insulin resistance in adipocytes from obese polycystic ovary syndrome subjects involves adenosine modulation of insulin sensitivity. (1997) (99)
Exercise and thiazolidinedione therapy normalize insulin action in the obese Zucker fatty rat. (2000) (99)
Postprandial Hormonal Responses to Different Types of Complex Carbohydrate in Individuals with Impaired Glucose Tolerance (1980) (98)
Kinetics of Insulin Action In Vivo: Identification of Rate-Limiting Steps (1995) (98)
Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators. (2009) (97)
Direct in vitro effect of a sulfonylurea to increase human fibroblast insulin receptors. (1980) (97)
Membrane-targeted Phosphatidylinositol 3-Kinase Mimics Insulin Actions and Induces a State of Cellular Insulin Resistance* (1999) (96)
SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis (2008) (96)
Stressed out about obesity and insulin resistance (2006) (96)
Chronic endothelin-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytes. (2001) (96)
Mechanisms of decreased insulin responsiveness of large adipocytes. (1977) (95)
Surface binding and rates of internalization of 125I-insulin in adipocytes and IM-9 lymphocytes. (1982) (95)
GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation (2004) (93)
Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus. (1991) (93)
Further Evidence that Insulin Resistance Exists in Patients with Chemical Diabetes (1974) (93)
Removal of insulin by perfused rat liver: effect of concentration. (1975) (93)
Relationship between in vivo insulin resistance and decreased insulin receptors in obese man. (1979) (92)
Chronic endothelin-1 treatment leads to insulin resistance in vivo. (2003) (91)
Insulin receptor kinase activity in rat liver. Regulation by fasting and high carbohydrate feeding. (1985) (91)
FoxO1 Haploinsufficiency Protects Against High-Fat Diet–Induced Insulin Resistance With Enhanced Peroxisome Proliferator–Activated Receptor γ Activation in Adipose Tissue (2009) (90)
Omega 3 fatty acids and GPR120. (2012) (90)
Effect of experimental hyperinsulinemia on insulin binding and glucose transport in isolated rat adipocytes. (1978) (90)
Cdc42 Is a Rho GTPase Family Member That Can Mediate Insulin Signaling to Glucose Transport in 3T3-L1 Adipocytes* (2003) (89)
Cellular mechanisms of insulin resistance in non-insulin-dependent (type II) diabetes. (1988) (89)
Insulin receptors of skeletal muscle: specific insulin binding sites and demonstration of decreased numbers of sites in obese rats. (1976) (88)
The effects of dietary carbohydrate content on insulin binding and glucose metabolism by isolated rat adipocytes. (1978) (87)
Transdominant inhibition of tyrosine kinase activity in mutant insulin/insulin-like growth factor I hybrid receptors. (1991) (87)
"Tertiary" hyperparathyroidism and apparent "cure" of vitamin-D-resistant rickets after removal of an ossifying mesenchymal tumor of the pharynx. (1972) (86)
Platelet-derived Growth Factor Inhibits Insulin Stimulation of Insulin Receptor Substrate-1-associated Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes without Affecting Glucose Transport* (1998) (86)
Glucose-induced phosphorylation of the insulin receptor. Functional effects and characterization of phosphorylation sites. (1996) (85)
Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells. (2002) (85)
Adenovirus-mediated adiponectin expression augments skeletal muscle insulin sensitivity in male Wistar rats. (2005) (85)
Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action (2005) (85)
Short-term Regulation of Insulin Receptor Affinity in Man (1980) (83)
An SH2 Domain-Containing 5′ Inositolphosphatase Inhibits Insulin-Induced GLUT4 Translocation and Growth Factor-Induced Actin Filament Rearrangement (1999) (83)
Skeletal muscle peroxisome proliferator- activated receptor-gamma expression in obesity and non- insulin-dependent diabetes mellitus. (1998) (83)
MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice. (2021) (82)
The human lymphocyte: a model for the study of insulin-receptor interaction. (1974) (82)
Mechanisms of insulin resistance in non-insulin-dependent (type II) diabetes. (1985) (82)
Insulin-Receptor Autophosphorylation and Endogenous Substrate Phosphorylation in Human Adipocytes From Control, Obese, and NIDDM Subjects (1990) (82)
The effects of intracellular calcium depletion on insulin signaling in 3T3-L1 adipocytes. (2002) (82)
Localization of the insulin receptor binding sites for the SH2 domain proteins p85, Syp, and GAP. (1994) (81)
Kinetics of Insulin-Mediated and Non-Insulin-Mediated Glucose Uptake in Humans (1990) (81)
Glucocorticoids and Thiazolidinediones Interfere with Adipocyte-mediated Macrophage Chemotaxis and Recruitment* (2009) (81)
Evidence for insulin-induced internalization and degradation of insulin receptors in rat adipocytes. (1982) (81)
Thiazolidinedione treatment prevents free fatty acid-induced insulin resistance in male wistar rats. (2001) (80)
Prospects for research in diabetes mellitus. (2001) (80)
Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling (2017) (80)
Inhibition of mitochondrial Na+-Ca2+ exchanger increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets. (2003) (80)
Does hyperglycaemia or hyperinsulinaemia characterise the patient with chemical diabetes? (1972) (79)
A functional assessment of insulin/insulin-like growth factor-I hybrid receptors. (1995) (79)
Regulation of Receptor Tyrosine Kinase Signaling by GRKs and β-Arrestins (2007) (79)
The Metabolic Clearance of Insulin and the Feedback Inhibition of Insulin Secretion Are Altered with Aging (1985) (79)
Insulin Induces Heterologous Desensitization of G Protein-Coupled Receptor and Insulin-Like Growth Factor I Signaling by Downregulating β-Arrestin-1 (2002) (79)
Evidence for decreased splanchnic glucose uptake after oral glucose administration in non-insulin-dependent diabetes mellitus. (1997) (78)
Properties of a human insulin receptor with a COOH-terminal truncation. I. Insulin binding, autophosphorylation, and endocytosis. (1988) (78)
G protein-coupled receptors as targets for anti-diabetic therapeutics (2016) (77)
Selective modulation of promoter recruitment and transcriptional activity of PPARgamma. (2007) (77)
Insulin Stimulates the Tyrosine Dephosphorylation of pp125 Focal Adhesion Kinase (*) (1995) (76)
Adenovirus-mediated overexpression of IRS-1 interacting domains abolishes insulin-stimulated mitogenesis without affecting glucose transport in 3T3-L1 adipocytes (1997) (76)
Insulin binding in human pregnancy: comparisons to the postpartum, luteal, and follicular states. (1981) (76)
G Protein-Coupled Receptor Kinase 2 Mediates Endothelin-1-Induced Insulin Resistance via the Inhibition of Both Gαq/11 and Insulin Receptor Substrate-1 Pathways in 3T3-L1 Adipocytes (2005) (75)
Topiramate is an insulin-sensitizing compound in vivo with direct effects on adipocytes in female ZDF rats. (2005) (75)
Insulin receptors with defective tyrosine kinase inhibit normal receptor function at the level of substrate phosphorylation. (1988) (74)
Regulation of protein tyrosine phosphatases by insulin and insulin-like growth factor I. (1993) (73)
Regulation of glucose transport in cultured muscle cells by novel hypoglycemic agents. (1995) (73)
Comparison of the intracellular itineraries of insulin-like growth factor-I and insulin and their receptors in Rat-1 fibroblasts. (1994) (71)
Localization of the Insulin-like Growth Factor I Receptor Binding Sites for the SH2 Domain Proteins p85, Syp, and GTPase Activating Protein (*) (1995) (71)
Fetuin-A: the missing link in lipid-induced inflammation (2012) (71)
Insulin activation of insulin receptor tyrosine kinase in intact rat adipocytes. An in vitro system to measure histone kinase activity of insulin receptors activated in vivo. (1986) (71)
Endothelin-1-induced GLUT4 Translocation Is Mediated via Gαq/11 Protein and Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes* (1999) (70)
Chronic tissue inflammation and metabolic disease (2021) (70)
Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. (2013) (70)
Mutation of the two carboxyl-terminal tyrosines results in an insulin receptor with normal metabolic signaling but enhanced mitogenic signaling properties. (1991) (69)
Nerve growth factor processing and trafficking events following TrkA-mediated endocytosis. (1998) (68)
Insulin treatment reverses the postreceptor defect in adipocyte 3-O-methylglucose transport in type II diabetes mellitus. (1983) (67)
Impaired insulin secretion in a mouse model of ataxia telangiectasia. (2007) (67)
Lack of in vivo insulin resistance in controlled insulin-dependent, type I, diabetic patients. (1984) (67)
Evidence for an insulin receptor substrate 1 independent insulin signaling pathway that mediates insulin-responsive glucose transporter (GLUT4) translocation. (1996) (65)
Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes. (2009) (65)
Lentiviral short hairpin ribonucleic acid-mediated knockdown of GLUT4 in 3T3-L1 adipocytes. (2006) (65)
The small guanosine triphosphate-binding protein Rab4 is involved in insulin-induced GLUT4 translocation and actin filament rearrangement in 3T3-L1 cells. (1997) (64)
β-Arrestin-1 Competitively Inhibits Insulin-Induced Ubiquitination and Degradation of Insulin Receptor Substrate 1 (2004) (64)
GPR105 Ablation Prevents Inflammation and Improves Insulin Sensitivity in Mice with Diet-Induced Obesity (2012) (64)
Pathogenesis of Insulin Resistance and Hyperglycemia in Non-Insulin-Dependent Diabetes Mellitus (1985) (64)
Liver-specific p70 S6 Kinase Depletion Protects against Hepatic Steatosis and Systemic Insulin Resistance* (2012) (63)
Semisynthesis and biological activity of porcine [LeuB24]insulin and [LeuB25]insulin. (1980) (62)
Insulin and insulin-like growth factor-I signal transduction requires p21ras. (1994) (62)
Quantitative Proteomic and Functional Analysis of Liver Mitochondria from High Fat Diet (HFD) Diabetic Mice* (2013) (62)
Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes. (2000) (60)
Insensitivity of large rat adipocytes to the antilipolytic effects of insulin. (1977) (60)
Spatial Cognition in Adult and Aged Mice Exposed to High-Fat Diet (2015) (60)
The Functional Role of CrkII in Actin Cytoskeleton Organization and Mitogenesis* (1999) (59)
Insulin Binding to Adipocytes: Evidence for Functionally Distinct Receptors (1978) (59)
Mechanisms of the Kinetic Defect in Insulin Action in Obesity and NIDDM (1997) (59)
Long-term regulation of adipocyte glucose transport capacity by circulating insulin in rats. (1978) (59)
Insulin resistance and diabetes due to a genetic defect in insulin receptors. (1982) (59)
Omega-3 fatty acids reduce obesity-induced tumor progression independent of GPR120 in a mouse model of postmenopausal breast cancer (2014) (58)
Disruption of Microtubules Ablates the Specificity of Insulin Signaling to GLUT4 Translocation in 3T3-L1 Adipocytes* (2005) (57)
Metabolic effects of increased caloric intake in man. (1975) (57)
Suppression of Egr‐1 transcription through targeting of the serum response factor by oncogenic H‐Ras (2006) (56)
Internalization and molecular processing of insulin receptors in isolated rat adipocytes. (1982) (56)
Sex Difference in the Kinetics of Triglyceride Metabolism in Normal and Hypertriglyceridaemic Human Subjects (1974) (56)
Restriction-Fragment–Length Polymorphism in Insulin-Receptor Gene and Insulin Resistance in NIDDM (1988) (56)
Insulin receptor down-regulation is linked to an insulin-induced postreceptor defect in the glucose transport system in rat adipocytes. (1985) (55)
Metabolic effects of troglitazone therapy in type 2 diabetic, obese, and lean normal subjects. (2000) (55)
Association of the Insulin Receptor with Phospholipase C-γ (PLCγ) in 3T3-L1 Adipocytes Suggests a Role for PLCγ in Metabolic Signaling by Insulin* (1998) (54)
Regulation of insulin receptors: evidence for involvement of an endocytotic internalization pathway. (1980) (54)
LTB4 causes macrophage–mediated inflammation and directly induces insulin resistance in obesity (2015) (54)
Expression of Dominant Negative Mutant SHPTP2 Attenuates Phosphatidylinositol 3′-Kinase Activity via Modulation of Phosphorylation of Insulin Receptor Substrate-1 (*) (1996) (54)
The trafficking and processing of insulin and insulin receptors in cultured rat hepatocytes. (1987) (54)
Insulin Binding, Internalization, and Insulin Receptor Regulation in Fibroblasts from Type II, Non-insulin-dependent Diabetic Subjects (1981) (54)
In Vivo Deactivation of Peripheral, Hepatic, and Pancreatic Insulin Action in Man (1982) (53)
The 2011–2016 Transdisciplinary Research on Energetics and Cancer (TREC) Initiative: Rationale and Design (2013) (53)
Effects of Nonesterified Fatty Acids on Glucose Metabolism After Glucose Ingestion (1997) (53)
GnRH activates ERK1/2 leading to the induction of c-fos and LHbeta protein expression in LbetaT2 cells. (2002) (53)
A noninvasive method to measure splanchnic glucose uptake after oral glucose administration. (1995) (53)
Mechanisms of insulin resistance in experimental hyperinsulinemic dogs. (1998) (53)
Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity (2018) (52)
Acute effects of troglitazone on in vivo insulin action in normal rats. (1995) (52)
Neuronal Sirt1 Deficiency Increases Insulin Sensitivity in Both Brain and Peripheral Tissues* (2013) (52)
G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes. (2005) (52)
Metabolic effects of troglitazone on fat-induced insulin resistance in the rat. (1995) (51)
Insulin resistance and diabetes due to different mutations in the tyrosine kinase domain of both insulin receptor gene alleles. (1991) (51)
G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice. (2012) (50)
The endocytotic-internalization pathway of insulin metabolism: relationship to insulin degradation and activation of glucose transport. (1980) (50)
Fat Talks, Liver and Muscle Listen (2008) (50)
Interactions Between Insulin and Its Receptors After the Initial Binding Event: Functional Heterogeneity and Relationships to Insulin Degradation (1979) (50)
Effects of age and obesity on insulin binding to isolated adipocytes. (1975) (49)
Comparison of 125I-Insulin Binding and Degradation to Isolated Rat Hepatocytes and Liver Membranes (1975) (49)
Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3). (2004) (49)
Insulin receptor kinase following internalization in isolated rat adipocytes. (1987) (48)
Insulin-stimulated glucose transport in human adipocytes. (1979) (48)
Effect of heterozygous PPARγ deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding (2003) (47)
Adipocyte glycogen synthase and pyruvate dehydrogenase in obese and type II diabetic subjects. (1986) (47)
Regulation of receptor tyrosine kinase signaling by GRKs and beta-arrestins. (2007) (47)
NPXY motif in the insulin-like growth factor-I receptor is required for efficient ligand-mediated receptor internalization and biological signaling. (1994) (47)
TAZ Is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance. (2019) (47)
Insulin's effect on glucose oxidation independent of glucose transport. (1976) (47)
Modulation of insulin secretion by insulin and glucose in type II diabetes mellitus. (1985) (47)
Inverse Regulation of Inflammation and Mitochondrial Function in Adipose Tissue Defines Extreme Insulin Sensitivity in Morbidly Obese Patients (2013) (47)
Postprandial plasma triglyceride and cholesterol responses to a low-fat meal. (1976) (46)
Troglitazone prevents hyperglycemia-induced but not glucosamine-induced insulin resistance. (1998) (46)
Signal transduction pathways leading to insulin-induced early gene induction. (1995) (46)
Evidence for Two Independent Pathways of Insulin-Receptor Internalization in Hepatocytes and Hepatoma Cells (1988) (46)
Suppression of PPAR-gamma attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes. (2007) (46)
Protein Phosphatase-2Cα as a Positive Regulator of Insulin Sensitivity through Direct Activation of Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes* (2004) (45)
The effect of ten days of fasting on various aspects of carbohydrate metabolism in obese diabetic subjects with significant fasting hyperglycemia. (1978) (45)
Quantification of plasma cholesterol and triglyceride levels in hypercholesterolemic subjects receiving ascorbic acid supplements. (1975) (45)
Variation in the gene for muscle-specific AMP deaminase is associated with insulin clearance, a highly heritable trait. (2005) (45)
C/EBPα regulates macrophage activation and systemic metabolism. (2014) (44)
In vivo stimulation of the insulin receptor kinase in human skeletal muscle. Correlation with insulin-stimulated glucose disposal during euglycemic clamp studies. (1991) (44)
Functional Roles of the Shc Phosphotyrosine Binding and Src Homology 2 Domains in Insulin and Epidermal Growth Factor Signaling* (1996) (43)
β-Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of β2 adrenergic receptor Gαs signaling in 3T3-L1 adipocytes (2002) (43)
Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression (2011) (43)
Dissection of the growth versus metabolic effects of insulin and insulin-like growth factor-I in transfected cells expressing kinase-defective human insulin receptors. (1990) (43)
p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity (2012) (42)
Substrate specificities of insulin and epidermal growth factor receptor kinases. (1985) (42)
IKKɛ: A Bridge between Obesity and Inflammation (2009) (42)
Biochemical and functional heterogeneity of rat adipocyte glucose transporters. (1986) (42)
Characterization of Insulin-induced Receptor Loss and Evidence for Internalization of the Insulin Receptor (1981) (41)
Insulin-induced β-Arrestin1 Ser-412 Phosphorylation Is a Mechanism for Desensitization of ERK Activation by Gαi-coupled Receptors* (2005) (41)
Locating the Site(s) of Insulin Resistance in Patients with Nonketotic Diabetes Mellitus (1976) (41)
Free fatty acids induce Lhb mRNA but suppress Fshb mRNA in pituitary LβT2 gonadotropes and diet-induced obesity reduces FSH levels in male mice and disrupts the proestrous LH/FSH surge in female mice. (2013) (41)
Insulin activates p21Ras and guanine nucleotide releasing factor in cells expressing wild type and mutant insulin receptors. (1993) (41)
Effects of Insulin and Insulin-like Agents on the Glucose Transport System of Cultured Human Fibroblasts (1981) (40)
The effects of acute and chronic starvation on insulin binding to isolated human adipocytes. (1979) (39)
Lack of Effect of Islet Amyloid Polypeptide in Causing Insulin Resistance in Conscious Dogs During Euglycemic Clamp Studies (1991) (39)
Retroendocytosis of insulin in rat adipocytes. (1986) (39)
The role of the glucose transport system in the postreceptor defect in insulin action associated with human aging. (1984) (39)
Mechanism of Defective Insulin-Receptor Kinase Activity in NIDDM: Evidence for Two Receptor Populations (1989) (39)
Diabetes: Gene therapy for rats and mice (2000) (39)
Photoaffinity Labeling of Insulin Receptors in Viable Cultured Human Lymphocytes: Demonstration of Receptor Shedding and Degradation (1982) (39)
Increased plasma glucose and insulin responses to high-carbohydrate feedings in normal subjects. (1974) (38)
Relative expression of insulin receptor isoforms does not differ in lean, obese, and noninsulin-dependent diabetes mellitus subjects. (1993) (38)
Insulin Signals to Prenyltransferases via the Shc Branch of Intracellular Signaling* (2001) (38)
Relationship between heterogeneity of insulin responses and insulin resistance in normal subjects and patients with chemical diabetes (1977) (37)
Coupling of insulin receptors to glucose transport: a temperature-dependent time lag in activation of glucose transport. (1979) (37)
POTENTIATION OF INSULIN BINDING AND INSULIN ACTION BY PURIFIED PORCINE RELAXIN * (1982) (37)
Insulin resistance in humans. (1982) (37)
Blockade of α4 Integrin Signaling Ameliorates the Metabolic Consequences of High-Fat Diet–Induced Obesity (2008) (37)
A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats. (2010) (37)
Insulin action kinetics in adipocytes from obese and noninsulin-dependent diabetes mellitus subjects: identification of multiple cellular defects in glucose transport. (1991) (37)
Insulin-stimulated Glucose Transport Minireview Series* (1999) (37)
Glucose kinetics in leprechaunism: accelerated fasting due to insulin resistance. (1980) (37)
Mechanism of hypertriglyceridaemia in diabetic patients with fasting hyperglycaemia (1980) (36)
Functional characterization of hybrid receptors composed of a truncated insulin receptor and wild type insulin-like growth factor 1 or insulin receptors. (1995) (36)
Topiramate treatment causes skeletal muscle insulin sensitization and increased Acrp30 secretion in high-fat-fed male Wistar rats. (2005) (36)
The impact of sulfonylurea treatment upon the mechanisms responsible for the insulin resistance in type II diabetes. (1984) (36)
Effects of growth and insulin treatment on the levels of insulin receptors and their mRNA in Hep G2 cells. (1989) (35)
Mutation of the two carboxyl-terminal tyrosines in the insulin receptor results in enhanced activation of mitogen-activated protein kinase. (1994) (35)
Phosphatidylinositol 3-kinase is necessary and sufficient for insulin-stimulated stress fiber breakdown. (1996) (35)
Src homology 2 domains of protein tyrosine phosphatase are associated in vitro with both the insulin receptor and insulin receptor substrate‐1 via different phosphotyrosine motifs (1994) (35)
p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. (2016) (35)
The G12 coupled thrombin receptor stimulates mitogenesis through the Shc SH2 domain (1997) (35)
Decreased Activation Rate of Insulin-Stimulated Glucose Transport in Adipocytes From Obese Subjects (1989) (35)
Defective insulin receptor function in down-regulated HepG2 cells. (1990) (34)
APPLied mechanics: uncovering how adiponectin modulates insulin action. (2006) (34)
RalA controls glucose homeostasis by regulating glucose uptake in brown fat (2018) (34)
Insulin internalization and degradation in adipocytes from normal and type II diabetic subjects. (1986) (34)
Internalization and intracellular processing of insulin and insulin receptors in adipocytes. (1982) (34)
Annexin II is a thiazolidinedione-responsive gene involved in insulin-induced glucose transporter isoform 4 translocation in 3T3-L1 adipocytes. (2004) (34)
Role of intracellular energy in insulin's ability to activate 3-O-methylglucose transport by rat adipocytes. (1980) (34)
Characterization of a mutant human insulin species. (1980) (33)
Genetic Modulation of Lipid Profiles following Lifestyle Modification or Metformin Treatment: The Diabetes Prevention Program (2012) (33)
Intracellular signaling by a mutant human insulin receptor lacking the carboxyl-terminal tyrosine autophosphorylation sites. (1992) (33)
PPARG Regulates Gonadotropin-Releasing Hormone Signaling in LbetaT2 Cells In Vitro and Pituitary Gonadotroph Function In Vivo in Mice1 (2011) (33)
Mechanisms of fasting-induced increase in insulin binding to rat adipocytes. (1978) (33)
Restoration of Euglycemia After Duodenal Bypass Surgery Is Reliant on Central and Peripheral Inputs in Zucker fa/fa Rats (2013) (33)
Relationship between fasting plasma lipid levels and adipose tissue morphology. (1973) (33)
Phorbol ester-mediated protein kinase C interaction with wild-type and COOH-terminal truncated insulin receptors. (1991) (33)
Endocrine-metabolic relationships in patients with leprechaunism. (1982) (33)
Insulin binding to monocytes and total mononuclear leukocytes from normal and diabetic patients. (1976) (32)
Mechanisms of cellular insulin resistance in human pregnancy. (1994) (32)
Insulin binding, internalization, and receptor regulation in cultured human fibroblasts. (1981) (32)
Relationship Between Serum Glucose Level and the Metabolic Clearance Rate of Glucose in Non-insulin-dependent Diabetes Mellitus (1983) (32)
Do the Oral and Intravenous Glucose Tolerance Tests Provide Similar Diagnostic Information in Patients with Chemical Diabetes Mellitus? (1973) (32)
The osmotic shock-induced glucose transport pathway in 3T3-L1 adipocytes is mediated by gab-1 and requires Gab-1-associated phosphatidylinositol 3-kinase activity for full activation. (2000) (32)
Wnt Fans the Flames in Obesity (2010) (31)
Recycling of photoaffinity-labeled insulin receptors in rat adipocytes. Dissociation of insulin-receptor complexes is not required for receptor recycling. (1986) (31)
Insulin resistance and the pathogenesis of non-insulin dependent diabetes mellitus: cellular and molecular mechanisms. (1993) (31)
Regulation of epidermal growth factor receptor number and phosphorylation by fasting in rat liver. (1986) (31)
The effect of oral glucosamine sulfate on insulin sensitivity in human subjects. (2003) (31)
Food fallacies and blood sugar. (1983) (31)
The physiological significance of the glucose intolerance of aging. (1984) (31)
Parallel Decreases in the Expression of Receptors for Insulin and Insulin-like Growth Factor I in a Mutant Human Fibroblast Line (1983) (31)
A defect in cell-mediated immune function in insulin-resistant diabetic and obese subjects. (1980) (31)
Delayed Onset of Insulin Activation of the Insulin Receptor Kinase In Vivo in Human Skeletal Muscle (1994) (30)
Antiinsulin receptor antibodies in an insulin-dependent diabetic may arise as autoantiidiotypes. (1986) (30)
Lack of insulin resistance in fibroblasts from subjects with polycystic ovary syndrome. (1998) (30)
Degradation of Insulin Receptors in Rat Adipocytes (1983) (30)
Insulin resistance in noninsulin-dependent diabetes mellitus: impact of sulfonylurea agents in vivo and in vitro. (1983) (30)
Increased phosphorylation of ribosomal protein S6 following microinjection of insulin receptor-kinase into Xenopus oocytes (1986) (29)
Positive Reinforcing Mechanisms between GPR120 and PPARγ Modulate Insulin Sensitivity. (2020) (28)
Fructose, Xylitol, and Sorbitol (1980) (28)
Defect in Glucose Removal in Nonketotlc Diabetic Patients with Fasting Hyperglycemia (1978) (27)
Ability of circulating insulin to chronically regulate the cellular glucose transport system. (1978) (27)
Simultaneous Inhibition of Insulin and Somatomedin-C Binding to Cultured IM-9 Lymphocytes by Naturally Occurring Antireceptor Antibodies (1981) (26)
Tyrosine kinase-defective insulin receptors undergo insulin-induced microaggregation but do not concentrate in coated pits. (1991) (26)
Relationship Between Insulin Response During the Intravenous Glucose Tolerance Test, Rate of Fractional Glucose Removal and the Degree of Insulin Resistance in Normal Adults (1974) (26)
Day-Long Integrated Serum Insulin and C-Peptide Profiles in Patients With NIDDM: Correlation With Urinary C-Peptide Excretion (1988) (26)
Characterization of an insulin receptor mutant lacking the subunit processing site. (1990) (25)
Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin. (1998) (25)
Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function (2018) (25)
Separate intracellular pathways for insulin receptor recycling and insulin degradation in isolated rat adipocytes (1983) (25)
Tumor Necrosis Factor Receptor-1 Can Function through a Gαq/11-β-Arrestin-1 Signaling Complex* (2007) (25)
Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075 (2021) (25)
Kinetic relationships between insulin receptor binding and effects on glucose transport in isolated rat adipocytes. (1982) (24)
Dissociation of insulin resistance and decreased insulin receptor binding in Duchenne muscular dystrophy. (1985) (24)
Relationship between deactivation of insulin-stimulated glucose transport and insulin dissociation in isolated rat adipocytes. (1980) (24)
Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytes. (2003) (24)
Insulin resistance in non-insulin dependent (type II) and insulin dependent (type I) diabetes mellitus. (1985) (24)
Metabolism of photoaffinity-labeled insulin receptors by adipocytes. Role of internalization, degradation, and recycling. (1984) (24)
Interaction between insulin receptors and glucose transport: effect of prostaglandin E2. (1977) (23)
Amelioration of Glucose Intolerance by the Synthetic Androstene HE3286: Link to Inflammatory Pathways (2010) (23)
Tumor necrosis factor receptor-1 can function through a G alpha q/11-beta-arrestin-1 signaling complex. (2007) (23)
Evaluation of Insulin Resistance in Patients with Primary Hyperparathyroidism (1975) (23)
Cutaneous manifestations of leprechaunism. (1981) (22)
Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis (2018) (22)
Regulation of the insulin receptor by protein kinase C isoenzymes: preferential interaction with beta isoenzymes and interaction with the catalytic domain of betaII. (2004) (22)
Insulin receptors in isolated human adipocytes. Characterization by photoaffinity labeling and evidence for internalization and cellular processing. (1983) (22)
MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH. (2022) (21)
Synthesis of an organoinsulin molecule that can be activated by antibody catalysis (2001) (21)
Involvement of ErbB2 in the Signaling Pathway Leading to Cell Cycle Progression from a Truncated Epidermal Growth Factor Receptor Lacking the C-terminal Autophosphorylation Sites (*) (1996) (21)
Inhibition of PLC-γ1 activity converts nerve growth factor from an anti-mitogenic to a mitogenic signal in CHO cells (1999) (21)
Obese Neuronal PPAR&ggr; Knockout Mice Are Leptin Sensitive but Show Impaired Glucose Tolerance and Fertility (2016) (21)
Characterization of insulin-like growth factor (IGF) binding proteins and their role in modulating IGF-I action in BHK cells. (1992) (21)
Regulation of insulin receptors in cultured human fibroblasts. (1981) (21)
A New Way to Burn Fat (2006) (20)
ERRATUM: PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3 (2004) (20)
Tris (hydroxmethyl) aminomethane permits the expression of insulin-induced receptor loss in isolated rat adipocytes. (1981) (20)
Microbiota-Produced N-Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance (2019) (20)
Comparison of the effects of insulin and H2O2 on adipocyte glucose transport (1982) (20)
Fat-induced inflammation unchecked. (2010) (20)
Biochemical characterization and subcellular distribution of the glucose transporter from rat brain microvessels. (1987) (20)
The Effects of Oral Fructose, Sucrose, and Glucose in Subjects with Reactive Hypoglycemia (1982) (19)
Comparison of the effects of insulin and insulin-like agents on different aspects of adipocyte metabolism. (1979) (19)
Low pH accelerates dissociation of receptor-bound insulin. (1983) (19)
Insulin-responsive human adipocytes express two glucose transporter isoforms and target them to different vesicles. (1993) (18)
Effect of heterozygous PPARgamma deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding. (2003) (18)
4 Insulin resistance in non-insulindependent, type II diabetes mellitus (1982) (18)
Hormone resistance and hypersensitivity states (2002) (17)
Insulin Sensitivity of Isolated Perfused Rat Liver (1975) (17)
The effect of insulin concentration on retroendocytosis in isolated rat adipocytes. (1987) (17)
Hepatic insulin responsiveness in patients with endogenous hypertriglyceridaemia (1978) (17)
Insulin-induced beta-arrestin1 Ser-412 phosphorylation is a mechanism for desensitization of ERK activation by Galphai-coupled receptors. (2005) (17)
Mechanisms of Enhanced Transmembrane Signaling by an Insulin Receptor Lacking a Cytoplasmic -Subunit Domain (*) (1995) (17)
Role of Host GPR120 in Mediating Dietary Omega-3 Fatty Acid Inhibition of Prostate Cancer (2018) (17)
CX3CL1-Fc treatment prevents atherosclerosis in Ldlr KO mice (2018) (17)
Effects of prednisolone and dexamethasone in vivo and in vitro: Studies of insulin binding, deoxyglucose uptake and glucose oxidation in rat adipocytes (1981) (16)
Selective suppression of hepatic glucose output by human proinsulin in the dog. (1987) (16)
The Acute and Chronic Stimulatory Effects of Endothelin-1 on Glucose Transport Are Mediated by Distinct Pathways in 3T3-L1 Adipocytes* *This work was supported by NIH Grant DK-33651. (2000) (16)
Insulin resistance in non-insulin-dependent diabetes mellitus (1995) (16)
Human adipocyte glucose transport system. Biochemical and functional heterogeneity of hexose carriers. (1987) (16)
Mechanism of impaired metabolic signaling by a truncated human insulin receptor. Decreased activation of protein phosphatase 1 by insulin. (1993) (16)
Tyrosine kinase-defective insulin receptors undergo decreased endocytosis but do not affect internalization of normal endogenous insulin receptors. (1992) (16)
Ligand-independent GLUT4 translocation induced by guanosine 5'-O-(3-thiotriphosphate) involves tyrosine phosphorylation. (1998) (16)
3 The Genetics of Non-insulin-Dependent Diabetes Mellitus (1995) (16)
Further evidence for functional heterogeneity of adipocyte insulin receptors. (1979) (16)
The insulin receptor C-terminus is involved in regulation of the receptor kinase activity. (1993) (16)
Characterization of the Receptor Binding Properties of Monoiodoinsulin Isomers and the Identification of Different Insulin Receptor Specificities in Hepatic and Extrahepatic Tissues (1983) (15)
Intracellular insulin-receptor dissociation and segregation in a rat fibroblast cell line transfected with a human insulin receptor gene. (1988) (14)
Non-insulin-mediated glucose uptake predominates in postabsorptive dogs. (1987) (14)
Effect of a major histocompatibility complex class I peptide on insulin-like growth factor-I receptor internalization and biological signaling. (1993) (14)
The Insulin Receptor (1990) (14)
Adenosine modulates insulin activation of insulin receptor kinase in intact rat adipocytes. (1987) (14)
The Fractalkine / CX 3 CR 1 System Regulates b Cell Function and Insulin Secretion (14)
Length of acute exposure to insulin regulates the rate of deactivation of stimulated glucose transport in isolated rat adipocytes. (1983) (14)
Effects of general receptor for phosphoinositides 1 on insulin and insulin-like growth factor I-induced cytoskeletal rearrangement, glucose transporter-4 translocation, and deoxyribonucleic acid synthesis. (1998) (14)
Effect of obesity on susceptibility to fatty acid-induced peripheral tissue insulin resistance. (2003) (14)
Effect of intravenous glucose infusion on plasma insulin removal rate. (1974) (14)
Hypercholesterolemia and Atherosclerosis: Pathogenesis and Prevention (1987) (14)
Cancer-cell-secreted Extracellular Vesicles Suppress Insulin Secretion through miR-122 to Impair Systemic Glucose Homeostasis and Contribute to Tumour Growth (2022) (14)
Pertussis toxin-sensitive and -insensitive thrombin stimulation of Shc phosphorylation and mitogenesis are mediated through distinct pathways. (1999) (14)
Endocytotic uptake, processing, and retroendocytosis of human biosynthetic proinsulin by rat fibroblasts transfected with the human insulin receptor gene. (1988) (14)
Cycloheximide decreases glucose transporters in rat adipocyte plasma membranes without affecting insulin-stimulated glucose transport. (1988) (13)
Disassociation of the plasma insulin response from the blood glucose concentration during glucose infusions in normal dogs. (1973) (13)
The Metabolism of Insulin Receptors: Internalization, Degradation, and Recycling (1985) (13)
Diabetes mellitus : management and complications (1985) (13)
Obesity Modulates Intestinal Intraepithelial T Cell Persistence, CD103 and CCR9 Expression, and Outcome in Dextran Sulfate Sodium–Induced Colitis (2019) (13)
Metabolic Bone and Mineral Disorders (1988) (12)
Potential role for insulin and cycloheximide in regulating the intrinsic activity of glucose transporters in isolated rat adipocytes. (1993) (12)
Extracellular Vesicles and Their Emerging Roles as Cellular Messengers in Endocrinology: An Endocrine Society Scientific Statement. (2022) (12)
Functional and structural differences in human and rat-derived insulin receptors: characterization of the beta-subunit kinase activity. (1988) (12)
Post-binding events in insulin action (1985) (12)
Inducible Nitric Oxide Synthase Deficiency in Myeloid Cells Does Not Prevent Diet-Induced Insulin Resistance (2010) (12)
Hormonal and substrate responses to a standard meal in normal and hypertriglyceridemic subjects. (1981) (12)
Phosphatidylinositol 3-Kinase Is Required for Insulin-stimulated Tyrosine Phosphorylation of Shc in 3T3-L1 Adipocytes* (2002) (11)
Mechanism of SHIP-mediated inhibition of insulin- and platelet-derived growth factor-stimulated mitogen-activated protein kinase activity in 3T3-L1 adipocytes. (2005) (11)
Prolonged vs transient roles for early cell cycle signaling components (1998) (11)
Effects of General Receptor for Phosphoinositides 1 on Insulin and Insulin-Like Growth Factor I-Induced Cytoskeletal Rearrangement, Glucose Transporter-4 Translocation, and Deoxyribonucleic Acid Synthesis* * This work was supported by Grants J 01287-Med and J 1584-Med from the Erwin Schrödinger Sti (1998) (11)
Insulin inhibits nuclear phosphatase activity: requirement for the C-terminal domain of the insulin receptor. (1995) (11)
The acute and chronic stimulatory effects of endothelin-1 on glucose transport are mediated by distinct pathways in 3T3-L1 adipocytes. (2000) (11)
Cell Metabolism In Translation Omega 3 Fatty Acids and GPR 120 (2012) (11)
140-LB: NGM313, a Novel Activator of b-Klotho/FGFR1c, Improves Insulin Resistance and Reduces Hepatic Fat in Obese, Nondiabetic Subjects (2019) (11)
Relationship between negative cooperativity and insulin action. (1981) (11)
Cell signaling. A new way to burn fat. (2006) (11)
Inducible nitric oxide synthase deficiency in myeloid cells does not prevent diet-induced insulin resistance. (2010) (10)
Insulin-Receptor cDNA Sequence in NIDDM Patient Homozygous for Insulin-Receptor Gene RFLP (1991) (10)
Adipose tissue B 2 cells promote insulin resistance through leukotriene LTB 4 / LTB 4 R 1 signaling (2018) (10)
Insulin Binding, Biologic Activity, and Metabolism of Biosynthetic Human Insulin (1981) (10)
Metabolic requirements for deactivation of insulin-stimulated glucose transport in isolated rat adipocytes. (1981) (10)
Neuronal SIRT1 Regulates Metabolic and Reproductive Function and the Response to Caloric Restriction (2018) (9)
Insulin resistance in non-insulin-dependent, type II diabetes mellitus. (1982) (9)
Islet amyloid polypeptide (amylin) increases the renal excretion of calcium in the conscious dog (1994) (9)
Effect of a high carbohydrate diet on adipocyte glucose metabolism in spontaneously obese rats and insulin-deficient diabetic rats. (1980) (9)
Amylin release during oral glucose tolerance test. (1997) (8)
Insulin-stimulated glucose transport in cultured fibroblasts from normal and noninsulin-dependent (type II) diabetic human subjects. (1982) (8)
Effect of temperature on coupling of insulin receptors to stimulation of glucose transport in isolated rat adipocytes. (1983) (7)
Deletion of exon 21 of the insulin receptor eliminates tyrosine kinase activity but preserves mitogenic signaling. (1993) (7)
Transmembrane signaling by an insulin receptor lacking a cytoplasmic beta-subunit domain. (1993) (7)
The role of insulin resistance in the pathogenesis of diabetes mellitus. (1978) (7)
The US's changing competitiveness in the biomedical sciences. (2007) (7)
Chronic endothelin-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytes (2000) (6)
Obesity, Inflammation, and Insulin Resistance (2013) (6)
The ligand binding characteristics of a kinase-defective A/K1018 human insulin receptor expressed in Rat 1 fibroblasts. (1990) (6)
Kinetics of Biosynthetic Human Proinsulin Action in Isolated Rat Adipocytes (1986) (6)
Clinical, cellular, and physiologic effects of glyburide in non-insulin-dependent diabetes mellitus. (1985) (6)
Receptor-Mediated Internalization and Turnover (1990) (6)
Is a Rho GTPase Family Member That Can Mediate Insulin Signaling to Glucose Transport in 3 T 3L 1 Adipocytes * (2003) (6)
Characteristics of binding of a low affinity, noncooperative insulin [( LeuB25]insulin) to IM-9 lymphocytes. (1983) (5)
Chapter 40 – Type 2 Diabetes Mellitus: Etiology, Pathogenesis, and Natural History (2016) (5)
Fructose—Its Characteristics, Physiology, and Metabolism (1980) (5)
Effect of experimental hyperinsulinaemia on intracellular glucose metabolism of isolated adipocytes (1979) (5)
triglyceride levels in hypercholesterolemic subjects receiving ascorbic acid supplements1' 2, 3 (1975) (5)
Maintenance of metabolic homeostasis by Sestrin 2 and 3 (2013) (5)
Insulin and epidermal growth factor influence guanine nucleotide-releasing factor by distinct mechanisms. (1994) (5)
PS21 - 100. A PPAR -FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis (2012) (5)
Putting the brakes on FOXO1 in fat (2012) (5)
Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHβ gene expression by a SirT1-independent pathway in LβT2 gonadotrope cells. (2011) (5)
Hybrid formation between endogenous mouse and transfected human tyrosine kinase-deficient (A/K1018) insulin receptors leads to decreased insulin sensitivity in 3T3-L1 adipocytes. (1994) (5)
Protein Phosphatase-2 C as a Positive Regulator of Insulin Sensitivity through Direct Activation of Phosphatidylinositol 3-Kinase in 3 T 3L 1 Adipocytes * (2004) (5)
The Effect of Interventions to Prevent Type 2 Diabetes on the Development of Diabetic Retinopathy: The DPP/DPPOS Experience (2022) (5)
EBP regulates macrophage activation and systemic metabolism (2014) (4)
Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer (2015) (4)
A truncated human insulin receptor missing the COOH-terminal 365 amino acid residues does not undergo insulin-mediated receptor migration or aggregation. (1993) (4)
N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model. (2018) (3)
Insulin binding to erythrocytes incubated in vitro at physiological temperature. (1983) (3)
The 2018 World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) score and diabetes risk in the Diabetes Prevention Program Outcomes Study (DPPOS) (2022) (3)
The preparation and characterization of mono-iodinated photoreactive analogs of insulin. (1985) (3)
Internalization and degradation of a low affinity insulin ([LeuB24]insulin) by rat adipocytes (1982) (3)
Post-binding events in insulin action. (1985) (3)
The genetics of non-insulin-dependent diabetes mellitus. (1995) (3)
Mechanisms of insulin degradation by isolated rat adipocytes (1982) (3)
Preparation of NϵB28-monoazidobenzoyl insulin-like growth factor I and photoaffinity labeling of insulin-like growth factor I receptor (1993) (2)
A Novel Pathway for Regulation of Insulin Secretion by Fractalkine and CX3CR1 System (LB772) (2014) (2)
Mechanisms of Insulin Resistance in Obese and Type II Diabetic Subjects (1989) (2)
Deletion of the insulin receptor beta-subunit acidic domain results in enhanced metabolic signaling. (1993) (2)
Hepatic ultrastructure in leprechaunism (1982) (2)
Photolabeling of the adipocyte hexose carrier with an aryl azide derivative of maltose (1987) (2)
Erratum: Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-α (Diabetes (2002) 51 (3176-3188)) (2003) (2)
Diabetes, Vol. 34 (3), 1985 The effect of insulin treatment on in sulin secretion and insulin action in Type II diabetes mellitus (1985) (2)
Synthesis and evaluation of photolabile insulin prodrugs. (2005) (2)
Does glucagon play a role in the insulin resistance of patients with adult non-ketotic diabetes? (1977) (1)
Use of thiazolidinediones to prevent or delay the onset non-insulin dependent diabetes. (1994) (1)
Properties of a Mutant Insulin Species Causing Human Diabetes (1980) (1)
Three authors were omitted from the article. The corrected author and affiliation lines are shown below. (2013) (1)
Recent advances in insulin action and its disorders : proceedings of the International Symposium on Insulin Action and Its Disorders, Shiga, 16 May 1990 (1991) (0)
Mechanism of activation of guanine nucleotide exchange factor by insulin (1995) (0)
A non-invasive method to measure splanchnic glucose uptake following oral glucose administration (1994) (0)
Eating macrophages for a healthy anti-NASH meal. (2023) (0)
Inflammation and Insulin Resistance (2012) (0)
Accelerated fasting in leprechaunism. (1980) (0)
Figure 4, [Pathways of fatty acid disposal...]. (2013) (0)
The 2011–2016 Transdisciplinary Research on Energetics and Cancer (TREC) Initiative: Rationale and Design (2013) (0)
The mechanism of cellular insulin resistance at the glucose-transport level in noninsulin-dependent diabetes mellitus (1988) (0)
The use of thiazolidinediones to prevent or delay the onset of NIDDM (1994) (0)
Effect of brain specific deletion of PPARγ on puberty onset, hypothalamic gene expression and diet induced obesity (DIO) in C57BL/6 mice (2012) (0)
O-36: A possible role for phospholipase Cγ in insulin action? (2009) (0)
Correction: GPR105 Ablation Prevents Inflammation and Improves Insulin Sensitivity in Mice with Diet-Induced Obesity (2013) (0)
TITLE: Role of Inflammation and Insulin Resistance in Mouse Models of Breast Cancer (2013) (0)
NUCLEAR RECEPTORS & DISEASE (2010) (0)
Extracellular Vesicles and Their Emerging Roles as Cellular Messengers in Endocrinology: An Endocrine Society Scientific Statement. (2022) (0)
2-OR: Exosomes from Adipose Tissue Macrophages Can Mediate Insulin-Sensitizing Effects of Rosiglitazone (2022) (0)
Effect of caloric restriction on the expression of the Sirtuin Proteins (2012) (0)
Intestinal FXR: A New Therapeutic Target for Nonalcoholic Fatty Liver Disease (2015) (0)
Mechanisms Mediating Obesity-Induced Inflammation and Insulin Resistance (2011) (0)
Diet-Induced Obesity Improves Insulin Sensitivity in Mice with GPR105 Ablation Prevents Inflammation and (2012) (0)
A truncated human insulin receptor missing the COOH-terminal 365 amino acid residues does not undergo insulin-mediated receptor migration or aggregation (1993) (0)
Insulin receptor tyrosine kinase activity is reduced in type-2 (non-insulin-dependent) diabetes but not in obesity (1987) (0)
Cdc 42 is a Rho GTPase Family Member Which can Mediate Insulin Signaling to Glucose Transport in 3 T 3L 1 Adipocytes (2003) (0)
Rosiglitizone treatment does not improve insulin sensitivity in mice with whole body CAP gene deletion (2006) (0)
O-20: Disruption of the interaction between the insulin receptor and IRS-1 does not impair insulin stimulated GLUT4 translocation (2009) (0)
RESEARCH OPPORTUNITIES FOR SPECIFIC DISEASES AND DISORDERS Prospects for Research in Diabetes Mellitus (2001) (0)
Leukocyte GPR120 differentiates hypolipidemic vs. anti‐inflammatory effects of long chain n‐3 and n‐6 polyunsaturated fatty acids in inducing atherosclroprotection in LDLrKo mice (1146.7) (2014) (0)
A Tribute to Robert Roy Henry—The Classic “Academic Triple Threat”: Accomplished Researcher, Inspiring Teacher, and Compassionate Clinician (2020) (0)
of insulin receptors in rat adipocyt (down-regulation/receptor degradation/chloroquine) (2016) (0)
Examination of the reproductive effects of SirT1 expression in neurons (2012) (0)
Abstract A123: Omega-3 fatty acids reduce mammary tumor growth in a mouse model of postmenopausal breast cancer (2013) (0)
Cellular insulin resistance decreases osmotic shock-induced glucose transport in 3T3-L1 adipocytes (2000) (0)
Annexin II Is Involved in Insulin-Induced GLUT4 Translocation in 3T3-L1 Adipocytes (2002) (0)
Moderate Ethanol Ingestion and Plasma Triglyceride Levels (2020) (0)
Perspectives in Diabetes The Insulin Receptor A Multifunctional Protein (2006) (0)
Supplemental Information Maintenance of Metabolic Homeostasis by Sestrin 2 and Sestrin 3 (2012) (0)
Guest Commentaries (2012) (0)
Knockdown of ANT2 reduces adipocyte hypoxia and improves insulin resistance in obesity (2018) (0)
Phorbol ester effects on the insulin receptor are not mediated by carboxyl terminal serin threonine phosphorylation (1990) (0)
Carbohydrate Homeostasis in Children With Leprechaunism. (1979) (0)
Protection against hepatic steatosis and systemic insulin resistance by liver‐specific depletion of p70 S6 kinase (2012) (0)
Abstract 308: Rgs2 Is An Endogenous Inhibitor Of Insulin Signaling (2008) (0)
Inverse Regulation of In fl ammation and Mitochondrial Function in Adipose Tissue De fi nes Extreme Insulin Sensitivity in Morbidly Obese Patients (2013) (0)
Use of thiazolidinediones for preventing or delaying the onset of non-insulin dependent diabetes mellitus (NIDDM) (1994) (0)
Weighing in on the lean genes. (1995) (0)
Preparation of N epsilon B28-monoazidobenzoyl insulin-like growth factor I and photoaffinity labeling of insulin-like growth factor I receptor. (1993) (0)
Sex Difference in the Kinetics of Triglyceride Metabolism in Normal and Hypertriglyceridaemic Human Subjects (1974) (0)
Erratum: GPR105 ablation prevents inflammation and improves insulin sensitivity in mice with diet-induced obesity (The Journal of Immunology (2012) 189 (1992-1999)) (2013) (0)
Insulin Action and Insulin Resistance in Noninsulin-Dependent Diabetes Mellitus (1997) (0)
Status of Research Funded by the American Diabetes Association — Year 4 I n 1998 (2003) (0)
Semisynthesis andbiological activity ofporcine (LeuB24)insulin and (LeuB25)insulin (solid-phase peptide synthesis/desoctapeptide insulin/insulin analog/insulin antagonist/rat adipocytes) (1980) (0)
Role of Inflammation and Insulin Resistance in Mouse Models of Breast Cancer (2012) (0)
Correlation of metabolic parameters with high and low affinity insulin receptor binding in leprechaunism (L) (1981) (0)
ffects of Troglitazone on Blood Concentrations of Plasminogen Activator Inhibitor 1 in Patients Wi t h Type 2 Diabetes and in Lean and Obese Normal (2000) (0)
UPDATE of the Journals (1982) (0)

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