Jerry Pelletier
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Jerry Pelletierchemistry Degrees
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Chemical Engineering
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Chemistry
Jerry Pelletier's Degrees
- PhD Chemistry University of California, Berkeley
- Masters Chemical Engineering Stanford University
- Bachelors Chemical Engineering Stanford University
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(Suggest an Edit or Addition)Jerry Pelletier's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- WT-1 is required for early kidney development (1993) (1963)
- Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA (1988) (1851)
- Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus (1990) (1813)
- Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy (2004) (979)
- Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome (1991) (914)
- The candidate Wilms' tumour gene is involved in genitourinary development (1990) (874)
- Short RNAs repress translation after initiation in mammalian cells. (2006) (840)
- Statistical practice in high-throughput screening data analysis (2006) (679)
- Alternative splicing and genomic structure of the Wilms tumor gene WT1. (1991) (604)
- Targeting the translation machinery in cancer (2015) (595)
- An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor (1990) (586)
- Insertion mutagenesis to increase secondary structure within the 5′ noncoding region of a eukaryotic mRNA reduces translational efficiency (1985) (532)
- RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer (2014) (471)
- The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo. (2015) (457)
- Dissecting eIF4E action in tumorigenesis. (2007) (455)
- WT1 mutations contribute to abnormal genital system development and hereditary Wilms' tumour (1991) (443)
- Expression of the Wilms' tumor gene WT1 in the murine urogenital system. (1991) (443)
- eIF2α Phosphorylation Bidirectionally Regulates the Switch from Short- to Long-Term Synaptic Plasticity and Memory (2007) (406)
- Target identification using drug affinity responsive target stability (DARTS) (2009) (383)
- Target identification using drug affinity responsive target stability (DARTS). (2009) (348)
- Nuclear localization of the protein encoded by the Wilms' tumor gene WT1 in embryonic and adult tissues. (1993) (341)
- The complete genomes and proteomes of 27 Staphylococcus aureus bacteriophages. (2005) (339)
- Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A (2006) (327)
- Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation. (2006) (304)
- Anaplastic Wilms' tumour, a subtype displaying poor prognosis, harbours p53 gene mutations (1994) (296)
- Cap-independent translation of poliovirus mRNA is conferred by sequence elements within the 5' noncoding region (1988) (294)
- Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model. (2008) (290)
- Targeting the eIF4F translation initiation complex: a critical nexus for cancer development. (2015) (265)
- A cellular protein that binds to the 5'-noncoding region of poliovirus RNA: implications for internal translation initiation. (1989) (263)
- mTORC1 promotes survival through translational control of Mcl-1 (2008) (259)
- Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development (1991) (258)
- Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol (2009) (254)
- Antimicrobial drug discovery through bacteriophage genomics (2004) (214)
- Structural conservation of druggable hot spots in protein–protein interfaces (2011) (208)
- Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation. (2005) (205)
- Absence of p53 gene mutations in primary neuroblastomas. (1993) (204)
- Germline intronic and exonic mutations in the Wilms' tumour gene (WT1) affecting urogenital development (1992) (198)
- Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing (2015) (191)
- Structural and functional analysis of the ribosome landing pad of poliovirus type 2: in vivo translation studies (1991) (184)
- Sequence and structural requirements for high-affinity DNA binding by the WT1 gene product (1995) (182)
- Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases. (2011) (179)
- High-Throughput Screening of G Protein-Coupled Receptor Antagonists Using a Bioluminescence Resonance Energy Transfer 1-Based β-Arrestin2 Recruitment Assay (2005) (176)
- nanoCAGE reveals 5′ UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs (2016) (171)
- Uncoupling stress granule assembly and translation initiation inhibition. (2009) (169)
- c-Myc and eIF4F are components of a feedforward loop that links transcription and translation. (2008) (160)
- Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F (2010) (153)
- Evidence for a familial Wilms' tumour gene (FWT1) on chromosome 17q12–q21 (1996) (150)
- The Wilms’ Tumor Suppressor Gene (wt1) Product Regulates Dax-1 Gene Expression during Gonadal Differentiation (1999) (149)
- A Non-AUG Translational Initiation Event Generates Novel WT1 Isoforms (*) (1996) (148)
- Comparative Genomic Analysis of 18 Pseudomonas aeruginosa Bacteriophages (2006) (147)
- Caliciviruses Differ in Their Functional Requirements for eIF4F Components* (2006) (146)
- The Organizing Principles of Eukaryotic Ribosome Recruitment. (2019) (145)
- Microdeletion of target sites for insulator protein CTCF in a chromosome 11p15 imprinting center in Beckwith-Wiedemann syndrome and Wilms' tumor. (2005) (143)
- RNA-mediated sequestration of the RNA helicase eIF4A by Pateamine A inhibits translation initiation. (2006) (138)
- Clonal expansion and attenuated apoptosis in Wilms' tumors are associated with p53 gene mutations. (1995) (135)
- Inhibitors of protein synthesis identified by a high throughput multiplexed translation screen. (2004) (133)
- The paired-box transcription factor, PAX2, positively modulates expression of the Wilms' tumor suppressor gene (WT1). (1996) (130)
- Fine structure analysis of the WT1 gene in sporadic Wilms tumors. (1994) (129)
- A tumour suppressor network relying on the polyamine–hypusine axis (2012) (128)
- Modulation of RNA Condensation by the DEAD-Box Protein eIF4A (2019) (127)
- Repurposing CRISPR/Cas9 for in situ functional assays (2013) (127)
- Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability. (2006) (126)
- Internal binding of eucaryotic ribosomes on poliovirus RNA: translation in HeLa cell extracts (1989) (126)
- MicroRNAs trigger dissociation of eIF4AI and eIF4AII from target mRNAs in humans. (2014) (126)
- Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression. (2000) (124)
- Characterization of hMTr1, a Human Cap1 2′-O-Ribose Methyltransferase* (2010) (121)
- Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs. (2008) (118)
- Mutational analysis of upstream AUG codons of poliovirus RNA (1988) (117)
- Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas (2010) (114)
- Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo. (2006) (113)
- Tumorigenic activity and therapeutic inhibition of Rheb GTPase. (2008) (112)
- Selective Pharmacological Targeting of a DEAD Box RNA Helicase (2008) (110)
- Translation in mammalian cells of a gene linked to the poliovirus 5' noncoding region. (1988) (109)
- Antagonism of WT1 activity by protein self-association. (1995) (107)
- Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma (2011) (106)
- New Ways of Initiating Translation in Eukaryotes? (2001) (104)
- The biology of DHX9 and its potential as a therapeutic target (2016) (103)
- Repression of the retinoic acid receptor-alpha gene by the Wilms' tumor suppressor gene product, wt1. (1995) (102)
- Inhibition of translation by RNA-small molecule interactions. (2002) (102)
- Protospacer Adjacent Motif (PAM)-Distal Sequences Engage CRISPR Cas9 DNA Target Cleavage (2014) (101)
- The murine Sim-2 gene product inhibits transcription by active repression and functional interference (1997) (98)
- Overlapping RNA and DNA binding domains of the wt1 tumor suppressor gene product. (1998) (98)
- A mammalian translation initiation factor can substitute for its yeast homologue in vivo. (1989) (98)
- Evidence for a functionally relevant rocaglamide binding site on the eIF4A-RNA complex. (2013) (96)
- Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone. (1997) (95)
- Translation Initiation Factors: Reprogramming Protein Synthesis in Cancer. (2016) (94)
- Enantioselective synthesis of the complex rocaglate (-)-silvestrol. (2007) (93)
- Altering Chemosensitivity by Modulating Translation Elongation (2009) (89)
- Exploring the Impact of Single-Nucleotide Polymorphisms on Translation (2018) (87)
- A cellular response linking eIF4AI activity to eIF4AII transcription. (2012) (87)
- An efficient strategy to isolate full-length cDNAs based on an mRNA cap retention procedure (CAPture) (1995) (86)
- Differential efficiencies of in vitro translation of mouse c-myc transcripts differing in the 5' untranslated region. (1985) (86)
- Photochemical cross-linking of cap binding proteins to eucaryotic mRNAs: effect of mRNA 5' secondary structure (1985) (85)
- Blocking eIF4E-eIF4G Interaction as a Strategy To Impair Coronavirus Replication (2011) (85)
- The involvement of mRNA secondary structure in protein synthesis. (1987) (84)
- A Novel Function of eIF2α Kinases as Inducers of the Phosphoinositide-3 Kinase Signaling Pathway (2007) (83)
- Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing (2010) (83)
- Targeting synthetic lethal interactions between Myc and the eIF4F complex impedes tumorigenesis. (2012) (82)
- PAX2 Activates WNT4 Expression during Mammalian Kidney Development* (2006) (81)
- A lysine substitution in the ATP-binding site of eucaryotic initiation factor 4A abrogates nucleotide-binding activity (1989) (79)
- Synthesis of rocaglamide hydroxamates and related compounds as eukaryotic translation inhibitors: synthetic and biological studies. (2012) (79)
- eIF4F suppression in breast cancer affects maintenance and progression (2013) (78)
- Analysis of the 11p13 Wilms' tumor suppressor gene (WT1) in ovarian tumors. (1993) (76)
- CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A (2016) (73)
- Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2′-O methylations (2017) (73)
- PAX8‐mediated activation of the wt1 tumor suppressor gene. (1996) (71)
- Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain. (1998) (71)
- Molecular genetics of chromosome translocations involving EWS and related family members. (1999) (70)
- WT1 mutations associated with incomplete Denys-Drash syndrome define a domain predicted to behave in a dominant-negative fashion. (1994) (70)
- Translational efficiency of poliovirus mRNA: mapping inhibitory cis-acting elements within the 5' noncoding region (1988) (68)
- The Herpes Simplex Virus 1 vhs Protein Enhances Translation of Viral True Late mRNAs and Virus Production in a Cell Type-Dependent Manner (2011) (68)
- A modular and flexible ESC-based mouse model of pancreatic cancer (2014) (68)
- The desmoplastic small round cell tumor t(11;22) translocation produces EWS/WT1 isoforms with differing oncogenic properties (1998) (66)
- The effect of poliovirus proteinase 2Apro expression on cellular metabolism. Inhibition of DNA replication, RNA polymerase II transcription, and translation. (1991) (66)
- Full-length cDNAs: more than just reaching the ends. (2001) (65)
- CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary (2019) (65)
- Targeting Translation Dependence in Cancer (2011) (64)
- Eukaryotic protein synthesis inhibitors identified by comparison of cytotoxicity profiles. (2004) (63)
- Identification of a new polypeptide coded by reovirus gene S1 (1985) (63)
- Translation of nonSTOP mRNA is repressed post‐initiation in mammalian cells (2007) (62)
- Identification of nuclear localization signals within the zinc fingers of the WT1 tumor suppressor gene product (1996) (62)
- NAP-2: histone chaperone function and phosphorylation state through the cell cycle. (2000) (62)
- Targeting the eIF4A RNA helicase as an anti-neoplastic approach. (2015) (62)
- Different transcriptional properties of mSim‐1 and mSim‐2 (2000) (62)
- Conditional Reverse Tet-Transactivator Mouse Strains for the Efficient Induction of TRE-Regulated Transgenes in Mice (2014) (61)
- c-Myc and eIF4F constitute a feedforward loop that regulates cell growth: implications for anticancer therapy. (2009) (61)
- The Yeast Split-Ubiquitin Membrane Protein Two-Hybrid Screen Identifies BAP31 as a Regulator of the Turnover of Endoplasmic Reticulum-Associated Protein Tyrosine Phosphatase-Like B (2004) (60)
- Constitutional WT1 mutations in Wilms' tumor patients. (1998) (59)
- Genomic organization of the canine p53 gene and its mutational status in canine mammary neoplasia (1998) (58)
- Emerging therapeutics targeting mRNA translation. (2012) (58)
- 2'-Fluoro-4'-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity. (2007) (58)
- Synergistic effect of inhibiting translation initiation in combination with cytotoxic agents in acute myelogenous leukemia cells. (2010) (58)
- A new antimalarial quassinoid from Simaba orinocensis. (2004) (57)
- The translation inhibitor pateamine A prevents cachexia-induced muscle wasting in mice (2012) (57)
- Assessment of the total number of human transcription units. (2001) (56)
- Modifying chemotherapy response by targeted inhibition of eukaryotic initiation factor 4A (2013) (56)
- Hepatitis C virus-related internal ribosome entry sites are found in multiple genera of the family Picornaviridae. (2006) (55)
- Triaminotriazine DNA helicase inhibitors with antibacterial activity. (2006) (52)
- A dominant mutation in the Wilms tumor gene WT1 cooperates with the viral oncogene E1A in transformation of primary kidney cells. (1992) (51)
- Biomimetic photocycloaddition of 3-hydroxyflavones: synthesis and evaluation of rocaglate derivatives as inhibitors of eukaryotic translation. (2010) (50)
- Cap-dependent eukaryotic initiation factor-mRNA interactions probed by cross-linking. (2008) (50)
- The antidepressant sertraline inhibits translation initiation by curtailing mammalian target of rapamycin signaling. (2010) (48)
- Structure-activity relationships of quassinoids for eukaryotic protein synthesis. (2005) (48)
- Multiple mRNAs encode the murine translation initiation factor eIF-4E. (1991) (47)
- Translation initiation factor eIF4F modifies the dexamethasone response in multiple myeloma (2014) (47)
- Persistent Transcription- and Translation-Dependent Long-Term Potentiation Induced by mGluR1 in Hippocampal Interneurons (2009) (46)
- An upstream open reading frame impedes translation of the huntingtin gene. (2002) (46)
- Functional characterization of WT1 binding sites within the human vitamin D receptor gene promoter. (2001) (46)
- Synthesis of the antiproliferative agent hippuristanol and its analogues via Suárez cyclizations and Hg(II)-catalyzed spiroketalizations. (2011) (45)
- eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma (2019) (45)
- Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance (2016) (45)
- Insights into the physiological role of WT1 from studies of genetically modified mice. (2004) (45)
- A novel function of eIF2alpha kinases as inducers of the phosphoinositide-3 kinase signaling pathway. (2007) (44)
- Chlorolissoclimides: new inhibitors of eukaryotic protein synthesis. (2006) (44)
- 2′,3′‐Cyclic nucleotide 3′‐phosphodiesterase: A novel RNA‐binding protein that inhibits protein synthesis (2009) (43)
- Translation initiation: a critical signalling node in cancer (2009) (43)
- Ribavirin is not a functional mimic of the 7-methyl guanosine mRNA cap. (2005) (43)
- Dissecting eIF 4 E action in tumorigenesis Material Supplemental (2007) (43)
- 2'-O-methylation of the mRNA cap protects RNAs from decapping and degradation by DXO (2018) (42)
- Inhibitors of translation initiation as cancer therapeutics. (2009) (42)
- A harmine‐derived beta‐carboline displays anti‐cancer effects in vitro by targeting protein synthesis (2017) (42)
- The DNA binding domains of the WT1 tumor suppressor gene product and chimeric EWS/WT1 oncoprotein are functionally distinct (1998) (41)
- Single-molecule kinetics of the eukaryotic initiation factor 4AI upon RNA unwinding. (2014) (41)
- Hippuristanol - A potent steroid inhibitor of eukaryotic initiation factor 4A (2016) (41)
- PAM multiplicity marks genomic target sites as inhibitory to CRISPR-Cas9 editing (2015) (41)
- A new class of small molecule RNA polymerase inhibitors with activity against rifampicin-resistant Staphylococcus aureus. (2006) (41)
- WT1 is a modifier of the Pax2 mutant phenotype: cooperation and interaction between WT1 and Pax2 (2003) (40)
- Efficient synthetic approach to potent antiproliferative agent hippuristanol via Hg(II)-catalyzed spiroketalization. (2010) (40)
- Experimental Design and Statistical Methods for Improved Hit Detection in High-Throughput Screening (2010) (40)
- Tumor Cell Survival Dependence on the DHX9 DExH-Box Helicase (2016) (39)
- The eukaryotic initiation factor eIF4H facilitates loop-binding, repetitive RNA unwinding by the eIF4A DEAD-box helicase (2012) (39)
- Minor C-geranylated flavanones from Paulownia tomentosa fruits with MRSA antibacterial activity. (2013) (39)
- Microdeletion and IGF2 loss of imprinting in a cascade causing Beckwith-Wiedemann syndrome with Wilms' tumor (2005) (39)
- Perturbations of RNA helicases in cancer (2013) (39)
- Characterization of msim, a murine homologue of the Drosophila sim transcription factor. (1996) (39)
- Targeting protein synthesis in a Myc/mTOR-driven model of anorexia-cachexia syndrome delays its onset and prolongs survival. (2012) (38)
- Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm (2015) (37)
- Silibinin inhibits translation initiation: implications for anticancer therapy (2009) (37)
- The human steroidogenic acute regulatory (StAR) gene is expressed in the urogenital system and encodes a mitochondrial polypeptide. (1995) (37)
- Activation of the wt1 Wilms' tumor suppressor gene by NF-κB (1998) (37)
- Nucleotide binding and nucleotide hydrolysis properties of the ABC transporter MRP6 (ABCC6). (2002) (36)
- Translation initiation factor-dependent extracts from Saccharomyces cerevisiae. (1990) (36)
- eIF4AII is dispensable for miRNA-mediated gene silencing (2015) (35)
- Beyond molecular tumor heterogeneity: protein synthesis takes control (2018) (35)
- Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F (2020) (35)
- Poliovirus translation: A paradigm for a novel initiation mechanism (1989) (34)
- Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer. (2016) (34)
- Familial Wilms' tumor associated with a WT1 zinc finger mutation. (1996) (34)
- Phenylpyrrolocytosine as an unobtrusive base modification for monitoring activity and cellular trafficking of siRNA. (2011) (33)
- RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an Eμ-myc/Bcl-2 mouse model. (2013) (33)
- Suppression of the DHX9 Helicase Induces Premature Senescence in Human Diploid Fibroblasts in a p53-dependent Manner* (2014) (33)
- Modification of EWS/WT1 functional properties by phosphorylation. (1999) (33)
- Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors. (2019) (33)
- Inhibition of Wilms Tumor 1 Transactivation by Bone Marrow Zinc Finger 2, a Novel Transcriptional Repressor* (2002) (33)
- A CRISPR/Cas9 Functional Screen Identifies Rare Tumor Suppressors (2016) (33)
- Mitochondrion-dependent N-terminal Processing of Outer Membrane Mcl-1 Protein Removes an Essential Mule/Lasu1 Protein-binding Site* (2011) (32)
- Internal Translation Initiation Mediated by the Angiogenic Factor Tie2* (2005) (32)
- Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides. (2017) (32)
- Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism (2019) (32)
- Blocking UV‐Induced eIF2α Phosphorylation with Small Molecule Inhibitors of GCN2 (2009) (32)
- O-GlcNAcylation of core components of the translation initiation machinery regulates protein synthesis (2019) (32)
- Eukaryotic initiation factor 4F: a vulnerability of tumor cells. (2012) (31)
- Requirements for eIF4A and eIF2 during translation of Sindbis virus subgenomic mRNA in vertebrate and invertebrate host cells (2013) (31)
- Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition. (2009) (31)
- Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation. (2013) (31)
- Role of Eukaryotic Messenger RNA Cap-Binding Protein in Regulation of Translation (1987) (27)
- The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response. (2009) (27)
- Activation of the WT1 tumor suppressor gene promoter by Pea3 (2004) (26)
- Functional characterization of ORCTL2 ‐ an organic cation transporter expressed in the renal proximal tubules (1998) (26)
- Modulation of EWS/WT1 activity by the v‐Src protein tyrosine kinase (2000) (26)
- Isoflavones and Rotenoids from the Leaves of Millettia oblata ssp. teitensis. (2017) (25)
- General and Target-Specific DExD/H RNA Helicases in Eukaryotic Translation Initiation (2020) (25)
- Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition. (2016) (25)
- Tumor progression and metastasis: role of translational deregulation. (2012) (24)
- Polyoxygenated Cyclohexenes and Other Constituents of Cleistochlamys kirkii Leaves. (2017) (24)
- her-2 upstream open reading frame effects on the use of downstream initiation codons. (2006) (24)
- Therapeutic Opportunities in Eukaryotic Translation. (2018) (24)
- Stimulation of hTAFII68 (NTD)‐mediated transactivation by v‐Src (2004) (23)
- Competition of bacteriophage polypeptides with native replicase proteins for binding to the DNA sliding clamp reveals a novel mechanism for DNA replication arrest in Staphylococcus aureus (2006) (23)
- Activation of the wt1 Wilms' tumor suppressor gene by NF-kappaB. (1998) (23)
- Cycloheximide and congeners as inhibitors of eukaryotic protein synthesis from endophytic actinomycetes Streptomyces sps. YIM56132 and YIM56141 (2011) (23)
- Selective targeting of the DEAD-box RNA helicase eukaryotic initiation factor (eIF) 4A by natural products. (2019) (22)
- Increased in vitro and in vivo sensitivity of BRCA2-associated pancreatic cancer to the poly(ADP-ribose) polymerase-1/2 inhibitor BMN 673. (2015) (22)
- 2′-Fluoro-4′-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity (2007) (22)
- Identification of compounds that decrease the fidelity of start codon recognition by the eukaryotic translational machinery. (2011) (22)
- Amygdala inhibitory neurons as loci for translation in emotional memories (2020) (22)
- Obatoclax is a direct and potent antagonist of membrane-restricted Mcl-1 and is synthetic lethal with treatment that induces Bim (2015) (21)
- Inhibitory properties of nucleic acid‐binding ligands on protein synthesis (2005) (21)
- Inhibition of Transcription in Staphylococcus aureus by a Primary Sigma Factor-Binding Polypeptide from Phage G1 (2009) (21)
- Rocaglates as dual-targeting agents for experimental cerebral malaria (2018) (21)
- Chemical Synthesis Enables Structural Reengineering of Aglaroxin C Leading to Inhibition Bias for Hepatitis C Viral Infection. (2018) (21)
- Identifying small molecule inhibitors of eukaryotic translation initiation. (2007) (21)
- Desmocollin 1 is abundantly expressed in atherosclerosis and impairs high-density lipoprotein biogenesis (2018) (21)
- Intercepted Retro-Nazarov Reaction: Syntheses of Amidino-Rocaglate Derivatives and Their Biological Evaluation as eIF4A Inhibitors. (2019) (20)
- Forced engagement of a RNA/protein complex by a chemical inducer of dimerization to modulate gene expression (2002) (20)
- Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response (2017) (20)
- Alternative splicing and genomic structure of the Wilms tumor gene WT 1 ( alternative splicing / genomic structure (20)
- The von Hippel-Lindau Protein pVHL Inhibits Ribosome Biogenesis and Protein Synthesis* (2013) (19)
- Inhibitors of translation targeting eukaryotic translation initiation factor 4A. (2012) (19)
- Gene expression studies for the analysis of domoic acid production in the marine diatom Pseudo-nitzschia multiseries (2013) (19)
- Adapting CRISPR/Cas9 for functional genomics screens. (2014) (19)
- Nuclear assortment of eIF4E coincides with shut-off of host protein synthesis upon poliovirus infection. (2010) (19)
- eIF4A Inhibitors Suppress Cell-Cycle Feedback Response and Acquired Resistance to CDK4/6 Inhibition in Cancer (2019) (18)
- The human insulin mRNA is partly translated via a cap- and eIF4A-independent mechanism. (2011) (18)
- Inhibition of translation by cytotrienin A--a member of the ansamycin family. (2010) (17)
- Drug-induced Stress Granule Formation Protects Sensory Hair Cells in Mouse Cochlear Explants During Ototoxicity (2019) (17)
- 30 Therapeutic Opportunities in Translation (2007) (17)
- Translation Inhibition by Rocaglates Is Independent of eIF4E Phosphorylation Status (2015) (17)
- A chemical genetic screen for mTOR pathway inhibitors based on 4E-BP-dependent nuclear accumulation of eIF4E. (2009) (16)
- Differential action of pateamine A on translation of genomic and subgenomic mRNAs from Sindbis virus. (2015) (16)
- Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation (2019) (16)
- A comparative study of small molecules targeting eIF4A (2020) (16)
- Downregulation of PTP1B and TC-PTP phosphatases potentiate dendritic cell-based immunotherapy through IL-12/IFNγ signaling (2017) (15)
- Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5′ leader regions (2020) (15)
- Wilms' tumor: a paradigm for insights into development and cancer. (1995) (15)
- Assignment of two of the translation initiation factor-4E (EIF4EL1 and EIF4EL2) genes to human chromosomes 4 and 20. (1991) (15)
- Internal translation initiation from HIV-1 transcripts is conferred by a common RNA structure (2014) (15)
- Inducible Genome Editing with Conditional CRISPR/Cas9 Mice (2018) (15)
- RNA-tethering assay and eIF4G:eIF4A obligate dimer design uncovers multiple eIF4F functional complexes (2020) (14)
- Inhibition of protein synthesis by aminoglycoside-arginine conjugates. (2002) (14)
- High-throughput assays probing protein-RNA interactions of eukaryotic translation initiation factors. (2009) (14)
- The multifaceted eukaryotic cap structure (2020) (14)
- A Novel Function of eIF 2 Kinases as Inducers of the Phosphoinositide-3 Kinase Signaling Pathway (2007) (13)
- Kaiso mediates human ICR1 methylation maintenance and H19 transcriptional fine regulation (2016) (13)
- 5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells. (2016) (13)
- Synthesis of the antiproliferative agent hippuristanol and its analogues from hydrocortisone via Hg(II)-catalyzed spiroketalization: structure-activity relationship. (2014) (13)
- Germline WT1 mutations in Wilms' tumor patients: preliminary results. (1996) (13)
- The Tie2 5′ untranslated region is inhibitory to 5′ end‐mediated translation initiation (2006) (13)
- Functional mimicry revealed by the crystal structure of an eIF4A:RNA complex bound to the interfacial inhibitor, desmethyl pateamine A. (2021) (12)
- SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation (2022) (12)
- eIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways (2018) (12)
- Denys-Drash syndrome: a role for the WT1 tumour suppressor gene in urogenital development (1994) (12)
- Pterocarpans and isoflavones from the root bark of Millettia micans and of Millettia dura (2017) (12)
- Throwing a monkey wrench in the motor: targeting DExH/D box proteins with small molecule inhibitors. (2013) (12)
- Regulation of renal EGF receptor expression is normal in Denys-Drash syndrome. (1997) (11)
- Genome-wide search for exonic variants affecting translational efficiency (2013) (11)
- The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest. (2020) (10)
- Eukaryotic initiation factor 4F-sidestepping resistance mechanisms arising from expression heterogeneity. (2018) (10)
- Characterization of an abundant short interspersed nuclear element (SINE) present in Canis familiaris (2009) (10)
- Flavonoid glycosides from Adina racemosa and their inhibitory activities on eukaryotic protein synthesis. (2004) (10)
- Regulation of Eukaryotic Initiation Factor 4AII by MyoD during Murine Myogenic Cell Differentiation (2014) (9)
- Overlapping DNA recognition motifs between Sp1 and a novel trans-acting factor within the wt1 tumour suppressor gene promoter. (1997) (9)
- The Wilms' tumor suppressor gene (wt1) product represses different functional classes of transcriptional activation domains. (1999) (9)
- Expression of Reovirus Type 3 (Dearing) σ1 and σs Polypeptides in Escherichia coli (1987) (9)
- Homogenous time resolved fluorescence assay to identify modulators of cap-dependent translation initiation. (2007) (8)
- Effect of 2′-5′/3′-5′ phosphodiester linkage heterogeneity on RNA interference (2020) (8)
- Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice (2021) (8)
- Developing anti-neoplastic biotherapeutics against eIF4F (2017) (8)
- SMARCB1 loss induces druggable cyclin D1 deficiency via upregulation of MIR17HG in atypical teratoid rhabdoid tumors (2020) (8)
- Abnormal gonadal differentiation in two subjects with ambiguous genitalia, Mullerian structures, and normally developed testes: Evidence for a defect in gonadal ridge development (1996) (8)
- TC-PTP regulates the IL-7 transcriptional response during murine early T cell development (2017) (8)
- USP44 is dispensable for normal hematopoietic stem cell function, lymphocyte development, and B-cell-mediated immune response in a mouse model. (2019) (8)
- Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia (2013) (8)
- Tracing MYC Expression for Small Molecule Discovery. (2019) (7)
- Problems with Co-Funding in Canada (2005) (7)
- The Molecular Genetics of Wilms Tumor (1996) (7)
- Eukaryotic Translation Initiation Factor 4AI: A Potential Novel Target in Neuroblastoma (2021) (7)
- Nephropathy with Wilms tumour or gonadal dysgenesis: Incomplete Denys-Drash syndrome or separate diseases? (1995) (7)
- A set of canine interrepeat sequence PCR markers for high-throughput genotyping. (2000) (6)
- [11] Mutational detection by single-strand conformational polymorphism (1995) (6)
- A New Natural Product Analog of Blasticidin S Reveals Cellular Uptake Facilitated by the NorA Multidrug Transporter (2017) (6)
- Molecular genetics of Wilms' tumor: insights into normal and abnormal renal development. (1994) (6)
- Identification of the 80-kDa protein that crosslinks to the cap structure of eukaryotic mRNAs as initiation factor eIF-4B. (1988) (6)
- Assessing eukaryotic initiation factor 4F subunit essentiality by CRISPR-induced gene ablation in the mouse (2021) (6)
- Inhibiting mitochondrial-dependent proteolysis of Mcl-1 promotes resistance to DNA damage (2012) (5)
- A New Benzopyranyl Cadenane Sesquiterpene and Other Antiplasmodial and Cytotoxic Metabolites from Cleistochlamys kirkii (2019) (5)
- A Meroisoprenoid, Heptenolides, and C-Benzylated Flavonoids from Sphaerocoryne gracilis ssp. gracilis (2020) (5)
- Establishment of a Primary Screening Assay for the DHX9 Helicase. (2015) (4)
- F329L polymorphism in the human PAX8 gene. (1997) (4)
- Dependence of p53-deficient cells on the DHX9 DExH-box helicase (2017) (4)
- Loss of MYSM1 inhibits the oncogenic activity of cMYC in B cell lymphoma (2021) (4)
- Targeting DEAD‐box RNA helicases: The emergence of molecular staples (2022) (4)
- Data in support of a harmine-derived beta-carboline in vitro effects in cancer cells through protein synthesis (2017) (4)
- Correction: 2'-O-methylation of the mRNA cap protects RNAs from decapping and degradation by DXO (2018) (3)
- Absence of p 53 Gene Mutations in Primary Neuroblastomas 1 (2006) (3)
- CRISPR/Cas9 Editing to Facilitate and Expand Drug Discovery. (2018) (3)
- A novel mutation H373Y in the Wilms' tumor suppressor gene, WT1, associated with Denys-Drash syndrome. (1996) (3)
- A conserved homo-dimerization interface in human IFIT1 provides insights into IFIT interactome assembly (2017) (3)
- Stimulators of translation identified during a small molecule screening campaign. (2014) (3)
- Error in Figure. (2017) (2)
- A CRISPR-based Screen Links an Inhibitor of Nonsense-mediated Decay to eIF4A3 Target Engagement. (2020) (2)
- The mTORC1/S6K/PDCD4/eIF4A axis determines outcome of mitosis (2019) (2)
- Methionine Sustituted Polyamides are RNAse Mimics that Inhibit Translation (2004) (2)
- TACIMA-218: A Novel Pro-Oxidant Agent Exhibiting Selective Antitumoral Activity (2020) (1)
- Correction for Dauber et al., “The Herpes Simplex Virus 1 vhs Protein Enhances Translation of Viral True Late mRNAs and Virus Production in a Cell Type-Dependent Manner” (2019) (1)
- Evolution of naturally arising SARS-CoV-2 defective interfering particles (2022) (1)
- Trans-spliced mRNA products produced from circRNA expression vectors (2021) (1)
- RNA Helicases and Their Cofactors (2014) (1)
- A cautionary note on the use of cap analogue affinity resins. (2018) (1)
- Downstream from mTOR: Therapeutic Approaches to Targeting the eIF4F Translation Initiation Complex (2009) (1)
- FAS Mutations Accelerate Lymphoma Growth and Induce Therapeutic Resistance (2014) (1)
- Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia (2013) (1)
- Chemical Synthesis Enables Structural Reengineering of Aglaroxin C Leading to Inhibition Bias for HCV Infection (2019) (1)
- Modulation of RNA condensation by the eIF4A RNA helicase (2019) (1)
- A forward genetic screen identifies modifiers of rocaglate responsiveness (2021) (1)
- The Herpes Simplex Virus 1 vhs Protein Enhances Translation of Viral True Late mRNAs and Virus Production in a Cell Type-Dependent Manner (cid:1) † (2011) (0)
- high-throughput genotyping A set of canine interrepeat sequence PCR markers for (2015) (0)
- Errata (1933) (0)
- Supplemental Information CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase , eIF 4 A (0)
- Abstract 6507: Inhibition of the translation initiation factor eIF4A1 enhances tumor cell radiosensitivity (2020) (0)
- Helicases implicated in general translation initiation — eIF 4 AI ( DDX 2 A ) , eIF (2012) (0)
- Abstract IA13: Targeting redox dependencies in pancreatic cancer (2020) (0)
- Current and Emerging Therapies Targeting Translation (2014) (0)
- With trp proteins related protein MTR1 and this DNA sequence encoding (2000) (0)
- Poster Session 2 : Apoptosis and Cell Cycle Oncogenes and Tumor Suppressor Genes ; Synergistic activation of transcription by hTAFII68(NTD) and v-Src (2004) (0)
- De novo protein synthesis in distinct centrolateral amygdala interneurons is required for associative emotional memories (2020) (0)
- Protein tyrosine phosphatases in hematopoietic development (2014) (0)
- Translationinitiation:acritical signallingnodeincancer (2009) (0)
- Puglisi Single-Molecule Analysis of Translational Dynamics Subject Collection Protein Synthesis and Translational Control Dynamics Single-Molecule Analysis of Translational (2012) (0)
- Single Molecule Studies Revealing the Dynamics of RNA Helicase eIF4A (2010) (0)
- Inhibiting Translation as a Novel Strategy to Target Multiple Myeloma (2010) (0)
- Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing (2015) (0)
- potentiationent hippocampal long-term Multiple components of eIF4F are required for protein (2015) (0)
- Abstract 684: Inhibition of translation by aglaiastatins: Mechanism of action (2018) (0)
- Magnesium sensitive uORF controls PRL phosphatase expression to mediate energy metabolism (2019) (0)
- eIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways (2018) (0)
- An oncogenome-based RNAi screen identifies a tumour suppressor network in B-cell lymphoma relying on the polyamine-hypusine axis (2012) (0)
- Targeting Oncoprotein Translation with Rocaglates in MYC-Driven Lymphoma (2018) (0)
- Inhibition of the translation initiation factor eIF4A enhances tumor cell radiosensitivity. (2022) (0)
- Clonal expansion to anaplasia in Wilms` tumors is associated with p53 mutations (1994) (0)
- Abstracts of the 52nd Workshop for Pediatric Research (2017) (0)
- Deciphering the Mechanism of RNA helicase eIF4A in Translation Initiation (2009) (0)
- Single-Molecule Studies of the Effects of Small Compounds on the Activity of Translation Initiation Factor eIF4A (2011) (0)
- Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation (2019) (0)
- 253 INVITED Exploring translation initiation as a therapeutic target (2008) (0)
- Expression of reovirus type 3 (Dearing) sigma 1 and sigma s polypeptides in Escherichia coli. (1987) (0)
- Exploring the Targeting Spectrum of Rocaglates Among eIF4A Homologs. (2023) (0)
- CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary (2019) (0)
- Contents, Vol. 46, 1996 (1993) (0)
- TC-PTP regulates the IL-7 transcriptional response during murine early T cell development (2017) (0)
- Translational Efficiency ofPoliovirus mRNA:MappingInhibitory cis-Acting Elements within the5'Noncoding Region (1988) (0)
- Anticancer activity of resveratrol analogs from Eugenia rigida DC (2012) (0)
- Gene Mutations in Primary Neuroblastomas p 53 Absence of Updated Version (2006) (0)
- Developing anti-neoplastic biotherapeutics against eIF4F (2016) (0)
- Abstract B17: Dexamethasone synthetic lethal screens uncover two potential combination therapies for the treatment of multiple myeloma (2013) (0)
- Kaiso mediates human ICR1 methylation maintenance and H19 transcriptional fine regulation (2016) (0)
- Cycloheximide and Congeners as Inhibitors of Eukaryotic Protein Synthesis from Endophytic Actinomycetes Streptomyces sps. YIM56132 and YIM56141. (2011) (0)
- P-163 HIPPURISTANOL : A SELECTIVE INHIBITOR OF RNA HELICASE eIF4A (2006) (0)
- Curtailing Mammalian Target of Rapamycin Signaling The Antidepressant Sertraline Inhibits Translation Initiation (2010) (0)
- Chemical and CRISPR/Cas9 Tools for Functional Characterization of RNA Helicases (2018) (0)
- Acknowledgement to the Reviewers, Vol. 46, 1996 (1996) (0)
- Inflection and Representation (2018) (0)
- Error in Figure. (2016) (0)
- Error in Figure. (2019) (0)
- Cover Image (2021) (0)
- Introduction (2018) (0)
- Engineering a Potent Cancer Vaccine Using Immunoproteasome-Expressing Mesenchymal Stromal Cells (2021) (0)
- within the human vitamin D receptor gene promoter Functional characterization of WT1 binding sites (2015) (0)
- Abstract 959: FAS mutations induce therapeutic resistance in non-Hodgkin lymphomas (2014) (0)
- Therapeutic targeting of eukaryotic initiation factor (eIF) 4E. (2023) (0)
- Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome (2017) (0)
- Abstract B075: eIF4A regulates ERK activation by controlling the translation of DUSP6 (2019) (0)
- Obatoclax is a direct and potent antagonist of membrane-restricted Mcl-1 and is synthetic lethal with treatment that induces Bim (2015) (0)
- Translatome analysis of Tuberous Sclerosis Complex-1 patient-derived neural progenitor cells reveal rapamycin-dependent and independent alterations (2023) (0)
- Subject Index Vol. 46, 1996 (1996) (0)
- Competition of bacteriophage polypeptides with native replicase proteins for binding to the DNA sliding clamp reveals a novel mechanism for DNA replication arrest in Staphylococcus aureus (2006) (0)
- related with TRP proteins protein MTR1 and this DNA sequence encoding (1999) (0)
- LYMPHOID NEOPLASIA RNA i screening uncovers Dhx9 as a modi fi er of ABT-737 resistance in an E m - myc /Bcl-2 mouse model (2013) (0)
- Synthesis of (-)-Silvestrol (2008) (0)
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What Schools Are Affiliated With Jerry Pelletier?
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