Jerry Pelletier

Jerry Pelletier's AcademicInfluence.com Rankings

Jerry Pelletier

Chemistry

#2477

World Rank

#3390

Historical Rank

Chemical Engineering

#236

World Rank

#250

Historical Rank

Organic Chemistry

#363

World Rank

#430

Historical Rank

chemistry Degrees

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Chemistry

Jerry Pelletier's Degrees

PhD Chemistry University of California, Berkeley
Masters Chemical Engineering Stanford University
Bachelors Chemical Engineering Stanford University

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Jerry Pelletier's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

WT-1 is required for early kidney development (1993) (1963)
Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA (1988) (1851)
Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus (1990) (1813)
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy (2004) (979)
Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome (1991) (914)
The candidate Wilms' tumour gene is involved in genitourinary development (1990) (874)
Short RNAs repress translation after initiation in mammalian cells. (2006) (840)
Statistical practice in high-throughput screening data analysis (2006) (679)
Alternative splicing and genomic structure of the Wilms tumor gene WT1. (1991) (604)
Targeting the translation machinery in cancer (2015) (595)
An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor (1990) (586)
Insertion mutagenesis to increase secondary structure within the 5′ noncoding region of a eukaryotic mRNA reduces translational efficiency (1985) (532)
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer (2014) (471)
The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo. (2015) (457)
Dissecting eIF4E action in tumorigenesis. (2007) (455)
WT1 mutations contribute to abnormal genital system development and hereditary Wilms' tumour (1991) (443)
Expression of the Wilms' tumor gene WT1 in the murine urogenital system. (1991) (443)
eIF2α Phosphorylation Bidirectionally Regulates the Switch from Short- to Long-Term Synaptic Plasticity and Memory (2007) (406)
Target identification using drug affinity responsive target stability (DARTS) (2009) (383)
Target identification using drug affinity responsive target stability (DARTS). (2009) (348)
Nuclear localization of the protein encoded by the Wilms' tumor gene WT1 in embryonic and adult tissues. (1993) (341)
The complete genomes and proteomes of 27 Staphylococcus aureus bacteriophages. (2005) (339)
Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A (2006) (327)
Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation. (2006) (304)
Anaplastic Wilms' tumour, a subtype displaying poor prognosis, harbours p53 gene mutations (1994) (296)
Cap-independent translation of poliovirus mRNA is conferred by sequence elements within the 5' noncoding region (1988) (294)
Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model. (2008) (290)
Targeting the eIF4F translation initiation complex: a critical nexus for cancer development. (2015) (265)
A cellular protein that binds to the 5'-noncoding region of poliovirus RNA: implications for internal translation initiation. (1989) (263)
mTORC1 promotes survival through translational control of Mcl-1 (2008) (259)
Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development (1991) (258)
Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol (2009) (254)
Antimicrobial drug discovery through bacteriophage genomics (2004) (214)
Structural conservation of druggable hot spots in protein–protein interfaces (2011) (208)
Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation. (2005) (205)
Absence of p53 gene mutations in primary neuroblastomas. (1993) (204)
Germline intronic and exonic mutations in the Wilms' tumour gene (WT1) affecting urogenital development (1992) (198)
Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing (2015) (191)
Structural and functional analysis of the ribosome landing pad of poliovirus type 2: in vivo translation studies (1991) (184)
Sequence and structural requirements for high-affinity DNA binding by the WT1 gene product (1995) (182)
Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases. (2011) (179)
High-Throughput Screening of G Protein-Coupled Receptor Antagonists Using a Bioluminescence Resonance Energy Transfer 1-Based β-Arrestin2 Recruitment Assay (2005) (176)
nanoCAGE reveals 5′ UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs (2016) (171)
Uncoupling stress granule assembly and translation initiation inhibition. (2009) (169)
c-Myc and eIF4F are components of a feedforward loop that links transcription and translation. (2008) (160)
Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F (2010) (153)
Evidence for a familial Wilms' tumour gene (FWT1) on chromosome 17q12–q21 (1996) (150)
The Wilms’ Tumor Suppressor Gene (wt1) Product Regulates Dax-1 Gene Expression during Gonadal Differentiation (1999) (149)
A Non-AUG Translational Initiation Event Generates Novel WT1 Isoforms (*) (1996) (148)
Comparative Genomic Analysis of 18 Pseudomonas aeruginosa Bacteriophages (2006) (147)
Caliciviruses Differ in Their Functional Requirements for eIF4F Components* (2006) (146)
The Organizing Principles of Eukaryotic Ribosome Recruitment. (2019) (145)
Microdeletion of target sites for insulator protein CTCF in a chromosome 11p15 imprinting center in Beckwith-Wiedemann syndrome and Wilms' tumor. (2005) (143)
RNA-mediated sequestration of the RNA helicase eIF4A by Pateamine A inhibits translation initiation. (2006) (138)
Clonal expansion and attenuated apoptosis in Wilms' tumors are associated with p53 gene mutations. (1995) (135)
Inhibitors of protein synthesis identified by a high throughput multiplexed translation screen. (2004) (133)
The paired-box transcription factor, PAX2, positively modulates expression of the Wilms' tumor suppressor gene (WT1). (1996) (130)
Fine structure analysis of the WT1 gene in sporadic Wilms tumors. (1994) (129)
A tumour suppressor network relying on the polyamine–hypusine axis (2012) (128)
Modulation of RNA Condensation by the DEAD-Box Protein eIF4A (2019) (127)
Repurposing CRISPR/Cas9 for in situ functional assays (2013) (127)
Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability. (2006) (126)
Internal binding of eucaryotic ribosomes on poliovirus RNA: translation in HeLa cell extracts (1989) (126)
MicroRNAs trigger dissociation of eIF4AI and eIF4AII from target mRNAs in humans. (2014) (126)
Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression. (2000) (124)
Characterization of hMTr1, a Human Cap1 2′-O-Ribose Methyltransferase* (2010) (121)
Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs. (2008) (118)
Mutational analysis of upstream AUG codons of poliovirus RNA (1988) (117)
Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas (2010) (114)
Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo. (2006) (113)
Tumorigenic activity and therapeutic inhibition of Rheb GTPase. (2008) (112)
Selective Pharmacological Targeting of a DEAD Box RNA Helicase (2008) (110)
Translation in mammalian cells of a gene linked to the poliovirus 5' noncoding region. (1988) (109)
Antagonism of WT1 activity by protein self-association. (1995) (107)
Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma (2011) (106)
New Ways of Initiating Translation in Eukaryotes? (2001) (104)
The biology of DHX9 and its potential as a therapeutic target (2016) (103)
Repression of the retinoic acid receptor-alpha gene by the Wilms' tumor suppressor gene product, wt1. (1995) (102)
Inhibition of translation by RNA-small molecule interactions. (2002) (102)
Protospacer Adjacent Motif (PAM)-Distal Sequences Engage CRISPR Cas9 DNA Target Cleavage (2014) (101)
The murine Sim-2 gene product inhibits transcription by active repression and functional interference (1997) (98)
Overlapping RNA and DNA binding domains of the wt1 tumor suppressor gene product. (1998) (98)
A mammalian translation initiation factor can substitute for its yeast homologue in vivo. (1989) (98)
Evidence for a functionally relevant rocaglamide binding site on the eIF4A-RNA complex. (2013) (96)
Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone. (1997) (95)
Translation Initiation Factors: Reprogramming Protein Synthesis in Cancer. (2016) (94)
Enantioselective synthesis of the complex rocaglate (-)-silvestrol. (2007) (93)
Altering Chemosensitivity by Modulating Translation Elongation (2009) (89)
Exploring the Impact of Single-Nucleotide Polymorphisms on Translation (2018) (87)
A cellular response linking eIF4AI activity to eIF4AII transcription. (2012) (87)
An efficient strategy to isolate full-length cDNAs based on an mRNA cap retention procedure (CAPture) (1995) (86)
Differential efficiencies of in vitro translation of mouse c-myc transcripts differing in the 5' untranslated region. (1985) (86)
Photochemical cross-linking of cap binding proteins to eucaryotic mRNAs: effect of mRNA 5' secondary structure (1985) (85)
Blocking eIF4E-eIF4G Interaction as a Strategy To Impair Coronavirus Replication (2011) (85)
The involvement of mRNA secondary structure in protein synthesis. (1987) (84)
A Novel Function of eIF2α Kinases as Inducers of the Phosphoinositide-3 Kinase Signaling Pathway (2007) (83)
Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing (2010) (83)
Targeting synthetic lethal interactions between Myc and the eIF4F complex impedes tumorigenesis. (2012) (82)
PAX2 Activates WNT4 Expression during Mammalian Kidney Development* (2006) (81)
A lysine substitution in the ATP-binding site of eucaryotic initiation factor 4A abrogates nucleotide-binding activity (1989) (79)
Synthesis of rocaglamide hydroxamates and related compounds as eukaryotic translation inhibitors: synthetic and biological studies. (2012) (79)
eIF4F suppression in breast cancer affects maintenance and progression (2013) (78)
Analysis of the 11p13 Wilms' tumor suppressor gene (WT1) in ovarian tumors. (1993) (76)
CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A (2016) (73)
Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2′-O methylations (2017) (73)
PAX8‐mediated activation of the wt1 tumor suppressor gene. (1996) (71)
Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain. (1998) (71)
Molecular genetics of chromosome translocations involving EWS and related family members. (1999) (70)
WT1 mutations associated with incomplete Denys-Drash syndrome define a domain predicted to behave in a dominant-negative fashion. (1994) (70)
Translational efficiency of poliovirus mRNA: mapping inhibitory cis-acting elements within the 5' noncoding region (1988) (68)
The Herpes Simplex Virus 1 vhs Protein Enhances Translation of Viral True Late mRNAs and Virus Production in a Cell Type-Dependent Manner (2011) (68)
A modular and flexible ESC-based mouse model of pancreatic cancer (2014) (68)
The desmoplastic small round cell tumor t(11;22) translocation produces EWS/WT1 isoforms with differing oncogenic properties (1998) (66)
The effect of poliovirus proteinase 2Apro expression on cellular metabolism. Inhibition of DNA replication, RNA polymerase II transcription, and translation. (1991) (66)
Full-length cDNAs: more than just reaching the ends. (2001) (65)
CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary (2019) (65)
Targeting Translation Dependence in Cancer (2011) (64)
Eukaryotic protein synthesis inhibitors identified by comparison of cytotoxicity profiles. (2004) (63)
Identification of a new polypeptide coded by reovirus gene S1 (1985) (63)
Translation of nonSTOP mRNA is repressed post‐initiation in mammalian cells (2007) (62)
Identification of nuclear localization signals within the zinc fingers of the WT1 tumor suppressor gene product (1996) (62)
NAP-2: histone chaperone function and phosphorylation state through the cell cycle. (2000) (62)
Targeting the eIF4A RNA helicase as an anti-neoplastic approach. (2015) (62)
Different transcriptional properties of mSim‐1 and mSim‐2 (2000) (62)
Conditional Reverse Tet-Transactivator Mouse Strains for the Efficient Induction of TRE-Regulated Transgenes in Mice (2014) (61)
c-Myc and eIF4F constitute a feedforward loop that regulates cell growth: implications for anticancer therapy. (2009) (61)
The Yeast Split-Ubiquitin Membrane Protein Two-Hybrid Screen Identifies BAP31 as a Regulator of the Turnover of Endoplasmic Reticulum-Associated Protein Tyrosine Phosphatase-Like B (2004) (60)
Constitutional WT1 mutations in Wilms' tumor patients. (1998) (59)
Genomic organization of the canine p53 gene and its mutational status in canine mammary neoplasia (1998) (58)
Emerging therapeutics targeting mRNA translation. (2012) (58)
2'-Fluoro-4'-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity. (2007) (58)
Synergistic effect of inhibiting translation initiation in combination with cytotoxic agents in acute myelogenous leukemia cells. (2010) (58)
A new antimalarial quassinoid from Simaba orinocensis. (2004) (57)
The translation inhibitor pateamine A prevents cachexia-induced muscle wasting in mice (2012) (57)
Assessment of the total number of human transcription units. (2001) (56)
Modifying chemotherapy response by targeted inhibition of eukaryotic initiation factor 4A (2013) (56)
Hepatitis C virus-related internal ribosome entry sites are found in multiple genera of the family Picornaviridae. (2006) (55)
Triaminotriazine DNA helicase inhibitors with antibacterial activity. (2006) (52)
A dominant mutation in the Wilms tumor gene WT1 cooperates with the viral oncogene E1A in transformation of primary kidney cells. (1992) (51)
Biomimetic photocycloaddition of 3-hydroxyflavones: synthesis and evaluation of rocaglate derivatives as inhibitors of eukaryotic translation. (2010) (50)
Cap-dependent eukaryotic initiation factor-mRNA interactions probed by cross-linking. (2008) (50)
The antidepressant sertraline inhibits translation initiation by curtailing mammalian target of rapamycin signaling. (2010) (48)
Structure-activity relationships of quassinoids for eukaryotic protein synthesis. (2005) (48)
Multiple mRNAs encode the murine translation initiation factor eIF-4E. (1991) (47)
Translation initiation factor eIF4F modifies the dexamethasone response in multiple myeloma (2014) (47)
Persistent Transcription- and Translation-Dependent Long-Term Potentiation Induced by mGluR1 in Hippocampal Interneurons (2009) (46)
An upstream open reading frame impedes translation of the huntingtin gene. (2002) (46)
Functional characterization of WT1 binding sites within the human vitamin D receptor gene promoter. (2001) (46)
Synthesis of the antiproliferative agent hippuristanol and its analogues via Suárez cyclizations and Hg(II)-catalyzed spiroketalizations. (2011) (45)
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma (2019) (45)
Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance (2016) (45)
Insights into the physiological role of WT1 from studies of genetically modified mice. (2004) (45)
A novel function of eIF2alpha kinases as inducers of the phosphoinositide-3 kinase signaling pathway. (2007) (44)
Chlorolissoclimides: new inhibitors of eukaryotic protein synthesis. (2006) (44)
2′,3′‐Cyclic nucleotide 3′‐phosphodiesterase: A novel RNA‐binding protein that inhibits protein synthesis (2009) (43)
Translation initiation: a critical signalling node in cancer (2009) (43)
Ribavirin is not a functional mimic of the 7-methyl guanosine mRNA cap. (2005) (43)
Dissecting eIF 4 E action in tumorigenesis Material Supplemental (2007) (43)
2'-O-methylation of the mRNA cap protects RNAs from decapping and degradation by DXO (2018) (42)
Inhibitors of translation initiation as cancer therapeutics. (2009) (42)
A harmine‐derived beta‐carboline displays anti‐cancer effects in vitro by targeting protein synthesis (2017) (42)
The DNA binding domains of the WT1 tumor suppressor gene product and chimeric EWS/WT1 oncoprotein are functionally distinct (1998) (41)
Single-molecule kinetics of the eukaryotic initiation factor 4AI upon RNA unwinding. (2014) (41)
Hippuristanol - A potent steroid inhibitor of eukaryotic initiation factor 4A (2016) (41)
PAM multiplicity marks genomic target sites as inhibitory to CRISPR-Cas9 editing (2015) (41)
A new class of small molecule RNA polymerase inhibitors with activity against rifampicin-resistant Staphylococcus aureus. (2006) (41)
WT1 is a modifier of the Pax2 mutant phenotype: cooperation and interaction between WT1 and Pax2 (2003) (40)
Efficient synthetic approach to potent antiproliferative agent hippuristanol via Hg(II)-catalyzed spiroketalization. (2010) (40)
Experimental Design and Statistical Methods for Improved Hit Detection in High-Throughput Screening (2010) (40)
Tumor Cell Survival Dependence on the DHX9 DExH-Box Helicase (2016) (39)
The eukaryotic initiation factor eIF4H facilitates loop-binding, repetitive RNA unwinding by the eIF4A DEAD-box helicase (2012) (39)
Minor C-geranylated flavanones from Paulownia tomentosa fruits with MRSA antibacterial activity. (2013) (39)
Microdeletion and IGF2 loss of imprinting in a cascade causing Beckwith-Wiedemann syndrome with Wilms' tumor (2005) (39)
Perturbations of RNA helicases in cancer (2013) (39)
Characterization of msim, a murine homologue of the Drosophila sim transcription factor. (1996) (39)
Targeting protein synthesis in a Myc/mTOR-driven model of anorexia-cachexia syndrome delays its onset and prolongs survival. (2012) (38)
Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm (2015) (37)
Silibinin inhibits translation initiation: implications for anticancer therapy (2009) (37)
The human steroidogenic acute regulatory (StAR) gene is expressed in the urogenital system and encodes a mitochondrial polypeptide. (1995) (37)
Activation of the wt1 Wilms' tumor suppressor gene by NF-κB (1998) (37)
Nucleotide binding and nucleotide hydrolysis properties of the ABC transporter MRP6 (ABCC6). (2002) (36)
Translation initiation factor-dependent extracts from Saccharomyces cerevisiae. (1990) (36)
eIF4AII is dispensable for miRNA-mediated gene silencing (2015) (35)
Beyond molecular tumor heterogeneity: protein synthesis takes control (2018) (35)
Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F (2020) (35)
Poliovirus translation: A paradigm for a novel initiation mechanism (1989) (34)
Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer. (2016) (34)
Familial Wilms' tumor associated with a WT1 zinc finger mutation. (1996) (34)
Phenylpyrrolocytosine as an unobtrusive base modification for monitoring activity and cellular trafficking of siRNA. (2011) (33)
RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an Eμ-myc/Bcl-2 mouse model. (2013) (33)
Suppression of the DHX9 Helicase Induces Premature Senescence in Human Diploid Fibroblasts in a p53-dependent Manner* (2014) (33)
Modification of EWS/WT1 functional properties by phosphorylation. (1999) (33)
Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors. (2019) (33)
Inhibition of Wilms Tumor 1 Transactivation by Bone Marrow Zinc Finger 2, a Novel Transcriptional Repressor* (2002) (33)
A CRISPR/Cas9 Functional Screen Identifies Rare Tumor Suppressors (2016) (33)
Mitochondrion-dependent N-terminal Processing of Outer Membrane Mcl-1 Protein Removes an Essential Mule/Lasu1 Protein-binding Site* (2011) (32)
Internal Translation Initiation Mediated by the Angiogenic Factor Tie2* (2005) (32)
Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides. (2017) (32)
Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism (2019) (32)
Blocking UV‐Induced eIF2α Phosphorylation with Small Molecule Inhibitors of GCN2 (2009) (32)
O-GlcNAcylation of core components of the translation initiation machinery regulates protein synthesis (2019) (32)
Eukaryotic initiation factor 4F: a vulnerability of tumor cells. (2012) (31)
Requirements for eIF4A and eIF2 during translation of Sindbis virus subgenomic mRNA in vertebrate and invertebrate host cells (2013) (31)
Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition. (2009) (31)
Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation. (2013) (31)
Role of Eukaryotic Messenger RNA Cap-Binding Protein in Regulation of Translation (1987) (27)
The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response. (2009) (27)
Activation of the WT1 tumor suppressor gene promoter by Pea3 (2004) (26)
Functional characterization of ORCTL2 ‐ an organic cation transporter expressed in the renal proximal tubules (1998) (26)
Modulation of EWS/WT1 activity by the v‐Src protein tyrosine kinase (2000) (26)
Isoflavones and Rotenoids from the Leaves of Millettia oblata ssp. teitensis. (2017) (25)
General and Target-Specific DExD/H RNA Helicases in Eukaryotic Translation Initiation (2020) (25)
Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition. (2016) (25)
Tumor progression and metastasis: role of translational deregulation. (2012) (24)
Polyoxygenated Cyclohexenes and Other Constituents of Cleistochlamys kirkii Leaves. (2017) (24)
her-2 upstream open reading frame effects on the use of downstream initiation codons. (2006) (24)
Therapeutic Opportunities in Eukaryotic Translation. (2018) (24)
Stimulation of hTAFII68 (NTD)‐mediated transactivation by v‐Src (2004) (23)
Competition of bacteriophage polypeptides with native replicase proteins for binding to the DNA sliding clamp reveals a novel mechanism for DNA replication arrest in Staphylococcus aureus (2006) (23)
Activation of the wt1 Wilms' tumor suppressor gene by NF-kappaB. (1998) (23)
Cycloheximide and congeners as inhibitors of eukaryotic protein synthesis from endophytic actinomycetes Streptomyces sps. YIM56132 and YIM56141 (2011) (23)
Selective targeting of the DEAD-box RNA helicase eukaryotic initiation factor (eIF) 4A by natural products. (2019) (22)
Increased in vitro and in vivo sensitivity of BRCA2-associated pancreatic cancer to the poly(ADP-ribose) polymerase-1/2 inhibitor BMN 673. (2015) (22)
2′-Fluoro-4′-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity (2007) (22)
Identification of compounds that decrease the fidelity of start codon recognition by the eukaryotic translational machinery. (2011) (22)
Amygdala inhibitory neurons as loci for translation in emotional memories (2020) (22)
Obatoclax is a direct and potent antagonist of membrane-restricted Mcl-1 and is synthetic lethal with treatment that induces Bim (2015) (21)
Inhibitory properties of nucleic acid‐binding ligands on protein synthesis (2005) (21)
Inhibition of Transcription in Staphylococcus aureus by a Primary Sigma Factor-Binding Polypeptide from Phage G1 (2009) (21)
Rocaglates as dual-targeting agents for experimental cerebral malaria (2018) (21)
Chemical Synthesis Enables Structural Reengineering of Aglaroxin C Leading to Inhibition Bias for Hepatitis C Viral Infection. (2018) (21)
Identifying small molecule inhibitors of eukaryotic translation initiation. (2007) (21)
Desmocollin 1 is abundantly expressed in atherosclerosis and impairs high-density lipoprotein biogenesis (2018) (21)
Intercepted Retro-Nazarov Reaction: Syntheses of Amidino-Rocaglate Derivatives and Their Biological Evaluation as eIF4A Inhibitors. (2019) (20)
Forced engagement of a RNA/protein complex by a chemical inducer of dimerization to modulate gene expression (2002) (20)
Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response (2017) (20)
Alternative splicing and genomic structure of the Wilms tumor gene WT 1 ( alternative splicing / genomic structure (20)
The von Hippel-Lindau Protein pVHL Inhibits Ribosome Biogenesis and Protein Synthesis* (2013) (19)
Inhibitors of translation targeting eukaryotic translation initiation factor 4A. (2012) (19)
Gene expression studies for the analysis of domoic acid production in the marine diatom Pseudo-nitzschia multiseries (2013) (19)
Adapting CRISPR/Cas9 for functional genomics screens. (2014) (19)
Nuclear assortment of eIF4E coincides with shut-off of host protein synthesis upon poliovirus infection. (2010) (19)
eIF4A Inhibitors Suppress Cell-Cycle Feedback Response and Acquired Resistance to CDK4/6 Inhibition in Cancer (2019) (18)
The human insulin mRNA is partly translated via a cap- and eIF4A-independent mechanism. (2011) (18)
Inhibition of translation by cytotrienin A--a member of the ansamycin family. (2010) (17)
Drug-induced Stress Granule Formation Protects Sensory Hair Cells in Mouse Cochlear Explants During Ototoxicity (2019) (17)
30 Therapeutic Opportunities in Translation (2007) (17)
Translation Inhibition by Rocaglates Is Independent of eIF4E Phosphorylation Status (2015) (17)
A chemical genetic screen for mTOR pathway inhibitors based on 4E-BP-dependent nuclear accumulation of eIF4E. (2009) (16)
Differential action of pateamine A on translation of genomic and subgenomic mRNAs from Sindbis virus. (2015) (16)
Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation (2019) (16)
A comparative study of small molecules targeting eIF4A (2020) (16)
Downregulation of PTP1B and TC-PTP phosphatases potentiate dendritic cell-based immunotherapy through IL-12/IFNγ signaling (2017) (15)
Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5′ leader regions (2020) (15)
Wilms' tumor: a paradigm for insights into development and cancer. (1995) (15)
Assignment of two of the translation initiation factor-4E (EIF4EL1 and EIF4EL2) genes to human chromosomes 4 and 20. (1991) (15)
Internal translation initiation from HIV-1 transcripts is conferred by a common RNA structure (2014) (15)
Inducible Genome Editing with Conditional CRISPR/Cas9 Mice (2018) (15)
RNA-tethering assay and eIF4G:eIF4A obligate dimer design uncovers multiple eIF4F functional complexes (2020) (14)
Inhibition of protein synthesis by aminoglycoside-arginine conjugates. (2002) (14)
High-throughput assays probing protein-RNA interactions of eukaryotic translation initiation factors. (2009) (14)
The multifaceted eukaryotic cap structure (2020) (14)
A Novel Function of eIF 2 Kinases as Inducers of the Phosphoinositide-3 Kinase Signaling Pathway (2007) (13)
Kaiso mediates human ICR1 methylation maintenance and H19 transcriptional fine regulation (2016) (13)
5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells. (2016) (13)
Synthesis of the antiproliferative agent hippuristanol and its analogues from hydrocortisone via Hg(II)-catalyzed spiroketalization: structure-activity relationship. (2014) (13)
Germline WT1 mutations in Wilms' tumor patients: preliminary results. (1996) (13)
The Tie2 5′ untranslated region is inhibitory to 5′ end‐mediated translation initiation (2006) (13)
Functional mimicry revealed by the crystal structure of an eIF4A:RNA complex bound to the interfacial inhibitor, desmethyl pateamine A. (2021) (12)
SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation (2022) (12)
eIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways (2018) (12)
Denys-Drash syndrome: a role for the WT1 tumour suppressor gene in urogenital development (1994) (12)
Pterocarpans and isoflavones from the root bark of Millettia micans and of Millettia dura (2017) (12)
Throwing a monkey wrench in the motor: targeting DExH/D box proteins with small molecule inhibitors. (2013) (12)
Regulation of renal EGF receptor expression is normal in Denys-Drash syndrome. (1997) (11)
Genome-wide search for exonic variants affecting translational efficiency (2013) (11)
The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest. (2020) (10)
Eukaryotic initiation factor 4F-sidestepping resistance mechanisms arising from expression heterogeneity. (2018) (10)
Characterization of an abundant short interspersed nuclear element (SINE) present in Canis familiaris (2009) (10)
Flavonoid glycosides from Adina racemosa and their inhibitory activities on eukaryotic protein synthesis. (2004) (10)
Regulation of Eukaryotic Initiation Factor 4AII by MyoD during Murine Myogenic Cell Differentiation (2014) (9)
Overlapping DNA recognition motifs between Sp1 and a novel trans-acting factor within the wt1 tumour suppressor gene promoter. (1997) (9)
The Wilms' tumor suppressor gene (wt1) product represses different functional classes of transcriptional activation domains. (1999) (9)
Expression of Reovirus Type 3 (Dearing) σ1 and σs Polypeptides in Escherichia coli (1987) (9)
Homogenous time resolved fluorescence assay to identify modulators of cap-dependent translation initiation. (2007) (8)
Effect of 2′-5′/3′-5′ phosphodiester linkage heterogeneity on RNA interference (2020) (8)
Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice (2021) (8)
Developing anti-neoplastic biotherapeutics against eIF4F (2017) (8)
SMARCB1 loss induces druggable cyclin D1 deficiency via upregulation of MIR17HG in atypical teratoid rhabdoid tumors (2020) (8)
Abnormal gonadal differentiation in two subjects with ambiguous genitalia, Mullerian structures, and normally developed testes: Evidence for a defect in gonadal ridge development (1996) (8)
TC-PTP regulates the IL-7 transcriptional response during murine early T cell development (2017) (8)
USP44 is dispensable for normal hematopoietic stem cell function, lymphocyte development, and B-cell-mediated immune response in a mouse model. (2019) (8)
Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia (2013) (8)
Tracing MYC Expression for Small Molecule Discovery. (2019) (7)
Problems with Co-Funding in Canada (2005) (7)
The Molecular Genetics of Wilms Tumor (1996) (7)
Eukaryotic Translation Initiation Factor 4AI: A Potential Novel Target in Neuroblastoma (2021) (7)
Nephropathy with Wilms tumour or gonadal dysgenesis: Incomplete Denys-Drash syndrome or separate diseases? (1995) (7)
A set of canine interrepeat sequence PCR markers for high-throughput genotyping. (2000) (6)
[11] Mutational detection by single-strand conformational polymorphism (1995) (6)
A New Natural Product Analog of Blasticidin S Reveals Cellular Uptake Facilitated by the NorA Multidrug Transporter (2017) (6)
Molecular genetics of Wilms' tumor: insights into normal and abnormal renal development. (1994) (6)
Identification of the 80-kDa protein that crosslinks to the cap structure of eukaryotic mRNAs as initiation factor eIF-4B. (1988) (6)
Assessing eukaryotic initiation factor 4F subunit essentiality by CRISPR-induced gene ablation in the mouse (2021) (6)
Inhibiting mitochondrial-dependent proteolysis of Mcl-1 promotes resistance to DNA damage (2012) (5)
A New Benzopyranyl Cadenane Sesquiterpene and Other Antiplasmodial and Cytotoxic Metabolites from Cleistochlamys kirkii (2019) (5)
A Meroisoprenoid, Heptenolides, and C-Benzylated Flavonoids from Sphaerocoryne gracilis ssp. gracilis (2020) (5)
Establishment of a Primary Screening Assay for the DHX9 Helicase. (2015) (4)
F329L polymorphism in the human PAX8 gene. (1997) (4)
Dependence of p53-deficient cells on the DHX9 DExH-box helicase (2017) (4)
Loss of MYSM1 inhibits the oncogenic activity of cMYC in B cell lymphoma (2021) (4)
Targeting DEAD‐box RNA helicases: The emergence of molecular staples (2022) (4)
Data in support of a harmine-derived beta-carboline in vitro effects in cancer cells through protein synthesis (2017) (4)
Correction: 2'-O-methylation of the mRNA cap protects RNAs from decapping and degradation by DXO (2018) (3)
Absence of p 53 Gene Mutations in Primary Neuroblastomas 1 (2006) (3)
CRISPR/Cas9 Editing to Facilitate and Expand Drug Discovery. (2018) (3)
A novel mutation H373Y in the Wilms' tumor suppressor gene, WT1, associated with Denys-Drash syndrome. (1996) (3)
A conserved homo-dimerization interface in human IFIT1 provides insights into IFIT interactome assembly (2017) (3)
Stimulators of translation identified during a small molecule screening campaign. (2014) (3)
Error in Figure. (2017) (2)
A CRISPR-based Screen Links an Inhibitor of Nonsense-mediated Decay to eIF4A3 Target Engagement. (2020) (2)
The mTORC1/S6K/PDCD4/eIF4A axis determines outcome of mitosis (2019) (2)
Methionine Sustituted Polyamides are RNAse Mimics that Inhibit Translation (2004) (2)
TACIMA-218: A Novel Pro-Oxidant Agent Exhibiting Selective Antitumoral Activity (2020) (1)
Correction for Dauber et al., “The Herpes Simplex Virus 1 vhs Protein Enhances Translation of Viral True Late mRNAs and Virus Production in a Cell Type-Dependent Manner” (2019) (1)
Evolution of naturally arising SARS-CoV-2 defective interfering particles (2022) (1)
Trans-spliced mRNA products produced from circRNA expression vectors (2021) (1)
RNA Helicases and Their Cofactors (2014) (1)
A cautionary note on the use of cap analogue affinity resins. (2018) (1)
Downstream from mTOR: Therapeutic Approaches to Targeting the eIF4F Translation Initiation Complex (2009) (1)
FAS Mutations Accelerate Lymphoma Growth and Induce Therapeutic Resistance (2014) (1)
Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia (2013) (1)
Chemical Synthesis Enables Structural Reengineering of Aglaroxin C Leading to Inhibition Bias for HCV Infection (2019) (1)
Modulation of RNA condensation by the eIF4A RNA helicase (2019) (1)
A forward genetic screen identifies modifiers of rocaglate responsiveness (2021) (1)
The Herpes Simplex Virus 1 vhs Protein Enhances Translation of Viral True Late mRNAs and Virus Production in a Cell Type-Dependent Manner (cid:1) † (2011) (0)
high-throughput genotyping A set of canine interrepeat sequence PCR markers for (2015) (0)
Errata (1933) (0)
Supplemental Information CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase , eIF 4 A (0)
Abstract 6507: Inhibition of the translation initiation factor eIF4A1 enhances tumor cell radiosensitivity (2020) (0)
Helicases implicated in general translation initiation — eIF 4 AI ( DDX 2 A ) , eIF (2012) (0)
Abstract IA13: Targeting redox dependencies in pancreatic cancer (2020) (0)
Current and Emerging Therapies Targeting Translation (2014) (0)
With trp proteins related protein MTR1 and this DNA sequence encoding (2000) (0)
Poster Session 2 : Apoptosis and Cell Cycle Oncogenes and Tumor Suppressor Genes ; Synergistic activation of transcription by hTAFII68(NTD) and v-Src (2004) (0)
De novo protein synthesis in distinct centrolateral amygdala interneurons is required for associative emotional memories (2020) (0)
Protein tyrosine phosphatases in hematopoietic development (2014) (0)
Translationinitiation:acritical signallingnodeincancer (2009) (0)
Puglisi Single-Molecule Analysis of Translational Dynamics Subject Collection Protein Synthesis and Translational Control Dynamics Single-Molecule Analysis of Translational (2012) (0)
Single Molecule Studies Revealing the Dynamics of RNA Helicase eIF4A (2010) (0)
Inhibiting Translation as a Novel Strategy to Target Multiple Myeloma (2010) (0)
Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing (2015) (0)
potentiationent hippocampal long-term Multiple components of eIF4F are required for protein (2015) (0)
Abstract 684: Inhibition of translation by aglaiastatins: Mechanism of action (2018) (0)
Magnesium sensitive uORF controls PRL phosphatase expression to mediate energy metabolism (2019) (0)
eIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways (2018) (0)
An oncogenome-based RNAi screen identifies a tumour suppressor network in B-cell lymphoma relying on the polyamine-hypusine axis (2012) (0)
Targeting Oncoprotein Translation with Rocaglates in MYC-Driven Lymphoma (2018) (0)
Inhibition of the translation initiation factor eIF4A enhances tumor cell radiosensitivity. (2022) (0)
Clonal expansion to anaplasia in Wilms` tumors is associated with p53 mutations (1994) (0)
Abstracts of the 52nd Workshop for Pediatric Research (2017) (0)
Deciphering the Mechanism of RNA helicase eIF4A in Translation Initiation (2009) (0)
Single-Molecule Studies of the Effects of Small Compounds on the Activity of Translation Initiation Factor eIF4A (2011) (0)
Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation (2019) (0)
253 INVITED Exploring translation initiation as a therapeutic target (2008) (0)
Expression of reovirus type 3 (Dearing) sigma 1 and sigma s polypeptides in Escherichia coli. (1987) (0)
Exploring the Targeting Spectrum of Rocaglates Among eIF4A Homologs. (2023) (0)
CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary (2019) (0)
Contents, Vol. 46, 1996 (1993) (0)
TC-PTP regulates the IL-7 transcriptional response during murine early T cell development (2017) (0)
Translational Efficiency ofPoliovirus mRNA:MappingInhibitory cis-Acting Elements within the5'Noncoding Region (1988) (0)
Anticancer activity of resveratrol analogs from Eugenia rigida DC (2012) (0)
Gene Mutations in Primary Neuroblastomas p 53 Absence of Updated Version (2006) (0)
Developing anti-neoplastic biotherapeutics against eIF4F (2016) (0)
Abstract B17: Dexamethasone synthetic lethal screens uncover two potential combination therapies for the treatment of multiple myeloma (2013) (0)
Kaiso mediates human ICR1 methylation maintenance and H19 transcriptional fine regulation (2016) (0)
Cycloheximide and Congeners as Inhibitors of Eukaryotic Protein Synthesis from Endophytic Actinomycetes Streptomyces sps. YIM56132 and YIM56141. (2011) (0)
P-163 HIPPURISTANOL : A SELECTIVE INHIBITOR OF RNA HELICASE eIF4A (2006) (0)
Curtailing Mammalian Target of Rapamycin Signaling The Antidepressant Sertraline Inhibits Translation Initiation (2010) (0)
Chemical and CRISPR/Cas9 Tools for Functional Characterization of RNA Helicases (2018) (0)
Acknowledgement to the Reviewers, Vol. 46, 1996 (1996) (0)
Inflection and Representation (2018) (0)
Error in Figure. (2016) (0)
Error in Figure. (2019) (0)
Cover Image (2021) (0)
Introduction (2018) (0)
Engineering a Potent Cancer Vaccine Using Immunoproteasome-Expressing Mesenchymal Stromal Cells (2021) (0)
within the human vitamin D receptor gene promoter Functional characterization of WT1 binding sites (2015) (0)
Abstract 959: FAS mutations induce therapeutic resistance in non-Hodgkin lymphomas (2014) (0)
Therapeutic targeting of eukaryotic initiation factor (eIF) 4E. (2023) (0)
Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome (2017) (0)
Abstract B075: eIF4A regulates ERK activation by controlling the translation of DUSP6 (2019) (0)
Obatoclax is a direct and potent antagonist of membrane-restricted Mcl-1 and is synthetic lethal with treatment that induces Bim (2015) (0)
Translatome analysis of Tuberous Sclerosis Complex-1 patient-derived neural progenitor cells reveal rapamycin-dependent and independent alterations (2023) (0)
Subject Index Vol. 46, 1996 (1996) (0)
Competition of bacteriophage polypeptides with native replicase proteins for binding to the DNA sliding clamp reveals a novel mechanism for DNA replication arrest in Staphylococcus aureus (2006) (0)
related with TRP proteins protein MTR1 and this DNA sequence encoding (1999) (0)
LYMPHOID NEOPLASIA RNA i screening uncovers Dhx9 as a modi ﬁ er of ABT-737 resistance in an E m - myc /Bcl-2 mouse model (2013) (0)
Synthesis of (-)-Silvestrol (2008) (0)

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Victoria University of Wellington
Massachusetts Institute of Technology
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