Jesse Roth
#42,176
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American diabetologist
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#4700
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#960
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#1275
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#1982
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#390
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Philosophy
Jesse Roth's Degrees
- Doctorate Medicine Harvard University
Why Is Jesse Roth Influential?
(Suggest an Edit or Addition)According to Wikipedia, Jesse Roth is an American physician and endocrinologist, currently at The Feinstein Institute for Medical Research. He received his BA in 1955 from Columbia University, his MD in 1959 from Albert Einstein College of Medicine. He completed a residency in internal medicine at Barnes-Jewish Hospital in 1961, and a fellowship in endocrinology at Bronx Veterans Administration Medical Center in 1963. Beginning with his fellowship work with Solomon Berson and Rosalyn Yalow, Jesse Roth's research career focused on insulin action. His laboratory at the National Institutes of Health elucidated much of what we know of the structure of the insulin receptor and intracellular mechanisms of insulin action. Jesse Roth is a fellow of the American College of Physicians and was a recipient of the 1980 Gairdner Foundation International Award and in 1982 he received the American Diabetes Association's Banting Medal for Scientific Achievement.
Jesse Roth's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Reversing established sepsis with antagonists of endogenous high-mobility group box 1 (2003) (1142)
- Insulin receptors are widely distributed in the central nervous system of the rat (1978) (1048)
- The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. (1976) (1021)
- Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture. (1974) (944)
- Phlorizin: a review (2005) (778)
- Novel role of PKR in inflammasome activation and HMGB1 release (2012) (679)
- Insulin interactions with its receptors: experimental evidence for negative cooperativity. (1973) (628)
- Hypoglycemia: A Potent Stimulus to Secretion of Growth Hormone (1963) (602)
- Identification of insulin in rat brain. (1978) (575)
- Insulin Resistance and Hyperinsulinemia (2008) (529)
- Site-site interactions among insulin receptors. Characterization of the negative cooperativity. (1976) (521)
- Monoiodoinsulin: demonstration of its biological activity and binding to fat cells and liver membranes. (1971) (513)
- Molecular Scanning of the Human Peroxisome Proliferator Activated Receptor γ (hPPARγ) Gene in Diabetic Caucasians: Identification of a Pro12Ala PPARγ2 Missense Mutation (1997) (469)
- Insulin receptors in the liver: specific binding of ( 125 I)insulin to the plasma membrane and its relation to insulin bioactivity. (1971) (438)
- Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas (1986) (398)
- Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance (1975) (397)
- Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting. (1976) (391)
- Cooperativity in ligand binding: a new graphic analysis. (1975) (377)
- Insulin-receptor interaction in the obese-hyperglycemic mouse. A model of insulin resistance. (1973) (366)
- Insulin interactions with liver plasma membranes. Independence of binding of the hormone and its degradation. (1972) (342)
- Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations. (1998) (322)
- Concentrations of insulin and insulin receptors in the brain are independent of peripheral insulin levels. Studies of obese and streptozotocin-treated rodents. (1979) (320)
- Regulation of receptor concentration by homologous hormone. Effect of human growth hormone on its receptor in IM-9 lymphocytes. (1976) (313)
- Quantitative aspects of the insulin-receptor interaction in liver plasma membranes. (1974) (307)
- Evolutionary origins of vertebrate hormones: substances similar to mammalian insulins are native to unicellular eukaryotes. (1980) (284)
- MD-2 is required for disulfide HMGB1–dependent TLR4 signaling (2015) (267)
- Characteristics of the human lymphocyte insulin receptor. (1973) (265)
- Receptors for insulin-like growth factors I and II: autoradiographic localization in rat brain and comparison to receptors for insulin. (1988) (261)
- Peptide hormone binding to receptors: a review of direct studies in vitro. (1973) (258)
- The obesity pandemic: where have we been and where are we going? (2004) (255)
- ACTH receptors in the adrenal: specific binding of ACTH-125I and its relation to adenyl cyclase. (1970) (251)
- Insulin receptor deficiency in genetic and acquired obesity. (1975) (247)
- Defect in insulin binding to receptors in obese man. Amelioration with calorie restriction. (1975) (234)
- The evolutionary origins of hormones, neurotransmitters, and other extracellular chemical messengers: implications for mammalian biology. (1982) (222)
- PLASMA INSULIN AND GROWTH HORMONE LEVELS IN OBESITY AND DIABETES (1965) (219)
- Insulin receptors in human circulating cells and fibroblasts. (1972) (215)
- Receptors, antireceptor antibodies and mechanisms of insulin resistance. (1979) (210)
- Characterization of antibodies to the insulin receptor: a cause of insulin-resistant diabetes in man. (1976) (196)
- Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin (1978) (189)
- Binding of 125I-human growth hormone to specific receptors in human cultured lymphocytes. Characterization of the interaction and a sensitive radioreceptor assay. (1974) (182)
- Extreme insulin resistance in ataxia telangiectasia: defect in affinity of insulin receptors. (1978) (181)
- Control of blood glucose and diabetic vascular disease. (1977) (180)
- Five mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance. (1990) (178)
- Diet-induced improvement of abnormalities in insulin and glucagon secretion and in insulin receptor binding in diabetes mellitus. (1979) (168)
- Receptors for insulin, NSILA-s, and growth hormone: applications to disease states in man. (1975) (168)
- The insulin receptor in vertebrates is functionally more conserved during evolution than insulin itself. (1979) (155)
- Tumors, IGF-2, and hypoglycemia: insights from the clinic, the laboratory, and the historical archive. (2013) (152)
- Characterization of insulin-mediated phosphorylation of the insulin receptor in a cell-free system. (1983) (151)
- Methods for assessing immunologic and biologic properties of iodinated peptide hormones. (1975) (150)
- Increased insulin binding to erythrocytes in anorexia nervosa: restoration to normal with refeeding. (1979) (150)
- BINDING OF HORMONE TO TISSUE: THE FIRST STEP IN POLYPEPTIDE HORMONE ACTION (1966) (150)
- Corticotropin and β-endorphin-like materials are native to unicellular organisms (1982) (149)
- Hypoglycemia in association with extrapancreatic tumors: demonstration of elevated plasma NSILA-s by a new radioreceptor assay. (1974) (147)
- Radioreceptor Assay of Adrenocorticotropic Hormone: New Approach to Assay of Polypeptide Hormones in Plasma (1970) (144)
- Impairment of insulin binding to the fat cell plasma membrane in the obese hyperglycemic mouse (1972) (141)
- Insulin resistance associated with androgen excess in women with autoantibodies to the insulin receptor. (1982) (140)
- The insulin resistance of acromegaly: evidence for two alterations in the insulin receptor on circulating monocytes. (1979) (139)
- Insulin is ubiquitous in extrapancreatic tissues of rats and humans. (1980) (137)
- Effects of Calcium on ACTH Stimulation of the Adrenal: Separation of Hormone Binding from Adenyl Cyclase Activation (1970) (135)
- Studies on binding and mitogenic effect of insulin and insulin-like growth factor I in glomerular mesangial cells. (1988) (133)
- Glucagon-like peptide-1(7-36) amide (GLP-1) enhances insulin-stimulated glucose metabolism in 3T3-L1 adipocytes: one of several potential extrapancreatic sites of GLP-1 action. (1994) (132)
- Insulin receptors in human circulating lymphocytes: application to the study of insulin resistance in man. (1973) (129)
- Insulin is present in chicken eggs and early chick embryos. (1982) (128)
- Basal-State Hyperinsulinemia in Healthy Normoglycemic Adults Is Predictive of Type 2 Diabetes Over a 24-Year Follow-Up (2009) (125)
- Insulin and insulin-like growth factor I in early development: peptides, receptors and biological events. (1990) (125)
- Direct demonstration of glycosylation of insulin receptor subunits by biosynthetic and external labeling: evidence for heterogeneity. (1981) (122)
- Ontogeny of receptors for insulin-like peptides in chick embryo tissues: early dominance of insulin-like growth factor over insulin receptors in brain. (1985) (121)
- Glucagon receptors in -cells. Binding of 125 I-glucagon and activation of adenylate cyclase. (1972) (117)
- Migraine and obesity: epidemiology, possible mechanisms and the potential role of weight loss treatment (2011) (116)
- The NSILA-s receptor in liver plasma membranes. Characterization and comparison with the insulin receptor. (1975) (113)
- The evolving clinical course of patients with insulin receptor autoantibodies: spontaneous remission or receptor proliferation with hypoglycemia. (1978) (112)
- Decreased insulin binding in cultured lymphocytes from two patients with extreme insulin resistance. (1982) (109)
- Insulin-induced loss of the insulin receptor in IM-9 lymphocytes. A biological process mediated through the insulin receptor. (1980) (106)
- Regulation of insulin receptors and insulin responsiveness in 3T3-L1 fatty fibroblasts. (1979) (105)
- Insulin resistance, acanthosis nigricans, and normal insulin receptors in a young woman: evidence for a postreceptor defect. (1978) (102)
- Insulin receptors in normal and transformed fibroblasts: relationship to growth and transformation (1976) (101)
- Glucose intolerance in cystic fibrosis. (1969) (101)
- Genetic and environmental interactions in obesity and type 2 diabetes. (2008) (100)
- Are messenger molecules in microbes the ancestors of the vertebrate hormones and tissue factors? (1983) (98)
- The insulin receptor of rat brain is coupled to tyrosine kinase activity. (1984) (97)
- Insulin in Insects and Annelids (1981) (97)
- Galantamine Alleviates Inflammation and Other Obesity-Associated Complications in High-Fat Diet-Fed Mice (2011) (96)
- Unique Features of the Insulin Receptor in Rat Brain (1984) (96)
- Thymic lymphocytes in obese (ob-ob) mice. A mirror of the insulin receptor defect in liver and fat. (1974) (95)
- Hypoglycemia associated with non-islet-cell tumor and insulin-like growth factors. (1981) (95)
- Insulin and non-suppressible insulin-like activity (NSILA-s): evidence for separate plasma membrane receptor sites. (1974) (93)
- Decreased binding of insulin to its receptors in rats with hormone induced insulin resistance. (1973) (92)
- Glucagon-like peptide-1 affects gene transcription and messenger ribonucleic acid stability of components of the insulin secretory system in RIN 1046-38 cells. (1995) (92)
- Regulation of insulin receptors in normal and abnormal physiology in humans. (1979) (91)
- Studies on the adrenocorticotropic hormone-activated adenyl cyclase of a functional adrenal tumor. (1969) (91)
- Immunoprecipitation of the insulin receptor: a sensitive assay for receptor antibodies and a specific technique for receptor purification. (1979) (90)
- Insulin receptor defect in insulin resistance: studies in the obese-hyperglycimic mouse. (1972) (89)
- GLP-1 action in L6 myotubes is via a receptor different from the pancreatic GLP-1 receptor. (1998) (89)
- Avoiding iatrogenic harm to patient and family while discussing goals of care near the end of life. (2006) (88)
- Novel signal transduction and peptide specificity of glucagon‐like peptide receptor in 3T3‐L1 adipocytes (1997) (88)
- ACTH‐RECEPTOR INTERACTION IN THE ADRENAL: A MODEL FOR THE INITIAL STEP IN THE ACTION OF HORMONES THAT STIMULATE ADENYL CYCLASE (1971) (87)
- Specificity spillover at the hormone receptor--exploring its role in human disease. (1989) (85)
- Radiohistochemical localization of insulin receptors in the adult and developing rat brain (1980) (85)
- Insulin and insulin receptors in rodent brain (1981) (83)
- The role of antireceptor antibodies in stimulating phosphorylation of the insulin receptor. (1984) (82)
- Circulating NSILA-s in man: Preliminary studies of stimuli in vivo and of binding to plasma components. (1975) (81)
- Water-Soluble Insulin Receptors from Human Lymphocytes (1972) (79)
- Diabetes and obesity. (1997) (79)
- Qualitative abnormalities in insulin binding in a patient with extreme insulin resistance: decreased sensitivity to alterations in temperature and pH. (1981) (78)
- Proinsulin-like component of circulating insulin in the basal state and in patients and hamsters with islet cell tumors. (1971) (78)
- Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes. (2016) (78)
- Glucose utilization in a patient with hepatoma and hypoglycemia. Assessment by a positron emission tomography. (1992) (77)
- Genes encoding receptors for insulin and insulin-like growth factor I are expressed in Xenopus oocytes and embryos. (1991) (76)
- Demonstration of the insulin receptor in vivo in rabbits and its possible role as a reservoir for the plasma hormone. (1978) (76)
- Immunoassay of plasma vasopressin in man. (1970) (75)
- Insulin stimulated phosphorylation of its own receptor. Activation of a tyrosine-specific protein kinase that is tightly associated with the receptor. (1983) (74)
- HMGB1 mediates splenomegaly and expansion of splenic CD11b+ Ly-6Chigh inflammatory monocytes in murine sepsis survivors (2013) (72)
- Transport to cell surface of intestinal sucrase-isomaltase is blocked in the Golgi apparatus in a patient with congenital sucrase-isomaltase deficiency. (1985) (72)
- Developmental Regulation of Insulin and Type I Insulin-Like Growth Factor Receptors and Absence of Type II Receptors in Chicken Embryo Tissues (1988) (71)
- Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men. (1997) (69)
- Autoantibodies to the insulin receptor. Effect on the insulin-receptor interaction in IM-9 lymphocytes. (1977) (67)
- Change in affinity of insulin receptors following oral glucose in normal adults. (1977) (67)
- Insulin-induced dissociation of its receptor into subunits: possible molecular concomitant of negative cooperativity. (1976) (66)
- Plasma insulin: fluctuations in the "big" insulin component in man after glucose and other stimuli. (1969) (66)
- Insulin receptor status in disease states of man. (1977) (66)
- Post-sepsis syndrome – an evolving entity that afflicts survivors of sepsis (2019) (65)
- Insulin Antibodies Retard and Insulin Accelerates Growth and Differentiation in Early Embryos (1985) (64)
- Insulin receptors in patients with insulinomas: changes in receptor affinity and concentration. (1977) (64)
- Decreased insulin binding to cultured cells from a patient with the Rabson-Mendenhall syndrome: dichotomy between studies with cultured lymphocytes and cultured fibroblasts. (1983) (64)
- Insulin in brain and other extrapancreatic tissues of vertebrates and nonvertebrates. (1983) (60)
- Inhibition of Cyclic 3′,5′-AMP Phosphodiesterase in Islet Cells and Other Tissues by Tolbutamide (1971) (59)
- Is metformin poised for a second career as an antimicrobial? (2018) (59)
- Studies of plasma insulin in myotonic dystrophy. (1969) (59)
- Galantamine alleviates inflammation and insulin resistance in patients with metabolic syndrome in a randomized trial. (2017) (58)
- Direct method for detection and characterization of cell surface receptors for insulin by means of 125I-labeled autoantibodies against the insulin receptor. (1976) (58)
- Petition to replace current OGTT criteria for diagnosing prediabetes with the 1-hour post-load plasma glucose ≥ 155 mg/dl (8.6 mmol/L). (2018) (58)
- One‐hour post‐load plasma glucose level during the OGTT predicts mortality: observations from the Israel Study of Glucose Intolerance, Obesity and Hypertension (2016) (57)
- The insulin receptor of the turkey erythrocyte: similarity to mammalian insulin receptors. (1977) (56)
- Extreme insulin resistance in association with abnormally high binding affinity of insulin receptors from a patient with leprechaunism: evidence for a defect intrinsic to the receptor. (1982) (55)
- The Insulin Receptor and Insulin of the Atlantic Hagfish: Extraordinary Conservation of Binding Specificity and Negative Cooperativity in the Most Primitive Vertebrate (1979) (55)
- Cell surface receptors for insulin and human growth hormone. Effect of microtubule and microfilament modifiers. (1976) (54)
- "Big" Growth Hormone Components from Human Plasma: Decreased Reactivity Demonstrated by Radioreceptor Assay (1973) (53)
- 18F-labeled insulin: a prosthetic group methodology for incorporation of a positron emitter into peptides and proteins. (1989) (52)
- Elevated 1-hour plasma glucose levels are associated with dysglycemia, impaired beta-cell function, and insulin sensitivity: a pilot study from a real world health care setting (2016) (50)
- Binding and degradation of insulin by human peripheral granulocytes. Demonstration of specific receptors with high affinity. (1976) (50)
- Inappropriate vasopressin secretion and carcinoma of the pancreas. (1968) (49)
- Two nonallelic insulin genes in Xenopus laevis are expressed differentially during neurulation in prepancreatic embryos. (1991) (49)
- Diabetes insipidus: celebrating a century of vasopressin therapy. (2014) (49)
- Insulin's discovery: New insights on its ninetieth birthday (2012) (47)
- One-hour post-load plasma glucose level during the OGTT predicts dysglycemia: Observations from the 24year follow-up of the Israel Study of Glucose Intolerance, Obesity and Hypertension. (2016) (47)
- Incretin hormones regulate glucose-dependent insulin secretion in RIN 1046-38 cells: mechanisms of action. (1994) (46)
- GLP-1 action in L6 myotubes is via a receptor different from the pancreatic GLP-1 receptor. (1998) (46)
- The amino acid sequence of the insulin receptor is normal in an insulin-resistant Pima Indian. (1990) (46)
- Detection of Mutations in Insulin Receptor Gene by Denaturing Gradient Gel Electrophoresis (1992) (45)
- Genes for the insulin receptor and the insulin-like growth factor I receptor are expressed in the chicken embryo blastoderm and throughout organogenesis. (1991) (45)
- TRP64ARG β3-adrenergic receptor and obesity in Mexican Americans (1997) (45)
- Development of receptors for insulin and insulin-like growth factor-I in head and brain of chick embryos: autoradiographic localization. (1989) (44)
- A synthetic tris-sulfotyrosyl dodecapeptide analogue of the insulin receptor 1146-kinase domain inhibits tyrosine dephosphorylation of the insulin receptor in situ. (1994) (44)
- An Introduction to Receptors and Receptor Disorders (1979) (44)
- Insulin stimulates phosphorylation of serine residues in soluble insulin receptors. (1983) (43)
- The insulin receptor of the turkey erythrocyte. Characterization of the membrane-bound receptor. (1976) (43)
- The insulin receptors of chick embryo show tissue-specific structural differences which parallel those of the insulin-like growth factor I receptors. (1987) (43)
- Radioimmunoassay of the insulin receptor: a new probe of receptor structure and function. (1979) (42)
- Berson, Yalow, and the JCI: the agony and the ecstasy. (2004) (42)
- Insulin-induced receptor loss in the cultured human lymphocyte: quantitative morphological perturbations in the cell and plasma membrane. (1979) (42)
- Fasting and refeeding alter the insulin receptor tyrosine kinase in chicken liver but fail to affect brain insulin receptors. (1986) (42)
- Xenopus laevis contains two nonallelic preproinsulin genes. cDNA cloning and evolutionary perspective. (1989) (42)
- The 1-hour post-load glucose level is more effective than HbA1c for screening dysglycemia (2016) (40)
- Energy, evolution, and human diseases: an overview. (2011) (39)
- Basal state hyperinsulinemia in healthy normoglycemic adults heralds dysglycemia after more than two decades of follow up (2012) (39)
- Isolation and characterization of two different insulins from an amphibian, Xenopus laevis. (1989) (38)
- Insulin receptor degradation is accelerated in cultured lymphocytes from patients with genetic syndromes of extreme insulin resistance. (1984) (38)
- Hormonal regulation of human growth. (1987) (38)
- Protein kinase activity of the insulin receptor in human circulating and cultured mononuclear cells. (1983) (38)
- Obesity Paradox, Obesity Orthodox, and the Metabolic Syndrome: An Approach to Unity (2016) (38)
- Characterization of insulin receptors in patients with the syndromes of insulin resistance and acanthosis nigricans (1980) (38)
- Endocrinization of the early embryo: an emerging role for hormones and hormone-like factors. (1990) (36)
- Cell membrane receptors for polypeptide hormones. Application to the study of disease states in mice, and men. (1975) (36)
- Kinetic Modeling of Insulin Binding to Receptors and Degradation In Vivo in the Rabbit (1980) (35)
- Insulin response to glucose is lower in individuals homozygous for the Arg 64 variant of the beta-3-adrenergic receptor. (2000) (35)
- Relationship between impact strength and spherulite growth in linear polyethylene (1959) (35)
- Beneficial effect of the insulin sensitizer (HSP inducer) BGP-15 on olanzapine-induced metabolic disorders (2010) (34)
- Insulin-like growth factor I activity is stored in the yolk of the avian egg. (1989) (34)
- Globin Attenuates the Innate Immune Response to Endotoxin (2002) (34)
- Radioreceptor assay of insulin: Comparison of plasma and pancreatic insulins and proinsulins. (1975) (33)
- Evolutionary origins of neuropeptides, hormones, and receptors: possible applications to immunology. (1985) (33)
- Monoiodo-oxytocin: Demonstration of Its Biological Activity and Specific Binding to Isolated Fat Cells (1972) (32)
- Dynamic regulation of intact and C-terminal truncated insulin receptor phosphorylation in permeabilized cells. (1994) (32)
- β3-adrenoceptor gene variant in obesity and insulin resistance (1996) (32)
- The underlying insulin receptor in patients with antireceptor autoantibodies: demonstration of normal binding and immunological properties. (1979) (31)
- Evidence that Xenopus laevis contains two different nonallelic insulin-like growth factor-I genes. (1990) (31)
- Circulating proinsulin-like component in man: Increased proportion in hypoinsulinemic states (1974) (31)
- Preparation of solubilized insulin receptors from human lymphocytes. (1972) (30)
- Brain glucose metabolism in noninsulin-dependent diabetes mellitus: a study in Pima Indians using positron emission tomography during hyperinsulinemia with euglycemic glucose clamp. (1990) (30)
- Insulin receptors in brain. (1983) (30)
- Rapid effects of insulin on cyclic GMP location in an intact protozoan (1992) (30)
- Early development and tissue-specific patterns of insulin binding in chick embryo. (1984) (29)
- Circulating insulin: the proinsulin-like properties of “big” insulin in patients without islet cell tumors (1971) (29)
- Prolactin stimulation by thyrotropin-releasing hormone in a patient with isolated thyrotropin deficiency. (1972) (29)
- Effect of propranolol and phentolamine on canine and bovine responses to TSH. (1969) (28)
- Lessons learned from the 1‐hour post‐load glucose level during OGTT: Current screening recommendations for dysglycaemia should be revised (2018) (28)
- Transgenic hyperinsulinemia: A mouse model of insulin resistance and glucose intolerance without obesity (1996) (27)
- Molecules of intercellular communication in vertebrates, invertebrates and microbes: do they share common origins? (1986) (27)
- Insulin-stimulated receptor phosphorylation appears normal in cultured Epstein-Barr virus-transformed lymphocyte cell lines derived from patients with extreme insulin resistance. (1985) (25)
- Two mutations in a conserved structural motif in the insulin receptor inhibit normal folding and intracellular transport of the receptor. (1994) (25)
- Properties and partial purification of the detergent-solubilized insulin receptor: a demonstration of negative cooperativity in micellar solution. (1978) (25)
- Insulin-related materials in the nervous system of vertebrates and non-vertebrates: possible extrapancreatic production. (1988) (25)
- The brighter (and evolutionarily older) face of the metabolic syndrome: evidence from Trypanosoma cruzi infection in CD‐1 mice (2015) (25)
- Insulin receptors in brain and other tissues: similarities and differences (1988) (24)
- Corticotropin and beta-endorphin-like materials are native to unicellular organisms. (1982) (24)
- Receptors for peptide hormones: alterations in diseases of humans. (1982) (24)
- Neuronal Circuits Modulate Antigen Flow Through Lymph Nodes (2015) (22)
- Ontogeny, circadian rhythm pattern, and hormonal modulation of 5 alpha-dihydrotestosterone receptors in the rat pineal. (1993) (22)
- Identification and high yield purification of insulin-like growth factors (nonsuppressible insulin-like activities and somatomedins) from human plasma by use of endogenous binding proteins. (1979) (22)
- Evolutionary speculation about tuberculosis and the metabolic and inflammatory processes of obesity. (2009) (22)
- TRP64ARG beta 3-adrenergic receptor and obesity in Mexican Americans. (1997) (22)
- Insulin and insulin receptors in rodent brain. (1981) (22)
- Insulin-stimulated phosphorylation of the insulin receptor precursor. (1983) (21)
- Hormonal regulation of the affinity and concentration of hormone receptors in target cells. (1976) (21)
- Receptors for intercellular messenger molecules in microbes: similarities to vertebrate receptors and possible implications for diseases in man. (1986) (19)
- Sequestering HMGB1 via DNA-Conjugated Beads Ameliorates Murine Colitis (2014) (18)
- Dysglycemia and long‐term mortality: observations from the Israel study of glucose intolerance, obesity and hypertension (2015) (18)
- Evolutionary origins of vertebrate hormones: material very similar to adrenocorticotropic hormone, beta-endorphin, and dynorphin in protozoa. (1981) (18)
- In Vivo Imaging of Insulin Receptors in Monkeys Using 18F-Labeled Insulin and Positron Emission Tomography (1992) (18)
- [4] Assay of peptide hormones using cell receptors: Application to insulin and to human growth hormone (1975) (18)
- The insulin-stimulated receptor kinase is a tyrosine-specific casein kinase. (1983) (18)
- Reuniting overnutrition and undernutrition, macronutrients, and micronutrients (2018) (17)
- Effect of altered nutritional states on insulin receptors. (1988) (17)
- Insulin immunoreactive sites demonstrated in the Golgi apparatus of pancreatic B cells. (1981) (17)
- Effects of chronic glucocorticoid excess in man on insulin binding to circulating cells: differences between endogenous and exogenous hypercorticism. (1983) (16)
- Insulin Binding to Its Receptor: Is the Receptor More Important Than the Hormone? (1981) (16)
- Immunoprecipitation of insulin receptors from cultured human lymphocytes (IM-9 cells) by antibodies to pp60src. (1985) (15)
- The influence of plasma insulin concentrations on tissue insulin levels in rodents: a study of the diabetic Chinese hamster and the ob/ob mouse. (1986) (15)
- Can ‘personalized diagnostics’ promote earlier intervention for dysglycaemia? Hypothesis ready for testing (2010) (14)
- The immunology of the insulin receptor. (1976) (14)
- Nonsuppressible insulin-like activity of human serum. A potent inhibitor of insulin degradation. (1976) (14)
- Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes. (2016) (13)
- More recent, better designed studies have weakened links between antidiabetes medications and cancer risk (2019) (13)
- Ghrelin as an Anti-Sepsis Peptide: Review (2021) (12)
- Two distinct insulins in the guinea pig: the broad relevance of these findings to evolution of peptide hormones. (1983) (12)
- Inhibition of insulin receptor binding by dimethyl sulfoxide. (1979) (12)
- Tumor Hypoglycemia Linked to IGF-II (1999) (12)
- Insulin and Insulin Receptors in the Nervous System of Mammals (1981) (12)
- Sex and ethnic‐origin specific BMI cut points improve prediction of 40‐year mortality: the Israel GOH study (2015) (12)
- A novel chicken homeobox-containing gene expressed in neurulating embryos. (1993) (12)
- The metabolic deterioration that antedates diabetes: personal trajectories of HbA1c and fasting glucose as early indicators and possible triggers for intervention (2013) (12)
- Extracts of protozoa contain materials that react specifically in the immunoassay for guinea pig insulin. (1986) (11)
- Characterization of an endogenous substrate related to insulin and insulin-like growth factor-I receptors in lizard brain. (1987) (10)
- Reducing the prevalence of dysglycemia: is the time ripe to test the effectiveness of intervention in high-risk individuals with elevated 1 h post-load glucose levels? (2017) (10)
- EFFECTS OF STARVATION, REFEEDING, AND DIETING (1976) (9)
- Hormone resistance and hormone sensitivity. (1977) (9)
- Xenopus laevis oocytes, eggs and tadpoles contain immunoactive insulin. (1994) (9)
- Receptors for intercellular messenger molecules in microbes: Similarities to vertebrate receptors and possible implications for diseases in man (1986) (9)
- Alterations in pancreatic β cell function and Trypanosoma cruzi infection: evidence from human and animal studies (2017) (7)
- Beta 3-adrenoceptor gene variant in obesity and insulin resistance. (1996) (7)
- Diabetes, glucose control, glucose lowering medications, and cancer risk: A 10-year population-based historical cohort (2012) (7)
- Widening awareness of hyperglycemia unawareness (2000) (7)
- Assay of peptide hormones using cell receptors: application to insulin and to human growth hormone. (1975) (7)
- Downregulation Occurs Normally in Cultured Epstein-Barr Virus-transformed Lymphocytes from Patients with Extreme Insulin Resistance: Discrepancy Between Downregulation In Vivo and In Vitro (1984) (7)
- Autoantibodies to the insulin receptor activate glycogen synthase in rat adipocytes (1978) (6)
- REGULATION OF INSULIN AND GROWTH HORMONE RECEPTORS IN VITRO AND IN VIVO (1978) (6)
- Addressing food insecurity: freedom from want, freedom from fear. (2010) (5)
- Newly diagnosed type 2 diabetes may serve as a potential marker for pancreatic cancer (2018) (5)
- Receptors for Insulin and Insulin Related Peptides in the CNS: Studies of Localization in Rat Brain (1987) (5)
- Insulin-related material extractable from brain and other tissues of rat: Possible biologic and methodologic variables (1990) (5)
- Increased 125I-Insulin Receptor Binding to Erythrocytes of Hypoglycemic Infants and Children (1981) (5)
- You shall know the truth and the truth shall set you free (1999) (4)
- A tribute to Rosalyn S. Yalow. (2011) (4)
- Growth Hormone Releasing Hormone (GHRH) Effects in Healthy Aging Men (1996) (4)
- Years of potential life lost in pre-diabetes and diabetes mellitus: data from a 40-year follow-up of the Israel study on Glucose intolerance, Obesity and Hypertension (2021) (4)
- The Personalized Approach for Detecting Prediabetes and Diabetes. (2015) (4)
- Receptors: Birth, Eclipse, and Rediscovery (1988) (4)
- Rosalyn Sussman Yalow (1921–2011) (2012) (4)
- The Insulin Receptor and its Function (1981) (3)
- Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes. (2018) (3)
- Subpopulations of antibodies directed against evolutionarily conserved regions of the insulin molecule in insulin-treated patients (1982) (3)
- Circulating insulin: th proinsulin-like properties of "big" insulin in patients withou islet cell tumors. (1971) (2)
- A Tribute to Rachmiel Levine: 1910–1998 (1998) (2)
- Emetine Di-HCl Attenuates Type 1 Diabetes Mellitus in Mice (2016) (2)
- Syndromes associated with inappropriate hormone synthesis by tumors: an evolutionary interpretation. (1985) (2)
- Two distinct insulin-related molecules in the guinea pig: immunological and biochemical characterization of insulin-like immunoactivity from extrapancreatic tissues of the guinea pig (1985) (2)
- Solomon A. Berson (1973) (2)
- Human Chorionic Gonadotropin and Related Peptides: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis (2021) (2)
- Insulin resistant syndromes in humans. (1979) (2)
- Paradigm shifts in obesity research and treatment: roundtable discussion. (2004) (2)
- Synthesis of enkephalin-based affinity labels for delta opioid receptors (1994) (1)
- HEMOGLOBIN ENHANCES MIF-AND INTERLEUKIN-1-MEDIATED TNF RELEASE IN MURINE MACROPHAGE-LIKE RAW 264.7 CELLS (1999) (1)
- Oxytocin and Related Peptide Hormones: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis (2022) (1)
- Insulin Receptors in Disorders of Glucose Tolerance and Insulin Sensitivity (1981) (1)
- INSULIN IN THE BRAIN AND OTHER EXTRAPANCREATIC TISSUES (1981) (1)
- Goldberger’s war:The life and work of a public health crusader. (2004) (1)
- Spectre of Noah (2004) (1)
- Insulin reverses the growth retardation effect of phorbol ester in chicken embryos during organogenesis. (1989) (1)
- Diabetes, glucose control, glucose lowering medications, and cancer risk: A 10-year population-based historical cohort (2012) (1)
- Receptors for Insulin and Insulin-Like Growth Factors I and II in PCD Mice and Diabetic Rats are Unaltered: An Autoradiographic Study (1989) (1)
- Insulin-induced Loss of the Insulin Receptor in I ” 9 Lymphocytes (2001) (1)
- Voices: Insulin and beyond. (2021) (1)
- Hormones and other Messenger Molecules: An Approach to Unity (1984) (1)
- Embryonic chicken lens cells cultured in reconstituted basement membrane: an experimental model to maintain the epithelial phenotype in culture. (1991) (1)
- Post-translational modifications of the insulin receptor. (1988) (1)
- Monoido-oxytocin: demonstration of its biological activity and specific binding to isolated fat cells. (1972) (1)
- Corticotropin and f3-endorphin-likc unicellular organisms (2016) (0)
- Progress in therapy: the delicate balance (2008) (0)
- Galantamine Treatment as a Novel Therapeutic Approach in Alleviating Obesity and Obesity-Related Complications in High-Fat Diet-Fed Mice: 287 (2010) (0)
- ANTIBODIES TO INSULIN RECEPTORS: PROBES OF RECEPTOR STRUCTURE AND FUNCTION (1978) (0)
- In Search of Jewish Women: My Travels into Light (2021) (0)
- Energy , evolution , and human diseases : an overview 1 – 4 (2011) (0)
- Abstracts (1969) (0)
- RESULTS Galantamine Reduces Body Weight Gain , Food Intake and Abdominal Adiposity in High-Fat Diet – Fed Mice (2011) (0)
- Eugene Whitehorn Straus, MD (2011) (0)
- The Nobel prizes (3): Physiology and Medicine: Starting a revolution (1977) (0)
- for disulfide HMGB1– dependent TLR4 signaling (2015) (0)
- Thymic Lymphocytes in Obese ( ob / ob ) Mice (2002) (0)
- Inappropriate Antidiuretic Hormone Syndrome and Carcinoma of Pancreas with Demonstration of Tumor Antidiuretic Activity. (1968) (0)
- Cholinergic activation by galantamine suppresses obesity-associated inflammation in mice (54.4) (2011) (0)
- Diabetes/Metabolism Reviews becomes Diabetes/Metabolism Research and Reviews (1999) (0)
- Positron emission tomographic (PET) imaging of a peptide receptor in vivo using a general prosthetic group methodology: 18F-labeled insulin (1990) (0)
- Treatment with Growth Hormone: Focus on Specificity with a View to the Future (1995) (0)
- Biomedical meetings and biomedical journals: Vive la difference et vive la compagnie (2010) (0)
- sensitive tissue must be binding of the hormone to some cellular constituent. To delineate this interaction we have studied the effects of thyroid-stimulating hor- mone (TSH) on thyroid slices and of insulin on skeletal muscle. Tissues that were (2016) (0)
- Editors' note to Raz and Eldor's commentary “Rational therapy for diabetes: early recognition of adverse effects and avoidance of disruptive false alarms”. Diabetes Metab Res Rev 2012 (2012) (0)
- Insulin and insulin receptors in early chick embryo development (1986) (0)
- Alterations in pancreatic β cell function and Trypanosoma cruzi infection: evidence from human and animal studies (2016) (0)
- A piece of my mind. Spectre of Noah: "tell me a story!". (2004) (0)
- Urgent call for the third wish (2013) (0)
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