Julian Blow

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Julian Blow is affiliated with the following schools: University of Oxford, University of Dundee

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Julian Blow

Biology

#9967

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#13240

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Molecular Biology

#1579

World Rank

#1607

Historical Rank

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Biology

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According to Wikipedia, Julian Blow is a molecular biologist, Professor of Chromosome Maintenance, and Dean of the School of Life Sciences, University of Dundee, Scotland. Education and career Blow graduated with a BSc in Medical Sciences from the University of Edinburgh in 1984. He then earned his PhD in DNA replication from the University of Cambridge in 1987. Following his PhD, in 1988, he worked as a postdoctoral research fellow at the University of Oxford. In 1991 he established his own laboratory at the ICRF Clare Hall Laboratories before being promoted to Senior Scientist in 1996. The following year he moved to the University of Dundee as a Principal Investigator. In 2012 he became Director of the Centre for Gene Regulation and Expression. In 2014, he was made Director of Research for the School of Life Sciences and then, in 2016, he was appointed Dean of the School of Life Sciences.

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Julian Blow's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. (1997) (1321)
Preventing re-replication of chromosomal DNA (2005) (697)
Inhibition of cyclin-dependent kinases by purine analogues. (1994) (591)
Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs (1986) (589)
A role for the nuclear envelope in controlling DNA replication within the cell cycle (1988) (584)
Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress. (2007) (520)
Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates. (1991) (502)
Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin (2001) (488)
Translation of cyclin mRNA is necessary for extracts of activated Xenopus eggs to enter mitosis (1989) (410)
Purification of an MCM-containing complex as a component of the DNA replication licensing system (1995) (372)
S phase of the cell cycle. (1989) (364)
Excess Mcm2–7 license dormant origins of replication that can be used under conditions of replicative stress (2006) (362)
Interaction between the Origin Recognition Complex and the Replication Licensing Systemin Xenopus (1996) (271)
Steps in the assembly of replication-competent nuclei in a cell-free system from Xenopus eggs (1988) (230)
How dormant origins promote complete genome replication. (2011) (224)
The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin (1996) (219)
Replication licensing and cancer — a fatal entanglement? (2008) (215)
Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing (2016) (215)
Replication licensing — Origin licensing: defining the proliferative state? (2002) (210)
Preventing re-replication of DNA in a single cell cycle: evidence for a replication licensing factor (1993) (204)
Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories (2010) (199)
Changes in association of the Xenopus origin recognition complex with chromatin on licensing of replication origins. (1999) (198)
Live-Cell Imaging Reveals Replication of Individual Replicons in Eukaryotic Replication Factories (2006) (196)
Replication occurs at discrete foci spaced throughout nuclei replicating in vitro. (1989) (190)
Replication licensing--defining the proliferative state? (2002) (183)
Cell type-specific responses of human cells to inhibition of replication licensing (2002) (181)
The role of MCM/P1 proteins in the licensing of DNA replication. (1996) (179)
Regulating the licensing of DNA replication origins in metazoa. (2006) (177)
Xenopus cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading. (2000) (173)
Cell Cycle Regulation of the Replication Licensing System: Involvement of a Cdk-dependent Inhibitor (1997) (170)
Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re‐replication in Xenopus (2005) (167)
A cdc2-like protein is involved in the initiation of DNA replication in Xenopus egg extracts (1990) (166)
Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins (2001) (166)
Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision—repair (1994) (159)
Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts. (1996) (159)
Deregulated Replication Licensing Causes DNA Fragmentation Consistent with Head-to-Tail Fork Collision (2006) (152)
Replication Origins in XenopusEgg Extract Are 5–15 Kilobases Apart and Are Activated in Clusters That Fire at Different Times (2001) (152)
The role of cyclin synthesis, modification and destruction in the control of cell division (1989) (150)
ELYS/MEL-28 Chromatin Association Coordinates Nuclear Pore Complex Assembly and Replication Licensing (2007) (145)
MCM2-7 Form Double Hexamers at Licensed Origins in Xenopus Egg Extract* (2011) (144)
The RLF‐M component of the replication licensing system forms complexes containing all six MCM/P1 polypeptides (1997) (144)
Kinetochores Coordinate Pericentromeric Cohesion and Early DNA Replication by Cdc7-Dbf4 Kinase Recruitment (2013) (142)
Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinases (1994) (141)
DNA replication initiates at multiple sites on plasmid DNA in Xenopus egg extracts. (1992) (140)
The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation (2004) (131)
Sequential MCM/P1 Subcomplex Assembly Is Required to Form a Heterohexamer with Replication Licensing Activity* (2000) (121)
Dormant origins, the licensing checkpoint, and the response to replicative stresses. (2012) (118)
Nuclei act as independent and integrated units of replication in a Xenopus cell‐free DNA replication system. (1987) (116)
Mammalian nuclei become licensed for DNA replication during late telophase. (2002) (114)
Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability (2016) (108)
Geminin Becomes Activated as an Inhibitor of Cdt1/RLF-B Following Nuclear Import (2002) (104)
Replication of purified DNA in Xenopus egg extract is dependent on nuclear assembly. (1990) (100)
The contribution of dormant origins to genome stability: From cell biology to human genetics (2014) (99)
A model for DNA replication showing how dormant origins safeguard against replication fork failure (2009) (98)
Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in Xenopus (2004) (96)
The Cdc7/Dbf4 protein kinase: target of the S phase checkpoint? (2000) (96)
Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells (2016) (95)
Combinatorial Regulation of Meiotic Holliday Junction Resolution in C. elegans by HIM-6 (BLM) Helicase, SLX-4, and the SLX-1, MUS-81 and XPF-1 Nucleases (2013) (92)
Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template (2013) (92)
Control of chromosomal DNA replication in the early Xenopus embryo (2001) (91)
CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication. (2011) (91)
The regulation of replication origin activation. (1999) (89)
The dynamics of replication licensing in live Caenorhabditis elegans embryos (2012) (85)
Rapid induction of pluripotency genes after exposure of human somatic cells to mouse ES cell extracts. (2008) (83)
Characterization of the Xenopus replication licensing system. (1997) (83)
Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination (2004) (82)
Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1 (2017) (82)
Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing (2009) (79)
PHD1 Links Cell-Cycle Progression to Oxygen Sensing through Hydroxylation of the Centrosomal Protein Cep192 (2013) (77)
Chromatin proteins involved in the initiation of DNA replication. (1997) (75)
DNA replication licensing in somatic and germ cells (2004) (75)
Functional domains of the Xenopus replication licensing factor Cdt1 (2005) (73)
Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels (2010) (71)
Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation (2012) (71)
Preparation and use of Xenopus egg extracts to study DNA replication and chromatin associated proteins (2012) (68)
Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing (2018) (64)
Bod1, a novel kinetochore protein required for chromosome biorientation (2007) (63)
The chromosome cycle: coordinating replication and segregation (2005) (62)
Cell cycle control of replication initiation in eukaryotes. (1996) (61)
The requirement of yeast replication origins for pre-replication complex proteins is modulated by transcription (2005) (61)
The origin of CDK regulation (2001) (56)
Optimisation of the two-dimensional gel electrophoresis protocol using the Taguchi approach (2004) (49)
Replisome stall events have shaped the distribution of replication origins in the genomes of yeasts (2013) (46)
Nucleoplasmin-mediated chromatin remodelling is required for Xenopus sperm nuclei to become licensed for DNA replication. (2000) (44)
Stochastic association of neighboring replicons creates replication factories in budding yeast (2013) (44)
PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage. (2008) (41)
Interaction of Xenopus Cdc2·Cyclin A1 with the Origin Recognition Complex* (2000) (41)
The replication capacity of intact mammalian nuclei in Xenopus egg extracts declines with quiescence, but the residual DNA synthesis is independent of Xenopus MCM proteins. (2000) (39)
Temporal Profiling of the Chromatin Proteome Reveals System-wide Responses to Replication Inhibition (2008) (39)
The RLF-B component of the replication licensing system is distinct from Cdc6 and functions after Cdc6 binds to chromatin (1999) (38)
Buffered Qualitative Stability explains the robustness and evolvability of transcriptional networks (2014) (38)
Postural effects on intra-abdominal pressure during Valsalva maneuver. (1993) (37)
Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans (2014) (36)
Lgr5+ intestinal stem cells reside in an unlicensed G1 phase (2018) (36)
Clusters, factories and domains (2010) (34)
A Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replication (2004) (34)
The SMC-5/6 Complex and the HIM-6 (BLM) Helicase Synergistically Promote Meiotic Recombination Intermediate Processing and Chromosome Maturation during Caenorhabditis elegans Meiosis (2016) (33)
The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1 (2018) (32)
Both Chromosome Decondensation and Condensation Are Dependent on DNA Replication in C. elegans Embryos (2015) (32)
Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1 (2014) (31)
Inevitability and containment of replication errors for eukaryotic genome lengths spanning megabase to gigabase (2016) (30)
Chromosome replication in cell-free systems from Xenopus eggs. (1987) (30)
The replication licensing system. (1998) (30)
Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos (2012) (27)
The elusive determinants of replication origins (2007) (25)
Cell cycle: A new check on issuing the licence (2000) (24)
The Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication Licensing* (2013) (24)
The use of field emission in-lens scanning electron microscopy to study the steps of assembly of the nuclear envelope in vitro. (1992) (24)
Xenopus Mcm10 is a CDK-substrate required for replication fork stability (2016) (23)
The complex structure of S-phase comes into focus (2010) (22)
Mcm8 and Mcm9 form a dimeric complex in Xenopus laevis egg extract that is not essential for DNA replication initiation (2013) (22)
The DNA replication licensing system. (1997) (21)
Site-specific initiation of DNA replication in metazoan chromosomes and the role of nuclear organization. (1993) (20)
DNA replication licensing factor. (1996) (20)
The role of the replication licensing system in cell proliferation and cancer. (2003) (19)
A role for dormant origins in tumor suppression. (2011) (19)
The licensing checkpoint opens up (2009) (18)
Xenopus Cdc 7 function is dependent on licensing but not on XORC , XCdc 6 , or CDK activity and is required for XCdc 45 loading (18)
Xenopus cell-free extracts and their contribution to the study of DNA replication and other complex biological processes. (2016) (17)
Many strands converge (1987) (16)
Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins (2021) (16)
DNA replication: Stable driving prevents fatal smashes (2001) (16)
Optimal placement of origins for DNA replication. (2012) (15)
Histone acetylation by HBO1 tightens replication licensing. (2010) (15)
The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines (2017) (15)
Replication forks, chromatin loops and dormant replication origins (2008) (15)
Use of peptides from p21 (Waf1/Cip1) to investigate PCNA function in Xenopus egg extracts. (2001) (14)
Negative Regulation of Geminin by CDK-Dependent Ubiquitination Controls Replication Licensing (2004) (13)
Direct non transcriptional role of NF-Y in DNA replication. (2016) (13)
Nuclear structure and the control of DNA replication in the Xenopus embryo (1989) (13)
Second in the Cycles Review Series (2005) (12)
Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication. (2011) (12)
Eukaryotic chromosome replication requires both α and δ DNA polymerases (1989) (11)
Eukaryotic DNA replication (1996) (11)
Eukaryotic DNA replication reconstituted outside the cell (1988) (10)
PHD 1 Links Cell-Cycle Progression to Oxygen Sensing through Hydroxylation of the Centrosomal Protein Cep 192 (10)
The KRAB Zinc Finger Protein Roma/Zfp157 Is a Critical Regulator of Cell-Cycle Progression and Genomic Stability (2016) (9)
Cell Cycle Synchronization in Xenopus Egg Extracts. (2016) (9)
Saying a firm ‘no’ to DNA re-replication (1999) (7)
Evidence for a mammalian late-G1 phase inhibitor of replication licensing distinct from geminin or Cdk activity (2011) (6)
Defects in the origin licensing checkpoint stresses cells exiting G0 (2019) (6)
DNA replication and its control. (1989) (6)
The role of DDK and Treslin–MTBP in coordinating replication licensing and pre-initiation complex formation (2021) (5)
The regulation of chromosome replication (1992) (5)
A New Role for Ran in Ensuring Precise Duplication of Chromosomal DNA (2003) (5)
2005–2009 ASCB Annual Meeting abstracts (2011) (5)
DNA replication: many strands converge. (1987) (4)
Mitosis comes apart. (1989) (4)
Faculty Opinions recommendation of Integrative analysis of cell cycle control in budding yeast. (2004) (4)
Erratum: Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans (2015) (4)
Methyltransferases in foci (1993) (4)
Correction: Combinatorial Regulation of Meiotic Holliday Junction Resolution in C. elegans by HIM-6 (BLM) Helicase, SLX-4, and the SLX-1, MUS-81 and XPF-1 Nucleases (2013) (4)
Author Correction: Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans (2014) (3)
phosphatase 1 and is counteracted by checkpoint-regulated protein Cdc7 executes its essential function early in S phase Xenopus (2014) (3)
Cell cycle control of DNA replication by p34cdc2. (1991) (3)
16 Regulating Initiation Events in Metazoa (2006) (2)
Chromosome replication: from ORC to fork (2001) (2)
DDK: The Outsourced Kinase of Chromosome Maintenance (2022) (2)
Reversal of DDK-Mediated MCM Phosphorylation by Rif 1-PP 1 Regulates Replication Initiation and Replisome Stability Independently of ATR / Chk 1 Graphical (2017) (2)
University of Dundee Xenopus Cdc 7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1 (2013) (1)
DNA Replication Factor Cdt1 (2008) (1)
Protracted p53-independent stimulation of p21 fuels genomic instability by deregulating the replication licensing machinery (2016) (1)
Cell cycle: Degradation ensures integrity (2003) (1)
Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing (2018) (1)
Eukaryotic chromosome replication requires both alpha and delta DNA polymerases. (1989) (1)
The role of DDK and Treslin-MTBP in coordinating replication licensing and pre-Initiation Complex formation (2021) (1)
Chapter 2 DNA replication and its control (1996) (1)
A protein complex present at origins of DNA replication in yeast cells. (1992) (1)
Cell Multiplication - Editorial Overview (2000) (1)
Faculty Opinions recommendation of Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase. (2002) (0)
University of Dundee Both Chromosome Decondensation and Condensation Are Dependent on DNA Replication in C . elegans Embryos (2015) (0)
Both Chromosome Decon densation and Condensation Are Dependent on DNA Replication in C . elegans Embryos Graphical Abstract Highlights (2015) (0)
Stable driving prevents fatal smashes– DNA replication under control (2001) (0)
Chronic p53-independent p21 expression deregulates replication (2016) (0)
2. Introduction (0)
human cells to survive replicative stress 7 are required for - Dormant origins licensed by excess Mcm2 (2011) (0)
CHROMATIN PROTEOME DEMONSTRATES SYSTEM-WIDE RESPONSE TO REPLICATION INHIBITION (2008) (0)
Faculty Opinions recommendation of Isolating apparently pure libraries of replication origins from complex genomes. (2006) (0)
Rigaud and Schmincke Types of Lymphoepithelioma (2011) (0)
A probe for nascent DNA in intact nuclei (1987) (0)
Direct non transcriptional role of the CCAAT-factor NF-Y in DNA replication (2016) (0)
DNA replication. Methyltransferases in foci. (1993) (0)
rereplication of a gapped DNA template Deregulated origin licensing leads to chromosomal breaks by Material Supplemental (2013) (0)
Chapter 1:Conserved Steps in Eukaryotic DNA Replication (2009) (0)
The Involvement of cdc2 in Cell Cycle Control of DNA Replication in Xenopus Egg Extracts (1992) (0)
University of Dundee Histone H 4 K 20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing (2018) (0)
The chromatin proteome and a systems approach to understanding the cell cycle progression (2011) (0)
Eukary0tic chromosome replication requires both and 8 DNA p01ymerases (1989) (0)
Review of: "Determination of human DNA replication origin position and efficiency reveals principles of initiation zone organisation" (2022) (0)
Faculty Opinions recommendation of Differential subnuclear localization and replication timing of histone H3 lysine 9 methylation states. (2005) (0)
High levels of origin licensing during Xenopus cleavage divisions ensures complete and timely genome duplication (2021) (0)
Book reviews (1993) (0)
A non transcriptional role for NF-Y in DNA replication (2013) (0)
Delayed activation of the DNA replication licensing system in Lgr5(+) intestinal stem cells (2017) (0)
Part 1 of the license (1995) (0)
36 DNA Replication in Xenopus (1996) (0)

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What Schools Are Affiliated With Julian Blow?

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