Joachim Herz
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Computer Science
Joachim Herz's Degrees
- PhD Computer Science Stanford University
- Masters Computer Science University of California, Berkeley
- Bachelors Computer Science University of California, Berkeley
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(Suggest an Edit or Addition)Joachim Herz's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. (2006) (2253)
- Suppression of Aging in Mice by the Hormone Klotho (2005) (1618)
- Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. (1993) (1555)
- Reeler/Disabled-like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL Receptor and ApoE Receptor 2 (1999) (1253)
- Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP). (1994) (1197)
- LRP: a multifunctional scavenger and signaling receptor. (2001) (1000)
- An Endocytic Pathway Essential for Renal Uptake and Activation of the Steroid 25-(OH) Vitamin D3 (1999) (958)
- Direct Binding of Reelin to VLDL Receptor and ApoE Receptor 2 Induces Tyrosine Phosphorylation of Disabled-1 and Modulates Tau Phosphorylation (1999) (906)
- A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism. (1997) (865)
- Surface location and high affinity for calcium of a 500‐kd liver membrane protein closely related to the LDL‐receptor suggest a physiological role as lipoprotein receptor. (1988) (849)
- Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. (1994) (739)
- Essential functions of synapsins I and II in synaptic vesicle regulation (1995) (712)
- Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. (2012) (677)
- The LDL–receptor–related protein, LRP, is an apolipoprotein E-binding protein (1989) (661)
- Reelin and ApoE Receptors Cooperate to Enhance Hippocampal Synaptic Plasticity and Learning* (2002) (597)
- LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation (1992) (585)
- LRP: Role in Vascular Wall Integrity and Protection from Atherosclerosis (2003) (576)
- Interaction of Cytosolic Adaptor Proteins with Neuronal Apolipoprotein E Receptors and the Amyloid Precursor Protein* (1998) (560)
- 39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. (1991) (539)
- Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins. (1989) (530)
- Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. (1993) (525)
- Defective forebrain development in mice lacking gp330/megalin. (1996) (498)
- Reelin, lipoprotein receptors and synaptic plasticity (2006) (494)
- Interactions of the Low Density Lipoprotein Receptor Gene Family with Cytosolic Adaptor and Scaffold Proteins Suggest Diverse Biological Functions in Cellular Communication and Signal Transduction* (2000) (469)
- Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants. (1998) (463)
- Modulation of Synaptic Plasticity and Memory by Reelin Involves Differential Splicing of the Lipoprotein Receptor Apoer2 (2005) (453)
- The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins. (1994) (453)
- Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. (1997) (451)
- Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance. (1992) (435)
- Lipoprotein receptors in the nervous system. (2002) (422)
- Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes*♦ (2010) (408)
- Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein. (1990) (391)
- Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1 (2007) (354)
- Reelin Activates Src Family Tyrosine Kinases in Neurons (2003) (345)
- TDP-43 Is a Developmentally Regulated Protein Essential for Early Embryonic Development* (2009) (338)
- Homology of 54K protein of signal-recognition particle, docking protein and two E. coli proteins with putative GTPbinding domains (1989) (333)
- Short-term synaptic plasticity is altered in mice lacking synapsin I (1993) (319)
- Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist. (1994) (313)
- Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure (2002) (309)
- Mutations and addiction to EGFR: the Achilles 'heal' of lung cancers? (2004) (304)
- TDP-43 Is Directed to Stress Granules by Sorbitol, a Novel Physiological Osmotic and Oxidative Stressor (2010) (301)
- ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling (2010) (295)
- Reelin-mediated Signaling Locally Regulates Protein Kinase B/Akt and Glycogen Synthase Kinase 3β* (2002) (292)
- Reelin Modulates NMDA Receptor Activity in Cortical Neurons (2005) (285)
- Proteolytic Processing of Low Density Lipoprotein Receptor-related Protein Mediates Regulated Release of Its Intracellular Domain* (2002) (281)
- Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals. (1996) (272)
- RAP, a specialized chaperone, prevents ligand‐induced ER retention and degradation of LDL receptor‐related endocytic receptors. (1996) (268)
- Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo. (1995) (266)
- Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor. (1995) (257)
- Proteolytic processing of the 600 kd low density lipoprotein receptor‐related protein (LRP) occurs in a trans‐Golgi compartment. (1990) (256)
- Absence of P-selectin delays fatty streak formation in mice. (1997) (255)
- Disruption of Cholesterol 7α-Hydroxylase Gene in Mice (1996) (249)
- The Reelin Receptor ApoER2 Recruits JNK-interacting Proteins-1 and -2* (2000) (248)
- Apolipoprotein E Induces Antiinflammatory Phenotype in Macrophages (2011) (245)
- Reelin signaling directly affects radial glia morphology and biochemical maturation (2003) (241)
- The LDL Receptor Gene Family (Un)Expected Signal Transducers in the Brain (2001) (236)
- Disruption of cholesterol 7alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation. (1996) (232)
- Interaction of reelin signaling and Lis1 in brain development (2003) (229)
- Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. (1992) (226)
- Platelet-derived Growth Factor Mediates Tyrosine Phosphorylation of the Cytoplasmic Domain of the Low Density Lipoprotein Receptor-related Protein in Caveolae* (2002) (224)
- Apolipoprotein E receptors: linking brain development and alzheimer's disease (2000) (223)
- A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease (2017) (218)
- Apolipoprotein C-I modulates the interaction of apolipoprotein E with beta-migrating very low density lipoproteins (beta-VLDL) and inhibits binding of beta-VLDL to low density lipoprotein receptor-related protein. (1990) (217)
- Lipoprotein receptors: new roles for ancient proteins (1999) (217)
- Neuronal LRP1 Functionally Associates with Postsynaptic Proteins and Is Required for Normal Motor Function in Mice (2004) (210)
- Phosphatidylinositol 3-Kinase Interacts with the Adaptor Protein Dab1 in Response to Reelin Signaling and Is Required for Normal Cortical Lamination* (2003) (206)
- Adult Apaf-1-deficient mice exhibit male infertility. (2000) (201)
- Lrp4, a Novel Receptor for Dickkopf 1 and Sclerostin, Is Expressed by Osteoblasts and Regulates Bone Growth and Turnover In Vivo (2009) (194)
- Progranulin: A Proteolytically Processed Protein at the Crossroads of Inflammation and Neurodegeneration* (2012) (188)
- Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse. (1995) (188)
- TDP-43 aggregation in neurodegeneration: Are stress granules the key? (2012) (187)
- The Central Fragment of Reelin, Generated by Proteolytic Processing In Vivo, Is Critical to Its Function during Cortical Plate Development (2004) (186)
- Receptor Clustering Is Involved in Reelin Signaling (2004) (184)
- Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2. (2011) (183)
- Endocytic receptor LRP together with tPA and PAI‐1 coordinates Mac‐1‐dependent macrophage migration (2006) (175)
- The low-density lipoprotein receptor-related protein: double agent or decoy? (1991) (169)
- Standardizing Scavenger Receptor Nomenclature (2014) (165)
- Insulin-secreting β-Cell Dysfunction Induced by Human Lipoproteins* (2003) (165)
- Genetic deficiency in low density lipoprotein receptor-related protein confers cellular resistance to Pseudomonas exotoxin A. Evidence that this protein is required for uptake and degradation of multiple ligands. (1994) (164)
- Lrp4 Modulates Extracellular Integration of Cell Signaling Pathways in Development (2008) (162)
- Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice. (2007) (158)
- Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice. (1998) (157)
- Reelin Controls Neuronal Positioning by Promoting Cell-Matrix Adhesion via Inside-Out Activation of Integrin α5β1 (2012) (154)
- LRP4 mutations alter Wnt/beta-catenin signaling and cause limb and kidney malformations in Cenani-Lenz syndrome. (2010) (151)
- Sustained somatic gene inactivation by viral transfer of Cre recombinase (1996) (145)
- Conditional Expression of Mutant M-line Titins Results in Cardiomyopathy with Altered Sarcomere Structure* (2003) (143)
- Functions of lipoprotein receptors in neurons Published, JLR Papers in Press, December 1, 2003. DOI 10.1194/jlr.R300017-JLR200 (2004) (142)
- Essential roles for the FE65 amyloid precursor protein‐interacting proteins in brain development (2006) (139)
- Molecular mechanisms of lipoprotein receptor signalling (2005) (138)
- LDL-receptor structure: Calcium cages, acid baths and recycling receptors (1997) (138)
- The primary structure of the 70 kDa subunit of bovine soluble guanylate cyclase (1988) (137)
- Molecular dissection of ligand binding sites on the low density lipoprotein receptor-related protein. (1994) (136)
- Reelin signaling antagonizes β-amyloid at the synapse (2009) (132)
- Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice. (2005) (131)
- Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism (2018) (129)
- Differential Glycosylation Regulates Processing of Lipoprotein Receptors by γ-Secretase* (2003) (129)
- Cholesterol metabolism and embryogenesis. (1998) (129)
- γ-Secretase Limits the Inflammatory Response Through the Processing of LRP1 (2008) (128)
- Emerging topics in Reelin function (2010) (128)
- Proteomic Analysis of GLUT4 Storage Vesicles Reveals LRP1 to Be an Important Vesicle Component and Target of Insulin Signaling* (2009) (126)
- Elevated plasma factor VIII in a mouse model of low-density lipoprotein receptor-related protein deficiency. (2003) (124)
- Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexes. (2003) (121)
- Reelin and Cyclin-Dependent Kinase 5-Dependent Signals Cooperate in Regulating Neuronal Migration and Synaptic Transmission (2004) (119)
- LRP1 Functions as an Atheroprotective Integrator of TGFβ and PDGF Signals in the Vascular Wall: Implications for Marfan Syndrome (2007) (118)
- Functional Dissection of Reelin Signaling by Site-Directed Disruption of Disabled-1 Adaptor Binding to Apolipoprotein E Receptor 2: Distinct Roles in Development and Synaptic Plasticity (2006) (116)
- More than Cholesterol Transporters: Lipoprotein Receptors in CNS Function and Neurodegeneration (2014) (116)
- LRP1 Controls Intracellular Cholesterol Storage and Fatty Acid Synthesis through Modulation of Wnt Signaling* (2009) (115)
- The low-density-lipoprotein receptor-related protein (LRP) is processed by furin in vivo and in vitro. (1996) (115)
- Reelin Mobilizes a VAMP7-Dependent Synaptic Vesicle Pool and Selectively Augments Spontaneous Neurotransmission (2013) (110)
- Lipoprotein receptors – an evolutionarily ancient multifunctional receptor family (2010) (106)
- Essential Role of the Apolipoprotein E Receptor-2 in Sperm Development* (2003) (106)
- Asialoglycoprotein receptor deficiency in mice lacking the minor receptor subunit. (1994) (105)
- Suberoylanilide Hydroxamic Acid (Vorinostat) Up-regulates Progranulin Transcription (2011) (104)
- Activity-dependent FUS dysregulation disrupts synaptic homeostasis (2014) (104)
- Insulin-secreting beta-cell dysfunction induced by human lipoproteins. (2003) (103)
- Low density lipoprotein receptor-related protein mediates endocytosis of monoclonal antibodies in cultured cells and rabbit liver. (1990) (103)
- Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells (2016) (103)
- Apolipoprotein E Receptors Are Required for Reelin-induced Proteasomal Degradation of the Neuronal Adaptor Protein Disabled-1* (2004) (102)
- Signaling through LRP1: Protection from atherosclerosis and beyond. (2011) (101)
- Insulin stimulates receptor-mediated uptake of apoE-enriched lipoproteins and activated alpha 2-macroglobulin in adipocytes. (1993) (99)
- ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease (2017) (98)
- Normal Sorting but Defective Endocytosis of the Low Density Lipoprotein Receptor in Mice with Autosomal Recessive Hypercholesterolemia* (2003) (97)
- Malformation of the radial glial scaffold in the dentate gyrus of reeler mice, scrambler mice, and ApoER2/VLDLR‐deficient mice (2003) (96)
- Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Controls Endocytosis and c-CBL-mediated Ubiquitination of the Platelet-derived Growth Factor Receptor β (PDGFRβ)* (2005) (93)
- Initial hepatic removal of chylomicron remnants is unaffected but endocytosis is delayed in mice lacking the low density lipoprotein receptor. (1995) (92)
- Lipoprotein and receptor interactions in vivo (1995) (92)
- Cellular uptake of saposin (SAP) precursor and lysosomal delivery by the low density lipoprotein receptor‐related protein (LRP) (1998) (92)
- Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD (2014) (91)
- Remnant lipoproteins inhibit malaria sporozoite invasion of hepatocytes (1996) (89)
- Dentate Granule Cells in Reeler Mutants and VLDLR and ApoER2 Knockout Mice (2002) (88)
- Topological mapping of complement component C9 by recombinant DNA techniques suggests a novel mechanism for its insertion into target membranes. (1987) (88)
- The signal sequence receptor has a second subunit and is part of a translocation complex in the endoplasmic reticulum as probed by bifunctional reagents (1990) (88)
- Two receptor systems are involved in the plasma clearance of tissue-type plasminogen activator (t-PA) in vivo. (1995) (88)
- The Pro-Neurotrophin Receptor Sortilin Is a Major Neuronal Apolipoprotein E Receptor for Catabolism of Amyloid-β Peptide in the Brain (2013) (87)
- The Modular Adaptor Protein Autosomal Recessive Hypercholesterolemia (ARH) Promotes Low Density Lipoprotein Receptor Clustering into Clathrin-coated Pits* (2005) (85)
- Apolipoprotein E receptors in the nervous system (2009) (84)
- Apaf-1 deficiency and neural tube closure defects are found in fog mice (2001) (83)
- Origin, maturation, and astroglial transformation of secondary radial glial cells in the developing dentate gyrus (2010) (82)
- Genetic Modulation of Tau Phosphorylation in the Mouse (2003) (82)
- The LDL receptor gene family: signaling functions during development (2001) (81)
- Progranulin Does Not Bind Tumor Necrosis Factor (TNF) Receptors and Is Not a Direct Regulator of TNF-Dependent Signaling or Bioactivity in Immune or Neuronal Cells (2013) (81)
- Efficient construction of cDNA libraries in plasmid expression vectors using an adaptor strategy. (1986) (81)
- Cellular signalling by lipoprotein receptors (2000) (80)
- Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency (2017) (80)
- An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo. (2014) (80)
- Trypanosoma cruzi Utilizes the Host Low Density Lipoprotein Receptor in Invasion (2011) (79)
- Two Receptor Systems Are Involved in the Plasma Clearance of Tissue Factor Pathway Inhibitor in Vivo(*) (1995) (79)
- Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase. (1996) (78)
- A Bull's Eye for Targeted Lung Cancer Therapy (2004) (77)
- The LDL-receptor-related protein ??? portrait of a multifunctional receptor (1993) (76)
- Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase. (2003) (75)
- Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System (2011) (75)
- ApoE Receptor 2 Controls Neuronal Survival in the Adult Brain (2006) (74)
- LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins (2014) (74)
- The nuclear hormone receptor PPARγ counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells (2012) (74)
- Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice (2016) (72)
- Coaxing the LDL Receptor Family into the Fold (2003) (72)
- Normal Development and Fertility of Knockout Mice Lacking the Tumor Suppressor Gene LRP1b Suggest Functional Compensation by LRP1 (2004) (72)
- Lymphoangiocrine signals promote cardiac growth and repair (2020) (72)
- Reelin protects against amyloid β toxicity in vivo (2015) (72)
- Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses* (2016) (71)
- LRP1 Regulates Architecture of the Vascular Wall by Controlling PDGFRβ-Dependent Phosphatidylinositol 3-Kinase Activation (2009) (71)
- Reelin Signals through Apolipoprotein E Receptor 2 and Cdc42 to Increase Growth Cone Motility and Filopodia Formation (2010) (70)
- Effect of the 39-kDa receptor-associated protein on the hepatic uptake and endocytosis of chylomicron remnants and low density lipoproteins in the rat. (1994) (70)
- The Pafah1b Complex Interacts with the Reelin Receptor VLDLR (2007) (69)
- Constitutive and ligand-induced EGFR signaling triggers distinct and mutually exclusive downstream signaling networks (2014) (68)
- Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Modulates N-Methyl-d-aspartate (NMDA) Receptor-dependent Intracellular Signaling and NMDA-induced Regulation of Postsynaptic Protein Complexes* (2013) (67)
- Macrophage Low-Density Lipoprotein Receptor-Related Protein Deficiency Enhances Atherosclerosis in ApoE/LDLR Double Knockout Mice (2006) (67)
- TDP-43 in central nervous system development and function: clues to TDP-43-associated neurodegeneration (2012) (66)
- LDL Receptor‐Related Proteins in Neurodevelopment (2003) (66)
- The Major Subunit of the Asialoglycoprotein Receptor Is Expressed on the Hepatocellular Surface in Mice Lacking the Minor Receptor Subunit* (1996) (65)
- Reelin induces EphB activation (2013) (64)
- LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis (2017) (64)
- Structure and biosynthesis of the signal-sequence receptor. (1990) (62)
- Disruption of LDL but not VLDL clearance in autosomal recessive hypercholesterolemia. (2007) (62)
- News on the molecular regulation and function of hepatic low-density lipoprotein receptor and LDLR-related protein 1 (2017) (61)
- Prosaposin is a regulator of progranulin levels and oligomerization (2016) (61)
- Mutations in VLDLR as a Cause for Autosomal Recessive Cerebellar Ataxia With Mental Retardation (Dysequilibrium Syndrome) (2009) (60)
- LRP: a bright beacon at the blood-brain barrier. (2003) (59)
- APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice (2013) (58)
- Correction: LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation (1993) (57)
- Defective splicing of Megf7/Lrp4, a regulator of distal limb development, in autosomal recessive mulefoot disease. (2006) (55)
- Differential Recognition of α1-Antitrypsin-Elastase and α1-Antichymotrypsin-Cathepsin G Complexes by the Low Density Lipoprotein Receptor-related Protein (*) (1995) (54)
- Low density lipoprotein receptor-related protein is necessary for the internalization of both tissue-type plasminogen activator-inhibitor complexes and free tissue-type plasminogen activator. (1994) (53)
- ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice (2016) (53)
- Avian and murine LR8B and human apolipoprotein E receptor 2: differentially spliced products from corresponding genes. (1997) (52)
- The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease (2017) (52)
- cDNA cloning of granzyme C, a granule-associated serine protease of cytolytic T lymphocytes. (1988) (52)
- Apolipoprotein E competitively inhibits receptor-dependent low density lipoprotein uptake by the liver but has no effect on cholesterol absorption or synthesis in the mouse. (1995) (51)
- Lrp4 Regulates Initiation of Ureteric Budding and Is Crucial for Kidney Formation – A Mouse Model for Cenani-Lenz Syndrome (2010) (51)
- Low density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-CBL-mediated ubiquitination of the platelet-derived growth factor receptor beta (PDGFR beta). (2005) (50)
- Integration of Endocytosis and Signal Transduction by Lipoprotein Receptors (2003) (50)
- Functional Roles of the Interaction of APP and Lipoprotein Receptors (2017) (49)
- The Low Density Lipoprotein Receptor-related Protein Can Function Independently from Heparan Sulfate Proteoglycans in Tissue Factor Pathway Inhibitor Endocytosis* (1996) (48)
- Structure of the low-density lipoprotein receptor-related protein (LRP) promoter. (1989) (46)
- Low-Density Lipoprotein Receptor-Related Protein-1 Protects Against Hepatic Insulin Resistance and Hepatic Steatosis (2016) (46)
- Genetic variants of ApoE and ApoER2 differentially modulate endothelial function (2014) (46)
- The Reelin Receptors Apoer2 and Vldlr Coordinate the Patterning of Purkinje Cell Topography in the Developing Mouse Cerebellum (2008) (46)
- An Extrahepatic Receptor-associated Protein-sensitive Mechanism Is Involved in the Metabolism of Triglyceride-rich Lipoproteins* (1999) (46)
- Regulation of cyclic GMP formation by soluble guanylate cyclase: stimulation by NO-containing compounds. (1984) (45)
- LRP1 Controls cPLA2 Phosphorylation, ABCA1 Expression and Cellular Cholesterol Export (2009) (44)
- A role for suppressed incisor cuspal morphogenesis in the evolution of mammalian heterodont dentition (2009) (43)
- Phosphoinositide Binding by the Disabled-1 PTB Domain Is Necessary for Membrane Localization and Reelin Signal Transduction* (2005) (43)
- Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease (2018) (43)
- Expanding functions of lipoprotein receptors We acknowledge support from the National Institutes of Health, the Alexander-von-Humboldt Foundation, the American Heart Association, and the University of Texas Southwestern Medical Center. Published, JLR Papers in Press, November 17, 2008. (2009) (42)
- Ectodomains of the LDL Receptor-Related Proteins LRP1b and LRP4 Have Anchorage Independent Functions In Vivo (2010) (42)
- Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo (2015) (42)
- C1 Inhibitor-C1s Complexes Are Internalized and Degraded by the Low Density Lipoprotein Receptor-related Protein* (1997) (42)
- Loss of Reelin protects against atherosclerosis by reducing leukocyte–endothelial cell adhesion and lesion macrophage accumulation (2016) (41)
- Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol. (2004) (41)
- Smooth Muscle LDL Receptor–Related Protein-1 Inactivation Reduces Vascular Reactivity and Promotes Injury-Induced Neointima Formation (2009) (41)
- Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium. (2018) (40)
- Cancer. A bull's eye for targeted lung cancer therapy. (2004) (39)
- Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A (2021) (39)
- The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development (2014) (38)
- Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning (2014) (37)
- Role of Smooth Muscle cGMP/cGKI Signaling in Murine Vascular Restenosis (2008) (36)
- LRP1 Deficiency in Vascular SMC Leads to Pulmonary Arterial Hypertension That Is Reversed by PPARγ Activation. (2019) (35)
- Homologous recombination for gene replacement in mouse cell lines. (1994) (34)
- LRP1b shows restricted expression in human tissues and binds to several extracellular ligands, including fibrinogen and apoE – carrying lipoproteins (2011) (33)
- Characterization and distribution of Reelin-positive interneuron subtypes in the rat barrel cortex. (2014) (33)
- Functions of the LDL Receptor Gene Family (1994) (33)
- Erratum: Reelin signaling directly affects radial glia morphology and biochemical maturation (Development vol. 130 (4597-4609)) (2003) (32)
- Imaging Subcellular Dynamics with Fast and Light-Efficient Volumetrically Parallelized Microscopy. (2017) (32)
- Differential Signaling by Adaptor Molecules LRP1 and ShcA Regulates Adipogenesis by the Insulin-like Growth Factor-1 Receptor* (2011) (32)
- Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling (2018) (32)
- Cholesterol, hedgehog and embryogenesis (1997) (31)
- Lipoprotein receptors in the vascular wall (2004) (31)
- Intracellular lipid metabolism impairs &bgr; cell compensation during diet-induced obesity (2018) (30)
- Lrp4: A novel modulator of extracellular signaling in craniofacial organogenesis (2010) (30)
- Abnormal positioning of granule cells alters afferent fiber distribution in the mouse fascia dentata: Morphologic evidence from reeler, apolipoprotein E receptor 2‐, and very low density lipoprotein receptor knockout mice (2002) (30)
- Macrophage VLDL Receptor Promotes PAFAH Secretion in Mother’s Milk and Suppresses Systemic Inflammation in Nursing Neonates (2012) (29)
- Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by reelin signaling mutant mice (2013) (29)
- Convergent Signaling Pathways Controlled by LRP1 (Receptor-related Protein 1) Cytoplasmic and Extracellular Domains Limit Cellular Cholesterol Accumulation* (2016) (29)
- The gene for the human putative apoE receptor is on chromosome 12 in the segment q13-14. (1989) (28)
- Expression of a recombinant full-length LRP1B receptor in human non-small cell lung cancer cells confirms the postulated growth-suppressing function of this large LDL receptor family member (2016) (28)
- Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia. (2017) (28)
- Activation of ERK signaling upon alternative protease nexin‐1 internalization mediated by syndecan‐1 (2006) (27)
- Secreted Progranulin Is a Homodimer and Is Not a Component of High Density Lipoproteins (HDL)* (2013) (26)
- Involvement of the Apoer2 and Lrp1 receptors in mediating the pathological effects of ApoE4 in vivo. (2014) (26)
- Endocytosis of Hepatic Lipase and Lipoprotein Lipase into Rat Liver Hepatocytes in Vivo Is Mediated by the Low Density Lipoprotein Receptor-related Protein* (2004) (26)
- ApoER2 Function in the Establishment and Maintenance of Retinal Synaptic Connectivity (2011) (26)
- Deconstructing the LDL receptor — a rhapsody in pieces (2001) (26)
- The LDL receptor gene family, apolipoprotein B and cholesterol in embryonic development. (1999) (26)
- NGP 555, a γ-secretase modulator, lowers the amyloid biomarker, Aβ42, in cerebrospinal fluid while preventing Alzheimer's disease cognitive decline in rodents (2016) (25)
- Serum amyloid A delivers retinol to intestinal myeloid cells to promote adaptive immunity (2021) (25)
- Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1 (2001) (24)
- Differential functions of the Apoer2 intracellular domain in selenium uptake and cell signaling (2009) (24)
- The 68 kDa protein of signal recognition particle contains a glycine‐rich region also found in certain RNA‐binding proteins (1990) (23)
- Lrp4 Domains Differentially Regulate Limb/Brain Development and Synaptic Plasticity (2015) (22)
- The switch on the RAPper's necklace... (2006) (22)
- Contribution of the Reelin signaling pathways to nociceptive processing (2008) (21)
- The apoE receptor apoER2 is involved in the maintenance of efficient synaptic plasticity (2005) (21)
- Human apolipoprotein E isoforms differentially affect bone mass and turnover in vivo (2013) (21)
- Gene targets and approaches for raising HDL. (1999) (20)
- Differential recognition of alpha 1-antitrypsin-elastase and alpha 1-antichymotrypsin-cathepsin G complexes by the low density lipoprotein receptor-related protein. (1995) (18)
- Wnt signaling in the murine diastema. (2012) (18)
- Antiphospholipid Antibodies Attenuate Endothelial Repair and Promote Neointima Formation in Mice (2014) (17)
- High-Fat Diet Changes Hippocampal Apolipoprotein E (ApoE) in a Genotype- and Carbohydrate-Dependent Manner in Mice (2016) (17)
- Loss of Apaf-1 leads to partial rescue of the HAND2-null phenotype. (2005) (16)
- Correction: Lrp4 Modulates Extracellular Integration of Cell Signaling Pathways in Development (2009) (16)
- Low-density lipoprotein receptor–related protein-1 dysfunction synergizes with dietary cholesterol to accelerate steatohepatitis progression (2018) (16)
- FE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation (2016) (16)
- “Devolution” of bipedality (2008) (16)
- Lipoprotein receptors: beacons to neurons? (2001) (15)
- 39-kDa receptor-associated protein (RAP) facilitates secretion and ligand binding of extracellular region of very-low-density-lipoprotein receptor: implications for a distinct pathway from low-density-lipoprotein receptor. (1999) (15)
- Extracting β-amyloid from Alzheimer's disease (2012) (14)
- Identification of alternatively spliced Dab1 and Fyn isoforms in pig (2011) (14)
- How We Can Rebuild Trust in Science-And Why We Must. (2018) (13)
- PI3-Kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination (2003) (13)
- Selective Inactivation of Reelin in Inhibitory Interneurons Leads to Subtle Changes in the Dentate Gyrus But Leaves Cortical Layering and Behavior Unaffected (2019) (13)
- Heparan sulfate-dependent and low density lipoprotein receptor-related protein-dependent catabolic pathways for lipoprotein lipase in mouse embryonic fibroblasts. (1996) (12)
- Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation (2018) (12)
- Ephrin Bs and canonical Reelin signalling (2016) (11)
- Lrp4/Wise regulates palatal rugae development through Turing-type reaction-diffusion mechanisms (2018) (11)
- Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin (2018) (10)
- Generation and Characterization of an Nse-CreERT2 Transgenic Line Suitable for Inducible Gene Manipulation in Cerebellar Granule Cells (2014) (10)
- Disruption of Cholesterol 7α-Hydroxylase Gene in Mice (1996) (9)
- A key requirement for synaptic Reelin signaling in ketamine-mediated behavioral and synaptic action (2021) (9)
- Plasmodium sporozoites invade cells with targeted deletions in the LDL receptor related protein. (2000) (9)
- TDP-43 is a developmentally regulated protein essential for early embryonic development. (2010) (8)
- Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression. (2019) (8)
- Reelin depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes (2020) (8)
- Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmonary Hypertension (2022) (8)
- Is apolipoprotein e required for cognitive function in humans?: implications for Alzheimer drug development. (2014) (7)
- CD11c+CD88+CD317+ myeloid cells are critical mediators of persistent CNS autoimmunity (2020) (7)
- Overview: The Long and Winding Road to Understanding Alzheimer's Disease (2007) (7)
- Mouse models as tools for dissecting disorders of lipoprotein metabolism. (2003) (7)
- FE65 and FE65L1 amyloid precursor protein‐binding protein compound null mice display adult‐onset cataract and muscle weakness (2015) (7)
- The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development (2014) (7)
- Reelin signaling modulates GABAB receptor function in the neocortex (2020) (7)
- Sodium-hydrogen exchanger 6 (NHE6) deficiency leads to hearing loss, via reduced endosomal signalling through the BDNF/Trk pathway (2020) (6)
- Reelin Depletion Protects Against Atherosclerosis by Decreasing Vascular Adhesion of Leukocytes (2021) (6)
- Conditional animal models for the study of lipid metabolism and lipid disorders. (2007) (6)
- Physiologic Reelin does not play a strong role in protection against acute stroke (2016) (6)
- Animal models for disorders of hepatic lipoprotein metabolism (1995) (5)
- Splicing therapeutics for Alzheimer's disease (2016) (5)
- Building a better blood-brain barrier (2017) (4)
- Putative apolipoprotein receptor gene (LRP, A2MR) is not rearranged in either myxoid liposarcoma or lipomas with translocations in 12q13-14. (1992) (4)
- Reelin changes hippocampal learning in aging and Alzheimer’s disease (2021) (4)
- Apolipoprotein E receptor 2 deficiency decreases endothelial adhesion of monocytes and protects against autoimmune encephalomyelitis (2021) (4)
- Reelin restricts dendritic growth of interneurons in the neocortex. (2021) (3)
- News on the molecular regulation and function of hepatic LDLR and LRP1 (2019) (3)
- Protein Phosphatase 2A Activation Via ApoER2 in Trophoblasts Drives Preeclampsia in a Mouse Model of the Antiphospholipid Syndrome (2021) (3)
- Apolipoprotein e receptor 2 and very-low-density lipoprotein receptor: An overview (2008) (3)
- Wnt5a Promotes Lysosomal Cholesterol Egress and Protects Against Atherosclerosis (2021) (3)
- NGP 555, a γ-secretase modulator, shows a beneficial shift in the ratio of amyloid biomarkers in human cerebrospinal fluid at safe doses (2019) (3)
- Constructing expression cDNA libraries using unphosphorylated adaptors. (1988) (3)
- Reelin Regulates Neuronal Excitability through Striatal-Enriched Protein Tyrosine Phosphatase (STEP61) and Calcium Permeable AMPARs in an NMDAR-Dependent Manner (2021) (3)
- C1 inhibitor-C1s complexes are internalized and degraded by the low density lipoprotein receptor-related protein. (1998) (3)
- Role of smooth muscle cGMP/cGKI signaling in a mouse model of restenosis (2006) (2)
- Harald Signaling Receptor Clustering Is Involved in Reelin (2004) (2)
- NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load (2021) (2)
- Sodium Phenylbutyrate-Taurursodiol for ALS. (2020) (2)
- NHE6-Depletion Corrects ApoE4-Mediated Synaptic Impairments and Reduces Amyloid Plaque Load (2021) (2)
- Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins ( fl-very low density lipoproteins / chylomicrons / familial hypercholesterolemia / cell-surface receptors / lysosomal hydrolysis ) (2)
- Correction: Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System (2019) (2)
- Author response: APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice (2013) (1)
- We-W43:6 Macrophage low-density lipoprotein receptor-related protein deficiency enhances atherosclerosis (2006) (1)
- Title : The nuclear hormone receptor PPARγ counteracts vascular calcification by inhibiting Wnt 5 a signalling in vascular smooth muscle cells (1)
- Workshop abstractMechanisms of hepatic uptake and endocytosis of chylomicron remnants (1994) (1)
- Author response: LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis (2017) (1)
- Dissection of the chylomicron remnant clearance pathway (1994) (1)
- Author Correction: Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation (2018) (1)
- Short communication Plasmodium sporozoites invade cells with targeted deletions in the LDL receptor related protein (2000) (1)
- High precision spatial and temporal control of neural circuitry using a semi-automated multi-wavelength nanopatterning system (2009) (1)
- Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation (2018) (1)
- Function of smooth muscle cGMP-dependent protein kinase type I in a mouse model of restenosis (2005) (1)
- Gene transfer and disruption strategies to elucidate hepatic lipoprotein receptor functions. (1995) (1)
- Crystal Structure of the Disabled-1 (Dab1) PTB domain-ApoER2 peptide complex (2003) (0)
- Complex genetic functions of the LDL receptor gene family (2000) (0)
- Wnt5a Belongs to the Lysosomal Cholesterol-Sensing Machinery that Controls mTORC1 (2019) (0)
- Science Signaling Podcast: 25 November 2014 (2014) (0)
- Potential roles of the LDL receptor gene family in Alzheimer disease (2000) (0)
- Efficient construction ofcDNAlibraries inplasmid expression vectors using anadaptor strategy (1986) (0)
- related protein deficiency - receptor Elevated plasma factor VIII in a mouse model of low-density lipoprotein (2013) (0)
- Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism (2018) (0)
- Review Molecular mechanisms of lipoprotein receptor signalling (2005) (0)
- The “6B” Strategy: Build Back a Better Blood–Brain Barrier (2022) (0)
- FunctionalDissectionofReelinSignalingbySite-Directed DisruptionofDisabled-1AdaptorBindingtoApolipoprotein EReceptor2:DistinctRolesinDevelopmentand SynapticPlasticity (2006) (0)
- Table of Contents (1996) (0)
- The cytoplasmic and extracellular domains of LRP1 promote a convergent mechanism for feedback control of cholesterol synthesis and export, and protect against intracellular cholesterol accumulation (2015) (0)
- ECM protein fibulin_5 and development of atherosclerosis (2006) (0)
- A TGFβLRP1/Wnt5a pathway protects against intracellular cholesterol accumulation through inhibition of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity, and increased cholesterol efflux (2014) (0)
- Science Signaling Podcast: 7 July 2015 (2015) (0)
- Cellular uptake of lipoproteins through LRP is apo e dependent (1990) (0)
- Vascular remodelling in the absence and presence of cGKI (2007) (0)
- Abstract 15676: Chronic Activation of Platelet-derived Growth Factor {beta}Receptor Signaling in Vascular Smooth Muscle Cells Increases Apoptosis in Atherosclerotic Plaques via Downregulation of Bcl-2 (2011) (0)
- MechanismsSynaptic Potentiation Mediated by Postsynaptic Attenuation of Paired-Pulse Facilitation Associated (2015) (0)
- Cpla2 and Lrp1 Deficiency Promote Severe Atherosclerosis Driven by LXRa/ABCA1 Dysfunction in Smooth Muscle Cells (2021) (0)
- Absence of Cpla2 in Lrp1 Smooth Muscle Cell-Deficient Mice Promotes Severe Aortic Atherosclerotic Disease (2020) (0)
- Author Correction: Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation (2018) (0)
- The ldl receptor supergene family (1992) (0)
- Author response: NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load (2021) (0)
- ID: 328 Control of Vascular Wall Integrity by LRP1 (2006) (0)
- Normal brain development in Lrp4 ECD/ECD and Lrp4 -/- mice. (2015) (0)
- W13.317 Characterization of LRP1b, a large member of the LDL receptor family and putative tumor suppressor, in the mouse (2004) (0)
- S3-02-05 TBD (2006) (0)
- Convergent signaling pathways controlled by LRP1 cytoplasmic and extracellular domains limit cellular cholesterol accumulation (2016) (0)
- Erythropoietin mimetic peptides and the future (2000) (0)
- Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism (2022) (0)
- Biolistic transfection and expression analysis of acute cortical slices (2020) (0)
- The LDL-receptor family—mediators of signal transduction (2009) (0)
- ApoE Receptors in the Brain: Novel Signaling Pathways with Potential Relevance for Alzheimer’s Disease (2001) (0)
- Correcting the Aberrant Progranulin-Deficient Lysosomal Proteome via HDAC Inhibition (2022) (0)
- The Role of ApoER2 Exon19 Splicing in Retinal Degeneration (2008) (0)
- The role of ApoE and ApoE receptors for synaptic dysfunction in Alzheimer's disease (2009) (0)
- The LDL gene receptor family (1999) (0)
- Apoer2-ICD-Dependent Regulation of the Hippocampal Translatome (2022) (0)
- Genetic Manipulation of Lipoprotein Receptors: Implications for Lipid Metabolism and Atherosclerosis (1995) (0)
- Crystal structure of the murine Disabled-1 (Dab1) PTB domain-ApoER2 peptide-PI-4,5P2 ternary complex (2003) (0)
- Low density lipoprotein receptor knockout mouse (1994) (0)
- Sodium-hydrogen exchanger 6 (NHE6) deficiency leads to hearing loss, via reduced endosomal signalling through the BDNF/Trk pathway (2020) (0)
- Genetic analysis of LDL receptor-related genes (1997) (0)
- Macrophage low-density lipoprotein receptor-related protein deficiency enhances atherosclerosis in mice (2006) (0)
- Analysis of lipoprotein removal pathways in transgenic and knockout mice (1999) (0)
- This information is current as Health and Disease Scavenger Receptors and Their Roles in A Consensus Definitive Classification of (2017) (0)
- Lymphoangiocrine signals promote cardiac growth and repair (2020) (0)
- THERAPIES THAT ENHANCE PROGRANULIN EXPRESSION (2014) (0)
- Author response: Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease (2018) (0)
- Analysis of ligand binding to the LDL receptor-related protein (LRP) (1994) (0)
- ApoE Lipid Homeostasis Disease The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease (2010) (0)
- Lipoprotein uptake in mouse fibroblasts lacking the LDL receptor, the LRP or both (1995) (0)
- Is the α2M/LRP-1 axis integral to the allergenicity of proteases? (P6220) (2013) (0)
- P2-414 FE65/FE65L1 compound null mice have neuroanatomical defects (2004) (0)
- The role of LRP in mediating the synergistic pathological effects of apoE4 and amyloid-β in vivo (2010) (0)
- Mice Increases Atherosclerosis Independent of Plasma Cholesterol Hepatic Low-Density Lipoprotein Receptor-Related Protein Deficiency in (2010) (0)
- O4-05-07 FE65 amyloid precursor-protein binding proteins are essential for brain development (2006) (0)
- Antiphospholipid Antibodies Promote Leukocyte-Endothelial Cell Adhesion by Antagonizing Endothelial NO Synthase Via b2GPI and ApoER2. (2009) (0)
- receptor-related protein deficiency Elevated plasma factor VIII in a mouse model of low-density lipoprotein (2010) (0)
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What Schools Are Affiliated With Joachim Herz?
Joachim Herz is affiliated with the following schools:
