Joachim Lingner
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Swiss molecular biologist
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Joachim Lingnerbiology Degrees
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Molecular Biology
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Biology
Joachim Lingner's Degrees
- PhD Molecular Biology University of Zurich
- Bachelors Biology University of Zurich
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(Suggest an Edit or Addition)According to Wikipedia, Joachim Lingner is a Swiss molecular biologist. He holds the professorship for life sciences and leads the Lingner Lab at the École Polytechnique Fédérale de Lausanne . Career Lingner obtained his PhD from the Biozentrum of the University of Basel in 1992. In 1993 he joined the Howard Hughes Medical Institute at University of Colorado at Boulder for postdoctoral studies under the supervision of Thomas Cech. He then joined Swiss Institute for Experimental Cancer Research in Lausanne, Switzerland, first as a junior group leader in 1997 and became senior group leader in 2002. In 2005 he was appointed as associate professor at EPF Lausanne. Since 2009, Lingner is a full professor at EPF Lausanne.
Joachim Lingner's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Reverse transcriptase motifs in the catalytic subunit of telomerase. (1997) (1274)
- Telomeric Repeat–Containing RNA and RNA Surveillance Factors at Mammalian Chromosome Ends (2007) (1176)
- Telomerase catalytic subunit homologs from fission yeast and human. (1997) (1171)
- Direct activation of TERT transcription by c-MYC (1999) (897)
- Telomere Length Homeostasis Is Achieved via a Switch between Telomerase- Extendible and -Nonextendible States (2004) (531)
- A highly selective telomerase inhibitor limiting human cancer cell proliferation (2001) (409)
- Telomerase and DNA end replication: no longer a lagging strand problem? (1995) (378)
- The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase (2010) (337)
- The Rat1p 5' to 3' exonuclease degrades telomeric repeat-containing RNA and promotes telomere elongation in Saccharomyces cerevisiae. (2008) (302)
- Telomere length homeostasis requires that telomerase levels are limiting (2006) (297)
- Telomere length homeostasis (2006) (292)
- The human CST complex is a terminator of telomerase activity (2012) (291)
- Purification of telomerase from Euplotes aediculatus: requirement of a primer 3' overhang. (1996) (274)
- Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity. (1997) (261)
- Mechanism of Human Telomerase Inhibition by BIBR1532, a Synthetic, Non-nucleosidic Drug Candidate* (2002) (256)
- TERRA: telomeric repeat-containing RNA (2009) (254)
- TIN2-Tethered TPP1 Recruits Human Telomerase to Telomeres In Vivo (2010) (251)
- Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action (2007) (248)
- Human Protection of Telomeres 1 (POT1) Is a Negative Regulator of Telomerase Activity In Vitro (2005) (227)
- The Human RNA Surveillance Factor UPF1 Is Required for S Phase Progression and Genome Stability (2006) (217)
- A Human Homolog of Yeast Est1 Associates with Telomerase and Uncaps Chromosome Ends When Overexpressed (2003) (208)
- Molecular Dissection of Telomeric Repeat-Containing RNA Biogenesis Unveils the Presence of Distinct and Multiple Regulatory Pathways (2010) (207)
- Functional characterization of the TERRA transcriptome at damaged telomeres (2014) (198)
- Telomerase RNAs of different ciliates have a common secondary structure and a permuted template. (1994) (194)
- Regulation of the human telomerase reverse transcriptase gene (2002) (192)
- Human telomerase RNA accumulation in Cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation. (2007) (187)
- Telomere functions grounding on TERRA firma. (2015) (177)
- Human telomerase contains two cooperating telomerase RNA molecules (2001) (167)
- Telomerase repeat addition processivity is increased at critically short telomeres in a Tel1-dependent manner in Saccharomyces cerevisiae. (2007) (158)
- Telomerase: biochemical considerations for enzyme and substrate. (2002) (152)
- TERRA biogenesis, turnover and implications for function (2010) (143)
- The FIP1 gene encodes a component of a yeast pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase (1995) (138)
- TERRA Promotes Telomere Shortening through Exonuclease 1–Mediated Resection of Chromosome Ends (2012) (136)
- Telomerase-dependent repeat divergence at the 3' ends of yeast telomeres. (2000) (126)
- Structure of Active, Dimeric Human Telomerase (2013) (123)
- Telomerase and chromosome end maintenance. (1998) (121)
- The THO complex component Thp2 counteracts telomeric R‐loops and telomere shortening (2013) (117)
- Cloning and expression of the essential gene for poly(A) polymerase from S. cerevisiae (1991) (117)
- TERRA-reinforced association of LSD1 with MRE11 promotes processing of uncapped telomeres. (2014) (112)
- Replication of telomeres and the regulation of telomerase. (2013) (106)
- Telomeres: The silence is broken (2008) (105)
- Molecular basis of telomere syndrome caused by CTC1 mutations (2013) (102)
- Tel1 kinase and subtelomere‐bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast (2007) (101)
- The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast (2011) (97)
- A quantitative telomeric chromatin isolation protocol identifies different telomeric states (2013) (95)
- Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast (2011) (95)
- Basis for changes in DNA recognition by the EcoR124 and EcoR124/3 type I DNA restriction and modification enzymes. (1989) (94)
- Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting (2000) (90)
- RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops (2020) (88)
- Regulation of human telomerase activity: repression by normal chromosome 3 abolishes nuclear telomerase reverse transcriptase transcripts but does not affect c-Myc activity. (2001) (87)
- Intracellular trafficking of yeast telomerase components (2002) (82)
- A three-state model for the regulation of telomerase by TERRA and hnRNPA1 (2013) (81)
- Impact of oxidative stress on telomere biology. (2018) (79)
- Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase. (2016) (78)
- Molecular Basis for Telomere Repeat Divergence in Budding Yeast (2001) (77)
- Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay (2007) (77)
- Purification and characterization of poly(A) polymerase from Saccharomyces cerevisiae. (1991) (75)
- Telomerase limits the extent of base pairing between template RNA and telomeric DNA (2005) (68)
- 3'-end labeling of RNA with recombinant yeast poly(A) polymerase. (1993) (64)
- The Double Life of UPF1 in RNA and DNA Stability Pathways (2006) (63)
- Telomeres and telomerase. (1999) (61)
- Protein–RNA and protein–protein interactions mediate association of human EST1A/SMG6 with telomerase (2007) (61)
- A practical qPCR approach to detect TERRA, the elusive telomeric repeat-containing RNA. (2017) (56)
- CST for the grand finale of telomere replication (2013) (55)
- The telomeric DNA damage response occurs in the absence of chromatin decompaction (2017) (52)
- Telomere Length Homeostasis Responds to Changes in Intracellular dNTP Pools (2013) (48)
- The finger subdomain of yeast telomerase cooperates with Pif1p to limit telomere elongation (2006) (47)
- Detection of promoter activity by flow cytometric analysis of GFP reporter expression. (2002) (45)
- PRDX1 and MTH1 cooperate to prevent ROS-mediated inhibition of telomerase (2018) (45)
- Telomerase is a true reverse transcriptase. A review. (1997) (39)
- Expression and differential regulation of human TERRA at several chromosome ends (2019) (38)
- Low- to high-throughput analysis of telomerase modulators with Telospot (2007) (36)
- Telomerase Is Essential to Alleviate Pif1-Induced Replication Stress at Telomeres (2009) (30)
- AUF1/HnRNP D RNA binding protein functions in telomere maintenance. (2012) (26)
- Telomerase and the chromosome end replication problem. (1997) (24)
- The Shelterin Component TPP1 Is a Binding Partner and Substrate for the Deubiquitinating Enzyme USP7* (2014) (24)
- Yeast telomerase is specialized for C/A-rich RNA templates. (2003) (24)
- A chromosome 3-encoded repressor of the human telomerase reverse transcriptase (hTERT) gene controls the state of hTERT chromatin. (2003) (20)
- Human shelterin protein POT1 prevents severe telomere instability induced by homology‐directed DNA repair (2020) (20)
- Specific binding of telomeric G-quadruplexes by hydrosoluble perylene derivatives inhibits repeat addition processivity of human telomerase. (2012) (17)
- Rearrangements of minisatellites in the human telomerase reverse transcriptase gene are not correlated with its expression in colon carcinomas (2001) (17)
- Telomerase unplugged. (2007) (15)
- The makings of TERRA R-loops at chromosome ends (2021) (15)
- Roles of telomeres and telomerase in cancer (2011) (14)
- Telomerase inhibitors from cyanobacteria: isolation and synthesis of sulfoquinovosyl diacylglycerols from Microcystis aeruguinosa PCC 7806. (2013) (13)
- SMCHD1 Promotes ATM-dependent DNA Damage Signaling and Repair of Uncapped Telomeres (2019) (13)
- 2 The Telomerase Ribonucleoprotein Particle (2006) (13)
- Transformation-induced stress at telomeres is counteracted through changes in the telomeric proteome including SAMHD1 (2018) (12)
- PRDX1 Counteracts Catastrophic Telomeric Cleavage Events That Are Triggered by DNA Repair Activities Post Oxidative Damage. (2020) (10)
- Molecular biology: Damage control (2007) (10)
- Tel2 Finally Tells One Story (2008) (10)
- Telomere Wedding Ends in Divorce (2004) (10)
- The human telomeric proteome during telomere replication (2020) (10)
- Pharmacological Inhibition of Human Telomerase by BIBR 1532-1-MECHANISM OF HUMAN TELOMERASE INHIBITION BY BIBR 1532 , A SYNTHETIC , NON-NUCLEOSIDIC DRUG CANDIDATE (2002) (9)
- CSL controls telomere maintenance and genome stability in human dermal fibroblasts (2019) (9)
- Fingering the Ends How to Make New Telomeres (2003) (8)
- Challenging endings: How telomeres prevent fragility (2021) (8)
- Quantitative telomeric chromatin isolation protocol for human cells. (2017) (8)
- An affinity oligonucleotide displacement strategy to purify ribonucleoprotein complexes applied to human telomerase. (2008) (7)
- SMCHD1 promotes ATM‐dependent DNA damage signaling and repair of uncapped telomeres (2020) (6)
- TZAP or not to zap telomeres (2017) (5)
- A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres (2021) (4)
- S. Cerevisiae Est1/H. sapiens SMG6 protein family members function in telomere metabolism (2005) (4)
- When Telomerase Causes Telomere Loss. (2018) (4)
- ALT Telomeres Get Together with Nuclear Receptors (2015) (3)
- Related mechanisms for end processing at telomeres and DNA double-strand breaks. (2009) (3)
- RADX Sustains POT1 Function at Telomeres to Counteract RAD51 Binding, which Triggers Telomere Fragility (2020) (3)
- Cell biology. Telomere wedding ends in divorce. (2004) (2)
- Human POT1 Prevents Severe Telomere Instability Induced by Homology Directed DNA Repair (2020) (1)
- Components involved in 3?processing of precursors to polyadenylated messenger RNA (1990) (1)
- RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops (2020) (1)
- Catalytic subunit of human telomerase (1997) (1)
- Interplay of DNA polymerase lambda, Protection of Telomeres (Pot) 1 and TERRA in telomere elongation (2013) (0)
- The makings of Telomerases (2002) (0)
- Faculty Opinions recommendation of Proteasome-dependent degradation of Est1p regulates the cell cycle-restricted assembly of telomerase in Saccharomyces cerevisiae. (2006) (0)
- Faculty Opinions recommendation of TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita. (2008) (0)
- Nanoscale Spatial Organization of Chromatin in its Cellular Context, from Telomeres to Hox (2016) (0)
- cerevisiae Saccharomyces short telomeres in a Tel 1-dependent manner in Telomerase repeat addition processivity is increased at critically Material Supplemental (2007) (0)
- The telomeric DNA damage response: Insights into telomere compaction and identification of novel damage signaling factors (2018) (0)
- cerevisiae Saccharomycesshort telomeres in a Tel 1-dependent manner in Telomerase repeat addition processivity is increased at critically data (2007) (0)
- Transcriptase Transcripts but Does Not Affect c-Myc Activity ReverseNormal Chromosome 3 Abolishes Nuclear Telomerase Regulation of Human Telomerase Activity : Repression by Updated Version (2001) (0)
- Telomerase Regulation and Telomere‐Length Homeostasis (2012) (0)
- The long noncoding RNA TERRA and the telomeric DNA damage response (2013) (0)
- Telomerase and telomeric repeat containing RNA at chromosome ends (2008) (0)
- Metallic human telomerase catalytic subunit (1997) (0)
- Decision letter: TINF2 is a haploinsufficient tumor suppressor that limits telomere length (2020) (0)
- Telomerase : the reverse transcriptase subunit as a key to enzymatic function and regulation during cell immortalization (1998) (0)
- Research highlights (2007) (0)
- Detection of TERRA R-Loops at Human Telomeres. (2022) (0)
- Faculty Opinions recommendation of Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. (2004) (0)
- Protein and polynucleoti nucleic acid compounds encoding catalytic subunit of human telomerase subunit, production and applications (1997) (0)
- the State of hTERT Chromatin ) Gene Controls hTERT ( Telomerase Reverse Transcriptase Human A Chromosome 3-encoded Repressor of the Updated Version (2003) (0)
- Faculty Opinions recommendation of Tel2 regulates the stability of PI3K-related protein kinases. (2008) (0)
- TFIIH moonlighting at telomeres (2022) (0)
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