Joan B. Broderick
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Professor of chemistry and biochemistry
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Chemistry Biology
Joan B. Broderick's Degrees
- PhD Chemistry University of California, Berkeley
- Masters Chemistry Stanford University
Why Is Joan B. Broderick Influential?
(Suggest an Edit or Addition)According to Wikipedia, Joan Blanchette Broderick is a professor of chemistry and biochemistry at Montana State University known for her work on bioinorganic chemistry, especially the chemistry of iron-sulfur interactions. She was elected a member of the National Academy of Sciences in 2022.
Joan B. Broderick's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Radical S-Adenosylmethionine Enzymes (2014) (520)
- [FeFe]- and [NiFe]-hydrogenase diversity, mechanism, and maturation. (2015) (335)
- Stepwise [FeFe]-hydrogenase H-cluster assembly revealed in the structure of HydAΔEFG (2010) (247)
- Insights into [FeFe]-hydrogenase structure, mechanism, and maturation. (2011) (219)
- Escherichia coli LipA is a lipoyl synthase: in vitro biosynthesis of lipoylated pyruvate dehydrogenase complex from octanoyl-acyl carrier protein. (2000) (197)
- An anchoring role for FeS clusters: chelation of the amino acid moiety of S-adenosylmethionine to the unique iron site of the [4Fe-4S] cluster of pyruvate formate-lyase activating enzyme. (2002) (163)
- Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzyme (2008) (160)
- Electron-nuclear double resonance spectroscopic evidence that S-adenosylmethionine binds in contact with the catalytically active [4Fe-4S](+) cluster of pyruvate formate-lyase activating enzyme. (2002) (159)
- [FeFe]-hydrogenase cyanide ligands derived from S-adenosylmethionine-dependent cleavage of tyrosine. (2010) (132)
- Synthesis of the 2Fe subcluster of the [FeFe]-hydrogenase H cluster on the HydF scaffold (2010) (129)
- HydF as a scaffold protein in [FeFe] hydrogenase H‐cluster biosynthesis (2008) (121)
- Adenosylmethionine-dependent iron-sulfur enzymes: versatile clusters in a radical new role (2001) (120)
- [FeFe]-hydrogenase maturation: HydG-catalyzed synthesis of carbon monoxide. (2010) (119)
- Coordination of adenosylmethionine to a unique iron site of the [4Fe-4S] of pyruvate formate-lyase activating enzyme: a Mössbauer spectroscopic study. (2002) (117)
- [FeFe]-hydrogenase oxygen inactivation is initiated at the H cluster 2Fe subcluster. (2015) (114)
- Activation of HydA(DeltaEFG) requires a preformed [4Fe-4S] cluster. (2009) (108)
- In vitro activation of [FeFe] hydrogenase: new insights into hydrogenase maturation (2007) (106)
- The antiviral protein viperin is a radical SAM enzyme (2010) (106)
- Direct H atom abstraction from spore photoproduct C-6 initiates DNA repair in the reaction catalyzed by spore photoproduct lyase: evidence for a reversibly generated adenosyl radical intermediate. (2002) (106)
- Genome sequence of Desulfitobacterium hafniense DCB-2, a Gram-positive anaerobe capable of dehalogenation and metal reduction (2012) (95)
- Spectroscopic approaches to elucidating novel iron-sulfur chemistry in the "radical-Sam" protein superfamily. (2005) (94)
- Pyruvate formate-lyase-activating enzyme: strictly anaerobic isolation yields active enzyme containing a [3Fe-4S](+) cluster. (2000) (90)
- Pyruvate Formate-Lyase Activating Enzyme Is an Iron-Sulfur Protein (1997) (88)
- Radical SAM catalysis via an organometallic intermediate with an Fe–[5′-C]-deoxyadenosyl bond (2016) (87)
- The [4Fe-4S]1+ Cluster of Pyruvate Formate-Lyase Activating Enzyme Generates the Glycyl Radical on Pyruvate Formate-Lyase: EPR-Detected Single Turnover (2000) (86)
- Overproduction, purification, and characterization of chlorocatechol dioxygenase, a non-heme iron dioxygenase with broad substrate tolerance. (1991) (84)
- Coenzymes and Cofactors (2001) (80)
- EPR and FTIR analysis of the mechanism of H2 activation by [FeFe]-hydrogenase HydA1 from Chlamydomonas reinhardtii. (2013) (79)
- Emerging paradigms for complex iron-sulfur cofactor assembly and insertion. (2012) (77)
- [FeFe]-hydrogenase maturation. (2014) (76)
- Conversion of 3Fe-4S to 4Fe-4S Clusters in Native Pyruvate Formate-Lyase Activating Enzyme: Mössbauer Characterization and Implications for Mechanism (2000) (76)
- Glycyl radical activating enzymes: structure, mechanism, and substrate interactions. (2014) (75)
- Biosynthesis of complex iron-sulfur enzymes. (2011) (69)
- Characterization of an Active Spore Photoproduct Lyase, a DNA Repair Enzyme in the Radical S-Adenosylmethionine Superfamily* (2006) (66)
- Hydrogenase cluster biosynthesis: organometallic chemistry nature's way. (2009) (64)
- Control of radical chemistry in the AdoMet radical enzymes. (2009) (63)
- Mechanism of Radical Initiation in the Radical S-Adenosyl-l-methionine Superfamily. (2018) (60)
- Catechol dioxygenases. (1999) (59)
- Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis (2018) (58)
- Spore photoproduct lyase catalyzes specific repair of the 5R but not the 5S spore photoproduct. (2009) (53)
- [FeFe]-hydrogenase maturation: insights into the role HydE plays in dithiomethylamine biosynthesis. (2015) (50)
- Why Nature Uses Radical SAM Enzymes so Widely: Electron Nuclear Double Resonance Studies of Lysine 2,3-Aminomutase Show the 5'-dAdo• "Free Radical" Is Never Free. (2015) (48)
- The iron-sulfur cluster of pyruvate formate-lyase activating enzyme in whole cells: cluster interconversion and a valence-localized [4Fe-4S]2+ state. (2009) (45)
- Emerging themes in radical SAM chemistry. (2012) (44)
- Inactivation of E. coli pyruvate formate-lyase: role of AdhE and small molecules. (2007) (44)
- S K-edge XAS and DFT calculations on SAM dependent pyruvate formate-lyase activating enzyme: nature of interaction between the Fe4S4 cluster and SAM and its role in reactivity. (2011) (43)
- Biochemical and kinetic characterization of radical S-adenosyl-L-methionine enzyme HydG. (2013) (42)
- Identification and Characterization of a Novel Member of the Radical AdoMet Enzyme Superfamily and Implications for the Biosynthesis of the Hmd Hydrogenase Active Site Cofactor (2009) (42)
- Pyruvate formate-lyase activating enzyme: elucidation of a novel mechanism for glycyl radical formation. (2005) (38)
- H-Cluster assembly during maturation of the [FeFe]-hydrogenase (2014) (35)
- The Elusive 5'-Deoxyadenosyl Radical: Captured and Characterized by EPR and ENDOR Spectroscopies. (2019) (35)
- Pyruvate Formate-lyase, Evidence for an Open Conformation Favored in the Presence of Its Activating Enzyme* (2010) (35)
- Pyruvate Formate-lyase and Its Activation by Pyruvate Formate-lyase Activating Enzyme* (2013) (32)
- Complete stereospecific repair of a synthetic dinucleotide spore photoproduct by spore photoproduct lyase (2010) (30)
- Radical SAM enzymes: surprises along the path to understanding mechanism (2019) (29)
- Evidence for retention of biological activity of a non-heme iron enzyme adsorbed on a silver colloid: a surface-enhanced resonance Raman scattering study. (1993) (28)
- Reversible H Atom Abstraction Catalyzed by the Radical S-Adenosylmethionine Enzyme HydG (2014) (28)
- Frontiers in enzymatic C-H-bond activation. (2009) (27)
- Structural studies of the interaction of S‐adenosylmethionine with the [4Fe‐4S] clusters in biotin synthase and pyruvate formate‐lyase activating enzyme (2003) (27)
- Radical AdoMet enzymes in complex metal cluster biosynthesis. (2012) (26)
- Viperin: a radical response to viral infection (2012) (24)
- Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme (2017) (22)
- Photoinduced Electron Transfer in a Radical SAM Enzyme Generates an S-Adenosylmethionine Derived Methyl Radical. (2019) (21)
- Activation of HydA Δ EFG Requires a Preformed [ 4 Fe-4 S ] Cluster † (2009) (21)
- 8.27 – Iron–Sulfur Clusters in Enzyme Catalysis (2003) (19)
- A Redox Active [2Fe-2S] Cluster on the Hydrogenase Maturase HydF. (2016) (19)
- Radical S-Adenosyl-l-methionine Chemistry in the Synthesis of Hydrogenase and Nitrogenase Metal Cofactors* (2014) (19)
- The Elusive 5′-Deoxyadenosyl Radical: Captured and Characterized by Electron Paramagnetic Resonance and Electron Nuclear Double Resonance Spectroscopies (2019) (18)
- Special issue on iron-sulfur proteins: Structure, function, biogenesis and diseases. (2015) (18)
- Cyanide and Carbon Monoxide Ligand Formation in Hydrogenase Biosynthesis (2011) (17)
- Biochemistry: A radically different enzyme (2010) (16)
- Iron–sulfur cluster coordination in the [FeFe]‐hydrogenase H cluster biosynthetic factor HydF (2012) (16)
- S -Adenosylmethionine and Iron–Sulfur Clusters in Biological Radical Reactions: The Radical SAM Superfamily (2010) (15)
- Radical SAM enzymes in methylation and methylthiolation. (2012) (14)
- Flavodoxin cofactor binding induces structural changes that are required for protein-protein interactions with NADP(+) oxidoreductase and pyruvate formate-lyase activating enzyme. (2013) (13)
- S-Adenosyl-l-ethionine is a Catalytically Competent Analog of S-Adenosyl-l-methione (SAM) in the Radical SAM Enzyme HydG. (2021) (11)
- Electron Spin Relaxation and Biochemical Characterization of the Hydrogenase Maturase HydF: Insights into [2Fe-2S] and [4Fe-4S] Cluster Communication and Hydrogenase Activation (2017) (11)
- Mechanistic Studies of Radical SAM Enzymes: Pyruvate Formate-Lyase Activating Enzyme and Lysine 2,3-Aminomutase Case Studies. (2018) (10)
- Compositional and structural insights into the nature of the H-cluster precursor on HydF. (2018) (10)
- H-cluster assembly intermediates built on HydF by the radical SAM enzymes HydE and HydG (2019) (10)
- Chemoselective Deprotection of Triethylsilyl Ethers (2009) (9)
- Radical S-adenosylmethionine maquette chemistry: Cx3Cx2C peptide coordinated redox active [4Fe–4S] clusters (2019) (9)
- Active-Site Controlled, Jahn-Teller Enabled Regioselectivity in Reductive S-C Bond Cleavage of S-Adenosylmethionine in Radical SAM Enzymes. (2020) (9)
- Combined Mössbauer spectroscopic, multi-edge X-ray absorption spectroscopic, and density functional theoretical study of the radical SAM enzyme spore photoproduct lyase (2014) (9)
- Assembling iron-sulfur clusters in the cytosol. (2007) (7)
- An Efficient Deprotection of N-Trimethylsilylethoxymethyl (SEM) Groups From Dinucleosides and Dinucleotides (2010) (7)
- Secondary structure analysis of peptides with relevance to iron–sulfur cluster nesting (2018) (6)
- The Radical SAM enzyme Spore Photoproduct Lyase: Properties of the Ω Organometallic Intermediate and Identification of Stable Protein Radicals Formed During Substrate-Free Turnover. (2020) (6)
- Examining Pathways of Iron and Sulfur Acquisition, Trafficking, Deployment, and Storage in Mineral-Grown Methanogen Cells (2021) (6)
- [FeFe]-hydrogenase maturation: H-cluster assembly intermediates tracked by electron paramagnetic resonance, infrared, and X-ray absorption spectroscopy (2020) (5)
- Mechanism of Radical S-Adenosyl-l-methionine Adenosylation: Radical Intermediates and the Catalytic Competence of the 5'-Deoxyadenosyl Radical. (2022) (5)
- Characterization of the Preprocessed Copper Site Equilibrium in Amine Oxidase and Assignment of the Reactive Copper Site in Topaquinone Biogenesis. (2019) (5)
- Iron-Sulfur Cluster States of the Hydrogenase Maturase HydF. (2017) (4)
- HydG, the "dangler" iron, and catalytic production of free CO and CN-: implications for [FeFe]-hydrogenase maturation. (2021) (4)
- 23. Origin and evolution of Fe-S proteins and enzymes (2014) (3)
- The B12-independent glycerol dehydratase activating enzyme from Clostridium butyricum cleaves SAM to produce 5'-deoxyadenosine and not 5'-deoxy-5'-(methylthio)adenosine. (2021) (3)
- [FeFe]-Hydrogenase In Vitro Maturation. (2022) (3)
- Solution phase dynamics of the DNA repair enzyme spore photoproduct lyase as probed by H/D exchange (2014) (3)
- Biochemical and kinetic characterization of radical AdoMet enzyme HydG (3)
- Radical SAM enzymes: Nature's choice for radical reactions (2022) (2)
- [FeFe]‐Hydrogenase Cofactor Assembly (2013) (2)
- Faculty Opinions recommendation of Crystallographic and spectroscopic characterization of a nonheme Fe(IV)-O complex. (2003) (2)
- 17 Origin and evolution of Fe-S proteins and enzymes (2017) (2)
- Cutting Choline with Radical Scissors. (2016) (1)
- Radical SAM Enzymes and Their Roles in Complex Cluster Assembly (2015) (1)
- Paramagnetic Resonance in Mechanistic Studies of Fe-S/Radical Enzymes (2003) (1)
- [FeFe]-Hydrogenase: Defined Lysate-Free Maturation Reveals a Key Role for Lipoyl-H-Protein in DTMA Ligand Biosynthesis. (2022) (1)
- Bioinorganic chemistry. (2003) (1)
- Genome sequence of Desulfitobacterium hafnienseDCB-2, a Gram-positive anaerobe capable of dehalogenation and metal reduction (2012) (1)
- Faculty Opinions recommendation of Characterization of MOCS1A, an oxygen-sensitive iron-sulfur protein involved in human molybdenum cofactor biosynthesis. (2004) (1)
- Chemoselective Deprotection of Triethylsilyl Ethers. (2010) (0)
- Combined Mössbauer spectroscopic, multi-edge X-ray absorption spectroscopic, and density functional theoretical study of the radical SAM enzyme spore photoproduct lyase (2014) (0)
- Faculty Opinions recommendation of A metal-binding site in the catalytic subunit of anaerobic ribonucleotide reductase. (2003) (0)
- Faculty Opinions recommendation of Alkyl isocyanides serve as transition state analogues for ligand entry and exit in myoglobin. (2010) (0)
- Insights into Radical SAM Enzyme Mechanism from Lysine‐2,3‐aminomutase And An S‐ adenosyl‐L‐methionine Analog (2017) (0)
- Correction to [FeFe]-Hydrogenase Maturation (2014) (0)
- Abstract 2628: Characterization of a FeoC-like protein in Methanococcus voltae (2023) (0)
- Faculty Opinions recommendation of The PcoC copper resistance protein coordinates Cu(I) via novel S-methionine interactions. (2003) (0)
- Faculty Opinions recommendation of Very high-field EPR study of glycyl radical enzymes. (2003) (0)
- Mechanism of Radical Initiation in the Radical SAM Enzyme Superfamily. (2023) (0)
- Faculty Opinions recommendation of SufD and SufC ATPase activity are required for iron acquisition during in vivo Fe-S cluster formation on SufB. (2011) (0)
- Faculty Opinions recommendation of Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme. (2004) (0)
- [FeFe]-hydrogenase Oxygen Inactivation is Initiated by the Modification and Degradation of the H cluster 2Fe Subcluster (2015) (0)
- [FeFe]-hydrogenase maturation: H-cluster assembly intermediates tracked by electron paramagnetic resonance, infrared, and X-ray absorption spectroscopy (2020) (0)
- Spectroscopic Investigation of Pyruvate Formate Lyase-activating Enzyme: A Look into EPR, ENDOR and Mossabuer Spectroscopy (2014) (0)
- Faculty Opinions recommendation of Dioldehydrase: an essential role for potassium ion in the homolytic cleavage of the cobalt-carbon bond in adenosylcobalamin. (2007) (0)
- Abstract 1203: Characterization of a Novel Methanogen Radical SAM enzyme containing a SPASM Domain (2023) (0)
- Biochemical Characterization of HydF, a Scaffolding Enzyme, in the Synthesis of the Hydrogenase Active Site Metal Center: Implications Towards the Evolution of Biocatalysts from Mineral-Based Components on Early Earth (2010) (0)
- Exploring the Genome and Proteome of Desulfitobacterium hafniense DCB2 for its Protein Complexes Involved in Metal Reduction and Dechlorination (2012) (0)
- Faculty Opinions recommendation of Adenosyltransferase tailors and delivers coenzyme B12. (2008) (0)
- Faculty Opinions recommendation of Animal pigment bilirubin discovered in plants. (2009) (0)
- Mode of inhibitor binding in 0140 at-chlorocatechol dioxygenase (EI) complex: Structural and resonance raman studies of a model complex; [Fe(Cl4CAT)3]3− (1991) (0)
- Faculty Opinions recommendation of Crystal structure of naphthalene dioxygenase: side-on binding of dioxygen to iron. (2003) (0)
- H-Cluster assembly during maturation of the [FeFe]-hydrogenase (2014) (0)
- An Efficient Deprotection of N-Trimethylsilylethoxymethyl (SEM) Groups from Dinucleosides and Dinucleotides. (2010) (0)
- Faculty Opinions recommendation of The Elongator subunit Elp3 contains a Fe4S4 cluster and binds S-adenosylmethionine. (2006) (0)
- Abstract 1343: A Defined Lysate-Free in vitro [FeFe]-Hydrogenase Maturation (2023) (0)
- Mechanism and control in radical SAM enzymes (2017) (0)
- Unraveling the secrets of radical SAM mechanisms (2022) (0)
- 2014 METALS IN BIOLOGY GORDON RESEARCH CONFERENCE AND BIOINORGANIC CHEMISTRY GORDON RESEARCH SEMINAR (JANUARY 26-FEBRUARY 2, 2014 - FOUR POINTS SHERATON/HOLIDAY INN EXPRESS, VENTURA, CA) (2014) (0)
- Archives of Biochemistry and Biophysics (2014) (0)
- Faculty Opinions recommendation of Tyrosine 89 accelerates Co-carbon bond homolysis in methylmalonyl-CoA mutase. (2003) (0)
- 3P025 リジン 2,3-アミノミューターゼにおける高反応性ラジカル反 応機構の解明 Taming the Reactive 5’-Deoxyadenosyl Radical by Enforcing van der Waals Contact with Substrate in Lysine 2,3- Aminomutase (2014) (0)
- Poised for radical generation: Interaction of S-adenosylmethionine with a [4Fe4S] cluster (2003) (0)
- Biomining metals from pyritic ores: physiological, biochemical, and biophysical considerations (2022) (0)
- Faculty Opinions recommendation of Primordial synthesis of amines and amino acids in a 1958 Miller H2S-rich spark discharge experiment. (2011) (0)
- Faculty Opinions recommendation of A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase. (2002) (0)
- Faculty Opinions recommendation of GTP is required for iron-sulfur cluster biogenesis in mitochondria. (2008) (0)
- 11 Catechol dioxygenases (2003) (0)
- Radical S-Adenosyl-l-Methionine Enzymes (2021) (0)
- I. Biogenesis of metalloproteins (2009) (0)
- Faculty Opinions recommendation of Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase. (2004) (0)
- Faculty Opinions recommendation of Probing nitrogen-sensitive steps in the free-radical-mediated deamination of amino alcohols by ethanolamine ammonia-lyase. (2006) (0)
- Faculty Opinions recommendation of Nitrilotriacetic acid-modified magnetic nanoparticles as a general agent to bind histidine-tagged proteins. (2004) (0)
- Role of Fe-S Cluster Mediated Radical Chemistry in Hydrogenase Metal Cluster Assembly. (2010) (0)
- Faculty Opinions recommendation of Self-repair of thymine dimer in duplex DNA. (2007) (0)
- Proteomic Analysis of Methanococcus voltae Grown in the Presence of Mineral and Nonmineral Sources of Iron and Sulfur (2022) (0)
- 3P025 Taming the Reactive 5'-Deoxyadenosyl Radical by Enforcing van der Waals Contact with Substrate in Lysine 2,3-Aminomutase(01A. Protein: Structure,Poster) (2013) (0)
- Biogenesis of the H‐cluster of the [FeFe]‐hydrogenase (2013) (0)
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