Joan Brugge

Q: What Schools Are Affiliated With Joan Brugge

Joan Brugge is affiliated with the following schools: Washington University in St. Louis, Stony Brook University, Icahn School of Medicine at Mount Sinai, Northwestern University, University of Pennsylvania, Harvard University

Joan Brugge's AcademicInfluence.com Rankings

Joan Brugge

Biology

#1914

World Rank

#3096

Historical Rank

#898

USA Rank

Cell Biology

#57

World Rank

#61

Historical Rank

#27

USA Rank

biology Degrees

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Biology

Why Is Joan Brugge Influential?

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According to Wikipedia, Joan S. Brugge is the Louise Foote Pfeiffer Professor of Cell Biology and the Director of the Ludwig Center at Harvard Medical School, where she also served as the Chair of the Department of Cell Biology from 2004 to 2014. Her research focuses on cancer biology, and she has been recognized for her explorations into the Rous sarcoma virus, extracellular matrix adhesion, and epithelial tumor progression in breast cancer.

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Joan Brugge's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Integrins and signal transduction pathways: the road taken. (1995) (3095)
Cellular functions regulated by Src family kinases. (1997) (2519)
Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. (2003) (1979)
Modelling glandular epithelial cancers in three-dimensional cultures (2005) (1061)
A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen. (2004) (961)
Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis (2011) (942)
Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases (1992) (934)
Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment (2009) (896)
Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon (2006) (893)
Sensing the environment: a historical perspective on integrin signal transduction (2002) (855)
The Role of Apoptosis in Creating and Maintaining Luminal Space within Normal and Oncogene-Expressing Mammary Acini (2002) (802)
Identification of a transformation-specific antigen induced by an avian sarcoma virus (1977) (789)
Engineering tumors with 3D scaffolds (2007) (787)
Mutant p53 Drives Invasion by Promoting Integrin Recycling (2009) (761)
Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets (1992) (666)
Integrin-mediated Signals Regulated by Members of the Rho Family of GTPases (1998) (660)
Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation (1995) (637)
Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases (1992) (624)
ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini (2001) (598)
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial–mesenchymal transition (2005) (594)
Src kinase activation by direct interaction with the integrin β cytoplasmic domain (2003) (579)
A Nonapoptotic Cell Death Process, Entosis, that Occurs by Cell-in-Cell Invasion (2007) (565)
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis (2003) (542)
Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. (2005) (492)
The PHD Finger of the Chromatin-Associated Protein ING2 Functions as a Nuclear Phosphoinositide Receptor (2003) (489)
Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation (1997) (460)
p63 regulates an adhesion programme and cell survival in epithelial cells (2006) (431)
Identification of genes that regulate epithelial cell migration using an siRNA screening approach (2008) (425)
Signal transduction in cancer. (2015) (422)
Coordinate interactions of Csk, Src, and Syk kinases with αIIbβ3 initiate integrin signaling to the cytoskeleton (2002) (404)
Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets. (1991) (398)
YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway (2009) (390)
Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals. (2013) (389)
Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses (1983) (388)
Controlled Dimerization of ErbB Receptors Provides Evidence for Differential Signaling by Homo- and Heterodimers (1999) (379)
Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells. (2012) (362)
Oncogene-like induction of cellular invasion from centrosome amplification (2014) (358)
Neurones express high levels of a structurally modified, activated form of pp60c-src (1985) (329)
Solution structure of the SH3 domain of Src and identification of its ligand-binding site. (1992) (315)
The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins (1981) (312)
Tyrosine phosphorylation and cytoskeletal reorganization in platelets are triggered by interaction of integrin receptors with their immobilized ligands. (1993) (285)
Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and transformation (1984) (276)
Role of simian virus 40 gene A function in maintenance of transformation (1975) (270)
IL-6 involvement in epithelial cancers. (2007) (269)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro. (2004) (268)
Calcium influx induces neurite growth through a Src-Ras signaling cassette (1995) (267)
Neural tissues express high levels of the cellular src gene product pp60c-src (1983) (267)
Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility (2012) (259)
Vav Family GEFs Link Activated Ephs to Endocytosis and Axon Guidance (2005) (255)
BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. (2007) (254)
Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains (1994) (253)
Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells. (2004) (252)
Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity. (1986) (250)
A 90,000-dalton binding protein common to both steroid receptors and the Rous sarcoma virus transforming protein, pp60v-src. (1985) (248)
Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells (2003) (246)
Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions (1991) (246)
Ovarian cancer spheroids use myosin-generated force to clear the mesothelium. (2011) (245)
A new mutational AKTivation in the PI3K pathway. (2007) (245)
pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) signaling in breast cancer cells. (1999) (244)
Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338 (2000) (244)
Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors. (1994) (243)
Vav GEFs are required for β2 integrin-dependent functions of neutrophils (2004) (238)
Identification of Src, Fyn, Lyn, PI3K and Abl SH3 domain ligands using phage display libraries. (1994) (238)
Role of platelet membrane glycoprotein IIb-IIIa in agonist-induced tyrosine phosphorylation of platelet proteins (1990) (233)
On the role of the platelet membrane skeleton in mediating signal transduction. Association of GP IIb-IIIa, pp60c-src, pp62c-yes, and the p21ras GTPase-activating protein with the membrane skeleton. (1993) (225)
Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets (1993) (224)
Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3. (1994) (223)
Adhesive signaling in platelets. (1994) (220)
Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets. (1989) (217)
Outgrowth of Single Oncogene-expressing Cells from Suppressive Epithelial Environments (2012) (216)
Detection of Src homology 3-binding proteins, including paxillin, in normal and v-Src-transformed Balb/c 3T3 cells. (1993) (212)
Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1 (1998) (209)
Interaction of the Rous sarcoma virus protein pp60src with the cellular proteins pp50 and pp90. (1986) (209)
Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells. (2016) (208)
Syk Is Activated by Phosphotyrosine-containing Peptides Representing the Tyrosine-based Activation Motifs of the High Affinity Receptor for IgE(*) (1995) (207)
Identification of a polypeptide encoded by the avian sarcoma virus src gene. (1978) (206)
Common effector processing mediates cell-specific responses to stimuli (2007) (205)
Characterization of a normal avian cell protein related to the avian sarcoma virus transforming gene product (1978) (190)
Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis. (2006) (186)
Phage display selection of ligand residues important for Src homology 3 domain binding specificity. (1995) (182)
Adhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK (1993) (180)
Epidermal Growth Factor Receptor-Dependent Regulation of Integrin-Mediated Signaling and Cell Cycle Entry in Epithelial Cells (2004) (179)
Leukemia inhibitory factor and interleukin-6 trigger the same immediate early response, including tyrosine phosphorylation, upon induction of myeloid leukemia differentiation (1991) (175)
MYC regulation of a “poor-prognosis” metastatic cancer cell state (2010) (173)
Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. (2011) (173)
Activation of Syk protein tyrosine kinase through interaction with integrin β cytoplasmic domains (2001) (171)
Vav Family Proteins Couple to Diverse Cell Surface Receptors (2000) (167)
Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src (1992) (166)
Regulation of protein tyrosine kinases in platelets. (1994) (166)
Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner (2003) (165)
Regulation of the pp72syk protein tyrosine kinase by platelet integrin αIIbβ3 (1997) (165)
The cell biology of cell-in-cell structures (2008) (165)
Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers (2017) (158)
Activation of Fc gamma RII induces tyrosine phosphorylation of multiple proteins including Fc gamma RII. (1992) (158)
Chaperone-mediated autophagy degrades mutant p53. (2013) (156)
Bim Regulation of Lumen Formation in Cultured Mammary Epithelial Acini Is Targeted by Oncogenes (2005) (155)
Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis (2007) (154)
Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours (2015) (154)
Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells (2010) (153)
Interaction between the Rous sarcoma virus transforming protein and two cellular phosphoproteins: analysis of the turnover and distribution of this complex (1983) (152)
Use of Three-Dimensional Basement Membrane Cultures to Model Oncogene-Induced Changes in Mammary Epithelial Morphogenesis (2004) (151)
Leukocyte protein tyrosine kinases: potential targets for drug discovery. (1997) (151)
Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance. (2018) (151)
A normal cell protein similar in structure and function to the avian sarcoma virus transforming gene product. (1979) (150)
A non-genetic route to aneuploidy in human cancers (2011) (147)
The structurally distinct form of pp60c-src detected in neuronal cells is encoded by a unique c-src mRNA (1987) (144)
Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion. (2012) (144)
Protein tyrosine phosphorylation and the adhesive functions of platelets. (1991) (139)
G1/S Cell Cycle Arrest Provides Anoikis Resistance through Erk-Mediated Bim Suppression (2005) (132)
Structure-function analysis of SH3 domains: SH3 binding specificity altered by single amino acid substitutions (1995) (129)
Cycling cancer persister cells arise from lineages with distinct programs (2021) (129)
Lumen formation during mammary epithelial morphogenesis: insights from in vitro and in vivo models (2008) (129)
A structure-guided approach to creating covalent FGFR inhibitors. (2010) (127)
Overview of the Alliance for Cellular Signaling (2002) (125)
Protein Kinase C Regulates Integrin-induced Activation of the Extracellular Regulated Kinase Pathway Upstream of Shc* (1999) (123)
A stiff blow from the stroma: collagen crosslinking drives tumor progression. (2009) (122)
Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression (2011) (116)
The p35 p36 substrates of protein-tyrosine kinases as inhibitors of phospholipase A2 (1986) (115)
Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture (2004) (115)
Identifying single-cell molecular programs by stochastic profiling (2010) (111)
Tyrosine phosphorylation of a gap junction protein correlates with inhibition of cell-to-cell communication. (1990) (109)
Induction of altered c-src product during neural differentiation of embryonal carcinoma cells. (1986) (104)
Protein tyrosine kinases Syk and ZAP-70 display distinct requirements for Src family kinases in immune response receptor signal transduction. (1997) (104)
p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated platelets. (1992) (103)
Association of the transforming proteins of Rous, Fujinami, and Y73 avian sarcoma viruses with the same two cellular proteins (1982) (103)
Mapping the dynamics of force transduction at cell–cell junctions of epithelial clusters (2014) (102)
Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance. (2014) (101)
Rapid Sequential in Situ Multiplexing with DNA Exchange Imaging in Neuronal Cells and Tissues. (2017) (97)
Novel role for PDEF in epithelial cell migration and invasion. (2005) (93)
New intracellular targets for therapeutic drug design. (1993) (93)
Origins of human cancer : a comprehensive review (1991) (92)
Molecular events in cells transformed by Rous Sarcoma virus (1980) (88)
Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics (2016) (87)
Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages (2020) (86)
Activity of the multikinase inhibitor dasatinib against ovarian cancer cells (2009) (85)
Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. (2019) (83)
Phosphorylation of c-Src on tyrosine 527 by another protein tyrosine kinase. (1991) (83)
Regulation of Cell Adhesion and Collective Cell Migration by Hindsight and Its Human Homolog RREB1 (2008) (80)
Thrombin Receptor Activation and Integrin Engagement Stimulate Tyrosine Phosphorylation of the Proto-oncogene Product, p95, in Platelets (*) (1996) (79)
Starved epithelial cells uptake extracellular matrix for survival (2017) (78)
Akt and ERK Control the Proliferative Response of Mammary Epithelial Cells to the Growth Factors IGF-1 and EGF Through the Cell Cycle Inhibitor p57Kip2 (2012) (77)
Clustering of Syk is sufficient to induce tyrosine phosphorylation and release of allergic mediators from rat basophilic leukemia cells (1995) (75)
PTK6 Regulates IGF-1-Induced Anchorage-Independent Survival (2010) (75)
A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth (2004) (75)
3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis. (2020) (72)
Functional proteomics approach to investigate the biological activities of cDNAs implicated in breast cancer. (2006) (70)
Fibroblast growth factor receptor 1-transformed mammary epithelial cells are dependent on RSK activity for growth and survival. (2009) (70)
Characterization of the altered form of the c-src gene product in neuronal cells. (1987) (67)
Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer. (2020) (67)
Extracellular matrix regulation of metabolism and implications for tumorigenesis. (2011) (65)
Peptide analysis of the transformation-specific antigen from avian sarcoma virus-transformed cells (1978) (65)
Mutation of a termination codon affects src initiation (1984) (64)
Protein phosphorylation mediated by partially purified avian sarcoma virus transforming-gene product. (1980) (64)
Rous sarcoma virus-induced phosphorylation of a 50,000-molecular weight cellular protein (1982) (62)
Expression of Rous sarcoma virus transforming protein pp60v-src in Saccharomyces cerevisiae cells (1987) (62)
Expression Cloning of Protein Targets for 3-Phosphorylated Phosphoinositides* (1999) (61)
PDEF promotes luminal differentiation and acts as a survival factor for ER-positive breast cancer cells. (2013) (59)
Analysis of the catalytic domain of phosphotransferase activity of two avian sarcoma virus-transforming proteins. (1984) (59)
Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation (1991) (56)
Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3. (1997) (55)
ErbB2 Stabilizes Epidermal Growth Factor Receptor (EGFR) Expression via Erk and Sprouty2 in Extracellular Matrix-detached Cells*♦ (2010) (53)
Phosphorylated and nonphosphorylated forms of avian sarcoma virus polypeptide p19. (1977) (53)
Tyrosine phosphorylation within the amino-terminal domain of pp60c-src molecules associated with polyoma virus middle-sized tumor antigen. (1985) (53)
Deletions within the amino-terminal half of the c-src gene product that alter the functional activity of the protein (1989) (52)
p63, Cell Adhesion and Survival (2007) (52)
Structurally distinct disintegrins contortrostatin and multisquamatin differentially regulate platelet tyrosine phosphorylation. (1994) (52)
Long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids (2021) (51)
Characterization of the avian sarcoma virus protein p60src. (1978) (49)
ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP. (2016) (49)
Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP (2016) (48)
Cancer: The enemy of my enemy is my friend (2015) (48)
Activation of NF-κB following detachment delays apoptosis in intestinal epithelial cells (2005) (48)
Circulating colony stimulating factor-1 and breast cancer risk. (2008) (46)
Detection of phosphotyrosine-containing proteins in polyomavirus middle tumor antigen-transformed cells after treatment with a phosphotyrosine phosphatase inhibitor (1987) (43)
Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition. (2016) (42)
Tumor Self-Seeding: Bidirectional Flow of Tumor Cells (2009) (42)
Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells (2017) (42)
The Role of Proliferation in Determining Response to Neoadjuvant Chemotherapy in Breast Cancer: A Gene Expression–Based Meta-Analysis (2016) (41)
Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing (2020) (40)
Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response (2017) (40)
Induction of tumor formation and cell transformation by polyoma middle T antigen in the absence of Src. (1993) (38)
In vitro mesothelial clearance assay that models the early steps of ovarian cancer metastasis. (2012) (37)
Biological and biochemical properties of the c-src+ gene product overexpressed in chicken embryo fibroblasts (1989) (37)
Psidin, a conserved protein that regulates protrusion dynamics and cell migration. (2011) (37)
A major cytoplasmic glucose-regulated protein is associated with the Rous sarcoma virus pp60src protein. (1982) (36)
Investigation of factors that influence phosphorylation of pp60c-src on tyrosine 527 (1988) (36)
Increased expression of the src proto-oncogene in hairy cell leukemia and a subgroup of B-cell lymphomas. (1993) (36)
Detection of the Viral Sarcoma Gene Product in Cells Infected with Various Strains of Avian Sarcoma Virus and of a Related Protein in Uninfected Chicken Cells (1979) (36)
Characterization of structural domains of the human epidermal growth factor receptor obtained by partial proteolysis. (1984) (35)
Characterization of simian cells tranformed by temperature-sensitive mutants of simian virus 40 (1976) (34)
Therapy resistance: opportunities created by adaptive responses to targeted therapies in cancer (2022) (34)
Cloning and characterization of a thermolabile v-src gene for use in reversible transformation of mammalian cells. (1992) (33)
pp60src tyrosine kinase modulates P19 embryonal carcinoma cell fate by inhibiting neuronal but not epithelial differentiation (1992) (31)
Tyrosine phosphorylation in platelets Potential roles in intracellular signal transduction. (1993) (30)
ErbB2 and TGF-beta: A Cooperative Role in Mammory Tumor Progression? (2004) (30)
Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient–Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness (2019) (30)
Transformation of primate and rodent cells by temperature-sensitive mutants of SV40. (1975) (30)
Activation of NF-kappaB following detachment delays apoptosis in intestinal epithelial cells. (2005) (29)
Pathologic and molecular responses to neoadjuvant trastuzumab and/or lapatinib from a phase II randomized trial in HER2-positive breast cancer (TRIO-US B07) (2020) (29)
Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference (2019) (29)
Casting light on focal adhesions (1998) (28)
An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligand (2006) (27)
Role for polo-like kinase 4 in mediation of cytokinesis (2019) (27)
Direct phosphorylation of focal adhesion kinase by c-Src: evidence using a modified nucleotide pocket kinase and ATP analog. (2002) (26)
The src gene product of transformed and morphologically reverted ASV-infected mammalian cells (1979) (26)
Unregulated ARF6 Activation in Epithelial Cysts Generates Hyperactive Signaling Endosomes and Disrupts Morphogenesis (2010) (25)
Thrombin-stimulated immunoprecipitation of phosphatidylinositol 3-kinase from human platelets. (1990) (24)
Large-scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines (2020) (24)
Analysis of mutant forms of the c-src gene product containing a phenylalanine substitution for tyrosine 416. (1990) (24)
Evidence for a multipotent mammary progenitor with pregnancy-specific activity (2013) (23)
The role of SV40 gene A in the alteration of microfilaments in transformed cells. (1977) (23)
Cooperation of the ErbB 2 receptor and transforming growth factor in induction of migration and invasion in mammary epithelial cells (2004) (23)
YB-1 translational control of epithelial-mesenchyme transition. (2009) (23)
Virus-specific RNA species present in the cytoplasm of Rous sarcoma virus-infected chicken cells. (1977) (23)
Widespread distribution of the c-src gene product in nerve cells and axon terminals in the adult rat brain. (1988) (22)
Tensins: a new switch in cell migration. (2007) (21)
Uncovering a Tumor Suppressor for Triple-Negative Breast Cancers (2011) (21)
Differentiation and transformation of neural plate cells. (1984) (21)
Profiling Y561-Dependent and -Independent Substrates of CSF-1R in Epithelial Cells (2010) (20)
pp60v- src Induction of Cyclin D1 Requires Collaborative Interactions between the Extracellular Signal-regulated Kinase, p38, and Jun Kinase Pathways (1999) (20)
Vav 1 / 2 / 3-null mice define an essential role for vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells (2003) (20)
United They Stand, Divided They Fall. (2019) (20)
Morphological revertants of an avian sarcoma virus-transformed mammalian cell line exhibit tumorigenicity and contain pp60src. (1979) (19)
Transcriptional regulation of metastatic [Id]entity by KLF17 (2009) (18)
A protein interaction map for cell-cell adhesion regulators identifies DUSP23 as a novel phosphatase for β-catenin (2016) (18)
Antibody to virion structural proteins in mammals bearing avian sarcoma virus-induced tumors. (1978) (18)
Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo (2017) (18)
Transient commensal clonal interactions can drive tumor metastasis (2020) (17)
Fibroblast–tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways (2020) (17)
Fibroblast growth factor receptor 1-transformed mammary epithelial cells are dependent on RSK activity for growth and survival (Cancer Research (2009) 69 (2244-2251)) (2009) (16)
Neutralization of BCL-2/XL Enhances the Cytotoxicity of T-DM1 In Vivo (2019) (16)
The myosin-II-responsive focal adhesion proteome: a tour de force? (2011) (16)
Identification of cancer genes that are independent of dominant proliferation and lineage programs (2017) (15)
Cell regulation: Intracellular networking (1999) (14)
Faculty Opinions recommendation of Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. (2001) (14)
Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer (2020) (14)
Changes in the pattern of expression of pp60c‐src in cerebellar mutants of mice (1987) (13)
Expression of the Rous sarcoma virus src gene in avian macrophages fails to elicit transformed cell phenotype (1984) (13)
The distribution of virus-specific RNA in Rous sarcoma virus-induced hamster tumor cells. (1977) (12)
Phenotypic and genetic alterations in pre-cancerous cells in the colon. (1988) (12)
Membrane glycoprotein IV ( CD 36 ) is physically associated with the Fyn , Lyn , and Yes protein-tyrosine kinases in human platelets ( FYN / YES / LYN / SRC ) (12)
A human breast atlas integrating single-cell proteomics and transcriptomics. (2022) (11)
Cycling cancer persister cells arise from lineages with distinct transcriptional and metabolic programs (2020) (11)
Adhesive Ligand Binding to Integrin XXb/ 3 Stimulates Tyrosine Phosphorylation of Novel Protein Substrates before Phosphorylation of pp125 FAK (2002) (11)
Aging-associated alterations in the mammary gland revealed by single-cell RNA sequencing (2019) (9)
SePARating polarity and proliferation in ErbB2 oncogenesis (2006) (7)
Analysis of cDNAs of the proto-oncogene c-src: heterogeneity in 5' exons and possible mechanism for the genesis of the 3' end of v-src (1991) (7)
Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics (2021) (7)
Metabolic changes promote rejection of oncogenic cells (2017) (6)
Correction: Mapping the dynamics of force transduction at cell–cell junctions of epithelial clusters (2015) (6)
Corrigendum: Chaperone-mediated autophagy degrades mutant p53. (2016) (6)
Expression of the src-gene product, pp60src, in transformed and reverted mammalian cells infected with avian sarcoma virus. (1980) (5)
Investigations of the expression of the cellular src gene product. (1986) (5)
Coping with the metabolic stress of leaving home (2016) (5)
Into the deep: Refocusing on 3D (2012) (5)
AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer (2022) (5)
July 2004 (2004) (4)
Protein:protein interactions involved in intracellular signal transduction (1994) (4)
Studies on the structure and function of the avian sarcoma virus transforming gene product. (1979) (4)
Chapter 22. Tyrosine-Specific Protein Kinases (1983) (4)
Abstract P4-08-05: Basement membrane localized tumor cells are protected from HER2-targeted therapy in vivo. (2012) (4)
Clinical evaluation of BCL-2/XL levels pre- and post- HER2-targeted therapy (2021) (4)
[Entosis, a cell death process related to cell cannibalism between tumor cells]. (2008) (4)
Rapid Sequential in Situ Multiplexing With DNA-Exchange-Imaging (2017) (3)
Mechanistic Biology in the Next Quarter Century (2010) (3)
Abstract PR06: Contribution of mutant microenvironment to hereditary cancer: Single-cell gene expression profiling of a genetically engineered mouse model of human hereditary BRCA1-related breast cancer (2018) (3)
Discovery of new gene expression predictors for adjuvant tamoxifen outcome for breast cancer patients. (2004) (3)
Clonal populations of a human TNBC model display significant functional heterogeneity and divergent growth dynamics in distinct contexts (2021) (3)
Live free or die: cell-cell adhesion regulates sensitivity to trail-induced apoptosis. (2014) (3)
The association of the transforming protein of Rous sarcoma virus with two cellular phosphoproteins. (1983) (2)
Blood platelets express high levels of the pp 60 Ocsrcspeciflc tyrosine kinase activity (2)
Abstract 884: Interplay between NRF2 and GPX4 is critical for cancer cell survival in 3D spheroids (2019) (2)
Protein Tyrosine Phosphorylation in Platelets (1997) (2)
Program and abstracts for the 2012 Joint Meeting of the Society for Glycobiology & American Society for Matrix Biology (2012) (2)
Comparison of the Structural and Functional Properties of the Viral and Cellular src Gene Products (1987) (2)
Discovery of new gene expression predictors for adjuvant tamoxifen outcome for breast cancer patients (2004) (1)
Abstract 342: Development and characterization of a novel anti-CLDN6 antibody drug conjugate for the treatment of CLDN6 positive cancers (2022) (1)
Abstract 4836: Inhibition of PI3K/mTOR leads to adaptive resistance in extracellular matrix attached cancer cells (2012) (1)
Abstract 4946: Control of cellular proliferation by ERK: A quantitative analysis in single cells (2012) (1)
Transforming gene product of avian sarcoma viruses and its homolog in uninfected cells. (1980) (1)
Oncogenic in Mammary Epithelial Cells Mutations Are PIK 3 CA Associated − Breast Cancer (2005) (1)
Uncovering a Tumor Suppressor for Triple-Negative Breast Cancers (2011) (1)
Investigation of Factors That Influence Phosphorylation of pp6Ocsrc on Tyrosine 527 (1)
CRB3 and the FERM protein EPB41L4B regulate proliferation of mammary epithelial cells through the release of amphiregulin (2018) (1)
DL1-1: Adaptive Resistance to Targeted Therapies. (2011) (0)
Abstract 5478: The TRPA1 Ca2+-permeable channel mediates a non-canonical redox adaptation in cancer cells (2017) (0)
Abstract PR12: Mutant p53 drives early events in fallopian tube tumorigenesis through mesenchyme-associated autocrine production of matrix that supports survival and mesothelial intercalation. (2016) (0)
Abstract CT142: TALAVE: Induction talazoparib (tala) followed by combined tala and avelumab in patients (pts) with advanced breast cancer (ABC) (2023) (0)
Erratum: Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo (2017) (0)
Erratum: Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo (2017) (0)
Abstract PR7: Visualizing the dynamic and heterogeneous responses of single cells to inhibitors of the growth factor signaling network (2012) (0)
At the leading edge of cancer research: an interview with Joan Brugge (2011) (0)
Bim regulation or lumen formation in epithelial acini is blocked by oncogenes (2002) (0)
Quantifying Mechanical Interactions between Cells in Small Clusters (2011) (0)
Abstract 4985: Understanding the vulnerabilities in cancer cells upon inhibition of glutathione synthesis (2017) (0)
General Discussion .2. Regulation of the Eukaryotic Cell-Cycle (1990) (0)
Preclinical Efficacy of the Antibody-Drug-Conjugate CLDN6-23-ADC for the Treatment of CLDN6 Positive Solid Tumors. (2023) (0)
Abstract 2802: Evaluation of metabolic changes induced by loss of extracellular matrix attachment using 13C Flux analysis (2011) (0)
Integrin-induced EGFR activation and control of the cell cycle in epithelial cells (2003) (0)
Abstract 3155: Loss of YAP1 dysregulates RhoA signaling and promotes cell invasion (2018) (0)
Abstract 1851: Combined inhibition of PARP and the unfolded protein response synergistically reduces viability in BRCA1-mutant breast cancer cells (2018) (0)
Association oftheTransforming Proteins ofRous,Fujinami, andY73AvianSarcoma Viruses withtheSameTwoCellular Proteins (1982) (0)
Abstract P5-17-01: Patient-derived organoid models of inflammatory breast cancer (2019) (0)
Abstract 1540: Targeting PI3K/mTOR inhibitor induced survival programs abrogates resistance to cell death in ECM-attached cancer cells (2011) (0)
Abstract WS2-1: Drug-tolerant persister cells in cancer (2023) (0)
Biographical Feature: Marc S. Collett (23 May 1951–11 June 2022): the Battle against Viral Disease Has Lost a Valiant Warrior, and the World Has Lost a Splendid Human Being (2022) (0)
Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response (2017) (0)
Erratum: Uncovering a tumor suppressor for triple-negative breast cancers (Cell (Mar 2011) 144 (638-640)) (2011) (0)
TITLE : Experimental Analysis and Computational Modeling of Network States and Drug Responses in the PI 3 K / Akt / mTOR Network (2009) (0)
Moving Closer To Victory. (2016) (0)
Abstract 2976: Intratumoral cellular heterogeneity of epithelial ovarian carcinoma and its impact on tumor behavior (2014) (0)
Isolation ofMonoclonal Antibodies ThatRecognize the Transforming Proteins ofAvianSarcoma Viruses (1983) (0)
Abstract ES6-1: Oxidative stress responses in cancer (2019) (0)
Activity of combination trametinib/navitoclax in patients with RAS-mutated gynecologic (GYN) cancers in a Phase 1/2 study (LBA 12) (2022) (0)
and Collective Cell Migration Supplemental Data S 1 Regulation of Cell Adhesion by Hindsight and Its Human Homolog RREB 1 (0)
Abstracts of papers presented at the Cold Spring Harbor Meeting on Cancer Cells : Origins of Human Cancer, September 5-September 11, 1990 (1990) (0)
Abstract 969: Characterization of murine mammary epithelial populations throughout development and in premalignant tissue via mass cytometry (2019) (0)
Abstract PR03: The Hippo pathway effector YAP1 contributes to escape from proliferation arrest under chronic PI3K/mTOR inhibition (2015) (0)
Synergistic combination therapy delivered via layer‐by‐layer nanoparticles induces solid tumor regression of ovarian cancer (2022) (0)
Overcoming Tumor Diversity and Adaptability Key to Effective Therapies in BC (2014) (0)
Cathepsin g is not a specific agonist for protease activated receptors in platelets (2007) (0)
Critical Questions in Ovarian Cancer Research and Treatment: Report of an AACR Special Conference (2019) (0)
Expression of the C-SRC Proto-Oncogene Product in Neural Cells (1988) (0)
Entry in Epithelial Cells Integrin-Mediated Signaling and Cell Cycle Receptor-Dependent Regulation of Epidermal Growth Factor (2004) (0)
Abstract P4-10-12: Characterizing the tumor and immune microenvironment through treatment to predict response to neoadjuvant HER2-targeted therapy using the Digital Spatial Profiler (2020) (0)
Science Signaling Podcast: 6 March 2012 (2012) (0)
Tyrosine phosphorylation within the amino-terminal domain of pp 6 Oc-src molecules associated with polyoma virus middle-sized tumor antigen ( trandormation / tyroulne protein kinase / ceilular oncogene / tumor virus / sodium orthovanadate ) (0)
Abstract 3843: Design of effective combination therapies for high-grade serous ovarian cancer using patient-derived xenograft models (2016) (0)
Abstract 989: Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages and can form chimeric mammary glands in vivo (2018) (0)
Abstract 4751: Identification of mechanism involved in mesothelial clearance by ovarian tumor spheroids (2011) (0)
Rab25 Mediates Integrin Recycling for Tumor Cell Migration in 3D (2011) (0)
Abstract P4-14-02: Neutralization of BCL2/BCL-XL enhances the cytotoxicity of T-DM1 in vivo (2016) (0)
Altered metabolic requirements in cancer cell migration and metastasis (2012) (0)
Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer (2020) (0)
Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages (2020) (0)
Fibroblast Growth Factor Receptor 1–TransformedMammary Epithelial Cells Are Dependent on RSK Activity for Growth and Survival (2009) (0)
Abstract A7: Targeting mutant p53 and cell-cell adhesion in ovarian cancer (2013) (0)
Abstract P5-01-02: Single cell RNA transcriptomics reveals tumor promoting mammary cell subpopulation upon replication stress in BRCA1 mutant breast cancer mouse model (2022) (0)
Evidence for a multipotent mammary progenitor with pregnancy-specific activity (2013) (0)
The BRCA1 isoform, BRCA1-IRIS, operates independently of the full-length BRCA1 in the Fanconi anemia pathway (2022) (0)
Abstract 3301: Using a novel single-cell lineage-tracing technique to uncover the mechanisms driving nongenetic cancer relapse (2018) (0)
2 p 57 Cells to the Growth Factors IGF-1 and EGF Through the Cell Cycle Inhibitor Akt and ERK Control the Proliferative Response of Mammary Epithelial (2012) (0)
Abstract PR01: Adaptive resistance of patient-derived ovarian cancer cells to PI3K/mTOR inhibition (2015) (0)
Meta-analysis of breast cancer expression data using published gene signatures to reveal key cellular processes implicated in chemosensitivity and resistance. (2015) (0)
Abstract PD7-03: A living biobank of normal mammary organoids derived from patients at low and increased risk of developing breast cancer (2021) (0)
Abstract B48: Design of effective combination therapies for high-grade serous ovarian cancer using patient-derived xenograft models. (2016) (0)
Abstract LB-418: A live-cell miRNA reporter library for identifying non-genetic drug resistance networks at single-cell resolution (2012) (0)
Abstract IA-13: Mechanisms regulating anchorage independent survival (2009) (0)
Abstract 2978: Clinical evaluation of lapatinib induced BCL-2 adaptive responses (2019) (0)
Abstract #4410: Rescue of extracellular matrix detachment induced metabolic defects by ErbB2 and antioxidants (2009) (0)
Abstract P4-07-01: Tumor expression and microenvironment in HER2-positive breast cancer before and on HER2-targeted therapy: Analysis of microarray expression data from the TRIO-US B07 trial (2020) (0)
Abstract 3957: Characterization of functional heterogeneity andin vivodynamics of clonal cell populations derived from the triple-negative breast cancer cell line MDA-MB-468 (2017) (0)
Abstract P3-07-31: Immune activation signatures identify a subset of ER+ breast cancers with increased pathologic complete response to neoadjuvant chemotherapy (2016) (0)
Abstract PR09: Cellular heterogeneity of ovarian carcinoma cells and its impact on tumor behavior (2013) (0)
Engineering Cell Culture Models to Study Morphogenesis & Oncogenesis (2010) (0)
Abstract 11: Prophylactic use of tamoxifen could reduce the risk of breast cancer in women who do not breast feed postpartum (2022) (0)
Abstract PR01: Systems analysis of signaling pathway adaptation to design effective PI3K-based combination therapies using ovarian cancer patient-derived xenografts (2017) (0)
Abstract OT1-1-07: Phase II trial of paclitaxel combined with trastuzumab and pertuzumab as preoperative therapy for HER2 positive inflammatory breast cancer (2013) (0)
A transcriptional response to replication stress selectively expands a subset of BRCA2-mutant mammary epithelial cells (2022) (0)
Abstract A132: Characterization of intratumoral heterogeneity in drug sensitivity and non-cell autonomous mechanisms of drug resistance using subclonal cell populations derived from a single breast cancer cell line (2019) (0)
Single Cell Transcriptomics identifies a WNT7A-FZD5 Signaling Axis that maintains Fallopian Tube Stem Cells in Patient-derived Organoids (2023) (0)
Abstract 2140: Mesenchymal stromal cells expressing a PEAK1/Cripto axis sustain pro-survival NF-κB signaling in adjacent tumor cells to promote disease progression and therapy resistance (2018) (0)
Abstract P3-11-06: Pre-clinical assessment of combined ABT-263/Navitoclax and ABT-414 or ABBV-321 treatment for EGFR-expressing TNBC (2020) (0)
Abstract 2736: Regulation of cytokinesis by polo-like kinase 4 (2016) (0)
Abstract #LB-272: A novel dose-dependent regulation of matrix adhesion by Notch that controls outgrowth of hyperproliferative structures (2009) (0)
Q&A: Joan Brugge on empowering post-docs. (2012) (0)
Characterization of Mammary Cells Co‐expressing Separate Lineage Markers (2020) (0)
Abstract 4451: Long-term resistance to PI3K/mTOR inhibition requires increased expression of c-myc and YAP. (2013) (0)
Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo (2017) (0)
Abstract LB-228: YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway (2009) (0)
Abstract 3775: Characterization of intratumoral heterogeneity in drug sensitivity and modeling of drug combination effects using subclonal cell populations derived from a single breast cancer cell line (2019) (0)
Abstract 3459: Drug persistence pathways in ovarian cancer identified by single-cell analysis of patient samples and cell line models (2023) (0)
Abstract 4033: Combined MEK and BCL-2/XLinhibition as a potential drug combination for the treatment of high-grade serous ovarian cancer (2017) (0)
Abstract 2101: Targeting the root of cancer persister cells using an expressed barcode library (2019) (0)
Identification of a polypeptide enc( sarcoma virus src gene (cell-free protein synthesis/translation of viral RNA/immunopre4 (2016) (0)

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What Schools Are Affiliated With Joan Brugge?

Joan Brugge is affiliated with the following schools: