Joan Heller Brown

Joan Heller Brown's AcademicInfluence.com Rankings

Joan Heller Brown

Medical

#1295

World Rank

#1621

Historical Rank

Pharmacology

#94

World Rank

#122

Historical Rank

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Medical

Joan Heller Brown's Degrees

PhD Pharmacology University of California, San Francisco
Bachelors Pharmacy University of California, San Francisco

Why Is Joan Heller Brown Influential?

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According to Wikipedia, Joan Heller Brown is an American pharmacologist. She is Distinguished Professor and Chair of the Department of Pharmacology at UC San Diego School of Medicine. She is known for fundamental contributions to the understanding of G-protein coupled receptors — molecules that span cell membranes, where they transmit messages between cells and their environments — and how GPCRs regulate cell growth and survival, in healthy and various disease states. Many therapeutic drugs work by influencing GPCRs, thus Heller Brown's discoveries have been crucial to their development.

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Joan Heller Brown's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family* (1998) (920)
Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy. (1990) (628)
Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. (1998) (561)
Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels. (2006) (499)
The &dgr;C Isoform of CaMKII Is Activated in Cardiac Hypertrophy and Induces Dilated Cardiomyopathy and Heart Failure (2003) (479)
Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling. (2006) (468)
Transgenic CaMKII&dgr;C Overexpression Uniquely Alters Cardiac Myocyte Ca2+ Handling: Reduced SR Ca2+ Load and Activated SR Ca2+ Release (2003) (444)
Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II. (2003) (428)
Cardiotrophin 1 (CT-1) Inhibition of Cardiac Myocyte Apoptosis via a Mitogen-activated Protein Kinase-dependent Pathway (1997) (415)
CaMKII in myocardial hypertrophy and heart failure. (2011) (410)
The role of Rho in G protein-coupled receptor signal transduction. (2000) (366)
Cardiac Hypertrophy Induced by Mitogen-activated Protein Kinase Kinase 7, a Specific Activator for c-Jun NH2-terminal Kinase in Ventricular Muscle Cells* (1998) (359)
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. (2009) (349)
Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice. (2010) (337)
The Rac and Rho Hall of Fame: A Decade of Hypertrophic Signaling Hits (2006) (333)
Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II (2008) (322)
Characterization of lpa2 (Edg4) and lpa1/lpa2 (Edg2/Edg4) Lysophosphatidic Acid Receptor Knockout Mice: Signaling Deficits without Obvious Phenotypic Abnormality Attributable to lpa2 (2002) (321)
Atropine, scopolamine and related antimuscarinic drugs (1990) (319)
Inhibition of lipoprotein binding to cell surface receptors of fibroblasts following selective modification of arginyl residues in arginine-rich and B apoproteins. (1977) (309)
The alpha 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy. (1993) (305)
MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. (2010) (293)
Selective Loss of Sphingosine 1-Phosphate Signaling with No Obvious Phenotypic Abnormality in Mice Lacking Its G Protein-coupled Receptor, LPB3/EDG-3* (2001) (286)
Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration. (1999) (284)
Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure. (2004) (283)
Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytes. (1994) (280)
Stimulation by dopamine of adenylate cyclase in retinal homogenates and of adenosine-3':5'-cyclic monophosphate formation in intact retina. (1972) (279)
Alpha 1-adrenergic and muscarinic cholinergic stimulation of phosphoinositide hydrolysis in adult rat cardiomyocytes. (1985) (272)
The Cardiac-specific Nuclear δB Isoform of Ca2+/Calmodulin-dependent Protein Kinase II Induces Hypertrophy and Dilated Cardiomyopathy Associated with Increased Protein Phosphatase 2A Activity* (2002) (264)
Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs). (2012) (259)
Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure. (1999) (257)
Marked Perinatal Lethality and Cellular Signaling Deficits in Mice Null for the Two Sphingosine 1-Phosphate (S1P) Receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3* (2002) (257)
Mechanisms of action of corticotropin-releasing factor and other regulators of corticotropin release in rat pituitary cells. (1983) (255)
Rho as a mediator of G protein-coupled receptor signaling. (1999) (252)
The MEKK-JNK Pathway Is Stimulated by α1-Adrenergic Receptor and Ras Activation and Is Associated with in Vitroand in Vivo Cardiac Hypertrophy* (1997) (249)
An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. (2008) (234)
Phorbol ester inhibits phosphoinositide hydrolysis and calcium mobilization in cultured astrocytoma cells. (1985) (227)
Inhibition of Cardiac Myocyte Apoptosis Improves Cardiac Function and Abolishes Mortality in the Peripartum Cardiomyopathy of G&agr;q Transgenic Mice (2003) (226)
The Nuclear δB Isoform of Ca2+/Calmodulin-dependent Protein Kinase II Regulates Atrial Natriuretic Factor Gene Expression in Ventricular Myocytes* (1997) (226)
Beta-adrenergic receptor signaling in the heart: role of CaMKII. (2010) (219)
Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization. (1985) (218)
Sphingosine-1-phosphate receptor signalling in the heart. (2008) (216)
CaMKIIδ Isoforms Differentially Affect Calcium Handling but Similarly Regulate HDAC/MEF2 Transcriptional Responses* (2007) (211)
Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. (2007) (211)
G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival (2004) (210)
Rho Is Required for Gαq and α1-Adrenergic Receptor Signaling in Cardiomyocytes (1996) (208)
APJ ACTS AS A DUAL RECEPTOR IN CARDIAC HYPERTROPHY (2012) (207)
Increased Sarcoplasmic Reticulum Calcium Leak but Unaltered Contractility by Acute CaMKII Overexpression in Isolated Rabbit Cardiac Myocytes (2006) (204)
Agonists differentiate muscarinic receptors that inhibit cyclic AMP formation from those that stimulate phosphoinositide metabolism. (1984) (201)
G protein‐coupled receptors and signaling pathways regulating growth responses 1 (1996) (200)
Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation. (1994) (192)
Dissociation of p44 and p42 Mitogen-activated Protein Kinase Activation from Receptor-induced Hypertrophy in Neonatal Rat Ventricular Myocytes (*) (1996) (192)
Initiation and Transduction of Stretch-induced RhoA and Rac1 Activation through Caveolae (2003) (190)
Gq signaling in cardiac adaptation and maladaptation. (1999) (188)
Calcium/Calmodulin-Dependent Protein Kinase II Contributes to Cardiac Arrhythmogenesis in Heart Failure (2009) (173)
Penetration of linezolid into bone, fat, muscle and haematoma of patients undergoing routine hip replacement. (2002) (173)
G Alpha-q/11 Protein Plays a Key Role in Insulin-Induced Glucose Transport in 3T3-L1 Adipocytes (1999) (160)
Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes. (1992) (156)
Guanosine 5'-O-(thiotriphosphate)-dependent inositol trisphosphate formation in membranes is inhibited by phorbol ester and protein kinase C. (1987) (150)
Novel Allosteric Sites on Ras for Lead Generation (2011) (148)
Gα12 Stimulates c-Jun NH2-terminal Kinase through the Small G Proteins Ras and Rac* (1996) (148)
c-Jun N-Terminal Kinase Activation Mediates Downregulation of Connexin43 in Cardiomyocytes (2002) (146)
Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca2+/Calmodulin-Dependent Protein Kinase II &dgr; Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling (2018) (145)
Increased Expression and Activity of RhoA Are Associated With Increased DNA Synthesis and Reduced p27Kip1 Expression in the Vasculature of Hypertensive Rats (2001) (143)
Hormonally specific expression of cardiac protein kinase activity. (1979) (141)
CaMKII Negatively Regulates Calcineurin–NFAT Signaling in Cardiac Myocytes (2009) (139)
Serum hepatic enzyme and bilirubin elevations during parenteral nutrition. (1977) (136)
RhoA/Rho Kinase Up-regulate Bax to Activate a Mitochondrial Death Pathway and Induce Cardiomyocyte Apoptosis* (2007) (135)
Epac2 Mediates Cardiac &bgr;1-Adrenergic–Dependent Sarcoplasmic Reticulum Ca2+ Leak and Arrhythmia (2013) (135)
Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice. (2018) (134)
Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death. (2008) (133)
A Critical Function for Ser-282 in Cardiac Myosin Binding Protein-C Phosphorylation and Cardiac Function (2011) (127)
Verapamil competitively inhibits alpha 1-adrenergic and muscarinic but not beta-adrenergic receptors in rat myocardium. (1982) (124)
G-proteins in growth and apoptosis: lessons from the heart (2001) (121)
The alpha-adrenergic stimulation of atrial natriuretic factor expression in cardiac myocytes requires calcium influx, protein kinase C, and calmodulin-regulated pathways. (1991) (119)
Phospholamban Ablation Rescues Sarcoplasmic Reticulum Ca2+ Handling but Exacerbates Cardiac Dysfunction in CaMKII&dgr;C Transgenic Mice (2010) (117)
Muscarinic receptor activation of phosphatidylcholine hydrolysis. Relationship to phosphoinositide hydrolysis and diacylglycerol metabolism. (1989) (116)
Role of phospholipase Cε in physiological phosphoinositide signaling networks. (2012) (116)
A direct role for protein kinase C and the transcription factor Jun/AP-1 in the regulation of the Alzheimer's beta-amyloid precursor protein gene. (1994) (115)
The Low Molecular Weight GTPase Rho Regulates Myofibril Formation and Organization in Neonatal Rat Ventricular Myocytes (1998) (115)
Cardiomyocyte Apoptosis Induced by G&agr;q Signaling Is Mediated by Permeability Transition Pore Formation and Activation of the Mitochondrial Death Pathway (2000) (114)
A Rho Exchange Factor Mediates Thrombin and Gα12-induced Cytoskeletal Responses* (1999) (112)
Rho is required for Galphaq and alpha1-adrenergic receptor signaling in cardiomyocytes. Dissociation of Ras and Rho pathways. (1996) (108)
Focal Adhesion Kinase as a RhoA-activable Signaling Scaffold Mediating Akt Activation and Cardiomyocyte Protection* (2008) (105)
Akt mediated mitochondrial protection in the heart: metabolic and survival pathways to the rescue (2009) (105)
PHLPP-1 Negatively Regulates Akt Activity and Survival in the Heart (2010) (103)
Requirement for Ca 2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice (Journal of Clinical Investigation (2009) 119, 5, (1230-1240) doi: 10.1172/JCI38022) (2012) (102)
c-fos and c-jun are induced by muscarinic receptor activation of protein kinase C but are differentially regulated by intracellular calcium. (1991) (102)
Ca2+/Calmodulin-Dependent Protein Kinase II &dgr; Mediates Myocardial Ischemia/Reperfusion Injury Through Nuclear Factor-&kgr;B (2013) (101)
G12 Requirement for Thrombin-stimulated Gene Expression and DNA Synthesis in 1321N1 Astrocytoma Cells (*) (1995) (99)
Physical and Functional Interactions of Gαq with Rho and Its Exchange Factors* (2001) (94)
Pim-1 Kinase Protects Mitochondrial Integrity in Cardiomyocytes (2010) (94)
Rapid protein kinase C-dependent activation of phospholipase D leads to delayed 1,2-diglyceride accumulation. (1990) (92)
Requirement for Rho-mediated Myosin Light Chain Phosphorylation in Thrombin-stimulated Cell Rounding and Its Dissociation from Mitogenesis* (1998) (91)
Relationships between phosphoinositide and calcium responses to muscarinic agonists in astrocytoma cells. (1984) (91)
Oxidative stress and erythrocyte membrane fluidity in patients undergoing regular dialysis. (1995) (89)
G Protein–Coupled Receptor and RhoA-Stimulated Transcriptional Responses: Links to Inflammation, Differentiation, and Cell Proliferation (2015) (89)
Biological studies on an adrenocorticolytic agent and the isolation of the active components. (1958) (88)
The putative M1 muscarinic receptor does not regulate phosphoinositide hydrolysis. Studies with pirenzepine and McN-A343 in chick heart and astrocytoma cells. (1985) (87)
Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis. (2011) (87)
RhoA protects the mouse heart against ischemia/reperfusion injury. (2011) (86)
Role of Ca 2 + / calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure (2004) (85)
Akt regulates L-type Ca2+ channel activity by modulating Cavα1 protein stability (2009) (85)
Muscarinic stimulation of phosphatidylinositol metabolism in atria. (1983) (84)
CaMKIIδ-mediated inflammatory gene expression and inflammasome activation in cardiomyocytes initiate inflammation and induce fibrosis. (2018) (82)
Guanine nucleotide regulation of agonist binding to muscarinic cholinergic receptors. Relation to efficacy of agonists for stimulation of phosphoinositide breakdown and Ca2+ mobilization. (1985) (80)
Regulation of c-fos and c-jun protooncogene expression by the Ca(2+)-ATPase inhibitor thapsigargin. (1991) (80)
Location Matters: Clarifying the Concept of Nuclear and Cytosolic CaMKII Subtypes (2011) (80)
Presynaptic modulation of acetylcholine release from cardiac parasympathetic neurons. (1985) (79)
S1P1 Receptor Localization Confers Selectivity for Gi-mediated cAMP and Contractile Responses* (2008) (78)
Rho Kinase Polymorphism Influences Blood Pressure and Systemic Vascular Resistance in Human Twins: Role of Heredity (2006) (78)
Dissociation of protein kinase C redistribution from the phosphorylation of its substrates. (1991) (78)
Heterogeneity of binding sites on cardiac muscarinic receptors induced by the neuromuscular blocking agents gallamine and pancuronium. (1983) (77)
Lysophospholipid receptor activation of RhoA and lipid signaling pathways. (2013) (77)
RHO SIGNALING in vascular diseases. (2004) (77)
Lysophosphatidic acid induces hypertrophy of neonatal cardiac myocytes via activation of Gi and Rho. (2004) (76)
Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells. (1996) (76)
Phospholipase Cɛ links G protein-coupled receptor activation to inflammatory astrocytic responses (2013) (74)
Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes (2017) (73)
Akt-mediated Cardiomyocyte Survival Pathways Are Compromised by Gαq-induced Phosphoinositide 4,5-Bisphosphate Depletion* (2003) (72)
Akt Increases Sarcoplasmic Reticulum Ca2+ Cycling by Direct Phosphorylation of Phospholamban at Thr17* (2009) (72)
Phospholipase Cε is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation (2007) (71)
Myocardin-Related Transcription Factor A and Yes-Associated Protein Exert Dual Control in G Protein-Coupled Receptor- and RhoA-Mediated Transcriptional Regulation and Cell Proliferation (2015) (70)
Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: differential effects of muscarinic and thrombin receptor activation (1992) (70)
Tumor Necrosis Factor-α-stimulated Cell Proliferation Is Mediated through Sphingosine Kinase-dependent Akt Activation and Cyclin D Expression* (2007) (70)
CaMKIIdelta subtypes: localization and function (2014) (68)
CaMKIIδ mediates β-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic β-adrenergic stimulation. (2015) (68)
Increases in intracellular Ca2+ regulate the binding of [3H]phorbol 12,13-dibutyrate to intact 1321N1 astrocytoma cells. (1989) (67)
Acetylcholine release from rat atria can be regulated through an alpha 1-adrenergic receptor. (1985) (66)
Studies on the acute inflammatory response. I. Involvement of the central nervous system in certain models of inflammation. (1968) (65)
Agonist-induced desensitization of muscarinic receptor-mediated calcium efflux without concomitant desensitization of phosphoinositide hydrolysis. (1985) (65)
Phosphatidylinositol 3,4,5-Triphosphate-Dependent Rac Exchanger 1 (P-Rex-1), a Guanine Nucleotide Exchange Factor for Rac, Mediates Angiogenic Responses to Stromal Cell-Derived Factor-1/Chemokine Stromal Cell Derived Factor-1 (SDF-1/CXCL-12) Linked to Rac Activation, Endothelial Cell Migration, and (2010) (64)
Cardiomyocyte calcium and calcium/calmodulin-dependent protein kinase II: friends or foes? (2004) (64)
Akt regulates L-type Ca2+ channel activity by modulating Cavα1 protein stability (2009) (64)
A requirement for Ras protein function in thrombin-stimulated mitogenesis in astrocytoma cells. (1993) (62)
The Muscarinic Receptors (1989) (62)
CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury. (2014) (61)
Tyrosine kinase and c-Jun NH2-terminal kinase mediate hypertrophic responses to prostaglandin F2alpha in cultured neonatal rat ventricular myocytes. (1998) (61)
Pertussis Toxin‐Insensitive Phosphoinositide Hydrolysis, Membrane Depolarization, and Positive Inotropic Effect of Carbachol in Chick Atria (1987) (61)
Ca2+ Dysregulation Induces Mitochondrial Depolarization and Apoptosis (2005) (61)
PLCε, PKD1, and SSH1L Transduce RhoA Signaling to Protect Mitochondria from Oxidative Stress in the Heart (2013) (56)
Cardiac hypertrophy and heart failure development through Gq and CaM kinase II signaling. (2010) (56)
signaling in cardiac myocyte excitation- transcription coupling (2006) (55)
Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via O-linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes (2020) (55)
Mitochondrial reprogramming induced by CaMKIIδ mediates hypertrophy decompensation. (2015) (54)
Differences in muscarinic receptor reserve for inhibition of adenylate cyclase and stimulation of phosphoinositide hydrolysis in chick heart cells. (1986) (53)
Cyclic AMP in retina and caudate nucleus: influence of dopamine and other agents. (1975) (52)
Endothelin ETA receptor regulates signaling and ANF gene expression via multiple G protein-linked pathways. (1997) (52)
Upregulation of GLUT1 expression is necessary for hypertrophy and survival of neonatal rat cardiomyocytes. (2003) (52)
Inhibition of Heat-Induced Denaturation of Serum Proteins by Mixtures of Nonsteroidal Anti-Inflammatory Agents and Amino Acids (1968) (50)
CaMKIIδ subtypes differentially regulate infarct formation following ex vivo myocardial ischemia/reperfusion through NF-κB and TNF-α. (2017) (49)
Yes-associated protein (YAP) mediates adaptive cardiac hypertrophy in response to pressure overload (2019) (49)
Molecular species specificity of phospholipid breakdown in microsomal membranes of senescing carnation flowers. (1987) (48)
Human immunodeficiency virus type 1 (HIV-1) inhibition, DNA-binding, RNA-binding, and ribosome inactivation activities in the N-terminal segments of the plant anti-HIV protein GAP31. (1994) (48)
Elevation of cytoplasmic calcium concentration stimulates hydrolysis of phosphatidylinositol bisphosphate in chick heart cells: effect of sodium channel activators. (1988) (48)
Transgenic CaMKII C Overexpression Uniquely Alters Cardiac Myocyte Ca (2003) (48)
The Rho effector, PKN, regulates ANF gene transcription in cardiomyocytes through a serum response element. (2000) (47)
The Ras-related Protein, Rap1A, Mediates Thrombin-stimulated, Integrin-dependent Glioblastoma Cell Proliferation and Tumor Growth* (2014) (47)
alpha 1- and beta 2-adrenergic receptor expression in the Madin-Darby canine kidney epithelial cell line (1983) (47)
Oxidative stress in cyclosporin and azathioprine treated renal transplant patients. (1997) (46)
Guanine Nucleotide‐Dependent Inositol Trisphosphate Formation in Chick Heart Cells (1988) (46)
Intracellular signalling mechanism responsible for modulation of sarcolemmal ATP‐sensitive potassium channels by nitric oxide in ventricular cardiomyocytes (2014) (46)
Revisited and Revised: Is RhoA Always a Villain in Cardiac Pathophysiology? (2010) (46)
Desensitization and recovery of muscarinic and histaminergic Ca2+ mobilization in 1321N1 astrocytoma cells. (1988) (45)
Thrombin receptor and RhoA mediate cell proliferation through integrins and cysteine‐rich protein 61 (2008) (44)
Rho‐mediated cytoskeletal rearrangement in response to LPA is functionally antagonized by Rac1 and PIP2 (2004) (42)
YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity (2018) (42)
A high-resolution consensus linkage map of the rat, integrating radiation hybrid and genetic maps. (2001) (42)
Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction (2016) (41)
RhoA regulates Drp1 mediated mitochondrial fission through ROCK to protect cardiomyocytes. (2018) (41)
THE CHEMICAL FRACTIONATION OF AN ADRENOCORTICOLYTIC DRUG123 (1958) (41)
Inflammation in non-ischemic heart disease: initiation by cardiomyocyte CaMKII and NLRP3 inflammasome signaling. (2019) (40)
Nonequilibrium Reactivation of Na+ Current Drives Early Afterdepolarizations in Mouse Ventricle (2014) (40)
PHLPP1 Gene Deletion Protects the Brain from Ischemic Injury (2013) (39)
Analysis of cardiac muscarinic receptors recognized selectively by nonquaternary but not by quaternary ligands. (1986) (38)
beta-Adrenergic receptor stimulated Ncx1 upregulation is mediated via a CaMKII/AP-1 signaling pathway in adult cardiomyocytes. (2010) (38)
RGS16 inhibits signalling through the Gα13–Rho axis (2003) (38)
Parasympathetic effects on in vivo rat heart can be regulated through an alpha 1-adrenergic receptor. (1987) (37)
Gαq expression activates EGFR and induces Akt mediated cardiomyocyte survival: dissociation from Gαq mediated hypertrophy (2006) (37)
Studies on the phospholipase A activity of Crotalus atrox venom. (1966) (37)
Calmodulin and Ca2+/calmodulin kinases in the heart - physiology and pathophysiology. (2007) (37)
Overexpression of CaMKIIδc in RyR2R4496C+/- knock-in mice leads to altered intracellular Ca2+ handling and increased mortality. (2011) (37)
Influence of Acyl Chain Composition on the Degradation of Phosphatidylcholine by Phospholipase D in Carnation Microsomal Membranes (1990) (37)
Inositol Polyphosphate 1-Phosphatase Is a Novel Antihypertrophic Factor* (2002) (36)
Relationships between choline uptake, acetylcholine synthesis and acetylcholine release in isolated rat atria. (1983) (36)
Conversion of skeletal muscle glycogen synthase to multiple glucose 6-phosphate dependent forms by cyclic adenosine monophosphate dependent and independent protein kinases. (1977) (36)
A Novel in vitro Assay for Anti-Inflammatory Agents Based on Stabilization of Erythrocytes (1967) (35)
Stimulation of testosterone production in the cynomolgus monkey in vivo by deglycosylated and desialylated human choriogonadotropin. (1989) (35)
The G12 coupled thrombin receptor stimulates mitogenesis through the Shc SH2 domain (1997) (35)
Muscarinic-dopaminergic synergism on retinal cyclic AMP formation (1981) (34)
ON THE MECHANISM OF RESORCIN-FUCHSIN STAINING (1961) (34)
G protein-coupled receptors go extracellular: RhoA integrates the integrins. (2008) (33)
The calculation of equilibrium mole fractions of polar‐polar, nonpolar‐polar, and ion dimers (1974) (32)
The promise of CaMKII inhibition for heart disease: preventing heart failure and arrhythmias (2013) (32)
Sphingosine 1-phosphate S 1 P 2 and S 1 P 3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury (2007) (32)
Thrombin and trypsin act at the same site to stimulate phosphoinositide hydrolysis and calcium mobilization. (1989) (32)
A new non-canonical pathway of Gα(q) protein regulating mitochondrial dynamics and bioenergetics. (2014) (32)
Receptor-mediated inositol phosphate formation in relation to calcium mobilization: a comparison of two cell lines. (1987) (31)
CaMKIIδC slows [Ca]i decline in cardiac myocytes by promoting Ca sparks. (2012) (30)
Physical and functional interactions of Galphaq with Rho and its exchange factors. (2001) (30)
Protein kinase Cε-dependent activation of proline-rich tyrosine kinase 2 in neonatal rat ventricular myocytes (2003) (30)
Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection. (2014) (30)
Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection. (2017) (29)
Phosphoinositide-generated second messengers in cardiac signal transduction. (1992) (29)
Stabilization of hepatic lysosomes of rats by vitamin E and selenium in vivo as indicated by thermal labilization of isolated lysosomes. (1972) (29)
Ethylene Binding to Senescing Carnation Petals (1986) (29)
localization and function. (2014) (29)
Synthesis, Storage and Release of Acetylcholine (1999) (28)
Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure. (2017) (28)
M1Muscarinic Receptors Heterologously Expressed in Cardiac Myocytes Mediate Ras-dependent Changes in Gene Expression (*) (1995) (28)
Interaction of Lysosomes and Anti-inflammatory Drugs (1969) (27)
Active site mapping of Loxosceles phospholipases D: biochemical and biological features (2016) (27)
Extra-thyroidal iodide metabolism in the rat. (1956) (27)
CHAPTER FOUR – Physiological Mechanisms of Plant Senescence (1991) (27)
Studies on the acute inflammatory response. II. Influence of antihistaminics and catecholamines on formaldehyde-induced edema. (1968) (27)
Decline in cellular function of aged mouse c‐kit+ cardiac progenitor cells (2017) (27)
Epac 2 Mediates Cardiac β 1-Adrenergic – Dependent Sarcoplasmic Reticulum Ca 2 + Leak and Arrhythmia (2013) (27)
Does phosphoinositide hydrolysis mediate ‘inhibitory’ as well as ‘excitatory’ muscarinic responses? (1984) (26)
SR-targeted CaMKII inhibition improves SR Ca²+ handling, but accelerates cardiac remodeling in mice overexpressing CaMKIIδC. (2011) (26)
Rapid heterologous desensitization of muscarinic and thrombin receptor-mediated phospholipase D activation. (1994) (26)
Further characterization of the presynaptic alpha-1 receptor modulating [3H]ACh release from rat atria. (1986) (26)
RGS16 inhibits signalling through the G alpha 13-Rho axis. (2003) (25)
The involvement of activated oxygen in membrane deterioration during senescence (1987) (25)
Glycopyrrolate as a premedicant: comparison with atropine. (1979) (25)
SiglecF(HI) Marks Late‐Stage Neutrophils of the Infarcted Heart: A Single‐Cell Transcriptomic Analysis of Neutrophil Diversification (2021) (25)
Differences and Similarities in Muscarinic Receptors of Rat Heart and Retina: Effects of Agonists, Guanine Nucleotides, and N‐Ethylmaleimide (1984) (24)
Pathways and roadblocks in muscarinic receptor-mediated growth regulation. (1997) (24)
Stimulation of phosphoinositide hydrolysis and inhibition of cyclic AMP formation by muscarinic agonists in developing chick heart. (1985) (24)
UTP but not ATP causes hypertrophic growth in neonatal rat cardiomyocytes. (2003) (23)
C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation (2017) (22)
The temperature dependence of the NO–O chemiluminous recombination. The RMC mechanism (1975) (22)
Crossing signals: relationships between β-adrenergic stimulation and CaMKII activation. (2011) (21)
In vivo selective expression of thyroid hormone receptor α1 in endothelial cells attenuates myocardial injury in experimental myocardial infarction in mice. (2014) (21)
Activation and blockade of cardiac muscarinic receptors by endogenous acetylcholine and cholinesterase inhibitors. (1982) (21)
Formation of sorbitol 6-phosphate by bovine and human lens aldose reductase, sorbitol dehydrogenase and sorbitol kinase. (1982) (21)
PLCε mediated sustained signaling pathways. (2015) (21)
Cell Fractionation of Anterior Pituitary Glands from Beef and Pig (1959) (20)
CaMKIIδC Drives Early Adaptive Ca2+ Change and Late Eccentric Cardiac Hypertrophy (2020) (20)
Verapamil Competitively Inhibits α1-Adrenergic and Muscarinic but Not β‐Adrenergic Receptors in Rat Myocardium (1982) (20)
Galphaq expression activates EGFR and induces Akt mediated cardiomyocyte survival: dissociation from Galphaq mediated hypertrophy. (2006) (19)
Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs. (2016) (19)
Some Reactions and Properties of the Phosphorus Sulfides (1949) (19)
A secretory pathway kinase regulates sarcoplasmic reticulum Ca2+ homeostasis and protects against heart failure (2018) (19)
metabolic flexibility, and propensity for heart failure in mice (2010) (19)
Influence of the Drug DDD on Adrenal Cortical Function in Adult Rats.∗ † (1953) (19)
Depolarization-induced inhibition of cyclic AMP accumulation: cholinergic-adrenergic antagonism in murine atria. (1979) (19)
Drug interactions with dopamin-stimulated adenylate cyclasses of caudate nucleus and retina: direct agonist effect of a piribedil metabolite. (1975) (18)
Receptor reserve in the calcium-dependent cyclic AMP response of astrocytoma cells to muscarinic receptor stimulation: demonstration by agonist-induced desensitization, receptor inactivation, and phorbol ester treatment. (1986) (18)
Reductions in the Cardiac Transient Outward K+ Current Ito Caused by Chronic β-Adrenergic Receptor Stimulation Are Partly Rescued by Inhibition of Nuclear Factor κB* (2016) (17)
Acyl chain and head group regulation of phospholipid catabolism in senescing carnation flowers. (1991) (17)
Cardioprotective stimuli mediate phosphoinositide 3-kinase and phosphoinositide dependent kinase 1 nuclear accumulation in cardiomyocytes. (2009) (17)
Hyperlysinuria with hyperammonemia. A new metabolic disorder. (1972) (17)
Identification of Potential Small Molecule Binding Pockets on Rho Family GTPases (2012) (16)
Cholinergic inhibition of catecholamine-stimulable cyclic AMP accumulation in murine atria. (1979) (16)
Stability of solutions of essential amino acids. (1973) (15)
Muscarinic regulation of phosphatidylinositol turnover and cyclic nucleotide metabolism in the heart. (1984) (15)
Pertussis toxin-sensitive and -insensitive thrombin stimulation of Shc phosphorylation and mitogenesis are mediated through distinct pathways. (1999) (14)
Thrombin Promotes Sustained Signaling and Inflammatory Gene Expression through the CDC25 and Ras-associating Domains of Phospholipase Cϵ* (2015) (14)
Studies on the acute inflammatory response. 3. Glucocorticoids and vitamin E (in vivo) attenuate thermal labilization of isolated hepatic lysosomes. (1971) (14)
Chemiluminescence of trimethyl aluminum in active oxygen and nitrogen (1976) (13)
AMINO TERMINAL AMINO ACIDS OF HOG PANCREATIC AMYLASE AND THEIR RELATIONSHIP TO ITS ENZYMIC ACTIVITY. (1965) (13)
Exercise training reverses myocardial dysfunction induced by CaMKIIδC overexpression by restoring Ca2+ homeostasis. (2016) (13)
Some Effects of Depletion and Repletion in Proteins on Body Fluids in Adult Dogs.∗ (1946) (12)
Membrane phospholipid catabolism primes the production of activated oxygen in senescing tissues (1991) (12)
Specific [3H]-N-methyl scopolamine binding without cholinergic function in cultured adult skin fibroblasts. (1986) (11)
Calmodulin and Ca 2+ /calmodulin kinases in the heart — Physiology and pathophysiology (2007) (11)
In vitro metabolism of substituted steroids by rat liver. (1958) (11)
Protein kinase C epsilon-dependent activation of proline-rich tyrosine kinase 2 in neonatal rat ventricular myocytes. (2003) (11)
The influence of cortisone on the action of an adrenocorticolytic drug. (1957) (10)
Further Studies on the Erythrocyte Anti-Inflammatory Assay (1968) (10)
Prophylactic effects of cyclophosphamide in adjuvant-induced arthritis. (1970) (9)
Distribution of Hydrolases among Anterior Pituitary Cell Fractions (Anterior Pituitary Hydrolases) (1958) (9)
Effect of duration of administration of cyclophosphamide and steroidal anti-inflammatory drugs on the severity of polyarthritis. (1971) (8)
Oral effectiveness of beta adrenergic antagonists in preventing epinephrine-induced metabolic responses. (1968) (8)
A 22 kDa ras‐related G‐protein is the substrate for an ADP‐ribosyltransferase from Clostridium botulinum (1988) (8)
Spatiotemporal restriction of endothelial cell calcium signaling is required during leukocyte transmigration (2020) (8)
GTP-binding protein-stimulated phospholipase C and phospholipase D activities in ras-transformed NIH 3T3 fibroblasts. (1990) (8)
The chemical fractionation of an adrenocorticolytic drug. (1958) (8)
Binding of [1-13C]galactose-labeled N-acetyllactosamine to Erythrina cristagalli agglutinin as studied by 13C-NMR. (1985) (8)
Effect of pH, temperature, antivenin and functional group inhibitors on the toxicity and enzymatic activities of Crotalus atrox venom. (1966) (8)
Separation of hormonal activities in the anterior pituitary by ultracentrifugation. (1956) (8)
Studies on the intracellular localization of anterior pituitary hormones by means of differential centrifugation. (1960) (8)
Muscarinic Cholinergic Receptor Regulation of Inositol Phospholipid Metabolism and Calcium Mobilization (1989) (8)
Effect of Sotalol (M.T 1999) and Propranolol on Insulin-Induced Hypoglycemia in the Rat (1968) (7)
Stimulation of phosphoinositide hydrolysis by thrombin in embryonic chick heart cells (1986) (7)
Studies on ultracentrifuge fractions of anterior pituitary with special reference to adrencorticotrophic hormone. (1960) (7)
The influence of DDD on the course of alloxan diabetes in the adult rat. (1953) (7)
Organ culture of rat superior cervical ganglia. (1977) (6)
ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ (2021) (6)
Dephosphorylation and activation of exogenous glycogen synthase by adipose-tissue phosphatase. (1980) (6)
Multiple pathways for signal transduction through the muscarinic cholinergic receptor. (1990) (6)
Drp1 and Mitochondrial Autophagy Lend a Helping Hand in Adaptation to Pressure Overload. (2016) (6)
Lipid signalling in cardiovascular pathophysiology. (2008) (6)
RhoA signaling increases mitophagy and protects cardiomyocytes against ischemia by stabilizing PINK1 protein and recruiting Parkin to mitochondria (2022) (6)
Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice (2022) (5)
Phospholipid metabolism in membranes of senescing bean cotyledons (1994) (5)
In vitro metabolism of hydrocortisone in tissues of the adult rat. (1957) (5)
Relative degree of tolerance to morphine sulfate and methadone hydrochloride in the rat and the interaction of dexamethasone. (1972) (5)
Integration and coordination of metabolic processes: A systems approach to endocrinology (1978) (5)
Histamine-induced biphasic activation of RhoA allows for persistent RhoA signaling (2020) (4)
Pulsatile equibiaxial stretch inhibits thrombin-induced RhoA and NF-kappaB activation. (2008) (4)
NONSPECIFICITY OF THE MECHANISM THAT ELICITS MYOCARDIAL NECROSES IN HUMORALLY CONDITIONED RATS (1958) (4)
Co‐occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence (2021) (4)
Influence of Urine Volume on Output of Corticoids by Normal Human Subjects.∗ (1958) (4)
MRTF‐A and YAP exert dual control in GPCR and RhoA‐mediated transcriptional regulation and cell proliferation (2016) (3)
The contribution of the cardiomyocyte to tissue inflammation in cardiomyopathies (2020) (3)
CaMKII confirms its promise in ischaemic heart disease (2014) (3)
Jojobutter-51TM ― A primary dermal irritation study in rabbits (1984) (3)
Phosphoproteomic Identification of CaMKII- and Heart Failure-Dependent Phosphorylation Sites on the Native Cardiac Nav1.5 Channel Protein (2014) (3)
Regulation of phosphoinositide hydrolysis by GTP-binding proteins, phorbol esters and botulinum toxin type D. (1988) (3)
Inhibition of Antigen-Antibody Reactions in Vitro by Nonsteroidal Anti-Inflammatory Agents (1968) (3)
The First 50 Years of Molecular Pharmacology (2015) (3)
Bitopic S1P 3 Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P 3 Regulation of Mouse Cardiac Conduction (2015) (3)
Inhibition of Constriction-Induced Reactive Hyperemic Edema (1972) (2)
MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice (Journal of Clinical Investigation (2010) 120, 8, (2805-2816) DOI: 10.1172/JCI43008) (2010) (2)
Calcium-dependent blockade of cardiac cyclic AMP accumulation by batrachotoxin and veratridine. (1981) (2)
Erratum: An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice (Journal of Clinical Investigation (2008) 118, 12, (3870-3880) doi:10.1172/JCI34472) (2012) (2)
Muscarinic receptor regulation of protein kinase C distribution and phosphatidylcholine hydrolysis. (1990) (2)
EFFECT OF ENZYMATIC FUNCTIONAL GROUP INHIBITORS ON PROTEOLYTIC ENZYMES OF CROTALUS ATROX VENOM. REP NO. 622. (1965) (2)
CaMKIIδ splice variants exert differential effects on heart failure development and myocardial ischemia/reperfusion injury (652.14) (2014) (2)
βAr-Stimulation Causes EADs but not DADs in Pre-Failure CAMKIIδC Transgenic Myocytes (2012) (2)
Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes (2017) (2)
Functional Aspects of Cholinergic Neurotransmission (1999) (1)
CCL2‐ Dependent Macrophage Recruitment by Glioblastoma Stem Cells: The Role of Gα12 and YAP Signaling (2021) (1)
Acetylcholinesterase and the Termination of Acetylcholine Action (1999) (1)
Epac 2 Mediates Cardiac 1-Adrenergic Dependent SR Ca 2 + Leak and Arrhythmia Running title : (2013) (1)
Chlorine, its manufacture, properties and uses ACS monograph 154: Edited by James S. Sconce Reinhold: New York, 1963. (x+901 pp.; 614in. by 914in.), 200s or $25.00 (1963) (1)
Abstract 14162: NLRP3 Inflammasome Activation Initiated Through Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKIIδ) Signaling in Cardiomyocytes is Essential for Pressure Overload-Induced Adverse Cardiac Remodeling (2018) (1)
Title CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia / reperfusion injury (2014) (1)
CaMKII delta subtypes differentially regulate infarct formation following ex vivo myocardial ischemia/reperfusion through NF-kappa B and TNF-alpha (2017) (1)
Anti-inflammatory activity of sodium fluorde. (1972) (1)
INFLUENCE OF ERGOT DERIVATIVES ON THE DIFFERENT TYPES OF DOPAMINE RECEPTORS AND ON OTHER AMINE RECEPTORS IN PRIMATE BRAIN (1979) (1)
Abstract 18574: Mitochondrial Reprogramming By Camkiiδ Underlies Gq-induced Cardiomyopathy (2012) (1)
Differential Effects of Carbachol and Oxotremorine on Muscarinic Receptors, Cyclic Amp Formation, and Phosphoinositide Turnover in Chick Heart Cells (1986) (1)
G Protein-Coupled Receptors Go Extracellular: (2009) (1)
Acetylcholine and Muscarinic Receptors (2012) (1)
NLRP3 Inflammasome Products IL‐1beta and IL‐18 Have A Direct Effect on Cardiomyocytes (2020) (1)
Abstract 18536: Camkii-{delta} Splice Variants Exert Differential Effects on Heart Failure Development and Myocardial Ischemia / Reperfusion Injury (2012) (1)
ai-Adrenergic and Muscarinic Cholinergic Stimulation of Fhosphoinositide Hydrolysis in Adult Rat Cardiomyocytes (2005) (1)
RhoA regulates mitochondrial quality control through mitophagy and mitochondrial fission (2018) (0)
Thrombin stimulated glioblastoma cell adhesion is mediated by Rap1 and integrin activation (2012) (0)
Abstract 4101: Thrombin stimulates glioblastoma cell proliferation, adhesion and in vivo tumor growth through Rap1 activation. (2013) (0)
0251: Endocytosis pathway of Kv1.5 channels in atrial cardiomyocytes (2014) (0)
RhoA signaling in cardiomyocyte survival and apoptosis (2007) (0)
Cyclic Nucleotide Accumulation and Hormonal Modulation of Cardiac Metabolism and Contraction (1979) (0)
RhoA mediated transcriptional pathways in tumor cell growth (2018) (0)
Thrombin mediated regulation of CCN1 regulates cell proliferation in an integrin dependent manner (2008) (0)
BRIEF COMMUNICATIONS Acetylcholine Release from Rat Atria Can Be Regulated through an arAdrenergic Receptor (2005) (0)
Abstract 15993: Ablation of Phosphatase-1-Inhibitor-1 is Detrimental in CaMKII Overexpression Despite Reduction of SR Ca2+ Leak (2011) (0)
Abstract 228: CaMKII as a Link Between Inflammation and Fibrosis Induced by Chronic Isoproterenol and Angiotensin II Treatment (2015) (0)
Abstract 424: Activation of the S1P3 Receptors is Responsible for S1P-mediated RhoA Activation and Cardioprotection (2015) (0)
Abstract 5324: Endurance Training Abolish Arrhythmogenic Calcium Leak In Cardiomyocytes From Mice With Transgenic Over-expression Of Camkii{delta}C (2008) (0)
Calcium/Calmodulin‐dependent Protein Kinase II (CaMKII) Signaling in Cardiomyocytes Initiates Inflammatory Responses Required for Adverse Cardiac Remodeling in Response to Pressure Overload. (2018) (0)
Cardiomyocyte‐generated Monocyte Chemoattractant Protein 1 Contributes to Cardiac Inflammation During Adverse Remodeling in Pressure Overload (2020) (0)
Advances in Biological Regulation (0)
Effect of chronic JUUL aerosol inhalation on inflammatory states of the brain, lung, heart and colon in mice (2021) (0)
Abstract P290: RhoA Protects Against Myocardial Ischemia/Reperfusion Injury (2011) (0)
0279: Phosphoproteomic identification of CAMKII- and SGK1-dependent phosphorylation sites on the native cardiac NAV1.5 channel protein in heart failure (2014) (0)
Akt regulates L-type Ca 2+ channel activity by modulating Ca v (cid:2) 1 protein stability (2009) (0)
Inducible cardiac‐specific RhoA‐expression protects against ischemia/reperfusion injury in mouse hearts (2010) (0)
Editorial Board (2009) (0)
(cardiac cyclic AMP-dependent protein kinase/hormonal specificity/glycogenolytic cascade/prostaglandin E1/ l-adrenergic stimulation) (2016) (0)
RhoA Regulation of Drp1 and Cardiac Mitochondrial Fission (2016) (0)
Abstract 19576: Identification of a Novel Signaling Pathway for S1P Mediated Cardioprotection (2012) (0)
Chemistry of Acetylcholine (1999) (0)
Role of S1P signaling in TNF‐mediated 1321N1 cell proliferation (2006) (0)
CaM Kinase IIδ Is Required for Catecholamine-Induced Cardiac Fibrosis but Not Hypertrophy (2010) (0)
Constitutive Activation of CaMKII Reduces Cardiac Function and Viability in Feline Ventricular Myocytes (2007) (0)
Gq- and Ras-dependent Pathways Mediate Hypertrophy (2001) (0)
S1P induces CCN1 expression through RhoA/MRTF‐a activation and protects cardiomyocytes against cell death (2012) (0)
Regulation of glioblastoma tumor growth and stem cell properties through Gα12: an upstream player in YAP signaling (2020) (0)
S1P receptor localization confers selectivity for Gi mediated signaling pathways (2008) (0)
Phospholamban Ablation Rescues SR Ca2+ Loading But Not Cardiac Function In CaMKIIλC Transgenic Mice (2006) (0)
Impact of CaMKII Localization on Function (2008) (0)
RECEPTOR-EFFECTOR COUPLING IN CARDIAC MUSCLE (1979) (0)
RhoA Regulates PINK1 Accumulation and Mitophagy through PKD Activation (2017) (0)
Organization of the Cholinergic Nervous System (1999) (0)
Figure 11-1, [Structure of acetylcholine. A: The...]. (1999) (0)
Abstract P185: Cardiac Characterization of Phlpp1 Knockout Mice: A Novel Phosphatase to Terminate Akt Signaling (2011) (0)
Mechanisms and Models for Elucidating the Cardiac Effects of Sphingosine 1‐Phosphate (S1P) (2013) (0)
Thrombin and M-3 muscarinic receptors utilize common pertussis toxin -insensitive signalling pathways, but have divergent effects on Ras, MAP kinase and DNA synthesis (1994) (0)
Endurance Training Abolish Arrhythmogenic Ca2+ Leak In Cardiomyocytes From Mice Over-expressing CaMKII (2009) (0)
P1797Calcium/calmodulin-dependent protein kinase II (CaMKII) initiates inflammation, inflammasome activation and immune cell infiltration in response to pressure overload through signaling in cardiomyocyte (2018) (0)
Animal Cytogenetics and Comparative Mapping (2003) (0)
RhoA activates protein kinase D leading to cardioprotection against ischemia/reperfusion (2011) (0)
Protective RhoA Signaling Regulates Drp1 and Mitochondrial Fission in Cardiomyocytes (2018) (0)
Reduced contractile response to α1-adrenergic stimulation in atria from mice with chronic cardiac CaMKII inhibition (2007) (0)
Glycopyrrolate as a Premedicant: Comparison with Atropine (1980) (0)
Ingibition of elastase and collagenase by anti-inflammatory drugs. (1970) (0)
Abstract 1067: CamKII Regulates NFAT Nuclear Translocation in a Calcineurin Independent Manner (2007) (0)
Functional Modulation of Cardiac ATP-Sensitive Potassium Channels by Nitric Oxide via Intracellular Signaling (2013) (0)
Effect of enzymatic functional group inhibitors on the esterases of Crotalus atrox venom. Rep No. 627. (1965) (0)
A new apparatus for determining oxygen consumption in rats. (1958) (0)
Circulation Research. (2016) (0)
Parasympathetic Effects on in Vivo Rat Heart Can Be Regulated Through an ax-Adrenergic Receptor (2005) (0)
Regulation of Glioblastoma Stem Cell Properties and Tumor Invasion by G⍺12 Signaling (2022) (0)
Chemotherapy on Harding-Passey melanoma with gladenine. Part I. (1976) (0)
Splicing and Dicing: A Deeper Dive Into CaMKIIδ and Cardiac Inflammation. (2022) (0)
Hyperglycemic and Hyperlactic Acidemic Effects of Soterenol (MJ 1992) (1969) (0)
Subcellular localization and activation of CaMKII delta splice variants (2010) (0)
Studies on the phospholipase A activity of Crotalus atrox venom.Rep No. 630. (1965) (0)
Akt mediates cardioprotection through phosphorylation of mitochondrial hexokinase-II (2007) (0)
Abstract 17464: RhoA Signaling Stabilizes PINK1 and Induces Mitophagy in Cardiomyocytes (2017) (0)
Overexpression of CaMKII (cid:1) c in RyR2 R4496C (cid:2) / (cid:3) Knock-In Mice Leads to Altered Intracellular Ca 2 (cid:2) Handling and Increased Mortality (2011) (0)
ATPase Inhibitor Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ (2021) (0)
GPCRs are regulators of MRTF‐A and YAP mediated CCN1 expression (1066.4) (2014) (0)
Phospholipase C‐epsilon links G‐protein coupled receptor activation to inflammatory responses in astrocytes (1066.5) (2014) (0)
Cardiomyocyte NLRP3 Contributes to the Cardiac Inflammatory Response (2021) (0)
CaMKII δ Deletion Protects Against Apoptosis In Myocardial Ischemia/Reperfusion Injury In Vivo (2008) (0)
0062 : C-terminal phosphorylation of Nav1.5 channels impairs FGF13-dependent inactivation: potential impact in heart failure (2016) (0)
The (cid:1) C Isoform of CaMKII Is Activated in Cardiac Hypertrophy and Induces Dilated Cardiomyopathy and Heart Failure (2003) (0)
Abstract 160: Cardiomyocyte CaMKII Mediates Expression of Pro-inflammatory Chemokines and Cytokines, Macrophage Infiltration and Cardiac Remodeling in Response to Pressure Overload (2017) (0)
Abstract 13658: Identification of Two Native Nav1.5 Phosphorylation Sites as Potential Determinants of the Increased Late Na+ Current in Heart Failure (2014) (0)
Agonist-induced GLUT1 expression and glucose uptake in neonatal rat cardiomyocytes: Dissociation from hypertrophy (2001) (0)
Phospholipase C‐epsilon Mediates Inflammatory Responses in Experimental Autoimmune Encephalomyelitis Progression through its Role in Astrocyte GPCR Signaling (2016) (0)
Abstract 16630: Role of GPCR Signaling in Cardiac Progenitor Cells (2012) (0)
Abstract 356: CaMKII Cytoplasmic and Nuclear Isoforms Differentially Affect Calcium Handling but Similarly Regulate HDAC/MEF2 Transcriptional Responses (2006) (0)
A Kinase Interacting Protein 1 (AKIP1) promotes cardiomyocyte elongation and physiological cardiac remodelling (2023) (0)
Abstract A19: Regulation of glioblastoma tumor growth and stem cell properties through Gα12 and tissue factor, upstream and downstream players in YAP signaling (2020) (0)
Phospholamban Ablation Rescues SR Ca2+ Loading But Not Cardiac Function In CaMKII{lambda}C Transgenic Mice (2006) (0)
Deletion of Cardiomyocyte YAP Potentiates Inflammatory Gene Expression in the Heart (2020) (0)
PLC{varepsilon} Selectively Transduces Thrombin Versus LPA Signals to Astrocyte Proliferation Through Rap1 and Rho (2008) (0)
PLCε Selectively Transduces Thrombin Versus LPA Signals to Astrocyte Proliferation Through Rap1 and Rho (2008) (0)
Mouse c‐kit+ Cardiac Progenitor Cells Do not Age Gracefully (2017) (0)
The role of phospholipase c‐epsilon in COX‐2 expression and inflammation (2012) (0)
Guanine nucleotide regulation of muscarinic receptor-mediated inositol phosphate formation in permeabilized 1321N1 cells (1986) (0)
chapter 7 – Cardiovascular Signaling Pathways (2004) (0)
CaMKII {delta} Deletion Protects Against Apoptosis In Myocardial Ischemia/Reperfusion Injury In Vivo (2008) (0)
Epac2 Mediates Cardiac (cid:533) 1 -Adrenergic Dependent SR Ca 2+ Leak and Arrhythmia (2013) (0)
and Expression in the Vasculature of Hypertensive RatsKip 1 and Reduced p 27 Increased Expression and Activity of RhoA Are Associated With Increased DNA Synthesis (2001) (0)
Abstract 626: Pro-Inflammatory Signaling by Cardiomyocytes Involves Activation of a RhoA Dependent Gene Expression Pathway (2019) (0)
Abstract 16820: CaMKIIδc Transgenic Mice Develop Spontaneous Ventricular Arrhythmias Which Can Be Suppressed by Inhibition of Late Na+ Current (2014) (0)
S10-2 Inhibitory Effect of Pulsatile Stretch on Thrombin-Induced RhoA Activation in Vascular Smooth Muscle Cells is Mediated by NO(Proceedings of The 8th International Congress of Physiological Anthropology) (2007) (0)
Abstract 313: Sphingosine-1-Phosphate and RhoA Signaling Regulate Dynamin-Related Protein 1 and Cardiac Mitochondrial Fission (2017) (0)
RhoA, phospholipase Cε and PKD signaling mediate S1P induced cardioprotection against ischemia/reperfusion (2012) (0)
RhoA mediates cardiomyocyte survival through FAK‐dependent Akt activation (2008) (0)
Production of inositol trisphosphates upon. cap alpha. -adrenergic stimulation in BC3H-1 muscle cells (1986) (0)
M1 muscarinic receptors transiently expressed in cardiac myocytes selectively regulate atrial natriuretic factor gene expression (1995) (0)
Increased Expression and Activity of RhoA Are Associated With Increased DNA Synthesis and Reduced p27 (2001) (0)
Thrombin mediated PAR1 stimulation results in sustained activation of Rap1 and downstream responses in human 1321N1 astroglioma cells (2010) (0)
Abstract 1377: PHLPP, a Novel Akt Phosphatase, Expressed and is Regulated in Cardiomyocytes (2006) (0)
Abstract 457: Ca2+/calmodulin Dependent Kinase II Exacerbates Heart Failure Progression Through Activation of Class I Histone Deacetylases (2018) (0)
Effect of low density lipoprotein on Rho‐dependent proliferation in vascular smooth muscle cells (2006) (0)
CaMKIId As a Nodal Mediator of Insulin Signaling and Adrenergic Signaling in Cardiomyocytes – a Signaling Network Map Profiling by Quantitative Phospho‐proteomics (2016) (0)
Calcium/Calmodulin-dependent Protein Kinase II (CaMKII) Signaling in Cardiomyocytes Initiates Inflammatory Gene Expression, Inflammasome Activation and Macrophage Accumulation Leading to Adverse Cardiac Remodeling in Response to Pressure Overload (2018) (0)
Role of calmodulin kinase II in inotropic effect of {alpha}1-adrenergic stimulation in the heart (2008) (0)
Role of calmodulin kinase II in inotropic effect of α1‐adrenergic stimulation in the heart (2008) (0)
Monophosphate Formation inIntact Retina (1972) (0)
Activated RhoA Induces Cardiomyocyte Apoptosis via a Mitochondrial Death Pathway (2006) (0)

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