JoAnn Trejo
#126,811
Most Influential Person Now
American academic pharmacologist
JoAnn Trejo's AcademicInfluence.com Rankings
JoAnn Trejomedical Degrees
Medical
#3572
World Rank
#4050
Historical Rank
#533
USA Rank
Pharmacology
#463
World Rank
#520
Historical Rank
#46
USA Rank
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Medical
JoAnn Trejo's Degrees
- PhD Pharmacology University of California, San Diego
- Bachelors Pharmacology University of California, San Diego
Why Is JoAnn Trejo Influential?
(Suggest an Edit or Addition)According to Wikipedia, JoAnn Trejo is an American pharmacologist, cell biologist, a professor, and also an assistant vice chancellor in the department of health sciences faculty affairs in the Department of Pharmacology at the School of Medicine at University of California, San Diego. She is also the assistant vice chancellor for Health Sciences Faculty Affairs. Trejo studies cell signalling by protease-activated G protein-coupled receptors . She is also actively involved in mentoring, education and outreach activities to increase the diversity of science.
JoAnn Trejo's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- G protein-coupled receptor sorting to endosomes and lysosomes. (2008) (452)
- Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway (1996) (270)
- Signal transduction by protease‐activated receptors (2010) (265)
- Clathrin‐Dependent Mechanisms of G Protein‐coupled Receptor Endocytosis (2007) (231)
- β-Arrestins Regulate Protease-activated Receptor-1 Desensitization but Not Internalization or Down-regulation* (2002) (227)
- Protease-activated receptor-2 is essential for factor VIIa and Xa-induced signaling, migration, and invasion of breast cancer cells. (2006) (203)
- Arrestin-2 Interacts with the Ubiquitin-Protein Isopeptide Ligase Atrophin-interacting Protein 4 and Mediates Endosomal Sorting of the Chemokine Receptor CXCR4* (2007) (190)
- The Cytoplasmic Tails of Protease-activated Receptor-1 and Substance P Receptor Specify Sorting to Lysosomes versusRecycling* (1999) (185)
- Protease-activated receptor signalling, endocytic sorting and dysregulation in cancer (2007) (159)
- Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1. (2002) (150)
- Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting. (1998) (146)
- ALIX binds a YPX3L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting (2012) (144)
- Role of the Thrombin Receptor's Cytoplasmic Tail in Intracellular Trafficking (1996) (141)
- The Cloned Thrombin Receptor Is Necessary and Sufficient for Activation of Mitogen-activated Protein Kinase and Mitogenesis in Mouse Lung Fibroblasts (1996) (139)
- Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffolds (2011) (138)
- An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins. (2005) (137)
- Caveolae are required for protease-selective signaling by protease-activated receptor–1 (2009) (136)
- PAR-1 contributes to the innate immune response during viral infection. (2013) (122)
- Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion (2008) (119)
- Protease-Activated Receptors: New Concepts in Regulation of G Protein-Coupled Receptor Signaling and Trafficking (2003) (118)
- A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking. (2004) (117)
- A direct role for protein kinase C and the transcription factor Jun/AP-1 in the regulation of the Alzheimer's beta-amyloid precursor protein gene. (1994) (115)
- Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis (2008) (114)
- Clathrin Adaptor AP2 Regulates Thrombin Receptor Constitutive Internalization and Endothelial Cell Resensitization (2006) (112)
- Protease-activated receptor signaling: new roles and regulatory mechanisms (2007) (110)
- Persistent Signaling by Dysregulated Thrombin Receptor Trafficking Promotes Breast Carcinoma Cell Invasion (2004) (109)
- Ubiquitination differentially regulates clathrin-dependent internalization of protease-activated receptor-1 (2007) (108)
- Multiple Independent Functions of Arrestins in the Regulation of Protease-Activated Receptor-2 Signaling and Trafficking (2005) (105)
- c-fos and c-jun are induced by muscarinic receptor activation of protein kinase C but are differentially regulated by intracellular calcium. (1991) (102)
- Thrombin Promotes Release of ATP from Lung Epithelial Cells through Coordinated Activation of Rho- and Ca2+-dependent Signaling Pathways* (2009) (100)
- Cofactoring and Dimerization of Proteinase-Activated Receptors (2013) (90)
- Transactivation of the PAR1-PAR2 Heterodimer by Thrombin Elicits β-Arrestin-mediated Endosomal Signaling* (2013) (83)
- Ubiquitin-dependent regulation of G protein-coupled receptor trafficking and signaling. (2013) (82)
- Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2. (2005) (82)
- Proteases display biased agonism at protease-activated receptors: location matters! (2009) (80)
- Termination of Protease-activated Receptor-1 Signaling by β-Arrestins Is Independent of Receptor Phosphorylation* (2004) (75)
- Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: differential effects of muscarinic and thrombin receptor activation (1992) (70)
- Protease-activated Receptor-1 Down-regulation (2000) (63)
- Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: Structural determinants of numb association with the cortical membrane. (2006) (62)
- Phosphorylation of Protease-activated Receptor-2 Differentially Regulates Desensitization and Internalization* (2009) (59)
- The Chemokine Receptor CCR1 Is Constitutively Active, Which Leads to G Protein-independent, β-Arrestin-mediated Internalization* (2013) (59)
- Adaptor Protein Complex-2 (AP-2) and Epsin-1 Mediate Protease-activated Receptor-1 Internalization via Phosphorylation- and Ubiquitination-dependent Sorting Signals* (2011) (59)
- Challenges and Opportunities in Protease-Activated Receptor Drug Development. (2017) (58)
- A Tyrosine-based Sorting Signal Regulates Intracellular Trafficking of Protease-activated Receptor-1 (2004) (58)
- The α-arrestin ARRDC3 mediates ALIX ubiquitination and G protein–coupled receptor lysosomal sorting (2015) (57)
- A requirement for membrane cholesterol in the β-arrestin- and clathrin-dependent endocytosis of LPA1 lysophosphatidic acid receptors (2005) (55)
- Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes (2015) (55)
- AP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway (2012) (53)
- GPCRs in Cancer: Protease-Activated Receptors, Endocytic Adaptors and Signaling (2018) (53)
- Post-Translational Modifications of G Protein–Coupled Receptors Control Cellular Signaling Dynamics in Space and Time (2020) (46)
- The unfolded protein response regulator ATF6 promotes mesodermal differentiation (2018) (46)
- Ubiquitination of G Protein-Coupled Receptors: Functional Implications and Drug Discovery (2012) (46)
- N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias (2015) (45)
- Novel Roles for the E3 Ubiquitin Ligase Atrophin-interacting Protein 4 and Signal Transduction Adaptor Molecule 1 in G Protein-coupled Receptor Signaling* (2012) (44)
- ALIX Regulates the Ubiquitin-Independent Lysosomal Sorting of the P2Y1 Purinergic Receptor via a YPX3L Motif (2016) (38)
- Endo‐lysosomal sorting of G‐protein‐coupled receptors by ubiquitin: Diverse pathways for G‐protein‐coupled receptor destruction and beyond (2018) (37)
- Internal PDZ Ligands: Novel Endocytic Recycling Motifs for G Protein-Coupled Receptors (2005) (36)
- N-Linked Glycosylation of Protease-activated Receptor-1 Second Extracellular Loop (2010) (34)
- Protease-activated receptor-4 and purinergic receptor P2Y12 dimerize, co-internalize, and activate Akt signaling via endosomal recruitment of β-arrestin (2017) (33)
- A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling (2018) (30)
- The α-arrestin ARRDC3 suppresses breast carcinoma invasion by regulating G protein–coupled receptor lysosomal sorting and signaling (2018) (28)
- A General Method for Site Specific Fluorescent Labeling of Recombinant Chemokines (2014) (27)
- A MUTANT HeLa CELL LINE SUGGESTS NOVEL REQUIREMENTS FOR PAR1 PHOSPHORYLATION AND RECRUITMENT TO CLATHRIN-COATED PITS* (2000) (27)
- Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins* (2015) (26)
- G protein–coupled receptors activate p38 MAPK via a non-canonical TAB1–TAB2– and TAB1–TAB3–dependent pathway in endothelial cells (2019) (25)
- Characterization of Thrombin-Bound Dabigatran Effects on Protease-Activated Receptor-1 Expression and Signaling In Vitro (2015) (24)
- Atypical regulation of G protein-coupled receptor intracellular trafficking by ubiquitination. (2014) (22)
- Integration of endothelial protease-activated receptor-1 inflammatory signaling by ubiquitin (2016) (22)
- Signaling diversity enabled by Rap1-regulated plasma membrane ERK with distinct temporal dynamics (2019) (22)
- Group B Streptococcal Infection and Activation of Human Astrocytes (2015) (20)
- Palmitoylation of Protease-activated Receptor-1 Regulates Adaptor Protein Complex-2 and -3 Interaction with Tyrosine-based Motifs and Endocytic Sorting* (2013) (19)
- Protease-activated Receptor-4 Signaling and Trafficking Is Regulated by the Clathrin Adaptor Protein Complex-2 Independent of β-Arrestins* (2016) (18)
- Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function (2020) (18)
- Subcellular hot spots of GPCR signaling promote vascular inflammation (2020) (18)
- Allosteric modulation of protease-activated receptor signaling. (2012) (17)
- RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling. (2010) (16)
- Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus (2020) (16)
- Endosomal signaling by protease-activated receptors. (2014) (16)
- Regulation of Protease-activated Receptor 1 Signaling by the Adaptor Protein Complex 2 and R4 Subfamily of Regulator of G Protein Signaling Proteins* (2013) (16)
- Regulation of protease‐activated receptor signaling by post‐translational modifications (2011) (14)
- Cryptic messages: Is noncoagulant tissue factor reserved for cell signaling? (2006) (13)
- α-arrestin ARRDC3 tumor suppressor function is linked to GPCR-induced TAZ activation and breast cancer metastasis. (2021) (12)
- Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development. (2015) (11)
- GPCR sorting at multivesicular endosomes. (2015) (9)
- Heat shock protein 27 activity is linked to endothelial barrier recovery after proinflammatory GPCR-induced disruption (2021) (8)
- Multiple pathways for signal transduction through the muscarinic cholinergic receptor. (1990) (6)
- A modular laboratory course using planarians to study genes involved in tissue regeneration (2019) (4)
- Proteinase-activated receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (3)
- Dysregulation of G Protein-Coupled Receptor Signaling in Cancer (2010) (3)
- The α-arrestin ARRDC3 is an Emerging Multifunctional Adaptor Protein in Cancer. (2021) (3)
- aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete β-arrestin-2 mediated SphK1-S1PR1-Akt signaling axis (2021) (3)
- Regulation of Thrombin Receptor Signaling (2009) (3)
- Regulation of GPCR activation of the Hippo pathway in metastatic breast cancer (2020) (2)
- aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2–mediated SphK1-S1PR1-Akt signaling axis (2021) (2)
- GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes (2020) (1)
- Ubiquitination of PAR1 nucleates a non‐canonical p38 signaling pathway to regulate thrombin‐induced vascular leakage (1066.15) (2014) (1)
- Regulation of alpha‐Arrestin Function in G Protein‐Coupled Receptor Signaling and Trafficking (2020) (1)
- Phospho‐proteomic Analysis of Protease‐activated Receptor‐1 Biased Signaling Reveals Novel Modulators of Endothelial Barrier Function (2020) (1)
- Phosphoproteomic analysis of thrombin- and p38 MAPK-regulated signaling networks in endothelial cells (2022) (1)
- Breast Cancer Cells Induced Signaling , Migration , and Invasion of − and Xa Protease-Activated Receptor-2 Is Essential for Factor VIIa (2005) (1)
- Tumor Suppressor Alpha‐arrestin ARRDC3 Controls GPCR Signaling and Breast Cancer Invasion (2018) (0)
- The α‐Arrestin ARRDC3 Suppresses Breast Carcinoma Invasion by Regulating GPCR Lysosomal Sorting and Signaling (2018) (0)
- Proteinase-activated receptors in GtoPdb v.2021.3 (2021) (0)
- Regulation of GPCR‐induced Hippo pathway signaling by ARRDC3 in breast carcinoma (2022) (0)
- Ubiquitin and intracellular signaling by G protein‐coupled receptors (354.2) (2014) (0)
- An siRNA screen for endothelial PAR1‐specific deubiquitinases regulating p38 inflammatory signaling (2020) (0)
- Regulation of protease‐activated receptor‐4 signaling and trafficking (2012) (0)
- Identification of Deubiquitinases (DUBs) that modulate PAR1‐mediated p38 MAPK inflammatory signaling in endothelial cells (2022) (0)
- Rab11A and Rab11B distinctly regulate protease‐activated receptor‐1 recycling and constitutive degradation (802.10) (2014) (0)
- Internalization of Protease‐Activated Receptor 4 is AP‐2 Dependent and Utilizes a Non‐canonical Sorting Motif (2016) (0)
- An siRNA library screen for endothelial PAR1‐specific deubiquitinases regulating p38 MAPK inflammatory signaling (2022) (0)
- Glycosylation of protease‐activated receptor‐1 regulates G12/13 versus Gq signal pathway bias (1066.13) (2014) (0)
- - Arrestin-mediated Endosomal Signaling β Heterodimer by Thrombin Elicits Transactivation of the PAR 1-PAR 2 Signal Transduction : (2013) (0)
- Improved fractionation method demonstrates phosphorylated Akt is localized to the cytoplasm in LβT2 cells (2020) (0)
- Diminished neuronal ESCRT-0 function exacerbates AMPA receptor derangement and accelerates prion-induced neurodegeneration. (2023) (0)
- G Protein‐Coupled Receptor Regulation of the alpha‐Arrestin ARRDC3 (2021) (0)
- Teasing a(PAR)t biased‐agonism: Protease‐activated Receptor‐1 at signaling crossroads in endothelial barrier function (2011) (0)
- Palmitoylation is required for activated PAR1 ubiquitination and p38 MAPK signaling (1066.16) (2014) (0)
- Activated protein C promotes endothelial barrier protection through biased PAR1 signaling mediated by β‐arrestin and dishevelled‐2 scaffolds (2012) (0)
- Regulation of protease‐activated receptor‐1 signaling and trafficking by extracellular loop 2 N‐linked glycosylation (2012) (0)
- Exploring GPCR Biased Signaling from inside and outside the Cell (2015) (0)
- Evaluation of the antinociceptive effects of tramadol in co-administration with diclofenac intraperitoneally in mice (2011) (0)
- Integration of GPCR‐induced endothelial cytoprotection signaling by β‐arrestin‐2 (2020) (0)
- ALIX interacts with a YPX3L motif of Protease‐Activated Receptor 1 and mediates MVB/Lysosomal sorting through an ESCRT‐III‐dependent pathway independent of ubiquitination (2012) (0)
- N‐linked glycosylation of protease‐activated receptor‐1 regulates receptor activation and internalization (2011) (0)
- Thrombin‐bound dabigatran modulates protease‐activated receptor‐1 expression (1066.14) (2014) (0)
- Characterization of group B streptococcal infection of astrocytes and the impact on the blood‐brain barrier (145.8) (2014) (0)
- The α‐arrestin ARRDC3 regulates ubiquitin‐independent ALIX‐mediated GPCR lysosomal sorting (783.2) (2014) (0)
- Abstract A16: The α-arrestin ARRDC3 functions as a metastasis suppressor by regulating GPCR activation of the Hippo pathway (2020) (0)
- Role of Protease‐activated receptors in Activated protein C‐mediated anti‐inflammatory responses in endothelial cells (2020) (0)
- Endothelial GPCRs Activate p38 MAPK Inflammatory Signaling Via Non‐canonical TAB1, 2 and 3‐dependent Pathways (2018) (0)
- A Novel Lysosomal GPCR Sorting Pathway Regulated by Alpha‐arrestins and ALIX (2016) (0)
- Membrane Microdomains and Protease-Dependent Biased Agonism (2009) (0)
- The Photoreceptor Dystrophy and Unfolded Protein Response Regulator Gene, ATF6, Promotes Mesodermal Differentiation in Human Stem Cells (2018) (0)
- Endosomal GPCR signaling: Tyrosine Phosphorylation of a Peptide Linker in NEDD4‐2 Increases Ligase Activity to Promote p38 Proinflammatory Signaling (2018) (0)
- Regulation of ALIX ubiquitination and function in GPCR lysosomal sorting by the alpha‐arrestin ARRDC3 (604.3) (2014) (0)
- Protease-activated receptor-4 and P2Y12 Dimerize, Co-Internalize and Activate Akt Signaling via Endosomal Recruitment of b -arrestin (2017) (0)
- G‐protein coupled receptor kinases’ (GRKs) role in APC/PAR1‐induced endothelial cells (2020) (0)
- G protein‐coupled receptor regulation of the alpha‐arrestin ARRDC3 (2022) (0)
- aPC/PAR1 confers endothelial anti‐apoptotic activity via a discrete β‐arrestin‐2 mediated SphK1‐S1PR1‐Akt signaling axis (2022) (0)
- Regulation of activated Protein C/PAR1 endothelial cytoprotective signaling by G protein‐coupled receptor kinases (2022) (0)
- Signaling Diversity Enabled by Rap1 and cAMP/PKA‐Regulated Plasma Membrane ERK with Distinct Temporal Dynamics (2020) (0)
- MON-009 GLUT1-Mediated Glycolysis Facilitates GnRH-Induced Secretion of Luteinizing Hormone (2020) (0)
- a‐arrestin ARRDC3 is a Multifunctional Adaptor That Regulates G Protein‐Coupled Receptor Signaling and Breast Cancer Invasion (2020) (0)
- Palmitoylation of protease‐activated receptor‐1: regulation of receptor ubiquitination and intracellular trafficking (2011) (0)
- Activated Protein C‐mediated Crosstalk Between PAR1 and S1PR1 in Endothelial Barrier Stabilization (2018) (0)
- Protease-activated receptor-4 and purinergic receptor P2Y12 dimerize, co-internalize, and activate Akt signaling via endosomal recruitment of (cid:2) -arrestin (2017) (0)
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