Joanne Lemieux
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Molecular Biology
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Chemistry Biology
Why Is Joanne Lemieux Influential?
(Suggest an Edit or Addition)According to Wikipedia, M. Joanne Lemieux is a Canadian scientist who is a Professor of Structural Biology at the University of Alberta. She studies the structures of membrane proteins that are critical to disease in an effort to identify novel therapeutic strategies. During the COVID-19 pandemic Lemieux worked to develop an antiviral drug that could protect people from coronavirus disease.
Joanne Lemieux's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Structure and Mechanism of the Glycerol-3-Phosphate Transporter from Escherichia coli (2003) (1008)
- Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication (2020) (270)
- CLK‐1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans (1999) (264)
- Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis. (2006) (154)
- The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis (2007) (149)
- Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory (2015) (119)
- Three‐dimensional crystallization of the Escherichia coli glycerol‐3‐phosphate transporter: A member of the major facilitator superfamily (2003) (104)
- High-yield expression and functional analysis of Escherichia coli glycerol-3-phosphate transporter. (2001) (86)
- Glycerol-3-phosphate transporter of Escherichia coli: structure, function and regulation. (2004) (83)
- Proline residues in transmembrane segment IV are critical for activity, expression and targeting of the Na+/H+ exchanger isoform 1. (2004) (83)
- Practical aspects of overexpressing bacterial secondary membrane transporters for structural studies. (2003) (82)
- The structural basis of substrate translocation by the Escherichia coli glycerol-3-phosphate transporter: a member of the major facilitator superfamily. (2004) (70)
- Comprehensive in vitro characterization of PD-L1 small molecule inhibitors (2019) (68)
- Allosteric regulation of rhomboid intramembrane proteolysis (2014) (67)
- Importance of detergent and phospholipid in the crystallization of the human erythrocyte anion-exchanger membrane domain. (2002) (66)
- Properties and Biotechnological Applications of Acyl-CoA:diacylglycerol Acyltransferase and Phospholipid:diacylglycerol Acyltransferase from Terrestrial Plants and Microalgae. (2018) (58)
- Eukaryotic major facilitator superfamily transporter modeling based on the prokaryotic GlpT crystal structure (Review) (2007) (48)
- Regulation of physiological rates in Caenorhabditis elegans by a tRNA-modifying enzyme in the mitochondria. (2001) (44)
- Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability (2021) (40)
- Diacylglycerol Acyltransferase 1 Is Regulated by Its N-Terminal Domain in Response to Allosteric Effectors1[OPEN] (2017) (40)
- Domain swapping in the cytoplasmic domain of the Escherichia coli rhomboid protease. (2013) (38)
- Insights into substrate gating in H. influenzae rhomboid. (2011) (38)
- Crystal structure and mechanism of GlpT, the glycerol-3-phosphate transporter from E. coli. (2005) (32)
- Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies (2021) (32)
- Biochemical characterization and structure-function relationship of two plant NCS2 proteins, the nucleobase transporters NAT3 and NAT12 from Arabidopsis thaliana. (2014) (31)
- Understanding Conformational Dynamics of Complex Lipid Mixtures Relevant to Biology (2018) (30)
- Untangling structure-function relationships in the rhomboid family of intramembrane proteases. (2013) (28)
- Oligomeric state study of prokaryotic rhomboid proteases. (2012) (27)
- A genetically encoded fluorescent biosensor for extracellular l-lactate (2021) (27)
- Targeting B7‐1 in immunotherapy (2020) (26)
- Rapid expression screening of eukaryotic membrane proteins in Pichia pastoris (2013) (26)
- Structure-Function Relationship of a Plant NCS1 Member – Homology Modeling and Mutagenesis Identified Residues Critical for Substrate Specificity of PLUTO, a Nucleobase Transporter from Arabidopsis (2014) (26)
- Reactions at Biomembrane Interfaces. (2019) (25)
- The Phospholamban Pentamer Alters Function of the Sarcoplasmic Reticulum Calcium Pump SERCA. (2019) (24)
- Purification and properties of recombinant Brassica napus diacylglycerol acyltransferase 1 (2015) (24)
- Diacylglycerol acyltransferase 1 is activated by phosphatidate and inhibited by SnRK1-catalyzed phosphorylation. (2018) (24)
- The structure of lactoferrin-binding protein B from Neisseria meningitidis suggests roles in iron acquisition and neutralization of host defences. (2014) (22)
- Multiple mechanisms contribute to increased neutral lipid accumulation in yeast producing recombinant variants of plant diacylglycerol acyltransferase 1 (2017) (18)
- Genetic variation in human carboxylesterase CES1 confers resistance to hepatic steatosis. (2018) (18)
- Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors. (2021) (17)
- PARL Protease: A Glimpse at Intramembrane Proteolysis in the Inner Mitochondrial Membrane. (2020) (17)
- SARS-COV-2 recombinant Receptor-Binding-Domain (RBD) induces neutralizing antibodies against variant strains of SARS-CoV-2 and SARS-CoV-1 (2021) (16)
- Conformational memory in the association of the transmembrane protein phospholamban with the sarcoplasmic reticulum calcium pump SERCA (2017) (16)
- Fluorescent Hexose Conjugates Establish Stringent Stereochemical Requirement by GLUT5 for Recognition and Transport of Monosaccharides. (2017) (16)
- Crystal structure of the N-lobe of lactoferrin binding protein B from Moraxella bovis. (2012) (16)
- Quantitative Multiplex Substrate Profiling of Peptidases by Mass Spectrometry* (2019) (16)
- Vitamin D is an endogenous partial agonist of the transient receptor potential vanilloid 1 channel (2020) (14)
- Regulation of 2',3'-cyclic nucleotide phosphodiesterase gene expression in experimental peripheral neuropathies. (1992) (13)
- Critical Roles of Two Hydrophobic Residues within Human Glucose Transporter 9 (hSLC2A9) in Substrate Selectivity and Urate Transport* (2015) (13)
- The crystal structure of Rv0793, a hypothetical monooxygenase from M.␣tuberculosis (2006) (13)
- N-Terminal Finger Stabilizes the S1 Pocket for the Reversible Feline Drug GC376 in the SARS-CoV-2 Mpro Dimer (2021) (12)
- Acyl-CoA:diacylglycerol acyltransferase: Properties, physiological roles, metabolic engineering and intentional control. (2022) (12)
- Interaction of a sarcolipin pentamer and monomer with the sarcoplasmic reticulum calcium pump, SERCA (2019) (12)
- Deciphering the activation and recognition mechanisms of Staphylococcus aureus response regulator ArlR (2019) (11)
- Dwarf open reading frame (DWORF) is a direct activator of the sarcoplasmic reticulum calcium pump SERCA (2021) (11)
- An internally quenched peptide as a new model substrate for rhomboid intramembrane proteases (2018) (11)
- Author Correction: Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication (2020) (10)
- High yield expression and purification of equilibrative nucleoside transporter 7 (ENT7) from Arabidopsis thaliana. (2015) (10)
- Intrinsic disorder in the regulatory N-terminal domain of diacylglycerol acyltransferase 1 from Brassica napus (2018) (10)
- Reversible Unfolding of Rhomboid Intramembrane Proteases. (2016) (10)
- Insights into the catalytic properties of the mitochondrial rhomboid protease PARL (2020) (9)
- Crystallographic structure of human beta-Hexosaminidase A (2006) (9)
- Purification and characterization of transporter proteins from human erythrocyte membrane. (2003) (8)
- Identification of Key Residues for Urate Specific Transport in Human Glucose Transporter 9 (hSLC2A9) (2017) (8)
- Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli (2003) (8)
- Photocleavable proteins that undergo fast and efficient dissociation† (2021) (8)
- The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C (2018) (7)
- Dwarf open reading frame (DWORF) peptide is a direct activator of the sarcoplasmic reticulum calcium pump SERCA (2020) (7)
- Probing catalytic rate enhancement during intramembrane proteolysis (2016) (6)
- Trimeric structure of the mouse Kupffer cell C‐type lectin receptor Clec4f (2020) (6)
- Structural comparison of substrate entry gate for rhomboid intramembrane peptidases. (2011) (6)
- Crystal structure of the N-lobe of lactoferrin binding protein B from Moraxella bovis 11 (2012) (5)
- A perspective on the structural studies of inner membrane electrochemical potential-driven transporters. (2008) (5)
- Structural insights into the feline coronavirus drug GC376, which inhibits the main protease of SARS-CoV-2 and blocks virus replication (2020) (5)
- A sensitive and specific genetically-encoded potassium ion biosensor for in vivo applications across the tree of life (2022) (4)
- Structure and function of proteins in membranes and nanodiscs (2020) (4)
- Improved Photocleavable Proteins with Faster and More Efficient Dissociation (2020) (4)
- Accelerated discovery of novel glycoside hydrolases using targeted functional profiling and selective pressure on the rumen microbiome (2021) (4)
- Quantitative Multiplex Substrate Profiling of Peptidases by Mass Spectrometry. (2019) (3)
- A sensitive and specific genetically encodable biosensor for potassium ions (2021) (3)
- Regulating the regulator: intramembrane proteolysis of vesicular trafficking proteins and the SERCA regulator phospholamban (2019) (3)
- Post-translational modifications of apolipoprotein A-I and Po proteins in the avian peripheral nerve (1995) (3)
- Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory (2015) (3)
- Production Data Indicate Reservoir and Fracture Performance in the Spraberry (1992) (2)
- Expression and Purification of Haemophilus influenzae Rhomboid Intramembrane Protease GlpG for Structural Studies (2014) (2)
- Activity Assays for Rhomboid Proteases. (2017) (2)
- 258-LB: Vitamin D Directly Regulates TRPV1 Channel Activity and May Play an Important Role in the Autoimmune Disease of Type 1 Diabetes (2019) (2)
- Highlight: Frontiers in Proteolysis (2018) (2)
- N-Terminal finger stabilizes the reversible feline drug GC376 in SARS-CoV-2 Mpro (2021) (2)
- SARS-CoV-2 Mpro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals (2023) (1)
- Accelerated discovery of novel glycoside hydrolases using targeted functional profiling and selective pressure on the rumen microbiome (2021) (1)
- The phospholamban pentamer interacts with the sarcoplasmic reticulum calcium pump SERCA (2018) (1)
- Understanding Structural and Functional Stability of two Rhomboid Proteases: HiGlpG and PsAarA (2016) (1)
- Expression and Purification of Human Mitochondrial Intramembrane Protease PARL. (2021) (1)
- Primitive Phospholamban- and Sarcolipin-like Peptides Inhibit the Sarcoplasmic Reticulum Calcium Pump SERCA. (2022) (1)
- The mechanism of dwarf open reading frame (DWORF) activation of the sarcoplasmic reticulum calcium pump SERCA. (2023) (0)
- Intrinsic disorder in the regulatory N-terminal domain of diacylglycerol acyltransferase 1 from Brassica napus (2018) (0)
- Opening the Lateral Gate of the Rhomboid Protease Couples to Lipid Binding (2015) (0)
- Targeting obesity-related inflammation through nutritional and genetic approaches (2015) (0)
- Functional Implications of Domain Organization Within Prokaryotic Rhomboid Proteases. (2015) (0)
- The Phospholamban Pentamer Functionally Interacts with the Sarcoplasmic Reticulum Calcium Pump SERCA (2019) (0)
- Influence of Familial Parkinson's Disease Mutations on Mitochondrial Localization and Secondary Structure of PINK1 (2016) (0)
- Author response: Dwarf open reading frame (DWORF) is a direct activator of the sarcoplasmic reticulum calcium pump SERCA (2021) (0)
- N-terminal finger stabilizes feline drug GC376 in coronavirus 3CL protease (2021) (0)
- X-ray crystal structure of NGT-bound HexA (2006) (0)
- Structural studies towards the development of an oral main protease (Mpro) inhibitor to treat SARS-CoV-2 infection (2021) (0)
- Crystal structure of GlpG, Rhomboid Peptidase from Haemophilus influenzae (2006) (0)
- Biosynthesis and Compartmentalization of Po, Apolipoprotein A-I, and Lipids in the Myelinating Sciatic Nerve Chick (1995) (0)
- Short-term effects of protein preload on gastroenteropancreatic appetite hormones and postprandial glycemia in Polycystic Ovarian Syndrome (PCOS) (2018) (0)
- Taking a position on intramembrane proteolysis (2018) (0)
- Understanding Conformational Dynamics of Complex Lipid Mixtures Relevant to Biology (2018) (0)
- Photocleavable Fluorescent Protein in green form (2021) (0)
- STRUCTURE OF THE LBPB N-LOBE FROM NEISSERIA MENINGITIDIS (2014) (0)
- Structure of Rv0793 from Mycobacterium tuberculosis (2004) (0)
- Crystal structure of H. influenzae rhomboid GlpG with disordered loop 4, helix 5 and loop 5 (2011) (0)
- SARS-CoV-2 Mpro protease variants of concern display altered viral and host target processing but retain potency towards antivirals (2023) (0)
- Production of Recombinant Rhomboid Proteases. (2017) (0)
- Structure of SARS-CoV2 3CL protease covalently bound to peptidomimetic inhibitor (2021) (0)
- Molecular basis for Tay-Sachs revealed by the crystal structure of human β-hexosaminidaseA (2005) (0)
- Sarcolambans are phospholamban- and sarcolipin-like regulators of the sarcoplasmic reticulum calcium pump SERCA (2020) (0)
- Biosynthesis and compartmentalization of Po, apolipoprotein A-I, and lipids in the myelinating chick sciatic nerve (1995) (0)
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