JoAnne Stubbe

Q: What Schools Are Affiliated With JoAnne Stubbe

JoAnne Stubbe is affiliated with the following schools: University of California, Berkeley, Williams College, Free University of Berlin, University of Wisconsin–Madison, Massachusetts Institute of Technology, Pennsylvania State University, University of Pennsylvania

JoAnne Stubbe's AcademicInfluence.com Rankings

JoAnne Stubbe

Chemistry

#284

World Rank

#566

Historical Rank

#144

USA Rank

chemistry Degrees

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Chemistry

JoAnne Stubbe's Degrees

PhD Chemistry University of California, Berkeley
Bachelors Chemistry Pennsylvania State University

Why Is JoAnne Stubbe Influential?

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According to Wikipedia, JoAnne Stubbe is an American chemist best known for her work on ribonucleotide reductases, for which she was awarded the National Medal of Science in 2009. In 2017, she retired as a Professor of Chemistry and Biology at the Massachusetts Institute of Technology.

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JoAnne Stubbe's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Protein Radicals in Enzyme Catalysis. (1998) (1126)
Mechanisms of bleomycin-induced DNA degradation (1987) (638)
Radical initiation in the class I ribonucleotide reductase: long-range proton-coupled electron transfer? (2003) (625)
Bleomycins: towards better therapeutics (2005) (541)
Phage auxiliary metabolic genes and the redirection of cyanobacterial host carbon metabolism. (2011) (356)
Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster. (2010) (264)
Thiyl Radicals in Ribonucleotide Reductases (1996) (243)
Mechanism of assembly of the tyrosyl radical-dinuclear iron cluster cofactor of ribonucleotide reductase. (1991) (240)
Proton-coupled electron transfer: the mechanistic underpinning for radical transport and catalysis in biology (2006) (232)
2'-Deoxy-2'-methylenecytidine and 2'-deoxy-2',2'-difluorocytidine 5'-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase. (1991) (224)
Ribonucleotide reductases: amazing and confusing. (1990) (210)
Overexpression and purification of the soluble polyhydroxyalkanoate synthase from Alcaligenes eutrophus: evidence for a required posttranslational modification for catalytic activity. (1994) (209)
Reversible, long-range radical transfer in E. coli class Ia ribonucleotide reductase. (2013) (201)
Binuclear Manganese(III) Complexes of Potential Biological Significance (1987) (197)
PHA synthase activity controls the molecular weight and polydispersity of polyhydroxybutyrate in vivo (1997) (193)
A model for the role of multiple cysteine residues involved in ribonucleotide reduction: amazing and still confusing. (1992) (183)
Class I ribonucleotide reductases: metallocofactor assembly and repair in vitro and in vivo. (2011) (175)
The crystal structure of class II ribonucleotide reductase reveals how an allosterically regulated monomer mimics a dimer (2002) (174)
Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways (2003) (164)
Protein radical involvement in biological catalysis? (1989) (155)
The Ralstonia eutropha PhaR Protein Couples Synthesis of the PhaP Phasin to the Presence of Polyhydroxybutyrate in Cells and Promotes Polyhydroxybutyrate Production (2002) (153)
Ribonucleotide reductases: radical enzymes with suicidal tendencies. (1995) (150)
Reconsideration of X, the Diiron Intermediate Formed during Cofactor Assembly in E. coli Ribonucleotide Reductase (1996) (148)
Stereochemical studies of the beta-elimination reactions at aldehydic abasic sites in DNA: endonuclease III from Escherichia coli, sodium hydroxide, and Lys-Trp-Lys. (1991) (145)
Polyhydroxyalkanoate (PHA) homeostasis: the role of the PHA synthase (2003) (141)
Nontemplate-dependent polymerization processes: polyhydroxyalkanoate synthases as a paradigm. (2005) (140)
New Insight into the Role of the PhaP Phasin of Ralstonia eutropha in Promoting Synthesis of Polyhydroxybutyrate (2001) (138)
Class I and III polyhydroxyalkanoate synthases from Ralstonia eutropha and Allochromatium vinosum: characterization and substrate specificity studies. (2001) (136)
Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase. (2008) (130)
High-field pulsed electron–electron double resonance spectroscopy to determine the orientation of the tyrosyl radicals in ribonucleotide reductase (2006) (128)
Structural Basis for Activation of Class Ib Ribonucleotide Reductase (2010) (125)
Kinetic Studies of Polyhydroxybutyrate Granule Formation in Wautersia eutropha H16 by Transmission Electron Microscopy (2005) (124)
BLEOMYCINS : A STRUCTURAL MODEL FOR SPECIFICITY, BINDING, AND DOUBLE STRAND CLEAVAGE (1996) (124)
Mechanism of Assembly of the Tyrosyl Radical-Diiron(III) Cofactorof E. coli Ribonucleotide Reductase. 3. Kinetics of the Limiting Fe2+ Reaction by Optical, EPR, and Moessbauer Spectroscopies (1994) (123)
Site-specific insertion of 3-aminotyrosine into subunit alpha2 of E. coli ribonucleotide reductase: direct evidence for involvement of Y730 and Y731 in radical propagation. (2007) (123)
An active dimanganese(III)-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase. (2010) (118)
Harnessing free radicals: formation and function of the tyrosyl radical in ribonucleotide reductase. (1998) (118)
Mono-, di-, tri-, and tetra-substituted fluorotyrosines: new probes for enzymes that use tyrosyl radicals in catalysis. (2006) (118)
An ENDOR study of the tyrosyl free radical in ribonucleotide reductase from Escherichia coli (1989) (117)
Ralstonia eutropha H16 Encodes Two and Possibly Three Intracellular Poly[d-(−)-3-Hydroxybutyrate] Depolymerase Genes (2003) (116)
Mechanism of Assembly of the Tyrosyl Radical-Diiron(III) Cofactor of E. Coli Ribonucleotide Reductase: 1. Moessbauer Characterization of the Diferric Radical Precursor (1994) (114)
Mechanistic studies on bleomycin-mediated DNA damage: multiple binding modes can result in double-stranded DNA cleavage (2008) (114)
Enhanced subunit interactions with gemcitabine-5′-diphosphate inhibit ribonucleotide reductases (2007) (111)
Pre-steady-state and steady-state kinetic analysis of E. coli class I ribonucleotide reductase. (2003) (111)
Accumulation of the PhaP Phasin of Ralstonia eutropha Is Dependent on Production of Polyhydroxybutyrate in Cells (2001) (109)
The mechanism of free base formation from DNA by bleomycin. A proposal based on site specific tritium release from Poly(dA.dU). (1983) (109)
Metallation and mismetallation of iron and manganese proteins in vitro and in vivo: the class I ribonucleotide reductases as a case study. (2012) (109)
Immunocytochemical analysis of poly-beta-hydroxybutyrate (PHB) synthase in Alcaligenes eutrophus H16: localization of the synthase enzyme at the surface of PHB granules (1993) (107)
Di-iron-tyrosyl radical ribonucleotide reductases. (2003) (107)
pH Rate profiles of FnY356-R2s (n = 2, 3, 4) in Escherichia coli ribonucleotide reductase: evidence that Y356 is a redox-active amino acid along the radical propagation pathway. (2006) (105)
Lipases provide a new mechanistic model for polyhydroxybutyrate (PHB) synthases: characterization of the functional residues in Chromatium vinosum PHB synthase. (2000) (99)
Coenzyme B12-dependent ribonucleotide reductase: evidence for the participation of five cysteine residues in ribonucleotide reduction. (1994) (99)
High-field EPR detection of a disulfide radical anion in the reduction of cytidine 5'-diphosphate by the E441Q R1 mutant of Escherichia coli ribonucleotide reductase. (1999) (99)
Polyhydroxybutyrate Synthase: Evidence for Covalent Catalysis (1996) (97)
Pulsed electron-nuclear double resonance (ENDOR) at 140 GHz. (1999) (95)
Characterization of C439SR1, a mutant of Escherichia coli ribonucleotide diphosphate reductase: evidence that C439 is a residue essential for nucleotide reduction and C439SR1 is a protein possessing novel thioredoxin-like activity. (1992) (93)
Mechanistic studies on class I polyhydroxybutyrate (PHB) synthase from Ralstonia eutropha: class I and III synthases share a similar catalytic mechanism. (2001) (89)
Incorporation of fluorotyrosines into ribonucleotide reductase using an evolved, polyspecific aminoacyl-tRNA synthetase. (2011) (89)
EXAFS Characterization of the Intermediate X Generated During the Assembly of the Escherichia coli Ribonucleotide Reductase R2 Diferric Tyrosyl Radical Cofactor (1998) (89)
PHA synthase from chromatium vinosum: cysteine 149 is involved in covalent catalysis. (1999) (88)
Sequence-specific double-strand cleavage of DNA by Fe-bleomycin. 2. Mechanism and dynamics. (1995) (88)
EPR distance measurements support a model for long-range radical initiation in E. coli ribonucleotide reductase. (2005) (87)
Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase (2011) (87)
Ribonucleotide reductases in the twenty-first century. (1998) (86)
Site-specific replacement of Y356 with 3,4-dihydroxyphenylalanine in the beta2 subunit of E. coli ribonucleotide reductase. (2006) (86)
N5-carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli. (1994) (85)
On the mechanism of ribonucleoside diphosphate reductase from Escherichia coli. Evidence for 3'-C--H bond cleavage. (1983) (85)
Mechanism of assembly of the dimanganese-tyrosyl radical cofactor of class Ib ribonucleotide reductase: enzymatic generation of superoxide is required for tyrosine oxidation via a Mn(III)Mn(IV) intermediate. (2013) (84)
Ribonucleotide reductases: the link between an RNA and a DNA world? (2000) (84)
Mechanism of bleomycin: evidence for a rate-determining 4'-hydrogen abstraction from poly(dA-dU) associated with the formation of both free base and base propenal. (1985) (80)
Cloning, sequencing, and expression of the adenosylcobalamin-dependent ribonucleotide reductase from Lactobacillus leichmannii. (1993) (80)
The evolution of ribonucleotide reduction revisited. (2001) (80)
High-frequency (139.5 GHz) EPR spectroscopy of the tyrosyl radical in Escherichia coli ribonucleotide reductase (1993) (79)
Site-specific incorporation of 3-nitrotyrosine as a probe of pKa perturbation of redox-active tyrosines in ribonucleotide reductase. (2010) (77)
Investigation of the mechanism of phosphoribosylamine transfer from glutamine phosphoribosylpyrophosphate amidotransferase to glycinamide ribonucleotide synthetase. (1995) (76)
Modular evolution of the purine biosynthetic pathway. (2000) (75)
Identification and quantitation of the lesion accompanying base release in bleomycin-mediated DNA degradation (1990) (74)
Sequence-specific isotope effects on the cleavage of DNA by bleomycin. (1989) (74)
Generation of the R2 subunit of ribonucleotide reductase by intein chemistry: insertion of 3-nitrotyrosine at residue 356 as a probe of the radical initiation process. (2003) (73)
Electron paramagnetic resonance investigations of a kinetically competent intermediate formed in ribonucleotide reduction: Evidence for a thiyl radical-cob(II)alamin interaction (1996) (72)
Analysis of Transient Polyhydroxybutyrate Production in Wautersia eutropha H16 by Quantitative Western Analysis and Transmission Electron Microscopy (2005) (72)
Escherichia coli class Ib ribonucleotide reductase contains a dimanganese(III)-tyrosyl radical cofactor in vivo. (2011) (70)
The core structure of X generated in the assembly of the diiron cluster of ribonucleotide reductase: 17O2 and H217O ENDOR (1998) (70)
Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway. (1992) (69)
Detection of a new substrate-derived radical during inactivation of ribonucleotide reductase from Escherichia coli by gemcitabine 5'-diphosphate. (1998) (67)
Sequence-specific double-strand cleavage of DNA by Fe-bleomycin. 1. The detection of sequence-specific double-strand breaks using hairpin oligonucleotides. (1995) (67)
Mechanism of Assembly of the Diferric Cluster−Tyrosyl Radical Cofactor of Escherichia coli Ribonucleotide Reductase from the Diferrous Form of the R2 Subunit (1996) (66)
Location of the redox-active thiols of ribonucleotide reductase: sequence similarity between the Escherichia coli and Lactobacillus leichmannii enzymes. (1987) (66)
Studies of Co·Bleomycin A2 Green: Its Detailed Structural Characterization by NMR and Molecular Modeling and Its Sequence-Specific Interaction with DNA Oligonucleotides (1996) (64)
Use of rapid kinetics methods to study the assembly of the diferric-tyrosyl radical cofactor of E. coli ribonucleotide reductase. (1995) (64)
Solution Structure of Co·Bleomycin A2 Green Complexed with d(CCAGGCCTGG) (1996) (64)
Kinetics of radical intermediate formation and deoxynucleotide production in 3-aminotyrosine-substituted Escherichia coli ribonucleotide reductases. (2011) (63)
Structure of the Catalytic Domain of the Class I Polyhydroxybutyrate Synthase from Cupriavidus necator* (2016) (63)
Ribonucleotide Reductases: Structure, Chemistry, and Metabolism Suggest New Therapeutic Targets. (2020) (63)
EPR Investigations of the Inactivation of E. coli Ribonucleotide Reductase with 2'-Azido-2'-deoxyuridine 5'-Diphosphate: Evidence for the Involvement of the Thiyl Radical of C225-R1 (1995) (62)
PELDOR spectroscopy with DOPA-beta2 and NH2Y-alpha2s: distance measurements between residues involved in the radical propagation pathway of E. coli ribonucleotide reductase. (2007) (62)
Growth and Localization of Polyhydroxybutyrate Granules in Ralstonia eutropha (2011) (61)
NrdI, a flavodoxin involved in maintenance of the diferric-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase (2008) (61)
Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms. (1994) (61)
Hydrogen Bond Network between Amino Acid Radical Intermediates on the Proton-Coupled Electron Transfer Pathway of E. coli α2 Ribonucleotide Reductase (2014) (61)
DNA oligonucleotides with A, T, G or C opposite an abasic site: structure and dynamics (2007) (61)
Solution structure of Co(III)-bleomycin-OOH bound to a phosphoglycolate lesion containing oligonucleotide: implications for bleomycin-induced double-strand DNA cleavage. (2001) (61)
X-ray crystal structure of aminoimidazole ribonucleotide synthetase (PurM), from the Escherichia coli purine biosynthetic pathway at 2.5 A resolution. (1999) (61)
Analogs of phosphoenolpyruvate. Substrate specificities of enolase and pyruvate kinase from rabbit muscle. (1972) (60)
Equilibration of tyrosyl radicals (Y356•, Y731•, Y730•) in the radical propagation pathway of the Escherichia coli class Ia ribonucleotide reductase. (2011) (59)
X-ray crystal structure of glycinamide ribonucleotide synthetase from Escherichia coli. (1998) (59)
Site-specific incorporation of fluorotyrosines into the R2 subunit of E. coli ribonucleotide reductase by expressed protein ligation (2007) (58)
A hot oxidant, 3-NO2Y122 radical, unmasks conformational gating in ribonucleotide reductase. (2010) (58)
Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase. (2012) (58)
Isotope effects on the cleavage of DNA by bleomycin: mechanism and modulation. (1993) (58)
Domain organization of Salmonella typhimurium formylglycinamide ribonucleotide amidotransferase revealed by X-ray crystallography. (2004) (58)
Bleomycins: new methods will allow reinvestigation of old issues. (2004) (57)
Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex (2020) (57)
Characterization and chemical properties of phosphoribosylamine, an unstable intermediate in the de novo purine biosynthetic pathway. (1988) (57)
Analogs of phosphoenolpyruvate. On the specificity of pyruvate kinase from rabbit muscle. (1971) (57)
Clofarabine 5′-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit (2011) (57)
Exafs studies of binuclear iron proteins hemerythrin and ribonucleotide reductase (1987) (57)
Three-dimensional structure of N5-carboxyaminoimidazole ribonucleotide synthetase: a member of the ATP grasp protein superfamily. (1999) (57)
Identification of the alkaline-labile product accompanying cytosine release during bleomycin-mediated degradation of d(CGCGCG) (1986) (56)
Radicals with a controlled lifestyle. (2003) (56)
Mechanistic Studies of Semicarbazone Triapine Targeting Human Ribonucleotide Reductase in Vitro and in Mammalian Cells (2012) (56)
Inactivation of ribonucleotide reductase by (E)-2'-fluoromethylene-2'-deoxycytidine 5'-diphosphate: a paradigm for nucleotide mechanism-based inhibitors. (1996) (55)
Pulsed ELDOR spectroscopy measures the distance between the two tyrosyl dadicals in the R2 subunit of the E. coli ribonucleotide reductase. (2003) (55)
Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein (2006) (54)
Structure of the yeast ribonucleotide reductase Y2Y4 heterodimer (2001) (54)
YfaE, a ferredoxin involved in diferric-tyrosyl radical maintenance in Escherichia coli ribonucleotide reductase. (2007) (54)
Binding site revealed of nature's most beautiful cofactor. (1994) (53)
Studies on the catalysis of carbon-cobalt bond homolysis by ribonucleoside triphosphate reductase: evidence for concerted carbon-cobalt bond homolysis and thiyl radical formation. (1999) (53)
A model of the structure of HOO-Co.bleomycin bound to d(CCAGTACTGG): recognition at the d(GpT) site and implications for double-stranded DNA cleavage. (1997) (53)
A non-heme iron protein with heme tendencies: an investigation of the substrate specificity of thymine hydroxylase. (1993) (53)
Formylglycinamide ribonucleotide synthetase from Escherichia coli: cloning, sequencing, overproduction, isolation, and characterization. (1989) (52)
Radicals in biological catalysis. (1988) (52)
2,3-difluorotyrosine at position 356 of ribonucleotide reductase R2: a probe of long-range proton-coupled electron transfer. (2003) (51)
Interaction of C225SR1 mutant subunit of ribonucleotide reductase with R2 and nucleoside diphosphates: tales of a suicidal enzyme. (1992) (51)
UV Endonuclease V from Bacteriophage T4 Catalyzes DNA Strand Cleavage at Aldehydic Abasic Sites by a Syn β-Elimination Reaction (1989) (51)
Mechanism of inactivation of human ribonucleotide reductase with p53R2 by gemcitabine 5'-diphosphate. (2009) (50)
Bacillus subtilis class Ib ribonucleotide reductase is a dimanganese(III)-tyrosyl radical enzyme. (2011) (50)
A multifunctional protein possessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotide transformylase, and aminoimidazole ribonucleotide synthetase activities in de novo purine biosynthesis. (1985) (50)
RAPID FREEZE-QUENCH ENDOR OF THE RADICAL X INTERMEDIATE OF ESCHERICHIA COLI RIBONUCLEOTIDE REDUCTASE USING 17O2, H217O, AND 2H2O (1996) (49)
Purification of ribonucleotide reductase subunits Y1, Y2, Y3, and Y4 from yeast: Y4 plays a key role in diiron cluster assembly. (1999) (49)
Structure of the Nucleotide Radical Formed during Reaction of CDP/TTP with the E441Q-α2β2 of E. coli Ribonucleotide Reductase (2008) (49)
Investigation of in Vivo Diferric Tyrosyl Radical Formation in Saccharomyces cerevisiae Rnr2 Protein (2011) (49)
Direct observation of a transient tyrosine radical competent for initiating turnover in a photochemical ribonucleotide reductase. (2007) (48)
High-frequency (140-GHz) time domain EPR and ENDOR spectroscopy: the tyrosyl radical-diiron cofactor in ribonucleotide reductase from yeast. (2001) (48)
The mechanism of Lactobacillus leichmannii ribonucleotide reductase. Evidence for 3' carbon-hydrogen bond cleavage and a unique role for coenzyme B12. (1986) (47)
Function of the diiron cluster of Escherichia coli class Ia ribonucleotide reductase in proton-coupled electron transfer. (2013) (47)
Transcriptional analysis of Ralstonia eutropha genes related to poly-(R)-3-hydroxybutyrate homeostasis during batch fermentation (2005) (47)
Mechanism of action of enolase: effect of the beta-hydroxy group on the rate of dissociation of the alpha-carbon-hydrogen bond. (1980) (46)
Cloning, overproduction, and purification of the B2 subunit of ribonucleoside-diphosphate reductase (1986) (46)
Interaction of Co.cntdot.Bleomycin A2 (Green) with d(CCAGGCCTGG)2: Evidence for Intercalation Using 2D NMR (1994) (46)
Identification of the source of oxygen in the alkaline-labile product accompanying cytosine release during bleomycin-mediated oxidative degradation of d(CGCGCG) (1990) (46)
New insight into the mechanism of base propenal formation during bleomycin-mediated DNA degradation (1992) (46)
ENDOR spectroscopy and DFT calculations: evidence for the hydrogen-bond network within α2 in the PCET of E. coli ribonucleotide reductase. (2012) (46)
Electron transfer reactions of fluorotyrosyl radicals. (2006) (45)
Turning on ribonucleotide reductase by light-initiated amino acid radical generation. (2004) (45)
Neocarzinostatin-induced hydrogen atom abstraction from C-4' and C-5' of the T residue at a d(GT) step in oligonucleotides: shuttling between deoxyribose attack sites based on isotope selection effects. (1991) (45)
Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway. (1999) (44)
Evidence for the direct transfer of the carboxylate of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to generate 4-carboxy-5-aminoimidazole ribonucleotide catalyzed by Escherichia coli PurE, an N5-CAIR mutase. (1999) (43)
Highly Electrophilic, Catalytically Active and Redox‐Responsive Cobaltoceniumyl and Ferrocenyl Triazolylidene Coinage Metal Complexes (2018) (43)
Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer (2015) (43)
Photo-ribonucleotide reductase β2 by selective cysteine labeling with a radical phototrigger (2011) (43)
Novel diferric radical intermediate responsible for tyrosyl radical formation in assembly of the cofactor of ribonucleotide reductase (1991) (43)
Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5'-diphosphate in the presence or absence of reductant. (2009) (43)
Isotope effects of the sequence-specific cleavage of DNA by neocarzinostatin : kinetic partitioning between 4'- and 5'-hydrogen abstraction at unique thymidine sites (1991) (43)
Thermodynamic and kinetic studies on carbon-cobalt bond homolysis by ribonucleoside triphosphate reductase: the importance of entropy in catalysis. (1999) (42)
Products of the inactivation of ribonucleoside diphosphate reductase from Escherichia coli with 2'-azido-2'-deoxyuridine 5'-diphosphate. (1987) (42)
Mechanism of inactivation of Escherichia coli and Lactobacillus leichmannii ribonucleotide reductases by 2'-chloro-2'-deoxynucleotides: evidence for generation of 2-methylene-3(2H)-furanone. (1984) (42)
Conserved electron donor complex Dre2–Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis (2014) (41)
Structures of the yeast ribonucleotide reductase Rnr2 and Rnr4 homodimers. (2004) (41)
Binding of Cob(II)alamin to the adenosylcobalamin-dependent ribonucleotide reductase from Lactobacillus leichmannii. Identification of dimethylbenzimidazole as the axial ligand. (1999) (41)
Alternative model for mechanism-based inhibition of Escherichia coli ribonucleotide reductase by 2'-azido-2'-deoxyuridine 5'-diphosphate. (1993) (41)
Photoactive peptides for light-initiated tyrosyl radical generation and transport into ribonucleotide reductase. (2007) (41)
GC/MS methods to quantify the 2-deoxypentos-4-ulose and 3'-phosphoglycolate pathways of 4' oxidation of 2-deoxyribose in DNA: application to DNA damage produced by gamma radiation and bleomycin. (2007) (41)
Purification of polyhydroxybutyrate synthase from its native organism, Ralstonia eutropha: implications for the initiation and elongation of polymer formation in vivo. (2012) (40)
Genetic Characterization and Role in Virulence of the Ribonucleotide Reductases of Streptococcus sanguinis * ♦ (2013) (40)
Structure of the nitrogen-centered radical formed during inactivation of E. coli ribonucleotide reductase by 2'-azido-2'-deoxyuridine-5'-diphosphate: trapping of the 3'-ketonucleotide. (2005) (40)
Clofarabine targets the large subunit (α) of human ribonucleotide reductase in live cells by assembly into persistent hexamers. (2012) (40)
Unmasking the chemistry of DNA cleavage by the esperamicins : modulation of 4'-hydrogen abstraction and bistranded damage by the fucose-anthranilate moiety (1992) (39)
Choosing the Right Metal: Case Studies of Class I Ribonucleotide Reductases* (2014) (39)
Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase (2013) (38)
Deciphering radical transport in the large subunit of class I ribonucleotide reductase. (2011) (38)
Current ideas on the chemical mechanism of ribonucleotide reductases. (1985) (37)
The active form of the Saccharomyces cerevisiae ribonucleotide reductase small subunit is a heterodimer in vitro and in vivo. (2005) (36)
Streptococcus sanguinis Class Ib Ribonucleotide Reductase (2013) (36)
Importance of the Maintenance Pathway in the Regulation of the Activity of Escherichia coli Ribonucleotide Reductase† (2008) (36)
In vitro analysis of the chain termination reaction in the synthesis of poly-(R)-beta-hydroxybutyrate by the class III synthase from Allochromatium vinosum. (2005) (35)
High-frequency 180 GHz PELDOR (2005) (35)
5.08 – Mechanistic Investigations of Ribonucleotide Reductases (1999) (35)
Why multiple small subunits (Y2 and Y4) for yeast ribonucleotide reductase? Toward understanding the role of Y4 (2001) (35)
Biophysical Characterization of Fluorotyrosine Probes Site-Specifically Incorporated into Enzymes: E. coli Ribonucleotide Reductase As an Example (2016) (34)
Detection of intermediates from the polymerization reaction catalyzed by a D302A mutant of class III polyhydroxyalkanoate (PHA) synthase. (2005) (33)
Forward and reverse electron transfer with the Y356DOPA-beta2 heterodimer of E. coli ribonucleotide reductase. (2007) (33)
Identification of protonated oxygenic ligands of ribonucleotide reductase intermediate X. (2009) (33)
Mechanism of bleomycin: evidence for 4'-ketone formation in poly(dA-dU) associated exclusively with free base release. (1985) (33)
Purification and characterization of aminoimidazole ribonucleotide synthetase from Escherichia coli. (1986) (33)
Characterization of a substrate-derived radical detected during the inactivation of ribonucleotide reductase from Escherichia coli by 2'- fluoromethylene-2'-deoxycytidine 5'-diphosphate (1998) (33)
The function of adenosylcobalamin in the mechanism of ribonucleoside triphosphate reductase from Lactobacillus leichmannii. (1998) (32)
Class III polyhydroxybutyrate synthase: involvement in chain termination and reinitiation. (2005) (32)
NMR STUDIES OF CO.DEGLYCOBLEOMYCIN A2 GREEN AND ITS COMPLEX WITH D(CCAGGCCTGG) (1998) (32)
Characterization of Y122F R2 of Escherichia coli ribonucleotide reductase by time-resolved physical biochemical methods and X-ray crystallography. (1998) (32)
Kinetics of Hydrogen Atom Abstraction from Substrate by an Active Site Thiyl Radical in Ribonucleotide Reductase (2014) (31)
pH Dependence of charge transfer between tryptophan and tyrosine in dipeptides. (2005) (31)
Solution structure of an oligonucleotide containing an abasic site: evidence for an unusual deoxyribose conformation. (2001) (31)
Accurate and rapid modeling of iron-bleomycin-induced DNA damage using tethered duplex oligonucleotides and electrospray ionization ion trap mass spectrometric analysis. (2000) (31)
Glycinamide ribonucleotide synthetase from Escherichia coli: cloning, overproduction, sequencing, isolation, and characterization. (1990) (31)
Conformationally Dynamic Radical Transfer within Ribonucleotide Reductase. (2017) (31)
Mechanism of inactivation of Escherichia coli ribonucleotide reductase by 2'-chloro-2'-deoxyuridine 5'-diphosphate: evidence for generation of a 2'-deoxy-3'-ketonucleotide via a net 1,2 hydrogen shift. (1985) (31)
Substrate specificity of formylglycinamidine synthetase. (1986) (30)
Site-specific replacement of a conserved tyrosine in ribonucleotide reductase with an aniline amino acid: a mechanistic probe for a redox-active tyrosine. (2004) (30)
Formal Reduction Potentials of Difluorotyrosine and Trifluorotyrosine Protein Residues: Defining the Thermodynamics of Multistep Radical Transfer. (2017) (30)
Isotope effects on the sequence-specific cleavage of dC in d(AGC) sequences by neocarzinostatin: elucidation of chemistry of minor lesions (1990) (30)
A Systematic Evaluation of the Bleomycin A2 l-Threonine Side Chain: Its Role in Preorganization of a Compact Conformation Implicated in Sequence-Selective DNA Cleavage (1998) (29)
DEFINITION OF THE EFFECT AND ROLE OF THE BLEOMYCIN A2 VALERATE SUBSTITUENTS : PREORGANIZATION OF A RIGID, COMPACT CONFORMATION IMPLICATED IN SEQUENCE- SELECTIVE DNA CLEAVAGE (1998) (29)
Structural Examination of the Transient 3-Aminotyrosyl Radical on the PCET Pathway of E. coli Ribonucleotide Reductase by Multifrequency EPR Spectroscopy (2009) (29)
STRUCTURAL CHARACTERIZATION OF CO.BLEOMYCIN A2 BROWN : FREE AND BOUND TO D(CCAGGCCTGG) (1997) (29)
The formylglycinamide ribonucleotide amidotransferase complex from Bacillus subtilis: metabolite-mediated complex formation. (2004) (29)
Self‐management of oral anticoagulation: long‐term results (2003) (29)
DNA degradation by bleomycin: evidence for 2'R-proton abstraction and for C-O bond cleavage accompanying base propenal formation. (1986) (28)
Inorganic pyrophosphate is released from 2'-chloro-2'-deoxyuridine 5'-diphosphate by ribonucleoside diphosphate reductase (1980) (28)
Redox-linked structural changes in ribonucleotide reductase. (2009) (28)
Protein Radicals in Enzyme Catalysis. [Chem. Rev. 1998, 98, 705minus sign762. (1998) (28)
Complexed structures of formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima describe a novel ATP binding protein superfamily. (2006) (27)
Circular Dichroism and Magnetic Circular Dichroism Studies of the Fully Reduced Binuclear Non-Heme Iron Active Site in the Escherichia coli R2 Subunit of Ribonucleoside Diphosphate Reductase (1995) (27)
Mechanism-based inhibition of a mutant Escherichia coli ribonucleotide reductase (cysteine-225----serine) by its substrate CDP. (1989) (27)
The dimanganese(II) site of Bacillus subtilis class Ib ribonucleotide reductase. (2012) (27)
Charge-Transfer Dynamics at the α/β Subunit Interface of a Photochemical Ribonucleotide Reductase. (2016) (26)
Are carboxylations involving biotin concerted or nonconcerted? (1980) (26)
Formal reduction potential of 3,5-difluorotyrosine in a structured protein: insight into multistep radical transfer. (2013) (26)
Fluoride, pyrophosphate, and base release from 2'-deoxy-2'-fluoronucleoside 5'-diphosphates by ribonucleoside-diphosphate reductase. (1980) (26)
Use of 3-aminotyrosine to examine the pathway dependence of radical propagation in Escherichia coli ribonucleotide reductase. (2009) (25)
Redox-linked changes to the hydrogen-bonding network of ribonucleotide reductase β2. (2013) (25)
A model for the Bacillus subtilis formylglycinamide ribonucleotide amidotransferase multiprotein complex. (2004) (25)
Identification of two alpha-ketoglutarate-dependent dioxygenases in extracts of Rhodotorula glutinis catalyzing deoxyuridine hydroxylation. (1985) (25)
Alimentary Bleeding of Obscure Origin (1959) (25)
A Chemically Competent Thiosulfuranyl Radical on the Escherichia coli Class III Ribonucleotide Reductase (2014) (25)
Two Episodes of Cardiac Arrest in One Week (1960) (25)
N5-CAIR mutase: role of a CO2 binding site and substrate movement in catalysis. (2007) (24)
Gemcitabine 5'-triphosphate is a stoichiometric mechanism-based inhibitor of Lactobacillus leichmannii ribonucleoside triphosphate reductase: evidence for thiyl radical-mediated nucleotide radical formation. (1998) (24)
Polyhydroxyalkanoate (PHA) hemeostasis: the role of PHA synthase. (2003) (24)
Synthesis and characterization of oligonucleotides containing a 4'-keto abasic site. (2004) (24)
A >200 meV Uphill Thermodynamic Landscape for Radical Transport in Escherichia coli Ribonucleotide Reductase Determined Using Fluorotyrosine-Substituted Enzymes (2016) (24)
Class II Ribonucleotide Reductases Catalyze Carbon−Cobalt Bond Reformation on Every Turnover (1999) (23)
Mechanism-based inactivation of thymine hydroxylase, an alpha-ketoglutarate-dependent dioxygenase, by 5-ethynyluracil. (1993) (23)
3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound (2018) (23)
Spectroscopic Evidence for a H Bond Network at Y356 Located at the Subunit Interface of Active E. coli Ribonucleotide Reductase. (2017) (23)
Convergent allostery in ribonucleotide reductase (2018) (23)
Isolation of a multifunctional protein with aminoimidazole ribonucleotide synthetase, glycinamide ribonucleotide synthetase, and glycinamide ribonucleotide transformylase activities: characterization of aminoimidazole ribonucleotide synthetase. (1986) (23)
Radical transfer in E. coli ribonucleotide reductase: a NH2Y731/R411A-α mutant unmasks a new conformation of the pathway residue 731† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03460d (2015) (22)
Nuclear magnetic resonance structural studies and molecular modeling of duplex DNA containing normal and 4'-oxidized abasic sites. (2007) (22)
Control of metallation and active cofactor assembly in the class Ia and Ib ribonucleotide reductases: diiron or dimanganese? (2011) (22)
Effect of substrate on the diiron(III) site in stearoyl acyl carrier protein delta 9-desaturase as disclosed by cryoreduction electron paramagnetic resonance/electron nuclear double resonance spectroscopy. (2005) (22)
Investigation of the ATP binding site of Escherichia coli aminoimidazole ribonucleotide synthetase using affinity labeling and site-directed mutagenesis. (1999) (21)
The class III ribonucleotide reductase from Neisseria bacilliformis can utilize thioredoxin as a reductant (2014) (20)
The risk of gastric cancer after medical treatment for gastric ulcer. (1957) (20)
Degradation of DNA-RNA hybrids by bleomycin: evidence for DNA strand specificity and for possible structural modulation of chemical mechanism (1988) (20)
Formylglycinamide Ribonucleotide Amidotransferase from Thermotoga maritima: Structural Insights into Complex Formation†‡ (2008) (20)
Solution structure of the hydroperoxide of Co(III) phleomycin complexed with d(CCAGGCCTGG)2: evidence for binding by partial intercalation. (2002) (20)
Controlling radical reactions (1994) (20)
EXAFS Studies of the B2 Subunit of the Ribonucleotide Reductase from E. coli (1986) (19)
Non-Kramers ESEEM of integer-spin diferrous carboxylate-bridged clusters in proteins (1997) (19)
Bleomycins: A Structural Model for Specificity, Binding, and Double Strand Cleavage (2010) (19)
Determination of the in vivo stoichiometry of tyrosyl radical per ββ' in Saccharomyces cerevisiae ribonucleotide reductase (2006) (19)
Detection of covalent and noncovalent intermediates in the polymerization reaction catalyzed by a C149S class III polyhydroxybutyrate synthase. (2009) (19)
On the mechanism of ribonucleoside triphosphate reductase from Lactobacillus leichmannii. Evidence for 3' C--H bond cleavage. (1981) (19)
Reverse Electron Transfer Completes the Catalytic Cycle in a 2,3,5-Trifluorotyrosine-Substituted Ribonucleotide Reductase (2015) (18)
2'-Azido-2'-deoxynucleotide interaction with E. coli ribonucleotide reductase: generation of a new radical species (1984) (18)
Glutamate 350 Plays an Essential Role in Conformational Gating of Long-Range Radical Transport in Escherichia coli Class Ia Ribonucleotide Reductase. (2017) (18)
Conformational Motions and Water Networks at the α/β Interface in E. coli Ribonucleotide Reductase. (2020) (18)
The diferric-tyrosyl radical cluster of ribonucleotide reductase and cytosolic iron-sulfur clusters have distinct and similar biogenesis requirements (2017) (17)
Glutamate 52-β at the α/β subunit interface of Escherichia coli class Ia ribonucleotide reductase is essential for conformational gating of radical transfer (2017) (17)
Assessment of the Role of the Bleomycin A2 Pyrimidoblamic Acid C4 Amino Group (1998) (17)
Composition and Structure of the Inorganic Core of Relaxed Intermediate X(Y122F) of Escherichia coli Ribonucleotide Reductase. (2015) (17)
Epimerization at carbon-5' of (5'R)-[5'-2H]adenosylcobalamin by ribonucleoside triphosphate reductase: cysteine 408-independent cleavage of the Co-C5' bond. (2003) (17)
Bleomycin mediated degradation of DNA-RNA hybrids does not involve C-1' chemistry. (1992) (17)
Incorporation of 18O into glycolic acid obtained from the bleomycin-mediated degradation of DNA. Evidence for 4'-radical trapping by 18O2 (1987) (17)
Methodology to probe subunit interactions in ribonucleotide reductases. (2008) (17)
Biotin carboxylations--concerted or not concerted? That is the question! (1977) (16)
Identification of an active site residue of the R1 subunit of ribonucleotide reductase from Escherichia coli: characterization of substrate-induced polypeptide cleavage by C225SR1. (1996) (16)
Chemistry with an Artificial Primer of Polyhydroxybutyrate Synthase Suggests a Mechanism for Chain Termination (2015) (15)
Bacillus subtilis Class Ib Ribonucleotide Reductase: High Activity and Dynamic Subunit Interactions (2014) (15)
A Ferredoxin Disulfide Reductase Delivers Electrons to the Methanosarcina barkeri Class III Ribonucleotide Reductase (2015) (14)
High-frequency EPR and ENDOR: Time-domain spectroscopy of ribonucleotide reductase (2001) (14)
Effects in 94 GHz Orientation-Selected PELDOR on a Rigid Pair of Radicals with Non-Collinear Axes (2009) (14)
An endogenous dAMP ligand in Bacillus subtilis class Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP (2018) (14)
2'-Deoxy-2'-halonucleotides as alternate substrates and mechanism-based inactivators of Lactobacillus leichmannii ribonucleotide reductase. (1987) (14)
Interaction of 3'-[3H]2'-Chloro-2'-deoxyuridine 5'-triphosphate with ribonucleotide reductase from Lactobacillus leichmannii. (1983) (14)
Modulation of Y356 photooxidation in E. coli class Ia ribonucleotide reductase by Y731 across the α2:β2 interface. (2013) (13)
Detection of Water Molecules on the Radical Transfer Pathway of Ribonucleotide Reductase by 17O Electron–Nuclear Double Resonance Spectroscopy (2021) (13)
DIRECT EPR SPECTROSCOPIC EVIDENCE FOR AN ALLYLIC RADICAL GENERATED FROM (E)-2'-FLUOROMETHYLENE-2'-DEOXYCYTIDINE 5'-DIPHOSPHATE BY E. COLI RIBONUCLEOTI DE REDUCTASE (1998) (13)
Alimentary bleeding of obscure origin; a follow-up study and commentary. (1959) (13)
Phenomenology of Hydrogen Flaking in Nuclear Reactor Pressure Vessels* (2014) (13)
Mechanism of ribonucleoside diphosphate reductase from Escherichia coli. Evidence for 3'-C--H bond cleavage. (1983) (13)
Re(bpy)(CO)3CN as a probe of conformational flexibility in a photochemical ribonucleotide reductase. (2009) (13)
Photochemical Generation of a Tryptophan Radical within the Subunit Interface of Ribonucleotide Reductase. (2016) (13)
Inactivation of the Lactobacillus leichmannii ribonucleoside triphosphate reductase by 2'-chloro-2'-deoxyuridine 5'-triphosphate: stoichiometry of inactivation, site of inactivation, and mechanism of the protein chromophore formation. (1988) (12)
Long-Term Results of Patients' Self-Management of Oral Anticoagulation (2003) (12)
Replacement of Y730 and Y731 in the alpha2 subunit of Escherichia coli ribonucleotide reductase with 3-aminotyrosine using an evolved suppressor tRNA/tRNA-synthetase pair. (2009) (12)
Mechanism-based inhibition of thymine hydroxylase (1989) (12)
Generation of a Tryptophan Radical in High Quantum Yield from a Novel Amino Acid Analog Using Near-UV/Visible Light (1997) (12)
Cu(II) complexes with hydrazone-functionalized phenanthrolines as self-activating metallonucleases (2017) (12)
Mechanism of ribonucleotide reductase from herpes simplex virus type 1. Evidence for 3' carbon-hydrogen bond cleavage and inactivation by nucleotide analogs. (1986) (11)
Characterization of a Novel, Stable Norcaradiene Adduct Resulting from the Inactivation of Thymine Hydroxylase by 5-Ethynyluracil (1995) (11)
Photochemical Rescue of a Conformationally Inactivated Ribonucleotide Reductase. (2018) (11)
Use of 2,3,5-F(3)Y-β2 and 3-NH(2)Y-α2 to study proton-coupled electron transfer in Escherichia coli ribonucleotide reductase. (2011) (11)
Selenocysteine Substitution into a Class I Ribonucleotide Reductase. (2019) (11)
The Two Faces of SAM (2011) (10)
Properties of Site-Specifically Incorporated 3-Aminotyrosine in Proteins To Study Redox-Active Tyrosines: Escherichia coli Ribonucleotide Reductase as a Paradigm. (2018) (10)
Mechanistic Insight with HBCH2CoA as a Probe to Polyhydroxybutyrate (PHB) Synthases (2014) (10)
Inactivation of Lactobacillus leichmannii ribonucleotide reductase by 2',2'-difluoro-2'-deoxycytidine 5'-triphosphate: covalent modification. (2010) (9)
Modulation of Phenol Oxidation in Cofacial Dyads. (2015) (9)
Direct interfacial Y731 oxidation in α2 by a photoβ2 subunit of E. coli class Ia ribonucleotide reductase (2015) (9)
Ribonucleotide reductases: radical enzymes with suicidal tendencies. (1993) (9)
Mechanism of B12-dependent ribonucleotide reductase (2004) (9)
Gated Proton Release during Radical Transfer at the Subunit Interface of Ribonucleotide Reductase. (2020) (9)
Dinuclear non-heme iron centers: structure and function (1991) (8)
Determination of the in vivo stoichiometry of tyrosyl radical per betabeta' in Saccharomyces cerevisiae ribonucleotide reductase. (2006) (8)
Investigation of in Vivo Roles of the C-terminal Tails of the Small Subunit (ββ′) of Saccharomyces cerevisiae Ribonucleotide Reductase (2013) (8)
CAAC‐Based Thiele and Schlenk Hydrocarbons (2020) (8)
Subunit Interaction Dynamics of Class Ia Ribonucleotide Reductases: In Search of a Robust Assay. (2020) (7)
Chemical characterization of phosphoribosylamine, a substrate for newly discovered trifunctional protein containing glycineamide ribonucleotide synthetase activity. (1987) (7)
Chemical specificity of pyruvate kinase from yeast. (1975) (6)
N,N′‐Ethylene‐Bridged Bis‐2‐Aryl‐Pyrrolinium Cations to E‐Diaminoalkenes: Non‐Identical Stepwise Reversible Double‐Redox Coupled Bond Activation Reactions (2020) (6)
Acyl migration in the production of thymine. Propenal from 3'-O-benzoyl-5'-deoxy-4'-(hydroperoxy)thymidine: a reinterpretation of a putative model for bleomycin-mediated DNA degradation (1991) (6)
Radicals in Biology: Your Life Is in Their Hands. (2021) (6)
Inactivation of Lactobacillus leichmannii ribonucleotide reductase by 2',2'-difluoro-2'-deoxycytidine 5'-triphosphate: adenosylcobalamin destruction and formation of a nucleotide-based radical. (2010) (6)
Discovery of a New Class I Ribonucleotide Reductase with an Essential DOPA Radical and NO Metal as an Initiator of Long-Range Radical Transfer. (2018) (6)
Mechanistic analyses of site-specific degradation in DNA-RNA hybrids by prototypic DNA cleavers. (1997) (6)
Mapping the subunit interface of ribonucleotide reductase (RNR) using photo cross-linking. (2008) (6)
Inactivation of the ribonucleoside triphosphate reductase from Lactobacillus leichmannii by 2'-chloro-2'-deoxyuridine 5'-triphosphate: a 3'-2' hydrogen transfer during the formation of 3'-keto-2'-deoxyuridine 5'-triphosphate. (1988) (5)
PET Polymer Recycling. (2020) (5)
Ribonucleotide reductases. (1990) (5)
Statistical analysis of ENDOR spectra (2021) (5)
p- and m-Phenylene Bridged Carbon Centred Diradicals with CAAC-Scaffolds: Analogues of Thiele and Schlenk Hydrocarbons. (2020) (5)
The transformations of a methylene-bridged bis-triazolium salt: a mesoionic carbene based metallocage and analogues of TCNE and NacNac†‡ (2021) (5)
Evidence for Electron Transfer between Graphene and Non‐Covalently Bound π‐Systems (2020) (5)
Isomerization Reactions in Anionic Mesoionic Carbene‐Borates and Control of Properties and Reactivities in the Resulting CoII Complexes through Agostic Interactions (2020) (5)
Synthesis, characterization and solution structure of tethered oligonucleotides containing an internal 3'-phosphoglycolate, 5'-phosphate gapped lesion. (2002) (5)
A Systematic Evaluation of the Bleomycin A2 L‐Threonine Side Chain: Its Role in Preorganization of a Compact Conformation Implicated in Sequence‐Selective DNA Cleavage. (1999) (5)
Mechanistic Studies of Bleomycin-Mediated DNA Cleavage Using Isotope Labeling (1988) (5)
Chris Raetz, scientist and enduring friend (2011) (5)
Christian Raetz: scientist and friend extraordinaire. (2013) (5)
Qualification of remedial methods to prevent primary-side stress corrosion cracking of steam generator tubing: Volume 3, Global heat treatment: Final report (1987) (5)
Design of a Fluoro-olefin Cytidine Nucleoside as a Bioprecursor of a Mechanism-Based Inhibitor of Ribonucleotide Reductase (1996) (4)
Computational biochemistry: Models of transition (2007) (4)
Assembly of the iron center-tyrosyl radical cofactor of ribonucleotide reductase (1993) (4)
Excited state spectral features of the radical reduced, native and fully reduced forms of the coupled binuclear non-heme iron center in ribonucleotide reductase : active site differences relative to hemerythrin (1991) (4)
Effects of hypoxanthine substitution on bleomycin-mediated DNA strand degradation in DNA-RNA hybrids. (1997) (4)
A Palladium-Free Sonogashira Coupling Protocol Employing an In Situ Prepared Copper/Chelating 1,2,3-Triazolylidene System (2020) (4)
Inactivation of Lactobacillus leichmannii ribonucleotide reductase by F2CTP: covalent modification (2010) (4)
Ribonucleotide reductase, a novel drug target for gonorrhea (2022) (4)
Unnatural amino acids: better than the real things? (2009) (4)
Ribonucleotide Reductase: Recent Advances (2008) (4)
Enolase catalyzed beta,gamma-alpha,beta isomerization of 2-phospho-3-butenoic acid to (Z)-phosphoenol-alpha-ketobutyrate. (1975) (4)
Nanosecond generation of tyrosyl radicals via laser-initiated decaging of oxalate-modified amino acids. (2002) (3)
Equilibration of Tyrosyl Radicals (Y[• over 356], Y[• over 731], Y[• over 730]) in the Radical Propagation Pathway of the Escherichia coli Class Ia Ribonucleotide Reductase (2011) (3)
NONTEMPLATE-DEPENDENT POLYMERIZATION (2005) (3)
Inactivation of Lactobacillus leichmannii ribonucleotide reductase by F2CTP: adenosylcobalamin destruction and formation of a nucleotide based radical (2010) (3)
Definition of the Effect and Role of the Bleomycin A2 Valerate Substituents: Preorganization of a Rigid, Compact Conformation Implicated in Sequence-Selective DNA Cleavage. (1999) (3)
19F Electron-Nuclear Double Resonance Reveals Interaction between Redox-Active Tyrosines across the α/β Interface of E. coli Ribonucleotide Reductase (2022) (3)
Ribonucleotide Reductase: Recent Advances (2008) (3)
Radical Transfer in E. Coli Ribonucleotide Reductase: a NH₂Y₇₃₁/R₄₁₁A-α Mutant Unmasks a New Conformation of the Pathway Residue 731 (2015) (3)
ASPIRATION BIOPSY OF THE KIDNEY IN SYSTEMIC LUPUS ERYTHEMATOSUS (1957) (3)
Binding of Cob(II)alamin to the Adenosylcobalamin-dependent Ribonucleotide Reductase fromLactobacillus leichmannii (1999) (3)
Vibrational Relaxation Dynamics of an Azido-Cobalt(II) Complex from Femtosecond UV-Pump/MIR-Probe Spectroscopy and Model Simulations with Ab Initio Anharmonic Couplings. (2020) (3)
One of Nature's Macromolecular Machines Demystified (1996) (3)
Mechanism based inactivation of the adenosylcobalamin-dependent ribonucleotide reductase from L. leichmannii by 2′-ara-2′-azido-2′-deoxy adenosine-5′-triphosphate: Observation of paramagnetic intermediates (1997) (3)
Adenosylcobalamin-Dependent Ribonucleotide Reductases: Still Amazing but No Longer Confusing (2007) (3)
Basis of dATP inhibition of RNRs (2018) (2)
Characterization of the secondary side deposits of pulled steam generator tubes (1995) (2)
How to simulate acid corrosion of Alloy 600 steam generator tubes (1995) (2)
Radical transfer in E. coli ribonucleotide reductase: a NH 2 Y 731 /R 411 A- a mutant unmasks a new conformation of the pathway residue 731 † (2015) (2)
Lactobacillus leichmannii and Escherichia coli ribonucleotide reductases: chemical and structural similarities. (1987) (2)
Ribonucleotide reductase, a novel target for gonorrhea (2020) (2)
Mechanism of Assembly of the Dimanganese-Tyrosyl Radical Cofactor of Class Ib Ribonucleotide Reductase : Enzymatic Generation of Superoxide Is Required for Citation (2013) (2)
Transmission Electron Microscopy Quantitative Western Analysis and H 16 by Wautersia eutropha Production in Analysis of Transient Polyhydroxybutyrate (2005) (2)
Root Cause Analysis and Characterisation of the Doel 3 and Tihange 2 Reactor Pressure Vessel Flaws (2016) (2)
Stress Corrosion Cracking of Alloys 690, 800 and 600 in Acid Environments Containing Copper Oxides (1996) (2)
Modulation of Y [subscript 356] Photooxidation in E. Coli Class Ia Ribonucleotide Reductase by Y [subscript 731] Across the α [subscript 2] :β [subscript 2] Interface (2013) (1)
Abstracts, division of biological chemistry, 199th national meeting of the American chemical society, April 22-27, 1990 (1989) (1)
Ribonucleotide reductases: radical enzymes with suicidal tendencies. (1995) (1)
Site-Specific Incorporation of 3-Nitrotyrosine as a Probe of pK[subscript a] Perturbation of Redox-Active Tyrosines in Ribonucleotide Reductase (2010) (1)
Protein structure. Controlling radical reactions. (1994) (1)
p‐ and m‐Phenylene Bridged Carbon Centred Diradicals with CAAC‐Scaffolds: Analogues of Thiele and Schlenk Hydrocarbons (2020) (1)
A >200 meV Uphill Thermodynamic Landscape for Radical Transport in Escherichia coli Ribonucleotide Reductase Determined Using Fluorotyrosine-Substituted Enzymes. (2016) (1)
Degradation of DNA by iron-bleomycin: mechanistic implications of product /sup 18/O incorporation (1987) (1)
Stucture of S. typhimurium formylglycinamide ribonucleotide amidotransferase (2005) (1)
Christian R. Raetz (1946–2011) (2012) (1)
Gastric mucoprotein and intrinsic factor; response of pernicious anaemia to oral vitamin B12 plus normal gastric juice treated with receptor-destroying enzyme. (1953) (1)
Qualification of remedial methods to prevent primary-side stress corrosion cracking of steam generator tubing: Volume 2, Rotopeening: Final report (1987) (1)
Mechanistic Insight with HBCH[subscript 2]CoA as a Probe to Polyhydroxybutyrate (PHB) Synthases (2014) (1)
Gastric secretion following resection of the antrum and proximal duodenum. (1957) (1)
Structure-function correlations over coupled binuclear non-heme iron enzymes (1993) (1)
Primary water stress corrosion cracking prevention by peening techniques (1986) (0)
Ribonucleotide reductase Y730NO2Y and C439A modified R1 subunit of E. coli (2010) (0)
Ribonucleotide reductase Y2Y4 heterodimer (2001) (0)
Binuclear Manganese(III) Complexes of Potential Biological Significance. (1987) (0)
Inactivation of B/sub 12/-dependent ribonucleotide reductase by 2'-azido-2'-deoxyarabinofuranosyladenine 5'-triphosphate (1986) (0)
NMR Structrure of d(CCAAAGXACTGGG), X is a 3'-phosphoglycolate, 5'-phosphate gapped lesion, 10 structures (2003) (0)
Preface and Dedicationto Christian R.H. Raetz (2012) (0)
Mapping allosteric transitions of an enzyme with SAXS, cryo-EM and crystallography (2019) (0)
Active Co-Factors of the Class I RNRs (2010) (0)
A Mössbauer investigation of the kinetic intermediates involved in formation of the tyrosyl radical-diferric center cofactor in E. Coli ribonucleotide reductase (1993) (0)
Crystal structure of class II ribonucleotide reductase: how an allosterically regulated monomer mimics a dimer (2002) (0)
NMR structure of 13mer duplex DNA containing an abasic site, averaged structure (alpha anomer) (2007) (0)
STRUCTURE OF N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE (1999) (0)
Use of 2,3,5-F[subscript 3]Y-beta 2 and 3-NH[subscript 2]Y-alpha 2 To Study Proton-Coupled Electron Transfer in Escherichia coli Ribonucleotide Reductase (2010) (0)
Bleomycin: Mechanism of action and probe of DNA conformation (1989) (0)
Mechanism of light-induced DNA strand scission by RH(phen)2PHI3+: Cleavage mediated by C3′-H abstraction (1991) (0)
Guiding and measuring electron transfers in biomolecules: Lessons for photovoltaics, materials, and medicine (2011) (0)
NMR STRUCTURE OF AN OLIGONUCLEOTIDE CONTAINING AN ABASIC SITE: ALPHA ANOMER (2001) (0)
NMR structure of d(CCAAAGXACTGGG), X is a 3'phosphoglycolate, 5'phosphate gapped lesion (2003) (0)
NMR Structure of duplex DNA d(CCAAGGXCTTGGG), X is a 3' phosphoglycolate, 5'phosphate gapped lesion (2003) (0)
CRYSTAL STRUCTURE OF B-12 DEPENDENT (CLASS II) RIBONUCLEOTIDE REDUCTASE (2002) (0)
Ribonucleotide Reductase Dimanganese(II)-NrdF from Escherichia coli (2010) (0)
Interaction of (3'-/sup 3/H)ClUTP with ribonucleotide reductase (RTPR): evidence for an enzyme catalyzed net 1,2 H-shift to produce (2'-/sup 3/H)3'-keta dUTP (1986) (0)
13mer duplex DNA containing an abasic site with beta anomer (2007) (0)
Convergent allostery in ribonucleotide reductase (2019) (0)
Structure of the Ribonucleotide Reductase Rnr4 Homodimer from Saccharomyces cerevisiae (2004) (0)
Glycinamide ribonucleotide synthetase from Escherichia coli: cloning, overproduction, sequencing, isolation, and characterization [Erratum to document cited in CA112(5):31307r] (1990) (0)
Radical Transport Facilitated by a Proton Transfer Network at the Subunit Interface of Ribonucleotide Reductase. (2023) (0)
Crystal structure of Bacillus subtilis dimanganese(II) NrdF (2012) (0)
X-ray crystal structure of E. coli apo NrdF (2013) (0)
Robert H. Abeles (1926–2000) (2001) (0)
Mechanism Based Inactivation of the Adenosylcobalamin-Dependent Ribonucleotide Reductase from L. leichmannii by 2′-Ara-2′-azido-2′- deoxy Adenosine-5′-triphosphate: Observation of Paramagnetic Intermediates. (1997) (0)
GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE (GAR-SYN) FROM E. COLI. (1998) (0)
Synthase inAlcaligenes eutrophus H16:Localization ofthe Synthase EnzymeattheSurface ofPHB Granules (1993) (0)
Radicals: Your life is in their hands (2013) (0)
13mer duplex DNA containg an abasic site with beta anomer, averaged structure (2007) (0)
Structure of B. Subtilis PurS C2 Crystal Form (2004) (0)
Structure Determination by Combination of CW and Pulsed '2-D' Orientation-Selective 1,2H Q-Band Electron-Nuclear Double Resonance: Identification of the Protonated Oxygenic Ligands of Ribonucleotide Reductase Intermediate X (1998) (0)
NMR Structure of 13mer Duplex DNA containing an abasic site (Y) in 5'-CCAAAGYACCGGG-3' (10 structures, alpha anomer) (2007) (0)
Note from the SBIC President (2016) (0)
Ribonucleotide Reductase Dimanganese(II)-NrdF from Escherichia coli in Complex with Reduced NrdI (2010) (0)
CRYSTAL STRUCTURE OF E. COLI PURE-MONONUCLEOTIDE COMPLEX. (1999) (0)
Mechanistic analysis of dna fragmentation by bleomycin (1984) (0)
CO(III)-BLEOMYCIN-OOH BOUND TO AN OLIGONUCLEOTIDE CONTAINING A PHOSPHOGLYCOLATE LESION (2001) (0)
BIOLOGICAL CATALYSIS: UNDERSTANDING RATE ACCELERATIONS IN ENZYMATIC REACTIONS (2018) (0)
Conformational aspects of dna degradation by bleomycin (1989) (0)
Structure of the complex of PurE with NitroAIR (2006) (0)
Re(bpy)(CO)[subscript 3]CN as a Probe of Conformational Flexibility in a Photochemical Ribonucleotide Reductase (2009) (0)
N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE FROM E. COLI (1999) (0)
Probing Conformational Change During Radical Propagation in the E.coli Class 1a RNR Using 3‐aminotyrosine as a Radical “Sink” (2015) (0)
Holocomplex of E. coli class Ia ribonucleotide reductase with GDP and TTP (2020) (0)
Ribonucleotide reductase Y731NO2Y modified R1 subunit of E. coli to 2. 1 A resolution (2010) (0)
A novel form of allosteric regulation in Bacillus subtilis ribonucleotide reductase revealed by SAXS and cryo-electron microscopy (2018) (0)
Ribonucleotide Synthetase Mutants Defective in Aminoimidazole Serovar Typhimurium Salmonella enterica Altered Pathway Routing in a Class of (2014) (0)
Structure of Formylglycinamide synthetase (2004) (0)
Insight into the Mechanism of Inactivation of Ribonucleotide Reductase by Gemcitabine 5#-Diphosphate in the Presence or Absence of Reductant into (2010) (0)
Past, Present, and Future Triumphs of Biochemistry (2011) (0)
Synthesis of Polyhydroxybutyrate in Promoting Ralstonia eutropha Phasin of New Insight into the Role of the PhaP (2001) (0)
and Grant J . eutropha Polyhydroxybutyrate Granules in Ralstonia Growth and Localization of (2012) (0)
Announcement: The Role of Ligands in Metallobiochemistry ACS National Symposium (1994) (0)
Inactivation of Ribonucleotide Reductase by gemcitabine‐5′‐diphosphate (2008) (0)
Ribonucleotide reductase Y122NO2Y modified R2 subunit of E. coli (2010) (0)
13mer Duplex DNA containing a 4'-oxidized abasic site, averaged structure (2007) (0)
Redox-Linked Structural Changes in Ribonucleotide Reductase Citation Offenbacher (2010) (0)
5.08J / 7.08J Biological Chemistry II, Spring 2004 (2004) (0)
Direct interfacial Y[subscript 731] oxidation in α[subscript 2] by a photoβ[subscript 2] subunit of E. coli class Ia ribonucleotide reductase (2015) (0)
Catalysis and regulation Channels, terpenes and phosphates (1998) (0)
Polyhydroxybutyrate (PHB) Synthases (PhaC): Toward understanding elongation granule formation and chain termination. (2006) (0)
Radical Propagation in E. coli Class Ia Ribonucleotide Reductase Initiated by a 2,3,5‐trifluorotyrosyl Radical Cofactor (2015) (0)
CONTROLLED RADICAL REACTIONS IN BIOLOGY AND THE IMPORTANCE OF METALLO-COFACTOR BIOSYNTHESIS (2014) (0)
Use of 2,3,5-F 3 Y- β 2 and 3-NH 2 Y- α 2 to study PCET in E. coli Ribonucleotide Reductase (2011) (0)
Polyhydroxybutyrate biosynthesis in recombinant Escherichia coli: molecular weight control via in vivo synthase activity modulation (1996) (0)
Duplex DNA containing an abasic site with an opposite G (alpha anomer) in 5'-G_AC-3' (10 structure ensemble and averaged structure) (2007) (0)
An endogenous dAMP ligand in (2018) (0)
Ribonucleotide reductase Y730NO2Y modified R1 subunit of E. coli (2010) (0)
Structure ensembles of duplex DNA containing a 4'-oxidized abasic site. (2007) (0)
The Composition and Structure of the Inorganic Core of Relaxed Intermediate X(Y122F) of E. coli Ribonucleotide Reductase (2016) (0)
Ribonucleotide reductase: no longer confusing but still amazing (1996) (0)
Identification of the Alkaline-Labile Product Accompanying Cytosine Release During Bleomycin-Mediated Degradation of d(CGCGCG). (1987) (0)
3 ° C-H Bond Cleavage by Ribonucleotide Diphosphate Reductase 1627 (2001) (0)
Catalysis and regulation. Editorial overview. (2008) (0)
Quaternary Structure and Activity Modulation in Human Ribonucleotide Reductase (2015) (0)
Ribonucleotide Reductase Dimanganese(II)-NrdF from Escherichia coli in Complex with Reduced NrdI with a Trapped Peroxide (2010) (0)
Altered Pathway Routing in a Class ofSalmonella enterica Serovar Typhimurium Mutants Defective in Aminoimidazole Ribonucleotide Synthetase (2001) (0)
Root Cause Analysis of the Unexpected Behaviour of a Flaked Material Under Irradiation and Transferability to the Doel 3/Tihange 2 Reactor Pressure Vessels (2016) (0)
B12-dependent ribonucleotide reductase: another piece of the puzzle (2000) (0)
Ribonucleotide reductase R1 subunit of E. coli to 2.3 A resolution (2010) (0)
A hot oxidant, 3-NO[subscript 2]Y[subscript 122] radical, unmasks conformational gating in reductase (2010) (0)
EXAFS Studies of the B2 Subunit of the Ribonucleotide Reductase from E. coli. (1987) (0)
Mechanism of assembly of the tyrosyl radical-diferric cluster cofactor of E. coli ribonucleotide reductase. (1991) (0)
Circumferential cracking in steam generator tubes repaired by mechanical sleeving (1995) (0)
Is OD peening of Alloy 800 SG tubes desirable (1992) (0)
General Torsional Fatigue of Turbogroup Shafts Due to Electrical Disturbances (1988) (0)
Ribonucleotide Reductase NrdF from Escherichia coli Soaked with Ferrous Ions (2010) (0)
Glutamate 350 plays an essential role in conformational gating of long range radical transport in E. coli class Ia ribonucleotide reductase (2017) (0)
Structure of the Ribonucleotide Reductase Rnr2 Homodimer from Saccharomyces cerevisiae (2004) (0)
Properties of Site-Specifically Incorporated 3-Aminotyrosine in Proteins to Study Redox-Active Tyrosines: E. coli Ribonucleotide Reductase as a Paradigm (2018) (0)
Low resolution crystal structure of human ribonucleotide reductase alpha6 hexamer in complex with dATP (2016) (0)
Fluorinated click-derived tripodal ligands drive spin crossover in both iron(II) and cobalt(II) complexes. (2022) (0)
A Binuclear Cobalt Complex in the Electrochemical Water Oxidation Reaction (2022) (0)
Back Cover: Isomerization Reactions in Anionic Mesoionic Carbene‐Borates and Control of Properties and Reactivities in the Resulting Co II Complexes through Agostic Interactions (Angew. Chem. Int. Ed. 1/2021) (2020) (0)
B12-dependent ribonucleotide reductase: paradox or paradigm? (2001) (0)
Composition and Structure of the Inorganic Core of Relaxed Intermediate (2015) (0)
Cover Feature: Highly Electrophilic, Catalytically Active and Redox‐Responsive Cobaltoceniumyl and Ferrocenyl Triazolylidene Coinage Metal Complexes (Chem. Eur. J. 15/2018) (2018) (0)

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