Joël Bockaert
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French biologist
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Joël Bockaert's Degrees
- PhD Biochemistry University of Strasbourg
- Masters Biochemistry University of Strasbourg
- Bachelors Biology University of Strasbourg
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Why Is Joël Bockaert Influential?
(Suggest an Edit or Addition)According to Wikipedia, Joël Bockaert is a French biologist. Biography He was a student at the École Normale d'Instituteur in Mérignac from 1961 to 1964 and at the École Normale supérieure-Rue d'Ulm-Paris from 1964 to 1968.
Joël Bockaert's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Molecular tinkering of G protein‐coupled receptors: an evolutionary success (1999) (1485)
- NMDA-dependent superoxide production and neurotoxicity (1993) (1238)
- Differential signal transduction by five splice variants of the PACAP receptor (1993) (1208)
- Glutamate stimulates inositol phosphate formation in striatal neurones (1985) (769)
- NMDA receptors activate the arachidonic acid cascade system in striatal neurons (1988) (616)
- Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens (2002) (613)
- Metabotropic glutamate receptors: From the workbench to the bedside (2011) (562)
- Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors. (1990) (462)
- A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system. (1988) (435)
- “Inflammatory” Cytokines (2000) (409)
- Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy. (2007) (395)
- Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer (2001) (395)
- Localization and Mechanisms of Action of Cannabinoid Receptors at the Glutamatergic Synapses of the Mouse Nucleus Accumbens (2001) (374)
- Nitric oxide-induced blockade of NMDA receptors (1992) (345)
- Functional coupling between ryanodine receptors and L-type calcium channels in neurons (1996) (322)
- Direct activation of GTP‐binding regulatory proteins (G‐proteins) by substance P and compound 48/80 (1990) (300)
- Complex interactions between mGluRs, intracellular Ca2+ stores and ion channels in neurons (2000) (295)
- Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP-38) Protects Cerebellar Granule Neurons from Apoptosis by Activating the Mitogen-Activated Protein Kinase (MAP Kinase) Pathway (1997) (293)
- Shank Expression Is Sufficient to Induce Functional Dendritic Spine Synapses in Aspiny Neurons (2005) (290)
- GPCR interacting proteins (GIP). (2004) (275)
- Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1 (1995) (272)
- mTOR in Brain Physiology and Pathologies. (2015) (250)
- Pharmacological characterization of the D2 dopamine receptor negatively coupled with adenylate cyclase in rat anterior pituitary. (1983) (248)
- Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation (2006) (245)
- Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain (1997) (245)
- A new mechanism for glutamate receptor action: phosphoinositide hydrolysis (1988) (242)
- Inflammatory reactions in human medial temporal lobe epilepsy with hippocampal sclerosis (2002) (241)
- The 5-HT4 receptor: a place in the sun. (1992) (240)
- Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes. (1992) (237)
- Alternative Splicing in the N-terminal Extracellular Domain of the Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Receptor Modulates Receptor Selectivity and Relative Potencies of PACAP-27 and PACAP-38 in Phospholipase C Activation* (1996) (237)
- Arachidonic acid released from striatal neurons by joint stimulation of ionotropic and metabotropic quisqualate receptors (1990) (236)
- Systems medicine and integrated care to combat chronic noncommunicable diseases (2011) (230)
- Dendritic and Axonal Targeting of Type 5 Metabotropic Glutamate Receptor Is Regulated by Homer1 Proteins and Neuronal Excitation (2000) (230)
- Central 5-HT4 receptors. (1995) (227)
- The ‘magic tail’ of G protein‐coupled receptors: an anchorage for functional protein networks (2003) (224)
- Differential G protein-mediated coupling of D2 dopamine receptors to K+ and Ca2+ currents in rat anterior pituitary cells (1992) (221)
- Engineering GPCR signaling pathways with RASSLs (2008) (220)
- Adenylyl cyclase activities in ovarian tissues. I. Homogenization and conditions of assay in graafian follicles and corpora lutea of rabbits, rats, and pigs: regulation by ATP, and some comparative properties. (1976) (214)
- Cytokine signals propagate through the brain (2000) (202)
- Two distinct mechanisms, differentially affected by excitatory amino acids, trigger GABA release from fetal mouse striatal neurons in primary culture (1989) (198)
- Nitric oxide, superoxide and peroxynitrite: Putative mediators of NMDA-induced cell death in cerebellar granule cells (1993) (197)
- Domains involved in the specificity of G protein activation in phospholipase C‐coupled metabotropic glutamate receptors. (1994) (196)
- Pharmacological characterization of 5-hydroxytryptamine4(5-HT4) receptors positively coupled to adenylate cyclase in adult guinea pig hippocampal membranes: effect of substituted benzamide derivatives. (1990) (196)
- Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain. (1999) (192)
- Regional distribution and ontogeny of 5-HT4 binding sites in rodent brain (1994) (191)
- Hormone-stimulated desensitization of hormone-dependent adenylyl cyclase. Dual action of luteninizing hormone on pig graafian follicle membranes. (1976) (189)
- Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens (2007) (189)
- Synaptogenesis of cultured striatal neurons in serum-free medium: a morphological and biochemical study. (1986) (187)
- PAC1 receptor-deficient mice display impaired insulinotropic response to glucose and reduced glucose tolerance. (2000) (186)
- Synaptic multiprotein complexes associated with 5‐HT2C receptors: a proteomic approach (2002) (181)
- 5-HT4 Receptors (2004) (177)
- GPCR-jacking: from a new route in RTK signalling to a new concept in GPCR activation. (2007) (175)
- The Serotonin 5-HT2A and 5-HT2C Receptors Interact with Specific Sets of PDZ Proteins* (2004) (173)
- Interaction of substance P, compound 4880 and mastoparan with the α-subunit C-terminus of G protein (1990) (172)
- Attenuated Response to Stress and Novelty and Hypersensitivity to Seizures in 5-HT4 Receptor Knock-Out Mice (2004) (171)
- Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses (1995) (170)
- Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity (2007) (168)
- BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity. (2001) (167)
- hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer. (1998) (167)
- The Ca2+/Cl− dependent L‐[3H]glutamate binding: a new receptor or a particular transport process? (1984) (165)
- GPCR interacting proteins (GIPs) in the nervous system: Roles in physiology and pathologies. (2010) (161)
- The Second Intracellular Loop of Metabotropic Glutamate Receptor 1 Cooperates with the Other Intracellular Domains to Control Coupling to G-proteins (*) (1996) (159)
- 5-HT1B receptors are negatively coupled with adenylate cyclase in rat substantia nigra. (1988) (157)
- GLP-1 Mediates Antiapoptotic Effect by Phosphorylating Bad through a β-Arrestin 1-mediated ERK1/2 Activation in Pancreatic β-Cells (2009) (155)
- Homer-Dependent Cell Surface Expression of Metabotropic Glutamate Receptor Type 5 in Neurons (2002) (151)
- Changes in the carboxyl-terminal domain of metabotropic glutamate receptor 1 by alternative splicing generate receptors with differing agonist-independent activity. (1996) (150)
- Proteomic Analysis of Astrocytic Secretion in the Mouse (2003) (149)
- Interaction of Serotonin 5-Hydroxytryptamine Type 2C Receptors with PDZ10 of the Multi-PDZ Domain Protein MUPP1* (2001) (148)
- Activation of a Large‐conductance Ca2+‐Dependent K+ Channel by Stimulation of Glutamate Phosphoinositide‐coupled Receptors in Cultured Cerebellar Granule Cells (1991) (146)
- Molecular Characterization of a Purified 5-HT4 Receptor (2005) (146)
- Get receptive to metabotropic glutamate receptors (1995) (144)
- Pharmacology of 5-hydroxytryptamine-1A receptors which inhibit cAMP production in hippocampal and cortical neurons in primary culture. (1988) (142)
- 5-HT6 receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia (2012) (142)
- A 5-HT receptor in the central nervous system, positively coupled with adenylate cyclase, is antagonized by ICS 205 930. (1988) (141)
- Characterization of subtypes of excitatory amino acid receptors involved in the stimulation of inositol phosphate synthesis in rat brain synaptoneurosomes. (1987) (141)
- Epileptiform Activity Induces Vascular Remodeling and Zonula Occludens 1 Downregulation in Organotypic Hippocampal Cultures: Role of VEGF Signaling Pathways (2011) (138)
- Comparative effect of l-CCG-I, DCG-IV and γ-carboxy-l-glutamate on all cloned metabotropic glutamate receptor subtypes (1998) (137)
- New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4(a) receptor splice variant: roles in receptor targeting (2004) (136)
- Glutamate receptors induce a burst of superoxide via activation of nitric oxide synthase in arginine-depleted neurons. (1994) (136)
- Increased number of neural progenitors in human temporal lobe epilepsy (2005) (134)
- An α 40 subunit of a GTP-Binding protein immunologically related to G0 mediates a dopamine-induced decrease of Ca2+ current in snail neurons (1988) (133)
- Topographical distribution of dopaminergic innervation and dopaminergic receptors of the anterior cerebral cortex of the rat (1978) (132)
- The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells (1994) (132)
- Serotonin increases calcium current in human atrial myocytes via the newly described 5-hydroxytryptamine4 receptors. (1992) (131)
- D2-dopamine receptor-mediated inhibition of cyclic AMP formation in striatal neurons in primary culture. (1985) (130)
- Shaggy, the Homolog of Glycogen Synthase Kinase 3, Controls Neuromuscular Junction Growth in Drosophila (2004) (128)
- Cloning and Functional Expression of a DrosophilaMetabotropic Glutamate Receptor Expressed in the Embryonic CNS (1996) (126)
- Presence of three pertussis toxin substrates and Goα immunoreactivity in both plasma and granule membranes of chromaffin cells (1987) (123)
- Chitinase 3-like proteins as diagnostic and prognostic biomarkers of multiple sclerosis (2015) (119)
- Lesion Study of the Distribution of Serotonin 5‐HT4 Receptors in Rat Basal Ganglia and Hippocampus (1996) (118)
- 5-HT4 Receptors Improve Social Olfactory Memory in the Rat (1997) (118)
- Endogenous Amino Acid Release from Cultured Cerebellar Neuronal Cells: Effect of Tetanus Toxin on Glutamate Release (1989) (118)
- Selective Blockade of P/Q-Type Calcium Channels by the Metabotropic Glutamate Receptor Type 7 Involves a Phospholipase C Pathway in Neurons (2000) (118)
- A model for the functioning of family 3 GPCRs. (2002) (118)
- Frontocortical 5-HT4 receptors exert positive feedback on serotonergic activity: Viral transfections, subacute and chronic treatments with 5-HT4 agonists (2005) (114)
- Direct Interaction Enables Cross-talk between Ionotropic and Group I Metabotropic Glutamate Receptors* (2008) (114)
- Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons (2007) (113)
- (trans)-1-amino-cyclopentyl-1,3-dicarboxylate stimulates quisqualate phosphoinositide-coupled receptors but not ionotropic glutamate receptors in striatal neurons and Xenopus oocytes. (1990) (113)
- Visualization of Cyclic AMP–Regulated Presynaptic Activity at Cerebellar Granule Cells (1998) (111)
- The 5‐HT4 receptor subtype inhibits K+ current in colliculi neurones via activation of a cyclic AMP‐dependent protein kinase (1992) (111)
- GPCR-interacting proteins (GIPs): nature and functions. (2004) (110)
- Loss of expression of the candidate tumor suppressor gene ZAC in breast cancer cell lines and primary tumors (1999) (109)
- Differential expression of pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide receptor subtypes in clonal pituitary somatotrophs and gonadotrophs. (1995) (108)
- Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists. (1996) (106)
- ERK1/2 Control Phosphorylation and Protein Level of cAMP-Responsive Element–Binding Protein (2006) (105)
- Metabotropic Glutamate Receptors in the Rat Nucleus Accumbens (1997) (104)
- Cannabinoids inhibit GABAergic synaptic transmission in mice nucleus accumbens. (2001) (103)
- Evidence for a glutamate receptor of the AMPA subtype which mediates insulin release from rat perfused pancreas (1992) (103)
- Topographical distribution of dopaminergic innervation and of dopaminergic receptors in the rat striatum. II. Distribution and characteristics of dopamine adenylate cyclase — Interaction of d-LSD with dopaminergic receptors (1976) (103)
- 5-HT6 receptors positively coupled to adenylyl cyclase in striatal neurones in culture. (1994) (103)
- Inverse Agonist and Neutral Antagonist Actions of Antidepressants at Recombinant and Native 5-Hydroxytryptamine2C Receptors: Differential Modulation of Cell Surface Expression and Signal Transduction (2008) (101)
- Glutamate stimulates glucagon secretion via an excitatory amino acid receptor of the AMPA subtype in rat pancreas. (1993) (99)
- SL65.0155, A Novel 5-Hydroxytryptamine4 Receptor Partial Agonist with Potent Cognition-Enhancing Properties (2002) (99)
- [3H]-GR113808 labels 5-HT4 receptors in the human and guinea-pig brain. (1993) (98)
- L-nitroarginine, an inhibitor of NO synthase, dramatically worsens limbic epilepsy in rats. (1993) (97)
- Serotonin: A New Hope in Alzheimer's Disease? (2015) (97)
- Role of cyclic AMP in a serotonin-evoked slow inward current in snail neurones (1981) (96)
- Serotonin 5-HT1 receptors mediate inhibition of cyclic AMP production in neurons. (1986) (95)
- Pharmacological characterization of metabotropic glutamate receptors in several types of brain cells in primary cultures. (1994) (95)
- Homer1a-Dependent Crosstalk Between NMDA and Metabotropic Glutamate Receptors in Mouse Neurons (2010) (95)
- The gastrointestinal prokinetic benzamide derivatives are agonists at the non-classical 5-HT receptor (5-HT4) positively coupled to adenylate cyclase in neurons (1989) (95)
- Postsynaptic serotonin-sensitive adenylate cyclase in the central nervous system. I. Development and distribution of serotonin and dopamine-sensitive adenylate cyclases in rat and guinea pig brain. (1978) (94)
- Identification and functional roles of metabotropic glutamate receptor-interacting proteins. (2004) (93)
- 5-HT4 receptors: History, molecular pharmacology and brain functions (2008) (93)
- Further evidence that desensitization of beta-adrenergic-sensitive adenylate cyclase proceeds in two steps. Modification of the coupling and loss of beta-adrenergic receptors. (1980) (93)
- BIMU1 Increases Associative Memory in Rats by Activating 5-HT4 Receptors (1997) (92)
- cAMP-mediated decrease in K+ conductance evoked by serotonin and dopamine in the same neuron: a biochemical and physiological single-cell study. (1982) (92)
- cAMP-dependent, long-lasting inhibition of a K+ current in mammalian neurons. (1995) (91)
- PICK1 uncoupling from mGluR7a causes absence-like seizures (2008) (91)
- Stimulation of the ERK Pathway by GTP-loaded Rap1 Requires the Concomitant Activation of Ras, Protein Kinase C, and Protein Kinase A in Neuronal Cells* (2003) (90)
- Epac mediates PACAP‐dependent long‐term depression in the hippocampus (2009) (90)
- A Nitric Oxide Synthase Activity Selectively Stimulated by NMDA Receptors Depends on Protein Kinase C Activation in Mouse Striatal Neurons (1992) (89)
- VRX-03011, a novel 5-HT4 agonist, enhances memory and hippocampal acetylcholine efflux (2007) (88)
- Coassembly of Two GluR6 Kainate Receptor Splice Variants within a Functional Protein Complex (2005) (87)
- Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth. (2014) (87)
- Adenosine-sensitive adenylate cyclase in rat striatal homogenates and its relationship to dopamine- and Ca2+-sensitive adenylate cyclases. (1977) (87)
- Differential signal transduction by six splice variants of the pituitary adenylate cyclase-activating peptide (PACAP) receptor. (1995) (86)
- Involvement of divalent ions in the nitric oxide-induced blockade of N-methyl-D-aspartate receptors in cerebellar granule cells. (1995) (83)
- The Drosophila Metabotropic Glutamate Receptor DmGluRA Regulates Activity-Dependent Synaptic Facilitation and Fine Synaptic Morphology (2004) (83)
- Physical interaction of calmodulin with the 5-hydroxytryptamine2C receptor C-terminus is essential for G protein-independent, arrestin-dependent receptor signaling. (2008) (83)
- Characteristics of dopamine and β-adrenergic sensitive adenylate cyclases in the frontal cerebral cortex of the rat. Comparative effects of neuroleptics on frontal cortex and striatal dopamine sensitive adenylate cyclases (1977) (82)
- Differential modulation of the 5-HT4 receptor agonists and antagonist on rat learning and memory (2000) (82)
- Inhibition of brain adenylate cyclase by A1 adenosine receptors: Pharmacological characteristics and locations (1983) (82)
- Is the dopamine sensitive adenylate cyclase in the rat substantia nigra coupled with ‘autoreceptors’? (1976) (81)
- PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7 (2002) (81)
- BRL 24924: a potent agonist at a non-classical 5-HT receptor positively coupled with adenylate cyclase in colliculi neurons. (1989) (80)
- Presynaptic serotonin 2A receptors modulate thalamocortical plasticity and associative learning (2016) (80)
- Cytokine signals propagate through the brain (2000) (80)
- A Cluster of Basic Residues in the Carboxyl-terminal Tail of the Short Metabotropic Glutamate Receptor 1 Variants Impairs Their Coupling to Phospholipase C* (1998) (79)
- Adenosine-sensitive adenylate cyclase in rat brain homogenates: kinetic characteristics, specificity, topographical, subcellular and cellular distribution. (1979) (79)
- The proteomic analysis of mouse choroid plexus secretome reveals a high protein secretion capacity of choroidal epithelial cells (2006) (79)
- The G protein-coupling profile of metabotropic glutamate receptors, as determined with exogenous G proteins, is independent of their ligand recognition domain. (1998) (79)
- G Protein Activation by Serotonin Type 4 Receptor Dimers (2011) (79)
- Adaptive changes in serotonin neurons of the raphe nuclei in 5‐HT4 receptor knock‐out mouse (2006) (77)
- Non-dopaminergic fibres may regulate dopamine-sensitive adenylate cyclase in the prefrontal cortex and nucleus accumbens (1982) (76)
- Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-hydroxytryptamine2C receptor desensitization and membrane stability. (2006) (75)
- Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer’s disease (2013) (75)
- Alzheimer culprits: cellular crossroads and interplay. (2012) (75)
- Characteristics and metabolism of alpha 1 adrenergic receptors in a nonfusing muscle cell line. (1982) (74)
- mGluR7‐like metabotropic glutamate receptors inhibit NMDA‐mediated excitotoxicity in cultured mouse cerebellar granule neurons (1999) (74)
- Subcellular imaging of dynamic protein interactions by bioluminescence resonance energy transfer. (2008) (73)
- A nitric oxide (NO) synthase inhibitor accelerates amygdala kindling. (1992) (73)
- G proteins and G-protein-coupled receptors: structure, function and interactions (1991) (73)
- Stimulation by glutamate receptors of arachidonic acid release depends on the Na+/Ca2+ exchanger in neuronal cells. (1993) (72)
- International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function (2020) (72)
- 5-hydroxytryptamine 4 receptor activation of the extracellular signal-regulated kinase pathway depends on Src activation but not on G protein or beta-arrestin signaling. (2007) (71)
- Metabotropic glutamate receptor 2/3‐dependent long‐term depression in the nucleus accumbens is blocked in morphine withdrawn mice (2002) (71)
- G protein-coupled receptors: dominant players in cell-cell communication. (2002) (70)
- 5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10. (2013) (70)
- Immunocytochemical localization of the guanine nucleotide-binding protein Go in primary cultures of neuronal and glial cells (1988) (70)
- Decreased Presynaptic Sensitivity to Adenosine after Cocaine Withdrawal (1998) (69)
- Cloning, expression and pharmacology of the mouse 5‐HT4L receptor (1996) (69)
- β‐arrestin1 phosphorylation by GRK5 regulates G protein‐independent 5‐HT4 receptor signalling (2009) (68)
- Non-classical glutamate receptors, blocked by both NMDA and non-NMDA antagonists, stimulate nitric oxide production in neurons (1993) (68)
- Extreme C Terminus of G Protein α-Subunits Contains a Site That Discriminates between Gi-coupled Metabotropic Glutamate Receptors* (1998) (68)
- PACAP type I receptor transactivation is essential for IGF‐1 receptor signalling and antiapoptotic activity in neurons (2007) (68)
- Comparative effects of PACAP and VIP on pancreatic endocrine secretions and vascular resistance in rat (1996) (68)
- Dual action of excitatory amino acids on the metabolism of inositol phosphates in striatal neurons. (1987) (67)
- Cerebellar granule cell survival and maturation induced by K+ and NMDA correlate with c-fos proto-oncogene expression (1989) (67)
- Transfection of human 5-hydroxytryptamine1A receptors in NIH-3T3 fibroblasts: effects of increasing receptor density on the coupling of 5-hydroxytryptamine1A receptors to adenylyl cyclase. (1992) (66)
- Tritium labelling of 8‐lysine vasopressin and its purification by affinity chromatography on sepharose bound neurophysins (1972) (65)
- 5-HT(4) receptors, a place in the sun: act two. (2011) (65)
- Identity of [3H]-dihydroalprenolol binding sites and beta-adrenergic receptors coupled with adenylate cyclase in the central nervous system: pharmacological properties, distribution and adaptive responsiveness. (1979) (65)
- Characterization of homologous 5-hydroxytryptamine4 receptor desensitization in colliculi neurons. (1992) (64)
- Characterization of the Methylation-sensitive Promoter of the Imprinted ZAC Gene Supports Its Role in Transient Neonatal Diabetes Mellitus* (2001) (64)
- Neurotransmitter‐Induced Inositol Phosphate Formation in Neurons in Primary Culture (1988) (64)
- α1 and α2 Adrenergic receptors in mouse brain astrocytes from primary cultures (1981) (63)
- Postsynaptic serotonin-sensitive adenylate cyclase in the central nervous system. II. Comparison with dopamine- and isoproterenol-sensitive adenylate cyclases in rat brain. (1978) (63)
- Akt mediates the anti‐apoptotic effect of NMDA but not that induced by potassium depolarization in cultured cerebellar granule cells (2002) (63)
- Characterization of a metabotropic glutamate receptor: direct negative coupling to adenylyl cyclase and involvement of a pertussis toxin-sensitive G protein. (1992) (62)
- A Single Mutation in the 5-HT4 Receptor (5-HT4-R D100(3.32)A) Generates a Gs-coupled Receptor Activated Exclusively by Synthetic Ligands (RASSL)* (2003) (62)
- Modulation of calcium channels by metabotropic glutamate receptors in cerebellar granule cells (1995) (62)
- Plant Insecticide L-Canavanine Repels Drosophila via the Insect Orphan GPCR DmX (2009) (62)
- Pharmacological characterization of the quisqualate receptor coupled to phospholipase C (Qp) in striatal neurons. (1991) (62)
- The PACAP receptor: generation by alternative splicing of functional diversity among G protein-coupled receptors in nerve cells. (1994) (61)
- Nitric Oxide-Induced Blockade of NMDA Receptors (2013) (60)
- Immunological localization of the GTP-binding protein Go in different tissues of vertebrates and invertebrates. (1987) (60)
- Characteristics of the β 1- and β 2-adrenergic-sensitive adenylate cyclases in glial cell primary cultures and their comparison with β 2-adrenergic-sensitive adenylate cyclase of meningeal cells (1981) (60)
- Mild deficits in mice lacking pituitary adenylate cyclase-activating polypeptide receptor type 1 (PAC1) performing on memory tasks. (2000) (60)
- A simple method to transfer plasmid DNA into neuronal primary cultures: functional expression of the mGlu5 receptor in cerebellar granule cells (1999) (60)
- Degradation of cAMP-Responsive Element–Binding Protein by the Ubiquitin-Proteasome Pathway Contributes to Glucotoxicity in β-Cells and Human Pancreatic Islets (2009) (59)
- Concomitant induction of apoptosis and necrosis in cerebellar granule cells following serum and potassium withdrawal (1997) (59)
- Muscle Dystroglycan Organizes the Postsynapse and Regulates Presynaptic Neurotransmitter Release at the Drosophila Neuromuscular Junction (2008) (59)
- Dynamic remodeling of scaffold interactions in dendritic spines controls synaptic excitability (2012) (59)
- The neuronal death induced by endotoxic shock but not that induced by excitatory amino acids requires TNF‐α (1998) (59)
- An islet activating protein-sensitive G protein is involved in dopamine inhibition of angiotensin and thyrotropin-releasing hormone-stimulated inositol phosphate production in anterior pituitary cells. (1987) (59)
- The nucleus accumbens 5-HTR4-CART pathway ties anorexia to hyperactivity (2012) (58)
- 5-Hydroxytryptamine1A receptor synthetic peptides. Mechanisms of adenylyl cyclase inhibition. (1994) (58)
- Caffeic acid phenethyl ester (CAPE) prevents inflammatory stress in organotypic hippocampal slice cultures. (2003) (56)
- 5-HT1A-sensitive adenylyl cyclase of rodent hippocampal neurons: effects of antidepressant treatments and chronic stimulation with agonists. (1991) (56)
- The resolution of dopamine and β1- and β2-adrenergic-sensitive adenylate cyclase activities in homogenates of cat cerebellum, hippocampus and cerebral cortex (1979) (55)
- Dynamic reorganization of the astrocyte actin cytoskeleton elicited by cAMP and PACAP: a role for phosphatidylInositol 3‐kinase inhibition (2005) (53)
- Glutamate stimulates insulin secretion and improves glucose tolerance in rats. (1995) (53)
- NMDA- and kainate-evoked GABA release from striatal neurones differentiated in primary culture: Differential blocking by phencyclidine (1988) (53)
- Facilitatory coupling between a glutamate metabotropic receptor and dihydropyridine-sensitive calcium channels in cultured cerebellar granule cells (1995) (53)
- Conformational Toggle Switches Implicated in Basal Constitutive and Agonist-Induced Activated States of 5-Hydroxytryptamine-4 Receptors (2009) (53)
- Rapid, sensitive, and simple method for quantification of both neurotoxic and neurotrophic effects of NMDA on cultured cerebellar granule cells (1990) (53)
- Regional distribution and ontogeny of 5-HT4 binding sites in rat brain (1995) (52)
- 5‐HT4 Receptors: Cloning and Expression of New Splice Variants (1998) (52)
- Knock-In Mice Lacking the PDZ-Ligand Motif of mGluR7a Show Impaired PKC-Dependent Autoinhibition of Glutamate Release, Spatial Working Memory Deficits, and Increased Susceptibility to Pentylenetetrazol (2008) (52)
- Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities (2001) (52)
- Neuronal, glial and meningeal localizations of neurotransmitter-sensitive adenylate cyclases in cerebral cortex of mice (1981) (52)
- Complex interaction between quisqualate and kainate receptors as revealed by measurement of GABA release from striatal neurons in primary culture. (1989) (52)
- Sodium nitroprusside blocks NMDA receptors via formation of ferrocyanide ions. (1992) (51)
- Shank3-Rich2 Interaction Regulates AMPA Receptor Recycling and Synaptic Long-Term Potentiation (2013) (51)
- Modulation of memory processes and cellular excitability in the dentate gyrus of freely moving rats by a 5-HT4 receptors partial agonist, and an antagonist (2004) (51)
- Use of (-)-[3H]dihydroalprenolol to study beta adrenergic receptor-adenylate cyclase coupling in C6 glioma cells: role of 5'-guanylylimidodiphosphate. (1977) (51)
- Serotonin-sensitive adenylate cyclase and [3H]serotonin binding sites in the CNS of the rat--II. Respective regional and subcellular distributions and ontogenetic developments. (1980) (51)
- Modulation of big K+ channel activity by ryanodine receptors and L‐type Ca2+ channels in neurons (1998) (50)
- PAC1 Null Females Display Decreased Fertility (2000) (50)
- The melatonergic agonist and clinically active antidepressant, agomelatine, is a neutral antagonist at 5-HT(2C) receptors. (2011) (50)
- Dual mechanisms of inhibition by dopamine of basal and thyrotropin-releasing hormone-stimulated inositol phosphate production in anterior pituitary cells. Evidence for an inhibition not mediated by voltage-dependent Ca2+ channels. (1990) (50)
- Uncoupling and Endocytosis of 5-Hydroxytryptamine 4 Receptors (2005) (50)
- Metabotropic glutamate receptors: an original family of G protein‐coupled receptors (1993) (49)
- Enhanced detection of CNS cell secretome in plasma protein-depleted cerebrospinal fluid. (2008) (49)
- Phosphorylation of β-arrestin2 at Thr383 by MEK underlies β-arrestin-dependent activation of Erk1/2 by GPCRs (2017) (49)
- Dialysis of lactotropes with antisense oligonucleotides assigns guanine nucleotide binding protein subtypes to their channel effectors. (1992) (49)
- Divergent Evolution in Metabotropic Glutamate Receptors (2004) (48)
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- Neurobiology of Go (1993) (2)
- [The anxiogenic effects of SSRI are mediated by 5-HT2c receptors of the stria terminalis]. (2017) (2)
- Turn on and turn off reactions of β‐adrenergic‐sensitive adenylate cyclase in control and desensitized C6 glioma cells (1982) (2)
- Faculty Opinions recommendation of G protein-regulated endocytic trafficking of adenylyl cyclase type 9. (2021) (2)
- The resolution of dopamine and beta 1- and beta 2-adrenergic-sensitive adenylate cyclase activities in homogenates of cat cerebellum, hippocampus and cerebral cortex. (1979) (1)
- P.1.002 Cognitive deficits due to chronic consumption of Δ9-tetrahydrocannabinol during adolescence: role of 5-HT6-mTOR pathway (2016) (1)
- Chapter 13:Functional Crosstalk between Group I Metabotropic Glutamate Receptors and Ionotropic Glutamate Receptors Controls Synaptic Transmission (2011) (1)
- The drosophila metabotropic receptor dmglura is an homologue of mammalian group-II mGluRs (1996) (1)
- Techniques for studying inverse agonist activity of antidepressants at recombinant nonedited 5-HT(₂C-INI) receptor and native neuronal 5-HT(₂C) receptors. (2010) (1)
- Brain PACAP/VIP receptors: regional distribution, functional properties and physiological relevance. (2000) (1)
- Impact of 5-HT6 Receptor Subcellular Localization on Its Signaling and Its Pathophysiological Roles (2023) (1)
- Faculty Opinions recommendation of Sex-specific transcriptional and proteomic signatures in schizophrenia. (2019) (1)
- Faculty Opinions recommendation of Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala. (2016) (1)
- Early 5‐HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse (2022) (1)
- Faculty Opinions recommendation of Illuminating G-Protein-Coupling Selectivity of GPCRs. (2021) (1)
- Intracellular and Intercellular Messengers Produced by Metabotropic (Qp), AMPA, and NMDA Excitatory Amino Acid Receptors (1991) (1)
- [The mTOR pathway: a new target for treating cognitive deficits of schizophrenia?]. (2013) (1)
- PL-1 Metabotropic receptors: Ten years of research (1995) (1)
- Specific aminoacid residues control G-protein coupling efficacy in mGluR1 (1996) (1)
- Metabotropic glutamate receptors (mGluRs) are coupled to voltage-activated Ca2+ channels via ryanodine receptors (1996) (1)
- Arachidonic acid and nitric oxide production by glutamate receptors in cultured neurons (1993) (1)
- Maitotoxin-evoked gamma-aminobutyric acid release is due not only to the opening of calcium channels. (1988) (1)
- S.12.02 GPRIN1, a new 5-HT6 receptor partner involved in its constitutive activity and receptor-induced neuronal differentiation (2016) (1)
- Faculty Opinions recommendation of Discovery of Novel pERK1/2- or β-Arrestin-Preferring 5-HT1A Receptor-Biased Agonists: Diversified Therapeutic-like versus Side Effect Profile. (2021) (0)
- VASOPRESSIN-SENSITIVE ADENYLATE CYCLASE FROM THE MAMMALIAN KIDNEY (1976) (0)
- Nmda prevention of cerebellar granule cells apoptosis is related to caspase 3 inhibition role of protein kinases (2002) (0)
- Faculty Opinions recommendation of Dynorphin A activates bradykinin receptors to maintain neuropathic pain. (2006) (0)
- Faculty Opinions recommendation of Discovery of β-Arrestin Biased Ligands of 5-HT7R. (2021) (0)
- Faculty Opinions recommendation of Direct visualization of cAMP signaling in primary cilia reveals up-regulation of ciliary GPCR activity following Hedgehog activation. (2021) (0)
- Faculty Opinions recommendation of Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane. (2006) (0)
- Triggering of Arachidonic Acid Release from Mature Striatal Neurons by Associative Stimulation of Ionotropic (AMPA) and Quisqualate Receptors Coupled to Phospholipase C (Qp) (1991) (0)
- Faculty Opinions recommendation of Mechanism of β2AR regulation by an intracellular positive allosteric modulator. (2019) (0)
- Faculty Opinions recommendation of Direct targeting of Gαq and Gα11 oncoproteins in cancer cells. (2019) (0)
- Faculty Opinions recommendation of Biased signaling of the mu opioid receptor revealed in native neurons. (2019) (0)
- Faculty Opinions recommendation of Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo. (2006) (0)
- S.09.02 The metabotropic glutamate receptors: Structural domains and coupling to G proteins (1997) (0)
- Faculty Opinions recommendation of SnapShot: β-Arrestin Functions. (2021) (0)
- Faculty Opinions recommendation of Biased signalling: from simple switches to allosteric microprocessors. (2021) (0)
- Genopole Languedoc-Roussillon Montpellier: A new interface for animal and plant genome research [S04-14] (2003) (0)
- Faculty Opinions recommendation of Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. (2021) (0)
- Faculty Opinions recommendation of Constitutive activity of 5-HT receptors: Factual analysis. (2021) (0)
- Effects of NO on ionic channels (1998) (0)
- CO28 - Identification du premier exemple d’un gène impliqué dans l’influence du stress sur l’anorexie (2006) (0)
- [Monoclonal antibodies obtained against G-protein epitopes: comparison of immunoreactions seen in the brain, retina and striated muscular tissue]. (1991) (0)
- Faculty Opinions recommendation of The 5-HT1A receptor: Signaling to behavior. (2021) (0)
- New pharmacological drugs and assays to study metabotropic receptors (1996) (0)
- Faculty Opinions recommendation of Projections from neocortex mediate top-down control of memory retrieval. (2015) (0)
- Complex interactions of agonists with alpha 1-adrenoceptors in intact cells. (1988) (0)
- Faculty Opinions recommendation of Constitutive Activity of Serotonin Receptor 6 Regulates Human Cerebral Organoids Formation and Depression-like Behaviors. (2021) (0)
- Faculty Opinions recommendation of Serotonylation: serotonin signaling and epigenetics. (2021) (0)
- On the Modes of Regulation of Intracellular Cyclic AMP: Desensitization of Adenylyl Cyclases to Hormonal Stimulation and Compartmentalization of Cyclic AMP (1976) (0)
- Faculty Opinions recommendation of Pharmacological MRI to investigate the functional selectivity of 5-HT1A receptor biased agonists. (2021) (0)
- P.1.018 Modulation of glutamatergic synaptic transmission in prefrontal cortex by 5-HT2A receptors (2012) (0)
- P.1.004 Serotonin 5-HT2A receptor-dependent phosphorylation of glutamate mGLU2 at Ser843 promotes mGLU2-operated Gi/o signaling (2017) (0)
- Faculty Opinions recommendation of Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo. (2021) (0)
- [Hormone and neurotransmitter receptors; their mechanism of action]. (1988) (0)
- Faculty Opinions recommendation of Input-Specific Metaplasticity in the Visual Cortex Requires Homer1a-Mediated mGluR5 Signaling. (2021) (0)
- P.1.017 GPRIN1, a new 5-HT6 receptor partner involved in its constitutive activity and receptor-induced neuronal differentiation (2016) (0)
- [When two molecules involved in the regulation of mood meet: mutual modulation of the serotonin transporter and neuronal NO-synthase]. (2007) (0)
- Faculty Opinions recommendation of Interclass GPCR heteromerization affects localization and trafficking. (2021) (0)
- Faculty Opinions recommendation of Serotonergic plasticity in the dorsal raphe nucleus characterizes susceptibility and resilience to anhedonia. (2020) (0)
- Direct and indirect effects of sulfhydryl blocking agents on agonist and antagonist binding to central alpha 1- and alpha 2-adrenoceptors. (1984) (0)
- メテルゴリン,中枢5‐HT受容器しゃ断薬,による脳の5‐HTターンオーバの逆説的減少 (1978) (0)
- Faculty Opinions recommendation of Ocean acidification inhibits initial shell formation of oyster larvae by suppressing the biosynthesis of serotonin and dopamine. (2021) (0)
- G protein coupled receptors: structure, functions and mutation (1997) (0)
- Synthesis of conformationally-constrained analogs of glutamic acid as structural probes of glutamatergic receptors (1995) (0)
- 5 HT 4 agonists: novel promising agents for AD prevention. (Conférencière invitée) (2013) (0)
- The adipocyte Goa-immunoreactive polypeptide is different from the a subunit of the brain G . protein (2005) (0)
- 5 HT 4 agonists: novel promising agents for AD pr evention. (2013) (0)
- 初代培養線条体ニューロンにおいてD2‐ドーパミン作動性アゴニスト,キンピロールと8‐ブロモ‐cAMPはD2ドーパミン受容体mRNAレベルの変化なしにG0αGTP結合蛋白質mRNAに対し相反する効果を持つ (1993) (0)
- Faculty of 1000 evaluation for Lack of beta-arrestin signaling in the absence of active G proteins. (2018) (0)
- Activation of5-HTlA Receptors Expressed inNIH-3T3 Cells Induces FocusFormation andPotentiates EGF Effect onDNA Synthesis (1992) (0)
- Faculty Opinions recommendation of Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties. (2022) (0)
- Morphological and pharmacological studies of cortical and striatal neurons in culture (1985) (0)
- S.24.01 New view on the ligand-receptor interaction (2003) (0)
- S.24.04 Cognitive deficits of schizophrenia and their control by the mTOR pathway (2015) (0)
- S.01.02 Proteomics and phosphoproteomics for understanding cellular signalling and its disruption in CNS disorders (2014) (0)
- Faculty Opinions recommendation of Assembly of a GPCR-G Protein Complex. (2021) (0)
- Faculty of 1000 evaluation for Antidepressive effects of targeting ELK-1 signal transduction. (2018) (0)
- Faculty Opinions recommendation of Central 5-HT receptors and their function; present and future. (2021) (0)
- High and low affinity states of beta-adrenergic receptors and their coupling with the adenylate cyclase in a muscle cell line. (1981) (0)
- Molecular and Functional Characterization of Proteins Interacting with the C‐Terminal Domains of 5‐HT2 Receptors: Emergence of 5‐HT2 “Receptosomes” (2004) (0)
- VIP actions on cellular transduction mechanisms in striatal and cortical neurons in primary culture (1985) (0)
- P.1.c.013 GPRIN1, a new 5-HT6 receptor partner involved in its constitutive activity and receptor-induced neuronal differentiation (2017) (0)
- Adaptive Response of Beta-Adrenergic Sensitive Adenylate Cyclase System (1987) (0)
- SYNTHESIS AND DEGRADATION OF MEMBRANE-BOUND RECEPTORS (1984) (0)
- P.102 Spatio-temporal characterization of its expression pattern reveals new roles of the 5-HT6 receptor in neurodevelopment (2020) (0)
- Direct activation of G proteins: the mechanism off action of peptides on mast cells (1990) (0)
- 5-HT4 receptors: general pharmacology and control of ionic channels (1992) (0)
- Faculty Opinions recommendation of Neuronal GPCR controls innate immunity by regulating noncanonical unfolded protein response genes. (2011) (0)
- Erratum to “Molecular events involved in neuronal death induced in the mouse hippocampus by in vivo injection of kainic acid” [Mol. Brain Res. 93 (2001) 190–198] (2003) (0)
- Faculty Opinions recommendation of Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor. (2021) (0)
- Composition pharmaceutique comprenant un recepteur 5-ht4d100a, et ses applications therapeutiques. (2003) (0)
- [The reference site of the European Innovation Partnership on Active and Healthy Aging MACVIA-LR (the fight against chronic diseases for an active and healthy aging in Languedoc-Roussillon)]. (2015) (0)
- P.1.008 Recruitment of the mTOR complex 1 by 5-HT6 receptors: potential role in the cognitive deficits of schizophrenia (2012) (0)
- Faculty Opinions recommendation of Structural insights into emergent signaling modes of G protein-coupled receptors. (2021) (0)
- Competitive effect of Homier1a on group I mGLU receptor targeting and constitutive activity (2002) (0)
- Faculty Opinions recommendation of β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease. (2013) (0)
- Lack of involvement of dopaminergic and GABA neurones in the inhibitory effect of harmaline on the activity of striatal cholinergic neurones in the rat (1977) (0)
- P.1.007 A proteomic and functional analysis reveals that 5-HT6 receptors modulate neuronal differentiation by recruitment of Cdk5 (2013) (0)
- Faculty Opinions recommendation of A universal technology for monitoring G-protein-coupled receptor activation in vitro and noninvasively in live animals. (2008) (0)
- Faculty Opinions recommendation of Serotonin contribution to cardiac valve degeneration: new insights for novel therapies? (2021) (0)
- 1582 – β adrenergic receptors in C6 glioma cells and central nervous system (1978) (0)
- TURNING ON TWO PROTOMERS IS Receptor Dimers : EVIDENCE THAT G Protein Activation by Serotonin Type 4 Signal Transduction : (2011) (0)
- Up-regulation in late pregnancy of both Go1 alpha and Go2 alpha isoforms in human myometrium. (1994) (0)
- Faculty Opinions recommendation of DARK classics in chemical neuroscience: nbomes. (2021) (0)
- S.04.02 Recruitment of the mTOR complex 1 by 5-HT6 receptors: potential role in the cognitive deficits of schizophrenia (2012) (0)
- CROSS-TALK BETWEEN IONOTROPIC AND GROUP-I METABOTROPIC GLUTAMATE RECEPTORS (2007) (0)
- Author response: Phosphorylation of β-arrestin2 at Thr383 by MEK underlies β-arrestin-dependent activation of Erk1/2 by GPCRs (2017) (0)
- Prodromal stimulation of 5 HT4 receptors reduces amyloid pathology in 5XFAD mice. (2012) (0)
- An alpha40 subunit of a GTP-binding protein immunologically related to G0 mediates a dopamine-induced decrease of Ca2+ current in snail neurons.. (2008) (0)
- Faculty Opinions recommendation of Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking. (2021) (0)
- Faculty Opinions recommendation of Stochastic synaptic plasticity underlying compulsion in a model of addiction. (2019) (0)
- Faculty Opinions recommendation of Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling. (2009) (0)
- Repartition and drug sensitivity of dopamine and L-isoproterenol-sensitive adenylate cyclases in rat brain homogenates. (1976) (0)
- Faculty Opinions recommendation of Genetic variation in the social environment contributes to health and disease. (2018) (0)
- Structure-function of metabotropic glutamate receptors (1995) (0)
- Faculty Opinions recommendation of Juvenile antioxidant treatment prevents adult deficits in a developmental model of schizophrenia. (2014) (0)
- Faculty of 1000 evaluation for Activity patterns of serotonin neurons underlying cognitive flexibility. (2018) (0)
- Faculty Opinions recommendation of Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior. (2012) (0)
- Faculty Opinions recommendation of Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor. (2021) (0)
- S.07.01 A proteomic and functional analysis reveals that 5-HT6 receptors modulate neuronal differentiation by recruitment of Cdk5 (2013) (0)
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