Johan Neyts

Q: What Schools Are Affiliated With Johan Neyts

Johan Neyts is affiliated with the following schools: University of Antwerp, KU Leuven, Charles University

Johan Neyts's AcademicInfluence.com Rankings

Johan Neyts

Biology

#4439

World Rank

#6614

Historical Rank

Virology

#81

World Rank

#84

Historical Rank

Biochemistry

#590

World Rank

#680

Historical Rank

biology Degrees

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Biology

Why Is Johan Neyts Influential?

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According to Wikipedia, Johan Hendrik Neyts is a Belgian virologist. He is head of The Neyts-lab of Virology, Antiviral Drug and Vaccine Research, which is part of the Laboratory of Virology and Chemotherapy at the Rega Institute for Medical Research, and full professor of virology at the Faculty of Medicine of KU Leuven. During the 2019-2020 coronavirus pandemic, Neyts came to national prominence as an expert on the search for antiviral drugs and vaccines against SARS-CoV-2.

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Johan Neyts's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Angiogenesis: regulators and clinical applications. (2001) (770)
Screening of an FDA-Approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell Culture (2014) (645)
In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine (2004) (600)
Animal models for COVID-19 (2020) (582)
Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms (2020) (427)
α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment (2020) (368)
N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 (2021) (358)
Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug. (2012) (329)
An Orally Bioavailable Antipoxvirus Compound (ST-246) Inhibits Extracellular Virus Formation and Protects Mice from Lethal Orthopoxvirus Challenge (2005) (315)
N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 (2021) (314)
Structure and functionality in flavivirus NS-proteins: Perspectives for drug design (2010) (290)
Favipiravir as a potential countermeasure against neglected and emerging RNA viruses (2018) (288)
The non‐immunosuppressive cyclosporin DEBIO‐025 is a potent inhibitor of hepatitis C virus replication in vitro (2006) (274)
The Predominant Mechanism by Which Ribavirin Exerts Its Antiviral Activity In Vitro against Flaviviruses and Paramyxoviruses Is Mediated by Inhibition of IMP Dehydrogenase (2005) (261)
SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape (2021) (251)
The Viral Polymerase Inhibitor 7-Deaza-2’-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model (2016) (251)
Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties. (2001) (248)
The mannose-specific plant lectins from Cymbidium hybrid and Epipactis helleborine and the (N-acetylglucosamine)n-specific plant lectin from Urtica dioica are potent and selective inhibitors of human immunodeficiency virus and cytomegalovirus replication in vitro. (1992) (239)
Selective inhibitors of picornavirus replication (2008) (235)
HPMPC (cidofovir), PMEA (adefovir) and Related Acyclic Nucleoside Phosphonate Analogues: A Review of their Pharmacology and Clinical Potential in the Treatment of Viral Infections (1997) (234)
Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro (1991) (224)
Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern (2021) (215)
Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine lacks activity (2020) (201)
Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein (2015) (193)
Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral. (2014) (192)
Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages (2020) (189)
DEB025 (Alisporivir) Inhibits Hepatitis C Virus Replication by Preventing a Cyclophilin A Induced Cis-Trans Isomerisation in Domain II of NS5A (2010) (187)
Perspectives for the treatment of infections with Flaviviridae. (2000) (184)
Structure-activity relationship of new anti-hepatitis C virus agents: heterobicycle-coumarin conjugates. (2009) (176)
Broad betacoronavirus neutralization by a stem helix–specific human antibody (2021) (173)
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters (2020) (173)
Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection (2006) (168)
Sofosbuvir Inhibits Hepatitis E Virus Replication In Vitro and Results in an Additive Effect When Combined With Ribavirin. (2016) (168)
Update on hepatitis E virology: Implications for clinical practice. (2016) (168)
Synthesis of new benzimidazole-coumarin conjugates as anti-hepatitis C virus agents. (2008) (168)
Sulfated polymers inhibit the interaction of human cytomegalovirus with cell surface heparan sulfate. (1992) (167)
A mutation in the hepatitis E virus RNA polymerase promotes its replication and associates with ribavirin treatment failure in organ transplant recipients. (2014) (167)
Broad sarbecovirus neutralization by a human monoclonal antibody (2021) (153)
Calcineurin inhibitors stimulate and mycophenolic acid inhibits replication of hepatitis E virus. (2014) (153)
Antiviral drug susceptibility of human herpesvirus 8 (1997) (151)
Antiviral agents active against human herpesviruses HHV‐6, HHV‐7 and HHV‐8 (2001) (151)
SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging (2020) (145)
Combating enterovirus replication: state-of-the-art on antiviral research. (2012) (144)
Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches (2021) (141)
Recommendations for enterovirus diagnostics and characterisation within and beyond Europe. (2018) (140)
Molecular strategies to inhibit the replication of RNA viruses (2008) (133)
The Novel Immunosuppressive Agent Mycophenolate Mofetil Markedly Potentiates the Antiherpesvirus Activities of Acyclovir, Ganciclovir, and Penciclovir In Vitro and In Vivo (1998) (133)
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity (2020) (125)
Ribavirin Inhibits In Vitro Hepatitis E Virus Replication through Depletion of Cellular GTP Pools and Is Moderately Synergistic with Alpha Interferon (2013) (123)
Viral Macro Domains Reverse Protein ADP-Ribosylation (2016) (123)
Heterocyclic rimantadine analogues with antiviral activity. (2003) (120)
A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate (2020) (120)
Debio 025, a Cyclophilin Binding Molecule, Is Highly Efficient in Clearing Hepatitis C Virus (HCV) Replicon-Containing Cells When Used Alone or in Combination with Specifically Targeted Antiviral Therapy for HCV (STAT-C) Inhibitors (2008) (119)
Favipiravir (T-705) inhibits in vitro norovirus replication. (2012) (118)
Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A (2009) (118)
Statins potentiate the in vitro anti‐hepatitis C virus activity of selective hepatitis C virus inhibitors and delay or prevent resistance development (2009) (118)
Spiro[pyrrolidine-2,2'-adamantanes]: synthesis, anti-influenza virus activity and conformational properties. (2003) (117)
Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication (2012) (116)
Ribavirin for the treatment of chronic hepatitis C virus infection: a review of the proposed mechanisms of action. (2011) (115)
Antiviral agents acting as DNA or RNA chain terminators. (2009) (112)
Study of hepatitis E virus infection of genotype 1 and 3 in mice with humanised liver (2016) (108)
Inhibition of Urokinase-Type Plasminogen Activator or Matrix Metalloproteinases Prevents Cardiac Injury and Dysfunction During Viral Myocarditis (2006) (107)
Use of the yellow fever virus vaccine strain 17D for the study of strategies for the treatment of yellow fever virus infections. (1996) (107)
Coumarin-purine ribofuranoside conjugates as new agents against hepatitis C virus. (2011) (106)
Inhibition of Human Immunodeficiency Virus Type 1 Replication in Human Cells by Debio-025, a Novel Cyclophilin Binding Agent (2008) (106)
Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virus. (2012) (106)
Efficacy of (S)‐1‐(3‐hydroxy‐2‐phosphonylmethoxypropyl)cytosine for the treatment of lethal vaccinia virus infections in severe combined immune deficiency (SCID) mice (1993) (103)
Selective inhibition of human cytomegalovirus DNA synthesis by (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG). (1990) (102)
Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2 (2021) (101)
Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines (2019) (101)
The omicron (B.1.1.529) SARS-CoV-2 variant of concern does not readily infect Syrian hamsters (2021) (98)
Poly(I)-Poly(C12U) but Not Ribavirin Prevents Death in a Hamster Model of Nipah Virus Infection (2006) (97)
Bioactive Natural Products Prioritization Using Massive Multi-informational Molecular Networks. (2017) (97)
A robust human norovirus replication model in zebrafish larvae (2019) (96)
Hepatitis E virus mutations associated with ribavirin treatment failure result in altered viral fitness and ribavirin sensitivity. (2016) (95)
A Novel, Broad-Spectrum Inhibitor of Enterovirus Replication That Targets Host Cell Factor Phosphatidylinositol 4-Kinase IIIβ (2013) (95)
Mechanistic Characterization of GS-9190 (Tegobuvir), a Novel Nonnucleoside Inhibitor of Hepatitis C Virus NS5B Polymerase (2011) (94)
The Viral Polymerase Inhibitor 2′-C-Methylcytidine Inhibits Norwalk Virus Replication and Protects against Norovirus-Induced Diarrhea and Mortality in a Mouse Model (2013) (93)
Antiviral activity of a sulphated polysaccharide from the red seaweed Nothogenia fastigiata. (1994) (93)
Synergy of entry inhibitors with direct-acting antivirals uncovers novel combinations for prevention and treatment of hepatitis C (2014) (90)
Prostratin and 12-O-tetradecanoylphorbol 13-acetate are potent and selective inhibitors of Chikungunya virus replication. (2012) (89)
Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus. (2013) (89)
A Novel, Highly Selective Inhibitor of Pestivirus Replication That Targets the Viral RNA-Dependent RNA Polymerase (2006) (89)
Modulation of fibroblast growth factor-2 receptor binding, signaling, and mitogenic activity by heparin-mimicking polysulfonated compounds. (1999) (88)
Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication. (2013) (87)
The microRNA-221/-222 cluster balances the antiviral and inflammatory response in viral myocarditis. (2015) (87)
Extra‐hepatic replication and infection of hepatitis E virus in neuronal‐derived cells (2016) (86)
Antiviral Activity of Bay 41-4109 on Hepatitis B Virus in Humanized Alb-uPA/SCID Mice (2011) (86)
3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against Picornaviruses (2013) (86)
The postbinding activity of scavenger receptor class B type I mediates initiation of hepatitis C virus infection and viral dissemination (2013) (85)
Towards antivirals against chikungunya virus (2015) (85)
The Anti-Yellow Fever Virus Activity of Ribavirin Is Independent of Error-Prone Replication (2006) (85)
Synthesis and antiviral activity evaluation of some new aminoadamantane derivatives. 2. (1996) (85)
Therapeutic potential of nucleoside/nucleotide analogues against poxvirus infections (2004) (84)
The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family (2015) (84)
The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection (2016) (83)
The Crystal Structure of Coxsackievirus B3 RNA-Dependent RNA Polymerase in Complex with Its Protein Primer VPg Confirms the Existence of a Second VPg Binding Site on Picornaviridae Polymerases (2008) (82)
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids (2021) (82)
In vitro susceptibility of six isolates of equine herpesvirus 1 to acyclovir, ganciclovir, cidofovir, adefovir, PMEDAP and foscarnet. (2007) (80)
Comparing infectivity and virulence of emerging SARS-CoV-2 variants in Syrian hamsters (2021) (80)
Sulphated Polymers are Potent and Selective Inhibitors of Various Enveloped Viruses, Including Herpes Simplex Virus, Cytomegalovirus, Vesicular Stomatitis Virus, Respiratory Syncytial Virus, and Toga-, Arena- and Retroviruses (1990) (78)
Selective inhibition of hepatitis B virus replication by RNA interference. (2003) (78)
Novel 1,2,4-triazole and imidazole derivatives of L-ascorbic and imino-ascorbic acid: synthesis, anti-HCV and antitumor activity evaluations. (2012) (78)
The main hepatitis B virus (HBV) mutants resistant to nucleoside analogs are susceptible in vitro to non-nucleoside inhibitors of HBV replication. (2011) (76)
A Derivate of the Antibiotic Doxorubicin Is a Selective Inhibitor of Dengue and Yellow Fever Virus Replication In Vitro (2010) (76)
Mycophenolic acid, an immunosuppressive agent, inhibits HBV replication in vitro (1999) (75)
Flaviviral NS4b, chameleon and jack‐in‐the‐box roles in viral replication and pathogenesis, and a molecular target for antiviral intervention (2015) (75)
Tracking the Evolution of Multiple In Vitro Hepatitis C Virus Replicon Variants under Protease Inhibitor Selection Pressure by 454 Deep Sequencing (2010) (74)
Mutations in the Nonstructural Protein 3A Confer Resistance to the Novel Enterovirus Replication Inhibitor TTP-8307 (2009) (73)
The Thiazolobenzimidazole TBZE-029 Inhibits Enterovirus Replication by Targeting a Short Region Immediately Downstream from Motif C in the Nonstructural Protein 2C (2008) (73)
Zika Virus Replicons for Drug Discovery (2016) (72)
Picornavirus non-structural proteins as targets for new anti-virals with broad activity. (2011) (72)
Antitumor potential of acyclic nucleoside phosphonates. (1999) (71)
Phosphatidylinositol 4-Kinase III Beta Is Essential for Replication of Human Rhinovirus and Its Inhibition Causes a Lethal Phenotype In Vivo (2013) (70)
Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: from anti-pestivirus to anti-hepatitis C virus activity. (2007) (70)
ANTIVIRAL POTENTIAL OF A NEW GENERATION OF ACYCLIC NUCLEOSIDE PHOSPHONATES, THE 6-[2-(PHOSPHONOMETHOXY)ALKOXY]-2,4-DIAMINOPYRIMIDINES (2005) (70)
Selective Serotonin Reuptake Inhibitor Fluoxetine Inhibits Replication of Human Enteroviruses B and D by Targeting Viral Protein 2C (2013) (70)
Antiviral treatment of chronic hepatitis B virus infections: the past, the present and the future (2008) (70)
Particular characteristics of the anti-human cytomegalovirus activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) in vitro. (1991) (69)
A case for developing antiviral drugs against polio. (2008) (69)
Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity (2015) (68)
Synthesis and anti-BVDV activity of acridones as new potential antiviral agents. (2006) (68)
Selective inhibitors of hepatitis C virus replication. (2003) (68)
Antimicrobial, Anthelmintic, and Antiviral Activity of Plants Traditionally Used for Treating Infectious Disease in the Similipal Biosphere Reserve, Odisha, India (2017) (68)
Avian influenza A (H5N1) infection: targets and strategies for chemotherapeutic intervention (2007) (67)
Molnupiravir Inhibits Replication of the Emerging SARS-CoV-2 Variants of Concern in a Hamster Infection Model (2021) (67)
Evaluation of Hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)Propyl]-Adenine, CMX157, as a Potential Treatment for Human Immunodeficiency Virus Type 1 and Hepatitis B Virus Infections (2007) (67)
Interferons, Interferon Inducers, and Interferon-Ribavirin in Treatment of Flavivirus-Induced Encephalitis in Mice (2003) (67)
The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model (2021) (67)
Efficacy of Cidofovir in a Murine Model of Disseminated Progressive Vaccinia (2004) (66)
Hemin potentiates the anti-hepatitis C virus activity of the antimalarial drug artemisinin. (2006) (65)
Efficacy of (S)‐1‐(3‐hydroxy‐2‐phosphonylmethoxypropyl)cytosine and 9‐(1,3‐dihydroxy‐2‐propoxymethyl)guanine for the treatment of murine cytomegalovirus infection in severe combined immunodeficiency mice (1992) (65)
Antiviral strategies to control calicivirus infections (2010) (64)
Hepatitis C virus infection of neuroepithelioma cell lines. (2010) (64)
Jatrophane diterpenes as inhibitors of chikungunya virus replication: structure-activity relationship and discovery of a potent lead. (2014) (63)
The role of phosphatidylinositol 4-kinases and phosphatidylinositol 4-phosphate during viral replication (2012) (63)
Potential use of antiviral agents in polio eradication. (2008) (63)
Genome sequence analysis of Tamana bat virus and its relationship with the genus Flavivirus. (2002) (62)
The Interferon Inducer Ampligen [Poly(I)-Poly(C12U)] Markedly Protects Mice against Coxsackie B3 Virus-Induced Myocarditis (2004) (62)
The antiviral agent cidofovir [(S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl)cytosine] has pronounced activity against nasopharyngeal carcinoma grown in nude mice. (1998) (62)
Drug candidates and model systems in respiratory syncytial virus antiviral drug discovery (2017) (62)
A chemiluminescence detection method of hantaviral antigens in neutralisation assays and inhibitor studies. (2001) (62)
Antiviral Activity of Diterpene Esters on Chikungunya Virus and HIV Replication. (2015) (61)
7‐Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase (1998) (61)
Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase (2017) (60)
ACYCLIC/CARBOCYCLIC GUANOSINE ANALOGUES AS ANTI-HERPESVIRUS AGENTS (2001) (60)
Broad-range inhibition of enterovirus replication by OSW-1, a natural compound targeting OSBP. (2015) (60)
Depletion of GTP pool is not the predominant mechanism by which ribavirin exerts its antiviral effect on Lassa virus. (2011) (59)
Ribavirin Antagonizes the In Vitro Anti-Hepatitis C Virus Activity of 2′-C-Methylcytidine, the Active Component of Valopicitabine (2006) (59)
Hydrogels containing monocaprin prevent intravaginal and intracutaneous infections with HSV‐2 in mice: Impact on the search for vaginal microbicides (2000) (58)
In Vitro and In Vivo Inhibition of Murine Gamma Herpesvirus 68 Replication by Selected Antiviral Agents (1998) (58)
Hepatitis B virus replication causes oxidative stress in HepAD38 liver cells (2006) (58)
Broad Antiviral Activity of Carbohydrate-Binding Agents against the Four Serotypes of Dengue Virus in Monocyte-Derived Dendritic Cells (2011) (58)
A novel kindred with inherited STAT2 deficiency and severe viral illness. (2017) (57)
Genomics and structure/function studies of Rhabdoviridae proteins involved in replication and transcription. (2010) (57)
Antiviral Treatment of Chronic Hepatitis B Virus (HBV) Infections† (2010) (57)
Antiviral activity of carbohydrate-binding agents and the role of DC-SIGN in dengue virus infection. (2009) (56)
Inhibition of norovirus replication by the nucleoside analogue 2'-C-methylcytidine. (2012) (56)
Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains (2021) (56)
The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern (2021) (56)
Antiviral Activity of Triazine Analogues of 1-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine (Cidofovir) and Related Compounds (2007) (56)
A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction (2021) (56)
Discovery of novel arylethynyltriazole ribonucleosides with selective and effective antiviral and antiproliferative activity. (2009) (56)
The Capsid Binder Vapendavir and the Novel Protease Inhibitor SG85 Inhibit Enterovirus 71 Replication (2014) (56)
Norovirus: Targets and tools in antiviral drug discovery (2014) (56)
Complete genome sequence, taxonomic assignment, and comparative analysis of the untranslated regions of the Modoc virus, a flavivirus with no known vector. (2002) (55)
Synthesis and antiviral activity of an imidazo[1,2-a]pyrrolo[2,3-c]pyridine series against the bovine viral diarrhea virus. (2010) (55)
Identification of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones as novel inhibitors of Chikungunya virus replication. (2014) (54)
Stem cell-derived hepatocytes: A novel model for hepatitis E virus replication. (2016) (54)
Comparative Study of the Genetic Barriers and Pathways towards Resistance of Selective Inhibitors of Hepatitis C Virus Replication (2011) (54)
Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses (2022) (54)
Medical treatment options for COVID-19 (2020) (53)
Inhibition of human norovirus by a viral polymerase inhibitor in the B cell culture system and in the mouse model. (2016) (53)
Towards the design of combination therapy for the treatment of enterovirus infections. (2011) (52)
Novel 3-(2-adamantyl)pyrrolidines with potent activity against influenza A virus-identification of aminoadamantane derivatives bearing two pharmacophoric amine groups. (2001) (51)
2'-C-methylcytidine as a potent and selective inhibitor of the replication of foot-and-mouth disease virus. (2007) (51)
The future of antivirals: broad-spectrum inhibitors (2015) (50)
Phosphorylation of aciclovir, ganciclovir, penciclovir and S2242 by the cytomegalovirus UL97 protein: a quantitative analysis using recombinant vaccinia viruses. (1997) (50)
Coumarins hinged directly on benzimidazoles and their ribofuranosides to inhibit hepatitis C virus. (2013) (50)
Imprinted antibody responses against SARS-CoV-2 Omicron sublineages (2022) (50)
Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity. (2007) (50)
Inhibition of subgenomic hepatitis C virus RNA replication by acridone derivatives: identification of an NS3 helicase inhibitor. (2009) (49)
Inhibitory Effects of Novel Nucleoside and Nucleotide Analogues on Epstein—Barr Virus Replication (1998) (49)
Evaluation of Hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)Propyl]- Adenine, CMX157, as a Potential Treatment for Human Immunodeficiency Virus Type 1 and Hepatitis B Virus Infections (2007) (49)
Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry (2021) (49)
Suboptimal Response to Adefovir Dipivoxil Therapy for Chronic Hepatitis B in Nucleoside-Naive Patients is not due to Pre-Existing Drug-Resistant Mutants (2008) (49)
The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir (2022) (48)
A novel model for the study of the therapy of flavivirus infections using the Modoc virus. (2001) (48)
Broad-Spectrum Antiviral Activity and Mechanism of Antiviral Action of the Fluoroquinolone Derivative K-12 (1998) (48)
Clinical effect of cidofovir and a diet supplemented with Spirulina platensis in white spot syndrome virus (WSSV) infected specific pathogen-free Litopenaeus vannamei juveniles (2006) (48)
Tigliane diterpenes from Croton mauritianus as inhibitors of chikungunya virus replication. (2014) (48)
Discovery of a novel HCV helicase inhibitor by a de novo drug design approach. (2008) (48)
Arylethynyltriazole acyclonucleosides inhibit hepatitis C virus replication. (2008) (47)
Polyanion inhibitors of HIV and other viruses. 7. Polyanionic compounds and polyzwitterionic compounds derived from cyclodextrins as inhibitors of HIV transmission. (1998) (47)
Synthesis and primary antiviral activity evaluation of 3-hydrazono-5-nitro-2-indolinone derivatives (2005) (47)
Antiviral strategies for hepatitis E virus (2013) (47)
Anti-enterovirus activity and structure-activity relationship of a series of 2,6-dihalophenyl-substituted 1H,3H-thiazolo[3,4-a]benzimidazoles. (2007) (46)
Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine. (2006) (46)
Differential antiviral activity of derivatized dextrans. (1995) (46)
Towards antiviral therapies for treating dengue virus infections. (2016) (46)
Complete genome sequence of Montana Myotis leukoencephalitis virus, phylogenetic analysis and comparative study of the 3' untranslated region of flaviviruses with no known vector. (2002) (46)
Trigocherrierin A, a Potent Inhibitor of Chikungunya Virus Replication (2014) (46)
Mycophenolate mofetil strongly potentiates the anti-herpesvirus activity of acyclovir. (1998) (46)
Substituted imidazopyridines as potent inhibitors of HCV replication☆ (2009) (46)
STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters (2020) (45)
Inhibition of fibroblast growth factor-2-induced vascular tumor formation by the acyclic nucleoside phosphonate cidofovir. (2001) (45)
The Enterovirus Protease Inhibitor Rupintrivir Exerts Cross-Genotypic Anti-Norovirus Activity and Clears Cells from the Norovirus Replicon (2014) (45)
Differential Effects of the Putative GBF1 Inhibitors Golgicide A and AG1478 on Enterovirus Replication (2010) (45)
Comparative In Vitro Anti-Hepatitis C Virus Activities of a Selected Series of Polymerase, Protease, and Helicase Inhibitors (2008) (45)
Evaluation of antiviral activity against human herpesvirus 8 (HHV-8) and Epstein-Barr virus (EBV) by a quantitative real-time PCR assay. (2004) (45)
Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68 (2015) (44)
Straightforward synthesis of triazoloacyclonucleotide phosphonates as potential HCV inhibitors. (2010) (44)
Potent inhibition of hemangioma formation in rats by the acyclic nucleoside phosphonate analogue cidofovir. (1998) (44)
Therapy and short-term prophylaxis of poxvirus infections: historical background and perspectives. (2003) (44)
The Imidazopyrrolopyridine Analogue AG110 Is a Novel, Highly Selective Inhibitor of Pestiviruses That Targets the Viral RNA-Dependent RNA Polymerase at a Hot Spot for Inhibition of Viral Replication (2007) (43)
The HCV Non-Nucleoside Inhibitor Tegobuvir Utilizes a Novel Mechanism of Action to Inhibit NS5B Polymerase Function (2012) (43)
Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen (2021) (43)
The phosphoramidate ProTide approach greatly enhances the activity of beta-2'-C-methylguanosine against hepatitis C virus. (2009) (43)
An Analogue of the Antibiotic Teicoplanin Prevents Flavivirus Entry In Vitro (2012) (43)
A novel animal model for hemangiomas: inhibition of hemangioma development by the angiogenesis inhibitor TNP-470. (1999) (43)
The N-7-substituted acyclic nucleoside analog 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine is a potent and selective inhibitor of herpesvirus replication (1994) (43)
Effect of 5-Iodo-2′-Deoxyuridine on Vaccinia Virus (Orthopoxvirus) Infections in Mice (2002) (43)
Kobophenol A Inhibits Binding of Host ACE2 Receptor with Spike RBD Domain of SARS-CoV-2, a Lead Compound for Blocking COVID-19 (2021) (42)
In Vitro Activity of 2,4-Diamino-6-[2-(Phosphonomethoxy)Ethoxy]-Pyrimidine against Multidrug-Resistant Hepatitis B Virus Mutants (2007) (42)
Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases. (2015) (42)
Novel Acyclic Nucleoside Phosphonate Analogues with Potent Anti-Hepatitis B Virus Activities (2005) (42)
Molecular Chaperone Hsp90 Is a Therapeutic Target for Noroviruses (2015) (42)
Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry (2022) (41)
Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients (2020) (41)
Are the 2-Isomers of the Drug Rimantadine Active Anti-Influenza a Agents? (2003) (41)
Efficacy of 2-Amino-7-(1,3-Dihydroxy-2-Propoxymethyl)Purine for Treatment of Vaccinia Virus (Orthopoxvirus) Infections in Mice (2001) (41)
In vitro and in vivo inhibition of ortho- and paramyxovirus infections by a new class of sulfonic acid polymers interacting with virus-cell binding and/or fusion (1994) (41)
Antiviral Activity of Favipiravir (T-705) against a Broad Range of Paramyxoviruses In Vitro and against Human Metapneumovirus in Hamsters (2016) (41)
Antiviral activity of [1,2,3]triazolo[4,5‐d]pyrimidin‐7(6H)‐ones against chikungunya virus targeting the viral capping nsP1 (2017) (41)
Intervention strategies for emerging viruses: use of antivirals (2013) (41)
Preclinical Characterization of Naturally Occurring Polyketide Cyclophilin Inhibitors from the Sanglifehrin Family (2011) (40)
A prospect on the use of antiviral drugs to control local outbreaks of COVID-19 (2020) (40)
2-Chloro-3-pyridin-3-yl-5,6,7,8-tetrahydroindolizine-1-carboxamide (CMV423), a new lead compound for the treatment of human cytomegalovirus infections. (2002) (40)
Replication of the Zika virus in different iPSC-derived neuronal cells and implications to assess efficacy of antivirals. (2017) (40)
Synthesis and evaluation of imidazole-4,5- and pyrazine-2,3-dicarboxamides targeting dengue and yellow fever virus (2014) (40)
Inhibitory activity of S-adenosylhomocysteine hydrolase inhibitors against human cytomegalovirus replication. (1993) (40)
A Single-Dose Live-Attenuated Zika Virus Vaccine with Controlled Infection Rounds that Protects against Vertical Transmission. (2018) (39)
Mechanism of action of acyclic nucleoside phosphonates against herpes virus replication. (1994) (39)
Artemisinin Analogues as Potent Inhibitors of In Vitro Hepatitis C Virus Replication (2013) (39)
Structure-activity relationship study of arbidol derivatives as inhibitors of chikungunya virus replication. (2014) (38)
Use of Cotton Rats to Evaluate the Efficacy of Antivirals in Treatment of Measles Virus Infections (2000) (38)
The sulfonic acid polymers PAMPS [poly(2-acrylamido-2-methyl-1-propanesulfonic acid)] and related analogues are highly potent inhibitors of angiogenesis. (1997) (38)
Identification of a series of compounds with potent antiviral activity for the treatment of enterovirus infections. (2013) (38)
Poly(Hydroxy)Carboxylates as Selective Inhibitors of Cytomegalovirus and Herpes Simplex Virus Replication (1992) (37)
Advances and gaps in SARS-CoV-2 infection models (2022) (37)
Uncovering oxysterol‐binding protein (OSBP) as a target of the anti‐enteroviral compound TTP‐8307 (2017) (37)
Binding of Glutathione to Enterovirus Capsids Is Essential for Virion Morphogenesis (2014) (36)
Antibacterial, Antifungal, Antiviral, and Anthelmintic Activities of Medicinal Plants of Nepal Selected Based on Ethnobotanical Evidence (2020) (36)
3-Biphenylimidazo[1,2-a]pyridines or [1,2-b]pyridazines and analogues, novel Flaviviridae inhibitors. (2013) (36)
Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication. (2013) (36)
Identification of inhibitors of SARS-CoV-2 3CL-Pro enzymatic activity using a small molecule in-vitro repurposing screen (2020) (36)
Ribavirin and mycophenolic acid potentiate the activity of guanine- and diaminopurine-based nucleoside analogues against hepatitis B virus. (2000) (36)
Chikungunya virus infections: time to act, time to treat. (2017) (36)
Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase. (2012) (36)
Hepatitis C virus-specific directly acting antiviral drugs. (2013) (36)
Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata. (2015) (35)
CCL20, a direct‐acting pro‐angiogenic chemokine induced by hepatitis C virus (HCV): Potential role in HCV‐related liver cancer (2018) (35)
Hepatitis E virus replication and interferon responses in human placental cells (2018) (35)
Biosafety standards for working with Crimean-Congo hemorrhagic fever virus. (2016) (35)
A yellow fever–Zika chimeric virus vaccine candidate protects against Zika infection and congenital malformations in mice (2018) (35)
The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors. (2014) (35)
A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses (2019) (35)
Antiviral Therapy for Hepatitis C Virus: Beyond the Standard of Care (2010) (34)
Discovery of Indole Derivatives as Novel and Potent Dengue Virus Inhibitors. (2018) (34)
New Pyrazolobenzothiazine Derivatives as Hepatitis C Virus NS5B Polymerase Palm Site I Inhibitors (2014) (34)
Benzouracil-coumarin-arene conjugates as inhibiting agents for chikungunya virus. (2015) (33)
Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors. (2010) (33)
Molecular Biology and Inhibitors of Hepatitis A Virus (2013) (32)
Growth kinetics of SARS-coronavirus in Vero E6 cells (2005) (32)
Imidazo[4,5-c]pyridines inhibit the in vitro replication of the classical swine fever virus and target the viral polymerase. (2008) (32)
Prophylactic treatment with the nucleoside analogue 2'-C-methylcytidine completely prevents transmission of norovirus. (2015) (32)
Influence of an additional 2-amino substituent of the 1-aminoethyl pharmacophore group on the potency of rimantadine against influenza virus A. (2007) (31)
In vivo antiherpesvirus activity of N-7-substituted acyclic nucleoside analog 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine (1995) (31)
Assessing medicinal plants traditionally used in the Chirang Reserve Forest, Northeast India for antimicrobial activity. (2018) (31)
Crucial role of the N-glycans on the viral E-envelope glycoprotein in DC-SIGN-mediated dengue virus infection. (2012) (31)
Intracellular metabolism of the N7-substituted acyclic nucleoside analog 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine, a potent inhibitor of herpesvirus replication. (1998) (31)
9-Arylpurines as a novel class of enterovirus inhibitors. (2010) (30)
Mycophenolate mofetil inhibits the development of Coxsackie B3-virus-induced myocarditis in mice (2003) (30)
Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2 (2021) (30)
Comparisons of the influenza virus A M2 channel binding affinities, anti-influenza virus potencies and NMDA antagonistic activities of 2-alkyl-2-aminoadamantanes and analogues. (2008) (30)
Effect of polyanionic compounds on intracutaneous and intravaginal herpesvirus infection in mice: impact on the search for vaginal microbicides with anti-HIV activity. (1995) (30)
Infection of SCID mice with Montana Myotis leukoencephalitis virus as a model for flavivirus encephalitis. (2002) (30)
Potent inhibition of hemangiosarcoma development in mice by cidofovir (2001) (29)
Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells (1998) (29)
The acyclic nucleoside phosphonate analogues, adefovir, tenofovir and PMEDAP, efficiently eliminate banana streak virus from banana (Musa spp.). (2003) (29)
Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogues Provides Additional Evidence for a PKC-Independent Pathway. (2016) (29)
Antiviral treatment efficiently inhibits chikungunya virus infection in the joints of mice during the acute but not during the chronic phase of the infection. (2018) (29)
Antiviral activity of anti-cytomegalovirus agents (HPMPC, HPMPA) assessed by a flow cytometric method and DNA hybridization technique. (1991) (29)
Detection of immediate early, early and late antigens of human cytomegalovirus by flow cytometry. (1989) (29)
Isolation of Premyrsinane, Myrsinane, and Tigliane Diterpenoids from Euphorbia pithyusa Using a Chikungunya Virus Cell-Based Assay and Analogue Annotation by Molecular Networking. (2017) (29)
Application of the phosphoramidate ProTide approach to the antiviral drug ribavirin (2008) (29)
A robust SARS-CoV-2 replication model in primary human epithelial cells at the air liquid interface to assess antiviral agents (2021) (29)
In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses (2015) (29)
Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds. (2007) (29)
Viral load quantitation of SARS-coronavirus RNA using a one-step real-time RT-PCR (2005) (28)
A novel benzonitrile analogue inhibits rhinovirus replication. (2014) (28)
LC-MS²-Based dereplication of Euphorbia extracts with anti-Chikungunya virus activity. (2015) (28)
Antiplasmodial, anti-chikungunya virus and antioxidant activities of 64 endemic plants from the Mascarene Islands. (2018) (28)
Acute Encephalitis, a Poliomyelitis‐like Syndrome and Neurological Sequelae in a Hamster Model for Flavivirus Infections (2003) (28)
Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors. (2015) (28)
Design, synthesis, optimization and antiviral activity of a class of hybrid dengue virus E protein inhibitors. (2015) (28)
ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies (2022) (28)
Synthetic strategy and antiviral evaluation of diamide containing heterocycles targeting dengue and yellow fever virus (2016) (27)
A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate (2020) (27)
Efficacy of oral 9‐(2‐phosphonylmethoxyethyl)‐2,6‐diaminopurine (PMEDAP) in the treatment of retrovirus and cytomegalovirus infections in mice (1993) (27)
Rodent models for the study of therapy against flavivirus infections. (2004) (27)
Proof of concept for the reduction of classical swine fever infection in pigs by a novel viral polymerase inhibitor. (2009) (27)
Antiviral treatment of SARS-CoV-2-infected hamsters reveals a weak effect of favipiravir and a complete lack of effect for hydroxychloroquine (2020) (27)
Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine. (2008) (27)
Exchanging the Yellow Fever Virus Envelope Proteins with Modoc Virus prM and E Proteins Results in a Chimeric Virus That Is Neuroinvasive in SCID Mice (2004) (27)
Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry (2020) (26)
A highly potent antibody effective against SARS-CoV-2 variants of concern (2021) (26)
A rat model for hepatitis E virus (2016) (26)
A novel method for high-throughput screening to quantify antiviral activity against viruses that induce limited CPE (2012) (26)
Antiviral Strategies Against Chikungunya Virus (2015) (26)
Replication of not-known-vector flaviviruses in mosquito cells is restricted by intracellular host factors rather than by the viral envelope proteins. (2010) (26)
Infections with flaviviridae. (1999) (26)
Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors. (2006) (26)
The Antiherpesvirus Activity of H2G [(R)-9-[4-Hydroxy-2-(Hydroxymethyl)Butyl]Guanine] Is Markedly Enhanced by the Novel Immunosuppressive Agent Mycophenolate Mofetil (1998) (26)
In search of flavivirus inhibitors: evaluation of different tritylated nucleoside analogues. (2013) (26)
An affinity-enhanced, broadly neutralizing heavy chain–only antibody protects against SARS-CoV-2 infection in animal models (2021) (25)
Interferon lambda (IFN‐&lgr;) efficiently blocks norovirus transmission in a mouse model (2018) (25)
Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: further optimization of anti-hepatitis C virus activity. (2007) (25)
Discovery of novel multi-target indole-based derivatives as potent and selective inhibitors of chikungunya virus replication. (2017) (25)
The VIZIER project: Preparedness against pathogenic RNA viruses (2007) (25)
Favipiravir inhibits in vitro Usutu virus replication and delays disease progression in an infection model in mice. (2018) (25)
Toward antiviral therapy/prophylaxis for rhinovirus‐induced exacerbations of chronic obstructive pulmonary disease: challenges, opportunities, and strategies (2015) (25)
A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase. (2009) (25)
In vitro activity of itraconazole against SARS‐CoV‐2 (2020) (25)
Bioengineering and Semisynthesis of an Optimized Cyclophilin Inhibitor for Treatment of Chronic Viral Infection (2015) (25)
ZikaPLAN: Zika Preparedness Latin American Network (2017) (25)
3',5'Di-O-trityluridine inhibits in vitro flavivirus replication. (2013) (25)
Studies of Antiviral Activity and Cytotoxicity of Wrightia tinctoria and Morinda citrifolia (2009) (24)
Synthesis and antiviral evaluation of cis-substituted cyclohexenyl and cyclohexanyl nucleosides. (2005) (24)
Synthesis, conformational characteristics and anti-influenza virus A activity of some 2-adamantylsubstituted azacycles. (2006) (24)
Sulphated and Sulphonated Polymers Inhibit the Initial Interaction of Hepatitis B Virus with Hepatocytes (2002) (24)
Modification of the length and structure of the linker of N(6)-benzyladenosine modulates its selective antiviral activity against enterovirus 71. (2016) (24)
Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus-A71 capsid (2019) (24)
Synthesis of 5-aryltriazole ribonucleosides via Suzuki coupling and promoted by microwave irradiation (2006) (24)
Aminopurine and aminoquinazoline scaffolds for development of potential dengue virus inhibitors. (2017) (23)
ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model (2021) (23)
In vitro Activity of a Novel Series of Polyoxosilicotungstates against Human Myxo-, Herpes- and Retroviruses (1993) (23)
Synthesis and Structure-Activity Relationships of Imidazole-Coumarin Conjugates against Hepatitis C Virus (2016) (23)
Chemical modification of the plant isoprenoid cytokinin N(6)-isopentenyladenosine yields a selective inhibitor of human enterovirus 71 replication. (2015) (23)
Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication. (2016) (23)
Conservation of the pentanucleotide motif at the top of the yellow fever virus 17D 3' stem-loop structure is not required for replication. (2007) (23)
A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication. (2017) (22)
Inhibition of hepatitis C virus replication by semi-synthetic derivatives of glycopeptide antibiotics (2010) (22)
The reduction of CSFV transmission to untreated pigs by the pestivirus inhibitor BPIP: a proof of concept. (2009) (22)
Prospects for antiviral therapy. (2003) (22)
Protein kinases C as potential host targets for the inhibition of chikungunya virus replication (2017) (22)
Pan-viral protection against arboviruses by activating skin macrophages at the inoculation site (2020) (22)
Comparative infectivity and pathogenesis of emerging SARS-CoV-2 variants in Syrian hamsters (2021) (22)
Differentiated umbilical cord matrix stem cells as a new in vitro model to study early events during hepatitis B virus infection (2013) (22)
In search of Flavivirus inhibitors part 2: tritylated, diphenylmethylated and other alkylated nucleoside analogues. (2014) (22)
Clinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host (2020) (22)
A Chimeric Japanese Encephalitis Vaccine Protects against Lethal Yellow Fever Virus Infection without Inducing Neutralizing Antibodies (2019) (22)
In Vitro Antiviral Activity of some Novel Isatin Derivatives against HCV and SARS-CoV Viruses (2008) (21)
Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step. (2009) (21)
IN VIVO ANTIRETROVIRAL EFFICACY OF ORAL BIS(POM)-PMEA, THE BIS(PIVALOYLOXYMETHYL)PRODRUG OF 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE (PMEA) (1995) (21)
SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors. (2011) (21)
Antiviral activity of ganciclovir elaidic acid ester against herpesviruses. (2000) (21)
Synthesis and antiviral evaluation of cyclic and acyclic 2-methyl-3-hydroxy-4-pyridinone nucleoside derivatives. (2006) (20)
HCV‐induced EGFR‐ERK signaling promotes a pro‐inflammatory and pro‐angiogenic signature contributing to liver cancer pathogenesis (2018) (20)
Antibody-dependent enhancement of dengue virus infection is inhibited by SA-17, a doxorubicin derivative. (2013) (20)
Cu-mediated Selective N-arylation of Aminotriazole Acyclonucleosides (2009) (20)
Identification of a novel resistance mutation for benzimidazole inhibitors of the HCV RNA-dependent RNA polymerase. (2012) (20)
Inhibition of coxsackie B3 virus induced myocarditis in mice by 2‐(3,4‐dichlorophenoxy)‐5‐nitrobenzonitrile (2004) (20)
Synthesis and in vitro antiviral evaluation of 4-substituted 3,4-dihydropyrimidinones (2016) (20)
9-Norbornyl-6-chloropurine (NCP) induces cell death through GSH depletion-associated ER stress and mitochondrial dysfunction. (2016) (20)
Imprinted antibody responses against SARS-CoV-2 Omicron sublineages (2022) (19)
A rapid and convenient variant of fusion-PCR to construct chimeric flaviviruses. (2003) (19)
Reverse engineering synthetic antiviral amyloids (2020) (19)
A Single Nucleoside Viral Polymerase Inhibitor Against Norovirus, Rotavirus, and Sapovirus-Induced Diarrhea (2018) (19)
Proof of concept for the inhibition of foot-and-mouth disease virus replication by the anti-viral drug 2'-C-methylcytidine in severe combined immunodeficient mice. (2014) (19)
New 1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides inhibit hepatitis C virus replication via suppression of cyclooxygenase-2. (2015) (19)
Substituted 2,6-bis(benzimidazol-2-yl)pyridines: a novel chemical class of pestivirus inhibitors that targets a hot spot for inhibition of pestivirus replication in the RNA-dependent RNA polymerase. (2014) (19)
The potential of antiviral agents to control classical swine fever: a modelling study. (2013) (18)
Ribavirin and mycophenolic acid markedly potentiate the anti-hepatitis B virus activity of entecavir. (2007) (18)
Highly potent and selective inhibition of bovine viral diarrhea virus replication by γ-carboline derivatives. (2010) (18)
Structure-Based Drug Design of Potent Pyrazole Derivatives against Rhinovirus Replication. (2018) (18)
Classical swine fever outbreak containment using antiviral supplementation: a potential alternative to emergency vaccination and stamping-out. (2012) (18)
Broad spectrum anti-coronavirus activity of a series of anti-malaria quinoline analogues (2021) (18)
Cutthroat trout virus as a surrogate in vitro infection model for testing inhibitors of hepatitis E virus replication. (2013) (18)
Targeting the Viral Polymerase of Diarrhea-Causing Viruses as a Strategy to Develop a Single Broad-Spectrum Antiviral Therapy (2019) (18)
Reaching beyond HIV/HCV: nelfinavir as a potential starting point for broad-spectrum protease inhibitors against dengue and chikungunya virus (2015) (18)
Structural basis for broad sarbecovirus neutralization by a human monoclonal antibody (2021) (18)
The Enterovirus 3C Protease Inhibitor SG85 Efficiently Blocks Rhinovirus Replication and Is Not Cross-Resistant with Rupintrivir (2015) (17)
Assessing the Efficacy of Cidofovir against Herpesvirus-Induced Genital Lesions in Goats Using Different Therapeutic Regimens (2008) (17)
Norovirus genetic diversity and evolution: implications for antiviral therapy. (2016) (17)
Efficient synthesis and anti-enteroviral activity of 9-arylpurines. (2012) (17)
Sangamides, a new class of cyclophilin-inhibiting host-targeted antivirals for treatment of HCV infection (2012) (17)
The immunosuppressive agent mycophenolate mofetil markedly potentiates the activity of lobucavir [1R(1alpha,2beta,3alpha)]-9-[2,3-bis(hydroxymethyl)cyclobutyl]guanine against different herpes viruses. (1999) (17)
88 PARTICULAR IN VITRO ANTI-HCV ACTIVITIES AND RESISTANCE PROFILE OF THE CYCLOPHILIN INHIBITOR DEBIO 025 (2009) (17)
Anti-herpesvirus activity of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)-cycloprop-1'-yl]methyl] x guanine (A-5021) in vitro and in vivo. (2001) (17)
Extra-Hepatic Replication and Infection of Hepatitis E Virus in Neuronal-Derived Cells (2016) (17)
Simple and inexpensive three-step rapid amplification of cDNA 5′ ends using 5′ phosphorylated primers (2013) (17)
Norbornane as the novel pseudoglycone moiety in nucleosides (2009) (17)
Differential antiviral activities of respiratory syncytial virus (RSV) inhibitors in human airway epithelium (2018) (17)
Inhibitory Effects of Polycations on the Replication of Enveloped Viruses (HIV, HSV, CMV, RSV, Influenza A Virus and Togaviruses) in vitro (1991) (17)
Cidofovir is effective against caprine herpesvirus 1 infection in goats. (2007) (17)
Polyanion inhibitors of human immunodeficiency virus and other viruses. Part 2. Polymerized anionic surfactants derived from amino acids and dipeptides. (1996) (16)
Sensitive, reproducible and convenient fluorometric assay for the in vitro evaluation of anti-cytomegalovirus agents. (1991) (16)
New class of early‐stage enterovirus inhibitors with a novel mechanism of action (2017) (16)
A chimeric yellow fever-Zika virus vaccine candidate fully protects against yellow fever virus infection in mice (2020) (16)
In vitro selection and characterization of HCV replicons resistant to multiple non-nucleoside polymerase inhibitors. (2012) (16)
Infection of zebrafish larvae with human norovirus and evaluation of the in vivo efficacy of small-molecule inhibitors (2021) (16)
A human antibody that broadly neutralizes betacoronaviruses protects against SARS-CoV-2 by blocking the fusion machinery (2021) (16)
Limited evolution of the yellow fever virus 17d in a mouse infection model (2019) (16)
Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents. (2010) (16)
Alkyne-Azide Click Chemistry Mediated Carbanucleosides Synthesis (2007) (16)
Structure Elucidation of Coxsackievirus A16 in Complex with GPP3 Informs a Systematic Review of Highly Potent Capsid Binders to Enteroviruses (2015) (16)
Antiviral Compounds from Codiaeum peltatum Targeted by a Multi-informative Molecular Networks Approach. (2019) (16)
Inflammatory rather than infectious insults play a role in exocrine tissue damage in a mouse model for coxsackievirus B4‐induced pancreatitis (2009) (16)
Increased gelatinase B/matrix metalloproteinase 9 (MMP-9) activity in a murine model of acute coxsackievirus B4-induced pancreatitis. (2008) (16)
Norbornane-based nucleoside and nucleotide analogues locked in North conformation. (2015) (16)
Human Herpesvirus 8 Gene Encodes a Functional Thymidylate Synthase (2002) (16)
Mechanistic characterization of GS-9190, a novel non-nucleoside inhibitor of HCV NS5B polymerase with potent antiviral activity and a unique mechanism of action (2007) (15)
Deletion of the vaccinia virus F13L gene results in a highly attenuated virus that mounts a protective immune response against subsequent vaccinia virus challenge. (2012) (15)
In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase. (2017) (15)
Open Science Discovery of Potent Non-Covalent SARS-CoV-2 Main Protease Inhibitors (2023) (15)
Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)-cytosine and 9-(1,3-dihydroxy-2-propoxymethyl)-guanine in the treatment of intracerebral murine cytomegalovirus infections in immunocompetent and immunodeficient mice (1993) (15)
Inhibition of the Replication of Different Strains of Chikungunya Virus by 3-Aryl-[1,2,3]triazolo[4,5- d]pyrimidin-7(6 H)-ones. (2018) (15)
Optimization of a Class of Tryptophan Dendrimers That Inhibit HIV Replication Leads to a Selective, Specific, and Low-Nanomolar Inhibitor of Clinical Isolates of Enterovirus A71 (2016) (15)
Hydroxyurea Potentiates the Antiherpesvirus Activities of Purine and Pyrimidine Nucleoside and Nucleoside Phosphonate Analogs (1999) (15)
Simplified Bryostatin Analogues Protect Cells from Chikungunya Virus-Induced Cell Death (2016) (15)
Human stem cell-derived hepatocyte-like cells support Zika virus replication and provide a relevant model to assess the efficacy of potential antivirals (2018) (15)
Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys (2022) (15)
Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis (2017) (15)
Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases (2014) (15)
Treatment with a Nucleoside Polymerase Inhibitor Reduces Shedding of Murine Norovirus in Stool to Undetectable Levels without Emergence of Drug-Resistant Variants (2015) (14)
Carrier-mediated delivery improves the efficacy of 9-(2-phosphonylmethoxyethyl)adenine against hepatitis B virus. (2001) (14)
ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas (2019) (14)
Diketo acids inhibit the cap-snatching endonuclease of several Bunyavirales. (2020) (14)
Rational modifications on a benzylidene-acrylohydrazide antiviral scaffold, synthesis and evaluation of bioactivity against Chikungunya virus. (2018) (14)
In vitro Activity of Polyhydroxycarboxylates against Herpesviruses and Hiv (2001) (14)
Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C (2020) (14)
Rapid and convenient assays to assess potential inhibitory activity on in vitro hepatitis A replication. (2013) (14)
Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication (2020) (14)
Structure‐activity relationship studies on a Trp dendrimer with dual activities against HIV and enterovirus A71. Modifications on the amino acid (2017) (14)
Calcineurin as a possible new target for treatment of Parkinson's disease. (1994) (14)
Discovery of novel furo[2,3‐d]pyrimidin‐2‐one–1,3,4‐oxadiazole hybrid derivatives as dual antiviral and anticancer agents that induce apoptosis (2021) (14)
Identification of TMEM106B as proviral host factor for SARS-CoV-2 (2020) (13)
Are statins a viable option for the treatment of infections with the hepatitis C virus? (2014) (13)
Identification of fukinolic acid from Cimicifuga heracleifolia and its derivatives as novel antiviral compounds against enterovirus A71 infection. (2019) (13)
A SCAFFOLD SIMPLIFICATION STRATEGY LEADS TO A NOVEL GENERATION OF DUAL HUMAN IMMUNODEFICIENCY VIRUS AND ENTEROVIRUS-A71 ENTRY INHIBITORS. (2019) (13)
Design, synthesis and evaluation against Chikungunya virus of novel small-molecule antiviral agents. (2018) (13)
Post-exposure antiviral treatment of norovirus infections effectively protects against diarrhea and reduces virus shedding in the stool in a mortality mouse model. (2016) (13)
Bicyclic and Tricyclic "Expanded" Nucleobase Analogues of Sofosbuvir: New Scaffolds for Hepatitis C Therapies. (2015) (13)
Synthesis, biological activity and structure-activity relationship of 4,5-dimethoxybenzene derivatives inhibitor of rhinovirus 14 infection. (2014) (13)
Tonantzitlolones from Stillingia lineata ssp. lineata as potential inhibitors of chikungunya virus (2015) (13)
Pyrimethamine inhibits rabies virus replication in vitro (2019) (13)
New neplanocin analogues. VIII. Synthesis and biological activity of 6'-C-ethyl, -ethenyl, and -ethynyl derivatives of neplanocin A. (1997) (13)
Fluorination of Naturally Occurring N6-Benzyladenosine Remarkably Increased Its Antiviral Activity and Selectivity (2017) (12)
H1PVAT is a novel and potent early-stage inhibitor of poliovirus replication that targets VP1. (2014) (12)
Synthesis and anti-CVB 3 evaluation of substituted 5-nitro-2-phenoxybenzonitriles. (2008) (12)
9-[2-(R)-(Phosphonomethoxy)propyl]-2,6-diaminopurine (R)-PMPDAP and its prodrugs: Optimized preparation, including identification of by-products formed, and antiviral evaluation in vitro (2013) (12)
Laboratory validation of a lateral flow device for the detection of CyHV-3 antigens in gill swabs. (2013) (12)
Design, Synthesis and Discovery of N,N’‐Carbazoyl‐aryl‐urea Inhibitors of Zika NS5 Methyltransferase and Virus Replication (2019) (12)
The cyclophilin inhibitor Debio-025 is a potent inhibitor of hepatitis C virus replication in vitro with a unique resistance profile (2006) (12)
Potent Inhibition of Genital Herpesvirus Infection in Goats by Cidofovir (2007) (12)
Synthesis of Ester Prodrugs of 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as Anti-Poxvirus Agents (2010) (12)
Structurally Diverse Diterpenoids from Sandwithia guyanensis. (2018) (12)
Replication capacity of minority variants in viral populations can affect the assessment of resistance in HCV chimeric replicon phenotyping assays. (2012) (12)
S-aryltriazole acyclonucleosides: synthesis and biological evaluation against hepatitis C virus. (2010) (12)
Itraconazole for COVID-19: preclinical studies and a proof-of-concept randomized clinical trial (2021) (12)
New HSV-1 Anti-Viral 1′-Homocarbocyclic Nucleoside Analogs with an Optically Active Substituted Bicyclo[2.2.1]Heptane Fragment as a Glycoside Moiety (2019) (11)
Synthesis of novel azanorbornylpurine derivatives (2012) (11)
Biological or pharmacological activation of protein kinase C alpha constrains hepatitis E virus replication (2017) (11)
From norbornane-based nucleotide analogs locked in South conformation to novel inhibitors of feline herpes virus. (2014) (11)
Synthesis of novel carbocyclic nucleoside analogues derived from 7-oxabicyclo[2.2.1]heptane-2-methanol (2009) (11)
Mechanism of the Antiviral Activity of New Aurintricarboxylic Acid Analogues (1996) (11)
Synthesis, characterization and biological evaluation of thioureas, acylthioureas and 4-thiazolidinones as anticancer and antiviral agents (2017) (11)
Evaluation of the antiviral activity of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl]guanine (A-5021) against equine herpesvirus type 1 in cell monolayers and equine nasal mucosal explants. (2012) (11)
Identification of 2-(4-(Phenylsulfonyl)piperazine-1-yl)pyrimidine Analogues as Novel Inhibitors of Chikungunya Virus (2020) (11)
Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV. (2017) (11)
Phosphoramidate dinucleosides as hepatitis C virus polymerase inhibitors. (2008) (11)
Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases. (2017) (11)
Antiviral potential of “new” acyclic nucleoside phosphonates, the 6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines (2004) (11)
PRELIMINARY PHYTOCHEMICAL SCREENING AND STUDY OF ANTIVIRAL ACTIVITY AND CYTOTOXICITY OF WRIGHTIA TINCTORIA (2009) (11)
Impact of direct virus-induced neuronal dysfunction and immunological damage on the progression of flavivirus (Modoc) encephalitis in a murine model (2003) (11)
Novel Class of Chikungunya Virus Small Molecule Inhibitors That Targets the Viral Capping Machinery (2020) (10)
The anti-herpesvirus activity of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)-cycloprop-1'-yl]methyl]guanine is markedly potentiated by the immunosuppressive agent mycophenolate mofetil. (2001) (10)
Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives. (2003) (10)
A Refined Guinea Pig Model of Foot-and-Mouth Disease Virus Infection for Assessing the Efficacy of Antiviral Compounds. (2016) (10)
3'-Deoxy phosphoramidate dinucleosides as improved inhibitors of hepatitis C virus subgenomic replicon and NS5B polymerase activity. (2010) (10)
Use of digoxigenin-labelled probes for the quantitation of HBV-DNA in antiviral drug evaluation. (1999) (10)
Synthesis and Antiviral and Cytostatic Activities of Carbocyclic Nucleosides Incorporating a Modified Cyclobutane Ring (1999) (10)
Establishing a Unified COVID-19 “Immunome”: Integrating Coronavirus Pathogenesis and Host Immunopathology (2020) (10)
Structural and functional similarities in bunyaviruses: Perspectives for pan‐bunya antivirals (2019) (10)
Anti-norovirus activity of C7-modified 4-amino-pyrrolo[2,1-f][1,2,4]triazine C-nucleosides. (2020) (10)
GS-9190, a novel substituted imidazo-pyridine analogue, is a potent inhibitor of hepatitis C virus replication in vitro and remains active against known drug-resistant mutants (2007) (10)
Molnupiravir (EIDD-2801) inhibits SARS-CoV2 replication in Syrian hamsters model (2020) (10)
Antiviral activity of carbohydrate-binding agents by interrupting the interaction between DC-SIGN and dengue virus (2009) (10)
Synthesis and Antiviral Evaluation of 2′-C-Methyl Analogues of 5-Alkynyl- and 6-Alkylfurano- and Pyrrolo[2,3-d]Pyrimidine Ribonucleosides (2009) (9)
Comparative analysis of the anti-chikungunya virus activity of novel bryostatin analogs confirms the existence of a PKC-independent mechanism. (2016) (9)
The combined treatment of Molnupiravir and Favipiravir results in a marked potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model (2020) (9)
Identification of Broad‐Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6‐Diaminopurine Scaffolds (2018) (9)
Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen. (2021) (9)
Heterocyclic pharmacochemistry of new rhinovirus antiviral agents: A combined computational and experimental study. (2017) (9)
Species Specificity of Type III Interferon Activity and Development of a Sensitive Luciferase-Based Bioassay for Quantitation of Mouse Interferon-λ (2018) (9)
In vitro surrogate models to aid in the development of antivirals for the containment of foot-and-mouth disease outbreaks. (2014) (9)
A Dengue type 2 reporter virus assay amenable to high-throughput screening. (2020) (9)
Glutathione is a highly efficient thermostabilizer of poliovirus Sabin strains. (2017) (9)
Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication. (2019) (9)
Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication (2011) (9)
Effect of TNP-470 (AGM-1470) on the Growth of Rat Rhabdomyosarcoma Tumors of Different Sizes (2001) (9)
Human cytomegalovirus modulates the Ca2+ response to vasopressin and ATP in fibroblast cultures. (1995) (9)
A Viral Polymerase Inhibitor Reduces Zika Virus Replication in the Reproductive Organs of Male Mice (2019) (9)
Small-molecule inhibitors of TBK1 serve as an adjuvant for a plasmid-launched live-attenuated yellow fever vaccine (2020) (9)
Intra-host emergence of an enterovirus A71 variant with enhanced PSGL1 usage and neurovirulence (2019) (9)
Synthesis, antiviral and cytostatic activities of carbocyclic nucleosides incorporating a modified cyclopentane ring. Part 2: Adenosine and uridine analogues. (1998) (9)
Novel substituted 9-norbornylpurines and their activities against RNA viruses. (2012) (8)
The path towards effective antivirals against rabies (2017) (8)
Synthesis and antiviral activities of new acyclic and "double-headed" nucleoside analogues. (2007) (8)
Upregulation of sodium taurocholate cotransporter polypeptide during hepatogenic differentiation of umbilical cord matrix mesenchymal stem cells facilitates hepatitis B entry (2017) (8)
1,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors. (2021) (8)
Protective activity of the lipid A analogue GLA-60 against murine cytomegalovirus infection in immunodeficient mice. (1993) (8)
Exploration of the anti-enterovirus activity of a series of pleconaril/pirodavir-like compounds (2015) (8)
Improved crystallization of the coxsackievirus B3 RNA-dependent RNA polymerase. (2007) (8)
An ocular model of Adenovirus type 5 infection in the rabbit. (1995) (8)
Potent neutralizing anti-SARS-CoV-2 human antibodies cure infection with SARS-CoV-2 variants in hamster model (2021) (8)
Antiviral drug discovery against arthritogenic alphaviruses: tools and molecular targets. (2019) (8)
Diagnostic performance and application of two commercial cell viability assays in foot-and-mouth disease research. (2011) (8)
Host Defense Mechanisms Against Murine Cytomegalovirus Infection Induced by Poly l:C in Severe Combined Immune Deficient (SCID) Mice (1994) (8)
Repurposing Drugs for Mayaro Virus: Identification of EIDD-1931, Favipiravir and Suramin as Mayaro Virus Inhibitors (2021) (8)
Synthesis and antiviral activities of quinazolinamine-coumarin conjugates toward chikungunya and hepatitis C viruses. (2022) (8)
Zika and Other Emerging Viruses: Aiming at the Right Target (2016) (7)
Development of New Sulfur-Containing Conjugated Compounds as Anti-HCV Agents (2011) (7)
In vitro combinations containing Tegobuvir are highly efficient in curing cells from HCV replicon and in delaying/preventing the development of drug resistance. (2015) (7)
Hydantoin: The mechanism of its in vitro anti-enterovirus activity revisited. (2016) (7)
Complete Genome Sequence of a Rat Hepatitis E Virus Strain Isolated in the United States (2014) (7)
Updated vaccine protects from infection with SARS-CoV-2 variants, prevents transmission and is immunogenic against Omicron in hamsters (2022) (7)
Synthesis and antiviral activity of novel derivatives of 2'-beta-C-methylcytidine. (2008) (7)
Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort (2022) (7)
Antiviral effects of selected nucleoside analogues against human parechoviruses A1 and A3. (2019) (7)
Corrigendum to “Selective inhibition of hepatitis B virus replication by RNA interference” [Biochem. Biophys. Res. Commun. 309 (2003) 482–484] (2005) (7)
Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-Methyltransferase (2021) (7)
Synthesis of novel racemic carbocyclic nucleoside analogues derived from 4,8-dioxatricyclo[4.2.1.03,7]nonane-9-methanol and 4-oxatricyclo[4.3.1.03,7]decane-10-methanol, compounds with activity against Coxsackie viruses (2009) (7)
Preliminary report of anti-hepatitis C virus activity of chloroquine and hydroxychloroquine in huh-5-2 cell line (2006) (7)
Absence of infectious retinitis after injection of human cytomegalovirus into rabbit eyes. (1995) (7)
Current and Future Antiviral Strategies to Tackle Gastrointestinal Viral Infections (2021) (7)
MVA-CoV2-S Vaccine Candidate Neutralizes Distinct Variants of Concern and Protects Against SARS-CoV-2 Infection in Hamsters (2022) (7)
Fitness and Virulence of a Coxsackievirus Mutant That Can Circumnavigate the Need for Phosphatidylinositol 4-Kinase Class III Beta (2013) (7)
Quinolinecarboxamides Inhibit the Replication of the Bovine Viral Diarrhea Virus by Targeting a Hot Spot for the Inhibition of Pestivirus Replication in the RNA-Dependent RNA Polymerase (2020) (7)
Protective activity of lipid A analogue GLA‐60 against murine cytomegalovirus infection in mice (1993) (7)
A new antiviral scaffold for human norovirus identified with computer-aided approaches on the viral polymerase (2019) (7)
R75761, a lead compound for the development of antiviral drugs in late stage poliomyelitis eradication strategies and beyond. (2008) (7)
Mannitol treatment is not effective in therapy of rabies virus infection in mice. (2017) (7)
Structural Insights into the Mechanisms of Action of Functionally Distinct Classes of Chikungunya Virus Nonstructural Protein 1 Inhibitors (2021) (7)
LP54 : Sofosbuvir inhibits hepatitis E virus replication in vitro and results in an additive effect when combined with ribavirin (2015) (7)
Synthesis and antiviral activity of boranophosphonate isosteres of AZT and d4T monophosphates. (2010) (6)
Modifications in the branched arms of a class of dual inhibitors of HIV and EV71 replication expand their antiviral spectrum (2019) (6)
3-(imidazo[1,2-a:5,4-b']dipyridin-2-yl)aniline inhibits pestivirus replication by targeting a hot spot drug binding pocket in the RNA-dependent RNA polymerase. (2016) (6)
Development of a foot-and-mouth disease infection model in severe combined immunodeficient mice for the preliminary evaluation of antiviral drugs. (2010) (6)
Heterocyclic rimantadine analogues with antiviral activity. (2003) (6)
COVID-19 and the intensive care unit: vaccines to the rescue (2021) (6)
Development and optimization of a high‐throughput screening assay for in vitro anti‐SARS‐CoV‐2 activity: Evaluation of 5676 Phase 1 Passed Structures (2022) (6)
The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of inosine monophosphate dehydrogenase (2005) (6)
Discovery of pyrazinone based compounds that potently inhibit the drug-resistant enzyme variant R155K of the hepatitis C virus NS3 protease. (2016) (6)
Antiviral treatment of feline immunodeficiency virus-infected cats with (R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine (2015) (6)
SARS-CoV-2 Omicron potently neutralized by a novel antibody with unique Spike binding properties (2022) (6)
The pulmonary vasculature in lethal COVID-19 and idiopathic pulmonary fibrosis at single-cell resolution (2022) (6)
The SARS-CoV-2 Alpha variant exhibits comparable fitness to the D614G strain in a Syrian hamster model (2022) (5)
Multivalent Tryptophan‐ and Tyrosine‐Containing [60]Fullerene Hexa‐Adducts as Dual HIV and Enterovirus A71 Entry Inhibitors (2021) (5)
2019 meeting of the global virus network (2019) (5)
Antiviral Agents Towards Chikungunya Virus: Structures, Syntheses, and Isolation from Natural Sources (2017) (5)
Anti-HIV and anti-HCMV Activities of New Aurintricarboxylic Acid Analogues (1995) (5)
Synthesis of 6-Arylthio Analogs of 2′,3′-Dideoxy-3′-Fluoroguanosine and Their Effect against Hepatitis B Virus Replication (2006) (5)
Synthesis of novel racemic carbocyclic nucleosides derived from 5,6-disubstituted norbornene (2010) (5)
A dual-antigen self-amplifying RNA SARS-CoV-2 vaccine induces potent humoral and cellular immune responses and protects against SARS-CoV-2 variants through T cell-mediated immunity (2022) (5)
Synthesis of Novel Types of Anti-Coxsackie Virus Compounds (2007) (5)
Therapy for herpesvirus infections (1991) (5)
A thiazepino[4,5-a]benzimidazole derivative hampers the RNA replication of Eurasian serotypes of foot-and-mouth disease virus. (2014) (5)
Synthesis of novel thienonorbornylpurine derivatives (2012) (5)
Animal experiments show impact of vaccination on reduction of SARS-CoV-2 virus circulation: A model for vaccine development? (2021) (5)
Drug development of an affinity enhanced, broadly neutralizing heavy chain-only antibody that restricts SARS-CoV-2 in rodents (2021) (5)
A novel therapeutic HBV vaccine candidate induces strong polyfunctional cytotoxic T cell responses in mice (2021) (5)
Intra-host variation structure of classical swine fever virus NS5B in relation to antiviral therapy. (2013) (5)
Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold. (2018) (5)
Comparing immunogenicity and protective efficacy of the yellow fever 17D vaccine in mice (2021) (5)
VP1 crystal structure-guided exploration and optimization of 4,5-dimethoxybenzene-based inhibitors of rhinovirus 14 infection. (2016) (5)
Synthesis of Novel Purine‐Based Coxsackievirus Inhibitors Bearing Polycylic Substituents at the N‐9 Position (2014) (5)
Nelfinavir markedly improves lung pathology in SARS-CoV-2-infected Syrian hamsters despite lack of an antiviral effect (2021) (5)
ACE2 engagement exposes the fusion peptide to pan-coronavirus neutralizing antibodies (2022) (4)
PI4KIII inhibitor enviroxime impedes the replication of the hepatitis C virus by inhibiting PI3 kinases (2018) (4)
Live-attenuated YF17D-vectored COVID-19 vaccine protects from lethal yellow fever virus infection in mouse and hamster models (2022) (4)
Double Arylation of the Indole Side Chain of Tri- and Tetrapodal Tryptophan Derivatives Renders Highly Potent HIV-1 and EV-A71 Entry Inhibitors (2021) (4)
A reassessment of mycophenolic acid as a lead compound for the development of inhibitors of chikungunya virus replication (2017) (4)
Synthesis of Enantiomerically Pure 1′,2′-cis-dideoxy, -dideoxydidehydro, -ribo and -deoxy Carbocyclic Nucleoside Analogues (2018) (4)
Short and efficient access to imidazo[1,2-a]pyrrolo[3,2-c]pyridine derivatives (2010) (4)
Human Norovirus Efficiently Replicates in Differentiated 3D-Human Intestinal Enteroids (2022) (4)
Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19 (2022) (4)
A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity In Vitro and In Vivo (2021) (4)
Synthesis of 5-Aryltriazole Ribonucleosides via Suzuki Coupling and Promoted by Microwave Irradiation. (2007) (4)
A High-Throughput Yellow Fever Neutralization Assay (2022) (4)
Budding yeast as a screening tool for discovery of nucleoside analogs for use in HSV-1 TK suicide-gene therapy. (1999) (4)
Progress in human picornavirus research: New findings from the AIROPico consortium (2019) (4)
Multi-Target CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach. (2019) (4)
Perspectives for the Treatment of Infections withFlaviviridae (2000) (4)
Detection of substances recognized by antisera directed against vertebrate somatotropin, prolactin and placental lactogen, within the brain of the insect Locusta migratoria: A comparison of immunocytochemical localization patterns (1990) (4)
NMR-based conformational analysis of 2',6-disubstituted uridines and antiviral evaluation of new phosphoramidate prodrugs. (2015) (4)
Cytidine nucleoside analog is an effective antiviral drug against Trichomonasvirus. (2021) (4)
Ribavirin Derivatives with a Hexitol Moiety: Synthesis and Antiviral Evaluation (2003) (4)
Substituted 5‐Benzyl‐2‐phenyl‐5H‐imidazo[4,5‐c]pyridines: A New Class of Pestivirus Inhibitors. (2007) (4)
mTOR-inhibitors may aggravate chronic hepatitis E. (2014) (4)
Mouse and hamster models for the study of therapy against flavivirus infections. (2006) (4)
Comparative analysis of the molecular mechanism of resistance to vapendavir across a panel of picornavirus species (2020) (4)
Human Cytomegalovirus Stimulates Thymidylate Synthase in Human Embryonic Lung Cells: A Possible Target for Anti-HCMV Therapy? (1995) (4)
Antiviral and immunomodulatory activity of the metal chelator ethylenediaminedisuccinic acid against cytomegalovirus in vitro and in vivo. (2002) (4)
Strategies for the treatment of cytomegalovirus infections (1993) (4)
Antiviral and Cytotoxic Activity of Different Plant Parts of Banana (Musa spp.) (2020) (4)
The legacy of ZikaPLAN: a transnational research consortium addressing Zika (2021) (3)
Mechanical ventilation affects respiratory microbiome of COVID-19 patients and its interactions with the host (2020) (3)
Luminescence-based Antiviral Assay for Hepatitis E Virus (2014) (3)
Activity of the anti-HIV agent 9-(2-phosphonyl-methoxyethyl)-2,6-diaminopurine against cytomegalovirus in vitro and in vivo (1993) (3)
HIV protease inhibitors Nelfinavir and Lopinavir/Ritonavir markedly improve lung pathology in SARS-CoV-2-infected Syrian hamsters despite lack of an antiviral effect (2022) (3)
Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity (2022) (3)
Mycophenolic acid, an immunosuppressive agent, inhibits replication in cultures of primary an immortalized human hepatocytes (1997) (3)
Enhanced efficacy of endonuclease inhibitor baloxavir acid against orthobunyaviruses when used in combination with ribavirin. (2020) (3)
In vivo antiviral activity of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine and its cyclic form (2007) (3)
Substituted Imidazopyridines as Potent Inhibitors of Hepatitis C Virus Replication that Target the Viral Polymerase (2007) (3)
Gammaherpesviruses encode functional dihydrofolate reductase activity. (2002) (3)
Molnupiravir inhibits the replication of the emerging SARS-CoV-2 variants of concern ( VoCs ) in a hamster infection model (2021) (3)
Itraconazole for COVID-19: Preclinical Studies and a Proof-of-Concept Pilot Clinical Study (2020) (3)
SARS-CoV-2 infection leads to cardiac pericyte loss, fibrosis, cardiomyocyte hypertrophy, and diastolic dysfunction (2020) (3)
169Targeting the Flavivirus Helicase (2011) (3)
Assessing In Vitro Resistance Development in Enterovirus A71 in the Context of Combination Antiviral Treatment. (2021) (3)
New Analogs of Acyclovir Substituted at the Side Chain (2007) (3)
Anti-SARS-CoV-2 human antibodies retaining neutralizing activity against SARS-CoV-2 B.1.1.529 (omicron) (2021) (3)
Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication (2022) (3)
SARS-CoV-2 Virion Infectivity and Cytokine Production in Primary Human Airway Epithelial Cells (2022) (3)
Conformationally locked nucleoside analogues based on the bridgehead substituted 7-oxonorbornane and their antiviral properties (2011) (3)
Exploring the importance of zinc binding and steric/hydrophobic factors in novel HCV replication inhibitors. (2016) (3)
Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease (2022) (3)
Selecting and characterizing drug-resistant hepatitis C virus replicon. (2013) (3)
STAT1-dependent tolerance of intestinal viral infection (2020) (3)
The development of RNA-KISS, a mammalian three-hybrid method to detect RNA - protein interactions in living mammalian cells. (2020) (2)
High transmissibility and fetal pathogenicity of recent Zika virus strains from the African lineage (2020) (2)
Need for a Standardized Translational Drug Development Platform: Lessons Learned from the Repurposing of Drugs for COVID-19 (2022) (2)
Methods in Anti-HCMV Research. (2000) (2)
Anatomical barriers against SARS-CoV-2 neuroinvasion at vulnerable interfaces visualized in deceased COVID-19 patients (2022) (2)
Biodistribution and environmental safety of a live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate (2022) (2)
Understanding the molecular mechanism of host-based statin resistance in hepatitis C virus replicon containing cells. (2015) (2)
Assessment of the anti-norovirus activity in cell culture using the mouse norovirus: Identification of active compounds (2021) (2)
Cross-Metathesis Mediated Synthesis of New Acyclic Nucleoside Phosphonates (2007) (2)
Assessment of the activity of directly acting antivirals and other products against different genotypes of hepatitis C virus prevalent in resource-poor countries. (2016) (2)
Novel symmetrical phenylenediamines as potential anti-hepatitis C virus agents (2015) (2)
Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts (2021) (2)
New inhibitors of cytomegalovirus replication: in vitro evaluation, mechanism of action, and in vivo activity. (1994) (2)
Efficacy of HPMPC in the treatment of CMV infections in various animal models (1993) (2)
Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-a]pyrimidines as potential anti-chikungunya agents (2020) (2)
Effect of polyanionic compounds on intracutaneous and intravaginal herpes virus infection in mice: Impact on the search for vaginal microbicides (1995) (2)
Molecular Dynamic Study and Synthesis of 1H-benzo[d]imidazole-5-carboxamide Derivatives as Inhibitors for Yellow Fever and Zika Virus Replication (2020) (2)
Identification of host factors binding to dengue and Zika virus subgenomic RNA by efficient yeast three-hybrid screens of the human ORFeome (2021) (2)
Assessment of the anti-norovirus activity in cell culture using the mouse norovirus: Early mechanistic studies (2021) (2)
New Conjugated Compounds Coming On Stream against Hepatitis C Virus (2016) (2)
In silico development of a novel putative inhibitor of the 3C protease of Coxsackievirus B3 with a benzene sulfonamide skeleton (2017) (2)
Strategies for the treatment and prevention of cytomegalovirus infections. (1993) (2)
841 BC556, A POTENT, PAN-GENOTYPIC, HIGH BARRIER TO RESISTANCE, SECOND GENERATION CYCLOPHILIN INHIBITOR FOR TREATMENT OF CHRONIC HCV INFECTION (2012) (2)
Synthesis, Antiretroviral and Antioxidant Evaluation of a Series of New Benzo[b]furan Derivatives (2001) (2)
Differential antiviral activities of RSV inhibitors in human airway epithelium (2018) (1)
A Novel 9-Arylpurine Acts as a Selective Inhibitor of In Vitro Enterovirus Replication Possibly by Targeting Virus Encapsidation (2010) (1)
Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates (2023) (1)
SELECTED READING (2018) (1)
Synthesis of new 3-acetyl-1,3,4-oxadiazolines combined with pyrimidines as antileishmanial and antiviral agents (2022) (1)
Pan-ErbB inhibition protects from SARS-CoV-2 replication, inflammation, and injury (2021) (1)
γ-Carboline Derivatives as Potent and Selective Inhibitors of Bovine Viral Diarrhea Virus (BVDV) Replication (2010) (1)
Synthesis and Antiviral Evaluation of 2′‐C‐Methyl Analogues of 5‐Alkynyl‐ and 6‐Alkylfurano‐ and Pyrrolo[2,3‐d]pyrimidine Ribonucleosides. (2010) (1)
Synthesis of Novel Racemic Carbocyclic Nucleosides Derived from 5,6‐Disubstituted Norbornene. (2010) (1)
New treatment strategies for dengue and other flaviviral diseases (2006) (1)
3 C Protease of Enterovirus 68 : Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against (2013) (1)
Kinetic, mechanistic and chemodynamic characterisation of non-nucleoside hepatitis C virus NS5B polymerase inhibitors using SPR biosensor technology (2009) (1)
Spiro[pyrrolidine‐2,2′‐adamantanes]: Synthesis, Antiinfluenza Virus Activity and Conformational Properties. (2003) (1)
Safety Assessment in Pigs of an Experimental Molecule with In-Vitro Antiviral Activity Against African Swine Fever (2013) (1)
Small molecule inhibitors of TBK1 as adjuvant for the Plasmid-Launched Live Attenuated Vaccine against the yellow fever virus (2019) (1)
Rational modifications, synthesis and biological evaluation of new potential antivirals for RSV designed to target the M2-1 protein. (2020) (1)
Synthesis and Antiviral Evaluation of Ribavirin Congeners Containing a Hexitol Moiety (2003) (1)
Updated vaccine protects against SARS-CoV-2 variants including Omicron (B.1.1.529) and prevents transmission in hamsters (2022) (1)
Ivermectin Does Not Protect against SARS-CoV-2 Infection in the Syrian Hamster Model (2022) (1)
Synthesis and antiviral activity of various N4-acyl derivatives of cidofovir and its 5-azacytosine counterpart, 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine (2008) (1)
Viral Genome Dynamics During Antiviral Resistance Selection: A First Glimpse into Viral Evolution (2011) (1)
Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [HPMPC] against intraperitoneal and intracerebral murine cytomegalovirus infections (1991) (1)
Structure–Activity Relationship Studies on Novel Antiviral Agents for Norovirus Infections (2021) (1)
Adefovir serum levels do not differ between responders and nonresponders (2011) (1)
Assessing the in vitro resistance development in Enterovirus 71 in the context of combination antiviral treatment (2020) (1)
Flaviviridae with Perspectives for the Treatment of Infections (1999) (1)
In vitro assay to assess efficacy of potential antiviral compounds against enterovirus D68 (2017) (1)
Antiviral activity of carbohydrate binding agents (CBAS) and the role of DC-SIGN in Dengue virus and HIV infection (2009) (1)
Synthesis, X-ray crystallographic analysis, DFT studies and biological evaluation of triazolopyrimidines and 2-anilinopyrimidines (2021) (1)
Synthesis and evaluation of 3-alkynyl-5-aryl-7-aza-indoles as broad-spectrum antiviral agents (2022) (1)
Specific phosphorylation of 2-amino-7-[(1,3-dihydroxy-2-propoxymethyl)purine (S2242) in human cytomegalovirus-infected human embryonic lung fibroblasts (1995) (1)
Isolation of phenanthrenes and identification of phorbol ester derivatives as potential anti-CHIKV agents using FBMN and NAP from Sagotia racemosa. (2019) (1)
Bacterial Artificial Chromosomes (2014) (1)
Erratum to “Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virus” [J Hepatol 2012;57:246–251] (2013) (1)
Screening and in vitro antiviral assessment of small molecules against fluorescent protein-expressing Bunyamwera virus in a cell-based assay using high-content imaging (2021) (1)
In vitro inhibition of severe acute respiratory syndrome coronavirus by primaquine. (2009) (1)
Corrigendum to “itraconazole for COVID-19: Preclinical studies and a proof-of-concept randomized clinical trial Laurens” (2021) (1)
The Twenty-Second International Conference on Antiviral Research (2009) (1)
Infectious Virus Yield Assay for Hepatitis E Virus (2014) (1)
A derivate of the antibiotic doxorubicin inhibits dengue and yellow fever virus replication in vitro (2008) (1)
239 EMBRYOTOXICITY ASSAY FOR ANTIVIRAL COMPOUND BPIP (5-[(4-BROMOPHENYL)METHYL]-2-PHENYL-5H-IMIDAZO[4,5-c]PYRIDINE) IN BOVINE IN VITRO-PRODUCED EMBRYOS (2007) (1)
ID: 146: Interferon lambda prevents mouse-to-mouse norovirus transmission (2015) (1)
A novel class of small molecule inhibitors targeting the chikungunya virus capping machinery with a high barrier to resistance (2019) (1)
Antiviral effect of the nucleoside analogue cidofovir in the context of sexual transmission of a gammaherpesvirus in mice (2018) (1)
In vivo monitoring of acute flavivirus (Modoc) encephalitis with regional and whole-brain quantitative diffusion magnetic resonance imaging (2004) (1)
Mycophenolic Acid Has Intrinsic Antiviral Properties and Potentiates the Antiviral Effect of Ribavirin on Parainfluenza Virus. (2020) (1)
European Training Network on (+)RNA Virus Replication and Antiviral Drug Development (2011) (1)
The Imidazopyrrolopyridine Analogue AG110 is a Novel, Highly Selective Inhibitor of Pestivirus Replication and Targets the viral RNA-dependent RNA Polymerase (2007) (1)
Differential antiviral activity of several IMP dehydrogenase inhibitors (1997) (1)
Structure of Coxsackievirus A16 in complex with GPP3 (2015) (1)
Novel 9-Arylpurines, as Selective Inhibitors of In Vitro Enterovirus Replication (2009) (1)
Chemical Evolution of Antivirals Against Enterovirus D68 through Protein‐Templated Knoevenagel Reactions (2021) (1)
In Vitro Combination Therapy with Tegobuvir (GS-9190) is Highly Efficient in Curing Cells from HCV Replicon and in Delaying/Preventing the Development of Antiviral Resistance (2011) (1)
New Models to Study Hepatitis E Virus Replication and Particular Characteristics of Infection: The Needle Hides in the Hay Stack. (2018) (1)
In vitro Anti-hepatitis C Virus (HCV) Activities and Resistance Profile of Debio 025, A Non-immunosuppressive Cyclophilin Binding Molecule (2009) (1)
Nirmatrelvir-resistant SARS-CoV-2 is efficiently transmitted in Syrian hamsters (2022) (1)
Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts (2022) (1)
The picornavirus inhibitor enviroxime inhibits HCV RNA replication in vitro by inhibiting PI4KIII (2012) (1)
Computer-aided Design and Evaluation of Novel Anti-CHIKV Compounds (2011) (1)
Novel 3‐(2‐Adamantyl)pyrrolidines with Potent Activity Against Influenza A Virus — Identification of Aminoadamantane Derivatives Bearing Two Pharmacophoric Amine Groups. (2001) (1)
Coumarins Hybridized with Heterocycles or Ribonucleosides for Eradication of Hepatitis C Virus (2011) (1)
Animal models for COVID-19 (2020) (0)
Hantavirus infection in Belgium (1994) (0)
Identification of a druggable VP1-VP3 interprotomer pocket in the capsid of enteroviruses (2019) (0)
Mevastatin Markedly Potentiates the Anti-HCV Activity of Selective Inhibitors of HCV Replication and Delays or Prevents the Emergence of Antiviral Resistance (2008) (0)
Organotropic dendrons with high potency as HIV-1, HIV-2 and EV-A71 cell entry inhibitors. (2022) (0)
Restriction of Viral Replication, Rather than T Cell Immunopathology, Drives Lethality in Murine Norovirus CR6-Infected STAT1-Deficient Mice (2022) (0)
Introduction to the Special Issue dedicated to Prof. Erik De Clercq for reaching the Professor Emeritus status at the Katholieke Universiteit Leuven (2006) (0)
Resistance of HCV replication to statins is conferred by cellular changes (2013) (0)
Drug Design of New NS3/4A HCV Serine Protease Inhibitors. Structure-Based and Ligand-Based Approaches. (2009) (0)
Structural Investigations on Novel Non-Nucleoside Inhibitors of Human Norovirus Polymerase (2022) (0)
Differential anti-hepatitis B virus activity in vitro of three potent of inosine monophosphate dehydrogenase inhibitors: mycophenolic acid (MPA), 5-ethynyl-1-β-d-ribofuranosyli-midazole-4-carboxamide (EICAR) and ribavirin (1998) (0)
Development of a Plasmid-Launched Live-Attenuated Viral vaccine (PLLAV) platform to generate novel multi-valent vaccines against viral pathogens (2019) (0)
Pharmacology and Mechanisms of Action of Antiviral Drugs: Polymerase Inhibitors (2011) (0)
Hepatitis C virus (HCV) proteins stimulate the expression of pro-angiogenic factors in hepatocellular carcinoma cells (2014) (0)
Identification of a novel resistance mutation for hepatitis C virus benzimidazole inhibitor JT-16 (2012) (0)
Pan-viral protection against arboviruses by targeting inoculation site-based skin macrophages (2019) (0)
Rational design of novel nucleoside analogues reveals potent antiviral agents for EV71. (2022) (0)
Consistent antiviral activity of carbohydrate-binding agents against the 4 different serotypes of dengue virus (2009) (0)
Restriction of viral replication, rather than T cell immunopathology, drives lethality in MNV CR6-infected STAT1-deficient mice (2022) (0)
Efficient immunization and full protection from lethal challenge by PLLAV-YF17D, a novel thermostable and readily scalable plasmid-launched life-attenuated yellow fever vaccine candidate produced in E. coli (2017) (0)
Developing pan-bunyavirus antivirals: Shared proteins, shared targets (2019) (0)
Selective inhibitors of the replication of poxviruses (2006) (0)
Mechanism of anti-human immunodeficiency virus (HIV) action of selected ATA-polymer analogues (1995) (0)
Intracellular metabolism of the novel anti-herpesvirus agent 2-amino-7-[1,3-dihydroxy-2-propoxy)methyl]purine compound S2242 in non-infected and herpesvirus-infected cells (1995) (0)
Mapping in vitro the lipophilic pocket of influenza A amantadine drug receptor - synthesis, anti-influenza virus activity and dynamic NMR properties supported with force field calculations of some spiranic aminodamantane heterocycles (2006) (0)
Reply: (2010) (0)
ISAR News (2018) (0)
SPECIAL COLLECTION : TRANSLATIONAL IMPACT OF RAT A rat model for hepatitis E virus (2016) (0)
Development of thermostable and easy to produce dual-target Ebola/yellow fever and Lassa/yellow fever vaccine candidates (2019) (0)
A second-generation of tryptophan-containing small molecules extremely potent against HIV and EV-A71 clinical isolates (2019) (0)
Selected talk 2 MCMV exploits the spleen as a transfer hub for systemic dissemination upon oronasal inoculation (2015) (0)
Rational design of antiviral drug combinations based on equipotency using HCV subgenomic replicon as an in vitro model. (2018) (0)
Studying the Dengue-Zika virus interaction with stress granules and the toolbox established to study this virus interaction (2019) (0)
Adefovir treatment failure is not associated with low serum drug levels (2010) (0)
in 1 vitro Zika virus replication and delays disease progression in a robust mouse infection model 2 3 Running Title : Inhibition of Zika virus replication (2016) (0)
AbstractAntiviral efficacy in mice of oral bis(POM)-PMEA, the Bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine (1995) (0)
The microRNA 221/222 cluster controls CVB3-induced myocarditis: could tiny microRNAs explain adverse inflammation in the heart? (2013) (0)
Activity of 7,8-dihydro-isoquinoline-6-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-amide hydrochloride salt against human cytomegalovirus (HCMV) (2002) (0)
789 PRECLINICAL CHARACTERIZATION OF NOVEL CYCLOPHILIN INHIBITORS BASED ON THE POLYKETIDE, SANGLIFEHRIN (2011) (0)
Diagnostic performance of two commercially available cell viability assays in foot-and-mouth disease research (2010) (0)
Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort (2022) (0)
Role of the hepatitis C virus/Amphiregulin axis in hepatocellular carcinoma-associated angiogenesis (2015) (0)
O118 A MUTATION IN THE HEPATITIS E VIRUS POLYMERASE ASSOCIATED WITH RIBAVIRIN TREATMENT FAILURE HAS A REPLICATION ADVANTAGE IN VITRO (2014) (0)
A pan-serotype antiviral to prevent and treat dengue: A journey from discovery to clinical development driven by public-private partnerships (2022) (0)
Faculty Opinions recommendation of Azithromycin induces anti-viral effects in cultured bronchial epithelial cells from COPD patients. (2017) (0)
Efficient Synthesis and anti‐Enteroviral Activity of 9‐Arylpurines. (2012) (0)
Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors (2022) (0)
P.091 Selection and phenotypic characterization of multiple drug resistant variants in patients with chronic hepatitis B (2006) (0)
A yellow fever–Zika chimeric virus vaccine candidate protects against Zika infection and congenital malformations in mice (2018) (0)
EVALUATION OF HEXADECYLOXYPROPYL-9- R -[2-(PHOSPHONOMETHOXY)PROPYL]-ADENINE, CMX157, AS A POTENTIAL TREATMENT OF HIV-1 AND HEPATITIS B VIRUS INFECTIONS (2007) (0)
Effect of hepatitis E virus infection on the human hepatic innate immune response in human liver chimeric mice (2016) (0)
Will virology ever have a 'penicillin moment'? (2014) (0)
Twenty-Fourth International Conference on Antiviral Research - Front Pages (2011) (0)
Broad-spectrum antiviral activity of polyoxometalates against human immunodeficiency virus and other enveloped viruses (1992) (0)
Conformationally Locked Nucleoside Analogues Based on the Bridgehead Substituted 7-Oxonorbornane and Their Antiviral Properties. (2012) (0)
HIV / HCV : nel fi navir as a potential starting point for broad-spectrum protease inhibitors against dengue and chikungunya virus † (2015) (0)
Discovery of a Novel Class of Norovirus Inhibitors with High Barrier of Resistance (2021) (0)
Anti-SARS-CoV-2 Activity and Cytotoxicity of Amaryllidaceae Alkaloids from Hymenocallis littoralis (2023) (0)
Thiazolobenzimidazoles as potent inhibitors of the in vitro replication of Coxsackie B virus (2006) (0)
Differential anti-HBV activity in vitro of three potent inhibitors of inosine monophosphate dehydrogenase: Mycophenolic acid 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR) and ribavirin (1998) (0)
The influence of cyclosporin and corticosteroids on HBV replication in primary cultures of human hepatocytes (1998) (0)
The cyclophilin inhibitor Debio 025 is highly efficient in clearing HCV replicon containing cells, alone or when combined with STAT-C inhibitors and has a unique resistance profile (2009) (0)
Faculty Opinions recommendation of Corticosteroids for the common cold. (2017) (0)
Title : 1 The viral polymerase inhibitor 2 ’-C-methylcytidine inhibits Norwalk 2 virus replication and protects against norovirus-induced diarrhea and 3 mortality in a mouse model 4 (2013) (0)
In Searching for New Antiinfluenza A Drugs: Heterocyclic and Carbocyclic Aminoadamantanes Bearing a 2‐Adamantyl Group with Potent Activity Against Influenza A Virus (2005) (0)
Faculty Opinions recommendation of Azithromycin maintenance treatment in patients with frequent exacerbations of chronic obstructive pulmonary disease (COLUMBUS): a randomised, double-blind, placebo-controlled trial. (2017) (0)
The role of DC-SIGN in HIV and dengue virus transmission and infection (2008) (0)
Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitro (2023) (0)
Computer-Aided Design and Synthesis of (Functionalized quinazoline)–(α-substituted coumarin)–arylsulfonate Conjugates against Chikungunya Virus (2022) (0)
Synthesis and Antiviral Activity Evaluation of Some New Aminoadamantane Derivatives. Part 2. (1996) (0)
IS INDEPENDENT OF ERROR-PRONE REPLICATION (2006) (0)
Crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase (3Dpol) in complex with a pyrophosphate (2008) (0)
Conservation of the pentanucleotide sequence at the top of the 3’ stem-loop of YFV is not required for replication in animal cell culture (2006) (0)
Identification of Z-Tyr-Ala-CHN2, a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2 (2023) (0)
Chimeric Live-Attenuated Zika/Japanese Encephalitis Virus (ZIK-JEprM/E) Vaccine Protects Against Both JEV and ZIKV (2019) (0)
Comparative Activity of Anti-Enteroviral Agents Against Poliovirus Replication In Vitro (2007) (0)
Conservation of the pentanucleotide motif in the yellow fever virus 3’ stem-loop structure is not required for replication (2007) (0)
PicornavirusesAntiviral Effects against Acceptor Inhibitors and Their Structure-Based Design of Michael 3C Protease of Enterovirus 68: (2013) (0)
Potential Use of Antiviral Agents in Polio Eradication (2008) (0)
1194 SYNERGISTIC COMBINATIONS OF ENTRY INHIBITORS WITH DACLATASVIR OR SOFOSBUVIR FOR PREVENTION AND TREATMENT OF CHRONIC HEPATITIS C (2013) (0)
Therapeutic potential of acyclic nucleoside phosphonates in the treatment of herpes- and retrovirus infections (i.e. HPMPC against MCMV infection in SCID mice) (1992) (0)
Insertion of an Amphipathic Linker in a Tetrapodal Tryptophan Derivative Leads to a Novel and Highly Potent Entry Inhibitor of Enterovirus A71 Clinical Isolates (2023) (0)
Small molecule inhibitor of TBK1 as adjuvant for the Plasmid-Launched Live-Attenuated Vaccine (PLLAV) against the yellow fever virus (2019) (0)
Crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase (3Dpol) in complex with protein primer VPg and a pyrophosphate (2008) (0)
Triazole derivatives as viral replication inhibitors (2008) (0)
The influences of immunosuppressive agents on HBV replication in vitro (1998) (0)
Phosphoramidate Protides Greatly Enhance the Anti-HCV Activity of 2′-Methylguanosine (2009) (0)
ANTIVIRAL AGENTS WITH BROAD-SPECTRUM: DESIGN, SYNTHESIS, AND ACTIVITIES (2022) (0)
Cu‐Mediated Selective N‐Arylation of Aminotriazole Acyclonucleosides. (2010) (0)
Full protection against all four SARS-CoV-2 variants of concern (VOC) in hamsters requires revision of spike antigen used for vaccination (2021) (0)
Pan-antivirals to combat re-emerging alphaviruses (2019) (0)
New Analogues of Acyclovir Substituted at the Side Chain (2008) (0)
Non-Nucleoside Inhibitors of HCMV Replication (2003) (0)
The substituted imidazopyridine GS-327073 is a potent inhibitor of HCV replication (2007) (0)
An Antiviral Assay to Identify Inhibitors of the Human Metapneumovirus that is Amenable for High-throughput Screening Purposes (2011) (0)
CHAPTER 8 INHIBITION OF BOVINE HERPESVIRUS 4 REPLICATION IN VITRO BY SELECTED ANTIVIRAL AGENTS (2002) (0)
Development of a dual-target rabies/yellow fever vaccine candidate (2019) (0)
Mycophenolate Mofetil markedly enhances the antiviral activity of acyclovir, ganciclovir and penciclovir against herpes simplex virus (wild type and TK− strains) and human cytomegalovirus (1997) (0)
HEV4 O‐22: Human liver chimeric mice as a novel model for the study of hepatitis E virus infections (2015) (0)
Upregulation of sodium taurocholate cotransporter polypeptide during hepatogenic differentiation of umbilical cord matrix mesenchymal stem cells facilitates hepatitis B entry (2017) (0)
Classical Swine Fever Outbreak Containment – Antivirals as an Epidemiologically and Economically Viable Alternative to Emergency Vaccination and Culling (2011) (0)
Development of near full-genome HCV1b resistance test (2007) (0)
Cover Feature: Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds (ChemMedChem 14/2018) (2018) (0)
Antiviral Strategies Against (Non‐polio) Picornaviruses (2021) (0)
Particular characteristics of the effect of statins on the life cycle of HCVcc (2010) (0)
Alpha variant versus D614G strain in the Syrian hamster model/ en (2021) (0)
As antivirals appropriate azacytosinderivate (2006) (0)
Chikungunya virus resistant to the antiviral favipiravir is severely attenuated in mosquitoes (2019) (0)
An Analogue of the Antibiotic Teicoplanin Inhibits Dengue Virus Entry In Vitro (2011) (0)
A Novel Method—Amenable for High-throughput Screening Purposes—to Quantify Antiviral Activity Against Viruses that Induce Limited CPE (2011) (0)
In Vitro Selection and Characterization of Hepatitis C Virus Replicons Double or Triple Resistant to Various Non-nucleoside HCV Polymerase Inhibitors (2010) (0)
shedding of murine norovirus in stool to undetectable levels (2015) (0)
Faculty Opinions recommendation of The main rhinovirus respiratory tract adhesion site (ICAM-1) is upregulated in smokers and patients with chronic airflow limitation (CAL). (2017) (0)
∆F13L-GFP-Vac (p37-deleted vaccinia virus) is attenuated in mice and protects against infection with wild-type virus (2006) (0)
Faculty Opinions recommendation of Lymphocyte subsets in experimental rhinovirus infection in chronic obstructive pulmonary disease. (2017) (0)
Particular characteristics of the in vitro anti-hepatitis C virus activity of Debio-025, a non-immunosuppressive cyclophilin binding molecule (2008) (0)
Thiazolobenzimidazoles, a Novel Class of Enterovirus Inhibitors, Target the 2C Protein (2007) (0)
705 Stimulation of Angiogenesis by Hepatitis C Virus (HCV) Non-structural Proteins (2012) (0)
Faculty Opinions recommendation of A highly structured, nuclease-resistant, noncoding RNA produced by flaviviruses is required for pathogenicity. (2009) (0)
MicroRNA-221/-222 amends protective mechanisms in CVB3-induced murine myocarditis (2014) (0)
In vitro selection and characterization of HCV replicons dually resistant to various non-nucleoside polymerase inhibitors (2009) (0)
F-102 Antivirals, a lot has been achieved, yet a long way to go (2019) (0)
inhibits SARS-CoV-2 replication and enhances the efficacy of favipiravir in 1 a Syrian hamster infection model 2 (2021) (0)
Unique in vitro resistance profile of the cyclophilin inhibitor Debio 025 (2009) (0)
In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses (2015) (0)
Synthesis and antiviral activity of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine and its ester prodrugs (2007) (0)
Study of the mechanism of HCV resistance to PI4KIII inhibitors enviroxime and compound A (2013) (0)
A yellow fever vaccine virus-based therapeutic hepatitis B vaccine candidate inducing vigorous cytotoxic T cell responses (2019) (0)
Synthesis, characterization, molecular docking, and anticancer activities of new 1,3,4-oxadiazole-5-fluorocytosine hybrid derivatives (2022) (0)
Novel strategies for the treatment of infections with the hepatitis C virus (2010) (0)
Synthesis and antiviral evaluation of benzyl-substituted thiopurine and tiazofurin derivatives (1997) (0)
Assessing the Efﬁcacy of Cidofovir against Herpesvirus-Induced Genital Lesions in Goats Using Different Therapeutic Regimens (cid:1) (2008) (0)
Development of a robust and convenient dual-reporter high-throughput screening assay for SARS-CoV-2 antiviral drug discovery (2022) (0)
Synthesis and biological evaluation of hydrophobic nucleoside a potential antiviral therapeutics (2013) (0)
Host Defense Mechanisms Against Murine Cyt omeg alovi r us I nf ect i on I nd u ced by Poly I:C in Severe Combined Immune Deficient (SCID) Mice (43806) (1994) (0)
Eradication of Persistent Bovine Viral Diarrhea Virus Infection in Cell Culture by Antiviral Treatment: How to Get Ahead of the Viral Evasion Strategy (2010) (0)
Enhanced antiviral activity of hexadecyloxypropyl-PME-N-6-cyclopropyl-diaminopurine against herpesviruses, hepatitis B virus and vaccinia virus, in vitro (2007) (0)
Inhibitory effect of 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) on hepatitis B virus replication in vitro (1998) (0)
Late Breaker Oral Presentation Sessions (2017) (0)
Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that bind a conserved membrane proximal epitope of the spike (2023) (0)
Reverse engineering synthetic antiviral amyloids (2020) (0)
Inhibition of human norovirus replication by a novel class of indolylarylsulfones in vitro and in zebrafish larvae (2019) (0)
Synthesis of Novel Carbocyclic Nucleoside Analogues Derived from 7‐Oxabicyclo[2.2.1]heptane‐2‐methanol. (2009) (0)
P0692 : PKC/AP-1 signaling drives transcription of interferon-stimulated genes and exerts potent antiviral activity against hepatitis C and E viruses (2015) (0)
3 ',5 ' di-O-Trityluridine Inhibits Flavivirus (Dengue and Yellow Fever Virus) Replication and Targets the Viral RNA Dependent RNA Polymerase (2011) (0)
Science communications on a pandemic during the pandemic (2021) (0)
The genetic evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (2021) (0)
Combination of the parent analogue of remdesivir (GS-441524) and molnupiravir results in a markedly potent antiviral effect in SARS-CoV-2 infected Syrian hamsters (2022) (0)
Inhibition of coxsackie B3 virus infection in vitro and in a murine model of virus-induced myocarditis by 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (2003) (0)
DC-SIGN: An important attachment receptor for dengue virus and for development of antiviral therapy with carbohydrate-binding agents (2010) (0)
P0488 : Dissecting the complexity of interferon response that cross talks with 4E-BP1 in hepatitis E virus infection (2015) (0)
Systems vaccinology of YF17D immunization in mice (2019) (0)
Cidofovir Tumor Formation by the Acyclic Nucleoside Phosphonate Inhibition of Fibroblast Growth Factor-2-induced Vascular Updated (2001) (0)
Publisher Correction: A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction (2021) (0)
Hepatitis E virus replication and interferonresponse in human placental-derived cells (2018) (0)
Anti-Coxsackievirus B activity of 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile analogues (2005) (0)
Metabolically Improved Stem Cell Derived Hepatocyte-Like Cells Support HBV Life Cycle and Are a Promising Tool for HBV Studies and Antiviral Drug Screenings (2022) (0)
The inability of flaviviruses with a not known vector to replicate in mosquito cells is not determined by the viral envelope proteins (2006) (0)
Phosphoramidate Dinucleosides as Inhibitors of Hepatitis C Virus Subgenomic Replicon and NS5B Polymerase Activity (2011) (0)
Rapid and convenient assays to assess potential inhibitory activity on in vitro 1 hepatitis A replication 2 (2013) (0)
Genetic consequences of effective and suboptimal dosing with mutagenic drugs in a hamster model of SARS-CoV-2 infection (2023) (0)
Identification and Analysis of Antiviral Compounds Against Poliovirus. (2016) (0)
Potent inhibition of human cytomegalovirus (HCMV) replication by alkenyl guanine analogs with a thiazole[4,5-d]pyrimidine ring (1999) (0)
An animal model for the study of therapy against dengue virus infections (2006) (0)
New nucleotide analogues as antiviral molecules precursors to (2006) (0)
Synthesis of 3’- and 5’-modified nucleosides analogs for inhibition of flavivirus replication (2012) (0)
The dissemination of Rift Valley fever virus to the eye and sensory neurons of zebrafish larvae is stat1 dependent (2022) (0)
Requirements at the purine moiety for the inhibitory activity of 9-arylpurines against coxsackie virus B3 (CVB3) replication (2009) (0)
Effect of Hepatitis B virus replication on oxidative stress, gene expression and induction of genetic changes in an inducible cell culture model of HepAD38 cells (2005) (0)
One nucleoside viral polymerase inhibitor that blocks the replication of norovirus, rotavirus and sapoviruses (2019) (0)
Validation of a Reporter Cell Line for Flavivirus Inhibition Assays (2023) (0)
Novel nucleotide analogues as antiviral precursor molecules (2006) (0)
Structure of the EVA71 strain 11316 capsid (2019) (0)
Comparative Study of the Genetic Barrier and Pathways Towards Resistance of Selective Inhibitors of HCV Replication (2009) (0)
BetaPhosphatidylinositol 4-Kinase Class III Mutant That Can Circumnavigate the Need Fitness and Virulence of a Coxsackievirus (2014) (0)
Faculty Opinions recommendation of A genetically humanized mouse model for hepatitis C virus infection. (2011) (0)
A single mutation in the chikungunya virus RNA polymerase causes resistance to Favipiravir (T-705) (2014) (0)
A high-throughput neutralization assay for yellow fever serodiagnostics (2021) (0)
Towards the development of potent therapy against the Hepatitis C virus (2011) (0)
124 HEPATOCYTES DERIVED FROM HUMAN PLURIPOTENT STEM CELLS PERMIT COMPLETE REPLICATION OF THE HEPATITIS C VIRUS (2012) (0)
Faculty Opinions recommendation of Enhanced infection of liver sinusoidal endothelial cells in a mouse model of antibody-induced severe dengue disease. (2010) (0)
Intranasal administration of convalescent plasma protects against SARS-CoV-2 infection in hamsters (2023) (0)
EV-A71 strain 11316 complexed with tryptophan dendrimer MADAL_0385 (2019) (0)
The Role of Histo-Blood Group Antigens and Microbiota in Human Norovirus Replication in Zebrafish Larvae (2022) (0)
Antiviral Targets and Strategies to Treat and Prevent Human Norovirus Infections (2021) (0)
The Urtica Dioica Agglutinin Prevents Rabies Virus Infection in a Muscle Explant Model (2021) (0)
Synthesis of Novel Racemic Carbocyclic Nucleoside Analogues Derived from 4,8‐Dioxatricyclo[4.2.1.03,7]nonane‐9‐methanol and 4‐Oxatricyclo[4.3.1.03,7]decane‐10‐methanol, Compounds with Activity Against Coxsackie Viruses. (2009) (0)
The Twentieth International Conference on Antiviral Research (2007) (0)
Azapeptide activity-based probes for the SARS-CoV-2 main protease enable visualization of inhibition in infected cells (2023) (0)
Assessing the Efficacy of Small Molecule Inhibitors in aMouse Model of Persistent Norovirus Infection. (2018) (0)
A new class of dual HIV and EV71 entry inhibitors: tri and tetrapodal tryptophan derivatives (2019) (0)
Publisher Correction: A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction (2021) (0)
Antiviral activity of a novel compound P-4018 against different strains of herpes simplex virus in vitro and in vivo (1997) (0)
Faculty Opinions recommendation of Viruses are frequently present as the infecting agent in acute exacerbations of chronic obstructive pulmonary disease in patients presenting to hospital. (2017) (0)
Enterovirus Inhibition by Hinged Aromatic Compounds with Polynuclei (2020) (0)
u-PA-Gene Inactivation or TIMP-1-Gene Transfer Impairs Cardiac Injury Caused by Viral Myocarditis in Mice (2002) (0)
Synthesis and SAR of 9-Arylpurines as Novel Inhibitors of Enterovirus Replication (2009) (0)
A SCID Mouse Model To Evaluate the Efficacy of Antivirals against SARS-CoV-2 Infection (2022) (0)
Bis(Benzofuran–1,3-N,N-heterocycle)s as Symmetric and Synthetic Drug Leads against Yellow Fever Virus (2022) (0)
Synthesis, Antiviral and Cytostatic Activities of Carbocyclic Nucleosides Incorporating a Modified Cyclopentane Ring. Part 2. Adenosine and Uridine Analogues. (1998) (0)
PKCA/AP-1 Drives Transcription of Interferon-Stimulated Genes and Mediates Cell-Autonomous Defense against Hepatitis E Virus (2016) (0)
SARS-CoV-2 20I/501Y.V1 variant in the hamster model (2021) (0)
A colorimetric cell culture assay for the identification of SARS coronavirus inhibitors (2004) (0)
New Carbocyclic Nucleosides with a Constrained Bicyclo[2.2.1]Heptane Fragment as a Glycoside Moiety (2019) (0)
HCC O‐23: Outcome of patients with hepatocellular carcinoma treated with transarterial chemoembolisation (2015) (0)
A novel class of chikungunya virus inhibitors targets the enzymatic activity of the viral capping enzyme nsP1 (2015) (0)
Programs and Abstracts The Seventeenth International Conference on Antiviral Research Sponsored by : The International Society for Antiviral Research (2005) (0)
Mevastatin markedly potentiates the anti-HCV activity of selective inhibitors of HCV replication in vitro (2007) (0)
Delang L, JAC 2014 (2015) (0)
The establishment of an Enterovirus 71 (EV71) infection model with robust lethal neuro-pathogenicity in adult mice (2017) (0)
Single-dose YF17D-vectored Ebola vaccine candidate protects mice against both lethal surrogate Ebola and yellow fever virus challenge (2023) (0)
Influence of human norovirus infection on intestinal motility in zebrafish larvae (2019) (0)
P199: Mutational analysis of hepatitis E virus ORF1 ‘X‐domain’ identifies an evolutionary conserved macrodomain protein/Appr‐1''‐pase active‐site, critical for viral RNA replication in hepatoma cells (2015) (0)
Nirmatrelvir-resistant SARS-CoV-2 is efficiently transmitted in female Syrian hamsters and retains partial susceptibility to treatment (2023) (0)
Correction to 3′-Deoxy Phosphoramidate Dinucleosides as Improved Inhibitors of Hepatitis C Virus Subgenomic Replicon and NS5B Polymerase Activity (2011) (0)
Novel hydrophobic analogues inhibit flavivirus replication by targeting RNA-dependent RNA polymerase (2012) (0)
Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virus (vol 57, pg 246, 2012) (2013) (0)
In vitro and in vivo inhibition of norovirus replication by a novel class of indolylarylsulfones. (2019) (0)
SARS-CoV-2 infection causes prolonged cardiomyocyte swelling and inhibition of HIF1α translocation in an animal model COVID-19 (2022) (0)
482 IN VITRO COMBINATION THERAPY WITH TEGOBUVIR (GS-9190) IS HIGHLY EFFICIENT IN CURING CELLS FROM HCV REPLICON AND IN DELAYING/PREVENTING THE DEVELOPMENT OF ANTIVIRAL RESISTANCE (2011) (0)
P212 STEM CELL-DERIVED HEPATOCYTES AS A NOVEL IN VITRO MODEL TO STUDY HEPATOTROPIC VIRUSES (2014) (0)
Synthesis, antiviral activity, and cytotoxicity of some novel quinazolin-4 (3h)-one derivatives (2006) (0)
Faculty Opinions recommendation of A reporter cell line for rapid and sensitive evaluation of hepatitis C virus infectivity and replication. (2009) (0)
Strategies to develop novel, potent antivirals to treat chikungunya virus infections: the Leuven/SILVER experience (2013) (0)

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