Johanna Ivaska
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Finnish molecular cell biologist and professor , academy professor
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Johanna Ivaskabiology Degrees
Biology
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Cell Biology
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Molecular Biology
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Biology
Johanna Ivaska's Degrees
- PhD Cell Biology University of Turku
- Masters Biochemistry University of Turku
Why Is Johanna Ivaska Influential?
(Suggest an Edit or Addition)According to Wikipedia, Mari Johanna Ivaska is a cancer researcher and molecular cell biology academy professor in University of Turku, Finland. Early life and education Johanna Ivaska was born 1972 in Turku, Finland. Her father is emeritus analytical chemistry professor Ari Ivaska. She did her master's studies in University of Turku. Her PhD on collagen-binding integrins in University of Turku was give an honorary mention for an excellent PhD thesis by the Faculty of Medicine, University of Turku in 2001. After receiving a PhD she moved to London, UK for a postdoctoral work on investigating how integrins and protein kinases work together in cancer migration at Cancer Research UK with professor Peter J. Parker.
Johanna Ivaska's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Every step of the way: integrins in cancer progression and metastasis (2018) (740)
- Novel functions of vimentin in cell adhesion, migration, and signaling. (2007) (693)
- Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer (2011) (611)
- CIP2A Inhibits PP2A in Human Malignancies (2007) (594)
- Integrins as biomechanical sensors of the microenvironment (2019) (551)
- Filopodia in cell adhesion, 3D migration and cancer cell invasion. (2015) (357)
- Integrin-mediated Cell Adhesion to Type I Collagen Fibrils* (2004) (328)
- Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of β1-integrins (2006) (316)
- Integrin traffic – the update (2015) (268)
- Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-β–Slug signaling (2016) (251)
- Filopodia and adhesion in cancer cell motility (2011) (239)
- Internalization of Echovirus 1 in Caveolae (2002) (239)
- CIP2A Is Associated with Human Breast Cancer Aggressivity (2009) (237)
- Cooperation between integrins and growth factor receptors in signaling and endocytosis. (2011) (236)
- PKCε‐mediated phosphorylation of vimentin controls integrin recycling and motility (2005) (230)
- Integrin α2β1 Mediates Isoform-Specific Activation of p38 and Upregulation of Collagen Gene Transcription by a Mechanism Involving the α2 Cytoplasmic Tail (1999) (218)
- Distinct Recycling of Active and Inactive β1 Integrins (2012) (214)
- Clustering induces a lateral redistribution of alpha 2 beta 1 integrin from membrane rafts to caveolae and subsequent protein kinase C-dependent internalization. (2003) (202)
- Integrin trafficking in cells and tissues (2019) (201)
- Integrin traffic (2006) (201)
- Endothelial destabilization by angiopoietin-2 via integrin β1 activation (2015) (199)
- Integrin inactivators: balancing cellular functions in vitro and in vivo (2013) (198)
- Integrin trafficking regulated by Rab21 is necessary for cytokinesis. (2008) (195)
- Integrin endosomal signalling suppresses anoikis (2015) (182)
- SHARPIN is an endogenous inhibitor of β1-integrin activation (2011) (177)
- Integrin α2β1 Promotes Activation of Protein Phosphatase 2A and Dephosphorylation of Akt and Glycogen Synthase Kinase 3β (2002) (161)
- Adhesion receptors and cell invasion: mechanisms of integrin-guided degradation of extracellular matrix (2000) (160)
- PKCepsilon-mediated phosphorylation of vimentin controls integrin recycling and motility. (2005) (158)
- PKCϵ controls the traffic of β1 integrins in motile cells (2002) (153)
- Distinct Recognition of Collagen Subtypes by α1β1 and α2β1Integrins (2000) (151)
- Negative regulation of EGFR signalling through integrin-α1β1-mediated activation of protein tyrosine phosphatase TCPTP (2005) (138)
- The complexity of integrins in cancer and new scopes for therapeutic targeting (2016) (131)
- Vimentin: Central hub in EMT induction? (2011) (126)
- Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis. (2014) (126)
- L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling (2016) (124)
- SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of β1-integrin (2009) (124)
- Vimentin-ERK Signaling Uncouples Slug Gene Regulatory Function. (2015) (106)
- SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras (2017) (100)
- The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling (2012) (99)
- Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription (2016) (98)
- Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migration (2011) (95)
- The R-Ras interaction partner ORP3 regulates cell adhesion (2008) (94)
- A Peptide Inhibiting the Collagen Binding Function of Integrin α2I Domain* (1999) (91)
- Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP. (2005) (88)
- PKC epsilon controls the traffic of beta1 integrins in motile cells. (2002) (87)
- Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes (2016) (86)
- FiloQuant reveals increased filopodia density during breast cancer progression (2017) (85)
- Identification of Protein Interactions Involved in Cellular Signaling (2013) (84)
- PtdIns(3,4,5)P3 is a regulator of myosin-X localization and filopodia formation (2010) (84)
- AMPK negatively regulates tensin-dependent integrin activity (2017) (84)
- Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta. (2002) (81)
- The protein tyrosine phosphatase TCPTP controls VEGFR2 signalling (2008) (80)
- PKCɛ Regulation of an α5 Integrin–ZO-1 Complex Controls Lamellae Formation in Migrating Cancer Cells (2009) (77)
- PKCε is a permissive link in integrin-dependent IFN-γ signalling that facilitates JAK phosphorylation of STAT1 (2003) (73)
- Interplay between cell adhesion and growth factor receptors: from the plasma membrane to the endosomes (2009) (73)
- Filopodome Mapping Identifies p130Cas as a Mechanosensitive Regulator of Filopodia Stability (2018) (72)
- SHARPIN is an endogenous inhibitor of beta1-integrin activation (2011) (71)
- Cell-derived matrices for studying cell proliferation and directional migration in a complex 3D microenvironment (2017) (71)
- Differential expression of collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis. (2004) (70)
- Integrin α2I Domain Recognizes Type I and Type IV Collagens by Different Mechanisms* (2000) (69)
- Syndecan-1 supports integrin alpha2beta1-mediated adhesion to collagen. (2008) (69)
- Distinct roles of AKT isoforms in regulating β1-integrin activity, migration, and invasion in prostate cancer (2012) (68)
- Endosomes: Emerging Platforms for Integrin-Mediated FAK Signalling. (2016) (66)
- Corrigendum: Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes (2016) (65)
- OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity. (2015) (64)
- Distinct recognition of collagen subtypes by alpha(1)beta(1) and alpha(2)beta(1) integrins. Alpha(1)beta(1) mediates cell adhesion to type XIII collagen. (2000) (63)
- Integrin activity in neuronal connectivity (2018) (60)
- Mammary-derived growth inhibitor (MDGI) interacts with integrin α-subunits and suppresses integrin activity and invasion (2010) (60)
- Targeting β1-integrin inhibits vascular leakage in endotoxemia (2018) (59)
- Fetal liver endothelium regulates the seeding of tissue-resident macrophages (2016) (59)
- Tensin-4-Dependent MET Stabilization Is Essential for Survival and Proliferation in Carcinoma Cells (2014) (57)
- SHARPIN regulates uropod detachment in migrating lymphocytes. (2013) (53)
- Whom to blame for metastasis, the epithelial-mesenchymal transition or the tumor microenvironment? (2016) (52)
- A Strong Contractile Actin Fence and Large Adhesions Direct Human Pluripotent Colony Morphology and Adhesion (2017) (51)
- Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2 (2016) (51)
- Cytokinesis failure due to derailed integrin traffic induces aneuploidy and oncogenic transformation in vitro and in vivo (2011) (50)
- A phase II trial of bevacizumab with dacarbazine and daily low-dose interferon-α2a as first line treatment in metastatic melanoma (2010) (47)
- Integrin-Specific Control of Focal Adhesion Kinase and RhoA Regulates Membrane Protrusion and Invasion (2013) (46)
- A functional genetic screen reveals new regulators of β1-integrin activity (2012) (46)
- Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through α2β1 integrin and MT1-MMP. (2011) (45)
- Negative regulators of integrin activity (2012) (43)
- Epithelial vimentin plays a functional role in mammary gland development (2017) (40)
- Regulation of Cell Migration and β1 Integrin Trafficking by the Endosomal Adaptor GGA3 (2016) (39)
- SORLA regulates endosomal trafficking and oncogenic fitness of HER2 (2019) (39)
- Fluctuation-Based Super-Resolution Traction Force Microscopy (2019) (37)
- Inhibition of receptor tyrosine kinase signalling by small molecule agonist of T-cell protein tyrosine phosphatase (2010) (37)
- Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα. (2015) (35)
- Using xCELLigence RTCA Instrument to Measure Cell Adhesion. (2017) (35)
- Transcytosis route mediates rapid delivery of intact antibodies to draining lymph nodes. (2019) (34)
- Mammary-Derived Growth Inhibitor Alters Traffic of EGFR and Induces a Novel Form of Cetuximab Resistance (2009) (34)
- Distinct c-Met activation mechanisms induce cell rounding or invasion through pathways involving integrins, RhoA and HIP1 (2014) (34)
- Unanchoring integrins in focal adhesions (2012) (33)
- An RNAi screen identifies KIF15 as a novel regulator of the endocytic trafficking of integrin (2014) (33)
- SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland (2016) (33)
- “RKKH” Peptides from the Snake Venom Metalloproteinase ofBothrops jararaca Bind Near the Metal Ion-dependent Adhesion Site of the Human Integrin α2 I-domain* (1999) (32)
- A peptide inhibiting the collagen binding function of integrin alpha2I domain. (1999) (32)
- Superresolution architecture of cornerstone focal adhesions in human pluripotent stem cells (2019) (31)
- 451 Distinct Roles of AKT Isoforms in Regulating Beta1-integrin Activity, Migration and Invasion in Prostate Cancer (2012) (31)
- Cross-talk between integrins alpha1beta1 and alpha2beta1 in renal epithelial cells. (2008) (30)
- Calpains promote α2β1 integrin turnover in nonrecycling integrin pathway (2012) (29)
- Integrin-protein kinase C relationships. (2001) (29)
- Integrin signaling and mechanotransduction in regulation of somatic stem cells (2019) (28)
- Vimentin (2011) (28)
- Directed cell migration towards softer environments (2022) (28)
- PKCepsilon is a permissive link in integrin-dependent IFN-gamma signalling that facilitates JAK phosphorylation of STAT1. (2003) (27)
- Integrin alpha(2)I domain recognizes type I and type IV collagens by different mechanisms. (2000) (27)
- Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation (2018) (26)
- Tensins: Bridging AMP-Activated Protein Kinase with Integrin Activation. (2017) (24)
- Serum angiogenin levels predict treatment response in patients with stage IV melanoma (2007) (22)
- Integrins and Mutant p53 on the Road to Metastasis (2009) (21)
- Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling (2015) (21)
- Integrin adhesion complexes (2021) (21)
- Loss of ADAM9 expression impairs β1 integrin endocytosis, focal adhesion formation and cancer cell migration (2018) (21)
- Myosin-X and talin modulate integrin activity at filopodia tips (2020) (19)
- Cyt‐Geist: Current and Future Challenges in Cytometry: Reports of the CYTO 2018 Conference Workshops (2019) (19)
- GGA2 and RAB13 promote activity-dependent β1-integrin recycling (2019) (19)
- Integrin Binding Dynamics Modulate Ligand-Specific Mechanosensing in Mammary Gland Fibroblasts (2019) (18)
- Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis (2020) (16)
- Small GTPase Rab 21 regulates cell adhesion and controls endosomal traffi c of β 1-integrins (2019) (14)
- High-throughput methods in identification of protein tyrosine phosphatase inhibitors and activators. (2011) (14)
- A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance (2020) (13)
- Mutant p 53 – associated myosin-X upregulation promotes breast cancer invasion and metastasis (2014) (13)
- Mechano-responsiveness of fibrillar adhesions on stiffness-gradient gels (2019) (12)
- Vascular Morphogenesis: An Integrin and Fibronectin Highway (2017) (12)
- SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling (2021) (12)
- Molecular mechanism of T-cell protein tyrosine phosphatase (TCPTP) activation by mitoxantrone. (2013) (12)
- A ZO-1/α5β1-Integrin Complex Regulates Cytokinesis Downstream of PKCε in NCI-H460 Cells Plated on Fibronectin (2013) (12)
- Zebrafish Embryo Xenograft and Metastasis Assay. (2018) (12)
- MASTL promotes cell contractility and motility through kinase-independent signaling (2020) (12)
- Mechano-responsiveness of fibrillar adhesions on stiffness-gradient gels (2020) (11)
- Negative durotaxis: cell movement toward softer environments (2020) (10)
- ProLIF – quantitative integrin protein–protein interactions and synergistic membrane effects on proteoliposomes (2018) (10)
- 68Ga-DOTA-E[c(RGDfK)]2 PET Imaging of SHARPIN-Regulated Integrin Activity in Mice (2019) (9)
- Filopodia Quantification Using FiloQuant. (2019) (8)
- GGA2 and RAB13 regulate activity-dependent β1-integrin recycling (2018) (8)
- Talin rod domain–containing protein 1 (TLNRD1) is a novel actin-bundling protein which promotes filopodia formation (2020) (8)
- Publisher Correction: Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis (2021) (8)
- Signaling from Endosomes (2001) (7)
- A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites (2019) (7)
- Clustering induces a lateral redistribution of α 2 β 1 integrin from membrane rafts to caveolae and subsequent PKC-dependent internalization (2003) (7)
- Integrin bondage: filamin takes control (2015) (6)
- Selective Integrin Endocytosis is Driven by Alpha Chain:Ap2 Interactions (2016) (6)
- Tensin-4-Dependent MET Stabilization Is Essential for Survival and Proliferation in Carcinoma Cells (2014) (6)
- Author Correction: Every step of the way: integrins in cancer progression and metastasis (2019) (5)
- Mitosis-Resistant Adhesions Provide Molecular Memory to Dividing Cells. (2018) (5)
- Blocking integrin inactivation as an anti‐angiogenic therapy (2015) (5)
- Myosin-X is required for integrin activation at filopodia tips (2020) (4)
- Integrin “endoadhesome” signaling suppresses anoikis (2016) (4)
- Pressure Drives Rapid Burst‐Like Coordinated Cellular Motion from 3D Cancer Aggregates (2022) (4)
- Aneuploidy facilitates oncogenic transformation via specific genetic alterations, including Twist2 upregulation. (2013) (4)
- Superresolution architecture of pluripotency guarding adhesions (2018) (3)
- FiloQuant reveals increased filopodia density during DCIS progression (2017) (3)
- Upregulation of Collagen Gene Transcription by a Mechanism Involving the a 2 Cytoplasmic Tail (1999) (3)
- Food for thought: How cell adhesion coordinates nutrient sensing (2021) (3)
- Platelet SHARPIN regulates platelet adhesion and inflammatory responses through associations with αIIbβ3 and LUBAC (2022) (2)
- Integrin Binding Dynamics Modulate Ligand-Specific Mechanosensing in Mammary Gland Fibroblasts (2020) (2)
- Corrigendum to “Filopodia in cell adhesion, 3D migration and cancer cell invasion” [Curr. Opin. Cell Biol. 36 (2015) 23–31] (2015) (2)
- Meta-Analysis of Gene Expression Microarray Data: Degradome Genes in Healthy and Cancer Tissues (2008) (2)
- An extracellular receptor tyrosine kinase motif orchestrating intracellular STAT activation (2022) (2)
- Sortilin-related receptor is a druggable therapeutic target in breast cancer (2021) (2)
- MYO10-filopodia support basement membranes at pre-invasive tumor boundaries. (2022) (2)
- 485 Distinct Recycling of Active and Inactive 1 Integrins (2012) (2)
- Conformational dynamics regulate SHANK3 actin and Rap1 binding (2020) (2)
- Myosin-X recruits lamellipodin to filopodia tips (2022) (2)
- PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancers (2019) (2)
- ProLIF: a quantitative assay for investigating integrin cytoplasmic protein interactions and synergistic membrane effects on proteoliposomes (2017) (2)
- Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting (2020) (2)
- Myosin-X-dependent assembly of the extracellular matrix limits breast cancer invasion (2021) (1)
- Sortilin‐related receptor is a druggable therapeutic target in breast cancer (2021) (1)
- Laminin alpha 5 is Necessary for Mammary Epithelial Growth and Function by Maintaining Luminal Epithelial Cell Identity (2019) (1)
- Abstract B29: SHANK3 in oncogenic RAS signaling (2020) (1)
- ""RKKH"" PEPTIDES FROM THE SNAKE VENOM METALLOPROTEINASE OF BOTHROPS JARARACA BIND NEAR THE MIDAS SITE OF THE HUMAN INTEGRIN ALPHA2 I-DOMAIN (1999) (1)
- Editorial overview: Cell architecture: Integrating physics and chemistry in emergent cellular properties. (2019) (1)
- ZeroCostDL4Mic - Noise2Void (2D) example training and test dataset (2020) (1)
- Vimentin plays a functional role in mammary gland regeneration (2017) (1)
- SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras (2017) (1)
- Phosphoproteomic Analysis of DNA Damage Checkpoint Kinase Signaling Reveals Unexpected Links to Actin Cytoskeletal Remodeling, Cell Migration, and Chemoresistance (2017) (1)
- SORLA regulates endosomal trafficking and oncogenic fitness of HER2 (2019) (0)
- SorLA Targeting - A Method to Overcome Therapy Resistance in Breast Cancer (2021) (0)
- Integrin-peptide and its use (1998) (0)
- PKC e controls the traf ® c of b 1 integrins in motile cells (0)
- Identification of sharpin as a molecule regulating leukocyte transmigration from siRNA screens (LB281) (2014) (0)
- Pressure Drives Rapid Burst‐Like Coordinated Cellular Motion from 3D Cancer Aggregates (Adv. Sci. 6/2022) (2022) (0)
- Specialized actin nanoscale layers control focal adhesion turnover (2023) (0)
- Selective integrin endocytosis is driven by α chain:AP2 interactions (2015) (0)
- Author Correction: Every step of the way: integrins in cancer progression and metastasis (2019) (0)
- SORLA-driven endosomal trafficking regulates the oncogenic fitness of HER2 (2018) (0)
- Integrin-Rab21-Rasa1 complex regulates integrin traffic in migrating cells (2008) (0)
- Corrigendum. (2019) (0)
- Fatty acid binding proteins (FABPs) as modulators of integrin function in breast cancer cells (2007) (0)
- Abstract P3-05-08: Sortilin-related receptor regulates receptor tyrosine kinase traffic and signaling (2020) (0)
- Erratum: Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2 (2017) (0)
- Expression of mammary derived growth inhibitor (MDGI) results in phenotypic reversal in breast cancer (2008) (0)
- Formin-like 2 Promotes b 1-Integrin Trafficking and Invasive Motility Downstream of PKC a Highlights (0)
- Filopodia-mediated basement membrane assembly at pre-invasive tumor boundaries (2022) (0)
- Targeting a broad spectrum of KRAS-mutant cancers by hyperactivation-induced cell death (2022) (0)
- Integrins as biomechanical sensors of the microenvironment (2019) (0)
- Abstract 4888: Axl receptor signaling in required for stem cell traits and metastasis in breast cancer. (2013) (0)
- Abstract C76: Axl signaling is required for stem cell traits and metastasis in breast cancer (2013) (0)
- KATRI KÖNINKI HER-2 Positive Breast Cancer (2010) (0)
- Regulation of cell dynamics by rapid transport of integrins through the biosynthetic pathway (2022) (0)
- Integrin trafficking in cells and tissues (2019) (0)
- Cell Adhesion to Collagen-Is One Collagen Receptor Different from Another? (1998) (0)
- Abstract 3486: Combined inhibition of tumor suppressors PTEN and PP2A drives anoikis resistance and is associated with therapy relapse in prostate cancer (2019) (0)
- MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels (2022) (0)
- Abstract 5067: b1-Integrin promotes inflammatory cytokine-induced vascular leakage (2018) (0)
- Filopodia-Mediated Basement Membrane Assembly at Tumor Boundaries (2022) (0)
- Serum angiogenin level predict treatment response and survival in patients with stage IV melanoma (2006) (0)
- Abstract 3308: Axl is required for EMT-induced stem cell traits and metastasis in breast cancer (2012) (0)
- AXL-TBK1 driven nuclear AKT3 promotes metastasis (2022) (0)
- Every step of the way: integrins in cancer progression and metastasis (2018) (0)
- 681 Aneuploidy Facilitates Oncogenic Transformation Via Specific Genetic Alterations (2012) (0)
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What Schools Are Affiliated With Johanna Ivaska?
Johanna Ivaska is affiliated with the following schools:
