Johanne Martel-Pelletier

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#1582

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#117

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#149

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Why Is Johanne Martel-Pelletier Influential?

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According to Wikipedia, Johanne Martel-Pelletier is a Canadian pharmacologist living and working in Quebec. She studies the pathophysiology and molecular mechanisms of arthritis. She was born in Saint-Jean-sur-Richelieu. She earned a master's degree and doctorate in physiology from the University of Montreal. She continued with post-graduate studies in biophysics at the University of Montreal and in rheumatology at the University of Miami. In 1981, she was named assistant professor of medicine at the University of Montreal; in 1995, she became a full professor.

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Johanne Martel-Pelletier's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis (2011) (1948)
Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets. (2001) (1076)
IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages. (1998) (1046)
The role of cytokines in osteoarthritis pathophysiology. (2002) (1026)
Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage. (1989) (613)
Cartilage in normal and osteoarthritis conditions. (2008) (529)
The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis. (1996) (502)
Meniscal tear and extrusion are strongly associated with progression of symptomatic knee osteoarthritis as assessed by quantitative magnetic resonance imaging (2004) (484)
Safety and efficacy of long-term intraarticular steroid injections in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled trial. (2003) (464)
An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: a report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). (2014) (437)
Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs (2003) (378)
In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy. (1997) (360)
Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression. (1996) (360)
Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase. (1998) (344)
Cyclooxygenase-2 and prostaglandins in articular tissues. (2003) (327)
Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis (2014) (311)
An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). (2019) (294)
Excess of metalloproteases over tissue inhibitor of metalloprotease may contribute to cartilage degradation in osteoarthritis and rheumatoid arthritis. (1994) (291)
Value of biomarkers in osteoarthritis: current status and perspectives (2013) (286)
Quantitative magnetic resonance imaging evaluation of knee osteoarthritis progression over two years and correlation with clinical symptoms and radiologic changes. (2004) (274)
Metalloproteases and inhibitors in arthritic diseases. (2001) (272)
Cytokines and their role in the pathophysiology of osteoarthritis. (1999) (264)
Long term evaluation of disease progression through the quantitative magnetic resonance imaging of symptomatic knee osteoarthritis patients: correlation with clinical symptoms and radiographic changes (2005) (253)
Selective inhibition of inducible nitric oxide synthase reduces progression of experimental osteoarthritis in vivo: possible link with the reduction in chondrocyte apoptosis and caspase 3 level. (2000) (246)
In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression. (1999) (239)
Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes (2009) (227)
Risk factors associated with the loss of cartilage volume on weight-bearing areas in knee osteoarthritis patients assessed by quantitative magnetic resonance imaging: a longitudinal study (2007) (222)
Osteoblast-like cells from human subchondral osteoarthritic bone demonstrate an altered phenotype in vitro: possible role in subchondral bone sclerosis. (1998) (220)
A consensus statement on the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) algorithm for the management of knee osteoarthritis-From evidence-based medicine to the real-life setting. (2016) (219)
Pathophysiology of osteoarthritis. (1998) (216)
Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib (2015) (216)
Peroxisome proliferator--activated receptor gamma activators inhibit interleukin-1beta-induced nitric oxide and matrix metalloproteinase 13 production in human chondrocytes. (2001) (203)
Human osteoarthritic chondrocytes possess an increased number of insulin-like growth factor 1 binding sites but are unresponsive to its stimulation. Possible role of IGF-1-binding proteins. (1994) (201)
The Induction of Cell Death in Human Osteoarthritis Chondrocytes by Nitric Oxide Is Related to the Production of Prostaglandin E2 Via the Induction of Cyclooxygenase-2 (2000) (201)
Cytokines and inflammation in cartilage degradation. (1993) (199)
Stimulation of 92-kd gelatinase (matrix metalloproteinase 9) production by interleukin-17 in human monocyte/macrophages: a possible role in rheumatoid arthritis. (2000) (194)
Collagenase-3 (matrix metalloprotease 13) is preferentially localized in the deep layer of human arthritic cartilage in situ: in vitro mimicking effect by transforming growth factor beta. (1997) (191)
Can altered production of interleukin-1beta, interleukin-6, transforming growth factor-beta and prostaglandin E(2) by isolated human subchondral osteoblasts identify two subgroups of osteoarthritic patients. (2002) (187)
Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI (2011) (185)
The interleukin-1 receptor in normal and osteoarthritic human articular chondrocytes. Identification as the type I receptor and analysis of binding kinetics and biologic function. (1992) (181)
PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage (2015) (179)
Correlation between bone lesion changes and cartilage volume loss in patients with osteoarthritis of the knee as assessed by quantitative magnetic resonance imaging over a 24-month period (2007) (177)
Targeting subchondral bone for treating osteoarthritis: what is the evidence? (2010) (176)
The increased synthesis of inducible nitric oxide inhibits IL-1ra synthesis by human articular chondrocytes: possible role in osteoarthritic cartilage degradation. (1996) (167)
Collagenase and collagenolytic activity in human osteoarthritic cartilage. (1983) (163)
Synovial membrane histology and immunopathology in rheumatoid arthritis and osteoarthritis. In vivo effects of antirheumatic drugs. (1991) (163)
Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors. (1999) (162)
IGF/IGFBP axis in cartilage and bone in osteoarthritis pathogenesis (1998) (159)
Protective effects of corticosteroids on cartilage lesions and osteophyte formation in the Pond-Nuki dog model of osteoarthritis. (1989) (158)
The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K. (2004) (156)
Meniscal tear as an osteoarthritis risk factor in a largely non-osteoarthritic cohort: a cross-sectional study. (2007) (155)
Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI (2008) (155)
Neutral proteases capable of proteoglycan digesting activity in osteoarthritic and normal human articular cartilage. (1984) (154)
Reliability of a quantification imaging system using magnetic resonance images to measure cartilage thickness and volume in human normal and osteoarthritic knees. (2003) (153)
Mitogen‐activated protein kinase and nuclear factor κB together regulate interleukin‐17–induced nitric oxide production in human osteoarthritic chondrocytes: Possible role of transactivating factor mitogen–activated protein kinase–activated protein kinase (MAPKAPK) (1999) (150)
Are cytokines involved in osteoarthritic pathophysiology? (1991) (146)
Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes. (2008) (145)
Collagenolytic activity and collagen matrix breakdown of the articular cartilage in the Pond-Nuki dog model of osteoarthritis. (1983) (145)
Computer-aided method for quantification of cartilage thickness and volume changes using MRI: validation study using a synthetic model (2003) (143)
Interleukin-1beta-converting enzyme/caspase-1 in human osteoarthritic tissues: localization and role in the maturation of interleukin-1beta and interleukin-18. (1999) (143)
Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production. (2009) (142)
Imbalance between the mechanisms of activation and inhibition of metalloproteases in the early lesions of experimental osteoarthritis. (1990) (137)
Efficacy and safety of topical NSAIDs in the management of osteoarthritis: Evidence from real-life setting trials and surveys. (2016) (137)
Intraarticular injections with methylprednisolone acetate reduce osteoarthritic lesions in parallel with chondrocyte stromelysin synthesis in experimental osteoarthritis. (1994) (135)
Is osteoarthritis a disease involving only cartilage or other articular tissues? (2010) (131)
Inhibition of tumor necrosis factor alpha-induced prostaglandin E2 production by the antiinflammatory cytokines interleukin-4, interleukin-10, and interleukin-13 in osteoarthritic synovial fibroblasts: distinct targeting in the signaling pathways. (1999) (129)
Role of synovial membrane inflammation in cartilage matrix breakdown in the Pond-Nuki dog model of osteoarthritis. (1985) (124)
Coordinate synthesis of stromelysin, interleukin-1, and oncogene proteins in experimental osteoarthritis. An immunohistochemical study. (1993) (123)
Collagenase-1 and collagenase-3 synthesis in normal and early experimental osteoarthritic canine cartilage: an immunohistochemical study. (1998) (119)
Interleukin 17 (IL-17) induces collagenase-3 production in human osteoarthritic chondrocytes via AP-1 dependent activation: differential activation of AP-1 members by IL-17 and IL-1beta. (2002) (118)
In vivo selective inhibition of mitogen-activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes. (2003) (118)
Efficacy and safety of oral NSAIDs and analgesics in the management of osteoarthritis: Evidence from real-life setting trials and surveys. (2016) (117)
Biochemical basis of the effect of chondroitin sulphate on osteoarthritis articular tissues (2007) (112)
A Phase II Trial of Lutikizumab, an Anti–Interleukin‐1α/β Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis (2019) (111)
Knee meniscal extrusion in a largely non-osteoarthritic cohort: association with greater loss of cartilage volume (2007) (111)
Meniscal extrusion predicts increases in subchondral bone marrow lesions and bone cysts and expansion of subchondral bone in osteoarthritic knees. (2010) (110)
In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: suppression of collagenase 1 and interleukin-1beta synthesis. (2001) (108)
The in vivo effects of intraarticular corticosteroid injections on cartilage lesions, stromelysin, interleukin-1, and oncogene protein synthesis in experimental osteoarthritis. (1995) (107)
Activation of Peroxisome Proliferator-activated Receptor γ Inhibits Interleukin-1β-induced Membrane-associated Prostaglandin E2 Synthase-1 Expression in Human Synovial Fibroblasts by Interfering with Egr-1* (2004) (107)
Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13 (2009) (107)
The pathophysiology of osteoarthritis and the implication of the use of hyaluronan and hylan as therapeutic agents in viscosupplementation. (1993) (106)
Strontium ranelate inhibits key factors affecting bone remodeling in human osteoarthritic subchondral bone osteoblasts. (2011) (106)
In vitro effects of diacerhein and rhein on interleukin 1 and tumor necrosis factor-alpha systems in human osteoarthritic synovium and chondrocytes. (1998) (106)
Automatic Human Knee Cartilage Segmentation From 3-D Magnetic Resonance Images (2010) (105)
Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science study (2007) (105)
Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults (2010) (103)
New perspective in osteoarthritis: the OPG and RANKL system as a potential therapeutic target? (2009) (103)
OARSI Clinical Trials Recommendations: Knee imaging in clinical trials in osteoarthritis. (2015) (103)
Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis. (2009) (102)
Decrease in serum level of matrix metalloproteinases is predictive of the disease-modifying effect of osteoarthritis drugs assessed by quantitative MRI in patients with knee osteoarthritis (2010) (102)
Chondrocyte death in experimental osteoarthritis is mediated by MEK 1/2 and p38 pathways: role of cyclooxygenase-2 and inducible nitric oxide synthase. (2001) (101)
Risk factors predictive of joint replacement in a 2-year multicentre clinical trial in knee osteoarthritis using MRI: results from over 6 years of observation (2011) (101)
Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes (2004) (101)
The differential expression of osteoprotegerin (OPG) and receptor activator of nuclear factor kappaB ligand (RANKL) in human osteoarthritic subchondral bone osteoblasts is an indicator of the metabolic state of these disease cells. (2008) (101)
The association between objectively measured physical activity and knee structural change using MRI (2012) (100)
IL-17 Stimulates the Production and Expression of Proinflammatory Cytokines, IL-β and TNF-α, by Human Macrophages (1998) (100)
Pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, reduces the progression of experimental osteoarthritis in guinea pigs. (2005) (99)
A new non-invasive method to assess synovitis severity in relation to symptoms and cartilage volume loss in knee osteoarthritis patients using MRI. (2008) (99)
The association between subchondral bone cysts and tibial cartilage volume and risk of joint replacement in people with knee osteoarthritis: a longitudinal study (2010) (98)
Future therapeutics for osteoarthritis. (2012) (98)
Diacerhein and rhein reduce the interleukin 1beta stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes. (1998) (98)
Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site (2006) (98)
Diacerein: Benefits, Risks and Place in the Management of Osteoarthritis. An Opinion-Based Report from the ESCEO (2016) (98)
Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model (2011) (98)
Plasmin, plasminogen activators and inhibitor in human osteoarthritic cartilage. (1991) (94)
First-line analysis of the effects of treatment on progression of structural changes in knee osteoarthritis over 24 months: data from the osteoarthritis initiative progression cohort. (2015) (92)
What is the predictive value of MRI for the occurrence of knee replacement surgery in knee osteoarthritis? (2013) (92)
Disease-modifying effect of strontium ranelate in a subset of patients from the Phase III knee osteoarthritis study SEKOIA using quantitative MRI: reduction in bone marrow lesions protects against cartilage loss (2013) (92)
Machine-learning-based patient-specific prediction models for knee osteoarthritis (2018) (91)
Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts (2004) (90)
Normal expression of type 1 insulin-like growth factor receptor by human osteoarthritic chondrocytes with increased expression and synthesis of insulin-like growth factor binding proteins. (1996) (90)
Transcriptional induction of cyclooxygenase‐2 gene by okadaic acid inhibition of phosphatase activity in human chondrocytes: Co‐stimulation of AP‐1 and CRE nuclear binding proteins (1998) (90)
Synthesis of metalloproteases and interleukin 6 (IL-6) in human osteoarthritic synovial membrane is an IL-1 mediated process. (1995) (89)
Diacerhein and rhein reduce the ICE-induced IL-1beta and IL-18 activation in human osteoarthritic cartilage. (2000) (89)
OARSI Clinical Trials Recommendations: Hip imaging in clinical trials in osteoarthritis. (2015) (88)
High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes (2010) (87)
Characterization of osteoarthritis in cats and meloxicam efficacy using objective chronic pain evaluation tools. (2013) (85)
Collagenase 3 production by human osteoarthritic chondrocytes in response to growth factors and cytokines is a function of the physiologic state of the cells. (1999) (84)
How to define responders in osteoarthritis (2013) (82)
PPARgamma ligands as modulators of inflammatory and catabolic responses in arthritis. An overview. (2002) (81)
ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis (2017) (81)
Peroxisome proliferator-activated receptor gamma activators inhibit MMP-1 production in human synovial fibroblasts likely by reducing the binding of the activator protein 1. (2002) (81)
Synthesis of interleukin 1beta, tumor necrosis factor-alpha, and interstitial collagenase (MMP-1) is eicosanoid dependent in human osteoarthritis synovial membrane explants: interactions with antiinflammatory cytokines. (2002) (81)
Carprofen simultaneously reduces progression of morphological changes in cartilage and subchondral bone in experimental dog osteoarthritis. (2000) (80)
Osteoarthritic synovial fibroblasts possess an increased level of tumor necrosis factor-receptor 55 (TNF-R55) that mediates biological activation by TNF-alpha. (1997) (80)
Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. The increased level of the IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor. (1995) (79)
Discrepancies in Composition and Biological Effects of Different Formulations of Chondroitin Sulfate (2015) (79)
In vitro effects of interleukin 1 on the synthesis of metalloproteases, TIMP, plasminogen activators and inhibitors in human articular cartilage. (1991) (79)
Glucocorticoid receptor mediated inhibition of interleukin-1 stimulated neutral metalloprotease synthesis in normal human chondrocytes. (1991) (78)
Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1β in the synovium (2012) (78)
Ten years in the life of an enzyme: the story of the human MMP-13 (collagenase-3) (2004) (77)
Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow (2006) (76)
Galectin-3 surface expression on human adult chondrocytes: a potential substrate for collagenase-3 (2004) (76)
Contribution of H3K4 methylation by SET-1A to interleukin-1-induced cyclooxygenase 2 and inducible nitric oxide synthase expression in human osteoarthritis chondrocytes. (2011) (76)
Prostaglandins E2 and E1 inhibit cytokine-induced metalloprotease expression in human synovial fibroblasts. Mediation by cyclic-AMP signalling pathway. (1994) (75)
The peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of osteoarthritis: in vivo protective effects mediated through the inhibition of key signaling and catabolic pathways. (2007) (75)
Peroxisome proliferator-activated receptor γ1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1β in articular chondrocytes (2007) (75)
Peroxisome proliferator-activated receptor gamma in osteoarthritis (2011) (73)
Human Adult Chondrocytes Express Hepatocyte Growth Factor (HGF) Isoforms but Not HGF: Potential Implication of Osteoblasts on the Presence of HGF in Cartilage (2003) (73)
Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition. (2002) (73)
OARSI Clinical Trials Recommendations: Design and conduct of clinical trials for hand osteoarthritis. (2015) (72)
IGF and IGF-binding protein system in the synovial fluid of osteoarthritic and rheumatoid arthritic patients. (1996) (72)
The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases (2005) (71)
Effects of diacerein at the molecular level in the osteoarthritis disease process (2010) (70)
Evidence for the involvement of interleukin 1 in human osteoarthritic cartilage degradation: protective effect of NSAID. (1989) (70)
Effects of tenidap on canine experimental osteoarthritis. I. Morphologic and metalloprotease analysis. (1995) (69)
Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B(4) in osteoarthritic chondrocytes: role of transforming growth factor beta and eicosanoids. (2004) (69)
Abnormal regulation of urokinase plasminogen activator by insulin-like growth factor 1 in human osteoarthritic subchondral osteoblasts. (1999) (68)
Cloning, sequencing and characterization of the 5'-flanking region of the human collagenase-3 gene. (1997) (67)
Endogenous Prostaglandin E2 and Insulin‐like Growth Factor 1 Can Modulate the Levels of Parathyroid Hormone Receptor in Human Osteoarthritic Osteoblasts (2001) (67)
Nitric oxide induced cell death in human osteoarthritic synoviocytes is mediated by tyrosine kinase activation and hydrogen peroxide and/or superoxide formation. (2002) (67)
Relationship between bone marrow lesions, cartilage loss and pain in knee osteoarthritis: results from a randomised controlled clinical trial using MRI (2010) (67)
The in situ up-regulation of chondrocyte interleukin-1-converting enzyme and interleukin-18 levels in experimental osteoarthritis is mediated by nitric oxide. (2002) (67)
Mitogen-activated protein kinase and nuclear factor kappaB together regulate interleukin-17-induced nitric oxide production in human osteoarthritic chondrocytes: possible role of transactivating factor mitogen-activated protein kinase-activated proten kinase (MAPKAPK). (1999) (66)
Adult cartilage-specific peroxisome proliferator-activated receptor gamma knockout mice exhibit the spontaneous osteoarthritis phenotype. (2013) (66)
Osteophytosis, subchondral bone sclerosis, joint effusion and soft tissue thickening in canine experimental stifle osteoarthritis: comparison between 1.5 T magnetic resonance imaging and computed radiography. (2008) (65)
Two-year prospective longitudinal study exploring the factors associated with change in femoral cartilage volume in a cohort largely without knee radiographic osteoarthritis. (2008) (65)
Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study (2007) (63)
NFAT3 and TGF-β/SMAD3 regulate the expression of miR-140 in osteoarthritis (2013) (63)
Modulation of insulin-like growth factor 1 levels in human osteoarthritic subchondral bone osteoblasts. (2006) (63)
Proteoglycan-degrading acid metalloprotease activity in human osteoarthritic cartilage, and the effect of intraarticular steroid injections. (1987) (63)
Effects of chondroitin sulfate in the pathophysiology of the osteoarthritic joint: a narrative review. (2010) (62)
Expression of the tissue inhibitor of metalloproteinases (TIMP) gene family in normal and osteoarthritic joints (1999) (62)
Levels of metalloproteases and tissue inhibitor of metalloproteases in human osteoarthritic cartilage. (1987) (61)
Oral treatment with PD-0200347, an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes. (2005) (61)
Inhibition of interleukin-1beta-induced matrix metalloproteinases 1 and 13 production in human osteoarthritic chondrocytes by prostaglandin D2. (2008) (60)
DMOAD developments: present and future. (2007) (59)
Low sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/β-catenin activity. (2014) (59)
Modulation of matrix metalloprotease 13 (collagenase 3) gene expression in equine chondrocytes by interleukin 1 and corticosteroids. (1996) (59)
Modulation of TIMP-1 synthesis by antiinflammatory cytokines and prostaglandin E2 in interleukin 17 stimulated human monocytes/macrophages. (2001) (57)
Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling (2008) (57)
Coordinate regulation of matrix metalloproteases and tissue inhibitor of metalloproteinase expression in human synovial fibroblasts. (1995) (57)
Elevated metalloproteinase and tissue inhibitor of metalloproteinase mRNA in human osteoarthritic synovia. (1993) (56)
Effect of IL-13 on cytokines, cytokine receptors and inhibitors on human osteoarthritis synovium and synovial fibroblasts. (1998) (56)
The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway (2004) (55)
Association between metformin use and disease progression in obese people with knee osteoarthritis: data from the Osteoarthritis Initiative—a prospective cohort study (2019) (55)
Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: influence of osteotropic factors. (2008) (54)
Magnetic resonance imaging can accurately assess the long-term progression of knee structural changes in experimental dog osteoarthritis (2007) (53)
Association of cartilage-specific deletion of peroxisome proliferator-activated receptor γ with abnormal endochondral ossification and impaired cartilage growth and development in a murine model. (2012) (53)
Subchondral bone morphological and biochemical alterations in osteoarthritis. (1999) (53)
Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis. (2005) (52)
Biochemical Factors in Joint Articular Tissue Degradation in Osteoarthritis (1999) (51)
15d-PGJ(2) is acting as a 'dual agent' on the regulation of COX-2 expression in human osteoarthritic chondrocytes. (2002) (51)
Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism. (2005) (51)
Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts (2006) (51)
The levels of the adipokines adipsin and leptin are associated with knee osteoarthritis progression as assessed by MRI and incidence of total knee replacement in symptomatic osteoarthritis patients: a post hoc analysis. (2016) (50)
Evaluation of osteoarthritis in cats: novel information from a pilot study. (2012) (50)
Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts. (2008) (50)
A fully automated human knee 3D MRI bone segmentation using the ray casting technique (2011) (50)
Hepatocyte growth factor induction of collagenase 3 production in human osteoarthritic cartilage: involvement of the stress-activated protein kinase/c-Jun N-terminal kinase pathway and a sensitive p38 mitogen-activated protein kinase inhibitor cascade. (2001) (49)
Intra-articular hyaluronic acid in the treatment of knee osteoarthritis: a Canadian evidence-based perspective (2017) (49)
Clinical validity of outcome pain measures in naturally occurring canine osteoarthritis (2012) (49)
Republished: Value of biomarkers in osteoarthritis: current status and perspectives (2013) (49)
Alternative and complementary therapies in osteoarthritis and cartilage repair (2020) (49)
Human Hip Joint Cartilage: MRI Quantitative Thickness and Volume Measurements Discriminating Acetabulum and Femoral Head (2008) (49)
In vivo protective effects of prophylactic treatment with tiaprofenic acid or intraarticular corticosteroids on osteoarthritic lesions in the experimental dog model. (1991) (48)
Differential effects of IL-8, LIF (pro-inflammatory) and IL-11 (anti-inflammatory) on TNF-alpha-induced PGE(2)release and on signalling pathways in human OA synovial fibroblasts. (1999) (48)
Modulation of glucocorticoid receptor expression in human articular chondrocytes by cAMP and prostaglandins. (1991) (48)
NTP pyrophosphohydrolase in human chondrocalcinotic and osteoarthritic cartilage. II. Further studies on histologic and subcellular distribution. (1984) (48)
Endothelin 1 promotes osteoarthritic cartilage degradation via matrix metalloprotease 1 and matrix metalloprotease 13 induction. (2003) (48)
Cartilage degradation by neutral proteoglycanases in experimental osteoarthritis. Suppression by steroids. (1985) (48)
Subchondral bone sclerosis in osteoarthritis: not just an innocent bystander (2003) (48)
Cardiovascular adverse effects of anti-inflammatory drugs. (2013) (47)
The presence of meniscal lesions is a strong predictor of neuropathic pain in symptomatic knee osteoarthritis: a cross-sectional pilot study (2014) (47)
Reduction in the structural changes of experimental osteoarthritis by a nitric oxide inhibitor. (1999) (47)
Variable Effects of 3 Different Chondroitin Sulfate Compounds on Human Osteoarthritic Cartilage/Chondrocytes: Relevance of Purity and Production Process (2010) (47)
Superiority of the gastroduodenal safety profile of licofelone over rofecoxib, a COX-2 selective inhibitor, in dogs. (2005) (47)
Wanted--the collagenase responsible for the destruction of the collagen network in human cartilage! (1996) (47)
PD-0200347, an α2δ ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCα dependent effect (2005) (46)
Canine osteoarthritis: Effects of endogenous neutral metalloproteoglycanases on articular cartilage proteoglycans (1988) (46)
Subchondral and trabecular bone metabolism regulation in canine experimental knee osteoarthritis. (2005) (46)
Meniscal extrusion and bone marrow lesions are associated with incident and progressive knee osteoarthritis. (2017) (46)
Cathepsin B and cysteine protease inhibitors in human osteoarthritis (1990) (45)
Chondroitin sulfate efficacy versus celecoxib on knee osteoarthritis structural changes using magnetic resonance imaging: a 2-year multicentre exploratory study (2016) (45)
Prostaglandin E2 stimulates insulin‐like growth factor binding protein‐4 expression and synthesis in cultured human articular chondrocytes: Possible mediation by Ca++ ‐calmodulin regulated processes (1997) (45)
Activation of neutral metalloprotease in human osteoarthritic knee cartilage: evidence for degradation in the core protein of sulphated proteoglycan. (1988) (44)
Efficacy of licofelone in dogs with clinical osteoarthritis (2007) (44)
Transforming growth factor-beta induced collagenase-3 production in human osteoarthritic chondrocytes is triggered by Smad proteins: cooperation between activator protein-1 and PEA-3 binding sites. (2001) (44)
In vitro effects of tiaprofenic acid, sodium salicylate and hydrocortisone on the proteoglycan metabolism of human osteoarthritic cartilage. (1989) (44)
Proteinase-activated Receptor-2 Gene Disruption Limits the Effect of Osteoarthritis on Cartilage in Mice: A Novel Target in Joint Degradation (2011) (44)
Licofelone (ML-3000), a dual inhibitor of 5-lipoxygenase and cyclooxygenase, reduces the level of cartilage chondrocyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factors. (2002) (42)
Alteration of Wnt5a expression and of the non-canonical Wnt/PCP and Wnt/PKC-Ca2+ pathways in human osteoarthritis osteoblasts (2017) (42)
The BMP antagonists follistatin and gremlin in normal and early osteoarthritic cartilage: an immunohistochemical study. (2009) (42)
The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein (2006) (41)
New thoughts on the pathophysiology of osteoarthritis: One more step toward new therapeutic targets (2006) (40)
Elucidating the Role of Protandim and 6‐Gingerol in Protection Against Osteoarthritis (2017) (40)
Identification of opticin, a member of the small leucine-rich repeat proteoglycan family, in human articular tissues: a novel target for MMP-13 in osteoarthritis. (2008) (40)
Hyaluronic acid reverses the abnormal synthetic activity of human osteoarthritic subchondral bone osteoblasts. (2003) (40)
The unfolded protein response genes in human osteoarthritic chondrocytes: PERK emerges as a potential therapeutic target (2016) (40)
Prostaglandin E2 stimulates incorporation of proline into collagenase digestible proteins in human articular chondrocytes: identification of an effector autocrine loop involving insulin-like growth factor I (1996) (40)
Diacerein reduces the excess synthesis of bone remodeling factors by human osteoblast cells from osteoarthritic subchondral bone. (2001) (39)
Regulation of human normal and osteoarthritic chondrocyte interleukin-1 receptor by antirheumatic drugs. (1993) (39)
Interleukin 17, a nitric oxide-producing cytokine with a peroxynitrite-independent inhibitory effect on proteoglycan synthesis. (2002) (39)
Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis (2003) (39)
Fully automated system for the quantification of human osteoarthritic knee joint effusion volume using magnetic resonance imaging (2010) (39)
Reduced expression of glucocorticoid receptor levels in human osteoarthritic chondrocytes. Role in the suppression of metalloprotease synthesis. (1993) (39)
Levels of serum biomarkers from a two-year multicentre trial are associated with treatment response on knee osteoarthritis cartilage loss as assessed by magnetic resonance imaging: an exploratory study (2017) (38)
An open-label pilot study evaluating by magnetic resonance imaging the potential for a disease-modifying effect of celecoxib compared to a modelized historical control cohort in the treatment of knee osteoarthritis. (2010) (38)
Two NSAIDs, nimesulide and naproxen, can reduce the synthesis of urokinase and IL-6 while increasing PAI-1, in human OA synovial fibroblasts. (1997) (38)
Therapeutic targets in osteoarthritis: from today to tomorrow with new imaging technology (2003) (38)
Effect of Intravenous Zoledronic Acid on Tibiofemoral Cartilage Volume Among Patients With Knee Osteoarthritis With Bone Marrow Lesions: A Randomized Clinical Trial. (2020) (37)
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Intracellular localisation of galectin-3 has a protective role in chondrocyte survival (2007) (36)
Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts. (2009) (36)
Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes (2009) (36)
Extracellular localization of galectin-3 has a deleterious role in joint tissues (2007) (36)
Expression of c‐fos, c‐jun, jun‐B, metallothionein and metalloproteinase genes in human chondrocyte (1992) (36)
Increased insulin-like growth factor 1 production by human osteoarthritic chondrocytes is not dependent on growth hormone action. (1995) (35)
In vivo bone-specific EphB4 overexpression in mice protects both subchondral bone and cartilage during osteoarthritis. (2012) (35)
Analysis of the precision and sensitivity to change of different approaches to assess cartilage loss by quantitative MRI in a longitudinal multicentre clinical trial in patients with knee osteoarthritis (2008) (34)
The longitudinal relationship between changes in body weight and changes in medial tibial cartilage, and pain among community-based adults with and without meniscal tears (2013) (34)
R-spondins are newly recognized players in osteoarthritis that regulate Wnt signaling in osteoblasts. (2011) (34)
Knee pain as a predictor of structural progression over 4 years: data from the Osteoarthritis Initiative, a prospective cohort study (2018) (34)
A reference case for economic evaluations in osteoarthritis: an expert consensus article from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). (2014) (33)
Analgesic efficacy of tramadol in cats with naturally occurring osteoarthritis (2017) (33)
Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism. (2002) (32)
Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and upregulates collagenase production (2005) (32)
The synthesis of IL-1 receptor antagonist (IL-1ra) by synovial fibroblasts is markedly increased by the cytokines TNF-alpha and IL-1. (1993) (32)
Immunological analysis of proteoglycan structural changes in the early stage of experimental osteoarthritic canine cartilage lesions (1992) (31)
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Neutral proteases in human osteoarthritic synovium. (1986) (31)
Modulation of collagenase 3 in human osteoarthritic cartilage by activation of extracellular transforming growth factor β: Role of furin convertase (2000) (31)
Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1β-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes (2014) (31)
Oncostatin M: foe or friend? (2003) (31)
Analgesic efficacy of an oral transmucosal spray formulation of meloxicam alone or in combination with tramadol in cats with naturally occurring osteoarthritis. (2016) (31)
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Association between meniscal tears and the peak external knee adduction moment and foot rotation during level walking in postmenopausal women without knee osteoarthritis: a cross-sectional study (2008) (30)
Chondroitin sulphate for symptomatic osteoarthritis: critical appraisal of meta-analyses (2008) (30)
Diacerein reduces the level of cartilage chondrocyte DNA fragmentation and death in experimental dog osteoarthritic cartilage at the same time that it inhibits caspase-3 and inducible nitric oxide synthase. (2003) (30)
Human rheumatoid arthritic cartilage and its neutral proteoglycan-degrading proteases. The effects of antirheumatic drugs. (1985) (29)
Evoked Temporal Summation in Cats to Highlight Central Sensitization Related to Osteoarthritis-Associated Chronic Pain: A Preliminary Study (2014) (29)
Activation of The Phosphatidylcholine to Lysophosphatidylcholine Pathway Is Associated with Osteoarthritis Knee Cartilage Volume Loss Over Time (2019) (29)
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Long‐Term Effects of Glucosamine and Chondroitin Sulfate on the Progression of Structural Changes in Knee Osteoarthritis: Six‐Year Followup Data From the Osteoarthritis Initiative (2016) (28)
PD-0200347, an alpha2delta ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCalpha dependent effect. (2006) (27)
Assessment of Cartilage Changes Over Time in Knee Osteoarthritis Disease‐Modifying Osteoarthritis Drug Trials Using Semiquantitative and Quantitative Methods: Pros and Cons (2013) (27)
Treatment with Tiludronic Acid Helps Reduce the Development of Experimental Osteoarthritis Lesions in Dogs with Anterior Cruciate Ligament Transection Followed by Reconstructive Surgery: A 1-Year Study with Quantitative Magnetic Resonance Imaging (2011) (27)
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Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis (2009) (27)
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Measurements of canine aqueous humor inflammatory mediators and the effect of carprofen following anterior chamber paracentesis. (2011) (26)
Egr-1 contributes to IL-1-mediated down-regulation of peroxisome proliferator-activated receptor γ expression in human osteoarthritic chondrocytes (2012) (26)
Nimesulide reduces interleukin-1beta-induced cyclooxygenase-2 gene expression in human synovial fibroblasts. (2001) (25)
Enhancement of phosphorylation and transcriptional activity of the glucocorticoid receptor in human synovial fibroblasts by nimesulide, a preferential cyclooxygenase 2 inhibitor. (1999) (25)
Meniscal tear and extrusion are strongly associated with the progression of knee osteoarthritis as assessed by quantitative magnetic resonance (2004) (24)
Identification in human osteoarthritic chondrocytes of proteins binding to the novel regulatory site AGRE in the human matrix metalloprotease 13 proximal promoter. (2006) (24)
Concurrent validity of different functional and neuroproteomic pain assessment methods in the rat osteoarthritis monosodium iodoacetate (MIA) model (2016) (24)
mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis (2011) (23)
Magnetic Resonance Imaging–Assessed Vastus Medialis Muscle Fat Content and Risk for Knee Osteoarthritis Progression: Relevance From a Clinical Trial (2015) (23)
Natural history and clinical significance of meniscal tears over 8 years in a midlife cohort (2016) (23)
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Tissue inhibitor of metalloproteinase-2 (TIMP-2) mRNA is constitutively expressed in bovine, human normal, and osteoarthritic articular chondrocytes. (1996) (23)
Suppression of tumor necrosis factor (TNF-alpha) gene expression by prostaglandin E(2). Role Of early growth response protein-1 (Egr-1). (1999) (23)
A medicinal herb-based natural health product improves the condition of a canine natural osteoarthritis model: a randomized placebo-controlled trial. (2014) (22)
Knee effusion volume assessed by magnetic resonance imaging and progression of knee osteoarthritis: data from the Osteoarthritis Initiative (2018) (22)
Diagnostic validity and triage concordance of a physiotherapist compared to physicians’ diagnoses for common knee disorders (2017) (22)
Increased expression of lipocalin-type prostaglandin D2 synthase in osteoarthritic cartilage (2008) (22)
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Differential regulation of the bone morphogenic protein antagonist chordin in human normal and osteoarthritic chondrocytes (2006) (22)
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Oral treatment with a Brachystemma calycinum D don plant extract reduces disease symptoms and the development of cartilage lesions in experimental dog osteoarthritis: inhibition of protease-activated receptor 2 (2009) (21)
New Emerging Role of Pitx1 Transcription Factor in Osteoarthritis Pathogenesis (2007) (21)
Modulation of IL-1β, IL-6, TNF-α and PGE2 by pharmacological agents in explants of membranes from failed total hip replacement (2002) (21)
Meniscal extrusion promotes knee osteoarthritis structural progression: protective effect of strontium ranelate treatment in a phase III clinical trial (2015) (21)
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Total Knee Replacement as a Knee Osteoarthritis Outcome (2013) (20)
Modulation of collagenase 3 in human osteoarthritic cartilage by activation of extracellular transforming growth factor beta: role of furin convertase. (2000) (20)
[(18)F]-fluorodeoxyglucose positron emission tomography of the cat brain: A feasibility study to investigate osteoarthritis-associated pain. (2015) (19)
Meniscal tear and increased tibial plateau bone area in healthy post-menopausal women. (2008) (19)
Regulation of interleukin 1 receptors in human articular chondrocytes. (1991) (19)
OARSI Clinical Trials Recommendations: Hand imaging in clinical trials in osteoarthritis. (2015) (19)
Biologics and the cardiovascular system: a double-edged sword. (2013) (19)
Deletion of 12/15-lipoxygenase accelerates the development of aging-associated and instability-induced osteoarthritis. (2017) (19)
Pharmacologic therapy of osteoarthritis (1999) (19)
Carprofen reduces the structural changes and the abnormal subchondral bone metabolism of experimental osteoarthritis. (1999) (19)
In vitro effects of NSAIDs and corticosteroids on the synthesis and secretion of interleukin 1 by human osteoarthritic synovial membranes. (1993) (18)
Usefulness of specific OA biomarkers, Coll2-1 and Coll2-1NO2, in the anterior cruciate ligament OA canine model. (2012) (18)
Expression of Peroxisome Proliferator-activated Receptors α, β, γ, and H- and L-Prostaglandin D Synthase During Osteoarthritis in the Spontaneous Hartley Guinea Pig and Experimental Dog Models (2013) (18)
The offspring of people with a total knee replacement for severe primary knee osteoarthritis have a higher risk of worsening knee pain over 8 years (2014) (18)
Role of EFNB1 and EFNB2 in Mouse Collagen‐Induced Arthritis and Human Rheumatoid Arthritis (2015) (18)
Refinement of the Montreal Instrument for Cat Arthritis Testing, for Use by Veterinarians: detection of naturally occurring osteoarthritis in laboratory cats (2017) (18)
A fully automated system for quantification of knee bone marrow lesions using MRI and the osteoarthritis initiative cohort (2012) (18)
Calphostin C induces AP1 synthesis and AP1‐dependent c‐jun transactivation in normal human chondrocytes independent of protein kinase c‐α inhibition: Possible role for c‐jun N‐terminal kinase (2000) (18)
In vitro effects of 2 antirheumatic drugs on the synthesis and expression of proinflammatory cytokines in synovial membranes from patients with rheumatoid arthritis. (1996) (18)
Mesenchymal Stromal Cell Immunology for Efficient and Safe Treatment of Osteoarthritis (2020) (18)
A novel negative regulatory element in the human collagenase-3 proximal promoter region. (2002) (17)
Effects of Aceclofenac and Diclofenac on Synovial Inflammatory Factors in Human Osteoarthritis (1997) (17)
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Osteoarthritis: A single injection of anakinra for treating knee OA? (2009) (17)
Glucosamine Sulfate Reduces Prostaglandin E2 Production in Osteoarthritic Chondrocytes Through Inhibition of Microsomal PGE Synthase-1 (2012) (16)
The therapeutic effects of NSAID and corticosteroids in osteoarthritis: to be or not to be. (1989) (16)
The Novartis-ILAR Rheumatology Prize 2001 Osteoarthritis: from molecule to man (2001) (16)
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Exploring determinants predicting response to intra-articular hyaluronic acid treatment in symptomatic knee osteoarthritis: 9-year follow-up data from the Osteoarthritis Initiative (2018) (16)
Effects of Nimesulide and Naproxen on the Degradation and Metalloprotease Synthesis of Human Osteoarthritic Cartilage (2012) (16)
Metabolic activity of osteoblasts from periprosthetic trabecular bone in failed total hip arthroplasties and osteoarthritis as markers of osteolysis and loosening. (2002) (15)
Metalloproteases and Their Modulation as Treatment in Osteoarthritis (2000) (15)
High in vivo levels of adipsin lead to increased knee tissue degradation in osteoarthritis: data from humans and animal models (2018) (15)
Characterization of opticin digestion by proteases involved in osteoarthritis development. (2014) (15)
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Transcriptional regulation of plasminogen activator inhibitor-1 expression in human synovial fibroblasts by prostaglandin E2: mediation by protein kinase A and role of interleukin-1 (1994) (14)
Degradative changes in human articular cartilage induced by chemotherapeutic agents. (1986) (14)
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Hsp90β and p130cas: novel regulatory factors of MMP-13 expression in human osteoarthritic chondrocytes (2008) (14)
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Cytokines and Growth Factors in the Treatment of Osteoarthritis: What Could be the Best Disease Modifying Drugs (2005) (5)
Activation of The Phosphatidylcholine to Lysophosphatidylcholine Pathway Is Associated with Osteoarthritis Knee Cartilage Volume Loss Over Time (2019) (5)
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A18 THE LOSS OF CARTILAGE VOLUME/THICKNESS ON THE WEIGHT BEARING AREAS IN KNEE OSTEOARTHRITIS PATIENTS, ASSESSED BY QUANTITATIVE MRI, IS CORRELATEDWITH SEVERITY OF SYMPTOMS AND WORSENING OF PAIN OVER TIME (2006) (4)
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Features assessed on magnetic resonance images improve prediction of total knee arthroplasty in subjects with symptomatic radiographic knee osteoarthritis: data from the osteoarthritis initiative (2014) (2)
Is there a mitochondrial DNA haplogroup connection between osteoarthritis and elite athletes? A narrative review (2022) (2)
185 PROSTAGLANDIN D2 INHIBITS INTERLEUKIN-1-β-INDUCED MATRIX METALLOPROTEINASE-1 AND −13 PRODUCTION BY HUMAN CHONDROCYTES VIA ITS DP1 RECEPTOR AND CAMP/PKA PATHWAY (2008) (2)
THU0220 Impact of Meniscal Extrusion on the Progression of Knee Osteoarthritis Structural Changes and the Effects of Treatment: Data from the Osteoarthritis Initiative Progression Cohort (2014) (2)
323 TREATMENT WITH CHONDROITIN SULFATE REDUCES CARTILAGE VOLUME LOSS IN KNEE OA PATIENTS ASSESSED BY MRI: A RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED PILOT STUDY (2010) (2)
SAT0438 Magnetic Resonance Imaging Markers as Predictors for Total Knee Replacement over 10.7 Years in Older Adults (2016) (2)
[Etiopathogenesis of osteoarthrosis in man: current concepts]. (1983) (2)
Vastus medialis intramuscular fat is associated with reduced quadriceps strength, but not knee osteoarthritis severity. (2022) (2)
Correction: Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease 13 - identification of a new biglycan cleavage site (2013) (2)
SAT0417 Insight into the Role of Meniscal Extrusion and Bone Marrow Lesions in Knee Osteoarthritis Progression and their Impact on Response to Strontium Ranelate Treatment in A Subset of Patients from the SEKOIA Study (2014) (2)
FRI0417 IDENTIFICATION OF THE MOST IMPORTANT FEATURES OF KNEE OSTEOARTHRITIS PROGRESSORS USING MACHINE LEARNING METHODS (2020) (2)
Oral treatment with PD-0200347, an α2δ ligand, reduces the development of experimental osteoarthritis by inhibiting the chondrocytes metalloproteases and inducible nitric oxide synthase gene expression and synthesis (2004) (2)
Egr-1 mediates the suppressive effect of IL-1 on PPARg expression in human OA chondrocytes (2012) (2)
Measurement of Interleukin mRNA by Northern Blotting Using a Nonradioactive Detection Method (2001) (2)
Prostaglandin D2 enhances interleukin -1beta- induced cyclooxygenase-2 expression in osteoarthritic cartilage (2010) (2)
OSTEOARTHRITIS and CARTILAGE The increased synthesis of inducible nitric oxide inhibits IL-lra synthesis by human articular chondrocytes: possible role in osteoarthritic cartilage degradation (1996) (2)
Combined chondroitin sulfate and Glucosamine versus celecoxib for painful Knee osteoarthritis: post-hoc analyses by Kellgren and Lawrence grade and C-reactive protein level from a randomized, double-blind, multicentre clinical trial (2015) (2)
Prediction of total knee replacement in a 6-month multicentre clinical trila with chondroitin sulfate in knee osteoarthritis: results from a 4-year observation (2012) (2)
62 PROTECTIVE EFFECTS OF AVOCADO/SOYBEAN UNSAPONIFIABLES (ASU) ON STRUCTURAL CHANGES IN EXPERIMENTAL DOG OSTEOARTHRITIS (2008) (2)
Single nucleotide polymorphism genes and mitochondrial DNA haplogroups as biomarkers for early prediction of knee osteoarthritis structural progressors: use of supervised machine learning classifiers (2022) (2)
PPARγ ligands inhibit catabolic and inflammatory responses in articular joint cells (2003) (2)
Recent Developments in the Therapy of Osteoarthritis (2002) (2)
Elevated serum biomarkers of inflammatory turnover of collagen types III and VI predict rapid cartilage loss (2019) (2)
004 TILUDRONATE IN AN EXPERIMENTAL DOG MODEL OF OSTEOARTHRITIS: BONE ANTI-RESORPTIVE ACTIVITY AND RELATED FUNCTIONAL IMPROVEMENT (2009) (2)
Modern Therapeutics in Rheumatic Diseases (2002) (2)
Associations of Joint Line Tenderness and Patellofemoral Grind With Long‐Term Knee Joint Outcomes: Data From the Osteoarthritis Initiative (2020) (2)
Corrigendum: ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis (2017) (2)
174 – Animal models of osteoarthritis (2015) (2)
What is the predictive value of MRI for the occurrence of hard clinical endpoints in knee osteoarthritis (2013) (2)
138 FUNCTIONAL OUTCOMES IN DOGS WITH NATURALLY OCCURRING OSTEOARTHRITIS: FORCE PLATFORM GAIT ANALYSIS AND LOCOMOTOR ACTIVITY RECORDING (2009) (2)
Expression of PPAR a, b, g, and H-and L-PGDS during osteoarthritis in the spontaneous Hartley guinea pig and the experimental dog models (2013) (2)
THU0473 Diacerein Reduces Antagonists of WNT Enabling this System's Activity in Human Osteoarthritic Subchondral Bone Osteoblasts (2015) (1)
THU0496 Combined Chondroitin Sulfate and Glucosamine is More Efficient than Celebrex in Reducing Serum Levels of COLL2-1, A Cartilage Degradation Biomarker, In Patients with Severe OA: Results from a Randomized, Double-Blind, Multicentric Clinical Trial (2015) (1)
Osteoarthritis and Cardiovascular Diseases: is Meta-Inflammation the Missing Link? (2015) (1)
OP0028 The Disease Modifying Effect of Strontium Ranelate in a Phase III Knee Osteoarthritis Study (SEKOIA) Using Quantitative Magnetic Resonance Imaging: Reduction in Bone Marrow Lesion Size Associated with Cartilage Protective Effect (2013) (1)
Resveratrol Regulates the Wnt/ß-catenin pathway in human osteoarthritis osteoblasts (2014) (1)
Differential gene expression and regulation of the bone morphogenic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts (2004) (1)
In a two-year double-blind randomized controlled multicenter study, chondroitin sulfate was significantly superior to celecoxib at reducing cartilage loss with similar efficacy at reducing disease symptoms in knee osteoarthritis patients (2016) (1)
Implication of microRNA-140 in osteoarthritis (2012) (1)
Reply (2018) (1)
The association between change in bone marrow lesion size and change in tibiofemoral cartilage volume and knee symptoms - results from the ZAP2 trial (2020) (1)
Nucleoside Triphosphate (NTP) Pyrophosphohydrolase in Chondrocalcinotic and Osteoarthritic Cartilages (1985) (1)
P272 OSTEOARTHRITIS RISK FACTORS: A CROSS-SECTIONAL STUDY OF ASSOCIATIONS BETWEEN MENISCAL TEAR AND KNEE STRUCTURE, RADIOGRAPHIC CHANGES AND SYMPTOMS IN AN UNDIAGNOSED OA COHORT (2006) (1)
In vivo effect of opticin deficiency in a surgically induced model of osteoarthritis (2017) (1)
The association between objectively measured physical activity and knee structural change using magnetic resonance imaging (MRI) (2012) (1)
152 Hsp90 AND p130cas: NOVEL REGULATORY FACTORS OF MMP-13 EXPRESSION IN HUMAN OSTEOARTHRITIC CHONDROCYTES (2007) (1)
282 BONE MARROW LESIONS IN PEOPLE WITH KNEE OSTEOARTHRITIS PREDICT PROGRESSION OF DISEASE AND JOINT REPLACEMENT (2009) (1)
In Vitro Effects of Tiaprofenic Acid, Sodium Salicylate and Hydrocortisone on Human Osteoarthritic Cartilage Degradation and Synovial Collagenase Synthesis (2012) (1)
Long-term effects of treatment on the progression of structural changes in knee osteoarthritis: 6-year follow-up (2016) (1)
The effects of treatment on disease symptoms and progression of structural changes in knee osteoarthritis: Participants from the osteoarthritis initiative progression cohort (2015) (1)
Welcome from the President and Program Co-Chairs (2009) (1)
Magnetic resonance imaging (MRI)-assessed knee abnormalities in Australian rules football players – AFL tas knee study (2015) (1)
Comment on: Bone marrow lesions in people with knee osteoarthritis predict progression of disease and joint replacement: a longitudinal study: reply (2011) (1)
The use of gene therapy in osteoarthritis: present and future (1999) (1)
328 MAGNETIC RESONANCE IMAGING (MRI) ALLOWS FOR PRECISE AND RELIABLE ASSESSMENT OF SYNOVIAL MEMBRANE THICKNESS IN KNEE OA PATIENTS (2007) (1)
13 THE REMODELLING PROCESS OF THE SUBCHONDRAL BONE DURING HUMAN OSTEOARTHRITIS IS CLOSELY DEPENDENT ON RANKL MODULATION (2007) (1)
Use of animal models for testing drugs targeting osteoarthritis symptoms and articular tissue structural changes (2013) (1)
High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1 b in osteoarthritic synoviocytes (2010) (1)
Faculty Opinions recommendation of Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: activation of an anti-inflammatory cyclooxygenase-2 (COX-2) pathway. (2011) (1)
Estrogenic impregnation alters pain expression: analysis through functional neuropeptidomics in a surgical rat model of osteoarthritis (2022) (1)
The longitudinal relationship between changes in body weight and changes in knee cartilage and pain among community-based adults with and without meniscal tears (2013) (1)
077 RELATIONSHIP BETWEEN CANINE STIFLE STRUCTURAL DAMAGES AND FUNCTIONAL IMPAIRMENT IN EXPERIMENTAL OSTEOARTHRITIS: PODOBAROMETRIC GAIT ANALYSIS COUPLED WITH 1.5 TESLA MAGNETIC RESONANCE IMAGING (2009) (1)
Risk factors associated with the occurrence of total knee arthroplasty in patients with knee osteoarthritis: a nested case–control study (2022) (1)
PD-0200347, an a2d ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCa dependent effect (2006) (1)
Peroxisome proliferator-activated receptor gamma 1 expression is diminished in human osteoarthritis cartilage and is downregulated by IL-1β in articular chondrocytes (2007) (1)
039 VALIDITY OF PAIN ASSESSMENT METHODS IN THE EXPERIMENTAL DOG POND-NUKI MODEL (2009) (1)
Abnormal osteogenesis in osteoarthritis: gone with the Wnt? (2012) (1)
L-PGDS deletion accelerates the development of aging-associated osteoarthritis (2021) (1)
Viewpoint on Time Series and Interrupted Time Series Optimum Modeling for Predicting Arthritic Disease Outcomes (2020) (1)
New emerging roles of transcription factor Pitx1 and Reg growth factors in osteoarthritis pathogenesis (2004) (0)
180 PGD2 DOWNREGULATES MMP-1 AND MMP-13 EXPRESSION IN HUMAN OSTEOARTHRITIC CHONDROCYTES (2007) (0)
The effect of knee alignment on cartilage loss differs based on anterior cruciate ligament status in patients with or at risk of knee osteoarthritis: data from the osteoarthritis initiative (2019) (0)
15-Deoxy-Δ12,14-prostaglandin J2 inhibits IL-1β-induced cyclooxygenase-2 expression in human synovial fibroblasts through a histone deacetylase-independent mechanism (2004) (0)
A continuous data driven translational model to evaluate effectiveness of population-level health interventions: case study, smoking ban in public places on hospital admissions for acute coronary events (2020) (0)
Egr-1 mediates the suppressive effect of IL-1 on PPARγ expression in human OA chondrocytes (2012) (0)
MRI-detected subchondral bone marrow lesions: does using two mri sequences improve detection and clinical relevance? (2018) (0)
How Do MRI-Detected Subchondral Bone Marrow Lesions (BMLs) on Two Different MRI Sequences Correlate with Clinically Important Outcomes? (2018) (0)
Combined Chondroitin Sulfate and Glucosamine Is Comparable to Celecoxib for Painful Knee Osteoarthritis. Results from a Multicenter, Randomized, Double-Blind, PHASE IV NON-Inferiority TRIAL. (2014) (0)
230 VALPROIC ACID SUPPRESSES INTERLEUKIN-1β-INDUCED MICROSOMAL PROSTAGLANDIN E2 SYNTHASE-1 EXPRESSION IN CHONDROCYTES (2010) (0)
Chondroitin sulfate regulates two anti-angiogenic factors in human osteoarthritic synovial fibroblasts (2013) (0)
113 A DECREASE IN SERUM LEVEL OF MATRIX METALLOPROTEASES IS PREDICTIVE OF A DRUG'S DMOAD EFFECT ASSESSED BY QUANTITATIVE MRI IN KNEE OSTEOARTHRITIS PATIENTS (2010) (0)
Faculty Opinions recommendation of Spinal interleukin-1beta in a mouse model of arthritis and joint pain. (2009) (0)
Activation ofneutral metalloprotease inhuman osteoarthritic kneecartilage: evidence for degradation inthecore protein ofsulphated proteoglycan (1988) (0)
In vivo effect of opticin deficiency in cartilage in a surgically induced mouse model of osteoarthritis (2018) (0)
Expression of PPARα, β, and γ in the Hartley guinea pig model of primary osteoarthritis (2012) (0)
141 INTERFERENCE OF CHANGES IN BODY WEIGHT ON THE WEIGHT BEARING OF DOGS WITH NATURALLY OCCURRING OSTEOARTHRITIS (2009) (0)
Relationships between vastus medialis fat infiltration with body mass index, disease severity and anterior cruciate ligament status in patients with knee osteoarthritis (2019) (0)
What is the value of biomarkers for drug development in osteoarthritis (2013) (0)
SAT0042 Characterization of Levels of Col3Del (MMP13 ISOFORM) Protein Production and Collagenolytic Activity in Human Osteoarthritic (OA) Samples (2015) (0)
Hepatocyte growth factor in osteoarthritis: when bone and cartilage decide to have a chat (2003) (0)
OP0096 Meniscal Extrusion and Bone Marrow Lesions Are Independently Associated with Incident and Progressive Knee Osteoarthritis (2016) (0)
F1000Prime recommendation of Effect of low-dose oral prednisolone on symptoms and systemic inflammation in older adults with moderate to severe knee osteoarthritis: a randomized placebo-controlled trial. (2014) (0)
59 CARTILAGE-SPECIFIC DELETION OF PPAR-GAMMA IN MICE RESULTS IN EARLY ENDOCHONDRAL OSSIFICATION DEFECTS AND ACCELERATED AGING-DEPENDENT DEVELOPMENT OF OSTEOARTHRITIS (2011) (0)
Validation of pain assessment methods with clinical canine osteoarthritis (2010) (0)
Knee osteoarthritis progression evaluated by magnetic resonance imaging and a novel quantification imaging system (2001) (0)
Development of Two Innovative Performance-Based Objective Measures in Feline Osteoarthritis: Their Reliability and Responsiveness to Firocoxib Analgesic Treatment (2022) (0)
OP0181 Deletion of the prostaglandin D2 receptor DP1 exacerbates aging-associated and instability-induced osteoarthritis (2017) (0)
AB0067 Chondroitin sulfate regulates two anti-angiogenic factors in human osteoarthritic synovial fibroblasts (2013) (0)
Influence of Tumor Necrosis Factor α, Parathyroid Hormone, and Vitamin D3 on Modulation of the RANKL2 Isoform (2012) (0)
Egr-1 mediates the suppressive effect of IL-1 on PPARγ expression in human OA chondrocytes (2012) (0)
051 CONTRIBUTION OF HIGH MOBILITY GROUP BOX 1 TO SYNOVITIS IN OSTEOARTHRITIS (2010) (0)
The ephrin-B2/EphB4 system is required in musculoskeletal development and protects the articulation during osteoarthritis: a research highlight (2016) (0)
SAT0560 From a 2-year multicentre clinical trial in knee osteoarthritis, a metabolomic analysis reveals that over activation of the conversion pathway of phosphatidylcholine to lysophosphatidylcholine is associated with knee cartilage volume loss over time (2018) (0)
Positive patellofemoral grind test but not joint line tenderness predicts incident and progressive knee osteoarthritis–data from the osteoarthritis initiative (2016) (0)
475 PROSTAGLANDIN D2 ENHANCES INTERLEUKIN -1BETA- INDUCED CYCLOOXYGENASE-2 EXPRESSION IN OSTEOARTHRITIC SYNOVIOCYTES (2010) (0)
Magnetic resonance imaging assessments for knee segmentation and their use in combination with machine/deep learning as predictors of early osteoarthritis diagnosis and prognosis (2023) (0)
POS0231 GENETIC BIOMARKERS, SNP GENES AND mtDNA HAPLOGROUPS, PREDICT OSTEOARTHRITIS STRUCTURAL PROGRESSORS THROUGH THE USE OF SUPERVISED MACHINE LEARNING (2022) (0)
476 STERNAL FRACTURE AFTER MINOR TRAUMA IN A PATIENT WITH KYPHOSIS: A CASE REPORT (2009) (0)
EXPRESSION AND FUNCTION OF 15-PGDH IN CARTILAGE (2022) (0)
75 QUANTITATIVE MRI ASSESSMENT OF THE PROGRESSION OF KNEE STRUCTURAL CHANGES IN AN OSTEOARTHRITIS EXPERIMENTAL DOG MODEL: CORRELATION WITH MACROSCOPIC FINDINGS (2007) (0)
OP0303 CORTICOSTEROID INJECTION IN KNEE OSTEOARTHRITIS IS ASSOCIATED WITH REDUCTION IN MENISCAL THICKNESS AND JOINT SPACE WIDTH WITH NO EFFECT ON CARTILAGE THICKNESS: A CASE CONTROL STUDY (2020) (0)
Validity of pain assessment methods in an experimental dog model (2010) (0)
Aberrant expression of autophagy markers during osteoarthritis (2013) (0)
354 PROINFLAMMATORY MEDIATORS DOWNREGULATE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ1 EXPRESSION AND ACTIVITY IN OSTEOARTHRITIC SYNOVIAL FIBROBLASTS (2007) (0)
Abnormal collagen type I production in osteoarthritic subchondral bone is associated with a reduced capacity of osteoblasts to mineralize in vitro (2004) (0)
FRI0009 Accelerated development of aging-associated and instability-induced osteoarthritis in 12/15-lipoxygenase deficient mice (2017) (0)
THU0223 Vastus Medialis Muscle FAT Content as Assessed by Magnetic Resonance Imaging is A Risk Factor for Knee Osteoarthritis Progression: Relevance in A Clinical Trial (2014) (0)
DISRUPTION OF ENDOPLASMIC RETICULUM STRESS SIGNALING IN CARTILAGE-SPECIFIC SITE-1 PROTEASE KNOCKOUT MICE RESULTS IN ABNORMAL MATRIX AND LACK OF ENDOCHONDRAL OSSIFICATION (2007) (0)
Quantitative Magnetic Resonance Imaging Transection Followed by Reconstructive Surgery : A 1-Year Study with Experimental Osteoarthritis Lesions in Dogs with Anterior Cruciate Ligament Treatment with Tiludronic Acid Helps Reduce the Development of LUSSIER and (2010) (0)
Serum adipokines/related inflammatory factors and ratios as predictors of infrapatellar fat pad volume in osteoarthritis: Applying comprehensive machine learning approaches (2020) (0)
Faculty Opinions recommendation of Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial. (2013) (0)
P67 THE IN VIVO ACTIVATION OF PPARã BY THE LIGAND PIOGLITAZONE REDUCES THE DEVELOPMENT OF CARTILAGE LESIONS AND SYNTHESIS OF CATABOLIC FACTORS IN AN OSTEOARTHRITIS DOG MODEL (2006) (0)
Inducible cartilage-specific PPARgamma-deficient mice exhibit accelerated experimentally-induced osteoarthritis associated with defective autophagy and mTOR signaling (2013) (0)
The relationship between measures of knee loading during gait and cartilage thickness in non-traumatic and post-traumatic knee osteoarthritis (2017) (0)
A clinically detected knee effusion is associated with current and future knee symptoms–data from the osteoarthritis initiative (2016) (0)
Association between metformin use and disease progression in obese people with knee osteoarthritis – data from the osteoarthritis initiative (2018) (0)
Baseline and persistent knee symptoms are independent predictors of structural progression of knee osteoarthritis (2016) (0)
Faculty Opinions recommendation of Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis. (2014) (0)
A 2-year evaluation of disease progression by quantitative magnetic resonance imaging in a large primary osteoarthritic patient population (2004) (0)
85 FOLLOW-UP OF COLL2-1 COLL2-1NO2 AND MYELOPEROXYDASE IN DOGS AFTER TRANSECTION OF THE CRUCIATE LIGAMENT OF THE KNEE (2008) (0)
330 MAGNETIC RESONANCE IMAGING: AN OPEN-LABEL PILOT STUDY EVALUATING THE DISEASE MODIFYING EFFECT OF CELECOXIB COMPARED TO A MODELIZED HISTORICAL CONTROL COHORT IN KNEE OSTEOARTHRITIS (2009) (0)
317 NEW QUANTITATIVE MRI TECHNOLOGY CAN RELIABLY ASSESS HUMAN HIP CARTILAGE VOLUME AND THICKNESS AND DISCRIMINATE THE ACETABULUM FROM THE FEMORAL HEAD (2007) (0)
SAT0560 The in Vivo Role of Bone Specific Ephb4 Receptor Overexpression in Osteoarthritic Synovial Membrane (2014) (0)
237 POSITIVE REGULATION OF HUMAN OSTEOARTHRITIC CHONDROCYTES UPON ACTIVATION OF THE EphB4 RECEPTOR BY ITS SPECIFIC LIGAND EPHRIN B2 (2009) (0)
Clinical relevance of MRI knee abnormalities in Australian rules football players: a longitudinal study (2021) (0)
Knee function, pain and magnetic resonance imaging abnormalities in Australian Rules Football players: a cohort study (2017) (0)
The long-term effects of SYSADOA treatment on knee osteoarthritis symptoms and progression of structural changes: participants from the Osteoarthritis Initiative progression cohort (2013) (0)
Faculty Opinions recommendation of Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model. (2013) (0)
Response to: ‘Does it make sense to investigate whether the offspring of people with a total knee replacement for severe primary knee osteoarthritis have a higher risk of worsening knee pain?’ by Lei et al (2015) (0)
Faculty Opinions recommendation of Evidence that TNF-β (lymphotoxin α) can activate the inflammatory environment in human chondrocytes. (2014) (0)
Martel-Pelletier tomorrow with new imaging technology Therapeutic targets in osteoarthritis : from today to (2003) (0)
Faculty Opinions recommendation of Efficacy and tolerability of celecoxib in the treatment of acute gouty arthritis: a randomized controlled trial. (2012) (0)
18 BODY COMPOSITION AND MENISCAL TEARS IN COMMUNITY BASED ADULTS (2011) (0)
P259 CORRELATION OF BONE LESION CHANGES WITH CARTILAGE VOLUME LOSS IN KNEE OSTEOARTHRITIS PATIENTS AS ASSESSED BY QUANTITATIVE MRI OVER A TWO-YEAR PERIOD (2006) (0)
Osteoarthritis in 2010 (2010) (0)
105 IN VIVO EFFECT OF BONE-SPECIFIC EPHB4 OVEREXPRESSION IN MICE ON SUBCHONDRAL BONE AND CARTILAGE DURING OSTEOARTHRITIS (2011) (0)
SAT0455 Baseline and Persistent Knee Symptoms Are Independent Predictors of Structural Progression of Knee Osteoarthritis (2016) (0)
17 Recent Developments in the Therapy of Osteoarthritis (0)
008 BONE MARROWLESIONS, CARTILAGE LOSS, AND PAIN IN KNEE OSTEOARTHRITIS: RESULTS FROM A RANDOMIZED CONTROLLED CLINICAL TRIAL USING MRI (2010) (0)
Diagnostic and surgical triage concordance between a physiotherapist and physicians for patients suffering from knee osteoarthritis (2016) (0)
AB0994 Exploring knee osteoarthritis pain trajectories and movement-evoked pain changes during a 24-week outdoor walking program (WALK) (2022) (0)
Faculty Opinions recommendation of Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells. (2012) (0)
459 JOINT MACROSCOPIC DAMAGES AND FUNCTIONAL IMPAIRMENT IN EXPERIMENTAL CANINE OSTEOARTHRITIS (2009) (0)
071 ORAL TREATMENT WITH THE PLANT EXTRACT OF BRACHYSTEMMA CALYCINUM D. DON REDUCES THE DEVELOPMENT OF CARTILAGE LESIONS IN EXPERIMENTAL DOG OSTEOARTHRITIS: INHIBITION OF PROTEASE ACTIVATED RECEPTOR-2 (2009) (0)
Faculty Opinions recommendation of Magnetic resonance imaging-based three-dimensional bone shape of the knee predicts onset of knee osteoarthritis: data from the osteoarthritis initiative. (2013) (0)
technique to assess osteoarthritis-associated disability Coxofemoral joint kinematics using video fluoroscopic images of treadmill-walking cats: development of a (2014) (0)
VI ARTHRITIS Gene Therapy for Osteoarthritis New Perspectives for the Twenty-First Century (2000) (0)
The bulge sign (cid:2) a simple physical examination for identifying progressive knee osteoarthritis: data from the Osteoarthritis Initiative RHEUMATOLOGY (2020) (0)
SAT0534 MAGNETIC RESONANCE IMAGING MARKERS IMPROVE THE PREDICTION MODEL FOR TOTAL KNEE REPLACEMENT OVER 13 YEARS IN OLDER ADULTS (2019) (0)
378 HISTONE DEACETYLASE INHIBITORS PREVENT INTERLEUKIN-1-INDUCED MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 EXPRESSION IN HUMAN CHONDROCYTES: ROLE OF EGR-1 (2009) (0)
New strategies for the in vivo regulation of metalloprotease gene expression in osteoarthritis chondrocytes by inflammatory mediators (2003) (0)
Expression of PPARα, β, and γ in the Hartley guinea pig model of primary osteoarthritis (2012) (0)
New Therapeutic Targets for Osteoarthritis: The Rewards of Research (2001) (0)
A pilot randomized controlled trial evaluating outdoor community walking for knee osteoarthritis: walk (2023) (0)
266 GLUCOSAMINE SULFATE REDUCES THE PROSTAGLANDIN E2 PRODUCTION IN OSTEOARTHRITIC CARTILAGE THROUGH THE INHIBITION OF mPGES-1 (2011) (0)
The relationship between muscle activation during gait and cartilage volume loss in patients with non-traumatic and post-traumatic knee osteoarthritis (2019) (0)
Posters: Osteoarthritis (2014) (0)
Altered phosphorylation of Syp may be responsible for abnormal insulin-like growth factor-1 signaling in human osteoarthritic osteoblasts (2003) (0)
Corrigendum to “OARSI Clinical Trials Recommendations: Knee imaging in clinical trials in osteoarthritis” [Osteoarthritis Cartilage (2015) 698–715] (2015) (0)
THU0443 The Levels of the Adipokines Leptin, Adipsin and Adiponectin Predict Knee Osteoarthritis Progression as Assessed by MRI and Total Knee Replacement Occurrence in Symptomatic Patients (2015) (0)
Valproic acid suppresses interleukin-1β-induced microsomal prostaglandin E2 Synthase-1 expression in chondrocytes (2010) (0)
386 MAGNETIC RESONANCE IMAGING: CARTILAGE DEFECT ASSESSMENT IS LESS SENSITIVE THAN THE QUANTIFICATION OF CARTILAGE VOLUME LOSS IN A KNEE OSTEOARTHRITIS DMOAD TRIAL (2011) (0)
238 MODULATION OF OSTEOPROTEGERIN, RANK, RANKL BY HUMAN CHONDROCYTES AND THEIR IMPLICATION IN OSTEOARTHRITIS (2009) (0)
THU0464 Lsd1-Mediated Demethylation of Histone H3 Lysine 9 Contributes to Interleukin 1-Induced Microsomal Prostaglandin E Synthase-1 Expression (2014) (0)
Carboxylated and uncarboxylated osteocalcin levels are not linked with insulin resistance in osteoarthritis patients (2017) (0)
A clinically detected knee effusion predicts incident and progressive knee osteoarthritis–data from the osteoarthritis initiative (2016) (0)
AB0081 Effect of chondroitin sulfate on the factors involved in synovial inflammation (2013) (0)
THU0502 The Longitudinal Relationship Between Changes in Body Weight and Changes in Knee Cartilage and Pain Among Community-Based Adults with and without Meniscal Tears (2013) (0)
FRI0416 COMBINATION OF SERUM ADIPOKINES/RELATED INFLAMMATORY FACTORS AND RATIOS AS PREDICTORS OF INFRAPATELLAR FAT PAD VOLUME IN KNEE OSTEOARTHRITIS PATIENTS: USAGE OF A COMPREHENSIVE MACHINE LEARNING APPROACH (2020) (0)
P68 AUTOLOGOUS OSTEOCHONDRAL GRAFTS IN THE TREATMENT OF FOCAL CHONDRAL DEFECTS OF THE FEMORAL HEAD. AN EXPERIMENTAL STUDY IN RABBITS (2006) (0)
Faculty Opinions recommendation of High levels of anti-cyclic citrullinated peptide autoantibodies are associated with co-occurrence of pulmonary diseases with rheumatoid arthritis. (2011) (0)
Chondroitin Sulfate Pharmacological Activity from Four Different Sources in Human Osteoarthritic Cartilage (2019) (0)
264 EFFECT OF THREE DIFFERENT CHONDROITIN SULFATES IN HUMAN OSTEOARTHRITIS CARTILAGE (2009) (0)
14 PROTEINASE-ACTIVATED RECEPTOR (PAR)-2 IN OSTEOARTHRITIC SUBCHONDRAL BONE OSTEOBLASTS: IDENTIFICATION OF A NEW THERAPEUTIC TARGET (2007) (0)
[Proceedings: Demonstration of a regulatory factor (chalone) of the renal mass]. (1975) (0)
Brief report Temporal assessment of bone marrow lesions on magnetic resonance imaging in a canine model of knee osteoarthritis: impact of sequence (2008) (0)
Evaluation d'articulations non invasive (2005) (0)
42 NFAT3 SPECIFICALLY REGULATES MIR-140 TRANSCRIPTION IN HUMAN OSTEOARTHRITIC CHONDROCYTES (2011) (0)
Faculty Opinions recommendation of Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function. (2010) (0)
203 PPARγ1 EXPRESSION IS DIMINISHED IN HUMAN OA CARTILAGE AND IS DOWN-REGULATED BY IL-1β IN ARTICULAR CHONDROCYTES (2007) (0)
Effect of chondroitin sulfate on the factors involved in synovial inflammation (2012) (0)
A continuous data driven translational model to evaluate effectiveness of population-level health interventions: case study, smoking ban in public places on hospital admissions for acute coronary events (2020) (0)
OP0209 Soluble Ephrin-B2 Ectodomain Contributes to the Pathogenesis of Systemic Sclerosis (2015) (0)
Faculty Opinions recommendation of Gene expression analysis of murine and human osteoarthritis synovium reveals elevation of transforming growth factor β-responsive genes in osteoarthritis-related fibrosis. (2014) (0)
Can we identify patients to be treated in osteoarthritis (2015) (0)
199 INTERLEUKIN-1-INDUCED COX-2 AND INOS EXPRESSION IN OA HUMAN CHONDROCYTES IS ASSOCIATED WITH HISTONE H3K4 METHYLATION (2010) (0)
PD-0200347, AN α 2 δ LIGAND OF VOLTAGE-DEPENDENT CALCIUM CHANNEL, INHIBITS IN VIVO THE ACTIVATION OF THE ERK1/2 PATHWAY IN OSTEOARTHRITIC CHONDROCYTES: A PKC α -DEPENDENT EFFECT (2005) (0)
Response to: ‘Concerns about report suggesting glucosamine and chondroitin protect against cartilage loss’ by Felson (2015) (0)
The Journal of Rheumatology osteoarthritic cartilage and chondrocytes. Expression and regulation of microsomal prostaglandin E synthase-1 in human (2005) (0)
408 DEVELOPMENT OF A FULLY AUTOMATED SYSTEM FOR THE QUANTIFICATION OF HUMAN KNEE OSTEOARTHRITIC SYNOVIAL FLUID USING MAGNETIC RESONANCE IMAGES (2009) (0)
FRI0313 Prediction of total knee replacement in a 6-month multicentre clinical trial with chondroitin sulfate in knee osteoarthritis: Results from a 4-year observation (2013) (0)
AB0876 THE BENEFIT AND SAFETY OF DIACEREIN IN AGED AND OBESE PATIENTS WITH SYMPTOMATIC KNEE OSTEOARTHRITIS: DATA FROM THE DISSCO CLINICAL STUDY (2020) (0)
088 A STATISTICAL MODELING APPROACH OF THE RELATIONSHIPS BETWEEN SPECIFIC TISSUE LESIONS AND FUNCTIONAL DISABILITY IN EXPERIMENTAL CANINE OSTEOARTHRITIS (2009) (0)
A41 EPHB4 RECEPTOR ACTIVATION BY ITS SPECIFIC LIGAND EPHRIN B2 INDUCED A REDUCED REMODELING PROCESS IN HUMAN SUBCHONDRAL BONE OSTEOBLASTS (2008) (0)
190 CARTILAGE-SPECIFIC DELETION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA IN MICE IS ASSOCIATED WITH GROWTH PLATE DEFECTS (2010) (0)
Cartilage-specific deletion of prar-gamma in mice results in early endochondral ossification defects and accelerated aging-dependent development of osteoarthritis (2012) (0)
I-16 DESIGNING AN OA CLINICAL TRIAL (2009) (0)
THU0446 DIACEREIN PROVEN AS EFFECTIVE AS CELECOXIB IN REDUCING PAIN AND SYMPTOMS IN KNEE OSTEOARTHRITIS PATIENTS IN A MULTICENTRE DOUBLE-BLIND RANDOMISED STUDY (DISSCO) (2019) (0)
SAT0561 In Vivo Cartilage-Specific Deletion of Ephrin-B2 in Mice Results in Bone Development Leading to Osteoarthritis Features (2014) (0)
Abstracts: Scientific papers, education sessions to be presented at the May 26–28, 2016 Victoria, BC (2016) (0)
529 COULD SPECIFIC PEPTIDE ANTAGONISTS OF ENDOTHELIN RECEPTOR TYPE A AND BRADYKININ RECEPTOR 1 ACT AS POTENTIAL TREATMENTS FOR OSTEOARTHRITIS (2009) (0)
An Open Debate on the Morphological Measurement Methodologies of the Infrapatellar Fat Pad to Determine Its Association with the Osteoarthritis Process (2022) (0)
Prostaglandin D2 inhibits interleukin-1β-induced matrix metalloproteinase-1 and -13 production by human osteoarthritic chondrocytes (2011) (0)
Interaction Between Alignment and Anterior Cruciate Ligament Injury On Knee Osteoarthritis Progression: Data From The Osteoarthritis Initiative (2017) (0)
152 INFLUENCE OF SOME OSTEOTROPIC FACTORS ON MODULATION OF THE RANKL2 ISOFORM (2010) (0)
Reply Letter to the Editor: Knee joint replacement and individual susceptibility for progression of knee osteoarthritis and tibial cartilage volume loss: not only genes run in the family. (2015) (0)
World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2015): ESCEO Symposia Abstracts (2015) (0)
New Therapeutic Targets for Osteoarthritis (2002) (0)
56 THE BMP ANTAGONISTS FOLLISTATIN AND GREMLIN IN NORMAL AND EARLY OSTEOARTHRITIS: AN IMMUNOHISTOCHEMICAL STUDY (2008) (0)
Corrigendum to “Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: Influence of osteotropic factors” [Bone 43 (2008) 284–291] (2009) (0)
A new decision tree for diagnosis and management of osteoarthritis in primary care: international consensus of experts. (2018) (0)
Neutral metalloproteases andagerelated changes in humanarticular cartilage (1987) (0)
258 EFFECT OF MECHANICAL STRESS OR ITS COMBINATION WITH MAPK INHIBITOR ON THE CHONDROCYTIC PHENOTYPE OF 3-DIMENSIONAL SCAFFOLD-EMBEDDED RAT CHONDROCYTES (2011) (0)
Faculty Opinions recommendation of Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees. (2008) (0)
Interleukin-1-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in human OA chondrocytes is associated with histone H3K4 methylation (2010) (0)
043 IN VIVO EVIDENCE OF THE IMPLICATION OF PROTEINASE-ACTIVATED RECEPTOR (PAR)-2 IN CARTILAGE DEGRADATION IN A MOUSE MODEL OF OSTEOARTHRITIS (2009) (0)
Verification of three different MMP-13 isoforms expression in human osteoarthritic cartilage (2013) (0)
Associations of blood pressure and arterial stiffness with knee cartilage volume in patients with knee osteoarthritis. (2021) (0)
248 HUMAN ARTICULAR CHONDROCYTES EXPRESS 15-LIPOXYGENASE-1 AND -2: POTENTIAL ROLE IN OSTEOARTHRITIS (2009) (0)
Regulation of collagenase-3 (MMP-13) gene and protein expression in human cartilage: when simple things get complicated (2003) (0)
The relationship between knee loading during gait and cartilage thickness in nontraumatic and posttraumatic knee osteoarthritis (2021) (0)
183 HISTONE DEACETYLASE INHIBITORS SUPPRESS INTERLEUKIN-1β-INDUCED MPGES-1 EXPRESSION IN HUMAN CHONDROCYTES (2008) (0)
Differential regulation of autophagy in articular cartilage chondrocytes and synovial fibroblasts during osteoarthritis (2015) (0)

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