John Abelson
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Molecular biologist
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John Abelsonbiology Degrees
Biology
#3121
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#4816
Historical Rank
#1308
USA Rank
Molecular Biology
#870
World Rank
#893
Historical Rank
#187
USA Rank
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Biology
John Abelson's Degrees
- Bachelors Biology University of California, Berkeley
- PhD Molecular Biology Stanford University
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Why Is John Abelson Influential?
(Suggest an Edit or Addition)According to Wikipedia, John Norman Abelson is an American molecular biologist with expertise in biophysics, biochemistry, and genetics. He was a professor at the California Institute of Technology . Biography Abelson graduated in 1960 with a bachelor's degree in physics from Washington State University. He obtained his Ph.D. in biophysics from Johns Hopkins University in 1965. He then did a postdoctoral fellowship in biochemistry at the MRC Laboratory of Molecular Biology, Molecular Genetics Division, Cambridge, England, where he worked with Sydney Brenner and Francis Crick on the mechanism of nonsense suppressors in E.coli. This work involved both genetics and RNA sequencing .
John Abelson's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Amber Suppression: a Nucleotide Change in the Anticodon of a Tyrosine Transfer RNA (1968) (357)
- The anatomy of the T5 bacteriophage DNA molecule (1966) (339)
- Spliceosome assembly in yeast. (1987) (321)
- The "spliceosome": yeast pre-messenger RNA associates with a 40S complex in a splicing-dependent reaction. (1985) (315)
- Isolation and characterization of pre-mRNA splicing mutants of Saccharomyces cerevisiae. (1989) (309)
- Requirement of the RNA helicase-like protein PRP22 for release of messenger RNA from spliceosomes (1991) (306)
- Composition and functional characterization of the yeast spliceosomal penta-snRNP. (2002) (302)
- Yeast mRNA splicing in vitro. (1985) (259)
- Lariat structures are in vivo intermediates in yeast pre-mRNA splicing (1984) (259)
- Prp43: An RNA helicase-like factor involved in spliceosome disassembly. (1997) (234)
- Pre-mRNA splicing in yeast. (1991) (226)
- An early hierarchic role of U1 small nuclear ribonucleoprotein in spliceosome assembly. (1988) (218)
- Nicotinic receptor binding site probed with unnatural amino acid incorporation in intact cells. (1995) (208)
- The Yeast tRNA Splicing Endonuclease: A Tetrameric Enzyme with Two Active Site Subunits Homologous to the Archaeal tRNA Endonucleases (1997) (202)
- Changing the identity of a transfer RNA (1986) (197)
- Duplicate genes for tyrosine transfer RNA in Escherichia coli. (1970) (188)
- Mutations in conserved intron sequences affect multiple steps in the yeast splicing pathway, particularly assembly of the spliceosome. (1986) (185)
- Directed mutagenesis of dihydrofolate reductase. (1983) (179)
- Two domains of yeast U6 small nuclear RNA required for both steps of nuclear precursor messenger RNA splicing (1990) (165)
- Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. (1999) (161)
- The DEAH‐box protein PRP22 is an ATPase that mediates ATP‐dependent mRNA release from the spliceosome and unwinds RNA duplexes (1998) (160)
- tRNA Splicing* (1998) (159)
- The transfer RNA identity problem: a search for rules. (1994) (149)
- Crystal structure of a DEAD box protein from the hyperthermophile Methanococcus jannaschii. (2001) (146)
- Saccharomyces cerevisiae tRNA ligase. Purification of the protein and isolation of the structural gene. (1986) (143)
- Crystal structure and evolution of a transfer RNA splicing enzyme. (1998) (139)
- Evidence for a base-pairing interaction between U6 small nuclear RNA and 5' splice site during the splicing reaction in yeast. (1992) (139)
- Molecular consequences of specific intron mutations on yeast mRNA splicing in vivo and in vitro (1985) (137)
- Biochemical and genetic analyses of the U5, U6, and U4/U6 x U5 small nuclear ribonucleoproteins from Saccharomyces cerevisiae. (2001) (128)
- In vitro assembly of yeast U6 snRNP: a functional assay. (1989) (122)
- Substrate recognition and splice site determination in yeast tRNA splicing (1988) (120)
- The Saccharomyces cerevisiae Prp5 Protein Has RNA-dependent ATPase Activity with Specificity for U2 Small Nuclear RNA* (1996) (119)
- PRP4: a protein of the yeast U4/U6 small nuclear ribonucleoprotein particle (1989) (115)
- The subnuclear localization of tRNA ligase in yeast (1987) (114)
- Isolation of a temperature-sensitive mutant with an altered tRNA nucleotidyltransferase and cloning of the gene encoding tRNA nucleotidyltransferase in the yeast Saccharomyces cerevisiae. (1990) (111)
- The yeast RNA gene products are essential for mRNA splicing in vitro (1986) (108)
- Mutational analysis of the yeast U2 snRNA suggests a structural similarity to the catalytic core of group I introns (1992) (102)
- Conformational dynamics of single pre-mRNA molecules during in vitro splicing (2010) (102)
- The nucleotide sequences of tyrosine transfer RNAs of Escherichia coli. (1970) (100)
- Mutant tyrosine transfer ribonucleic acids. (1970) (99)
- PRP5: a helicase-like protein required for mRNA splicing in yeast. (1990) (99)
- Splicing of yeast nuclear pre-mRNA in vitro requires a functional 40S spliceosome and several extrinsic factors. (1987) (97)
- Mutations in the lactose operon caused by bacteriophage Mu. (1972) (96)
- An Engineered Tetrahymena tRNAGln for in Vivo Incorporation of Unnatural Amino Acids into Proteins by Nonsense Suppression* (1996) (91)
- Evolution of a transfer RNA gene through a point mutation in the anticodon. (1998) (86)
- ATP requirement for Prp5p function is determined by Cus2p and the structure of U2 small nuclear RNA (2003) (86)
- In vitro reconstitution of functional yeast U2 snRNPs. (1989) (85)
- 18S rRNA processing requires the RNA helicase-like protein Rrp3. (1996) (84)
- Specific hybridization of tyrosine transfer ribonucleic acids with DNA from a transducing bacteriophage phi-80 carrying the amber suppressor gene su 3. (1967) (83)
- Domains of yeast U4 spliceosomal RNA required for PRP4 protein binding, snRNP-snRNP interactions, and pre-mRNA splicing in vivo. (1990) (82)
- Heteroduplex structures of bacteriophage Mu DNA. (1973) (81)
- Thiophosphates in yeast U6 snRNA specifically affect pre-mRNA splicing in vitro. (1992) (80)
- Bacteriophage T4 transfer RNA. 3. Clustering of the genes for the T4 transfer RNA's. (1972) (79)
- Stages in the second reaction of pre-mRNA splicing: the final step is ATP independent. (1993) (74)
- Specificity of Prp24 binding to RNA: a role for Prp24 in the dynamic interaction of U4 and U6 snRNAs. (1995) (73)
- Biased Brownian ratcheting leads to pre-mRNA remodeling and capture prior to first-step splicing (2013) (73)
- SSB-1 of the yeast Saccharomyces cerevisiae is a nucleolar-specific, silver-binding protein that is associated with the snR10 and snR11 small nuclear RNAs (1990) (72)
- Yeast tRNA ligase mutants are nonviable and accumulate tRNA splicing intermediates. (1992) (72)
- An essential 45 kDa yeast transmembrane protein reacts with anti-nuclear pore antibodies: purification of the protein, immunolocalization and cloning of the gene. (1991) (70)
- PRP19: a novel spliceosomal component (1993) (69)
- A U5 small nuclear ribonucleoprotein particle protein involved only in the second step of pre-mRNA splicing in Saccharomyces cerevisiae (1993) (69)
- Site-specific crosslinks of yeast U6 snRNA to the pre-mRNA near the 5' splice site. (1996) (65)
- Mutant tyrosine tRNA of altered amino acid specificity (1972) (64)
- Summary of the genetic mapping of prophage Mu. (1973) (63)
- tRNA gene transcription in yeast: Effects of specified base substitutions in the intragenic promoter (1983) (62)
- Cell-Free Circularization of Viroid Progeny RNA by an RNA Ligase from Wheat Germ (1982) (61)
- PRP18, a protein required for the second reaction in pre-mRNA splicing (1990) (60)
- The 2′-5′ RNA Ligase of Escherichia coli (1996) (60)
- Yeast tRNA-splicing endonuclease is a heterotrimeric enzyme. (1990) (60)
- Cloning of the Vibrio harveyi luciferase genes: use of a synthetic oligonucleotide probe. (1983) (56)
- Bacteriophage Mu integration: on the mechanism of Mu-induced mutations. (1971) (56)
- Domain structure in yeast tRNA ligase. (1990) (55)
- Bacteriophage T4 transfer RNA. II. Mutants of T4 defective in the formation of functional suppressor transfer RNA. (1972) (54)
- Probing the Role of an Active Site Aspartic Acid in Dihydrofolate Reductase (1997) (53)
- Enzymatic mechanism of an RNA ligase from wheat germ. (1983) (52)
- Fractionation and characterization of a yeast mRNA splicing extract. (1986) (50)
- DNA sequence of a T4 transfer RNA gene cluster. (1980) (50)
- Crystal structure of a dimeric archaeal splicing endonuclease. (2000) (49)
- Recognition of tRNA(Cys) by Escherichia coli cysteinyl-tRNA synthetase. (1993) (49)
- A synthetic substrate for tRNA splicing. (1987) (48)
- tRNA leucine identity and recognition sets. (2000) (48)
- RNA ligase in bacteria: Formation of a 2′,5′ linkage by an E. coli extract (1983) (47)
- Binding interactions between yeast tRNA ligase and a precursor transfer ribonucleic acid containing two photoreactive uridine analogues. (1988) (47)
- In Vitro Studies of the Prp9·Prp11·Prp21 Complex Indicate a Pathway for U2 Small Nuclear Ribonucleoprotein Activation* (1996) (44)
- Yeast pre-mRNA splicing: methods, mechanisms, and machinery. (2002) (43)
- Deletion analysis of a multifunctional yeast tRNA ligase polypeptide. Identification of essential and dispensable functional domains. (1991) (42)
- In vitro construction of bacteriophage lambda and plasmid DNA molecules containing DNA fragments from bacteriophage T4. (1976) (42)
- Characterization of the inhomogeneous DNA in virions of bacteriophage Mu by DNA reannealing kinetics (1975) (41)
- A yeast mutant, PRP20, altered in mRNA metabolism and maintenance of the nuclear structure, is defective in a gene homologous to the human gene RCC1 which is involved in the control of chromosome condensation (1990) (40)
- Studies on amber suppressor tRNA. (1966) (40)
- Sequence of a RNA templated by the 3'-OH RNA terminus of defective interfering particles of vesicular stomatitis virus. (1978) (39)
- Characterization of U4 and U6 interactions with the 5' splice site using a S. cerevisiae in vitro trans-splicing system. (2001) (38)
- Preparation and fractionation of yeast splicing extract. (1990) (37)
- The Saccharomyces cerevisiae PRP21 gene product is an integral component of the prespliceosome. (1993) (37)
- Genetic mapping of the inversion loop in bacteriophage Mu DNA. (1973) (37)
- Splicing of tRNA Precursors (1995) (37)
- Novel activity of a yeast ligase deletion polypeptide. Evidence for GTP-dependent tRNA splicing. (1993) (36)
- Nucleotide sequence determination of bacteriophage T4 leucine transfer ribonucleic acid. (1973) (36)
- Single Molecule Cluster Analysis dissects splicing pathway conformational dynamics (2015) (36)
- An RNA ligase from wheat germ which participates in transfer RNA splicing in vitro. (1983) (35)
- The 5' and 3' domains of yeast U6 snRNA: Lsm proteins facilitate binding of Prp24 protein to the U6 telestem region. (2002) (35)
- Structure and function of the yeast tRNA ligase gene. (1988) (29)
- Transfer RNA synthesis in vitro. (1973) (26)
- Bacteriophage Mu integration: on the orientation of the prophage. (1973) (26)
- The conserved central domain of yeast U6 snRNA: importance of U2-U6 helix Ia in spliceosome assembly. (2002) (23)
- Multiple nucleotide cofactor use by yeast ligase in tRNA splicing. Evidence for independent ATP- and GTP-binding sites. (1993) (22)
- New tertiary constraints between the RNA components of active yeast spliceosomes: a photo-crosslinking study. (2004) (22)
- Mutational analysis of the coordinate expression of the yeast tRNAArg-tRNAAsp gene tandem (1986) (21)
- The cloning of a T4 transfer RNA gene cluster. (1980) (21)
- The 5 9 and 3 9 domains of yeast U 6 snRNA : Lsm proteins facilitate binding of Prp 24 protein to the U 6 telestem region (2002) (21)
- Electron microscopic identification of the yeast spliceosome. (1988) (21)
- Mu-1 bacteriophage DNA. (1970) (21)
- A restriction map of the T4 transfer RNA gene cluster. (1980) (20)
- Preparation of fluorescent pre-mRNA substrates for an smFRET study of pre-mRNA splicing in yeast. (2010) (19)
- Lac messenger RNA in lac Z gene mutants of Escherichia coli caused by insertion of bacteriophage Mu. (1973) (19)
- Affinity chromatography with biotinylated RNAs. (1990) (18)
- The generation and analysis of clones containing bacteriophage T4 DNA fragments. (1980) (18)
- Bacteriophage T4 tRNA Leu . (1972) (18)
- Cloning of Beneckea genes in Escherichia coli (1978) (18)
- Nucleotide sequence determination of bacteriophage T4 species I ribonucleic acid. (1975) (17)
- Mutant tyrosine transfer ribonucleic acids (1969) (16)
- Sequence of T4, T2 and T6 bacteriophage species I RNA and specific cleavage by an E. coli endonuclease. (1973) (14)
- Nucleotide sequence of an arginine transfer ribonucleic acid from bacteriophage T4. (1977) (13)
- In vitro trans-splicing in Saccharomyces cerevisiae. (1995) (13)
- Cleavage of T4 species I ribonucleic acid by Escherichia coli ribonuclease III. (1976) (13)
- RNA splicing: rearrangement of RNA sequences in the expression of split genes (1984) (12)
- Yeast tRNA-splicing endonuclease cleaves precursor tRNA in a random pathway. (1993) (12)
- The nucleotide sequence of threonine transfer RNA coded by bacteriophage T4. (1978) (11)
- Nucleotide sequence determination of bacteriophage T2 and T6 species I ribonucleic acids. (1975) (11)
- Orientation of transcription for the amber suppressor gene su 3 as determined by hybridization between tyrosine tRNA and the separated DNA strands of transducing coliphage phi80d su3. (1969) (9)
- T4 bacteriophage tRNAGly. (1973) (9)
- Construction of two Escherichia coli amber suppressor genes : tRNACUA and tRNACUA ( gene synthesis / amino acid substitution / nonsense suppression (7)
- Bacteriophage T4 tRNAs: structure, genetics, and biosynthesis. (1975) (7)
- Nucleotide sequence determination of bacteriophage T4 glycine transfer ribonucleic acid. (1974) (7)
- PRP 5 : A helicase-like protein required for mRNA splicing in yeast ( RNA helicase / yeast PRP genes / pre-mRNA splicing ) (6)
- Site‐specific deoxynucleotide substitutions in yeast U6 snRNA block splicing of pre‐mRNA in vitro (1997) (6)
- Recognition of tRNACys by Escherichia coli cysteinyl-tRNA synthetase. [Erratum to document cited in CA119(7):66333t] (1993) (5)
- Transcription in vitro of an isolated fragment of bacteriophage T4 genome. (1982) (5)
- Novel substrate specificity engineered in the arabinose binding protein. (1994) (5)
- From ab initio quantum mechanics to molecular neurobiology: A cation-p binding site in the nicotinic receptor (nicotinic acetylcholine receptorycation-p interactionyunnatural amino acids) (1998) (4)
- In vitro synthesis of end-mature, intron-containing transfer RNAs. (1989) (4)
- 8 – Messenger RNA Splicing in Yeast (1987) (4)
- Purification of yeast transfer RNA ligase. (1990) (4)
- Synthesis of tRNA in cell-free extracts. (1973) (4)
- Point mutations in yeast U6 snRNA can specifically block the first or second step of pre-mRNA splicing in vitro (2004) (3)
- Nucleotide sequence of ORF2: an open reading frame upstream of the tRNA ligase gene. (1987) (2)
- Highly purified transfer RNA splicing endonuclease from Saccharomyces cerevisiae. (1990) (2)
- spliceosome and several extrinsic factors (1987) (2)
- Site‐specific deoxynucleotide substitutions in yeast U6 snRNA block splicing of pre‐mRNA in vitro (1997) (1)
- Single Molecule Cluster Analysis Identifies Signature Dynamic Conformations along the Splicing Pathway (2016) (1)
- Yeast pre-mRNA Splicing Mutants (1989) (0)
- Genetic MappingoftheInversion LoopinBacteriophage Mu DNA (1973) (0)
- The Saccharomyces cerevisiae PRP 21 Gene Product is an Integral Component of the JE Arenas (2005) (0)
- PRP18, a Protein Required fortheSecondReaction inPre-mRNASplicing (1990) (0)
- THE VARIABLE POCKET: A POTENTIAL SITE IN tRNA FOR AAS RECOGNITION 1045 (1989) (0)
- AAAS—Newcomb Cleveland Prize (1990) (0)
- Corrections (1989) (0)
- The Saccharomyces cerevisiae PRP 21 gene product is an integral component of the prespliceosome ( splicing / spliceosome / U 2 small nuclear ribonucleoprotein ) (2005) (0)
- Auxin inducibility and developmental expression of axi 1: a gene directing auxin independent growth in tobacco protoplasts (2013) (0)
- Site-specific deoxynucleotide substitutions in yeast U 6 snRNA block splicing of pre-mRNA in vitro process of spliceosome (2013) (0)
- Single Molecule FRET Characterization of Pre-mRNA Splicing: Substrate Dynamics during Recognition and Catalysis (2012) (0)
- CRYSTAL STRUCTURE OF THE TRNA SPLICING ENDONUCLEASE FROM METHANOCOCCUS JANNASCHII (1999) (0)
- Temperature-sensitive splicing mutants in yeast (1987) (0)
- Fractionation and characterization of a yeast mRNA splicing extract ( small nudear RNAs / " spliceosome " ) (2003) (0)
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