John Blenis

Q: What Schools Are Affiliated With John Blenis

John Blenis is affiliated with the following schools: McGill University, Yale University, University of Oxford, Weill Cornell Medicine, University of Colorado, Michigan State University, University of California, San Francisco, Harvard University

John Blenis's AcademicInfluence.com Rankings

John Blenis

Medical

#1153

World Rank

#1464

Historical Rank

Pharmacology

#82

World Rank

#107

Historical Rank

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Medical

John Blenis's Degrees

PhD Pharmacology University of California, San Francisco
Doctorate Medicine Harvard University

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John Blenis's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor (1999) (6655)
Molecular mechanisms of mTOR-mediated translational control (2009) (2363)
ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions (2004) (2348)
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. (2002) (1547)
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation. (2011) (1473)
Signal transduction via the MAP kinases: proceed at your own RSK. (1993) (1247)
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression (2004) (1244)
Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb (2003) (1183)
Nuclear localization and regulation of erk- and rsk-encoded protein kinases (1992) (1148)
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases (1992) (1120)
Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation (1994) (1120)
mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events (2005) (1119)
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. (2002) (1060)
Molecular interpretation of ERK signal duration by immediate early gene products (2002) (972)
Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation (2018) (905)
mTOR Controls Cell Cycle Progression through Its Cell Growth Effectors S6K1 and 4E-BP1/Eukaryotic Translation Initiation Factor 4E (2004) (842)
ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK (1992) (833)
Cutting Edge: Different Toll-Like Receptor Agonists Instruct Dendritic Cells to Induce Distinct Th Responses via Differential Modulation of Extracellular Signal-Regulated Kinase-Mitogen-Activated Protein Kinase and c-Fos 1 (2003) (823)
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling (2002) (817)
Rapamycin: one drug, many effects. (2014) (808)
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation (2008) (801)
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. (2004) (768)
PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase (1994) (739)
The RSK family of kinases: emerging roles in cellular signalling (2008) (724)
RAS/ERK Signaling Promotes Site-specific Ribosomal Protein S6 Phosphorylation via RSK and Stimulates Cap-dependent Translation* (2007) (721)
MAPK signal specificity: the right place at the right time. (2006) (706)
Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling (2011) (665)
STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation (1997) (637)
Cargo of Kinesin Identified as Jip Scaffolding Proteins and Associated Signaling Molecules (2001) (621)
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/− mice (2001) (616)
Requirement of serine phosphorylation for formation of STAT-promoter complexes. (1995) (591)
Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade (1998) (583)
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase (1992) (579)
Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance (2005) (574)
Death Receptor Recruitment of Endogenous Caspase-10 and Apoptosis Initiation in the Absence of Caspase-8* (2001) (561)
A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1 (1996) (560)
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity (2006) (526)
Identification of a Conserved Motif Required for mTOR Signaling (2002) (487)
TOS Motif-Mediated Raptor Binding Regulates 4E-BP1 Multisite Phosphorylation and Function (2003) (485)
The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4 (2013) (482)
Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals. (2001) (461)
Caspase-8 Is Required for Cell Death Induced by Expanded Polyglutamine Repeats (1999) (430)
pp90rsk1 Regulates Estrogen Receptor-Mediated Transcription through Phosphorylation of Ser-167 (1998) (382)
SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. (2013) (375)
Identification of S6 Kinase 1 as a Novel Mammalian Target of Rapamycin (mTOR)-phosphorylating Kinase* (2005) (348)
A Network of Immediate Early Gene Products Propagates Subtle Differences in Mitogen-Activated Protein Kinase Signal Amplitude and Duration (2004) (341)
mTOR, translational control and human disease. (2005) (329)
Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase. (1993) (326)
The 70 kDa S6 Kinase Complexes with and Is Activated by the Rho Family G Proteins Cdc42 and Rac1 (1996) (318)
SKAR Links Pre-mRNA Splicing to mTOR/S6K1-Mediated Enhanced Translation Efficiency of Spliced mRNAs (2008) (301)
Rsk1 mediates a MEK–MAP kinase cell survival signal (2000) (299)
ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events. (2010) (292)
The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling. (1995) (283)
The Signal-Dependent Coactivator CBP Is a Nuclear Target for pp90RSK (1996) (279)
PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex. (2015) (275)
A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity (1993) (273)
Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. (2010) (259)
Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation. (1994) (258)
A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases. (1988) (237)
A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. (2010) (234)
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signaling to suppress tumorigenesis (2013) (231)
Nutrient regulation of the mTOR Complex 1 signaling pathway (2013) (230)
Inactivation of the Tuberous Sclerosis Complex-1 and -2 Gene Products Occurs by Phosphoinositide 3-Kinase/Akt-dependent and -independent Phosphorylation of Tuberin* (2003) (223)
Evidence for MEK-independent pathways regulating the prolonged activation of the ERK-MAP kinases (1997) (213)
Coordinate regulation of translation by the PI 3-kinase and mTOR pathways. (2002) (212)
Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors. (2005) (207)
The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation (2014) (205)
Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1 (2008) (204)
Evidence for two catalytically active kinase domains in pp90rsk (1996) (203)
p70 S6 Kinase Is Regulated by Protein Kinase Cζ and Participates in a Phosphoinositide 3-Kinase-Regulated Signalling Complex (1999) (203)
Not all substrates are treated equally: Implications for mTOR, rapamycin-resistance, and cancer therapy (2009) (199)
The RSK factors of activating the Ras/MAPK signaling cascade. (2008) (199)
SKAR Is a Specific Target of S6 Kinase 1 in Cell Growth Control (2004) (199)
Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers (2016) (198)
Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. (2013) (198)
Phosphorylation of p90 Ribosomal S6 Kinase (RSK) Regulates Extracellular Signal-Regulated Kinase Docking and RSK Activity (2003) (195)
PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration. (2004) (188)
Neurotransmitter- and Growth Factor-Induced cAMP Response Element Binding Protein Phosphorylation in Glial Cell Progenitors: Role of Calcium Ions, Protein Kinase C, and Mitogen-Activated Protein Kinase/Ribosomal S6 Kinase Pathway (1997) (186)
Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways (2006) (184)
Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex. (2013) (178)
Phosphorylation of c-Fos at the C-terminus enhances its transforming activity. (1996) (176)
Ribosomal S6 Kinase (RSK) Regulates Phosphorylation of Filamin A on an Important Regulatory Site (2004) (176)
Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP (1995) (173)
Characterization of S6K2, a novel kinase homologous to S6K1 (1999) (166)
Essential Role for Caspase-8 in Transcription-independent Apoptosis Triggered by p53* (2000) (160)
ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex. (2011) (149)
Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway (1995) (148)
Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation (2011) (148)
The Tumor Suppressor DAP Kinase Is a Target of RSK-Mediated Survival Signaling (2005) (144)
Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK (1999) (141)
PI3-kinase and TOR: PIKTORing cell growth. (2004) (137)
Functional domains and phosphorylation of the orphan receptor Nur77. (1993) (130)
Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling (2017) (128)
Structural and functional analysis of pp70S6k. (1995) (127)
Deletion of Ribosomal S6 Kinases Does Not Attenuate Pathological, Physiological, or Insulin-Like Growth Factor 1 Receptor-Phosphoinositide 3-Kinase-Induced Cardiac Hypertrophy (2004) (120)
p42 mitogen-activated protein kinase and p90 ribosomal S6 kinase are selectively phosphorylated and activated during thrombin-induced platelet activation and aggregation (1994) (119)
Identification of Xenopus S6 protein kinase homologs (pp90rsk) in somatic cells: phosphorylation and activation during initiation of cell proliferation (1990) (119)
The Pleckstrin Homology Domain in Insulin Receptor Substrate-1 Sensitizes Insulin Signaling (*) (1995) (114)
Characterization of Regulatory Events Associated with Membrane Targeting of p90 Ribosomal S6 Kinase 1 (2001) (113)
Spatially Separate Docking Sites on ERK2 Regulate Distinct Signaling Events In Vivo (2005) (112)
Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells (2014) (109)
Graded Mitogen-Activated Protein Kinase Activity Precedes Switch-Like c-Fos Induction in Mammalian Cells (2005) (107)
Cloning and Characterization of a Human STE20-like Protein Kinase with Unusual Cofactor Requirements* (1997) (106)
Unique Metabolic Adaptations Dictate Distal Organ-Specific Metastatic Colonization. (2018) (104)
Analysis of mTOR signaling by the small G‐proteins, Rheb and RhebL1 (2005) (103)
Regulation of pp90rsk phosphorylation and S6 phosphotransferase activity in Swiss 3T3 cells by growth factor-, phorbol ester-, and cyclic AMP-mediated signal transduction (1991) (103)
AKT Facilitates EGFR Trafficking and Degradation by Phosphorylating and Activating PIKfyve (2013) (99)
Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity. (1991) (97)
The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue (2016) (97)
Distinct mechanisms for the activation of the RSK kinases/MAP2 kinase/pp90rsk and pp70-S6 kinase signaling systems are indicated by inhibition of protein synthesis. (1991) (94)
YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites (1996) (94)
The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis (1996) (93)
Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1. (2014) (91)
Failure of rapamycin to block proliferation once resting cells have entered the cell cycle despite inactivation of p70 S6 kinase. (1993) (90)
Activation of MAP kinases, pp90rsk and pp70‐S6 kinases in mouse mast cells by signaling through the c‐kit receptor tyrosine kinase or FcϵRI: rapamycin inhibits activation of pp70‐S6 kinase and proliferation in mouse mast cells (1993) (88)
p90 Ribosomal S6 Kinase and p70 Ribosomal S6 Kinase Link Phosphorylation of the Eukaryotic Chaperonin Containing TCP-1 to Growth Factor, Insulin, and Nutrient Signaling* (2009) (86)
Distinct roles for mammalian target of rapamycin complexes in the fibroblast response to transforming growth factor-beta. (2009) (84)
mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation. (2018) (82)
A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase (1997) (82)
Characterization of Phosphatidylinositol 3-Kinase-dependent Phosphorylation of the Hydrophobic Motif Site Thr389 in p70 S6 Kinase 1* (2002) (82)
Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes. (1993) (79)
Regulation of a ribosomal protein S6 kinase activity by the Rous sarcoma virus transforming protein, serum, or phorbol ester. (1985) (77)
Ran-binding protein 3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport. (2008) (75)
Cell signaling in protein synthesis ribosome biogenesis and translation initiation and elongation. (2009) (74)
The p70S6K signalling pathway: a novel signalling system involved in growth regulation. (1996) (73)
A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways. (2015) (71)
Fas-associated Death Domain Protein (FADD) and Caspase-8 Mediate Up-regulation of c-Fos by Fas Ligand and Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) via a FLICE Inhibitory Protein (FLIP)-regulated Pathway* (2001) (70)
ERK reinforces actin polymerization to power persistent edge protrusion during motility (2015) (70)
Beyond the Warburg Effect: How Do Cancer Cells Regulate One-Carbon Metabolism? (2018) (70)
Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3 (2014) (68)
TORgeting oncogene addiction for cancer therapy. (2006) (68)
Inhibition of ERK‐MAP kinase signaling by RSK during Drosophila development (2006) (66)
ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate. (2015) (66)
Identification of a ribosomal protein S6 kinase regulated by transformation and growth-promoting stimuli. (1987) (66)
The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins (1998) (65)
Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells (2018) (65)
Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells (2014) (63)
Hippo–YAP and mTOR pathways collaborate to regulate organ size (2012) (62)
Characterization of a Conserved C-terminal Motif (RSPRR) in Ribosomal Protein S6 Kinase 1 Required for Its Mammalian Target of Rapamycin-dependent Regulation* (2005) (61)
Regulation of protein kinase activities in PC12 pheochromocytoma cells. (1986) (60)
FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation (2014) (59)
Antibodies to Xenopus egg S6 kinase II recognize S6 kinase from progesterone- and insulin-stimulated Xenopus oocytes and from proliferating chicken embryo fibroblasts (1987) (59)
Female Sex and Gender in Lung/Sleep Health and Disease. Increased Understanding of Basic Biological, Pathophysiological, and Behavioral Mechanisms Leading to Better Health for Female Patients with Lung Disease (2018) (59)
Stimulation of ribosomal protein S6 kinase activity by pp60v-src or by serum: dissociation from phorbol ester-stimulated activity. (1986) (58)
Age-induced accumulation of methylmalonic acid promotes tumour progression (2020) (57)
Coordinate regulation of pp90rsk and a distinct protein-serine/threonine kinase activity that phosphorylates recombinant pp90rsk in vitro (1991) (55)
TOR, the Gateway to Cellular Metabolism, Cell Growth, and Disease (2017) (55)
ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation (2019) (54)
Heat shock induces two distinct S6 protein kinase activities in quiescent mammalian fibroblasts (1991) (52)
Integration of mTOR and estrogen–ERK2 signaling in lymphangioleiomyomatosis pathogenesis (2013) (52)
Phorbol ester, serum, and rous sarcoma virus transforming gene product induce similar phosphorylations of ribosomal protein S6. (1984) (52)
Down-regulation of CMTM8 Induces Epithelial-to-Mesenchymal Transition-like Changes via c-MET/Extracellular Signal-regulated Kinase (ERK) Signaling* (2012) (51)
Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells (2014) (51)
Disruption of 3-Phosphoinositide-dependent Kinase 1 (PDK1) Signaling by the Anti-tumorigenic and Anti-proliferative AgentN-α-tosyl-l-phenylalanyl Chloromethyl Ketone* (2001) (51)
Growth-regulated signal transduction by the MAP kinases and RSKs. (1991) (49)
Transformation-sensitive protein associated with the cell substratum of chicken embryo fibroblasts. (1983) (47)
PHLPPing it off: phosphatases get in the Akt. (2007) (46)
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. (2019) (46)
Phosphorylation of the ribosomal protein S6 is elevated in cells transformed by a variety of tumor viruses (1984) (45)
Granulocyte-macrophage colony-stimulating factor stimulation results in phosphorylation of cAMP response element-binding protein through activation of pp90RSK. (2000) (43)
Growth control in cultured 3T3 fibroblasts II. Molecular properties of a fraction enriched in growth inhibitory activity (1982) (41)
Characterization of a transformation-sensitive protein in the extracellular matrix of chicken embryo fibroblasts. (1984) (41)
EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYC. (2018) (39)
Mind the GAP: Wnt Steps onto the mTORC1 Train (2006) (39)
Subcellular localization specified by protein acylation and phosphorylation. (1993) (38)
Dominant mutations confer resistance to the immunosuppressant, rapamycin, in variants of a T cell lymphoma. (1995) (38)
A Drosophila gene structurally and functionally homologous to the mammalian 70-kDa s6 kinase gene. (1996) (38)
Cytoplasmic to nuclear signal transduction by mitogen-activated protein kinase and 90 kDa ribosomal S6 kinase. (1993) (36)
Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells (2014) (36)
Relationship between multiple biologic effects of rapamycin and the inhibition of pp70S6 protein kinase activity. Analysis in mutant clones of a T cell lymphoma. (1994) (32)
A high-throughput, cell-based screening method for siRNA and small molecule inhibitors of mTORC1 signaling using the In Cell Western technique. (2010) (31)
Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability (2020) (31)
mTORC1-chaperonin CCT signaling regulates m6A RNA methylation to suppress autophagy (2021) (31)
Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition. (2017) (31)
A Specific Mechanomodulatory Role for p38 MAPK in Embryonic Joint Articular Surface Cell MEK-ERK Pathway Regulation* (2006) (31)
Studies of partially transforming polyomavirus mutants establish a role for phosphatidylinositol 3-kinase in activation of pp70 S6 kinase (1996) (30)
ERK2/Fra1/ZEB pathway induces epithelial-to-mesenchymal transition (2010) (30)
The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer (2018) (29)
The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro (2020) (28)
Characterizing the interaction of the mammalian eIF4E‐related protein 4EHP with 4E‐BP1 (2004) (27)
mTORC1 promotes cell growth via m6A-dependent mRNA degradation. (2021) (26)
SHP-2 Regulates Cell Growth by Controlling the mTOR/S6 Kinase 1 Pathway* (2007) (24)
Rheb activation of mTOR and S6K1 signaling. (2006) (23)
Activation of early growth response 1 gene transcription and pp90rsk during induction of monocytic differentiation. (1994) (23)
Inhibition of p70/p85 S6 kinase activities in T cells by dexamethasone. (1996) (22)
Age-induced methylmalonic acid accumulation promotes tumor progression (2020) (22)
Regulates Glutamine Metabolism through the eIF 4 B-Dependent Control of c-Myc Translation (2014) (22)
mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress. (2016) (21)
Activation of the early growth response 1 gene and nuclear pp90rsk in human myeloid leukemia cells by 1-(beta-D-arabinofuranosyl)cytosine. (1993) (21)
Quantitative Phosphoproteomic Analysis Identifies the Adaptor Protein Grb 10 as an mTORC 1 Substrate that Negatively Regulates Insulin Signaling (2011) (20)
Appetite for destruction: the inhibition of glycolysis as a therapy for tuberous sclerosis complex-related tumors (2011) (20)
The effect of mannose6-phosphate on the turnover of cell surface glycosaminoglycans. (1983) (19)
EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer (2017) (19)
Deletion of Ribosomal S 6 Kinases Does Not Attenuate Pathological , Physiological , or Insulin-Like Growth Factor 1 Receptor – Phosphoinositide 3-Kinase-Induced Cardiac Hypertrophy (2004) (18)
Fos Kinase-Mitogen-Activated Protein Kinase Signal-RegulatedModulation of Extracellular Distinct Th Responses via Differential Agonists Instruct Dendritic Cells to Induce Cutting Edge : Different Toll-Like Receptor (2003) (18)
p90 ribosomal S6 kinase (RSK) phosphorylates myosin phosphatase and thereby controls edge dynamics during cell migration (2019) (18)
Regulation of GSK3 cellular location by FRAT modulates mTORC1-dependent cell growth and sensitivity to rapamycin (2019) (16)
An atlas of substrate specificities for the human serine/threonine kinome (2023) (15)
Polyomavirus middle T antigen induces ribosomal protein S6 phosphorylation through pp60c-src-dependent and -independent pathways (1988) (15)
Correction for Mullarky et al., Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers (2016) (14)
Construction and characterization of a cDNA clone containing a portion of the bovine prolactin sequence. (1980) (14)
Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis (2019) (14)
NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma. (2021) (14)
Grb 10 Promotes Lipolysis and Thermogenesis by Phosphorylation-Dependent Feedback Inhibition of mTORC 1 (2014) (13)
mTORC1 signaling aids in CADalyzing pyrimidine biosynthesis. (2013) (9)
Altered propionate metabolism contributes to tumor progression and aggressiveness (2022) (9)
Chapter 2 Cell Signaling in Protein Synthesis (2009) (9)
ATM: Promoter of metabolic "cost" reduction and "savings" usage during hypoxia through mTORC1 regulation. (2010) (9)
Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer. (2017) (9)
Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells (Proceedings of the National Academy of Sciences of the United States of America (2014) 111 (E2182-E2190) DOI: 10.1073/pnas.1404943111) (2014) (8)
The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4 (2021) (8)
A global atlas of substrate specificities for the human serine/threonine kinome (2022) (8)
Structural and functional analysis of pp 70 S 6 k (2005) (7)
mTORC1-Mediated Control of Protein Translation (2010) (7)
Molecular analyses of gene products associated with the response of cells to mitogenic stimulation. (1988) (7)
Akt-ivation of RNA splicing. (2014) (7)
MAPK Signaling in Human Diseases (2006) (7)
Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis. (2016) (7)
Erratum: Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers (Proceedings of the National Academy of Sciences of the United States of America (2016) 113 (1778-1783) DOI:10.1073/pnas.1521548113) (2016) (6)
Granulocyte-macrophage colony-stimulating factor stimulation results in phosphorylation of cAMP response element-binding protein through activation of pp 90 RSK (2000) (6)
Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication (2022) (5)
mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events (2021) (5)
ERK-MAP Kinase signaling in the cytoplasm. (2010) (5)
Inhibition of osteoclasts differentiation by CDC2-induced NFATc1 phosphorylation. (2019) (5)
Detection of transformed cells using a fluorescent probe: the molecular basis for the differential reaction of fluorescamine with normal and transformed cells. (1982) (5)
Seeing mTORC1 specificity (2016) (4)
PNAS Plus Significance Statements (2016) (4)
TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine‐directed cysteine residues (2012) (4)
Structural Insights into the Activation of mTORC1 on the Lysosomal Surface. (2020) (4)
Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb (2022) (4)
Role of second messengers in regulating the growth-associated S6 protein kinase activity. (1987) (3)
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment (2022) (3)
Targeting the premetastatic niche: epigenetic therapies in the spotlight (2020) (3)
-Dependent Activation of the mTORC2 Kinase Complex (2015) (3)
Prolonged deprivation of arginine or leucine induces PI3K/Akt-dependent reactivation of mTORC1 (2022) (3)
A Xenopus ribosomal protein S 6 kinase has two apparent kinase domains that are each similar to distinct protein kinases ( S 6 phosphorylation / growth control / conserved protein sequences ) (2003) (2)
Dissociation of pp 70 Ribosomal Protein S 6 Kinase from Insulin-stimulated Glucose Transport in 3 T 3-Ll Adipocytes * (2001) (2)
Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells (2022) (2)
mTORC1: A Signaling Integration Node Involved in Cell Growth (2009) (1)
Identification and characterization of the mediator kinase-dependent myometrial stem cell phosphoproteome. (2021) (1)
Histone H3 variants at the root of metastasis (2020) (1)
AKTs do not translocate to the nucleus upon stimulation but AKT3 can constitutively signal from the nuclear envelope. (2022) (1)
Acknowledgment of Guest Editors, 2019 (2019) (1)
Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression (2022) (1)
TRANSFORMATION SPECIFIC PROTEIN OF THE EXTRACELLULAR MATRIX1 (1982) (1)
164 INVITED mTOR-S6K1 signaling and cell growth control (2007) (1)
Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability (2020) (1)
Targeting mTOR in the context of diet and whole-body metabolism. (2022) (1)
TheRas-ERKandPI3K-mTORpathways: cross-talk and compensation (2011) (1)
DOWN-REGULATION OF CMTM8 INDUCES EMT-LIKE CHANGES VIA C-MET/ERK SIGNALING (2012) (0)
mTOR Complex 1, Metabolism and Cell Growth Control (2013) (0)
NADK is Activated by Oncogenic KRAS Signaling to Sustain Pancreatic Ductal Adenocarcinoma (2020) (0)
Abstract 2378: Methylmalonic acid is elevated in non-small cell lung cancer and promotes drug resistance (2022) (0)
PNAS Plus Significance Statements (2014) (0)
Coordinate Regulation of ppgOrsk and a Distinct Protein-Serine/Threonine Kinase Activity That Phosphorylates Recombinant pp9Orsk In Vitro (2003) (0)
Abstract 3175: Methylmalonic acid in TME signaling (2022) (0)
Roles of Amylin in Diabetes and in Regulation of Nutrient Load (1998) (0)
Regulation of ppgorsk Phosphorylation and S6 Phosphotransferase Activity in Swiss 3T3 Cells by Growth Factor-, Phorbol Ester-, and Cyclic AMP-Mediated Signal Transduction (2003) (0)
Abstract SY09-01: Control of class III PI 3-kinase in autophagy and cancers (2011) (0)
EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer (2017) (0)
Kinase-Mitogen-Activated Protein Kinase Signal-Regulated Modulation of Extracellular Distinct Th Responses via Differential Agonists Instruct Dendritic Cells to Induce Cutting Edge: Different Toll-Like Receptor (2003) (0)
and rsk-encoded protein kinases. Nuclear localization and regulation of erk- (2013) (0)
Stimulation of ribosomal protein S 6 kinase activity by pp 6 Ov-src or by serum : Dissociation from phorbol ester-stimulated activity ( Rous sarcoma virus / growth factors / protein kinase C / cydoheximide / vanadate ) (2003) (0)
Metabolism Mini Symposium (2013) (0)
Retraction for Li et al., Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells (2023) (0)
Age-induced methylmalonic acid accumulation promotes tumor progression and aggressiveness (2020) (0)
Abstract SY29-01: mTOR, metabolism, and cell growth control (2012) (0)
Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation (2018) (0)
Phosphorylation oftheRibosomal Protein S6IsElevated inCells Transformed bya Variety ofTumorViruses (1984) (0)
Abstract IA12: Coordination of mRNA processing, translation, and metabolism by mTORC1 (2020) (0)
Raymond L. Erikson (1936–2020) (2020) (0)
Abstract 162: Identification of novel targets of Serine/arginine-rich protein-specific kinase 2 (2022) (0)
Age-induced accumulation of methylmalonic acid promotes tumour progression (2020) (0)
Correction for “ Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1 / CXCR 4 in breast cancer stem cells (2014) (0)
Financial support: J. Li is a Tuberous Sclerosis Alliance Postdoctoral Fellow (2016) (0)
Abstract B09: Aspirin inhibits cyclooxygenase 2-mediated prostaglandin production and tumorigenesisin a preclinical model of tuberous sclerosis complex (2014) (0)
Regulation of the immediate early gene product c-Fos by ERK and RSK: a mechanism for sensing and propagating ERK signal duration (2002) (0)
Abstract IA03: mTORC1/S6K1: Regulation of RNA biogenesis, protein synthesis, and cell metabolism (2017) (0)
Editorial Note to: Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply. (2021) (0)
O-28: Characterization of IRS-1 molecules containing single SH2-protein binding determinants (2009) (0)
Correction for McMullen et al., “Deletion of Ribosomal S6 Kinases Does Not Attenuate Pathological, Physiological, or Insulin-Like Growth Factor 1 Receptor–Phosphoinositide 3-Kinase-Induced Cardiac Hypertrophy” (2021) (0)
Abstract B10: Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in tuberous sclerosis complex (2015) (0)
Cell Growth Regulation by PI3‐kinase, Ras and mTOR Signal Integration (2006) (0)
and John Blenis Amplitude and Duration Mitogen-Activated Protein Kinase Signal Products Propagates Subtle Differences in A Network of Immediate Early Gene (2003) (0)
Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis (2019) (0)
Abstract C59: Estradiol and mTORC2 orchestrate to enhance prostaglandin biosynthesis andtumorigenesis in tuberous sclerosis complex (2013) (0)
Phosphorylation-dephosphorylation events in cells transformed by Rous sarcoma virus (1985) (0)
Abstract PR05: Regulation of mRNA N6-adenosine methylation by the mTOR signaling (2020) (0)
FLCN is a novel regulator of autophagy 1 FLCN , a novel autophagy component , interacts with GABARAP and is regulated by ULK 1 1 phosphorylation 2 3 (2014) (0)
Referees 1997 (1997) (0)

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What Schools Are Affiliated With John Blenis?

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