John C. Marshall

John C. Marshall's AcademicInfluence.com Rankings

John C. Marshall

Medical

#908

World Rank

#1171

Historical Rank

Epidemiology

#117

World Rank

#128

Historical Rank

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John C. Marshall

Philosophy

#3218

World Rank

#5254

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Logic

#1018

World Rank

#1636

Historical Rank

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John C. Marshall's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). (2016) (13437)
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference (2003) (4955)
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference (2003) (4227)
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008 (2007) (4099)
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008 (2008) (3717)
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 (2017) (3647)
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2016 (2017) (2976)
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock (2004) (2604)
Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. (1995) (2458)
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock (2004) (1702)
Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis. (2020) (1694)
No surgical innovation without evaluation: the IDEAL recommendations (2009) (1430)
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis (2010) (1419)
Critically ill patients with 2009 influenza A(H1N1) infection in Canada. (2009) (1418)
Drotrecogin alfa (activated) in adults with septic shock. (2012) (1154)
Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 (2021) (1105)
A minimal common outcome measure set for COVID-19 clinical research (2020) (939)
Safety of Cell Therapy with Mesenchymal Stromal Cells (SafeCell): A Systematic Review and Meta-Analysis of Clinical Trials (2012) (926)
Recombinant Human Interleukin 1 Receptor Antagonist in the Treatment of Patients With Sepsis Syndrome: Results From a Randomized, Double-blind, Placebo-Controlled Trial (1994) (889)
Risk factors for gastrointestinal bleeding in critically ill patients (1994) (878)
Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit. (2014) (822)
Multiple-organ-failure syndrome. (1986) (772)
Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. (2003) (680)
A comparison of sucralfate and ranitidine for the prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care Trials Group. (1998) (672)
Is a low transfusion threshold safe in critically ill patients with cardiovascular diseases? (2001) (610)
Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. (2004) (607)
Sepsis definitions: time for change (2013) (572)
Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis. (2013) (558)
Why have clinical trials in sepsis failed? (2014) (542)
Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19 (2021) (508)
Age of transfused blood in critically ill adults. (2015) (508)
Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19 (2021) (485)
Inflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction syndrome (2001) (455)
The Gastrointestinal Tract The “Undrained Abscess” of Multiple Organ Failure (1993) (437)
The surviving sepsis campaign. (2006) (435)
The Surviving Sepsis Campaign: Results of an international guideline-based performance improvement program targeting severe sepsis* (2010) (427)
Withdrawal of mechanical ventilation in anticipation of death in the intensive care unit. (2003) (414)
Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis. (2021) (391)
Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab′)2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels* (2004) (366)
Dysregulated expression of neutrophil apoptosis in the systemic inflammatory response syndrome. (1997) (351)
The microbiology of multiple organ failure. The proximal gastrointestinal tract as an occult reservoir of pathogens. (1988) (324)
CARING FOR THE CRITICALLY ILL PATIENT Critically Ill Patients With 2009 Influenza A ( H 1 N 1 ) Infection in Canada (2009) (313)
Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study. (2004) (308)
Selective decontamination of the digestive tract in surgical patients: a systematic review of the evidence. (1999) (301)
What is an intensive care unit? A report of the task force of the World Federation of Societies of Intensive and Critical Care Medicine (2017) (290)
Such stuff as dreams are made on: mediator-directed therapy in sepsis (2003) (283)
Multiple Organ Dysfunction Score (1996) (279)
Conservative fluid management or deresuscitation for patients with sepsis or acute respiratory distress syndrome following the resuscitation phase of critical illness: a systematic review and meta-analysis (2017) (268)
Measures, markers, and mediators: Toward a staging system for clinical sepsis. A Report of the Fifth Toronto Sepsis Roundtable, Toronto, Ontario, Canada, October 25–26, 2000 (2003) (263)
Risk factors for clinically important upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care Trials Group. (1999) (263)
Prevalence and Outcomes of Infection Among Patients in Intensive Care Units in 2017. (2020) (263)
The RECOVER Program: Disability Risk Groups and 1-Year Outcome after 7 or More Days of Mechanical Ventilation. (2016) (238)
Clinician predictions of intensive care unit mortality* (2004) (238)
Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level: The EUPHRATES Randomized Clinical Trial (2018) (232)
Neutrophil apoptosis is modulated by endothelial transmigration and adhesion molecule engagement. (1997) (232)
Source control in the management of severe sepsis and septic shock: An evidence-based review (2004) (232)
Immunomodulatory effects of hypertonic resuscitation on the development of lung inflammation following hemorrhagic shock. (1998) (226)
Subcutaneous Heparin Versus Low-Molecular-Weight Heparin as Thromboprophylaxis in Patients Undergoing Colorectal Surgery: Results of the Canadian Colorectal DVT Prophylaxis Trial: A Randomized, Double-Blind Trial (2001) (224)
Biomarkers of sepsis (2009) (211)
Hemorrhagic shock primes for increased expression of cytokine-induced neutrophil chemoattractant in the lung: role in pulmonary inflammation following lipopolysaccharide. (1998) (206)
Tertiary Peritonitis: Clinical Features of a Complex Nosocomial Infection (1993) (199)
Higher Fluid Balance Increases the Risk of Death From Sepsis: Results From a Large International Audit* (2017) (197)
Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity* (2004) (191)
Impact of a clinical pharmacist-enforced intensive care unit sedation protocol on duration of mechanical ventilation and hospital stay* (2008) (190)
Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages (2006) (189)
Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injury (2006) (181)
The prevention of substance use, risk and harm in Australia - a review of the evidence (2004) (181)
Intensive care unit management of intra-abdominal infection (2003) (178)
Impact of compliance with infection management guidelines on outcome in patients with severe sepsis: a prospective observational multi-center study (2014) (175)
Biomarkers of sepsis: time for a reappraisal (2020) (173)
Increased mortality associated with methicillin-resistant Staphylococcus aureus (MRSA) infection in the intensive care unit: results from the EPIC II study. (2011) (170)
Source control in the management of sepsis (2001) (167)
The Clinical Utility of Invasive Diagnostic Techniques in the Setting of Ventilator-Associated Pneumonia* (1999) (167)
Measurement of endotoxin activity in critically ill patients using whole blood neutrophil dependent chemiluminescence (2002) (163)
Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin dalteparin: an assessment of safety and pharmacodynamics: the DIRECT study. (2008) (160)
Transfusion requirements in critical care : a pilot study (1995) (157)
The IL-1β-Converting Enzyme (Caspase-1) Inhibits Apoptosis of Inflammatory Neutrophils Through Activation of IL-1β (1998) (154)
Is a restrictive transfusion strategy safe for resuscitated and critically ill trauma patients? (2004) (151)
A Comparison of Sucralfate and Ranitidine for the Prevention of Upper Gastrointestinal Bleeding in Patients Requiring Mechanical Ventilation (1999) (150)
Sepsis: rethinking the approach to clinical research (2008) (147)
Outcome measures for clinical research in sepsis: A report of the 2nd Cambridge Colloquium of the International Sepsis Forum (2005) (147)
The Age of Blood Evaluation (ABLE) randomized controlled trial: study design. (2011) (146)
A rapid assay of endotoxin in whole blood using autologous neutrophil dependent chemiluminescence. (1998) (141)
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008 (2008) (135)
Predisposition, insult/infection, response, and organ dysfunction: A new model for staging severe sepsis (2009) (131)
The efficacy and safety of plasma exchange in patients with sepsis and septic shock: a systematic review and meta-analysis (2014) (131)
Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 - Preliminary report (2021) (131)
Effects of fluid resuscitation with synthetic colloids or crystalloids alone on shock reversal, fluid balance, and patient outcomes in patients with severe sepsis: A prospective sequential analysis* (2012) (129)
Cardiopulmonary resuscitation directives on admission to intensive-care unit: an international observational study (2001) (129)
Regulation of Toll-Like Receptor 4 Expression in the Lung Following Hemorrhagic Shock and Lipopolysaccharide1 (2002) (127)
Cell therapy with intravascular administration of mesenchymal stromal cells continues to appear safe: An updated systematic review and meta-analysis (2020) (126)
Ten reasons why we should NOT use severity scores as entry criteria for clinical trials or in our treatment decisions* (2010) (126)
Addressing the question of the effect of RBC storage on clinical outcomes: the Red Cell Storage Duration Study (RECESS) (Section 7). (2010) (125)
Variation in red cell transfusion practice in the intensive care unit: a multicentre cohort study (1999) (121)
Effect of a multifaceted educational intervention for anti-infectious measures on sepsis mortality: a cluster randomized trial (2017) (121)
Interaction Between Fluids and Vasoactive Agents on Mortality in Septic Shock: A Multicenter, Observational Study* (2014) (117)
PRECLINICAL MODELS OF SHOCK AND SEPSIS: WHAT CAN THEY TELL US? (2005) (117)
Clinical trials of mediator-directed therapy in sepsis: what have we learned? (2000) (114)
Relationship of catheter-associated urinary tract infection to mortality and length of stay in critically ill patients: A systematic review and meta-analysis of observational studies (2011) (113)
Should morbidity replace mortality as an endpoint for clinical trials in intensive care? (1995) (113)
Multinational, observational study of procalcitonin in ICU patients with pneumonia requiring mechanical ventilation: a multicenter observational study (2011) (111)
Empiric antibiotic therapy for suspected ventilator-associated pneumonia: A systematic review and meta-analysis of randomized trials (2008) (111)
Regulation of Fas antibody induced neutrophil apoptosis is both caspase and mitochondrial dependent (1999) (107)
Maternal neutrophil apoptosis in normal pregnancy, preeclampsia, and normotensive intrauterine growth restriction. (1999) (107)
Thiol-mediated redox regulation of neutrophil apoptosis. (1996) (107)
Cellular Immunotherapy for Septic Shock. A Phase I Clinical Trial (2017) (107)
Efficacy of Mesenchymal Stromal Cell Therapy for Acute Lung Injury in Preclinical Animal Models: A Systematic Review (2016) (106)
Burden of illness in venous thromboembolism in critical care: a multicenter observational study. (2005) (105)
NEUTRALIZATION OF TUMOR NECROSIS FACTOR IN PRECLINICAL MODELS OF SEPSIS (2005) (105)
SIRS and MODS: what is their relevance to the science and practice of intensive care? (2000) (102)
Pyrrolidine dithiocarbamate attenuates endotoxin-induced acute lung injury. (1997) (102)
Augmented intracellular glutathione inhibits Fas-triggered apoptosis of activated human neutrophils. (1997) (100)
Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock (2008) (98)
Research recruitment practices and critically ill patients. A multicenter, cross-sectional study (the Consent Study). (2013) (95)
Deresuscitation of Patients With Iatrogenic Fluid Overload Is Associated With Reduced Mortality in Critical Illness* (2018) (93)
The influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness (2016) (92)
The gut as a potential trigger of exercise-induced inflammatory responses. (1998) (89)
Therapeutic Anticoagulation in Critically Ill Patients with Covid-19-Preliminary Report (2021) (88)
The Devil Is in the Details: Incomplete Reporting in Preclinical Animal Research (2016) (86)
Minimum Quality Threshold in Pre-Clinical Sepsis Studies (Mqtipss): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis (2018) (85)
Abdominal infections in the intensive care unit: characteristics, treatment and determinants of outcome (2014) (85)
Gastrointestinal flora and its alterations in critical illness. (1999) (79)
Anticoagulant interventions in hospitalized patients with COVID‐19: A scoping review of randomized controlled trials and call for international collaboration (2020) (78)
Twenty-five percent albumin prevents lung injury following shock/resuscitation (2003) (78)
Phagocytosis of Candida albicans induces apoptosis of human neutrophils. (2000) (77)
Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis (2018) (77)
Dynamic Regulation of Neutrophil Survival through Tyrosine Phosphorylation or Dephosphorylation of Caspase-8* (2008) (77)
A path to precision in the ICU (2017) (76)
Lipopolysaccharide: an endotoxin or an exogenous hormone? (2005) (74)
Priming for enhanced alveolar fibrin deposition after hemorrhagic shock: role of tumor necrosis factor. (2000) (73)
Withholding Pantoprazole for Stress Ulcer Prophylaxis in Critically Ill Patients: A Pilot Randomized Clinical Trial and Meta-Analysis* (2017) (73)
Antibiotic management of suspected nosocomial ICU-acquired infection: Does prolonged empiric therapy improve outcome? (2007) (70)
Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial (2016) (68)
Impact of selective decontamination of the digestive tract on multiple organ dysfunction syndrome: Systematic review of randomized controlled trials* (2010) (68)
Oxidative Stress Reprograms Lipopolysaccharide Signaling via Src Kinase-dependent Pathway in RAW 264.7 Macrophage Cell Line* (2003) (67)
In vivo and in vitro modulation of intercellular adhesion molecule (ICAM)-1 expression by hypertonicity. (2000) (66)
Understanding and Enhancing Sepsis Survivorship: Priorities for Research and Practice. (2019) (65)
Low-dose steroids in adult septic shock: results of the Surviving Sepsis Campaign (2012) (63)
Neutrophils in the pathogenesis of sepsis. (2005) (63)
Kupffer cell modulation of the systemic immune response. (1987) (62)
The Impact of Multiple Organ Dysfunction on Mortality following RupturedAbdominal Aortic Aneurysm Repair (1998) (62)
The immune system in critical illness. (2008) (62)
The IL-1 beta-converting enzyme (caspase-1) inhibits apoptosis of inflammatory neutrophils through activation of IL-1 beta. (1998) (62)
The design of randomized clinical trials in critically ill patients. (2002) (60)
Murine Hepatitis Virus Strain 3 Induces the Macrophage Prothrombinase fgl-2 through p38 Mitogen-activated Protein Kinase Activation* (1998) (60)
ARDS and the multiple organ dysfunction syndrome. Common mechanisms of a common systemic process. (2002) (60)
Gender Parity in Critical Care Medicine. (2017) (59)
Sepsis, SIRS, and MODS: What’s in a Name? (1996) (59)
The intensive care medicine research agenda on septic shock (2017) (57)
Critical care capacity in Canada: results of a national cross-sectional study (2015) (57)
Intra-abdominal infections. (2004) (56)
How outcomes are defined in clinical trials of mechanically ventilated adults and children. (2014) (56)
Bench-to-bedside review: Clinical experience with the endotoxin activity assay (2012) (56)
Heparin-induced thrombocytopenia in medical surgical critical illness. (2013) (55)
Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study (2018) (54)
The safety of targeted antibiotic therapy for ventilator-associated pneumonia: a multicenter observational study. (2008) (54)
Cost-effectiveness of dalteparin vs unfractionated heparin for the prevention of venous thromboembolism in critically ill patients. (2014) (52)
The Surviving Sepsis Campaign: a history and a perspective. (2010) (52)
Redefining critical illness (2022) (52)
Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. (2022) (52)
Clinical research ethics for critically ill patients: A pandemic proposal (2010) (50)
Prevention of endotoxin-induced mortality by antitissue factor immunization. (1996) (50)
Thiol-mediated regulation of ICAM-1 expression in endotoxin-induced acute lung injury. (1998) (50)
Effects of Mesenchymal Stem Cell Treatment on Systemic Cytokine Levels in a Phase 1 Dose Escalation Safety Trial of Septic Shock Patients* (2019) (49)
Multiple Organ Dysfunction: The Defining Syndrome of Sepsis. (2018) (49)
Part I: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Study Design and Humane Modeling Endpoints. (2019) (49)
The clinical utility of invasive diagnostic techniques in the setting of ventilator-associated pneumonia. Canadian Critical Care Trials Group. (1999) (49)
Impaired apoptotic death signaling in inflammatory lung neutrophils is associated with decreased expression of interleukin-1 beta converting enzyme family proteases (caspases). (1997) (48)
GPIbα is required for platelet-mediated hepatic thrombopoietin generation. (2018) (48)
Synergistic induction of IL-10 by hypertonic saline solution and lipopolysaccharides in murine peritoneal macrophages. (2001) (48)
A Core Outcome Set for Critical Care Ventilation Trials (2013) (48)
The PIRO Concept: O is for organ dysfunction (2003) (48)
Endotoxin in the pathogenesis of sepsis. (2010) (48)
Principles of Source Control in the Early Management of Sepsis (2010) (47)
Small-bowel bacterial overgrowth and systemic immunosuppression in experimental peritonitis. (1988) (47)
A Transcriptomic Biomarker to Quantify Systemic Inflammation in Sepsis — A Prospective Multicenter Phase II Diagnostic Study (2016) (47)
DJ‐1/PARK7 Impairs Bacterial Clearance in Sepsis (2017) (47)
Integrating mortality and morbidity outcomes: using quality-adjusted life years in critical care trials. (2013) (46)
Comparison of the source and prognostic utility of cfDNA in trauma and sepsis (2019) (46)
Core Outcomes in Ventilation Trials (COVenT): protocol for a core outcome set using a Delphi survey with a nested randomised trial and observational cohort study (2015) (45)
The PIRO Concept: R is for response (2003) (45)
Sepsis Subclasses: A Framework for Development and Interpretation. (2021) (45)
Investigator-led clinical research consortia: The Canadian Critical Care Trials Group (2009) (44)
Progress on core outcome sets for critical care research (2015) (44)
The PIRO (predisposition, insult, response, organ dysfunction) model (2013) (43)
Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure (2016) (43)
Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial—PROSPECT: a pilot trial (2016) (43)
Principles of source control in the management of sepsis. (2011) (42)
Contemporary strategies to improve clinical trial design for critical care research: insights from the First Critical Care Clinical Trialists Workshop (2020) (42)
Sepsis: current status, future prospects (2004) (42)
Continuing challenges of sepsis research. (2001) (42)
Six subphenotypes in septic shock: Latent class analysis of the PROWESS Shock study (2018) (42)
DNR directives are established early in mechanically ventilated intensive care unit patients (2004) (42)
Blood Pressure Targets For Vasopressor Therapy: A Systematic Review (2015) (41)
The Effect of Inadequate Initial Empiric Antimicrobial Treatment on Mortality in Critically Ill Patients with Bloodstream Infections: A Multi-Centre Retrospective Cohort Study (2016) (40)
DAILY VARIATION IN ENDOTOXIN LEVELS IS ASSOCIATED WITH INCREASED ORGAN FAILURE IN CRITICALLY ILL PATIENTS (2007) (40)
Zika virus-induced neurological critical illness in Latin America: Severe Guillain-Barre Syndrome and encephalitis (2017) (39)
Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis (2018) (39)
Surfactant therapy for COVID-19 related ARDS: a retrospective case–control pilot study (2021) (39)
The occurrence and impact of bacterial organisms complicating critical care illness associated with 2009 influenza A(H1N1) infection. (2013) (39)
Misinformation During the Coronavirus Disease 2019 Outbreak: How Knowledge Emerges From Noise (2020) (39)
Early observational research and registries during the 2009–2010 influenza A pandemic (2010) (39)
Organ dysfunction as an outcome measure in clinical trials. (1999) (38)
Women in Intensive Care study: a preliminary assessment of international data on female representation in the ICU physician workforce, leadership and academic positions (2018) (38)
The role of the Src family of tyrosine kinases after oxidant-induced lung injury in vivo. (2004) (38)
Core Outcomes Set for Trials in People With Coronavirus Disease 2019 (2020) (37)
Diethylmaleate attenuates endotoxin-induced lung injury. (1996) (37)
Principles of source control in the management of sepsis. (2009) (37)
Complexity, chaos, and incomprehensibility: parsing the biology of critical illness. (2000) (37)
Critical Illness in Patients With COVID-19: Mounting an Effective Clinical and Research Response. (2020) (36)
Advancing precision medicine for acute respiratory distress syndrome (2021) (36)
Surgical decision-making: integrating evidence, inference, and experience. (2006) (36)
Low-Dose Corticosteroid Treatment in Septic Shock: A Propensity-Matching Study* (2014) (35)
How to use an article on therapy or prevention: pneumonia prevention using subglottic secretion drainage. (1997) (35)
Duration of Antimicrobial Treatment for Bacteremia in Canadian Critically Ill Patients* (2016) (34)
7 versus 14 days of antibiotic treatment for critically ill patients with bloodstream infection: a pilot randomized clinical trial (2018) (33)
The Maternal Syndrome of Preeclampsia: A forme fruste of the Systemic Inflammatory Response Syndrome (2000) (33)
Multiple Organ Dysfunction Syndrome (MODS) (1995) (33)
Transfusion trigger: when to transfuse? (2004) (33)
Efficacy and safety of mesenchymal stromal cells in preclinical models of acute lung injury: a systematic review protocol (2014) (32)
Endotoxemia Following Multiple Trauma: Risk Factors and Prognostic Implications* (2016) (32)
The gut as a potential trigger of exercise-induced inflammatory responses (1998) (31)
Patient and Organizational Factors Associated With Delays in Antimicrobial Therapy for Septic Shock* (2016) (31)
Immunomodulation by altered gastrointestinal tract flora. The effects of orally administered, killed Staphylococcus epidermidis, Candida, and Pseudomonas on systemic immune responses. (1988) (31)
37th International Symposium on Intensive Care and Emergency Medicine (part 2 of 3) (2017) (30)
Development of a Zebrafish Sepsis Model for High-Throughput Drug Discovery (2017) (30)
Evaluating the use of recombinant human activated protein C in adult severe sepsis: Results of the Surviving Sepsis Campaign* (2012) (30)
Discordance between perception and treatment practices associated with intensive care unit-acquired bacteriuria and funguria: A Canadian physician survey* (2008) (30)
Talactoferrin in Severe Sepsis: Results From the Phase II/III Oral tAlactoferrin in Severe sepsIS Trial (2015) (30)
Protective function of DJ-1/PARK7 in lipopolysaccharide and ventilator-induced acute lung injury (2020) (30)
Sepsis defi nitions: time for change (2013) (29)
Global outbreak research: harmony not hegemony (2020) (28)
Intestinal epithelial cells down-regulate macrophage tumor necrosis factor-alpha secretion: a mechanism for immune homeostasis in the gut-associated lymphoid tissue. (1995) (28)
The plasma peptides of ovarian cancer (2018) (28)
Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness. (2019) (28)
Immune Response in the Critically Ill (2002) (28)
Corticosteroid therapy for critically ill patients with COVID-19: A structured summary of a study protocol for a prospective meta-analysis of randomized trials (2020) (27)
Charting the course of critical illness: prognostication and outcome description in the intensive care unit. (1999) (27)
Monocyte Adhesion and Transmigration Induce Tissue Factor Expression: Role of the Mitogen-Activated Protein Kinases (2002) (27)
Clinician discomfort with life support plans for mechanically ventilated patients (2004) (27)
Integrin engagement induces monocyte procoagulant activity and tumor necrosis factor production via induction of tyrosine phosphorylation. (1996) (27)
Pre-B Cell Colony-Enhancing Factor (PBEF/Nampt/Visfatin) Primes Neutrophils for Augmented Respiratory Burst Activity through Partial Assembly of the NADPH Oxidase (2011) (27)
Oxidant-induced priming of the macrophage involves activation of p38 mitogen-activated protein kinase through an Src-dependent pathway. (2003) (26)
New Translational Research Provides Insights into Liver Dysfunction in Sepsis (2012) (26)
A Scoring System for Multiple Organ Dysfunction Syndrome (1994) (26)
Let the Cells Speak: Neutrophils as Biologic Markers of the Inflammatory Response (1998) (26)
Human torture: description and sequelae of 104 cases. (1984) (26)
Upregulated PD-L1 delays human neutrophil apoptosis and promotes lung injury in an experimental animal model of sepsis. (2021) (26)
Intracellular and Extracellular Lipopolysaccharide Signaling in Sepsis: Avenues for Novel Therapeutic Strategies (2021) (26)
Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): study protocol for a pilot randomized controlled trial (2015) (26)
Essential Emergency and Critical Care: a consensus among global clinical experts (2021) (26)
The effect of albumin or crystalloid resuscitation on bacterial translocation and endotoxin absorption following experimental burn injury. (1992) (25)
Selective Decontamination of the Digestive Tract in Surgical Patients (1999) (25)
Co-enrollment of critically ill patients into multiple studies: patterns, predictors and consequences (2013) (25)
Validation of diagnostic gene sets to identify critically ill patients with sepsis (2019) (25)
Global Collaboration in Acute Care Clinical Research: Opportunities, Challenges, and Needs (2017) (24)
The staging of sepsis: understanding heterogeneity in treatment efficacy (2005) (24)
Critical illness is an iatrogenic disorder (2010) (23)
Core Outcome Measures for Trials in People With Coronavirus Disease 2019: Respiratory Failure, Multiorgan Failure, Shortness of Breath, and Recovery (2021) (23)
THE GUT IN CRITICAL ILLNESS: EVIDENCE FROM HUMAN STUDIES (1996) (23)
Pre-Clinical Models of Sepsis (1998) (23)
Activated protein C and septic shock: A propensity-matched cohort study* (2012) (23)
Rethinking Sepsis: From Concepts to Syndromes to Diseases (1999) (22)
Up-regulation of functional CXCR4 expression on human lymphocytes in sepsis (2006) (22)
Important issues in the design and reporting of clinical trials in severe sepsis and acute lung injury. (2008) (22)
Prophylaxis of deep venous thrombosis and pulmonary embolism. (1991) (22)
Evaluating probiotics for the prevention of ventilator-associated pneumonia: a randomised placebo-controlled multicentre trial protocol and statistical analysis plan for PROSPECT (2019) (21)
Saturday night fever: finding and controlling the source of sepsis in critical illness. (2002) (21)
Oxidative Stress Increases Surface Toll-Like Receptor 4 Expression in Murine Macrophages Via Ceramide Generation (2015) (21)
Fluid management and deresuscitation practices: A survey of critical care physicians (2020) (21)
The ecology and immunology of the gastrointestinal tract in health and critical illness. (1991) (21)
The importance of airway and lung microbiome in the critically ill (2020) (21)
Sepsis-3: What is the Meaning of a Definition? (2016) (21)
Gastrointestinal dysfunction in the critically ill: can we measure it? (2008) (20)
37th International Symposium on Intensive Care and Emergency Medicine (part 3 of 3) (2017) (20)
THE EFFECTS OF GRANULOCYTE COLONY-STIMULATING FACTOR IN PRECLINICAL MODELS OF INFECTION AND ACUTE INFLAMMATION (2005) (20)
Modulating neutrophil apoptosis. (2007) (20)
Stress ulcer prophylaxis in critical illness: a Canadian survey (2016) (20)
Developing a framework for the ethical design and conduct of pragmatic trials in healthcare: a mixed methods research protocol (2018) (19)
Measuring organ dysfunction in the intensive care unit: why and how? (2005) (19)
Programmed cell death (apoptosis) and the resolution of systemic inflammation. (1997) (19)
The plasma peptidome (2018) (19)
Empiric antimicrobial therapy in critical illness: results of a surgical infection society survey. (2007) (18)
Modeling MODS: what can be learned from animal models of the multiple-organ dysfunction syndrome? (2005) (18)
Fluid Resuscitation with 5% albumin versus Normal Saline in Early Septic Shock: a pilot randomized, controlled trial. (2012) (18)
Intraabdominal infections in infants and children: Descriptions and definitions (2005) (18)
Exudative neutrophils show impaired pH regulation compared with circulating neutrophils. (1996) (17)
Determinants of outcome in patients with a clinical suspicion of ventilator-associated pneumonia. (2008) (17)
A Research Agenda for Precision Medicine in Sepsis and Acute Respiratory Distress Syndrome: An Official American Thoracic Society Research Statement (2021) (17)
18 – What Is a Symptom-Complex? (1982) (17)
Portal endotoxemia stimulates the release of an immunosuppressive factor from alveolar and splenic macrophages. (1993) (16)
The Multiple Organ Dysfunction (MOD) Score (1997) (16)
The PRECISE RCT: evolution of an early septic shock fluid resuscitation trial. (2012) (16)
Association between sepsis survivorship and long-term cardiovascular outcomes in adults: a systematic review and meta-analysis (2021) (16)
Clinical and scientific importance of source control in abdominal infections: summary of a symposium. (1999) (16)
Through a glass darkly: the brave new world of in silico modeling. (2004) (15)
Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial—PROSPECT: protocol for a feasibility randomized pilot trial (2015) (15)
Activated neutrophils induce epithelial cell apoptosis through oxidant-dependent tyrosine dephosphorylation of caspase-8. (2014) (15)
Hypertonic saline resuscitation from hemorrhagic shock does not impair the neutrophil response to intraabdominal infection. (2008) (15)
Statistical analysis plan of PROWESS SHOCK study (2010) (15)
Biomarkers of sepsis (2006) (14)
Surviving sepsis: a guide to the guidelines (2008) (14)
A Core Outcome Set for Research Evaluating Interventions to Prevent and/or Treat Delirium in Critically Ill Adults: An International Consensus Study (Del-COrS) (2021) (14)
The clinical relevance of oliguria in the critically ill patient: analysis of a large observational database (2020) (14)
Feasibility of conservative fluid administration and deresuscitation compared with usual care in critical illness: the Role of Active Deresuscitation After Resuscitation-2 (RADAR-2) randomised clinical trial (2021) (14)
Influence of perceived functional and employment status on cardiopulmonary resuscitation directives. (2003) (14)
Levels of care in the intensive care unit: a research program. (2006) (14)
Sepsis and mediator-directed therapy: rethinking the target populations. Mediator-directed therapy in sepsis: rethinking the target populations. Toronto, Canada, 31 October-1 November 1998. (1999) (14)
Multicountry survey of emergency and critical care medicine physicians’ fluid resuscitation practices for adult patients with early septic shock (2016) (14)
Bridging Lipid Metabolism and Innate Host Defense (2014) (13)
Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19 (2022) (13)
Sepsis Definitions: A Work in Progress. (2018) (13)
The multiple organ dysfunction syndrome (2001) (13)
Adverse effects of delayed antimicrobial treatment and surgical source control in adults with sepsis: results of a planned secondary analysis of a cluster-randomized controlled trial (2022) (13)
Operationalisation of the Randomized Embedded Multifactorial Adaptive Platform for COVID-19 trials in a low and lower-middle income critical care learning health system. (2021) (13)
The plasma peptides of breast versus ovarian cancer (2019) (12)
Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src (2016) (12)
The Multiple Organ Dysfunction Syndrome: Syndrome, Metaphor, and Unsolved Clinical Challenge (2021) (12)
Upregulated PD-L1 delays human neutrophil apoptosis and promotes lung injury in an experimental mouse model of sepsis. (2021) (12)
Determinants of Citation Impact in Large Clinical Trials in Critical Care: The Role of Investigator-Led Clinical Trials Groups* (2015) (12)
Delayed treatment with diethyl maleate prevents E-selectin expression in human endothelial cells. (1999) (12)
Selective decontamination of the digestive tract in critically ill patients (1999) (12)
Bioavailability of oral ciprofloxacin in early postsurgical patients. (1998) (11)
Mesenchymal stromal (stem) cell therapy modulates miR-193b-5p expression to attenuate sepsis-induced acute lung injury (2021) (11)
Permissive hypotension during shock resuscitation: equipoise in all patients? (2017) (11)
Ethical considerations in conducting surgical research in severe complicated intra-abdominal sepsis (2019) (11)
Pathogens and antimicrobial susceptibility profiles in critically ill patients with bloodstream infections: a descriptive study. (2016) (11)
Participation of ICUs in Critical Care Pandemic Research: A Province Wide, Cross-Sectional Survey* (2013) (11)
Altered Inhibitory &kgr;B Alpha Expression in LPS-Stimulated Alveolar Macrophages Following Resuscitated Hemorrhagic Shock (2011) (11)
Unblinding plan of PROWESS-SHOCK trial (2011) (11)
Understanding the global burden of pediatric sepsis. (2015) (11)
The Measurement of Organ Dysfunction/Failure as an ICU Outcome (1997) (11)
Immunologic Dyshomeostasis in Multiple Organ Failure: The Gut-Liver Axis (1993) (10)
Probiotics in Critical Illness: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (2022) (10)
Economic evaluation of the prophylaxis for thromboembolism in critical care trial (E-PROTECT): study protocol for a randomized controlled trial (2014) (10)
Nosocomial infection in the surgical intensive care unit. (1992) (10)
Mast cell modulation of macrophage procoagulant activity and TNF production. (1995) (10)
Epidemiological and Clinical Characterization of Superinfections in Critically Ill Coronavirus Disease 2019 Patients (2021) (10)
Antioxidants increase lipopolysaccharide-stimulated TNFα release in murine macrophages: Role for altered TNFα mRNA stability (2001) (10)
Extracorporeal shock-wave lithotripsy in the management of bile duct stones. (1988) (10)
The plasma peptides of sepsis (2020) (10)
Risk factors for and prediction of mortality in critically ill medical–surgical patients receiving heparin thromboprophylaxis (2016) (10)
The Richmond Agitation-Sedation Scale Should Not Be Used to Evaluate Neurologic Function. (2016) (10)
Fluid strategies and outcomes in patients with acute respiratory distress syndrome, systemic inflammatory response syndrome and sepsis: a protocol for a systematic review and meta-analysis (2015) (10)
Clinical Markers of Gastrointestinal Dysfunction (1996) (9)
Reporting of Outcomes and Outcome Measures in Studies of Interventions to Prevent and/or Treat Delirium in the Critically Ill: A Systematic Review. (2020) (9)
S100A8/A9 and sRAGE kinetic after polytrauma; an explorative observational study (2017) (9)
Perioperative cardiovascular system failure in South Asians undergoing cardiopulmonary bypass is associated with prolonged inflammation and increased Toll-like receptor signaling in inflammatory monocytes. (2014) (9)
Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness. (2020) (8)
In defense of evidence: the continuing saga of selective decontamination of the digestive tract. (2002) (8)
Controversies in sepsis clinical trials: proceedings of a meeting of the International Sepsis Forum, Lausanne, Switzerland, September 29, 2001. (2006) (8)
Pre-B cell colony enhancing factor induces Nampt-dependent translocation of the insulin receptor out of lipid microdomains in A549 lung epithelial cells. (2015) (8)
Sepsis research: where have we gone wrong? (2006) (8)
Regulation of apoptosis and priming of neutrophil oxidative burst by diisopropyl fluorophosphate (2010) (8)
The End of “One Size Fits All” Sepsis Therapies: Toward an Individualized Approach (2022) (8)
International Survey to Establish Prioritized Outcomes for Trials in People With Coronavirus Disease 2019 (2020) (8)
Activated Protein C and Septic Shock: A Propensity-Matched Cohort Study, (2011) (8)
Multinational, observational study of procalcitonin in ICU patients with presumed or confirmed pneumonia and requiring mechanical ventilation (2006) (8)
Interleukin-1beta mediates LPS-induced inhibition of apoptosis in retinoic acid-differentiated HL-60 cells. (2008) (8)
Marker or mediator? Changes in endotoxin activity as a predictor of adverse outcomes in critical illness (2005) (7)
What we learned from the first World Sepsis Day. (2012) (7)
A Canadian Critical Care Trials Group project in collaboration with the international forum for acute care trialists - Collaborative H1N1 Adjuvant Treatment pilot trial (CHAT): study protocol and design of a randomized controlled trial (2011) (7)
The Global Sepsis Alliance: building new collaborations to confront an under-recognized threat. (2011) (7)
Identifying clinical subtypes in sepsis-survivors with different one-year outcomes: a secondary latent class analysis of the FROG-ICU cohort (2022) (7)
A review of the discharge preparation and initial community support given to families of neonates after surgical intensive care. (1987) (7)
Apoptosis in the Resolution of Systemic Inflammation (1997) (7)
Mesenchymal Stem/Stromal Cells Increase Cardiac miR-187-3p Expression in a Polymicrobial Animal Model of Sepsis (2020) (7)
Circulating Ligands of the Receptor for Advanced Glycation End Products and the Soluble Form of the Receptor Modulate Cardiovascular Cell Apoptosis in Diabetes (2020) (7)
Multiple Organ Failure and Infection: Cause, Consequence, or Coincidence (1992) (7)
Data Driven Analysis Reveals Shared Transcriptome Response, Immune Cell Composition, and Distinct Mortality Rates Across Differing Etiologies of Critical Illness (2020) (7)
The effect of the immunomodulator RU 41,740 (biostim) on the specific and nonspecific immunosuppression induced by thermal injury or protein deprivation. (1988) (7)
Development of an intensive care unit resource assessment survey for the care of critically ill patients in resource‐limited settings (2017) (7)
Sepsis definitions – Authors'reply (2013) (6)
The uncovering of ESE-1 in human neutrophils: implication of its role in neutrophil function and survival (2015) (6)
Kinetics of Serological Responses in Critically Ill Patients Hospitalized With 2009 Pandemic Influenza A(H1N1) Virus Infection in Canada, 2009–2011 (2018) (6)
From Celsus to Galen to Bone: The Illnesses, Syndromes, and Diseases of Acute Inflammation (2001) (6)
Stakeholder perspectives on adaptive clinical trials: a scoping review (2020) (6)
Re-evaluating the Inhibition of Stress Erosions (REVISE): a protocol for pilot randomized controlled trial (2016) (6)
From the bedside back to the bench: the role of preclinical studies in understanding clinical therapies. (2010) (6)
Blood Transfusion Is A Risk Factor For Icu-acquired Infection And The Multiple Organ Dysfunction Syndrome (mods) (1993) (6)
Vasoactive agents and the gut: fueling the motor of multiple organ failure. (2000) (6)
Association of Hydroxyethyl Starch Administration With Mortality and Acute Kidney Injury in Critically Ill Patients Requiring Volume Resuscitation: A Systematic Review and Meta-Analysis (2013) (6)
Systematic Review of Outcome Measures in Randomized Trials of Mediator-Directed Therapies in Sepsis (1997) (6)
Oxidant stress inhibits pH regulatory mechanisms in murine peritoneal macrophages. (1994) (6)
Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology (2021) (6)
Pandemic-Related Submissions: The Challenge of Discerning Signal Amidst Noise. (2020) (5)
Empiric Antibiotics in Critical Illness: Do they Help or Harm? (2003) (5)
Study protocol for a multicentre, prospective cohort study of the association of angiotensin II type 1 receptor blockers on outcomes of coronavirus infection (2020) (5)
Molecular Diagnosis of Coronavirus Disease 2019 (2020) (5)
BAROTRAUMA IN SEVERE ARDS IS GREATEST IN NON DEPENDENT LUNG ZONES; EVALUATION BY COMPUTED TOMOGRAPHY (1993) (5)
Leveraging Transcriptomics to Disentangle Sepsis Heterogeneity. (2017) (5)
ICU-Acquired Infection: Mortality, Morbidity, and Costs (2005) (5)
Distinctive Roles and Mechanisms of Human Neutrophil Peptides in Experimental Sepsis and Acute Respiratory Distress Syndrome (2018) (5)
FLUID trial: a protocol for a hospital-wide open-label cluster crossover pragmatic comparative effectiveness randomised pilot trial (2018) (5)
Use of an impervious wound edge protector decreased postoperative wound infection (2000) (5)
Safety of cell therapy with mesenchymal stromal cells): An updated systematic review and meta-analysis of randomized controlled trials (SafeCell update) (2018) (5)
The International Sepsis Forum's controversies in sepsis: how will sepsis be treated in 2051? (2002) (5)
Infection and the Host Septic Response: Implications for Clinical Trials of Mediator Antagonism (1994) (5)
Antioxidants increase lipopolysaccharide-stimulated TNF alpha release in murine macrophages: role for altered TNF alpha mRNA stability. (2001) (5)
The Effects of Granulocyte Colony-Stimulating Factor (G-CSF) in Pre-Clinical Models of Infection and Acute Inflammation (2005) (5)
An intensivist's dilemma: support of the splanchnic circulation in critical illness. (1998) (5)
CARING FOR THE CRITICALLY ILL PATIENT Association of Hydroxyethyl Starch Administration With Mortality and Acute Kidney Injury in Critically Ill Patients Requiring Volume Resuscitation (2013) (5)
The liver in sepsis: shedding light on the cellular basis of hepatocyte dysfunction (2013) (5)
Clinical expert round table discussion (session 4) at the Margaux Conference on Critical Illness: sepsis: inflammation disorder, coagulation disorder, or both? A challenge for clinicians. (2001) (5)
Enteral feeding in acute pancreatitis: just do it. (2001) (5)
Toll-Like Receptors, Associated Biochemical Signaling Networks, and S100 Ligands. (2020) (5)
Thromboprophylaxis after colorectal surgery - results of a randomized, double-blind comparison of low dose heparin and enoxaparin (1997) (4)
Critical care trainees' career goals and needs: A Canadian survey. (2014) (4)
Effect of age of transfused red blood cells on neurologic outcome following traumatic brain injury (ABLE-tbi Study): a nested study of the Age of Blood Evaluation (ABLE) trial (2019) (4)
A core outcome set for studies evaluating interventions to prevent and/or treat delirium for adults requiring an acute care hospital admission: an international key stakeholder informed consensus study (2021) (4)
Infliximab or Cyclosporine as Rescue Therapy in Patients With Severe Ulcerative Colitis Refractory to Steroids: A Systematic Review and Meta-Analysis: 1772 (2014) (4)
Epithelium-specific Ets transcription factor-1 acts as a negative regulator of cyclooxygenase-2 in human rheumatoid arthritis synovial fibroblasts (2016) (4)
Towards a universal understanding of post COVID-19 condition (2021) (4)
Biomarkers in critical illness: good answers, but what is the question? (2012) (4)
Measurements in the intensive care unit: what do they mean? (2003) (4)
Inflammation Following Lipopolysaccharide Chemoattractant in the Lung: Role in Pulmonary Expression of Cytokine-Induced Neutrophil Hemorrhagic Shock Primes for Increased (1998) (4)
Diagnostic Utility of Different Blood Components in Gene Expression Analysis of Sepsis (2016) (4)
Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis (2018) (4)
Antibiotics for ventilator‐associated pneumonia (2003) (4)
CAGS and ACS evidence based reviews in surgery. 35: Efficacy and safety of low-dose hydrocortisone therapy in the treatment of septic shock. (2010) (4)
Secondary Bacterial Peritonitis (2002) (4)
2009–2010 Influenza A(H1N1)-related critical illness among Aboriginal and non-Aboriginal Canadians (2017) (4)
Research in the Intensive Care Unit (1998) (4)
Role of Active Deresuscitation After Resuscitation-2 (RADAR-2) - a pilot randomised controlled trial of conservative fluid administration and deresuscitation in critical illness: study protocol (2018) (3)
Reporting of Outcomes and Outcome Measures in Studies of Interventions to Prevent and/or Treat Delirium in the Critically Ill: A Systematic Review. (2020) (3)
Pandemic-Related Submissions: The Challenge of Discerning Signal Amidst Noise (2020) (3)
Intravenous immune globulin in septic shock: a Canadian national survey of critical care medicine and infectious disease specialist physicians (2021) (3)
Erratum to: Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock (2010) (3)
Antimicrobial Therapy for ICU-Acquired Infection: Time for a Reappraisal (1998) (3)
Quantifying Threats to the Feasibility of Clinical Trials in Critically Ill Patients. (2009) (3)
Measuring organ dysfunction (2020) (3)
Gaps and opportunities in sepsis translational research (2022) (3)
Daily use of a lactobacilli probiotic prevented antibiotic-associated diarrhea in hospitalized patients (2008) (3)
Understanding Barriers To Recruitment And Why Patients And Surrogates Consent For Critical Care Research: The Consent Study (A CCCTG Project) (2010) (3)
Glucose, insulin, coagulation: endotoxin as exohormone. (2008) (3)
Modulation of macrophage procoagulant activity by arachidonic acid metabolites. (1992) (3)
Iatrogenesis, inflammation and organ injury: insights from a murine model (2006) (3)
BARRIERS TO INVESTIGATOR-INITIATED ICU RESEARCH: A SURVEY OF THE CANADIAN CRITICAL CARE TRIALS GROUP (CCCTG).: 113-M (2005) (3)
Control of the Source of Sepsis (2002) (2)
National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research (2021) (2)
Risk Factors For Pulmonary Embolism In Medical-Surgical ICU Patients (2012) (2)
Building a European ‘network of networks’ for stroke clinical research – The European Stroke Organisation Trials Alliance (ESOTA) (2019) (2)
Evidence-Based Medicine in the Intensive Care Unit (2005) (2)
A risk index with 14 variables predicted 30-day postoperative pneumonia after major noncardiac surgery. (2002) (2)
Core outcome measures for trials in people with COVID-19: respiratory failure, multiorgan failure, shortness of breath and recovery (2020) (2)
Economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): study protocol (2020) (2)
Biomarkers in sepsis: a systematic review (2015) (2)
LB03 - Cellular immunotherapy for septic shock (CISS): a phase I trial (2017) (2)
Choosing the Best Blood Pressure Target for Vasopressor Therapy. (2020) (2)
P-064 Impact of High Dose Vitamin D3 Supplementation in Treatment of Crohn's Disease in Remission: A Randomized Double-Blind Controlled Study (2016) (2)
Corticosteroid Therapy in Critical Illness: A Changing Paradigm (2000) (2)
Through a Glass Darkly: The Gut in Multiple Organ Failure (1990) (2)
Transfusion Requirements in Critical Care (2017) (2)
The failure of clinical trials in sepsis: Challenges of pre-clinical models (1999) (2)
From premise to principle: the impact of the gut hypothesis on the practice of critical care surgery. (1995) (2)
Measuring Treatment Outcomes in Intensive Care: Mortality, Morbidity, and Organ Dysfunction (2002) (2)
Burden of Illness in ThromboEmbolism in Critical Care (BITEC) study: a multicenter Canadian study (2004) (2)
Costs Of Clinical Research Preparation For The H1N1 Pandemic In Canada: A Single Center, Multi-Site Analysis (2011) (2)
P-119 Transition Experience from Pediatric to Adult IBD Care: Results of a Pilot Study (2013) (2)
Pre-Admission Use Of Selective Serotonin Reuptake Inhibitors Is Associated With ICU Mortality (2012) (2)
The pathogenesis and molecular biology of sepsis. (2006) (2)
Risk Prediction and Outcome Description in Critical Surgical Illness (2001) (2)
Fungal infections should be part of the core outcome set for COVID-19 – Authors' reply (2020) (2)
2009-2010 H1N1-Related Critical Illness Among Aboriginal Canadians And Non-Aboriginal Canadians (2011) (2)
ESICM LIVES 2016: part one (2016) (2)
The Maternal Syndrome of Preeclampsia: A forme (2000) (2)
Organ dysfunction and death in patients admitted to hospital with COVID-19 in pandemic waves 1 to 3 in British Columbia, Ontario and Quebec, Canada: a cohort study (2022) (2)
Long-Term Patient Outcomes After Prolonged Mechanical Ventilation: The Towards RECOVER Study (2011) (1)
The changing face of critical care: Task force on tropical diseases. (2017) (1)
a Debate On The Subject “are Sirs And Mods Important In The Clinical Evaluation Of Patients?” (2000) (1)
Transfusion in the intensive care unit. (2005) (1)
Proteinase-Activated Receptor-1 Mediates Elastase-Induced Apoptosis of Human Lung (2005) (1)
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study (2022) (1)
The use of intensive insulin therapy and pentastarch resuscitation in patients with severe sepsis (2009) (1)
Three Decades of Collaboration in Critical Care Research. (2020) (1)
An antibiotic regimen for 8 days was as effective as one for 15 days in ventilator-associated pneumonia. (2004) (1)
SIRS, MODS, and the Brave New World of ICU Acronyms: Have They Helped Us? (2000) (1)
Comprar Critical Care Emergency Medicine | David Farcy | 9780071628242 | Mcgraw-Hill Interamericana (2011) (1)
Outcome Measures for Clinical Trials in Sepsis: Introduction (1997) (1)
Human Genome Project (1997) (1)
Surgical approaches to the management of acute severe necrotizing pancreatitis (1999) (1)
The Neutrophil in the Pathogenesis of Multiple Organ Dysfunction Syndrome (2007) (1)
Impact Of MRSA Pneumonia In Patients Outcome (2010) (1)
The Web in the management of biomarkers of sepsis (2009) (1)
Haemoglobin transfusion threshold in traumatic brain injury optimisation (HEMOTION): a multicentre, randomised, clinical trial protocol (2022) (1)
Determination of Prognosis During Neurointensive Care in Children and Adults with Traumatic Brain Injury: An Update (2012) (1)
Neutrophil Apoptosis is Accelerated Following Phagocytosis of Candida albicans: 21 (2000) (1)
Insights Into a "Negative" ICU Trial Derived From Gene Expression Profiling. (2019) (1)
Defining the Biologic Objectives of Mediator-Directed Therapy: Overview (1997) (1)
Validation and Comparison of Algorithms to Identify Adult‐Onset Inflammatory Bowel Disease Patients From Within Health Administrative Data: P‐40 YI (2012) (1)
The Role of Endotoxin in Septic Shock-Reply. (2019) (1)
MONARCS: Statistical or Clinical Meaning? (2005) (1)
The Effects of Granulocyte Colony-Stimulating Factor (G-CSF) in Pre-Clinical Models of Infection and Acute Inflammation (1998) (1)
Mortality As a Measure of Treatment Effect in Clinical Trials Recruiting Critically Ill Patients* (2023) (1)
The failure of clinical trials in sepsis: Challenges of clinical trial design (1999) (1)
DELAYED NEUTROPHIL (PMN) APOPTOSIS IS ASSOCIATED WITH INCREASED MITOCHONDRIAL MEMBRANE POTENTIAL AND PRESERVATION OF CYTOCHROME C IN EXPERIMENTAL AND CLINICAL SEPSIS. (1999) (1)
SAFETY OF TARGETED ANTIBIOTIC THERAPY FOR VENTILATOR ASSOCIATED PNEUMONIA (VAP).: 373 (2006) (1)
Programmed Cell Death (Apoptosis) and the Immunologic Derangements of Critical Illness (2002) (1)
Review Transfusion trigger: when to transfuse? (2004) (1)
Chapter 78 – Acute Pancreatitis (2008) (1)
DNA and sRAGE circulation in the early phase after polytrauma (2015) (1)
LB07 – Serial assessment of systemic levels of proinflammatory cytokines in septic shock patients treated with allogeneic mesenchymal stem cells (2017) (1)
P-171 Exploring Needs During Transition from Adolescence to Adulthood in Young Adults with Inflammatory Bowel Disease: A Qualitative Study (2013) (1)
The Gut-Liver Axis in Multiple Organ Failure (1992) (1)
Antibiodic Resistance in the Intensive Care Unit (2006) (1)
Chapter 55 – Sepsis (2006) (1)
Contemporary variations on the ancient theme of the gut in critical illness (1998) (1)
Prevalent And Incident Bacterial Infections Among Canadian Critically Ill Patients With Influenza A (H1N1) 2009- Preliminary Data (2011) (1)
Clinical trials in surgical infection (2017) (1)
Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial. (2023) (1)
A Comparison Of The First And Second Waves Of H1N1-Related Critical Illness In Canada (2011) (1)
CARDIOPULMONARY RESUSCITATION (CPR) IS AN EXTRAORDINARY INTERVENTION IN A NON CARDIAC ADULT INTENSIVE CARE UNIT. (1995) (1)
Correction to: Ethical considerations in conducting surgical research in severe complicated intra-abdominal sepsis (2019) (1)
Risk Prediction, Disease Stratification, and Outcome Description in Critical Surgical Illness (2008) (1)
Predictors of clinician discomfort with daily life support plans for mechanically ventilated patients (2003) (1)
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Multiple Organ Dysfunction (MOD) Score (1998) (0)
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The effect of inadequate initial antimicrobial treatment on mortality in critically ill patients with bloodstream infections (2015) (0)
Response to Letter to the Editor (Mangioni et al). (2019) (0)
In Memoriam: Roger C. Bone, M.D. (1997) (0)
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Oxygen Delivery and Utilization: A Mathematical Artifact or a Target for Personalized Medicine? (2020) (0)
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QUESTION: In patients having abdominal surgery, does the use of an impervious wound edge protector reduce postoperative wound infections? (2000) (0)
ANTIBIOTICS FOR VENTILATOR-ASSOCIATED PNEUMONIA(VAP): A SYSTEMATIC REVIEW: 477 (2002) (0)
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Funding Source And Publication Impact Of Large Randomized Controlled Trials In Critical Care (2011) (0)
Outcomes of Second‐ and Third‐LineTumor Necrosis Factor‐Î± Antagonists in Inflammatory Bowel Disease: 985 (2016) (0)
Clinical Trials of Mediator-Targeted Therapy in Sepsis (2000) (0)
Endotoxaemia in Critical Illness: Rapid Detection and Clinical Relevance (1999) (0)
Determinants of Citation impaCt for Large CLin- iCaL triaLs in CritiCaL Care (2013) (0)
Roundtable II: clinical implications of anticoagulation mediator replacement in sepsis and acute respiratory distress syndrome. (2000) (0)
Sepsis: Our Second Year (1998) (0)
Cost-effectivenessofDalteparinvsUnfractionatedHeparin forthePreventionofVenousThromboembolism inCriticallyIllPatients (2014) (0)
Efficacy and safety of mesenchymal stromal cell therapy in preclinical animal models of sepsis (2015) (0)
The authors reply. (2022) (0)
Surfactant Therapy for COVID-19 Related ARDS: A Retrospective Case-Control Pilot Study. (2020) (0)
THE PRESSURE-ADJUSTED RATE (PAR): A SIMPLE AND VALID DESCRIPTOR OF THE CARDIOVASCULAR DYSFUNCTION OF MODS (1998) (0)
Quanti fi cation of Cystic Fibrosis Using Computed Tomography (2015) (0)
Prevention of acute lung injury using a sulfhydryl agent (2005) (0)
Canadian ENHANCE data support the efficacy and safety of drotrecogin alfa (activated) despite higher disease severity than the global ENHANCE population (2005) (0)
Surgical Infection Society Presidential Address Perspectives in Surgical Infections : What Does the Future Hold ? (2010) (0)
THE TWO‐HIT HYPOTHESIS: INFECTION AND ENDOTOXEMIA: 684 (1997) (0)
THE MULTIPLE ORGAN DYSFUNCTION (MOD) SCORE: 685 (1997) (0)
697: INFLUENCE OF ANTIBIOTIC DOSE ADJUSTMENT ON MORTALITY IN CONTINUOUS RENAL REPLACEMENT THERAPY (2016) (0)
Evidence-Based Medicine in ICU (2011) (0)
Commentary Surviving sepsis: a guide to the guidelines (2008) (0)
Not with a Bang But a Whimper: Apoptosis in the Pathogenesis of Systemic Inflammation (1998) (0)
A185 Infrared thermal imaging of the hand during vascular occlusion in healthy volunteers (2016) (0)
42 THE LIVER AS AH IMMUNOLOGIC ORGAN IN TRAUMA AND SEPSIS (1995) (0)
Hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages: A novel mechanism of cell priming for LPS signaling (2005) (0)
R is for response (2003) (0)
Enrolling Critically Ill Patients Into Multiple Studies: A Case Study Of A Thromboprophylaxis Trial (2012) (0)
Nasogastric and nasojejunal feeding did not differ for acute-phase response or pain in severe acute pancreatitis. (2005) (0)
Multiple Organ Failure and the Gastrointestinal Tract: New Perspectives on an Old Hypothesis (2018) (0)
Reporting of mesenchymal stromal cell (MSC) manufacturing and characterization in a systematic review of MSC treatment for pre-clinical models of sepsis (2015) (0)
Intravenous Fluids in Septic Shock - More or Less? (2022) (0)
Pyrrolidine dithiocarbamate (PDTC) increases TNF-α mRNA stability (1996) (0)
Interdisciplinary, prompt access IBD clinic: The hamilton health science experience: O-15. (2011) (0)
Chapter 48 – Pancreatitis (2006) (0)
Establishing Healthcare Worker Performance and Safety in Providing Critical Care for Patients in a Simulated Ebola Treatment Unit: Non-Randomized Pilot Study (2021) (0)
Oxidant-induced TLR4 translocation in murine macrophages is Src kinase dependent (2007) (0)
Steroids Redux: Targeting the Mineralocorticoid Axis in Sepsis. (2017) (0)
Critical care surgery: past or future tense? (2006) (0)
Case Presentation: Dr. Daniel deBacker, Free University of Brussels (2000) (0)
Apoptosis in Critical Illness: A Primer for the Intensivist (2008) (0)
Quantifying Challenges for the Conduct of Pilot Randomized Controlled Trials of Critically Ill Patients. (2009) (0)
Identification of group v phospholipase A2 (GV PLA2) in human neutrophils (PMN): role in E. coli phospholipid hydrolysis (2000) (0)
Targeting Signals Lipid Rafts, Detergent-Resistant Membranes, and Raft (2015) (0)
Differential effect of decontamination of the digestive tract (SDD) on mortality in the surgical and medical ICU (2005) (0)
APOPTOSIS IN THE LUNG IN TRAUMA AND SEPSIS: 212 (2004) (0)
PROPOFOL INDUCES APOPTOSIS IN HUMAN NEUTROPHILS IN-VITRO: A POTENTIAL WAY TO ATTENUATE THE OVERWHELMING POST-TRAUMATIC INFLAMMATORY RESPONSE (2005) (0)
Systemic plus topical antibiotic prophylaxis reduced acquired infections and organ dysfunction in critically ill adults. (2003) (0)
Location, location, location--unraveling the nuances of innate immune regulation*. (2012) (0)
ACTIVATED NEUTROPHILS DEMONSTRATE THIOL‐DEPENDENT RESISTANCE TO FAS TRIGGERED APOPTOTIC SIGNALS: 464 (1997) (0)
Predisposition to Sepsis (2008) (0)
100 Prolonged cardiovascular system failure in South Asians undergoing cardiopulmonary bypass correlates with prolonged inflammation and increased TLR4-mediated signaling (2011) (0)
A guide to the guide to the guidelines: Staying afloat in turbulent seas (2008) (0)
TARGETING THERAPY TO THE APPROPRIATE POPULATION: 686 (1997) (0)
504: PHENOBARBITAL VERSUS BENZODIAZEPINES IN THE TREATMENT OF ALCOHOL WITHDRAWAL SYNDROME (2016) (0)
The authors reply. (2022) (0)
Withdrawal of ventilatory support in the intensive care unit (2003) (0)
Characteristics of the Study Group at Admission to the ICU According to the Quartiles of Fluid Balance at 24 Hours (0)
Microbial Translocation: from Myth to Mechanism (2002) (0)
The most compelling lesson of September 11. (2002) (0)
MONARCS : Statistical or clinical meaning? Authors' reply (2005) (0)
The PRECISE Fluid Resuscitation Pilot Randomized Controlled Trial: Study Design And Preliminary Feasibility Results (2010) (0)
660: Determinants of Citation Impact for Large Clinical Trials in Critical Care (2013) (0)
Health economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): a cost-effectiveness analysis (2022) (0)
The Immunomodulatory Effects of Anesthetic and Analgesic Agents (2002) (0)
Selective digestive decontamination in critically ill patients. (1995) (0)
Editorial: Sepsis-Rites of Passage (1997) (0)
Systematic Review And Meta-Analysis Of Mesenchymal Stromal Cells In Pre-Clinical Models Of Septic Shock (2012) (0)
Abstract 11527: Prolonged Cardiovascular System Failure in South Asians Undergoing Cardiopulmonary Bypass Correlates with Prolonged Inflammation and Increased TLR4-Mediated Signaling (2011) (0)
InjuryExpression in Endotoxin-Induced Acute Lung Thiol-Mediated Regulation of ICAM-1 (1998) (0)
The PROWESS SHOCK trial: reply to Paramesh et al. (2009) (0)
Antiembolic stockings and pneumatic compression devices in a medical-surgical thromboprophylaxis trial (2011) (0)
Iatrogenesis in the intensive care unit: The interface between complex patients and simple technologies (2011) (0)
Contesting Conversion: Genealogy, Circumcision, and Identity in Ancient Judaism and Christianity. By Matthew Thiessen. (2013) (0)
Light and Shadow: Perspectives on Host-Microbial Interactions in the Pathogenesis of Intensive Care Unit-Acquired Infection (2001) (0)
The authors reply. (2016) (0)
Commentary Measurements in the intensive care unit: what do they mean? (2003) (0)
THE TIME COURSE OF MEDIATOR PRODUCTION IN GRAM POSITIVE INFECTION: 263 (2004) (0)
Systematic review of industry-led versus investigator-led randomized controlled trials (2011) (0)
Hemorrhagic Shock Modulates Toll-Like Receptor-4 (TLR4) Expression in Response to LPS: 19 (2000) (0)
Consequences of suspected heparin-induced thrombocytopenia in the ICU (2012) (0)

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