John D. Hayes
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Engineering Computer Science
John D. Hayes's Degrees
- PhD Computer Science Stanford University
- Masters Electrical Engineering University of California, Berkeley
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(Suggest an Edit or Addition)John D. Hayes's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. (1995) (3565)
- Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. (1999) (1474)
- The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. (2014) (1439)
- Glutathione S‐transferases (2002) (1396)
- Glutathione transferases. (2005) (1287)
- p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription* (2010) (1131)
- Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression* (2003) (1012)
- Glutathione S-Transferase Polymorphisms and Their Biological Consequences (2000) (950)
- NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. (2009) (776)
- The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. (2001) (667)
- Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases (2019) (633)
- Nomenclature for human glutathione transferases. (1992) (633)
- SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner (2011) (592)
- Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease. (2015) (591)
- Oxidative Stress in Cancer. (2020) (566)
- Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway. (2010) (488)
- Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity. (2012) (487)
- Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. (2001) (476)
- Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence. (2003) (471)
- Dimerization of Substrate Adaptors Can Facilitate Cullin-mediated Ubiquitylation of Proteins by a “Tethering” Mechanism (2006) (458)
- Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice. (2002) (402)
- Potential contribution of the glutathione S-transferase supergene family to resistance to oxidative stress. (1995) (382)
- The cancer chemopreventive actions of phytochemicals derived from glucosinolates (2008) (374)
- Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals (2010) (369)
- Redox-regulated Turnover of Nrf2 Is Determined by at Least Two Separate Protein Domains, the Redox-sensitive Neh2 Degron and the Redox-insensitive Neh6 Degron* (2004) (363)
- Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors. (2004) (358)
- The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin. (2000) (332)
- Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention. (2001) (330)
- Nomenclature for mammalian soluble glutathione transferases. (2005) (296)
- Glutathione S-transferases: biomedical applications. (1993) (290)
- Nrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent Genes* (2008) (288)
- Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis (2012) (285)
- Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds. (2009) (269)
- Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of nrf2 by cancer chemotherapeutic agents. (2006) (264)
- Glutathione S-transferase mu locus: use of genotyping and phenotyping assays to assess association with lung cancer susceptibility. (1991) (263)
- Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha (2007) (257)
- Glutathione S-transferase and glutathione peroxidase expression in normal and tumour human tissues. (1990) (245)
- RXRα inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2. (2013) (235)
- Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis. (2010) (234)
- Glutathione and glutathione-dependent enzymes in ovarian adenocarcinoma cell lines derived from a patient before and after the onset of drug resistance: intrinsic differences and cell cycle effects. (1988) (218)
- Nrf2, a guardian of healthspan and gatekeeper of species longevity. (2010) (206)
- Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome. (2005) (206)
- Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates. (2004) (204)
- Molecular mechanisms of drug resistance. (1990) (199)
- Expression and polymorphism of glutathione S-transferase in human lungs: risk factors in smoking-related lung cancer. (1995) (192)
- Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. (1999) (192)
- Activation of hepatic Nrf2 in vivo by acetaminophen in CD‐1 mice (2004) (185)
- Induction of phase I and phase II drug-metabolizing enzyme mRNA, protein, and activity by BHA, ethoxyquin, and oltipraz. (1995) (182)
- Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents (2011) (177)
- Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Response, and Disturbance in the Expression of Metabolic Enzymes but Not with Insulin Resistance (2014) (177)
- The gasotransmitter hydrogen sulfide induces nrf2-target genes by inactivating the keap1 ubiquitin ligase substrate adaptor through formation of a disulfide bond between cys-226 and cys-613. (2013) (172)
- Immunohistochemical localization of glutathione S-transferases in human lung. (1993) (170)
- Polymorphism in cytochrome P450 CYP2D6, CYP1A1, CYP2E1 and glutathione S-transferase, GSTM1, GSTM3, GSTT1 and susceptibility to tobacco-related cancers: studies in upper aerodigestive tract cancers. (1998) (169)
- Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents. (2009) (160)
- Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver. (2000) (151)
- Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver (2010) (150)
- Reduction in antioxidant defenses may contribute to ochratoxin A toxicity and carcinogenicity. (2006) (142)
- The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic. (2015) (140)
- Polymorphism at the glutathione S-transferase locus GSTM3: interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma. (1996) (140)
- Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2 (2015) (139)
- Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning (2010) (136)
- Contribution of the glutathione S-transferases to the mechanisms of resistance to aflatoxin B1. (1991) (131)
- The hepatotoxic metabolite of acetaminophen directly activates the Keap1‐Nrf2 cell defense system (2008) (130)
- Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2) (2017) (130)
- Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H‐1,2‐dithiole‐3‐thione (2008) (129)
- Amplification and increased expression of alpha class glutathione S-transferase-encoding genes associated with resistance to nitrogen mustards. (1988) (128)
- Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum. (2006) (126)
- The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer. (2006) (123)
- Distribution of glutathione S-transferase isoenzymes in human kidney: basis for possible markers of renal injury. (1989) (122)
- Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3. (2015) (122)
- Use of immuno-blot techniques to discriminate between the glutathione S-transferase Yf, Yk, Ya, Yn/Yb and Yc subunits and to study their distribution in extrahepatic tissues. Evidence for three immunochemically distinct groups of transferase in the rat. (1986) (121)
- Reduced levels of drug-induced DNA cross-linking in nitrogen mustard-resistant Chinese hamster ovary cells expressing elevated glutathione S-transferase activity. (1987) (121)
- Antioxidant and cytoprotective responses to redox stress. (2004) (120)
- Expression of human glutathione S-transferases in Saccharomyces cerevisiae confers resistance to the anticancer drugs adriamycin and chlorambucil. (1990) (119)
- Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype. (2005) (118)
- Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction. (2012) (117)
- Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases. (2001) (114)
- Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein. (2008) (113)
- Cellular response to cancer chemopreventive agents: contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress. (1999) (112)
- Ethoxyquin-induced resistance to aflatoxin B1 in the rat is associated with the expression of a novel alpha-class glutathione S-transferase subunit, Yc2, which possesses high catalytic activity for aflatoxin B1-8,9-epoxide. (1991) (111)
- Altered bleomycin-induced lung fibrosis in osteopontin-deficient mice. (2004) (110)
- An ethoxyquin-inducible aldehyde reductase from rat liver that metabolizes aflatoxin B1 defines a subfamily of aldo-keto reductases. (1993) (109)
- Expression of glutathione S-transferases and cytochrome P450 in normal and tumor breast tissue. (1990) (103)
- Resistance to aflatoxin B1 is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic aldehyde-containing metabolite of the toxin. (1993) (101)
- Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones. (2010) (93)
- Regulation of rat glutathione S-transferase A5 by cancer chemopreventive agents: mechanisms of inducible resistance to aflatoxin B1. (1998) (92)
- The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation. (2007) (90)
- Molecular cloning and heterologous expression of a cDNA encoding a mouse glutathione S-transferase Yc subunit possessing high catalytic activity for aflatoxin B1-8,9-epoxide. (1992) (90)
- Increased bioactivation of dihaloalkanes in rat liver due to induction of class theta glutathione S-transferase T1-1. (1998) (88)
- Cross-talk between transcription factors AhR and Nrf2: lessons for cancer chemoprevention from dioxin. (2009) (88)
- Pulmonary expression of glutathione S-transferase M3 in lung cancer patients: association with GSTM1 polymorphism, smoking, and asbestos exposure. (1995) (85)
- A novel aldehyde reductase with activity towards a metabolite of aflatoxin B1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant. (1993) (83)
- Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms (2011) (83)
- Plasma glutathione S-transferase measurements after paracetamol overdose: evidence for early hepatocellular damage. (1985) (83)
- Glutathione S-transferase isoenzymes and glutathione peroxidase activity in normal and tumour samples from human lung. (1988) (78)
- Conjugation of highly reactive aflatoxin B1 exo-8,9-epoxide catalyzed by rat and human glutathione transferases: estimation of kinetic parameters. (1997) (77)
- Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase. (1998) (75)
- Deficiency of Glutathione Transferase Zeta Causes Oxidative Stress and Activation of Antioxidant Response Pathways (2006) (75)
- Glutathione S-transferases and carcinogenesis (1987) (74)
- Evidence that glutathione S-transferases B1B1 and B2B2 are the products of separate genes and that their expression in human liver is subject to inter-individual variation. Molecular relationships between the B1 and B2 subunits and other Alpha class glutathione S-transferases. (1989) (73)
- The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroquinone but not by endoplasmic reticulum stressors. (2009) (70)
- The Nrf3 Transcription Factor Is a Membrane-bound Glycoprotein Targeted to the Endoplasmic Reticulum through Its N-terminal Homology Box 1 Sequence* (2009) (70)
- Identification of a basic hybrid glutathione S-transferase from human liver. Glutathione S-transferase delta is composed of two distinct subunits (B1 and B2). (1985) (69)
- Identification of two lithocholic acid-binding proteins. Separation of ligandin from glutathione S-transferase B. (1979) (69)
- Cloning of cDNAs from fetal rat liver encoding glutathione S-transferase Yc polypeptides. The Yc2 subunit is expressed in adult rat liver resistant to the hepatocarcinogen aflatoxin B1. (1994) (67)
- Sequence, catalytic properties and expression of chicken glutathione-dependent prostaglandin D2 synthase, a novel class Sigma glutathione S-transferase. (1998) (67)
- Characterization of a human class-Theta glutathione S-transferase with activity towards 1-menaphthyl sulphate. (1992) (66)
- Raised plasma glutathione S-transferase values in hyperthyroidism and in hypothyroid patients receiving thyroxine replacement: evidence for hepatic damage. (1985) (65)
- Transcription Factor Nrf1 Negatively Regulates the Cystine/Glutamate Transporter and Lipid-Metabolizing Enzymes (2014) (64)
- Human microsomal glutathione S-transferase. Its involvement in the conjugation of hexachlorobuta-1,3-diene with glutathione. (1989) (64)
- A partnership with the proteasome; the destructive nature of GSK3 (2018) (64)
- Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy. (2014) (62)
- The major glutathione S-transferase in salmonid fish livers is homologous to the mammalian pi-class GST. (1991) (61)
- Glutathione S-transferase isoenzymes in human tumours and tumour derived cell lines. (1989) (61)
- The effects of selenium and copper deficiencies on glutathione S-transferase and glutathione peroxidase in rat liver. (1987) (61)
- Enhanced expression of glutathione S-transferases in colorectal carcinoma compared to non-neoplastic mucosa. (1991) (59)
- Expression of the aflatoxin B1-8,9-epoxide-metabolizing murine glutathione S-transferase A3 subunit is regulated by the Nrf2 transcription factor through an antioxidant response element. (2003) (59)
- Differential induction of class alpha glutathione S-transferases in mouse liver by the anticarcinogenic antioxidant butylated hydroxyanisole. Purification and characterization of glutathione S-transferase Ya1Ya1. (1989) (59)
- Substrate specificity of an aflatoxin-metabolizing aldehyde reductase. (1995) (59)
- Cytosolic and microsomal glutathione S-transferase isoenzymes in normal human liver and intestinal epithelium. (1989) (58)
- Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases. (2001) (58)
- Biochemical and genetic characterization of a murine class Kappa glutathione S-transferase. (2003) (55)
- Transcription Factor Nrf1 Is Topologically Repartitioned across Membranes to Enable Target Gene Transactivation through Its Acidic Glucose-Responsive Domains (2014) (53)
- Elevation of AKR7A2 (succinic semialdehyde reductase) in neurodegenerative disease (2001) (53)
- Sex-specific constitutive expression of the pre-neoplastic marker glutathione S-transferase, YfYf, in mouse liver. (1987) (52)
- Oltipraz-mediated changes in aflatoxin B(1) biotransformation in rat liver: implications for human chemointervention. (1996) (52)
- Allelism at the glutathione S-transferase GSTM3 locus: interactions with GSTM1 and GSTT1 as risk factors for astrocytoma. (1996) (51)
- Plasma Glutathione S-Transferase Measurements and Liver Disease in Man (1987) (50)
- Prostaglandin D2 synthase enzymes and PPARgamma are co-expressed in mouse 3T3-L1 adipocytes and human tissues. (2003) (50)
- Direct comparison of the nature of mouse and human GST T1-1 and the implications on dichloromethane carcinogenicity. (2002) (49)
- Regulation of aflatoxin B1-metabolizing aldehyde reductase and glutathione S-transferase by chemoprotectors. (1994) (48)
- Deduced amino acid sequence, gene structure and chromosomal location of a novel human class Mu glutathione S-transferase, GSTM4. (1993) (48)
- The selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression (2015) (47)
- A study of the structures of the YaYa and YaYc glutathione S-transferases from rat liver cytosol. Evidence that the Ya monomer is responsible for lithocholate-binding activity. (1981) (47)
- Identification of topological determinants in the N-terminal domain of transcription factor Nrf1 that control its orientation in the endoplasmic reticulum membrane. (2010) (47)
- Over‐expression of P‐glycoprotein and glutathione S‐transferase PI in MCF‐7 cells selected for vincristine resistance in vitro (1992) (46)
- Nrf2 orchestrates fuel partitioning for cell proliferation. (2012) (46)
- Glutathione S-transferases in human liver cancer. (1991) (46)
- The polymorphic expression of neutral glutathione S-transferase in human mononuclear leucocytes as measured by specific radioimmunoassay. (1987) (46)
- Purification and characterization of glutathione S-transferases P, S and N. Isolation from rat liver of Yb1 Yn protein, the existence of which was predicted by subunit hybridization in vitro. (1984) (46)
- Purification of human hepatic glutathione S-transferases and the development of a radioimmunoassay for their measurement in plasma. (1983) (45)
- Human Mu-class glutathione S-transferases present in liver, skeletal muscle and testicular tissue. (1993) (44)
- A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways. (2013) (44)
- Development of specific radioimmunoassays for the measurement of human hepatic basic and N/A2b glutathione S-transferases. (1984) (44)
- Immunolocalization of microsomal glutathione S-transferase in rat tissues. (1997) (44)
- Variations in the glutathione S-transferase subunits expressed in human livers. (1986) (42)
- Characterization of the basic glutathione S-transferase B1 and B2 subunits from human liver. (1987) (42)
- Tissue-specific Expression and Subcellular Distribution of Murine Glutathione S-transferase Class Kappa (2004) (42)
- Inhibition of hepatic and extrahepatic glutathione S-transferases by primary and secondary bile acids. (1986) (42)
- Anomalous electrophoretic behaviour of the glutathione S-transferase Ya and Yk subunits isolated from man and rodents. A potential pitfall for nomenclature. (1986) (41)
- The cap'n'collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics. (2011) (41)
- Selective elution of rodent glutathione S-transferases and glyoxalase I from the S-hexyglutathione-Sepharose affinity matrix. (1988) (41)
- Expression of the murine glutathione S-transferase alpha3 (GSTA3) subunit is markedly induced during adipocyte differentiation: activation of the GSTA3 gene promoter by the pro-adipogenic eicosanoid 15-deoxy-Delta12,14-prostaglandin J2. (2003) (40)
- Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter. (2003) (40)
- Regulation of mouse glutathione S-transferases by chemoprotectors. Molecular evidence for the existence of three distinct alpha-class glutathione S-transferase subunits, Ya1, Ya2, and Ya3, in mouse liver. (1991) (40)
- GLUTATHIONE S-TRANSFERASE POLYMORPHISM AND THEIR BIOLOGICAL CONSEQUENCE (2000) (40)
- Protection conferred by selenium deficiency against aflatoxin B1 in the rat is associated with the hepatic expression of an aldo-keto reductase and a glutathione S-transferase subunit that metabolize the mycotoxin. (1997) (40)
- Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins. (2002) (39)
- Glutathione S-transferase isoenzymes in human renal carcinoma demonstrated by immunohistochemistry. (1989) (39)
- Targeted Overexpression of Galanin in Lactotrophs of Transgenic Mice Induces Hyperprolactinemia and Pituitary Hyperplasia1. (1999) (39)
- Characterization of the rat glutathione S-transferase Yc2 subunit gene, GSTA5: identification of a putative antioxidant-responsive element in the 5'-flanking region of rat GSTA5 that may mediate chemoprotection against aflatoxin B1. (1996) (38)
- Glutathione-s-transferase pi expression in leukaemia: a comparative analysis with mdr-1 data. (1990) (38)
- Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics. (2012) (38)
- The membrane-topogenic vectorial behaviour of Nrf1 controls its post-translational modification and transactivation activity (2013) (38)
- Cholic acid binding by glutathione S-transferases from rat liver cytosol. (1980) (37)
- Positive and negative regulation of prostaglandin E2 biosynthesis in human colorectal carcinoma cells by cancer chemopreventive agents. (2003) (36)
- Blotting techniques for the study of DNA, RNA, and proteins. (1989) (35)
- Purification and physical characterization of glutathione S-transferase K. Differential use of S-hexylglutathione and glutathione affinity matrices to isolate a novel glutathione S-transferase from rat liver. (1986) (35)
- 1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha,beta-unsaturated aldehyde acrolein. (2009) (35)
- Bile acid inhibition of basic and neutral glutathione S-transferases in rat liver. (1983) (35)
- Rat liver glutathione S-transferases. A study of the structure of the basic YbYb-containing enzymes. (1983) (34)
- Regulation of carbonyl-reducing enzymes in rat liver by chemoprotectors. (1996) (34)
- Glutathione S-transferases in alcoholic liver disease. (1990) (33)
- Variation in the expression of Mu-class glutathione S-transferase isoenzymes from human skeletal muscle. Evidence for the existence of heterodimers. (1991) (32)
- Purification from rat liver of a novel constitutively expressed member of the aldo-keto reductase 7 family that is widely distributed in extrahepatic tissues. (2000) (32)
- Glutathione S-transferase levels in autoimmune chronic active hepatitis: a more sensitive index of hepatocellular damage than aspartate transaminase. (1988) (32)
- Glutathione S-transferases in man: the relationship between rat and human enzymes. (1987) (31)
- Regulation of glutathione S-transferases and aldehyde reductase by chemoprotectors: studies of mechanisms responsible for inducible resistance to aflatoxin B1. (1996) (30)
- Purification and characterization of three forms of glutathione S-transferase A. A comparative study of the major YaYa-, YbYb- and YcYc-containing glutathione S-transferases. (1982) (30)
- Measurements of glutathione S-transferase B1 in plasma after birth asphyxia: an early indication of hepatocellular damage. (1989) (29)
- Glutathione S-transferases and drug resistance (1990) (29)
- Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes (2014) (29)
- NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis (2020) (29)
- Fish and mammalian liver cytosolic glutathione S-transferases: Substrate specificities and immunological comparison (1989) (28)
- Nrf2-Mediated Neuroprotection Against Recurrent Hypoglycemia Is Insufficient to Prevent Cognitive Impairment in a Rodent Model of Type 1 Diabetes (2016) (27)
- Plasma glutathione S-transferase measurements by radioimmunoassay: a sensitive index of hepatocellular damage in man. (1985) (27)
- Expression of glyoxalase, glutathione peroxidase and glutathione S-transferase isoenzymes in different bovine tissues. (1989) (26)
- Partial purification of two lithocholic acid-binding proteins from rat liver 100 000g supernatants. (1977) (25)
- Purification of acidic glutathione S-transferases from human lung, placenta and erythrocyte and the development of a specific radioimmunoassay for their measurement. (1988) (24)
- Impaired hepatocellular integrity during general anaesthesia, as assessed by measurement of plasma glutathione S-transferase. (1986) (23)
- A physiologically-based pharmacokinetic(PB-PK) model for ethylene dibromide: relevance of extrahepatic metabolism. (2000) (23)
- Targeted overexpression of galanin in lactotrophs of transgenic mice induces hyperprolactinemia and pituitary hyperplasia. (1999) (22)
- Characterization of liver injury, oval cell proliferation and cholangiocarcinogenesis in glutathione S-transferase A3 knockout mice (2017) (22)
- Growth hormone- and testosterone-dependent regulation of glutathione transferase subunit A5 in rat liver. (1998) (21)
- Modulation of glutathione S-transferases and glutathione peroxidase by the anticarcinogen butylated hydroxyanisole in murine extrahepatic organs. (1992) (21)
- Induction and suppression of glutathione transferases by interferon in the mouse. (1987) (20)
- Glutathione S-transferase in human bile. (1989) (19)
- Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions. (2017) (19)
- Zinc‐binding triggers a conformational‐switch in the cullin‐3 substrate adaptor protein KEAP1 that controls transcription factor NRF2 (2018) (19)
- Hepatic glutathione S-transferases in mice fed on a diet containing the anticarcinogenic antioxidant butylated hydroxyanisole. Isolation of mouse glutathione S-transferase heterodimers by gradient elution of the glutathione-Sepharose affinity matrix. (1991) (19)
- Glutathione S-transferase isoenzymes in human bronchoal veolar lavage: a possible early marker for the detection of lung cancer (1990) (18)
- Increased levels of alpha-class and pi-class glutathione S-transferases in cell lines resistant to 1-chloro-2,4-dinitrobenzene. (1993) (18)
- Preferential over-expression of the class alpha rat Ya2 glutathione S-transferase subunit in livers bearing aflatoxin-induced pre-neoplastic nodules. Comparison of the primary structures of Ya1 and Ya2 with cloned class alpha glutathione S-transferase cDNA sequences. (1990) (18)
- Expression of an abundant alpha-class glutathione S-transferase in bovine and human adrenal cortex tissues. (1992) (17)
- Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival. (2017) (17)
- Plasma glutathione S-transferase measurements in patients with alcoholic cirrhosis. (1987) (17)
- Alteration of glutathione S-transferase levels in Barrett's metaplasia compared to normal oesophageal epithelium (2003) (17)
- Nrf 2-mediated neuroprotection against recurrent hypoglycemia is insufficient to prevent cognitive impairment in a rodent model of type 1 diabetes Running title : Nrf 2 and cognitive impairment in T 1 D (2016) (16)
- Induction of the Antioxidant Response by the Transcription Factor NRF2 Increases Bioactivation of the Mutagenic Air Pollutant 3-Nitrobenzanthrone in Human Lung Cells. (2019) (15)
- Regulation of the CNC-bZIP transcription factor Nrf2 by Keap1 and the axis between GSK-3 and β-TrCP (2016) (15)
- A comparison of the subcellular distribution, subunit composition and bile acid-binding activity of glutathione S-transferases from trout and rat liver (1981) (15)
- Localisation of α, μ and π class glutatione S-transferases in kidney: comparison with CuZn superoxide dismutase (1993) (15)
- Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress (2021) (14)
- INVITED COMMENTARY POTENTIAL CONTRIBUTION OF THE FAMILY TO RESISTANCE TO OXIDATIVE STRESS GLUTATHIONE S-TRANSFERASE SUPERGENE (1995) (14)
- Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase. (2010) (14)
- Lecithin: cholesterol acyltransferase in Down's syndrome. (1983) (14)
- Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants (2015) (14)
- Decreased hepatic glutathione S-transferase A, AA and L concentration produced by prolonged thyroid hormone administration. (1988) (14)
- Metabolic competence and susceptibility of intestinal epithelium to genotoxic injury during regeneration. (1997) (14)
- Modulation of the cytochrome P450 system as a mechanism of chemoprotection. (1996) (13)
- Glutathione S-transferase subunits in the mouse and their catalytic activities towards reactive electrophiles. (1987) (13)
- Age-dependent change of metabolic capacity and genotoxic injury in rat intestine. (1998) (13)
- Determinants of specificity for aflatoxin B1-8,9-epoxide in alpha-class glutathione S-transferases. (1999) (12)
- Glutathione S-transferase localization in aflatoxin B1-treated rat livers. (1990) (11)
- Nonalcoholic steatohepatitis and mechanisms by which it is ameliorated by activation of the CNC-bZIP transcription factor Nrf2. (2022) (11)
- Expression of rat aldehyde reductase AKR7A1: influence of age and sex and tissue-specific inducibility. (2002) (10)
- Expression and Localization of Rat Aldo-Keto Reductases and Induction of the 1B13 and 1D2 Isoforms by Phenolic Antioxidants (2010) (10)
- Hepatic damage in the rat following administration of thyroxine or triiodothyronine, assessed by measurement of plasma glutathione S-transferase YaYa concentrations. (1986) (9)
- Cytotoxicity of xenobiotics and expression of glutathione-S-transferases in immortalised rat hepatocyte cell lines (1998) (9)
- Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer (2016) (8)
- Glutathione S-transferase mu locus (1991) (8)
- 3‐(2‐Oxoethylidene)indolin‐2‐one Derivatives Activate Nrf2 and Inhibit NF‐κB: Potential Candidates for Chemoprevention (2014) (8)
- Radioimmunoassay Measurements of the Human Glutathione S-Transferases (1990) (7)
- Spatial monitoring of toxicity in HMOX-LacZ transgenic mice (2010) (7)
- The primary and secondary metabolism of aflatoxin B1 by rat hepatocytes cultured on matrigel. (1994) (7)
- Lines Confer Protection against DNA Damage in Human Colon Cell Cruciferous Vegetables Can Both Stimulate Apoptosis and Dietary Indoles and Isothiocyanates That Are Generated from Updated (2001) (7)
- Effect of nicardipine infusion on the release of glutathione S-transferase following halothane anaesthesia. (1989) (7)
- Purification of bile acid-binding proteins from rat hepatic cytosol. Use of a photoaffinity label to detect novel Y' binders. (1986) (6)
- Localisation of alpha, mu and pi class glutathione S-transferases in kidney: comparison with CuZn superoxide dismutase. (1993) (6)
- Peroxiredoxin gene expression signatures in liver reflect toxic insult. (2010) (6)
- New insights into nuclear factor erythroid 2-related factors in toxicology and pharmacology. (2019) (5)
- Back Cover: 3-(2-Oxoethylidene)indolin-2-one Derivatives Activate Nrf2 and Inhibit NF-κB: Potential Candidates for Chemoprevention (ChemMedChem 8/2014) (2014) (5)
- Cytosolic andmicrosomal glutathione S-transferase isoenzymes innormal humanliver andintestinal epithelium (1989) (4)
- Glutathione S-transferase isoenzymes in human bronchoalveolar lavage: a possible early marker for the detection of lung cancer. (1990) (4)
- Electrophoresis of proteins and nucleic acids: II--Techniques and applications. (1989) (4)
- Growth hormone-and testosterone-dependent regulation of glutathione transferase subunit A 5 in rat liver (1998) (4)
- Aflatoxin aldehyde reductases (2002) (3)
- Mammalian Glutathione S-Transferase Genes: Structure and Regulation (2006) (3)
- Determinants of specificity for aflatoxin B-8,9-epoxide in Alpha-class glutathione S-transferases (1999) (3)
- An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver (2022) (3)
- Electrophoresis of proteins and nucleic acids: I--Theory. (1989) (3)
- Molecular genetics of drug resistence (1997) (3)
- University of Dundee The selective post-translational processing of transcription factor Nrf 1 yields distinct isoforms that dictate its ability to differentially regulate gene expression (2015) (2)
- Nrf2-mediated induction of antioxidant response element-driven gene expression by flavonoids is dependent on their chemical structure (2011) (1)
- Competing Reactions of Aflatoxin B1Dialdehyde: Enzymatic Reduction versus Adduction with Lysine (2003) (1)
- An ethoxyquin-inducible aldehyde reductase from rat liver that metabolizes aflatoxin B 1 defines a subfamily of aldo-keto reductases ( chemprotection / liver cancer / antioiddant ) (2005) (1)
- Anticarcinogenic effects of glucosinolate breakdown products. (2007) (1)
- RESEARCH COMMUNICATION A novel aldehyde reductase with activity towards a metabolite of aflatoxin B. is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant (1993) (1)
- Bioactive components in foods. (2007) (1)
- Corrigendum to “An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver” [Redox Biol. 55 (2022) 102396/PMID: 35839629] (2022) (1)
- Mycoplasma-mediated bone resorption in bone organ cultures. (1995) (1)
- High-fat diet-fed nuclear factor-erythroid 2-related factor 2-null mice demonstrate increased susceptibility to non-alcoholic steatohepatitis without peripheral insulin resistance. (2011) (0)
- The study of DNA, RNA and proteins using blotting techniques (1991) (0)
- is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of (2015) (0)
- Glutathione S-transferases inhumanliver cancer (1991) (0)
- University of Dundee Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf 2 ( NF-E 2 p 45-Related Factor 2 ) (2018) (0)
- Mechanisms by which fruit phytochemicals act as cancer chemopreventive agents (2009) (0)
- University of Dundee Nrf2-mediated neuroprotection response to recurrent hypoglycemia is insufficient to prevent cognitive impairment in a rodent model of type 1 diabetes McNeilly, (2016) (0)
- by Selenium Deficiency against Aflatoxin in the Rat Is Associated with the Hepatic Expression of an Aldo-Keto Reductase and a Glutathione S-Transferase Subunit That Metabolize the Mycotoxin' (2006) (0)
- Erratum to 'Expression of rat aldehyde reductase AKR7A1: influence of age and sex and tissue-specific inducibility' [Biochemical Pharmacology V.62 (2001) 1511-1519] (2002) (0)
- Alteration of phase II drug detoxifying enzyme levels in Barrett's metaplasia compared to normal oesophageal epithelium (2001) (0)
- Anticarcinogenic effects of glucosinalate breakdown products (2007) (0)
- Enhancing the enzymatic defences: Antioxidant response element linked gene expression in animals (2007) (0)
- Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/ (cid:1) -TrCP Axis (2012) (0)
- Nrf2, aGuardianof Healthspan andGatekeeper of Species Longevity (0)
- The Nrf2-Keap1 pathway: a gatekeeper against oxidative and electrophile stress (2010) (0)
- Chemotherapeutic Agents Redox-Dependent Activation of Nrf 2 by Cancer Driven Reporter Gene Cell Line and Its Use to Show − Generation of a Stable Antioxidant Response Element (2006) (0)
- Design, synthesis and biological evaluation of peptide inhibitors of the Keap1-Nrf2 protein-protein interaction (2011) (0)
- PL-17 - Redox-dependent and independent regulation of GSH metabolism and GST family of genes (2016) (0)
- Cholic AcidBinding byGlutathione S-Transferases fromRatLiver Cytosol (1980) (0)
- Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases (2019) (0)
- Protective effects of cafestol and Kahweol against aflatoxin B1 toxicity (1996) (0)
- Oxidative stress and the Nrf1 and Nrf2 transcription factors (2007) (0)
- A mechanistic approach to fruit phytochemicals and cancer (2009) (0)
- Molecular and cellular control of the membrane-bound Nrf1 transcription factor (2009) (0)
- Cut-price knockout? (1995) (0)
- Resistance to Aflatoxin Bj Is Associated with the Expression of a Novel Aldo-Keto Reductase Which Has Catalytic Activity towards a Cytotoxic Aldehyde-containing Metabolite of the Toxin1 (2006) (0)
- Regulation of Nrf2 by redox and other cellular signalling pathways, and its influence on xenobiotic and lipid metabolism (2017) (0)
- Dimerisation of adaptor protein Keap1 is required to correctly position Nrf2 for ubiquitylation upon the Cul3‐Rbx1 holoenzyme: the ‘fixed‐ends’ model (2007) (0)
- INDUCIBLE EXPRESSION OF ANTOXIDANT AND DETOXICATION ENZYMES AS A MECHANISM OF CANCER CHEMOPREVENTION (2000) (0)
- Microsoft Word-77595686-file00 (2009) (0)
- Abstract 828: Design, synthesis and biological evaluation of peptide inhibitors of the Keap1-Nrf2 protein-protein interaction (2011) (0)
- Astrocytic Nrf2 is a mediator of ischemic preconditioning (2011) (0)
- Nrf2,aGuardianof HealthspanandGatekeeperofSpeciesLongevity (2010) (0)
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What Schools Are Affiliated With John D. Hayes?
John D. Hayes is affiliated with the following schools:
