John D. Schuetz
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Molecular Biology
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Biology
John D. Schuetz's Degrees
- PhD Molecular Biology University of California, Berkeley
- Masters Biochemistry Stanford University
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(Suggest an Edit or Addition)John D. Schuetz's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype (2001) (2338)
- Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression (2001) (2153)
- Identification of functionally variant MDR1 alleles among European Americans and African Americans (2001) (1037)
- The Stem Cell Marker Bcrp/ABCG2 Enhances Hypoxic Cell Survival through Interactions with Heme* (2004) (666)
- MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs (1999) (573)
- Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes. (1992) (561)
- Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo (2002) (529)
- Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. (1996) (524)
- Mrp4 Confers Resistance to Topotecan and Protects the Brain from Chemotherapy (2004) (416)
- Disrupted Bile Acid Homeostasis Reveals an Unexpected Interaction among Nuclear Hormone Receptors, Transporters, and Cytochrome P450* (2001) (392)
- Role of ABCG2/BCRP in biology and medicine. (2006) (364)
- Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration (2012) (353)
- High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter. (2004) (344)
- Identification of a mammalian mitochondrial porphyrin transporter (2006) (343)
- Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3. (2001) (340)
- Imatinib Mesylate Is a Potent Inhibitor of the ABCG2 (BCRP) Transporter and Reverses Resistance to Topotecan and SN-38 in Vitro (2004) (321)
- Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). (2003) (305)
- A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase. (1995) (303)
- Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver. (1994) (292)
- Functional Involvement of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) in the Renal Elimination of the Antiviral Drugs Adefovir and Tenofovir (2007) (286)
- Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine. (2003) (281)
- P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans. (1996) (274)
- Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms. (1995) (262)
- Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms. (1996) (255)
- Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice. (2003) (254)
- 17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1A1: a comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA. (1992) (245)
- Mutant p53 Cooperates with ETS and Selectively Up-regulates Human MDR1 Not MRP1* (2001) (242)
- The role of transporters in cellular heme and porphyrin homeostasis. (2007) (231)
- Interactions between Hepatic Mrp4 and Sult2a as Revealed by the Constitutive Androstane Receptor and Mrp4 Knockout Mice* (2004) (231)
- 6′,7′‐Dihydroxybergamottin in grapefruit juice and Seville orange juice: Effects on cyclosporine disposition, enterocyte CYP3A4, and P‐glycoprotein (1999) (228)
- Gefitinib Enhances the Antitumor Activity and Oral Bioavailability of Irinotecan in Mice (2004) (202)
- Regulation of human liver cytochromes P‐450 in family 3A in primary and continuous culture of human hepatocytes (1993) (201)
- Spatiotemporal Coupling of cAMP Transporter to CFTR Chloride Channel Function in the Gut Epithelia (2007) (200)
- The MYND Motif Is Required for Repression of Basal Transcription from the Multidrug Resistance 1 Promoter by the t(8;21) Fusion Protein (1998) (196)
- Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate. (1996) (193)
- Variability in human cytochrome P450 paclitaxel metabolism. (1995) (193)
- Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates. (2002) (192)
- Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells. (2002) (190)
- Use of human hepatocytes to study P450 gene induction. (1996) (188)
- Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction. (2013) (179)
- Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat. (2004) (179)
- p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents. (1997) (175)
- Plasma Membrane Localization of Multidrug Resistance-Associated Protein Homologs in Brain Capillary Endothelial Cells (2004) (173)
- Mrp4−/− mice have an impaired cytoprotective response in obstructive cholestasis (2006) (172)
- Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element. (1998) (172)
- Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. (2002) (165)
- O-demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4. (1994) (164)
- Expression of cytochrome P450 3A in amphibian, rat, and human kidney. (1992) (157)
- Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo. (2006) (156)
- Interaction of Cytochrome P450 3A Inhibitors with P-Glycoprotein (2002) (145)
- Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12. (2001) (140)
- Transporter-mediated protection against thiopurine-induced hematopoietic toxicity. (2008) (139)
- Multiple Human Isoforms of Drug Transporters Contribute to the Hepatic and Renal Transport of Olmesartan, a Selective Antagonist of the Angiotensin II AT1-Receptor (2007) (138)
- Limited Brain Distribution of [3R,4R,5S]-4-Acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate Phosphate (Ro 64-0802), a Pharmacologically Active Form of Oseltamivir, by Active Efflux across the Blood-Brain Barrier Mediated by Organic Anion Transporter 3 (Oat3/Slc22a8) and Multidrug Res (2009) (127)
- CHARACTERIZATION OF TRANSPORT PROTEIN EXPRESSION IN MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN (MRP) 2-DEFICIENT RATS (2006) (126)
- Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta. (1993) (122)
- Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdr1 genes. (2000) (121)
- 5-Fluorouracil incorporation into DNA of CF-1 mouse bone marrow cells as a possible mechanism of toxicity. (1984) (121)
- Expression of MRP4 Confers Resistance to Ganciclovir and Compromises Bystander Cell Killing* (2002) (115)
- Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution. (2007) (115)
- Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein. (2000) (114)
- Reduced folate carrier expression in acute lymphoblastic leukemia: a mechanism for ploidy but not lineage differences in methotrexate accumulation. (1999) (113)
- Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells. (1996) (112)
- Multidrug resistance-associated protein 4 is involved in the urinary excretion of hydrochlorothiazide and furosemide. (2007) (110)
- Regulation of cytochrome P-450b/e and P-450p gene expression by growth hormone in adult rat hepatocytes cultured on a reconstituted basement membrane. (1990) (110)
- ABC transporters and their role in nucleoside and nucleotide drug resistance. (2012) (106)
- Human MDR1 and mouse mdr1a P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid or benzo(a)pyrene. (1998) (102)
- Differences in folylpolyglutamate synthetase and dihydrofolate reductase expression in human B-lineage versus T-lineage leukemic lymphoblasts: mechanisms for lineage differences in methotrexate polyglutamylation and cytotoxicity. (1997) (99)
- Involvement of Multiple Efflux Transporters in Hepatic Disposition of Fexofenadine (2008) (99)
- The ABC Transporter Abcg2/Bcrp: Role in Hypoxia Mediated Survival (2005) (95)
- Function-dependent Conformational Changes of the ABCG2 Multidrug Transporter Modify Its Interaction with a Monoclonal Antibody on the Cell Surface* (2005) (94)
- IDH1 and IDH2 mutations in pediatric acute leukemia (2011) (93)
- The Arachidonic Acid Metabolome Serves as a Conserved Regulator of Cholesterol Metabolism (2014) (84)
- Role of MRP4 and MRP5 in biology and chemotherapy (2008) (83)
- Cyclic nucleotide compartmentalization: contributions of phosphodiesterases and ATP-binding cassette transporters. (2013) (81)
- Involvement of MRP4 (ABCC4) in the Luminal Efflux of Ceftizoxime and Cefazolin in the Kidney (2007) (80)
- Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes. (1992) (79)
- Induction of cytochrome P4503A by taxol in primary cultures of human hepatocytes. (1998) (78)
- Evidence for a functional defect in the translocation of the methotrexate transport carrier in a methotrexate-resistant murine L1210 leukemia cell line. (1988) (77)
- Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver. (1989) (77)
- Nonsense mediated decay downregulates conserved alternatively spliced ABCC4 transcripts bearing nonsense codons. (2003) (76)
- Extracellular matrix regulation of multidrug resistance in primary monolayer cultures of adult rat hepatocytes. (1993) (71)
- cGMP transport by vesicles from human and mouse erythrocytes (2007) (71)
- A common polymorphism in the bile acid receptor farnesoid X receptor is associated with decreased hepatic target gene expression. (2007) (68)
- Prostaglandin signaling regulates ciliogenesis by modulating intraflagellar transport (2014) (67)
- Sp1 and Egr-1 Have Opposing Effects on the Regulation of the RatPgp2/mdr1b Gene* (1999) (63)
- Therapeutic and biological importance of getting nucleotides out of cells: a case for the ABC transporters, MRP4 and 5. (2002) (61)
- Increasing Systemic Exposure of Methotrexate by Active Efflux Mediated by Multidrug Resistance-Associated Protein 3 (Mrp3/Abcc3) (2008) (61)
- ATP-dependent Mitochondrial Porphyrin Importer ABCB6 Protects against Phenylhydrazine Toxicity* (2012) (61)
- Induction of Mdr1b expression by tumor necrosis factor‐α in rat liver cells is independent of p53 but requires NF‐κB signaling (2001) (58)
- Abcb11 Deficiency Induces Cholestasis Coupled to Impaired β-Fatty Acid Oxidation in Mice* (2012) (58)
- Obstacles to Brain Tumor Therapy: Key ABC Transporters (2017) (56)
- The role of ABCG2 and ABCB6 in porphyrin metabolism and cell survival. (2011) (55)
- A method for the synchronization of cultured cells with aphidicolin: application to the large-scale synchronization of L1210 cells and the study of the cell cycle regulation of thymidylate synthase and dihydrofolate reductase. (1989) (54)
- Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance. (2003) (53)
- Development of a real-time in vivo transcription assay: application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents. (2002) (52)
- Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice. (2015) (52)
- Cell survival under stress is enhanced by a mitochondrial ATP-binding cassette transporter that regulates hemoproteins. (2009) (51)
- Evaluation of the Role of Breast Cancer Resistance Protein (BCRP/ABCG2) and Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) in The Urinary Excretion of Sulfate and Glucuronide Metabolites of Edaravone (MCI-186; 3-Methyl-1-phenyl-2-pyrazolin-5-one) (2007) (51)
- Promoter and Intronic Sequences of the Human Thiopurine S-Methyltransferase (TPMT) Gene Isolated from a Human Pacl Genomic Library (1997) (49)
- Heterogeneity of cytochrome P450IIIA expression in rat gut epithelia (1992) (48)
- Phenotypic variability in induction of p‐glycoprotein mrna by aromatic hydrocarbons in primary human hepatocytes (1995) (47)
- Heterogeneity of cytochrome P450IIIA expression in rat gut epithelia. (1992) (42)
- Divergent regulation of the class II P-glycoprotein gene in primary cultures of hepatocytes versus H35 hepatoma by glucocorticoids. (1995) (42)
- Renal and hepatic family 3A cytochromes P450 (CYP3A) in spontaneously hypertensive rats. (1995) (40)
- Deregulated Hepatic Metabolism Exacerbates Impaired Testosterone Production in Mrp4-deficient Mice* (2012) (40)
- Induction of Mdr1b expression by tumor necrosis factor-alpha in rat liver cells is independent of p53 but requires NF-kappaB signaling. (2001) (39)
- The ABCC4 membrane transporter modulates platelet aggregation. (2015) (39)
- Contribution of Abcc4-Mediated Gastric Transport to the Absorption and Efficacy of Dasatinib (2013) (39)
- Creation of Polarized Cells Coexpressing CYP3A4, NADPH Cytochrome P450 Reductase and MDR1/P-glycoprotein (2004) (38)
- Multi-drug Resistance Protein 4 (MRP4)-mediated Regulation of Fibroblast Cell Migration Reflects a Dichotomous Role of Intracellular Cyclic Nucleotides* (2012) (37)
- Conserved Intramolecular Disulfide Bond Is Critical to Trafficking and Fate of ATP-binding Cassette (ABC) Transporters ABCB6 and Sulfonylurea Receptor 1 (SUR1)/ABCC8* (2011) (37)
- Human Immunodeficiency Virus Protease Inhibitors Interact with ATP Binding Cassette Transporter 4/Multidrug Resistance Protein 4: A Basis for Unanticipated Enhanced Cytotoxicity (2013) (36)
- Beyond Competitive Inhibition: Regulation of ABC Transporters by Kinases and Protein-Protein Interactions as Potential Mechanisms of Drug-Drug Interactions (2018) (36)
- Deficiency of ATP-Binding Cassette Transporter B6 in Megakaryocyte Progenitors Accelerates Atherosclerosis in Mice (2014) (35)
- The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6 (2016) (34)
- Isolation of rat pgp3 cDNA: evidence for gender and zonal regulation of expression in the liver. (1994) (34)
- Dihydrofluorouracil, a fluorouracil catabolite with antitumor activity in murine and human cells. (1985) (34)
- ABCB6, an ABC Transporter Impacting Drug Response and Disease (2017) (34)
- Impaired 2',3'-dideoxy-3'-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11. (2002) (34)
- The Role of Transporters in Toxicity and Disease (2014) (33)
- Expression of the Pregnane X Receptor in Mice Antagonizes the Cholic Acid–Mediated Changes in Plasma Lipoprotein Profile (2005) (33)
- Divergent effects of cycloheximide on the induction of class II and class III cytochrome P450 mRNAs in cultures of adult rat hepatocytes. (1990) (33)
- Identification of a new P-glycoprotein-like ATP-binding cassette transporter gene that is overexpressed during hepatocarcinogenesis. (1997) (32)
- Compartmentalized Accumulation of cAMP near Complexes of Multidrug Resistance Protein 4 (MRP4) and Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Contributes to Drug-induced Diarrhea* (2015) (31)
- PharmGKB Update: II. CYP3A5, Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 (2004) (31)
- Alteration of the secondary structure of newly synthesized DNA from murine bone marrow cells by 5-fluorouracil. (1986) (30)
- Maternal bile acid transporter deficiency promotes neonatal demise (2015) (30)
- Tobacco carcinogen NNK transporter MRP2 regulates CFTR function in lung epithelia: implications for lung cancer. (2010) (29)
- Zebrafish abcb11b mutant reveals strategies to restore bile excretion impaired by bile salt export pump deficiency (2018) (29)
- Regulation of gene expression by miR-144/451 during mouse erythropoiesis. (2019) (29)
- Membrane protein changes in an L1210 leukemia cell line with a translocation defect in the methotrexate-tetrahydrofolate cofactor transport carrier. (1989) (29)
- Repression of Human Reduced Folate Carrier Gene Expression by Wild Type p53* (2001) (27)
- Protection against chemotherapy-induced alopecia: targeting ATP-binding cassette transporters in the hair follicle? (2013) (27)
- Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis. (2017) (27)
- ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy. (2015) (26)
- Deoxycytidine kinase modulates the impact of the ABC transporter ABCG2 on clofarabine cytotoxicity. (2011) (26)
- Allopurinol inhibits de novo purine synthesis in lymphoblasts of children with acute lymphoblastic leukemia. (1996) (25)
- Investigation of the Importance of Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4) in the Active Efflux of Anionic Drugs Across the Blood-Brain Barrier. (2017) (23)
- Mdr1b facilitates p53-mediated cell death and p53 is required for Mdr1b upregulation in vivo (2001) (23)
- Bromocriptine Transcriptionally Activates the Multidrug Resistance Gene (pgp2/mdr1b) by a Novel Pathway* (1997) (23)
- The effect of 5-fluorouracil on DNA chain elongation in intact bone marrow cells. (1985) (23)
- A novel role for OATP2A1/SLCO2A1 in a murine model of colon cancer (2017) (23)
- Isolation of a genomic clone containing the promoter region of the human ATP binding cassette (ABC) transporter, ABCB6. (2002) (22)
- The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma (2021) (22)
- ABCG2 requires a single aromatic amino acid to “clamp” substrates and inhibitors into the binding pocket (2020) (22)
- Leukemia and ABC transporters. (2015) (19)
- An unexpected protein interaction promotes drug resistance in leukemia (2017) (18)
- Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumour growth and sensitises to irinotecan in vivo. (2017) (17)
- Induction of P‐Glycorprotein mRNA by protein synthesis inhibition is not controlled by a transcriptional repressor protein in rat and human liver cells (1995) (16)
- Advances in Brief Imatinib Mesylate Is a Potent Inhibitor of the ABCG 2 ( BCRP ) Transporter and Reverses Resistance to Topotecan and SN-38 in Vitro (2004) (14)
- Isolation of CYP3A5P cDNA from human liver: a reflection of a novel cytochrome P-450 pseudogene. (1995) (14)
- Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humans (2006) (14)
- Unimpaired immune functions in the absence of Mrp4 (Abcc4). (2009) (13)
- Transient inhibition of DNA synthesis by 5-fluorodeoxyuridine leads to overexpression of dihydrofolate reductase with increased frequency of methotrexate resistance. (1988) (13)
- Deficiency of ATP binding cassette transporter b6 in megakaryocyte progenitors accelerates atherosclerosis in mice (2014) (12)
- Linker Domains: Why ABC Transporters 'Live in Fragments no Longer'. (2019) (12)
- Identification of rifampin-inducible P 450 IIIA 4 ( CYP 3 A 4 ) in human small bowel enterocytes (2013) (12)
- PKA and actin play critical roles as downstream effectors in MRP4-mediated regulation of fibroblast migration. (2015) (11)
- Influence of Multidrug Resistance-Associated Proteins on the Excretion of the ABCC1 Imaging Probe 6-Bromo-7-[11C]Methylpurine in Mice (2018) (11)
- Crucial Role for Phylogenetically Conserved Cytoplasmic Loop 3 in ABCC4 Protein Expression* (2013) (10)
- Differential effects of thiopurine methyltransferase (TPMT) and multidrug resistance-associated protein gene 4 (MRP4) on mercaptopurine toxicity (2017) (9)
- Forskolin modifies retinal vascular development in Mrp4-knockout mice. (2012) (8)
- Induction of P-glycoprotein mRNA by protein synthesis inhibition is not controlled by a transcriptional repressor protein in rat and human liver cells. (1995) (7)
- The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics (2020) (7)
- Using Pharmacology to Squeeze the Life Out of Childhood Leukemia, and Potential Strategies to Achieve Breakthroughs in Medulloblastoma Treatment (2020) (6)
- An ABC Transporter Drives Medulloblastoma Pathogenesis by Regulating Sonic Hedgehog Signaling (2020) (6)
- The Absence of Mrp4 Has No Effect on the Recruitment of Neutrophils and Eosinophils into the Lung after LPS, Cigarette Smoke or Allergen Challenge (2013) (5)
- Development of A Real-Time in Vivo Transcription Assay : Application Reveals Pregnane X Receptor-Mediated Induction of CYP 3 A 4 by Cancer Chemotherapeutic Agents (2002) (5)
- Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death (2015) (5)
- The effects of prolonged treatment with zidovudine, lamivudine, and abacavir on a T-lymphoblastoid cell line. (2006) (5)
- Influence of ABC transporters on the excretion of ciprofloxacin assessed with PET imaging in mice. (2021) (4)
- Lack of multidrug resistance-associated protein 4 (Mrp4) alters the kinetics of acetaminophen toxicity (2019) (4)
- HIV protease inhibitors interact with ABCC 4 / MRP 4 : a basis for unanticipated enhanced cytotoxicity (2013) (3)
- Multidrug-resistance-associated protein 1 (Mrp1) is probably not required for murine Th cell activation. (2006) (3)
- Heme Interaction with the Pyruvate Dehydrogenase Complex: A Novel Strategy to Promote Hypoxic Survival (2019) (3)
- Mrp4 expression in wildtype and Mrp4 -/- mice (2004) (3)
- Minimal change in transport and growth requirement for folic acid fa in an l1210 leukemia cell line with markedly impaired transport of methotrexate mtx (1988) (3)
- Structural and functional analysis of the human TPMT gene promoter. (1998) (3)
- Development and validation of an LC-MS/MS method to quantify the bromodomain and extra-terminal (BET) inhibitor JQ1 in mouse plasma and brain microdialysate: Application to cerebral microdialysis study. (2021) (3)
- Lack of multidrug-resistance associated protein 4 prolongs partial hepatectomy-induced hepatic steatosis. (2020) (2)
- Multidrug resistance‐associated protein 4 (Mrp4) is a novel genetic factor in the pathogenesis of obesity and diabetes (2021) (2)
- TNF-alpha mediated up-regulation of the multidrug resistance gene mdr1b but not of mrp1 in rat hepatocytes is dependent on NF-kappa B activation (1999) (2)
- Purine Analogue Drug Cytotoxicity and Tissue Distribution Substrate Overlap between Mrp 4 and Abcg 2 / Bcrp Affects (2007) (2)
- Differential effect of allopurinol (hpp) on incorporation of 5-fluorouracil (fu) into rna of tumor and host cells isolated from cf1 mice bearing ehrlich ascites tumor (et). Abstr. (1981) (2)
- DNA repair following incorporation of 5-fluorouracil into DNA of mouse bone marrow cells (1988) (2)
- Metabolic switching in pluripotent stem cells reorganizes energy metabolism and subcellular organelles. (2019) (2)
- Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters (2021) (2)
- 73 Adaptive renal ABC transporter expression in common bile duct-ligated mice (2004) (1)
- The ABC transporter Mrp4/Abcc4 is required for Leydig cell protection from chemotherapeutic drugs (2013) (1)
- ATP-binding Cassette Protein C4 (Abcc4) in the Retina of Zebrafish: Role in Regulating Melanosome Aggregation in the Retinal Pigment Epithelium (2015) (1)
- Crucial role for phylogenetically conserved cytoplasmic loop 3 in ABCC4 protein expression. (2013) (1)
- p53-Mediated Regulation of Expression of a Rabbit Liver Carboxylesterase Confers Sensitivity to 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) (2003) (1)
- 1106 Hepatic and renal ABC transporter expression as critical determinants of ursodeoxycholic acid-induced bile infarcts in bile duct-ligated mice (2003) (1)
- ABC transporters and cancer. Preface. (2015) (1)
- Bone marrow (BM) toxicity secondary to fluoropyrimidine (FP) drugs; Incorporation into RNA as the major determinant of BM toxicity (1982) (1)
- "OMICs" reveal the molecular basis of a rare blood group. (2020) (1)
- Reduced Folate Carrier Expression in Acute Lymphoblastic Leukemia: A Mechanism for Ploidy but not Lineage Differences in Methotrexate Accumulation (1999) (1)
- ABC transporters and cancer (2015) (1)
- Gefitinib (’Iressa’, ZD1839) is a BCRP and MDR1 inhibitor. (2004) (1)
- Biology of Mitochondrial ABCs and Their Contribution to Pathology (2016) (1)
- Preclinical Evaluation of Sorafenib in Combination with Cytarabine and Clofarabine in Acute Myeloid Leukemia (AML). (2007) (1)
- Hypoxic Adaptation by a Unique Mechanism of Reprogramming Mitochondrial Metabolism (2016) (1)
- Venetoclax Synergistically Enhances the Antileukemic Activity of Imipridone ONC213, a Novel Imipridone ONC201 Analog, in Acute Myeloid Leukemia (2018) (1)
- ATP‐dependent efflux transporter ABCC4 is a positive regulator of the Sonic Hedgehog signaling pathway (2019) (0)
- Developing Inhibitors that Exploit ABCG2 and Cancer Dependencies to Improve Therapeutic Outcome (2019) (0)
- Cyclic nucleotide dependent regulation of fibroblast migration by multi drug resistant protein 4 (2013) (0)
- Genetic Basis for Quantitative and Qualitative Changes in Drug Targets (2002) (0)
- ABCC 4 , a plasma membrane transporter modulating platelet aggregation (2015) (0)
- A Single Amino Acid in ABCG2 is Essential for Clamping Substrates and Inhibitors into the Binding Pocket (2020) (0)
- Chapter 5 Induction of Mdr 1 b expression by tumor necrosis factor-α in rat liver cells is independent of p 53 but requires NF-κ B signaling (2002) (0)
- Differential Specificity of the Human and Mouse Multidrug Resistance Protein 4 (MRP4) Orthologs for Arsenic Metabolites (2016) (0)
- The Role of ABC Transporter Abcc4 in Platelets Physiologic Function and Its Impact On Collagen Meditated Platelet Aggregation (2012) (0)
- Exploiting ABCG2 Inhibition to Improve Cancer Therapy (2018) (0)
- Is Inhibitor Binding the Sole Requirement in Determining Inhibition of ABCG2 Mediated Transport? (2018) (0)
- A novel plasma membrane porphyrin transporter that affects porphyria (2017) (0)
- Determining the Effect of MRP4 Knockout on Pigment Granule Position in Mouse RPE (2018) (0)
- PPIX-binding Proteins Reveal Porphyrin Synthesis and Ferroptosis Link (2022) (0)
- ABC efflux transporters and drug toxicity (2019) (0)
- The heme biosynthetic pathway plays a crucial role in N-MYC myeloid leukemias (2015) (0)
- Conformation-sensing ABCG 2 antibody 1 FUNCTION-DEPENDENT CONFORMATIONAL CHANGES OF THE ABCG 2 MULTIDRUG TRANSPORTER MODIFY ITS INTERACTION WITH A MONOCLONAL ANTIBODY ON THE CELL SURFACE (2004) (0)
- Corrigendum to "Metabolic switching in pluripotent stem cells reorganizes energy metabolism and subcellular organelles" [379 (2019) 55-64]. (2019) (0)
- Hemoproteins ATP-Binding Cassette Transporter That Regulates Cell Survival under Stress Is Enhanced by a Mitochondrial (2009) (0)
- A Role for ABCC4 in Regulating Pigment Granule Aggregation in Mice (2019) (0)
- Morphogen Directed Coordination of GPCR Activity Promotes Primary Cilium Function for Downstream Signaling (2022) (0)
- Development and Validation of a Sensitive and Specific LC-MS/MS Method for IWR-1-Endo, a Wnt Signaling Inhibitor: Application to a Cerebral Microdialysis Study (2022) (0)
- University of Groningen Expression and regulation of ABC transporter genes during liver regeneration (2017) (0)
- DMD057539 541..545 (2014) (0)
- The ABC transporter Mrp4/Abcc4 is required for Leydig cell protection from chemotherapeutic drugs (844.1) (2014) (0)
- An Evolutionarily Conserved Residue in ABCG2 Regulates the Transport Cycle and Inhibitor Activity (2022) (0)
- Immunohistochemical analysis of multidrug resistance associated protein-4 (MRP4) expression in human normal and tumor tissues (2006) (0)
- Identification of ABCG2 Inhibitors as a New Combination Therapy to Improve Outcome in AML (2017) (0)
- Genetic Ablation of the ABC Transporter Abcc4 Impairs Lymphoid Leukemogenesis (2018) (0)
- Assessing the ABCG2 Protein Interactome: a Potential Strategy to Disrupt ABCG2 Function (2020) (0)
- Multidrug resistance protein 4 (Mrp4) regulates nutrient and energy metabolism by altering the adipose tissue physiology (2019) (0)
- An unexpected protein interaction promotes drug resistance in leukemia (2017) (0)
- Role in ABC transporters in liver functions and disease (2009) (0)
- Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure Service Email (2013) (0)
- Issue Information (2020) (0)
- Analysis of the human TPMT gene promoter (1997) (0)
- AML-144 Uroporphyrinogen Decarboxylase (UROD) Is a Therapeutically Targetable Dependency in Acute Erythroid Leukemia. (2022) (0)
- ABCB6, an ABC Transporter Impacting Drug Response and Disease (2017) (0)
- PLATELETS AND THROMBOPOIESIS The ABCC 4 membrane transporter modulates platelet aggregation (2015) (0)
- Abstract 1528: Abcc4 (Mrp4)-deficiency leads to decreased oral absorption of dasatinib (2010) (0)
- Up-regulation of the multidrug resistance gene Mdr1b by NF-KB in vitro and in vivo. (2000) (0)
- An ABC transporter as a potential target against SHH-Medulloblastoma: From Benchtop to Bedside (2022) (0)
- Functional inactivation of wildtype p53 leads to selective antifolate sensitivity by purine nucleotide depletion (1999) (0)
- Cell context of BCRP (ABCG2) affects clofarabine cytotoxicity (2008) (0)
- Issue Information (2020) (0)
- Functional interaction between Mrp4 (abcc4) and Bcrp (abcg2) as revealed by the single and double-knockout mouse (2006) (0)
- A Promiscuous Biotin Ligase as a Global Strategy to Interrogate the Protein Interactome of Human ABCC4 (2018) (0)
- Human Immunodeficiency Virus Protease Inhibitors Interact with ATP Binding Cassette Transporter 4 / Multidrug Resistance Protein 4 : A Basis for Unanticipated Enhanced Cytotoxicity s (2013) (0)
- Incorporation of fluoropyrimidine (FP) drugs into RNA as the major determinant of cytotoxicity in host and tumor cells (1982) (0)
- Mechanism of fluoropyrimidine (FP) toxicity in Ehrlich ascites tumor cells (EA); Inhibition of thymidylate synthetase activity (TSA) vs. incorporation into RNA at equitoxic doses of four FP drugs (1982) (0)
- The ABC transporter Mrp4 (Abcc4) plays a crucial role in normal testosterone production (2011) (0)
- The ABCs of Mitochondrial Metabolic Disorders (2011) (0)
- A novel role for OATP2A1/SLCO2A1 in a murine model of colon cancer (2017) (0)
- Retinal Vascular Development in Mrp 4-Knockout Mice (2012) (0)
- Determining the Molecular Characteristics of How Ligands Interact with an ABC Transporter (2019) (0)
- Demonstration and characterization of DNA repair in bone marrow cells following fluorouracil (FU) incubation (1985) (0)
- A Role For a Multi-Drug Resistance Protein (MRP4/ABCC4) In Pediatric Acute Myeloid Leukemia (AML) (2013) (0)
- N-Myc Is Overexpressed In Both Murine and Human Early T-Cell Precursor Leukemia and Is Sufficient To Initiate this Leukemia In Multipotent Primitive Arf-/- thymocytes (2013) (0)
- Dynamic Changes in ABCC4 Protein‐Protein Interactions during PKA Signaling: Role of the ABCC4 PDZ Motif (2022) (0)
- Stable MRP4 knockdown via retroviral vector mediated short interfering RNA (siRNA) sensitizes neuroblastoma (NB) cell lines to camptothecin analogs in vitro. (2006) (0)
- Heme-Sensing Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics (2020) (0)
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