John Edgar Dick
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Canadian cancer researcher
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Why Is John Edgar Dick Influential?
(Suggest an Edit or Addition)According to Wikipedia, John Edgar Dick is Canada Research Chair in Stem Cell Biology, Senior Scientist at the Princess Margaret Cancer Centre, University Health Network and Professor in the Department of Molecular Genetics at the University of Toronto in Canada. Dick is credited with first identifying cancer stem cells in certain types of human leukemia. His revolutionary findings highlighted the importance of understanding that not all cancer cells are the same and thus spawned a new direction in cancer research. Dick is also known for his demonstration of a blood stem cell's ability to replenish the blood system of a mouse, his development of a technique to enable an immune-deficient mouse to carry and produce human blood, and his creation of the world's first mouse with human leukemia.
John Edgar Dick's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell (1997) (6840)
- A cell initiating human acute myeloid leukaemia after transplantation into SCID mice (1994) (4659)
- A human colon cancer cell capable of initiating tumour growth in immunodeficient mice (2007) (4169)
- Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. (2006) (2967)
- Evolution of the cancer stem cell model. (2014) (1802)
- The genetic basis of early T-cell precursor acute lymphoblastic leukaemia (2012) (1437)
- Targeting of CD44 eradicates human acute myeloid leukemic stem cells (2006) (1184)
- Stem cell concepts renew cancer research. (2008) (1074)
- Mass cytometry: technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry. (2009) (1020)
- Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity (2004) (964)
- Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice. (1997) (927)
- Stem cell gene expression programs influence clinical outcome in human leukemia (2011) (916)
- Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy (1996) (825)
- Isolation of Single Human Hematopoietic Stem Cells Capable of Long-Term Multilineage Engraftment (2011) (790)
- Hematopoiesis: a human perspective. (2012) (774)
- Identification of pre-leukemic hematopoietic stem cells in acute leukemia (2014) (701)
- Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer (2013) (699)
- A newly discovered class of human hematopoietic cells with SCID-repopulating activity (1998) (650)
- Cancer stem cells: lessons from leukemia. (2005) (638)
- Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/Wv mice (1985) (631)
- Corrigendum: Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia (2014) (620)
- Distinct routes of lineage development reshape the human blood hierarchy across ontogeny (2016) (603)
- Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice. (1992) (576)
- Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia (2012) (560)
- A 17-gene stemness score for rapid determination of risk in acute leukaemia (2016) (531)
- Prediction of acute myeloid leukaemia risk in healthy individuals (2018) (517)
- Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. (2011) (514)
- Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay. (1997) (506)
- Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells. (2009) (498)
- Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development (2010) (478)
- Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells (2007) (462)
- Engraftment of immune-deficient mice with human hematopoietic stem cells. (1988) (456)
- Self-renewal as a therapeutic target in human colorectal cancer (2013) (446)
- Quantitative Analysis Reveals Expansion of Human Hematopoietic Repopulating Cells After Short-term Ex Vivo Culture (1997) (418)
- Bone Morphogenetic Proteins Regulate the Developmental Program of Human Hematopoietic Stem Cells (1999) (408)
- A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns (2016) (399)
- Tracing the origins of relapse in acute myeloid leukaemia to stem cells (2017) (374)
- Distinct classes of human stem cells that differ in proliferative and self-renewal potential (2001) (343)
- Breast cancer stem cells revealed (2003) (330)
- Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression (2005) (321)
- The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency (2011) (305)
- The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress (2014) (291)
- Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells (2003) (288)
- Immature human cord blood progenitors engraft and proliferate to high levels in severe combined immunodeficient mice. (1994) (283)
- Comparison of human cord blood engraftment between immunocompromised mouse strains. (2010) (268)
- Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia (1996) (263)
- A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal. (2010) (261)
- A model of human acute lymphoblastic leukemia in immune-deficient SCID mice. (1989) (260)
- Expansion of human cord blood CD34(+)CD38(-) cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell (SRC) frequency: dissociation of SRC phenotype and function. (2000) (255)
- Concepts of human leukemic development (2004) (254)
- Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice. (1997) (249)
- Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors (2012) (242)
- Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia. (2015) (233)
- Looking ahead in cancer stem cell research (2009) (230)
- Evolution of human BCR–ABL1 lymphoblastic leukaemia-initiating cells (2010) (220)
- CDK6 Levels Regulate Quiescence Exit in Human Hematopoietic Stem Cells (2015) (218)
- CD8(+) minor histocompatibility antigen-specific cytotoxic T lymphocyte clones eliminate human acute myeloid leukemia stem cells. (1999) (215)
- Evolution of human BCR–ABL1 lymphoblastic leukaemia-initiating cells (2011) (210)
- ID1 and ID3 regulate the self-renewal capacity of human colon cancer-initiating cells through p21. (2012) (204)
- Normal and leukemic SCID-repopulating cells (SRC) coexist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis. (1996) (202)
- AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress. (2015) (201)
- High level engraftment of NOD/SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid leukemia in chronic phase. (1998) (200)
- Transduction of human CD34+ CD38- bone marrow and cord blood-derived SCID-repopulating cells with third-generation lentiviral vectors. (2000) (200)
- Deregulation of DUX4 and ERG in acute lymphoblastic leukemia (2016) (197)
- The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment (2013) (197)
- Assay of human stem cells by repopulation of NOD/SCID mice (1997) (196)
- Identification of Hematopoietic Stem Cell–Specific miRNAs Enables Gene Therapy of Globoid Cell Leukodystrophy (2010) (192)
- Attenuation of miR-126 Activity Expands HSC In Vivo without Exhaustion (2012) (192)
- Engraftment and development of human CD34(+)-enriched cells from umbilical cord blood in NOD/LtSz-scid/scid mice. (1997) (190)
- Hematopoietic stem cell and progenitor defects in Sca-1/Ly-6A-null mice. (2003) (190)
- The evolution of cellular deficiency in GATA2 mutation. (2014) (186)
- A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies (2018) (185)
- Cancer stem cells in solid tumors: an overview. (2009) (178)
- Acute Myeloid Leukemia Stem Cells (2005) (173)
- Individual stem cells with highly variable proliferation and self-renewal properties comprise the human hematopoietic stem cell compartment (2006) (171)
- Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells. (2009) (168)
- Normal and leukemic human stem cells assayed in SCID mice. (1996) (162)
- Human short-term repopulating stem cells are efficiently detected following intrafemoral transplantation into NOD/SCID recipients depleted of CD122+ cells. (2005) (158)
- Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the human hematopoietic stem cell compartment and culture-induced stem cell impairment. (2004) (151)
- A recombinant bcl-x s adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells. (1995) (136)
- Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells. (2009) (135)
- miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells (2016) (135)
- Modeling the Initiation and Progression of Human Acute Leukemia in Mice (2007) (133)
- Quantitative single-cell proteomics as a tool to characterize cellular hierarchies (2019) (132)
- Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia. (2015) (131)
- Rescue of T cell-specific V(D)J recombination in SCID mice by DNA-damaging agents. (1994) (130)
- Multiple cellular antigen detection by ICP-MS. (2006) (130)
- Human acute myeloid leukemia stem cells. (2003) (127)
- Engraftment of human hematopoietic stem cells is more efficient in female NOD/SCID/IL-2Rgc-null recipients. (2010) (124)
- Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors. (2013) (122)
- Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts (2012) (121)
- Comment on "Tumor Growth Need Not Be Driven by Rare Cancer Stem Cells" (2007) (116)
- Direct evidence for cooperating genetic events in the leukemic transformation of normal human hematopoietic cells (2005) (112)
- Expression of bcr-abl abrogates factor-dependent growth of human hematopoietic M07E cells by an autocrine mechanism. (1994) (110)
- Gene transfer into hematopoietic stem cells: long-term maintenance of in vitro activated progenitors without marrow ablation. (1994) (109)
- Stem cells: Self-renewal writ in blood (2003) (109)
- Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia. (2016) (108)
- Biology of Normal and Acute Myeloid Leukemia Stem Cells (2005) (107)
- miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells (2016) (102)
- Nuclear localizing sequences promote nuclear translocation and enhance the radiotoxicity of the anti-CD33 monoclonal antibody HuM195 labeled with 111In in human myeloid leukemia cells. (2006) (102)
- Differential Maintenance of Primitive Human SCID-Repopulating Cells, Clonogenic Progenitors, and Long-Term Culture-Initiating Cells After Incubation on Human Bone Marrow Stromal Cells (1997) (101)
- Leukemia-initiating cells in human T-lymphoblastic leukemia exhibit glucocorticoid resistance. (2010) (100)
- PLZF is a regulator of homeostatic and cytokine-induced myeloid development. (2009) (95)
- Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells. (2011) (93)
- Low rhodamine 123 retention identifies long-term human hematopoietic stem cells within the Lin-CD34+CD38- population. (2007) (93)
- MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin. (2015) (92)
- Engraftment of immune-deficient mice with primitive hematopoietic cells from beta-thalassemia and sickle cell anemia patients: implications for evaluating human gene therapy protocols. (1995) (91)
- Differential maintenance of primitive human SCID-repopulating cells, clonogenic progenitors, and long-term culture-initiating cells after incubation on human bone marrow stromal cells. (1997) (90)
- Gene transfer into normal human hematopoietic cells using in vitro and in vivo assays. (1991) (86)
- Retroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cells. (1998) (85)
- Transplantation of Normal and Leukemic Human Bone Marrow into Immune‐Deficient Mice: Development of Animal Models for Human Hematopoiesis (1991) (85)
- Bone marrow failure in the Fanconi anemia group C mouse model after DNA damage. (1998) (84)
- Modulation of gene expression in multiple hematopoietic cell lineages following retroviral vector gene transfer. (1987) (83)
- Generation of drug-resistant variants in metastatic B16 mouse melanoma cell lines. (1987) (81)
- Human Solid Tumor Xenografts in Immunodeficient Mice Are Vulnerable to Lymphomagenesis Associated with Epstein-Barr Virus (2012) (80)
- Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance. (2018) (77)
- Expression of human adenosine deaminase in murine haematopoietic progenitor cells following retroviral transfer (1986) (74)
- Dynamic changes in cellular and microenvironmental composition can be controlled to elicit in vitro human hematopoietic stem cell expansion. (2005) (72)
- Inhibition of the LSD 1 ( KDM 1 A ) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia (2013) (68)
- Mutational landscape and patterns of clonal evolution in relapsed pediatric acute lymphoblastic leukemia. (2020) (67)
- Reduced lymphoid lineage priming promotes human hematopoietic stem cell expansion. (2014) (67)
- Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia. (2018) (67)
- Inherited myeloproliferative neoplasm risk impacts hematopoietic stem cells (2020) (67)
- Zebrafish microRNA-126 determines hematopoietic cell fate through c-Myb (2010) (66)
- AGS67E, an Anti-CD37 Monomethyl Auristatin E Antibody–Drug Conjugate as a Potential Therapeutic for B/T-Cell Malignancies and AML: A New Role for CD37 in AML (2015) (63)
- Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells. (2005) (61)
- Hematopoietic compartment of Fanconi anemia group C null mice contains fewer lineage-negative CD34+ primitive hematopoietic cells and shows reduced reconstruction ability. (1999) (61)
- Intercellular network structure and regulatory motifs in the human hematopoietic system (2014) (60)
- Enhanced megakaryocyte and erythroid development from normal human CD34(+) cells: consequence of enforced expression of SCL. (1998) (60)
- Expression of bcr-abl abrogates factor-dependent growth of human hematopoietic M07E cells by an autocrine mechanism (1994) (60)
- Relapse fated latent diagnosis subclones in acute B lineage leukaemia are drug tolerant and possess distinct metabolic programs. (2020) (59)
- Enhanced Megakaryocyte and Erythroid Development From Normal Human CD34+ Cells: Consequence of Enforced Expression of SCL (1998) (59)
- Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells (2017) (59)
- Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal (2019) (57)
- Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC. (2009) (57)
- Enhanced alternative splicing of the FLVCR1 gene in Diamond Blackfan anemia disrupts FLVCR1 expression and function that are critical for erythropoiesis (2008) (52)
- Ectopic miR-125a Expression Induces Long-Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors. (2016) (50)
- CC-90009, a novel cereblon E3 ligase modulator targets acute myeloid leukemia blasts and leukemia stem cells. (2020) (49)
- miRNA-126 Orchestrates an Oncogenic Program in B Cell Precursor Acute Lymphoblastic Leukemia. (2016) (49)
- Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms (2017) (46)
- Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia (2005) (42)
- Reversible cell surface expression of CD38 on CD34-positive human hematopoietic repopulating cells. (2007) (42)
- Acute myeloid leukemia. (2001) (41)
- Anaplastic large cell lymphoma-propagating cells are detectable by side population analysis and possess an expression profile reflective of a primitive origin (2014) (40)
- Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants (2013) (40)
- SCID mice as an in vivo model of human cord blood hematopoiesis. (1994) (40)
- A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside. (2012) (39)
- Auger Electron Radioimmunotherapeutic Agent Specific for the CD123+/CD131− Phenotype of the Leukemia Stem Cell Population (2011) (37)
- Hematopoietic Cell Fate and the Initiation of Leukemic Properties in Primitive Primary Human Cells Are Influenced by Ras Activity and Farnesyltransferase Inhibition (2004) (35)
- Engraftment of human lymphoid cells into newborn SCID mice leads to graft-versus-host disease. (1993) (35)
- The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells Is Governed by Dynamic 3D Genome Reorganization. (2020) (33)
- TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate. (2021) (33)
- Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo (2006) (32)
- The stem cell-associated gene expression signature allows risk stratification in pediatric acute myeloid leukemia (2018) (32)
- Dominant-negative Ikaros cooperates with BCR-ABL1 to induce human acute myeloid leukemia in xenografts (2014) (31)
- Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project (2011) (31)
- Molecular landscapes of human hematopoietic stem cells in health and leukemia (2015) (30)
- Enhancer hijacking drives oncogenic BCL11B expression in lineage ambiguous stem cell leukemia. (2021) (29)
- A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia (2022) (28)
- High efficiency error suppression for accurate detection of low-frequency variants (2019) (28)
- Genetic manipulation of hematopoietic stem cells with retrovirus vectors (1986) (28)
- Human stem cell assays in immune‐deficient mice (1996) (28)
- Biological and therapeutic implications of a unique subtype of NPM1 mutated AML (2021) (27)
- Immune-deficient mice as models of normal and leukemic human hematopoiesis. (1991) (27)
- Gene therapy turns the corner (2000) (26)
- In Vivo Dynamics of Human Stem Cell Repopulation in NOD/SCID Mice (2001) (26)
- Treatment of non-obese diabetic (NOD)/Severe-combined immunodeficient mice (SCID) with flt3 ligand and interleukin-7 impairs the B-lineage commitment of repopulating cells after transplantation of human hematopoietic cells. (1998) (25)
- Functional profiling of single CRISPR/Cas9-edited human long-term hematopoietic stem cells (2019) (23)
- Studies of mammalian ribonucleotide reductase activity in intact permeabilized cells: a genetic approach. (1980) (22)
- Characterization of Cord Blood Hematopoietic Stem Cells (2003) (22)
- CD200 expression marks leukemia stem cells in human AML. (2020) (21)
- Murine models of normal and neoplastic human haematopoiesis. (1992) (21)
- Gene Transfer with Retrovirus Vectors (1985) (21)
- Molecular and functional characterization of early human hematopoiesis (2012) (21)
- Normal and Leukemic Human Stem Cells (2000) (21)
- A stemness screen reveals C3orf54/INKA1 as a promoter of human leukemia stem cell latency. (2019) (20)
- SMYD2 lysine methyltransferase regulates leukemia cell growth and regeneration after genotoxic stress (2017) (20)
- Enhanced human hematopoietic stem and progenitor cell engraftment by blocking donor T cell–mediated TNFα signaling (2017) (19)
- Nicotinamide phosphoribosyltransferase inhibitors selectively induce apoptosis of AML stem cells by disrupting lipid homeostasis. (2021) (19)
- Differential kinetics of engraftment and induction of CD10 on human pre-B leukemia cell lines in immune deficient scid mice. (1992) (19)
- Membrane glycoprotein changes during the senescence of normal human diploid fibroblasts in culture (1985) (19)
- Mapping the cellular origin and early evolution of leukemia in Down syndrome (2020) (19)
- Human Aging Alters the Spatial Organization between CD34+ Hematopoietic Cells and Adipocytes in Bone Marrow (2020) (18)
- Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation. (2020) (18)
- Characterization and retroviral transduction of an early human lymphomyeloid precursor assayed in nonswitched long-term culture on murine stroma. (1999) (18)
- Future prospects for animal models created by transplanting human haematopoietic cells into immune-deficient mice. (1994) (17)
- A Quantitative Single-Cell Proteomics Approach to Characterize an Acute Myeloid Leukemia Hierarchy (2019) (16)
- An Integrated Analysis of Heterogeneous Drug Responses in Acute Myeloid Leukemia That Enables the Discovery of Predictive Biomarkers. (2016) (16)
- Ribonucleotide reduction in intact human diploid fibroblasts (1980) (16)
- Involvement of ribonucleotide reductase activity in the senescence of normal human diploid fibroblasts (1982) (16)
- Complexity of the human acute myeloid leukemia stem cell compartment: implications for therapy. (2005) (15)
- Genetic engineering of mouse and human stem cells. (1986) (15)
- Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling (2013) (14)
- A latent subset of human hematopoietic stem cells resists regenerative stress to preserve stemness (2021) (14)
- Retrovirus‐Mediated Gene Transfer into Hematopoietic Stem Cells a (1987) (14)
- Messenger RNA Detection in Leukemia Cell lines by Novel Metal-Tagged in situ Hybridization using Inductively Coupled Plasma Mass Spectrometry (2006) (14)
- A novel method for detecting the cellular stemness state in normal and leukemic human hematopoietic cells can predict disease outcome and drug sensitivity (2019) (13)
- Modeling human hematopoiesis in immunodeficient mice. (1993) (13)
- AGS62P1, a Novel Anti-FLT3 Antibody Drug Conjugate, Employing Site Specific Conjugation, Demonstrates Preclinical Anti-Tumor Efficacy in AML Tumor and Patient Derived Xenografts (2015) (13)
- CD 8 1 minor histocompatibility antigen-specific cytotoxic T lymphocyte clones eliminate human acute myeloid leukemia stem cells (1999) (13)
- HUMAN HEMATOPOIESIS IN SCID MICE (1995) (13)
- Short-term granulocyte colony-stimulating factor and erythropoietin treatment enhances hematopoiesis and survival in the mitomycin C-conditioned Fancc(-/-) mouse model, while long-term treatment is ineffective. (2002) (12)
- Absence of CD34 on Some Human SCID‐Repopulating Cells (1999) (12)
- Essential role for Ptpn 11 in survival of hematopoietic stem and progenitor cells (2011) (11)
- Mouse models for human hematopoiesis. (1991) (11)
- Immune-deficient mice as models for human hematopoietic disease. (1991) (11)
- The Role of PLZF in Human Myeloid Development (2009) (11)
- Global proteomics dataset of miR-126 overexpression in acute myeloid leukemia (2016) (9)
- Clonal haematopoiesis is associated with higher mortality in patients with cardiogenic shock (2022) (8)
- On the importance of deoxyribonucleotide pools in the senescence of cultured human diploid fibroblasts (1985) (8)
- Bone Marrow-derived Human Hematopoietic Stem Cells Engraft NOD/SCID Mice and Traffic Appropriately to an Inflammatory Stimulus in the Joint (2010) (8)
- Functional differences between myeloid leukemia-initiating and transient leukemia cells in Down's syndrome (2010) (8)
- Expression of MLL Fusion Genes in Human Hematopoietic Cells Is Sufficient To Induce Both Acute Lymphoid and Acute Myeloid Leukemia In Vivo . (2006) (8)
- Nicotinamide Phosphoribosyltransferase Inhibitors Selectively Induce Apoptosis of AML Stem Cells by Disrupting Lipid Homeostasis (2020) (7)
- Author Correction: A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies (2018) (7)
- An ERG enhancer-based reporter identifies leukemia cells with elevated leukemogenic potential driven by ERG-USP9X feed-forward regulation. (2019) (7)
- Leukemic Engraftment In NOD.SCID Mice Is Correlated With Clinical Parameters and Predicts Outcome In Human AML (2013) (7)
- High efficiency gene transfer and expression in normal murine B lymphocytes. (1987) (7)
- Problems with Co-Funding in Canada (2005) (7)
- Establishment of assays for human hematopoietic cells in immune deficient mice. (1989) (7)
- The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness (2018) (7)
- Tumor Archaeology: Tracking Leukemic Evolution to Its Origins (2014) (6)
- Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood (2020) (6)
- CD123 (IL-3 Receptor α Chain) Neutralization by a Monoclonal Antibody Selectively Eliminates Human Acute Myeloid Leukemic Stem Cells. (2007) (6)
- Stem cells take a shortcut to the bone marrow (2003) (6)
- Integration of intra-sample contextual error modeling for improved detection of somatic mutations from deep sequencing (2020) (6)
- Enriched MicroRNA-126 Bioactivity Marks the Primitive Compartment In AML and Regulates LSC Numbers (2010) (6)
- Human diploid fibroblasts with alterations in ribonucleotide reductase activity, deoxyribonucleotide pools and in vitro lifespan (1984) (6)
- Identification of human colon cancer initiating cells (2006) (5)
- Erratum: A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns (2016) (5)
- Significance of the SCID Mouse Models for the Study of Normal and Leukemic Human Hemopoiesis and Gene Therapy (1995) (5)
- High-level multilineage engraftment of human cord blood cells in SCID mice. (1993) (5)
- A Novel Cereblon E3 Ligase Modulator Eradicates Acute Myeloid Leukemia Stem Cells through Degradation of Translation Termination Factor GSPT1 (2019) (5)
- Abstract 5173: Genetic profiling of central nervous system dissemination of B-acute lymphoblastic leukemia reveals clonal selection and therapeutic vulnerability (2018) (5)
- Identification and characterization of in vitro expanded hematopoietic stem cells (2022) (5)
- A clinical laboratory–developed LSC17 stemness score assay for rapid risk assessment of patients with acute myeloid leukemia (2021) (5)
- Reconstructing Complex Cancer Evolutionary Histories from Multiple Bulk DNA Samples Using Pairtree (2022) (5)
- Anti-CD9 antibody, AR40A746.2.3, inhibits tumor growth in pancreatic and breast cancer models and recognizes CD9 on CD34+CD38- leukemic cancer stem cells. (2008) (5)
- Distinct patterns of clonal evolution in patients with concurrent myelo- and lymphoproliferative neoplasms. (2018) (4)
- SmMIP-tools: a computational toolset for processing and analysis of single-molecule molecular inversion probes derived data (2021) (4)
- Multiomic Profiling of Central Nervous System Leukemia Identifies mRNA Translation as a Therapeutic Target. (2021) (4)
- PLAG1 dampens protein synthesis to promote human hematopoietic stem cell self-renewal (2022) (4)
- Development of a Novel NOD/SCID Transplant System That Provides Enhanced Detection of Rapid-SRC and Insight into Their Self-Renewal and Mobilization. (2004) (4)
- The evolution of cellular de fi ciency in GATA 2 mutation (2014) (4)
- DNMT3a Mutations Define a Pre-Leukemic Stem Cell Reservoir In Human Acute Myeloid Leukemia (2013) (4)
- MicroRNA Expression Profiling in Sorted AML Subpopulations: A Possible Role for miR-155/BIC in Stem Cell Maintenance and Leukemogenesis. (2005) (4)
- Dichotomous regulation of lysosomes by MYC and TFEB controls hematopoietic stem cell fate (2020) (4)
- Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells (2020) (4)
- INPP4B promotes leukemia by restricting leukemic stem cell differentiation through regulation of lysosomal functions (2021) (4)
- Functional differences between myeloid leukemia-initiating and transient leukemia cells in Down's syndrome (2010) (3)
- Cellular and molecular architecture of hematopoietic stem cells and progenitors in genetic models of bone marrow failure. (2019) (3)
- Targeting the Mitochondrial Metallochaperone Cox17 Reduces DNA Methylation and Promotes AML Differentiation through a Copper Dependent Mechanism (2018) (3)
- High Content Screening Identifies Synthetic Lethality Of Retinoid Receptor Agonists In IKZF1-Mutated BCR-ABL1 positive Acute Lymphoblastic Leukemia (2013) (3)
- Functional and Phenotypic Heterogeneity of the Human Hematopoietic Stem Cell (HSC) Compartment (2008) (3)
- Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation. (2021) (3)
- Variation in Stem Cell Driven Hierarchies Underlies Clinical Outcome and Drug Response in AML (2020) (3)
- Multiplex Biomarker Detection by ICP‐MS (2006) (3)
- Defining Functional Heterogeneity In Acute Lymphoblastic Leukemia (2013) (3)
- Characterization of inv(3) cell line OCI-AML-20 with stroma-dependent CD34 expression. (2019) (3)
- Genetic predisposition to myeloproliferative neoplasms implicates hematopoietic stem cell biology (2019) (3)
- Inhibition of Mitochondrial Translation As a Therapeutic Strategy for Acute Myeloid Leukemia (AML) (2011) (2)
- A Highly Selective Anti-ROR1 Monoclonal Antibody Inhibits Human Acute Myeloid Leukemia CD34+ Cell Survival and Self-Renewal. (2012) (2)
- Mir-126 Governs Human Leukemia Stem Cell Quiescence and Chemotherapy Resistance (2013) (2)
- Isolation of CD34− and CD34+ Leukemia Stem Cells from Acute Myeloid Leukemia Blasts Using CD200 (2018) (2)
- Clonal hematopoiesis confers an increased mortality risk in orthotopic heart transplant recipients (2022) (2)
- Lysosomal Disruption Selectively Targets Leukemia Cells and Leukemia Stem Cells Through A Mechanism Related to Increased Reactive Oxygen Species Production (2011) (2)
- Mir-125b Regulates the Self-Renewal of Acute Myeloid Leukemia Stem Cells through PTPN18 and GSK3 (2020) (2)
- An improved molecular inversion probe based targeted sequencing approach for low variant allele frequency (2022) (2)
- 3 Are cancer stem cells relevant (2010) (2)
- A Novel Predictor of Response to Gemtuzumab Ozogamicin Therapy in AML Provides Strategies for Sensitization of Leukemia Stem Cells in Individual Patients (2018) (2)
- "Human, mouse and dog bone marrow show similar mesenchymal stromal cells within a distinctive microenvironment". (2021) (2)
- Correction: Corrigendum: Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors (2013) (2)
- CD200 Is a Marker of LSC Activity in Acute Myeloid Leukemia (2016) (2)
- A cellular hierarchy framework for understanding heterogeneity and predicting drug response in AML (2022) (2)
- Genome-Wide shRNA Screen for DNA Damage Response Regulators in Human Hematopoietic Stem and Progenitor Cells (2011) (2)
- Pairtree: fast reconstruction of cancer evolutionary history using pairwise mutation relationships (2020) (2)
- Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML. (2022) (2)
- Q&A: John Dick on stem cells and cancer. (2013) (2)
- G protein-coupled receptor 56 as a potential regulator of normal and leukemic stem cells (2015) (1)
- Understanding Pre-Leukemia in Trisomy 21 Human HSC and Modeling Progression Towards Down Syndrome Associated Leukemia Using CRISPR/Cas9 at Single Cell Resolution (2019) (1)
- Cellular and Molecular Architecture of Hematopoietic Stem Cells and Progenitors in Genetic Models of Bone Marrow Failure (2019) (1)
- Ribonucleotide reductase activity during the senescence of normal human diploid fibroblasts in culture (1985) (1)
- 104 Tumor Microenvironment and Genetic Association With Colorectal Cancer Risk (2012) (1)
- Identification of existing bioactive molecules that target acute myeloid leukemia stem cells (2016) (1)
- A cluster of enhancer modules directs differential MYC expression along the normal and leukemic haematopoietic stem cell hierarchies (2017) (1)
- 506 POSTER The apogenic anti-CD9 antibody, AR40A746.2.3, inhibits tumor growth in breast and pancreatic cancer and targets cancer stem cells in acute myeloid leukemia (2008) (1)
- Evolving heterogeneity in acute lymphoblastic leukemia (2014) (1)
- Accessibility Over Transposable Elements Reveals Genetic Determinants of Stemness Properties in Normal and Leukemic Hematopoiesis (2021) (1)
- Developing Applicable and Cost-Efficient Screens for Early Detection of AML (2018) (1)
- In vivo screening unveils pervasive RNA-binding protein dependencies in leukemic stem cells and identifies ELAVL1 as a therapeutic target. (2023) (1)
- Genetic Analysis of B-Cell Acute Lymphoblastic Leukemia Dissemination to the Central Nervous System Identifies Clonal Selection and Therapeutic Vulnerability (2018) (1)
- Donor Chip Causes Donor-Derived Clonal Hematopoiesis As an Early Complication of Allogeneic Stem Cell Transplantation (2016) (1)
- Indium-111 labeled anti-CD33 monoclonal antibodies (mAbs) modified with nuclear-localizing sequences (NLS) kill mitoxantrone-resistant HL-60 acute myelogenous leukemia (AML) cells (2006) (1)
- On the Origins of AML Relapse (2015) (1)
- A novel CD34-specific T-cell engager efficiently depletes acute myeloid leukemia and leukemic stem cells in vitro and in vivo (2022) (1)
- A Novel CD34-Specific T-Cell Engager Efficiently Depletes Stem Cells and Acute Myeloid Leukemia Cells in Vitro and In Vivo (2021) (1)
- Nicotinamide Phosphoribosyltransferase Inhibitors Induce Apoptosis of AML Stem Cells through Dysregulation of Lipid Metabolism (2020) (1)
- Abstract 4792: Elucidating stem cell-specific metabolic pathways in normal and malignant hematopoiesis to target human acute myeloid leukemia stem cells (2014) (1)
- HSCs Fated to Progress to Blast Phase Can be Detected in Myelofibrosis Patients Several Years Prior to Leukemic Transformation (2019) (1)
- Efficacy and Safety of Allogeneic Double Negative T Cell As a Cellular Therapy for AML and Its Underlying Mechanism (2015) (1)
- Southern analysis on small numbers of cells (1987) (1)
- Relapse-Initiating Clones Preexisting at Diagnosis in B- Cell Acute Lymphoblastic Leukemia Help Predict Molecular Pathways of Relapse (2018) (1)
- Genomic Landscape of Relapsed Acute Lymphoblastic Leukemia (2015) (1)
- Identification of Existing Bioactive Compounds That Target Acute Myeloid Leukemia Stem Cells (2015) (1)
- Mir-125a Confers Multi-Lineage Long-Term Repopulating Stem Cell Activity to Human Hematopoietic Committed Progenitors (2015) (1)
- A primary patient-derived model for investigating functional heterogeneity within the human Leukemic Stem Cell Compartment (2022) (1)
- The Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia (2018) (1)
- A Mechanistic Role For Mir-126, a Hematopoietic Stem Cell Microrna, In Acute Leukemias (2013) (1)
- A primary hierarchically organized patient-derived model enables in depth interrogation of stemness driven by the coding and non-coding genome (2022) (1)
- 3002 – CIRCADIAN CUES REPROGRAM METABOLIC PATHWAYS IN LONG-TERM REPOPULATING HEMATOPOIETIC STEM CELLS (2022) (0)
- Hematopoiesis and Stem Cells collections : Blood (2009) (0)
- Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia (2020) (0)
- In vivo characterization of human double negatve T cells as a potential novel immunotherapy for AML (2013) (0)
- Measured by the Quantitative In Vivo SCID-Repopulating Cell Assay Compared With Adult Bone Marrow or Mobilized Peripheral Blood as Primitive Human Hematopoietic Cells Are Enriched in Cord Blood (2010) (0)
- A Distinct Subset of Human Blood Stem Cells Resists Regenerative Stress to Preserve Stemness (2020) (0)
- Redefining the human blood progenitor hierarchy across development (2015) (0)
- Stem cell in cancer: Do they matter? (2015) (0)
- Sphingosine-1-Phosphate Receptor 3 (S1PR3) Promotes Myeloid Commitment of Human Hematopoietic and Leukemic Stem Cells (2018) (0)
- Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity. (2023) (0)
- Identification of a New Genetic Determinant Controlling Human Hematopoietic Stem Cell Engraftment. (2007) (0)
- High Levels of MicroRNA-126 Bioactivity Specify the LSC Compartment in AML (2008) (0)
- Abstract PR07: MicroRNA-130a regulates hematopoietic stem cell self-renewal and erythroid differentiation (2017) (0)
- Antonija Kreso Response in Colorectal Cancer Variable Clonal Repopulation Dynamics Influence Chemotherapy (2013) (0)
- Human hematopoietic stem cell integrity is guarded by the unfolded protein response (2013) (0)
- Histone H3 Methylation Mediates All- Trans -Retinoic Acid Responsiveness in Acute Myeloid Leukemia (2011) (0)
- Sphingolipids Regulate Myeloid-Erythroid Fate Determination in Human Hematopoiesis (2016) (0)
- Sphingolipid Perturbation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal (2018) (0)
- Discovery of a New Human Hematopoietic Stem Cell Involved with Aging That Retains Memory of Immune Activation (2022) (0)
- Development of ERG-Enhancer Fluorescent Reporter System to Decipher Functional Heterogeneity in Leukemia (2018) (0)
- High-throughput screening for compounds toxic to human leukemic cells derived from lineage-depleted cord blood cells (2007) (0)
- Abstract 1013: Enriched miR-126 bioactivity marks the primitive compartment in human AML and regulates leukemia stem cell numbers (2012) (0)
- 3099 – REPRESSION OF TBL1XR1 BY MIR-130A REINFORCES THE ABERRANT MOLECULAR PROGRAM IN T(8,21) AML (2020) (0)
- SmMIP-tools: a computational toolset for processing and analysis of single-molecule molecular inversion probes-derived data (2022) (0)
- Abstract 907: Efficacy of SAR302503, a JAK2 inhibitor, in primary human acute myeloid leukemia xenografts. (2013) (0)
- Simultaneous Inhibition of SIRT3 and Cholesterol Homeostasis Targets AML Stem Cells By Perturbing Fatty Acid β-Oxidation and Inducing Lipotoxicity (2022) (0)
- Technique helps target microRNA. (2014) (0)
- Characterization of Tumour-initiating Cells in Human Colorectal Cancer (2012) (0)
- ALL-144: Oncogenic Deregulation of BCL11B in Lineage Ambiguous Leukemia (2021) (0)
- ERG ENHANCER-BASED REPORTER IDENTIFIES LEUKEMIA CELLS WITH ELEVATED LEUKEMOGENIC POTENTIAL DRIVEN BY ERG-USP9X FEED-FORWARD REGULATION (2019) (0)
- Researchers identify stem cell origin of AML. (2014) (0)
- Comprehensive Genomic Screens Reveal Multiple Modes of Action of the PLZF-RAR-α Oncoprotein (2008) (0)
- Abstract A176: Efficacy and safety of allogeneic double negative T cell as anti-AML therapy and its underlying mechanism (2016) (0)
- 2ND STEM CELL SYMPOSIUM Cancer Stem Cells (2014) (0)
- Uncovering Distinct Metabolic Properties of Relapse and Relapse-Fated Clones in B-Cell Acute Lymphoblastic Leukemia (2022) (0)
- Chimeric anti-CD44 antibodies and their use for the treatment of acute myeloid leukemia (2004) (0)
- Abstract IA10: The role of stem cells in the origin of relapse in acute leukemia (2016) (0)
- Mouse Model for Shwachman-Diamond Syndrome with the R126T Disease Mutation Leads to Severe Growth and Developmental Deficiencies with Impairment of Hematopoiesis. (2006) (0)
- Acute Myeloid Leukemia Stem Cells Escape Innate Immune Surveillance by Macrophages through Interaction with SIRPα (2010) (0)
- Clonal Analysis of the Human Hematopoietic Hierarchy Reveals An Early Lymphoid Progenitor with Extensive Monocytic Potential. (2009) (0)
- Transcriptional Activation of Regenerative Hematopoiesis via Vascular Niche Sensing (2023) (0)
- Genome-wide shRNA screening approach towards identification and characterization of therapy resistance determinants in leukemia (2013) (0)
- Inactivation of Stage-Specific B-Cell Commitment Genes Generates Distinct Molecular Subtypes of BCR-ABL1 Lymphoblastic Leukemia (2018) (0)
- Abstract LB-58: Spontaneous Epstein Barr virus-associated lymphomagenesis in primary human solid tumor xenografts (2011) (0)
- Adaptation to ex vivo culture drives human haematopoietic stem cell loss of repopulation capacity in a cell cycle independent manner (2023) (0)
- Functional Assays for Human AML Cells by Transplantation into SCID Mice (1996) (0)
- PLAGL2 Independently Drives Aberrant Erythropoiesis and Initiation of Preleukemic State (2021) (0)
- Molecular and Functional Characterization of Early Lineage Commitment of Human Hematopoietic Stem Cells (2011) (0)
- Abstract 3330: Functional characterization of microRNAs identified in human acute myeloid leukemia stem cells (2012) (0)
- Abstracts of a Focused Workshop on Malignant Stem Cells in Leukemia and Solid Tumors Cambridge Ontario, Canada, May 7–9, 2004Sponsored by The Leukemia and Lymphoma Society (2004) (0)
- KDM6A loss sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition (2022) (0)
- Molecular Events Defining Human Clonal Hematopoiesis at Single Cell Resolution (2016) (0)
- Abstract 12: Metastatic neuroblastoma cancer stem cells display a mixed phenotype of tumor and niche origin required for survival (2010) (0)
- CD47-Sirpα Interaction Modulates Homing and Engraftment of Human Acute Myeloid Leukemia Stem Cells in Mice. (2009) (0)
- impairment cell human hematopoietic stem cell compartment and culture-induced stem Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the (2013) (0)
- Abstract A04: Differential dependence on sphingolipid metabolism in the normal and leukemic human hematopoietic hierarchy (2016) (0)
- AML Cells Have Altered Mitochondrial Biogenesis and Low Spare Reserve Capacity in Their Respiratory Chain That Renders Them Susceptible to Oxidative Metabolic Stress. (2012) (0)
- Abstract A51: Identification of compounds targeting human leukemia stem cells (2009) (0)
- A Human Model of Down Syndrome Associated Leukemia Reveals Different Cell of Origins for Initiation and Progression (2020) (0)
- The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells is Governed by Dynamic 3D Genome Reorganization (2020) (0)
- Leukemia-Initiating Cells in Acute Megakaryoblastic Leukemia and Transient Leukemia of Down Syndrome. (2007) (0)
- Leukemic and Normal Stem Cell Transcriptional Signatures Determined by Functional Assays Are Predictive of the Overall Survival of AML Patients. (2009) (0)
- Biological and therapeutic implications of a unique subtype of NPM1 mutated AML (2021) (0)
- Leukemic Stem Cell Expression Signatures Identify Novel Therapeutics for Acute Myeloid Leukemia (2017) (0)
- Hematopoietic Stem Cell Expansion, without Exhaustion or Transformation, by Stable Microrna Antagonism in Vivo (2012) (0)
- Identification of Single Human Hematopoietic Stem Cells Capable of Long-Term Multilineage Engraftment and Self-Renewal. (2009) (0)
- International Symposium and Workshop on Hematopoietic Stem Cells VII, University of Tübingen, Germany, September 18–20, 2008 (2009) (0)
- Efficacy of SAR302503, a JAK2 Inhibitor, in the Treatment of a Primary Xenograft Model of Human Acute Myeloid Leukemia, (2011) (0)
- Clinical significance of clonal hematopoiesis in the setting of autologous stem cell transplantation for lymphoma (2021) (0)
- Identification of Global miRNA Targetomes within Human Hematopoietic Progenitors and Acute Myeloid Leukemia Uncovers Unique Molecular Networks Centered on Mitochondria Function in Leukemic Stem Cells (2022) (0)
- Abstract 2650: Ags67e, an anti-cd37 monomethyl auristatin e antibody (mmae) drug conjugate as a potential therapeutic for non-hodgkin's lymphoma, chronic lymphocytic leukemia and acute myeloid leukemia (2014) (0)
- Activated JAK2 Signaling in Primary Human Hematopoietic Cells Drives Erythropoietin-Independent Erythropoiesis and Myelofibrosis. (2005) (0)
- miR-130a Regulates Hematopoietic Stem Cell Self-Renewal by Repressing Several Chromatin Modifiers and Its Overexpression is Associated with Acute Myeloid Leukemia (2018) (0)
- Abstract 2292: Enforced expression of miR-125b promotes the in vivo expansion of human Lin- CB multi-lymphoid progenitors (MLP) and AML leukemia stem cells. (2013) (0)
- Comprar Hematopoietic Stem Cells VI | Willem E. Fibbe | 9781573316767 | Blackwell Publishing (2007) (0)
- Bone Marrow Failure in the Fanconi Anemia Group C Mouse Model After (2013) (0)
- Enforced Expression Of Mir-125b Promotes the in vivo expansion Of Human Linneg cord Blood Multi-Lymphoid Progenitors and Leukemia Stem Cells (2013) (0)
- Myelofibrosis Is Initiated and Sustained By Rare Multipotent Stem Cells (2018) (0)
- The First Fully Experimental In Vivo Model of Human Leukemogenesis: Human Hematopoietic Stem Cells Infected with MLL-ENL Induce Pro-B Acute Lymphoblastic Leukemia in NOD/SCID Mice. (2005) (0)
- INPP4B drives lysosome biogenesis to restrict leukemic stem cell differentiation and promote leukemogenesis (2022) (0)
- MAMMAL COMPROSING WASCULARIZED FETAL, ORGAN TISSUE (2017) (0)
- Prediction of acute myeloid leukaemia risk in healthy individuals (2018) (0)
- Modeling the Initiation and Evolution of Down Syndrome Associated Leukemia Using CRISPR/Cas9 (2018) (0)
- Modulation of Histone H3K4 and H3K27 Methylation Levels Via Pharmacological Inhibition of LSD1 and Degradation of the EZH2-Containing Polycomb Repressive Complex 2 Stimulates ATRA-Mediated Differentiation of AML Cells. (2009) (0)
- AML-Fated Clones Arise in Stem and Progenitor Cells in Myelofibrosis Patients Several Years Prior to AML Diagnosis (2018) (0)
- Introduction (2007) (0)
- Abstract A25: Evolving functional heterogeneity in B-acute lymphoblastic leukemia (2016) (0)
- 111In-NLS-(Hu)M195 anti-CD33 antibodies kill multidrug resistant (MDR) acute myelogenous leukemia (AML) cell lines and primary AML specimens (2007) (0)
- Elevated Expression of Mir-130a in t(8,21) AML Reinforces the Aberrant Molecular Program of AML1-ETO (2020) (0)
- Identification of the Global miR-130a Targetome Reveals a Novel Role for TBL1XR1 in Hematopoietic Stem Cell Self-Renewal and t(8;21) AML (2021) (0)
- A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies (2018) (0)
- A two-step in vivo CRISPR screen unveils pervasive RNA binding protein dependencies for leukemic stem cells and identifies ELAVL1 as a therapeutic target (2021) (0)
- A Novel Role for PLK1 in Leukemia Stem Cell Function in Acute Myeloid Leukemia (2022) (0)
- Overexpression of the h-ras oncogene in primary primitive human hematopoietic cells alters proliferation and differentiation (2000) (0)
- Functional Investigation of the Argonaute Proteins in Human Hematopoietic Stem and Progenitor Cells (2020) (0)
- Distinct Regulatory Networks Govern Human Hematopoietic Stem Cell Across Development (2015) (0)
- Human SIRPA Polymorphism Modulates Macrophage-Mediated Suppression of Human Hematopoiesis (2008) (0)
- A Stemness Screen Reveals C3ORF54/INKA1 As a Gate-Keeper of Human Stem Cell Latency (2018) (0)
- SRC within the Lin-CD34+CD38+/Lo Population Possess Heterogeneous Migration, Repopulation, and Self-Renewal Potential. (2004) (0)
- Comparing Human Fetal Liver, Cord Blood and Adult Bone Marrow Stem/Progenitor Hematopoietic Cells As Cells of Origin of Human MLL Leukemias (2011) (0)
- Stem Cell-Derived Gene Expression Scores Predict Survival and Leukemic Transformation in Myelofibrosis (2022) (0)
- Abstracts of a Focused Workshop on Malignant Stem Cells in Leukemia and Solid Tumors Cambridge Ontario, Canada, May 7–9, 2004 (2004) (0)
- Functional heterogeneity of human hematopoietic stem cells assayed by retroviral gene marking and repopulation of immunodeficient mice (2000) (0)
- MicroSPECT/CT Imaging of Human Leukemia Engraftment In NOD-Scid Mice Using [111In]-Labeled 7G3 Anti-CD123 Antibodies (2010) (0)
- Erythropoiesis Failure in Diamond-Blackfan Anemia Starts at the Oligopotent Common Myeloid and Megakaryocyte-Erythroid Progenitor Stage (2020) (0)
- Modeling the Multi-Step Pathogenesis of Acute Myeloid Leukemia of Down Syndrome (2014) (0)
- miR-126 Regulates Distinc t Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells Graphical (0)
- Abstract 3476: Profiling CD antigens signature in human hepatocellular carcinoma (HCC) by cell-based high-throughput screening flow cytometry (HTS-FC) (2014) (0)
- MIR-125A CONFERS MULTI-LINEAGE LONG-TERM REPOPULATING STEM CELL ACTIVITY TO MURINE AND HUMAN HEMATOPOIETIC PROGENITORS (2016) (0)
- 3147 – SPHINGOSINE-1-PHOSPHATE RECEPTOR 3 SIGNALING DEPLETES LEUKEMIA STEM CELLS BY INDUCING DIFFERENTIATION (2020) (0)
- 3229 – MODELING CLONAL HEMATOPOIESIS AND THE PRE-LEUKEMIC STATE WITH CHR13Q DELETION IN HUMAN HEMATOPOIETIC STEM CELLS (2022) (0)
- Animal Models of Normal and Leukemic Human Hematopoiesis (1992) (0)
- Dissecting the cellular of down syndrome TMD and AMKL (2017) (0)
- KDM6 Demethylases Integrate DNA Repair Gene Regulation: Loss of KDM6A Sensitizes AML to PARP Inhibition and Potentiates with BCL2 Blockade (2021) (0)
- Abstract SY13-01: Genetic and non-genetic mechanisms contribute to long term clonal growth dynamics and therapy resistance (2013) (0)
- 58 – High Resolution Clonal Marking-Analysis (2004) (0)
- Identification and Characterization of Human Leukemia Stem Cell Functional Regulators (2011) (0)
- Identification and Function of Hematopoietic Stem and Progenitor Cell Specific Micrornas. (2010) (0)
- Engraftment Patterns in NOD.SCID Mice Predict Outcome in Human AML (2014) (0)
- Liver Fibrosis In Myeloid Leukemia of Down Syndrome (2010) (0)
- 2002 – GENETIC PREDISPOSITION TO MYELOPROLIFERATIVE NEOPLASMS IMPLICATES HEMATOPOIETIC STEM CELL BIOLOGY (2020) (0)
- Point: AML Stem Cells are Immature, Rare, and Targets for Curative Therapy in AML. (2009) (0)
- Deep Multi-Omics Profiling in Cytogenetically Poor-Risk AML (2022) (0)
- Linking Subclonal Genetic Diversity with Functional Heterogeneity Identifies Diagnosis Subclones Destined to Relapse (2016) (0)
- Preface for Hematopoietic Stem Cells VIII (2012) (0)
- Opposing Evolutionary Pressures Drive Clonal Evolution and Health Outcomes in the Aging Blood System (2020) (0)
- Competitive in vivo screening of 64 candidate leukemia stem cell self-renewal regulators selects for genes protracting stem cell latency (2017) (0)
- LMO2 and TAL1 Cooperate in a Model of Human T−Cell Leukemogenesis. (2006) (0)
- Chromatin Accessibility Identifies CTCF As a Gatekeeper of Stemness Functions in Human Hematopoietic Development (2016) (0)
- Abstract IA21: Stem cells play a role in human leukemia from origin to relapse (2020) (0)
- Identification of Gene Regulatory Networks Governing Stemness Properties of Human HSC and LSC (2018) (0)
- Functional and Phenotypic Characterization Of Acute Myeloid Leukemia By Analysis Of Diagnostic/Relapse Paired Samples (2013) (0)
- Genetic Manipulation of Human Hematopoietic Stem Cells (1989) (0)
- Identification and characterization of therapy resistance determinants in leukemia (2014) (0)
- 3017 – A DISTINCT SUBSET OF LATENT LONG-TERM HUMAN HEMATOPOIETIC STEM CELLS RESISTS REGENERATIVE STRESS TO PRESERVES STEMNESS (2020) (0)
- Deep Phenotypic Characterization of Primitive Stem and Progenitor Compartments Reveals the Cellular Architecture of Aplastic Anemia. (2012) (0)
- Abstract 4538: Inhibition of mitochondrial protein synthesis with antimicrobial tigecycline preferentially induces cell death in leukemia cells (2010) (0)
- KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition (2023) (0)
- Divergent Levels of CD112 and INKA1 Define a Subset of Human Hematopoietic Stem Cells That Resists Regenerative Stress to Preserve Stemness (2020) (0)
- Faiyaz Notta Long-Term Multilineage Engraftment Isolation of Single Human Hematopoietic Stem Cells Capable (2011) (0)
- Abstract 2914: Phosphoproteomic and transcriptional biomarkers predict response to SAR302503, a JAK2 inhibitor, in human acute myeloid leukemia preclinical models (2014) (0)
- The Human Blood Hierarchy Is Shaped By Distinct Progenitor Lineages Across Development (2015) (0)
- Novel immunotherapy for AML using DNT cells (P4348) (2013) (0)
- Modulation of gene expression in multiple hematopoietic cell lineages following retroviral vector gene transfer ( stem cells / gene regulation ) (0)
- Microrna-130a Regulates Hematopoietic Stem Cell Self-Renewal By Repressing Chromatin Modifiers and Shaping the Accessible Chromatin Landscape (2018) (0)
- Purification and Characterization of a Cell Initiating Human Acute Leukemia after Transplantation into NOD-SCID Mice (1998) (0)
- Abstract 3496: Self-renewal as a therapeutic target in human colorectal cancer (2012) (0)
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