John Frank Carpenter
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John Frank Carpenterchemistry Degrees
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Chemical Engineering
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Chemistry
John Frank Carpenter's Degrees
- Masters Chemical Engineering Stanford University
- Bachelors Chemical Engineering University of California, Berkeley
Why Is John Frank Carpenter Influential?
(Suggest an Edit or Addition)John Frank Carpenter's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Physical Stability of Proteins in Aqueous Solution: Mechanism and Driving Forces in Nonnative Protein Aggregation (2003) (1249)
- The role of vitrification in anhydrobiosis. (1998) (1195)
- Stabilization of dry phospholipid bilayers and proteins by sugars. (1987) (863)
- An infrared spectroscopic study of the interactions of carbohydrates with dried proteins. (1989) (671)
- Dehydration-induced conformational transitions in proteins and their inhibition by stabilizers. (1993) (652)
- Rational Design of Stable Lyophilized Protein Formulations: Some Practical Advice (1997) (609)
- Interactions of sugars with membranes. (1988) (605)
- The mechanism of cryoprotection of proteins by solutes. (1988) (563)
- Factors affecting short-term and long-term stabilities of proteins. (2001) (560)
- Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality. (2009) (506)
- Hydrogen bonding between sugar and protein is responsible for inhibition of dehydration-induced protein unfolding. (1999) (471)
- Are freezing and dehydration similar stress vectors? A comparison of modes of interaction of stabilizing solutes with biomolecules (1990) (452)
- Modes of interaction of cryoprotectants with membrane phospholipids during freezing. (1987) (447)
- Surface-induced denaturation of proteins during freezing and its inhibition by surfactants. (1996) (446)
- Infrared spectroscopic studies of lyophilization- and temperature-induced protein aggregation. (1995) (441)
- The ice nucleation temperature determines the primary drying rate of lyophilization for samples frozen on a temperature-controlled shelf. (2001) (347)
- Separation of freezing- and drying-induced denaturation of lyophilized proteins using stress-specific stabilization. I. Enzyme activity and calorimetric studies. (1993) (320)
- Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony‐stimulating factor (2003) (310)
- Tween protects recombinant human growth hormone against agitation-induced damage via hydrophobic interactions. (1998) (279)
- Annealing to optimize the primary drying rate, reduce freezing-induced drying rate heterogeneity, and determine T(g)' in pharmaceutical lyophilization. (2001) (271)
- Effects of Tween 20 and Tween 80 on the stability of Albutropin during agitation. (2005) (267)
- A specific molar ratio of stabilizer to protein is required for storage stability of a lyophilized monoclonal antibody. (2001) (262)
- Stabilization of phosphofructokinase with sugars during freeze-drying: characterization of enhanced protection in the presence of divalent cations. (1987) (261)
- The basis for toxicity of certain cryoprotectants: A hypothesis (1990) (257)
- Silicone oil- and agitation-induced aggregation of a monoclonal antibody in aqueous solution. (2009) (250)
- Separation of freezing- and drying-induced denaturation of lyophilized proteins using stress-specific stabilization. II. Structural studies using infrared spectroscopy. (1993) (235)
- Effect of Tween 20 on freeze-thawing- and agitation-induced aggregation of recombinant human factor XIII. (1998) (230)
- Rational design of stable lyophilized protein formulations: theory and practice. (2002) (220)
- Protein instability and immunogenicity: roadblocks to clinical application of injectable protein delivery systems for sustained release. (2012) (216)
- Preferential exclusion of sucrose from recombinant interleukin-1 receptor antagonist: role in restricted conformational mobility and compaction of native state. (1997) (206)
- Protein denaturation during freezing and thawing in phosphate buffer systems: monomeric and tetrameric beta-galactosidase. (2000) (201)
- BSA degradation under acidic conditions: a model for protein instability during release from PLGA delivery systems. (2006) (195)
- Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis. (2003) (194)
- Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: essential need to use orthogonal methods to assure the quality of therapeutic protein products. (2010) (192)
- IgG particle formation during filling pump operation: a case study of heterogeneous nucleation on stainless steel nanoparticles. (2009) (190)
- Potential induction of anti-PEG antibodies and complement activation toward PEGylated therapeutics. (2014) (186)
- Antifreeze protein modulates cell survival during cryopreservation: mediation through influence on ice crystal growth. (1992) (182)
- A transient expansion of the native state precedes aggregation of recombinant human interferon-gamma. (1998) (180)
- Aggregation of granulocyte colony stimulating factor under physiological conditions: characterization and thermodynamic inhibition. (2002) (180)
- Effects of solution conditions, processing parameters, and container materials on aggregation of a monoclonal antibody during freeze-thawing. (2008) (180)
- Polymers protect lactate dehydrogenase during freeze-drying by inhibiting dissociation in the frozen state. (1996) (174)
- Silicone oil microdroplets and protein aggregates in repackaged bevacizumab and ranibizumab: effects of long-term storage and product mishandling. (2011) (173)
- Studies of the structure of insulin fibrils by Fourier transform infrared (FTIR) spectroscopy and electron microscopy. (2001) (172)
- High pressure fosters protein refolding from aggregates at high concentrations. (1999) (170)
- Survival of water stress in annual fish embryos: dehydration avoidance and egg envelope amyloid fibers. (2001) (169)
- Response of a concentrated monoclonal antibody formulation to high shear (2009) (169)
- Quantitation of aggregate levels in a recombinant humanized monoclonal antibody formulation by size-exclusion chromatography, asymmetrical flow field flow fractionation, and sedimentation velocity. (2007) (166)
- Modes of stabilization of a protein by organic solutes during desiccation (1988) (164)
- Immunogenicity of aggregates of recombinant human growth hormone in mouse models. (2009) (162)
- Understanding and modulating opalescence and viscosity in a monoclonal antibody formulation. (2010) (160)
- Quantitation of the area of overlap between second-derivative amide I infrared spectra to determine the structural similarity of a protein in different states. (1996) (160)
- Protein–Solvent Interactions in Pharmaceutical Formulations (1991) (158)
- Aggregation of recombinant human interferon gamma: kinetics and structural transitions. (1998) (157)
- Cryopreservation of stem cells using trehalose: evaluation of the method using a human hematopoietic cell line. (2004) (157)
- Protein formulation and lyophilization cycle design: prevention of damage due to freeze-concentration induced phase separation. (1999) (154)
- Application of infrared spectroscopy to development of stable lyophilized protein formulations. (1998) (148)
- Subvisible particle counting provides a sensitive method of detecting and quantifying aggregation of monoclonal antibody caused by freeze-thawing: insights into the roles of particles in the protein aggregation pathway. (2011) (147)
- Physical factors affecting the storage stability of freeze-dried interleukin-1 receptor antagonist: glass transition and protein conformation. (1996) (145)
- Infrared and circular dichroism spectroscopic characterization of structural differences between beta-lactoglobulin A and B. (1996) (143)
- Inhibition of stress-induced aggregation of protein therapeutics. (1999) (143)
- Monoclonal antibody interactions with micro- and nanoparticles: adsorption, aggregation, and accelerated stress studies. (2009) (142)
- Effects of surfaces and leachables on the stability of biopharmaceuticals. (2011) (140)
- Effects of sucrose on conformational equilibria and fluctuations within the native‐state ensemble of proteins (2003) (136)
- Protein aggregation and particle formation in prefilled glass syringes. (2014) (134)
- Cryoprotection of phosphofructokinase with organic solutes: characterization of enhanced protection in the presence of divalent cations. (1986) (134)
- Comparison of Solute-Induced Protein Stabilization in Aqueous Solution and in the Frozen and Dried States (1990) (133)
- Optimization of storage stability of lyophilized actin using combinations of disaccharides and dextran. (2000) (132)
- Thermodynamic Modulation of Light Chain Amyloid Fibril Formation* (2000) (129)
- Temperature-dependent perturbation of phospholipid bilayers by dimethylsulfoxide. (1992) (125)
- Stabilization of phosphofructokinase during air-drying with sugars and sugar/transition metal mixtures. (1987) (123)
- Counteracting effects of thiocyanate and sucrose on chymotrypsinogen secondary structure and aggregation during freezing, drying, and rehydration. (1996) (121)
- Effects of drying methods and additives on structure and function of actin: mechanisms of dehydration-induced damage and its inhibition. (1998) (118)
- Congo Red Populates Partially Unfolded States of an Amyloidogenic Protein to Enhance Aggregation and Amyloid Fibril Formation* (2003) (118)
- Heterogeneous nucleation-controlled particulate formation of recombinant human platelet-activating factor acetylhydrolase in pharmaceutical formulation. (2005) (117)
- Protein adsorption and excipient effects on kinetic stability of silicone oil emulsions. (2010) (116)
- Effects of antifreeze proteins on red blood cell survival during cryopreservation. (1996) (115)
- Surface adsorption of recombinant human interferon-gamma in lyophilized and spray-lyophilized formulations. (2002) (115)
- Effect of glycine on pH changes and protein stability during freeze-thawing in phosphate buffer systems. (2002) (113)
- Effects of additives on the stability of recombinant human factor XIII during freeze-drying and storage in the dried solid. (1998) (112)
- Characterization and quantitation of aggregates and particles in interferon-β products: potential links between product quality attributes and immunogenicity. (2013) (110)
- Dry powders of stable protein formulations from aqueous solutions prepared using supercritical CO(2)-assisted aerosolization. (2001) (109)
- Manipulation of Lyophilization‐Induced Phase Separation: Implications For Pharmaceutical Proteins (1997) (108)
- Maintenance of quaternary structure in the frozen state stabilizes lactate dehydrogenase during freeze-drying. (2001) (101)
- Inhibition of agitation-induced aggregation of an IgG-antibody by hydroxypropyl-beta-cyclodextrin. (2010) (101)
- Precipitation of a monoclonal antibody by soluble tungsten. (2009) (99)
- Aggregation of a monoclonal antibody induced by adsorption to stainless steel (2010) (99)
- Effects of phase separating systems on lyophilized hemoglobin. (1996) (97)
- Production of particles of therapeutic proteins at the air–water interface during compression/dilation cycles (2012) (95)
- Solid state chemistry of proteins: II. The correlation of storage stability of freeze-dried human growth hormone (hGH) with structure and dynamics in the glassy solid. (2008) (95)
- Spectroscopic study of secondary structure and thermal denaturation of recombinant human factor XIII in aqueous solution. (1997) (91)
- High hydrostatic pressure as a tool to study protein aggregation and amyloidosis. (2002) (91)
- Maintenance of transfection rates and physical characterization of lipid/DNA complexes after freeze-drying and rehydration. (1997) (90)
- High Pressure Refolding of Recombinant Human Growth Hormone from Insoluble Aggregates (2001) (89)
- Mechanisms of interaction of amino acids with phospholipid bilayers during freezing. (1988) (87)
- Interactions of stabilizing additives with proteins during freeze-thawing and freeze-drying. (1992) (86)
- Entrapping intermediates of thermal aggregation in alpha-helical proteins with low concentration of guanidine hydrochloride. (2000) (85)
- Counteracting Effects of Renal Solutes on Amyloid Fibril Formation by Immunoglobulin Light Chains* (2001) (85)
- Intermolecular β-Sheet Results from Trifluoroethanol-Induced Nonnative α-Helical Structure in β-Sheet Predominant Proteins: Infrared and Circular Dichroism Spectroscopic Study (1998) (83)
- Partial molar volume, surface area, and hydration changes for equilibrium unfolding and formation of aggregation transition state: High-pressure and cosolute studies on recombinant human IFN-γ (2001) (83)
- Flow cytometry: a promising technique for the study of silicone oil-induced particulate formation in protein formulations. (2011) (82)
- Effects of annealing lyophilized and spray-lyophilized formulations of recombinant human interferon-gamma. (2003) (81)
- Concomitant Raman spectroscopy and dynamic light scattering for characterization of therapeutic proteins at high concentrations. (2015) (79)
- Evidence of partial unfolding of proteins at the ice/freeze-concentrate interface by infrared microscopy. (2009) (79)
- Rational Design of Stable Protein Formulations (2002) (79)
- Lyophilization-induced protein denaturation in phosphate buffer systems: monomeric and tetrameric beta-galactosidase. (2001) (78)
- Effects of pH, temperature, and sucrose on benzyl alcohol-induced aggregation of recombinant human granulocyte colony stimulating factor. (2006) (78)
- Rational design of stable protein formulations : theory and practice (2002) (78)
- Effects of additives on the stability of Humicola lanuginosa lipase during freeze-drying and storage in the dried solid. (1999) (75)
- Do not drop: mechanical shock in vials causes cavitation, protein aggregation, and particle formation. (2015) (75)
- HIGH-MOLECULAR-WEIGHT AGGREGATES IN REPACKAGED BEVACIZUMAB (2010) (74)
- Secondary structures of proteins adsorbed onto aluminum hydroxide: infrared spectroscopic analysis of proteins from low solution concentrations. (2006) (74)
- Interactions of Stabilizers with Proteins During Freezing and Drying. (1995) (74)
- Mouse Models for Assessing Protein Immunogenicity: Lessons and Challenges. (2016) (74)
- Gelation of a monoclonal antibody at the silicone oil-water interface and subsequent rupture of the interfacial gel results in aggregation and particle formation. (2015) (74)
- Anhydrobiosis: cellular adaptations to extreme dehydration. (1997) (73)
- Physical instability of a therapeutic Fc fusion protein: domain contributions to conformational and colloidal stability. (2009) (73)
- The effects of excipients on protein aggregation during agitation: an interfacial shear rheology study. (2013) (73)
- Protease autolysis in heavy-duty liquid detergent formulations: effects of thermodynamic stabilizers and protease inhibitors (2004) (72)
- High concentration formulations of recombinant human interleukin-1 receptor antagonist: II. Aggregation kinetics. (2008) (72)
- A new mechanism for decreasing aggregation of recombinant human interferon-gamma by a surfactant: slowed dissolution of lyophilized formulations in a solution containing 0.03% polysorbate 20. (2002) (71)
- Preparation of Active Proteins, Vaccines and Pharmaceuticals as Fine Powders using Supercritical or Near-Critical Fluids (2008) (70)
- IgG1 aggregation and particle formation induced by silicone-water interfaces on siliconized borosilicate glass beads: a model for siliconized primary containers. (2013) (70)
- Engineering challenges of protein formulations (2007) (69)
- Glass particles as an adjuvant: a model for adverse immunogenicity of therapeutic proteins. (2011) (68)
- Drug delivery matrix containing native protein precipitates suspended in a poloxamer gel. (1997) (67)
- Effects of drying methods and additives on the structure, function, and storage stability of subtilisin: role of protein conformation and molecular mobility (2002) (66)
- Use of infrared spectroscopy to assess secondary structure of human growth hormone within biodegradable microspheres. (1999) (66)
- Ionic strength affects tertiary structure and aggregation propensity of a monoclonal antibody adsorbed to silicone oil-water interfaces. (2013) (65)
- Particles shed from syringe filters and their effects on agitation-induced protein aggregation. (2012) (64)
- Effects of Sugars and Polymers on Crystallization of Poly(ethylene glycol) in Frozen Solutions: Phase Separation Between Incompatible Polymers (1996) (64)
- Functional analysis of cryopreserved veins (1990) (63)
- Optimizing storage stability of lyophilized recombinant human interleukin-11 with disaccharide/hydroxyethyl starch mixtures. (2004) (63)
- Rescue of cystathionine beta-synthase (CBS) mutants with chemical chaperones: purification and characterization of eight CBS mutant enzymes. (2010) (62)
- Real-Time in Situ Monitoring of Lysozyme During Lyophilization Using Infrared Spectroscopy: Dehydration Stress in the Presence of Sucrose (1997) (61)
- Effects of solutes on solubilization and refolding of proteins from inclusion bodies with high hydrostatic pressure (2006) (61)
- Inhibition of aggregation of aluminum hydroxide adjuvant during freezing and drying. (2008) (61)
- Investigation of the Immunogenicity of Different Types of Aggregates of a Murine Monoclonal Antibody in Mice (2015) (60)
- Postproduction Handling and Administration of Protein Pharmaceuticals and Potential Instability Issues. (2018) (59)
- Analytical approaches to assess the degradation of therapeutic proteins (2013) (59)
- The excluding effects of sucrose on a protein chemical degradation pathway: methionine oxidation in subtilisin. (2000) (58)
- Kinetics and Energetics of Assembly, Nucleation, and Growth of Aggregates and Fibrils for an Amyloidogenic Protein (2002) (57)
- Mechanism for benzyl alcohol-induced aggregation of recombinant human interleukin-1 receptor antagonist in aqueous solution. (2004) (57)
- pH-Induced Metabolic Transitions in Artemia Embryos Mediated by a Novel Hysteretic Trehalase (1986) (57)
- Mechanisms Involved in the Protection of UV-induced Protein Inactivation by the Corneal Crystallin ALDH3A1* (2007) (56)
- Adsorption of monoclonal antibodies to glass microparticles. (2011) (56)
- Freezing- and Drying-Induced Perturbations of Protein Structure and Mechanisms of Protein Protection by Stabilizing Additives (1999) (55)
- Excipient effects on humanized monoclonal antibody interactions with silicone oil emulsions. (2012) (54)
- The effects of Tween 20 and sucrose on the stability of anti-L-selectin during lyophilization and reconstitution. (2001) (54)
- Controlling deamidation rates in a model peptide: effects of temperature, peptide concentration, and additives. (2001) (54)
- Ligand-induced conformational and structural dynamics changes in Escherichia coli cyclic AMP receptor protein. (2002) (53)
- Effect of secondary structure on the activity of enzymes suspended in organic solvents. (1996) (53)
- Development of a Stable Freeze-dried Formulation of Recombinant Human Interleukin-1 Receptor Antagonist (1996) (53)
- Influence of particle size and antigen binding on effectiveness of aluminum salt adjuvants in a model lysozyme vaccine. (2008) (52)
- Effects of storage temperature on viable bioprosthetic heart valves. (1992) (51)
- Stability of lipid/DNA complexes during agitation and freeze-thawing. (1998) (51)
- Functional analysis of cryopreserved veins. Preliminary report. (1990) (50)
- Preservation of Differentiation and Clonogenic Potential of Human Hematopoietic Stem and Progenitor Cells during Lyophilization and Ambient Storage (2010) (49)
- Aggregation and Particle Formation of Therapeutic Proteins in Contact With a Novel Fluoropolymer Surface Versus Siliconized Surfaces: Effects of Agitation in Vials and in Prefilled Syringes. (2016) (49)
- Comparative fourier transform infrared and circular dichroism spectroscopic analysis of alpha1-proteinase inhibitor and ovalbumin in aqueous solution. (2000) (49)
- High‐pressure refolding of bikunin: Efficacy and thermodynamics (2004) (49)
- Calcium-induced changes to the molecular conformation and aggregate structure of beta-casein at the air-water interface. (2005) (48)
- High-pressure studies on protein aggregates and amyloid fibrils. (2006) (47)
- Role of electrostatic repulsion on colloidal stability of Bacillus halmapalus alpha-amylase. (2009) (46)
- Formation of an active dimer during storage of interleukin-1 receptor antagonist in aqueous solution. (1996) (46)
- In Vivo Analysis of the Potency of Silicone Oil Microdroplets as Immunological Adjuvants in Protein Formulations. (2015) (45)
- Effect of zinc binding and precipitation on structures of recombinant human growth hormone and nerve growth factor. (2000) (45)
- Noninvasive determination of protein conformation in the solid state using near infrared (NIR) spectroscopy. (2005) (45)
- Approaches for increasing the solution stability of proteins. (1995) (45)
- Effects of phenol and meta-cresol depletion on insulin analog stability at physiological temperature. (2014) (45)
- Measurement of the second osmotic virial coefficient for protein solutions exhibiting monomer-dimer equilibrium. (2008) (44)
- Identification of strombine and taurine as cryoprotectants in the intertidal bivalve Mytilus edulis (1988) (44)
- Thermal Stability of Low Molecular Weight Urokinase During Heat Treatment. II. Effect of Polymeric Additives (1994) (44)
- Oxidation of methionine residues in recombinant human interleukin-1 receptor antagonist: implications of conformational stability on protein oxidation kinetics. (2007) (42)
- Protein quantity on the air-solid interface determines degradation rates of human growth hormone in lyophilized samples. (2014) (42)
- Quantification of glycine crystallinity by near-infrared (NIR) spectroscopy. (2004) (42)
- Stability of a trivalent recombinant protein vaccine formulation against botulinum neurotoxin during storage in aqueous solution. (2009) (41)
- Temperature dependence of benzyl alcohol- and 8-anilinonaphthalene-1-sulfonate-induced aggregation of recombinant human interleukin-1 receptor antagonist. (2006) (41)
- Freezing-induced perturbation of tertiary structure of a monoclonal antibody. (2014) (40)
- Ultraviolet radiation decreases expression and induces aggregation of corneal ALDH3A1. (2003) (40)
- Stability of Human Serum Albumin During Bioprocessing: Denaturation and Aggregation During Processing of Albumin Paste (2000) (39)
- High concentration formulations of recombinant human interleukin-1 receptor antagonist: I. Physical characterization. (2008) (39)
- Stabilization of a recombinant ricin toxin A subunit vaccine through lyophilization. (2013) (39)
- Surfactant Effects on Particle Generation in Antibody Formulations in Pre-filled Syringes. (2015) (39)
- Protein Aggregation and Particle Formation: Effects of Formulation, Interfaces, and Drug Product Manufacturing Operations (2010) (38)
- Microparticles and Nanoparticles Delivered in Intravenous Saline and in an Intravenous Solution of a Therapeutic Antibody Product. (2017) (38)
- Application of a thermodynamic model to the prediction of phase separations in freeze-concentrated formulations for protein lyophilization. (1999) (37)
- Effects of potassium bromide disk formation on the infrared spectra of dried model proteins. (2004) (37)
- Structural and Functional Modifications of Corneal Crystallin ALDH3A1 by UVB Light (2010) (36)
- Conformational stability of lyophilized PEGylated proteins in a phase-separating system. (1999) (36)
- Transmission electron microscopy as an orthogonal method to characterize protein aggregates. (2015) (35)
- Influence of protein conformation and adjuvant aggregation on the effectiveness of aluminum hydroxide adjuvant in a model alkaline phosphatase vaccine. (2009) (35)
- Temperature adaptation in Gillichthys (Teleost: Gobiidae) A(4)-lactate dehydrogenases: identical primary structures produce subtly different conformations. (2002) (35)
- Effect of the siliconization method on particle generation in a monoclonal antibody formulation in pre-filled syringes. (2015) (35)
- Critical evaluation and guidance for using the Coulter method for counting subvisible particles in protein solutions. (2012) (35)
- Colloidal Instability Fosters Agglomeration of Subvisible Particles Created by Rupture of Gels of a Monoclonal Antibody Formed at Silicone Oil-Water Interfaces. (2016) (34)
- Effects of benzyl alcohol on aggregation of recombinant human interleukin-1-receptor antagonist in reconstituted lyophilized formulations. (2005) (34)
- Effects of sucrose on rFVIIa aggregation and methionine oxidation. (2004) (33)
- In Vivo Fluorescence Imaging of IgG1 Aggregates After Subcutaneous and Intravenous Injection in Mice (2013) (33)
- High‐Pressure Refolding of Disulfide‐Cross‐Linked Lysozyme Aggregates: Thermodynamics and Optimization (2002) (33)
- Secondary structure of antifreeze proteins from overwintering larvae of the beetle Dendroides canadensis. (1998) (32)
- Arrestment of carbohydrate metabolism during anaerobic dormancy and aerobic acidosis inArtemia embryos: determination of pH-sensitive control points (1986) (32)
- Cryopreservation of Human Hematopoietic Stem and Progenitor Cells Loaded with Trehalose: Transient Permeabilization via the Adenosine Triphosphate-Dependent P2Z Receptor Channel (2005) (32)
- High‐pressure studies of aggregation of recombinant human interleukin‐1 receptor antagonist: Thermodynamics, kinetics, and application to accelerated formulation studies (2005) (32)
- Light-induced aggregation of type I soluble tumor necrosis factor receptor. (2009) (32)
- Effect of salts and sugars on phase separation of polyvinylpyrrolidone[ndash ]dextran solutions induced by freeze-concentration (1998) (31)
- Characterization of amorphous solids with weak glass transitions using high ramp rate differential scanning calorimetry. (2008) (31)
- Infrared microscopy for in situ measurement of protein secondary structure during freezing and freeze-drying. (2007) (31)
- Buffer-dependent fragmentation of a humanized full-length monoclonal antibody. (2010) (31)
- Cryoprotective capacity of end products of anaerobic metabolism (1989) (30)
- Long‐Term Storage of Proteins (2002) (30)
- Quantitation of dimethyl sulfoxide in solutions and tissues by high-performance liquid chromatography. (1991) (29)
- Dose levels in particulate-containing formulations impact anti-drug antibody responses to murine monoclonal antibody in mice. (2015) (29)
- Recombinant murine growth hormone particles are more immunogenic with intravenous than subcutaneous administration. (2014) (29)
- Some Lessons Learned From a Comparison Between Sedimentation Velocity Analytical Ultracentrifugation and Size Exclusion Chromatography to Characterize and Quantify Protein Aggregates. (2017) (29)
- Accelerated stability studies of abatacept formulations: comparison of freeze-thawing- and agitation-induced stresses. (2012) (29)
- Selective domain stabilization as a strategy to reduce fusion protein aggregation. (2012) (28)
- UV photodegradation of murine growth hormone: chemical analysis and immunogenicity consequences. (2014) (28)
- Physical stability of albinterferon-α(2b) in aqueous solution: effects of conformational stability and colloidal stability on aggregation. (2012) (28)
- Evaluation of chemical degradation of a trivalent recombinant protein vaccine against botulinum neurotoxin by LysC peptide mapping and MALDI-TOF mass spectrometry. (2009) (27)
- Mixing properties of lyophilized protein systems: a spectroscopic and calorimetric study. (2009) (27)
- Partial unfolding of a monoclonal antibody: role of a single domain in driving protein aggregation. (2014) (27)
- Silicone Oil Microdroplets Can Induce Antibody Responses Against Recombinant Murine Growth Hormone in Mice. (2016) (27)
- Characterization of Nanoparticle Tracking Analysis for Quantification and Sizing of Submicron Particles of Therapeutic Proteins. (2015) (27)
- Conformational properties of nine purified cystathionine β-synthase mutants. (2012) (26)
- Albinterferon α2b adsorption to silicone oil-water interfaces: effects on protein conformation, aggregation, and subvisible particle formation. (2014) (26)
- Characterization of Sizes of Aggregates of Insulin Analogs and the Conformations of the Constituent Protein Molecules: A Concomitant Dynamic Light Scattering and Raman Spectroscopy Study. (2016) (26)
- Purification and characterization of two polymorphic variants of short chain acyl-CoA dehydrogenase reveal reduction of catalytic activity and stability of the Gly185Ser enzyme. (2002) (25)
- Contributions of local mobility and degree of retention of native secondary structure to the stability of recombinant human growth hormone (rhGH) in glassy lyophilized formulations (2013) (25)
- Storage stability of keratinocyte growth factor-2 in lyophilized formulations: effects of formulation physical properties and protein fraction at the solid-air interface. (2014) (25)
- Effects of Tubing Type, Formulation, and Postpumping Agitation on Nanoparticle and Microparticle Formation in Intravenous Immunoglobulin Solutions Processed With a Peristaltic Filling Pump. (2019) (24)
- Population balance modeling of aggregation kinetics of recombinant human interleukin-1 receptor antagonist. (2005) (24)
- Pressure effect on subtilisin crystallization and solubility (1999) (23)
- Glassy-state stabilization of a dominant negative inhibitor anthrax vaccine containing aluminum hydroxide and glycopyranoside lipid A adjuvants. (2015) (23)
- Reversible dissociation and inactivation of phosphofructokinase in the ischemic rat heart. (1986) (23)
- Immunogenicity of Structurally Perturbed Hen Egg Lysozyme Adsorbed to Silicone Oil Microdroplets in Wild-Type and Transgenic Mouse Models. (2017) (23)
- Structure of Proteins in Lyophilized Formulations Using Fourier Transform Infrared Spectroscopy. (1995) (23)
- Effects of Excipients on the Chemical and Physical Stability of Glucagon during Freeze-Drying and Storage in Dried Formulations (2012) (23)
- Hydrophobic ion pairing as a method for enhancing structure and activity of lyophilized subtilisin BPN' suspended in isooctane. (1997) (23)
- Antibody responses in mice to particles formed from adsorption of a murine monoclonal antibody onto glass microparticles. (2014) (23)
- Comparison of pH-dependent allostery and dissociation for phosphofructokinases from Artemia embryos and rabbit muscle: nature of the enzymes acylated with diethylpyrocarbonate. (1986) (22)
- Effect of pH on stability of recombinant botulinum serotype A vaccine in aqueous solution and during storage of freeze-dried formulations. (2008) (21)
- The effect of mutations on the structure of insulin fibrils studied by Fourier transform infrared (FTIR) spectroscopy and electron microscopy. (2002) (20)
- Long-term preservation of dried phosphofructokinase by sugars and sugar/zinc mixtures. (1988) (20)
- Characterization of Factors Affecting Nanoparticle Tracking Analysis Results With Synthetic and Protein Nanoparticles. (2016) (20)
- Quaternary conformational stability: The effect of reversible self‐association on the fibrillation of two insulin analogs (2011) (19)
- Aggregation of recombinant human botulinum protein antigen serotype C in varying solution conditions: implications of conformational stability for aggregation kinetics. (2011) (19)
- Impact of Ethylene Oxide Sterilization of Polymer-Based Prefilled Syringes on Chemical Degradation of a Model Therapeutic Protein During Storage. (2019) (19)
- Effects of protein perturbants on phospholipid bilayers. (1990) (17)
- Using X-Ray Crystallography to Simplify and Accelerate Biologics Drug Development. (2017) (17)
- Stability of Subtilisin and Lysozyme under High Hydrostatic Pressure (2000) (17)
- Investigations into the fouling mechanism of parvovirus filters during filtration of freeze-thawed mAb drug substance solutions. (2014) (17)
- Effects of solution conditions and surface chemistry on the adsorption of three recombinant botulinum neurotoxin antigens to aluminum salt adjuvants. (2007) (17)
- Thermal stability of low molecular weight urokinase during heat treatment. III. Effect of salts, sugars and Tween 80 (1996) (17)
- Preformulation study of highly purified inactivated polio vaccine, serotype 3. (2014) (16)
- pH-induced hysteretic properties of phosphofructokinase purified from rat myocardium. (1986) (16)
- Selective domain stabilization as a strategy to reduce human serum albumin-human granulocyte colony stimulating factor aggregation rate. (2012) (16)
- Particle Formation and Aggregation of a Therapeutic Protein in Nanobubble Suspensions. (2016) (15)
- Cryoprotection of antibody by organic solutes and organic solute/divalent cation mixtures. (1988) (15)
- Two decades of publishing excellence in pharmaceutical biotechnology. (2015) (15)
- Immunogenicity of Isogenic IgG in Aggregates and Immune Complexes (2017) (15)
- Impact of Sterilization Method on Protein Aggregation and Particle Formation in Polymer-Based Syringes. (2017) (15)
- Measurement of Tg in lyophilized protein and protein excipient mixtures by dynamic mechanical analysis (2009) (15)
- In-Depth Comparison of Lysine-Based Antibody-Drug Conjugates Prepared on Solid Support Versus in Solution (2018) (15)
- Formation of Stable Nanobubbles on Reconstituting Lyophilized Formulations Containing Trehalose. (2016) (14)
- Reduced Subvisible Particle Formation in Lyophilized Intravenous Immunoglobulin Formulations Containing Polysorbate 20. (2016) (14)
- Perturbations of Protein Structure and Mechanisms of Protein Protection by Stabilizing Additives (2004) (14)
- Infrared spectroscopic studies of protein formulations containing glycine. (2004) (14)
- Infrared Spectroscopic Studies of Lyophi I izat ion- and Temperat u re4 nd uced Protein Aggregation (1995) (13)
- Effect of benzyl alcohol on recombinant human interleukin-1 receptor antagonist structure and hydrogen-deuterium exchange. (2011) (13)
- alphaT244M mutation affects the redox, kinetic, and in vitro folding properties of Paracoccus denitrificans electron transfer flavoprotein. (1997) (13)
- Phase-Appropriate Application of Analytical Methods to Monitor Subvisible Particles Across the Biotherapeutic Drug Product Life Cycle (2019) (12)
- A Platform for Preparing Homogeneous Proteinaceous Subvisible Particles With Distinct Morphologies. (2018) (12)
- Biophysical Properties and Heating-Induced Aggregation of Lysine-Conjugated Antibody-Drug Conjugates. (2018) (12)
- The Role of Protein Excipient in Driving Antibody Responses to Erythropoietin. (2015) (12)
- Intermolecular beta-sheet results from trifluoroethanol-induced nonnative alpha-helical structure in beta-sheet predominant proteins: infrared and circular dichroism spectroscopic study. (1998) (12)
- Aggregation of human serum albumin during a thermal viral inactivation step. (2009) (12)
- Protein Nanoparticles Promote Microparticle Formation in Intravenous Immunoglobulin Solutions During Freeze-Thawing and Agitation Stresses. (2018) (12)
- Calorimetric determination of inhibition of ice crystal growth by antifreeze protein in hydroxyethyl starch solutions. (1993) (12)
- DEHP Nanodroplets Leached from Polyvinyl Chloride IV Bags Promote Aggregation of IVIG and Activate Complement in Human Serum. (2020) (11)
- Mechanical Shock During Shipping of Medications: The Roles of Packaging and Transportation Vendors. (2020) (11)
- Effects of Product Handling Parameters on Particle Levels in a Commercial Factor VIII Product: Impacts and Mitigation. (2019) (10)
- Effects of tubing type, operating parameters and surfactants on particle formation during peristaltic filling pump processing of a monoclonal antibody formulation. (2020) (10)
- The Impact Of Formulation Composition And Process Settings Of Traditional Batch Versus Continuous Freeze-Drying On Protein Aggregation. (2020) (10)
- Conjugation of Emtansine Onto Trastuzumab Promotes Aggregation of the Antibody-Drug Conjugate by Reducing Repulsive Electrostatic Interactions and Increasing Hydrophobic Interactions. (2019) (10)
- Impact of heat treatment on miscibility of proteins and disaccharides in frozen solutions. (2013) (9)
- The Critical Need for Robust Assays for Quantitation and Characterization of Aggregates of Therapeutic Proteins (2012) (9)
- Secondary structure of recombinant human cystathionine beta-synthase in aqueous solution: effect of ligand binding and proteolytic truncation. (1997) (8)
- Formation of protein sub-visible particles during vacuum degassing of etanercept solutions. (2014) (8)
- Optimization of Infrared Microscopy to Assess Secondary Structure of Insulin Molecules Within Individual Subvisible Particles in Aqueous Formulations. (2019) (7)
- Lyophilization of Protein Pharmaceuticals (2020) (7)
- Analyzing insulin samples by size-exclusion chromatography: a column degradation study. (2015) (7)
- Rescue of Cystathionine β-Synthase (CBS) Mutants with Chemical Chaperones (2010) (7)
- Thermal analysis and crystallization kinetics of high-temperature thermoplastics (1988) (6)
- Effects of solution conditions on methionine oxidation in albinterferon alfa-2b and the role of oxidation in its conformation and aggregation. (2013) (6)
- Implant-assisted unilateral removable partial dentures. (2014) (6)
- Urea Improves Stability of Inactivated Polio Vaccine Serotype 3 During Lyophilization and Storage in Dried Formulations. (2018) (6)
- Application of a Best Practice Approach Using Resonant Mass Measurement for Biotherapeutic Product Characterization. (2019) (5)
- Subvisible and Visible Particle Analysis in Biopharmaceutical Research and Development (2015) (5)
- Spectroscopic Evidence of Tertiary Structural Differences Between Insulin Molecules in Fibrils. (2019) (4)
- Corrigendum to ''Measurement of the second osmotic virial coefficient for protein solutions exhibiting monomer-dimer equilibrium" (Anal. Biochem. 377 (2008) 128-133) (2008) (4)
- Use of Analytical Ultracentrifugation as an Orthogonal Method for Size Exclusion Chromatography: Assuring Quality for Therapeutic Protein Products and Meeting Regulatory Expectations (2016) (4)
- Substandard Quality of the Antimicrobials Sold in the Street Markets in Haiti (2020) (4)
- Mimicking Low pH Virus Inactivation Used in Antibody Manufacturing Processes - Effect of Processing Conditions and Biophysical Properties on Antibody Aggregation and Particle Formation. (2021) (3)
- Submicrometer, micrometer and visible particle analysis in biopharmaceutical research and development (2020) (3)
- Silicone oil‐free syringes, siliconized syringes and needles: quantitative assessment of silicone oil release with drugs used for intravitreal injection (2021) (3)
- Fundamental differences in the interactions of stabilizing solutes with proteins during freeze-thawing versus during freeze-drying☆ (1988) (3)
- Compatibility of medications with intravenous lipid emulsions: Effects of simulated Y-site mixing. (2020) (3)
- Abstract of papers presented at the Twenty-Fifth Annual Meeting of the Society for Cryobiology July 11–15, 1988, Aachen, West Germany Symposium III—Cold tolerance and resistance: What can we learn from nature?Interactions of natural cryoprotectants with membranes and proteins☆☆☆ (1988) (2)
- Real-Time Infrared Spectroscopic Analysis of Lysozyme During Lyophilization. Structure-Hydration Behavior and Influence of Sucrose. (1995) (2)
- The Role of Platelets in Chilling‐Induced Injury a (1994) (2)
- Value that industrial collaborations bring to research and education efforts in universities: perspective of a professor working in the field of development of therapeutic proteins (2013) (2)
- High particle variability across siliconized and oil-free syringes and needles from the same lots (2021) (2)
- Meeting biopharmaceutical analytical requirements for subvisible particle sizing and counting (2015) (2)
- Effects of transportation of IV bags containing protein formulations via hospital pneumatic tube system: Particle characterization by multiple methods. (2022) (2)
- Investigation of the Immunogenicity of Different Types of Aggregates of a Murine Monoclonal Antibody in Mice (2014) (1)
- Subvisible Particles in Solutions of Remicade in Intravenous Saline Activate Immune System Pathways in In Vitro Human Cell Systems. (2021) (1)
- Correction to Conformational Properties of Nine Purified Cystathionine β-Synthase Mutants. (2012) (1)
- A method of producing an immunologically active adjuvansbundet dried vaccine composition (2008) (1)
- Working to improve healthcare for people in developing countries. (2008) (1)
- Application of the preferential exclusion mechanism to preservation of proteins and phospholipid bilayers (1989) (1)
- The effects of external salinity on carbon dioxide incorporation into free amino acids in Artemia nauplii (1981) (1)
- Simulated Y-site compatibility of Medications with concentrated Neonatal and Pediatric Parenteral Nutrition: A drug compatibility study. (2022) (1)
- Quantitative assessment of silicone oil release with siliconized and silicone oil-free syringes by microflow imaging microscopy. (2022) (1)
- A Discussion of Limitations on the Use of Polymers for Stabilization of Proteins During the Freezing Portion of Lyophilization (1997) (1)
- Chemical-gas sterilization of external surface of polymer-based prefilled syringes and its effect on stability of model therapeutic protein. (2021) (0)
- formulations with high concentration of protein and manufacturing process (2002) (0)
- Temperature-dependent influence of solutes on biomolecules How compatible cryoprotectants become cytotoxic at high temperature (1992) (0)
- Protein Aggregation during Ultrasonic Nebulization (2012) (0)
- In-vitro assessment of release of silicone oil droplets with the use of variety of syringes and needles used in intravitreal injections (2021) (0)
- A 11 Patent Number : 45 Date of Patent : 5 , 171 , 660 Dec . 15 , 1992 Biological Skin Equivalents Permitting Massive Expan sion (2017) (0)
- In Vivo Fluorescence Imaging of IgG1 Aggregates After Subcutaneous and Intravenous Injection in Mice (2013) (0)
- Exploring the protein stabilizing capability of surfactants against agitation stress and the underlying mechanisms. (2022) (0)
- Effects of Lyophilization on Metabolic Integrity of Red Blood Cells. (1994) (0)
- Improved proteindisaggregering and refolding under pressure (2001) (0)
- Physical Compatibility of Y-site Pediatric Drug Administration: A Call for Question of US Pharmacopeia Standards. (2023) (0)
- Corrigendum to: Compatibility of medications with intravenous lipid emulsions: Effects of simulated Y-site mixing. (2022) (0)
- Journal of Pharmaceutical Sciences. Editorial. (2012) (0)
- Stability of Human Serum Albumin plasma by varying the pH and adding ethanol , in what is now During Bioprocessing : Denaturation (0)
- Cellular and Tissue Injury during Nonfreezing Cold Injury and Frostbite (1991) (0)
- Improved decay and refolding of proteins using high pressure (2001) (0)
- Studies on the Chaperone-Like Activity of Human Aldehyde Dehydrogenase 3a1 (2003) (0)
- Micro- And Nanoparticles Delivered in Intravenous Saline and in an Intravenous Solution of a Therapeutic Antibody Product (2017) (0)
- On temperature-responsive gel for sustained release of protein drug substances (1997) (0)
- temperature sensitive for sustained drug delivery protein-based gel. (1997) (0)
- Photo-Oxidative Damage to the Corneal Crystallin ALDH3A1: Structural and Functional Consequences of Direct UV Absorption (2008) (0)
- Mechanism of interaction of amino acids with phospholipid membranes during freezing (1988) (0)
- A process for the preparation of tissues for transplantation (1992) (0)
- Biochemical and Biophysical Characterization of UV-Exposed Human ALDH3A1 (2002) (0)
- Value that industrial collaborations bring to research and education efforts in universities: perspective of a professor working in the field of development of therapeutic proteins (2013) (0)
- Effects of cryoprotectants on phospholipid bilayers at high temperatures (1989) (0)
- Effects of Excipients on the Chemical and Physical Stability of Glucagon during Freeze-Drying and Storage in Dried Formulations (2012) (0)
- Höjtryksrefoldning of protein aggregates and inclusion bodies (1999) (0)
- Calorimetric determination of inhibition of ice (2005) (0)
- Cryoprotectants in the hemolymph of the intertidal bivalve, Mytilus edulis (1987) (0)
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