John Diffley
#109,887
Most Influential Person Now
Molecular biologist
John Diffley 's AcademicInfluence.com Rankings
John Diffley biology Degrees
Biology
#6438
World Rank
#9150
Historical Rank
#2070
USA Rank
Molecular Biology
#988
World Rank
#1012
Historical Rank
#197
USA Rank
Download Badge
Biology
John Diffley 's Degrees
- Bachelors Biology University of California, Berkeley
- PhD Molecular Biology Stanford University
Similar Degrees You Can Earn
Why Is John Diffley Influential?
(Suggest an Edit or Addition)According to Wikipedia, John Francis Xavier Diffley is an American biochemist and Associate Research Director at the Francis Crick Institute. He is known for his contributions to the understanding of how DNA replication is initiated, and how it is subsequently regulated throughout the cell cycle and in response to DNA damage.
John Diffley 's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication (1998) (695)
- Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint (2001) (690)
- Uninterrupted MCM2-7 function required for DNA replication fork progression. (2000) (673)
- Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing (2009) (623)
- Two steps in the assembly of complexes at yeast replication origins in vivo (1994) (594)
- Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. (1997) (536)
- Mrc1 transduces signals of DNA replication stress to activate Rad53 (2001) (534)
- Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast (2007) (522)
- Regulation of Early Events in Chromosome Replication (2004) (433)
- Regulated Eukaryotic DNA Replication Origin Firing with Purified Proteins (2015) (424)
- A central role for DNA replication forks in checkpoint activation and response. (2003) (417)
- S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state (1995) (394)
- An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast (1996) (376)
- Protein-DNA interactions at a yeast replication origin (1992) (361)
- CDKs Promote DNA Replication Origin Licensing in Human Cells by Protecting Cdc6 from APC/C-Dependent Proteolysis (2005) (354)
- Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast. (1996) (321)
- The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast (1997) (320)
- The Cdc7 protein kinase is required for origin firing during S phase. (1998) (315)
- Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2–7 during G1 phase (2002) (307)
- DNA Replication and Oncogene-Induced Replicative Stress (2014) (281)
- Checkpoint Dependent Inhibition of DNA Replication Initiation by Sld3 and Dbf4 Phosphorylation (2010) (274)
- Once and only once upon a time: specifying and regulating origins of DNA replication in eukaryotic cells. (1996) (255)
- How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication (2017) (254)
- Eukaryotic DNA replication control: lock and load, then fire. (2009) (250)
- A close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria. (1991) (247)
- Yeast origin recognition complex is involved in DNA replication and transcriptional silencing (1993) (233)
- G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus (1999) (229)
- Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo. (1994) (224)
- Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein–Barr virus (2001) (222)
- Regulating DNA replication in eukarya. (2013) (222)
- Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders. (1998) (222)
- Visualization of Altered Replication Dynamics after DNA Damage in Human Cells* (2004) (220)
- Break dosage, cell cycle stage and DNA replication influence DNA double strand break response (2008) (217)
- DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p (2000) (209)
- The cyclin-dependent kinase Cdc28p regulates distinct modes of Cdc6p proteolysis during the budding yeast cell cycle (2000) (208)
- Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC. (1995) (196)
- Chromatin Controls DNA Replication Origin Selection, Lagging-Strand Synthesis, and Replication Fork Rates (2017) (191)
- ATPase-Dependent Quality Control of DNA Replication Origin Licensing (2013) (190)
- Purification of a yeast protein that binds to origins of DNA replication and a transcriptional silencer. (1988) (188)
- ORC‐ and Cdc6‐dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae. (1996) (181)
- Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks. (2008) (175)
- Deregulated G1-cyclin expression induces genomic instability by preventing efficient pre-RC formation. (2002) (174)
- Is the MCM2-7 complex the eukaryotic DNA replication fork helicase? (2001) (171)
- DNA binding properties of an HMG1-related protein from yeast mitochondria. (1992) (164)
- The mechanism of eukaryotic CMG helicase activation (2018) (160)
- Activation of dormant origins of DNA replication in budding yeast. (1999) (158)
- Positive Supercoiling of Mitotic DNA Drives Decatenation by Topoisomerase II in Eukaryotes (2011) (154)
- Similarity between the transcriptional silencer binding proteins ABF1 and RAP1. (1989) (153)
- MCM2-7 proteins are essential components of prereplicative complexes that accumulate cooperatively in the nucleus during G1-phase and are required to establish, but not maintain, the S-phase checkpoint. (2001) (150)
- Topoisomerase II inactivation prevents the completion of DNA replication in budding yeast. (2008) (146)
- Regulation of DNA Replication through Sld3-Dpb11 Interaction Is Conserved from Yeast to Humans (2011) (143)
- DNA replication as a target of the DNA damage checkpoint. (2009) (137)
- The chromosome replication cycle. (2002) (135)
- Role of DNA Replication Proteins in Double-Strand Break-Induced Recombination in Saccharomyces cerevisiae (2004) (134)
- Dbf4p, an Essential S Phase-Promoting Factor, Is Targeted for Degradation by the Anaphase-Promoting Complex (2000) (134)
- CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis. (2000) (131)
- MCM: one ring to rule them all. (2016) (129)
- Controlling DNA replication origins in response to DNA damage – inhibit globally, activate locally (2013) (128)
- Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control (2004) (120)
- Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment (2011) (118)
- DNA replication: Building the perfect switch (2001) (111)
- Separate SCFCDC4 recognition elements target Cdc6 for proteolysis in S phase and mitosis (2001) (109)
- Stepwise assembly of initiation proteins at budding yeast replication origins in vitro. (2000) (107)
- Origin Licensing Requires ATP Binding and Hydrolysis by the MCM Replicative Helicase (2014) (104)
- Quality control in the initiation of eukaryotic DNA replication (2011) (102)
- Phosphopeptide binding by Sld3 links Dbf4‐dependent kinase to MCM replicative helicase activation (2016) (102)
- Activation of the replicative DNA helicase: breaking up is hard to do. (2012) (88)
- Identification of a Heteromeric Complex That Promotes DNA Replication Origin Firing in Human Cells (2013) (82)
- Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading (2017) (82)
- Prereplicative complexes assembled in vitro support origin-dependent and independent DNA replication (2014) (79)
- Homology explains the functional similarities of Treslin/Ticrr and Sld3 (2010) (79)
- CMG–Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome (2017) (76)
- Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM (2019) (72)
- The initiation of chromosomal DNA replication in eukaryotes. (1990) (71)
- Evidence for a Cdc6p‐independent mitotic resetting event involving DNA polymerase α (1998) (70)
- Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome (2018) (69)
- Cryo-EM structure of a licensed DNA replication origin (2017) (62)
- Reconstitution of an efficient thymidine salvage pathway in Saccharomyces cerevisiae. (2003) (61)
- Protein-DNA interactions in the epsilon-globin gene silencer. (1993) (60)
- Recent developments in the initiation of chromosomal DNA replication: a complex picture emerges. (1994) (56)
- Cdt1 stabilizes an open MCM ring for helicase loading (2017) (55)
- Transcriptional silencing and lamins (1989) (54)
- Interaction of a nuclear factor with the polyomavirus enhancer region. (1986) (53)
- Mutational analysis of conserved sequence motifs in the budding yeast Cdc6 protein. (2001) (51)
- Recruitment of Mcm10 to Sites of Replication Initiation Requires Direct Binding to the Minichromosome Maintenance (MCM) Complex* (2015) (50)
- A close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria (1991) (49)
- Replication control: Choreographing replication origins (1998) (47)
- DNA Replication and Oncogene-Induced Replicative Stress (2014) (43)
- Stepwise assembly of initiation complexes at budding yeast replication origins during the cell cycle (1995) (43)
- Global effects of DNA replication and DNA replication origin activity on eukaryotic gene expression (2009) (42)
- The many faces of redundancy in DNA replication control. (2010) (38)
- Factors Affecting the Diversity of DNA Replication Licensing Control in Eukaryotes (2009) (38)
- Mechanisms involved in regulating DNA replication origins during the cell cycle and in response to DNA damage. (2004) (32)
- Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease (2021) (31)
- Replication Timing: The Early Bird Catches the Worm (2012) (28)
- Affinity labeling the DNA polymerase alpha complex. I. Pyridoxal 5'-phosphate inhibition of DNA polymerase and DNA primase activities of the DNA polymerase alpha complex from Drosophila melanogaster embryos. (1988) (27)
- Purification of a cellular, double-stranded DNA-binding protein required for initiation of adenovirus DNA replication by using a rapid filter-binding assay (1986) (27)
- Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase (2021) (23)
- Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase (2021) (23)
- Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease (2021) (23)
- The initiation of DNA replication in the budding yeast cell division cycle (1995) (21)
- Early events in eukaryotic DNA replication. (1992) (21)
- Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease (2021) (20)
- Lessons in how to hold a fork (2003) (19)
- Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase (2021) (17)
- Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation (2021) (16)
- Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease (2021) (16)
- Checkpoint-dependent RNR induction promotes fork restart after replicative stress (2015) (15)
- Eukaryotic DNA replication. (1994) (15)
- Mechanism of replication origin melting nucleated by CMG helicase assembly (2022) (15)
- The Initiation of Eukaryotic DNA Replication. (2022) (13)
- Pre-replicative complex assembly with purified proteins. (2012) (13)
- Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase (2021) (12)
- Coping with and recovering from hydroxyurea-induced replication fork arrest in budding yeast. (2000) (11)
- DNA-Protein Interactions at the Replication Origins of Adenovirus and Sv-40 (1986) (11)
- Budding yeast Rap1, but not telomeric DNA, is inhibitory for multiple stages of DNA replication in vitro (2021) (10)
- DNA replication origins retain mobile licensing proteins (2021) (10)
- Global regulators of chromosome function in yeast (1992) (10)
- Affinity labeling the DNA polymerase alpha complex. Identification of subunits containing the DNA polymerase active site and an important regulatory nucleotide-binding site. (1988) (8)
- Replication origins in eukaroytes. (1996) (8)
- Rpd3L Contributes to the DNA Damage Sensitivity of Saccharomyces cerevisiae Checkpoint Mutants (2018) (8)
- Synchronized maturation and breeding in natural populations ofXiphophorus variatus (Poeciliidae) (1981) (7)
- Identification of SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of the nsp14 RNA Cap Methyltransferase (2021) (6)
- A close relative of the nuclear , chromosomal high-mobility group protein HMG 1 in yeast mitochondria ( Saccharomyces cerevisiael / DNA-binding protein / repicaton / transcwption / HMG box ) (6)
- The eukaryotic replisome requires an additional helicase to disarm dormant replication origins (2020) (5)
- Oncogenes and cell proliferation: Cell cycle, genome integrity and cancer — a millennial view: Editorial overview (2000) (5)
- Genomic footprinting of budding yeast replication origins during the cell cycle. (1997) (5)
- On the road to replication (2016) (5)
- Eukaryotic DNA replication with purified budding yeast proteins. (2021) (4)
- Interactions between Purified Cellular Proteins and Yeast Origins of DNA Replication (1988) (4)
- Multiplex Cell Fate Tracking by Flow Cytometry (2020) (3)
- Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae (2022) (2)
- Author's overview: identifying SARS-CoV-2 antiviral compounds (2021) (2)
- A DNA replication fork-centric view of the budding yeast DNA damage response. (2022) (2)
- An improved method for the incorporation of fluoromethyl ketones into solid phase peptide synthesis techniques (2021) (2)
- A replication fork determinant for the establishment of sister chromatid cohesion (2023) (1)
- ATP Binding and hydrolysis by the Mcm2-7 replicative helicase play distinct roles during origin licensing (2013) (1)
- of DNA replication in eukaryotic cells. Once and only once upon a time: specifying and regulating origins (2011) (1)
- Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14 and Sic1 for origin licensing in S. cerevisiae (2021) (1)
- Unchecked nick ligation can promote localized genome re-replication (2021) (1)
- Crystal structure of yeast Cdt1 C-terminal domain (2017) (1)
- Crystal structure of yeast Cdt1 (N terminal and middle domain), form 1. (2017) (0)
- Crystal structure of yeast Cdt1 middle domain (residues 294-433) (2017) (0)
- Nucleotide binding halts diffusion of the eukaryotic replicative helicase during activation (2022) (0)
- Can a nick promote partial genome re-replication? (2020) (0)
- Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication (2023) (0)
- Electron Microscopic Studies of the Eukaryotic Pre-Replicative Mcm2-7 Complex (2013) (0)
- Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM (2019) (0)
- Origin Binding Proteins from Yeast (1989) (0)
- Early Events in DNA Replication (2012) (0)
- Multiple DNA repair pathways contribute to cell lethality in checkpoint mutants (2005) (0)
- S. cerevisiae MCM double hexamer bound to duplex DNA (2017) (0)
- Faculty Opinions recommendation of Relicensing of transcriptionally inactivated replication origins in budding yeast. (2013) (0)
- Faculty Opinions recommendation of The helicase-like domains of type III restriction enzymes trigger long-range diffusion along DNA. (2013) (0)
- Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences: 354 (1389) (1999) (0)
- ARS Binding Factors from Saccharomyces cerevisiae (1992) (0)
- Characterization of Protein Which Binds Specifically to a Putative Origin of Cellular DNA-Replication (1986) (0)
- Different repair pathways are involved in checkpoint-dependent replication fork stabilization (2006) (0)
- Author response: Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae (2021) (0)
- Mechanism of replication origin melting nucleated by CMG helicase assembly (2022) (0)
- Cryo-EM structure of a licensed DNA replication origin (2017) (0)
- 281 Publications 15,732 Citations See Profile (2009) (0)
- Ars Binding Factors in DNA Replication and Transcriptional Silencing (1990) (0)
- Crystal structure of yeast Cdt1 (N terminal and middle domain), form 2. (2017) (0)
- Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome (2018) (0)
This paper list is powered by the following services:
Other Resources About John Diffley
What Schools Are Affiliated With John Diffley ?
John Diffley is affiliated with the following schools:
