Kenneth Baillie
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Computer Science
Kenneth Baillie's Degrees
- PhD Computer Science Stanford University
- Masters Computer Science University of California, Berkeley
- Bachelors Computer Science University of California, Berkeley
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Why Is Kenneth Baillie Influential?
(Suggest an Edit or Addition)According to Wikipedia, Kenneth Baillie , Professor of Experimental Medicine at the University of Edinburgh, is a medical scientist working in genomics in critical care medicine and respiratory infection. Research Through his work in genomics, he has made several discoveries including finding multiple human genes that are important in critical illness caused by influenza. and COVID-19. He started the GenOMICC study in 2016, to study genetic predisposition to a wide range of severe infections. In 2020 he expanded the study and used it to discover human genes that cause susceptibility to severe Covid-19 This discovery led directly to the finding that a new drug, baricitinib, is an effective treatment for severe Covid-19. He discovered a further 23 genes underlying severe Covid-19 in 2021.
Kenneth Baillie's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report (2020) (4350)
- Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study (2020) (2363)
- An atlas of active enhancers across human cell types and tissues (2014) (2106)
- Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury (2020) (1754)
- A promoter-level mammalian expression atlas (2014) (1664)
- Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial (2020) (1480)
- Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (2021) (1083)
- Effect of Hydroxychloroquine in Hospitalized Patients with COVID-19 (2020) (1040)
- A minimal common outcome measure set for COVID-19 clinical research (2020) (939)
- The Effectiveness of Convalescent Plasma and Hyperimmune Immunoglobulin for the Treatment of Severe Acute Respiratory Infections of Viral Etiology: A Systematic Review and Exploratory Meta-analysis (2014) (927)
- Genetic mechanisms of critical illness in COVID-19 (2020) (887)
- Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19 (2020) (884)
- Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19 (2020) (884)
- Microglial brain region-dependent diversity and selective regional sensitivities to ageing (2015) (755)
- IFITM3 restricts the morbidity and mortality associated with influenza (2012) (680)
- Somatic retrotransposition alters the genetic landscape of the human brain (2011) (647)
- Gateways to the FANTOM5 promoter level mammalian expression atlas (2015) (611)
- Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score (2020) (590)
- SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses (2022) (529)
- Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (2020) (516)
- Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells (2015) (502)
- Mapping the human genetic architecture of COVID-19 (2021) (455)
- Mapping the human genetic architecture of COVID-19 (2021) (455)
- Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study (2020) (451)
- Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity (2021) (443)
- Features of 16,749 hospitalised UK patients with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol (2020) (397)
- Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial (2021) (351)
- Endogenous Retrotransposition Activates Oncogenic Pathways in Hepatocellular Carcinoma (2013) (344)
- Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison (2020) (331)
- State of Knowledge and Data Gaps of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Humans (2013) (326)
- Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (2021) (316)
- Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): preliminary results of a randomised, controlled, open-label, platform trial (2021) (282)
- Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages (2012) (278)
- The 2018 Lake Louise Acute Mountain Sickness Score. (2018) (252)
- An expression atlas of human primary cells: inference of gene function from coexpression networks (2013) (249)
- Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel (2020) (218)
- Middle East Respiratory Syndrome. (2017) (211)
- Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study (2021) (201)
- Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study (2021) (201)
- Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (2021) (201)
- Tissue-Specific Immunopathology in Fatal COVID-19 (2020) (198)
- A gene expression atlas of the domestic pig (2012) (169)
- Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol (2021) (165)
- Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (2021) (162)
- FANTOM5 CAGE profiles of human and mouse samples (2017) (153)
- Antiviral combinations for severe influenza (2014) (148)
- Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Trial. (2022) (143)
- The transcription factor YY1 binds to negative regulatory elements in the human cytomegalovirus major immediate early enhancer/promoter and mediates repression in non-permissive cells (1994) (139)
- Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19 (2021) (136)
- Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study (2021) (136)
- Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease. An International Multicenter Study (2020) (132)
- Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients (2020) (120)
- Whole-genome sequencing reveals host factors underlying critical COVID-19 (2022) (120)
- Outcomes of COVID-19 related hospitalization among people with HIV in the ISARIC WHO Clinical Characterization Protocol (UK): a prospective observational study. (2020) (119)
- Colchicine in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (2021) (116)
- A blood atlas of COVID-19 defines hallmarks of disease severity and specificity (2021) (112)
- Oral antioxidant supplementation does not prevent acute mountain sickness: double blind, randomized placebo-controlled trial. (2009) (110)
- Spineless: status and trends of the world's invertebrates (2012) (106)
- The Role of Host Genetics in Susceptibility to Influenza: A Systematic Review (2012) (106)
- Repression of human cytomegalovirus major immediate early gene expression in a monocytic cell line. (1992) (106)
- Evaluation of antibody testing for SARS-Cov-2 using ELISA and lateral flow immunoassays (2020) (104)
- The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity (2020) (103)
- The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases: A systematic review and meta-analysis (2019) (103)
- Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populations. (2010) (100)
- Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study (2021) (98)
- Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study (2021) (98)
- Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection (2020) (95)
- Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK (2021) (94)
- Functional clustering and lineage markers: insights into cellular differentiation and gene function from large-scale microarray studies of purified primary cell populations. (2010) (94)
- Functional annotation of human long noncoding RNAs via molecular phenotyping (2019) (91)
- Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease (2017) (88)
- Ethnicity and Outcomes from COVID-19: The ISARIC CCP-UK Prospective Observational Cohort Study of Hospitalised Patients (2020) (84)
- Endogenous urate production augments plasma antioxidant capacity in healthy lowland subjects exposed to high altitude. (2007) (82)
- Evolution Lost: status and trends of the world's vertebrates (2010) (82)
- Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis (2022) (80)
- Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses (2021) (80)
- SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses (2022) (80)
- Open source clinical science for emerging infections (2013) (80)
- Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study (2021) (77)
- A prenylated dsRNA sensor protects against severe COVID-19 (2021) (76)
- Edinburgh Research Explorer Features of 20133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study (2020) (72)
- Human Cytomegalovirus Infection Inhibits Tumor Necrosis Factor Alpha (TNF-α) Signaling by Targeting the 55-Kilodalton TNF-α Receptor (2003) (72)
- Outcomes of Coronavirus Disease 2019 (COVID-19) Related Hospitalization Among People With Human Immunodeficiency Virus (HIV) in the ISARIC World Health Organization (WHO) Clinical Characterization Protocol (UK): A Prospective Observational Study (2020) (69)
- The Living Planet Index (2017) (69)
- Expression of mesenchyme‐specific gene signatures by follicular dendritic cells: insights from the meta‐analysis of microarray data from multiple mouse cell populations (2011) (63)
- Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19 (2020) (63)
- Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020 (2020) (60)
- Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020 (2020) (60)
- Modelling mutational and selection pressures on dinucleotides in eukaryotic phyla –selection against CpG and UpA in cytoplasmically expressed RNA and in RNA viruses (2013) (59)
- Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals (2021) (59)
- The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis (2015) (58)
- The 21bp repeat element of the human cytomegalovirus major immediate early enhancer is a negative regulator of gene expression in undifferentiated cells. (1991) (58)
- Human cytomegalovirus mediates cell cycle progression through G(1) into early S phase in terminally differentiated cells. (2000) (57)
- Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK (2021) (56)
- Host susceptibility to severe influenza A virus infection (2019) (56)
- SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus (2020) (56)
- Physical, cognitive and mental health impacts of COVID-19 following hospitalisation: a multi-centre prospective cohort study (2021) (56)
- Incidence and predictors of acute mountain sickness among trekkers on Mount Kilimanjaro. (2010) (53)
- Redefining critical illness (2022) (52)
- The mechanism of action of gabapentin in neuropathic pain. (2006) (52)
- Network Analysis Reveals Distinct Clinical Syndromes Underlying Acute Mountain Sickness (2013) (52)
- Influenza--time to target the host? (2013) (51)
- International Severe Acute Respiratory and emerging Infections Consortium Partners^ (2016) (51)
- Human cytomegalovirus infection inhibits tumor necrosis factor alpha (TNF-alpha) signaling by targeting the 55-kilodalton TNF-alpha receptor. (2003) (49)
- COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study (2021) (49)
- Hospital-acquired SARS-CoV-2 infection in the UK's first COVID-19 pandemic wave (2021) (49)
- Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial (2021) (48)
- Neutralising antibodies to SARS coronavirus 2 in Scottish blood donors - a pilot study of the value of serology to determine population exposure (2020) (48)
- Shared genetic etiology between idiopathic pulmonary fibrosis and COVID-19 severity (2020) (48)
- A haemagglutination test for rapid detection of antibodies to SARS-CoV-2 (2020) (47)
- Heteroresistance at the Single-Cell Level: Adapting to Antibiotic Stress through a Population-Based Strategy and Growth-Controlled Interphenotypic Coordination (2014) (47)
- SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus. (2020) (47)
- An updated systematic review of the role of host genetics in susceptibility to influenza (2013) (46)
- Sepsis Subclasses: A Framework for Development and Interpretation. (2021) (45)
- Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19 (2022) (44)
- Human cytomegalovirus infection inhibits epidermal growth factor (EGF) signalling by targeting EGF receptors. (2002) (43)
- Tissue-specific tolerance in fatal Covid-19 (2020) (43)
- Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study (2021) (42)
- Change in plasma vascular endothelial growth factor during onset and recovery from acute mountain sickness. (2007) (41)
- What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? A harmonised, global longitudinal observational study protocol (2020) (39)
- Treatable traits and therapeutic targets: Goals for systems biology in infectious disease (2017) (39)
- An adaptive randomized controlled trial of non-invasive respiratory strategies in acute respiratory failure patients with COVID-19 (2021) (38)
- Transcriptional profiling of the human fibrillin/LTBP gene family, key regulators of mesenchymal cell functions (2014) (36)
- SARS-CoV-2 RNA detected in blood samples from patients with COVID-19 is not associated with infectious virus (2020) (36)
- RECOVERY- Respiratory Support: Respiratory Strategies for patients with suspected or proven COVID-19 respiratory failure; Continuous Positive Airway Pressure, High-flow Nasal Oxygen, and standard care: A structured summary of a study protocol for a randomised controlled trial (2020) (35)
- Research priorities for Long Covid: refined through an international multi-stakeholder forum (2021) (34)
- The effect of dexmedetomidine and clonidine on the inflammatory response in critical illness: a systematic review of animal and human studies (2019) (33)
- Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism (2020) (33)
- Sildenafil citrate for the prevention of high altitude hypoxic pulmonary hypertension: double blind, randomized, placebo-controlled trial. (2011) (33)
- Targeting the host immune response to fight infection (2014) (32)
- High altitude adaptation in Daghestani populations from the Caucasus (2011) (31)
- Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID‐19: Analysis of the ISARIC CCP‐UK Cohort (2021) (31)
- Sustainable Design Futures: An open design vision for the circular economy in fashion and textiles (2017) (30)
- Contamination of anaesthetic machines with pathogenic organisms * (2007) (30)
- An evidence-based framework for priority clinical research questions for COVID-19 (2020) (28)
- Global outbreak research: harmony not hegemony (2020) (28)
- Dynamic data-driven meta-analysis for prioritisation of host genes implicated in COVID-19 (2020) (27)
- Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses (2021) (27)
- Human cytomegalovirus modulation of CCR5 expression on myeloid cells affects susceptibility to human immunodeficiency virus type 1 infection. (2006) (26)
- Drotrecogin alfa (activated) in severe sepsis. (2006) (25)
- NT-proBNP does not rise on acute ascent to high altitude. (2008) (24)
- Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study (2021) (23)
- Wide variation and systematic bias in expert clinicians’ perceptions of prognosis following brain injury (2013) (22)
- Identification of Novel Genes Selectively Expressed in the Follicle-Associated Epithelium from the Meta-Analysis of Transcriptomics Data from Multiple Mouse Cell and Tissue Populations (2012) (22)
- Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (2018) (21)
- A common TMPRSS2 variant has a protective effect against severe COVID-19 (2022) (21)
- Thromboelastometry and Platelet Function during Acclimatization to High Altitude (2018) (21)
- Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection (2020) (21)
- Outcomes of COVID-19 related hospitalisation among people with HIV in the ISARIC WHO Clinical Characterisation Protocol UK Protocol: prospective observational study (2020) (20)
- Adeno-associated virus 2 infection in children with non-A-E hepatitis (2022) (20)
- Circulating histones play a central role in COVID-19-associated coagulopathy and mortality (2021) (20)
- Obesity, chronic disease, age, and in-hospital mortality in patients with covid-19: analysis of ISARIC clinical characterisation protocol UK cohort (2021) (19)
- Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID) (2021) (19)
- Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits (2020) (19)
- Endomembrane targeting of human OAS1 p46 augments antiviral activity (2021) (19)
- High Altitude Pulmonary Oedema (2011) (18)
- Ebola virus antibody decay–stimulation in a high proportion of survivors (2021) (18)
- Using imaging to combat a pandemic: rationale for developing the UK National COVID-19 Chest Imaging Database (2020) (18)
- Endothelial nitric oxide synthase polymorphisms do not influence pulmonary artery systolic pressure at altitude. (2006) (18)
- Phosphodiesterase type 5 inhibitors in the treatment and prevention of high altitude pulmonary edema. (2007) (18)
- Co-Infections, Secondary Infections, and Antimicrobial Usage in Hospitalised Patients with COVID-19 from the ISARIC WHO CCP-UK Study: A Prospective, Multicentre Cohort Study (2021) (17)
- The value of open-source clinical science in pandemic response: lessons from ISARIC (2021) (17)
- Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation (2021) (17)
- Robust, reproducible clinical patterns in hospitalised patients with COVID-19 (2020) (17)
- SARS-CoV-2 environmental contamination from hospitalised patients with COVID-19 receiving aerosol-generating procedures (2021) (17)
- 1670O Prospective data of first 1,797 hospitalised patients with cancer and COVID-19 derived from the COVID-19 Clinical Information Network and international Severe Acute Respiratory and emerging Infections Consortium, WHO Coronavirus Clinical Characterisation Consortium (2020) (17)
- Molecular Patterns in Acute Pancreatitis Reflect Generalizable Endotypes of the Host Response to Systemic Injury in Humans (2020) (16)
- Is somatic retrotransposition a parasitic or symbiotic phenomenon? (2011) (16)
- Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity (2021) (16)
- Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (2019) (15)
- Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative (2022) (15)
- Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial. (2022) (15)
- COVID-19 pneumothorax in the UK: a prospective observational study using the ISARIC WHO clinical characterisation protocol (2021) (14)
- The Search for Efficacious New Therapies in Sepsis Needs to Embrace Heterogeneity (2019) (14)
- Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease (2018) (14)
- Combined Mesenchymal Stromal Cell Therapy and Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome. A Randomized Controlled Trial in Sheep (2020) (14)
- Prospective validation of the 4C prognostic models for adults hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol (2021) (14)
- Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England (2021) (14)
- Morphine, gabapentin, or their combination for neuropathic pain. (2005) (13)
- Tissue Proteomic Analysis Identifies Mechanisms and Stages of Immunopathology in Fatal COVID-19 (2021) (13)
- ISARIC Clinical Data Report issued: 14 July 2021 (2020) (12)
- Retinal vessel tortuosity in response to hypobaric hypoxia. (2012) (11)
- Azithromycin in Hospitalised Patients with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (2020) (11)
- Whole genome sequencing identifies multiple loci for critical illness caused by COVID-19 (2021) (11)
- Negative regulation of ACE2 by interferons in vivo and its genetic control (2020) (10)
- A catalog of associations between rare coding variants and COVID-19 outcomes (2020) (10)
- Outcome of hospitalisation for COVID-19 in patients with Interstitial Lung Disease: An international multicentre study. (2020) (10)
- Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study (2022) (10)
- Hypoxia Modulates Platelet Purinergic Signalling Pathways (2019) (10)
- Changes in UK hospital mortality in the first wave of COVID-19: the ISARIC WHO Clinical Characterisation Protocol prospective multicentre observational cohort study (2020) (10)
- The Living Planet Index: guidance for national and regional use (2009) (10)
- Evaluation of the effectiveness of remdesivir in treating severe COVID-19 using data from the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, national cohort study. (2021) (9)
- Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19 (2021) (9)
- Pericardial effusions in healthy lowlanders after acute ascent to high altitude (2005) (9)
- Development and validation of the 4C Deterioration model for adults hospitalised with COVID-19 (2020) (9)
- Elevated antiviral, myeloid and endothelial inflammatory markers in severe COVID-19 (2020) (9)
- Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation (2022) (8)
- Genetic Landscape of the ACE2 Coronavirus Receptor (2022) (8)
- Cancer datasets and the SARS-CoV-2 pandemic: establishing principles for collaboration (2020) (8)
- Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission (2022) (8)
- Simple, easily memorised “rules of thumb” for the rapid assessment of physiological compensation for respiratory acid-base disorders (2008) (8)
- Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19 (2021) (8)
- Rapid selection of P323L in the SARS-CoV-2 polymerase (NSP12) in humans and non-human primate models and confers a large plaque phenotype (2021) (8)
- Combined Mesenchymal Stromal Cell Therapy and ECMO in ARDS: A Controlled Experimental Study in Sheep. (2020) (8)
- Activated protein C: controversy and hope in the treatment of sepsis. (2007) (7)
- Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study (2022) (7)
- Comparison of children and young people admitted with SARS-CoV-2 across the UK in the first and second pandemic waves: prospective multicentre observational cohort study (2021) (7)
- The citric acid cough threshold and the ventilatory response to carbon dioxide on ascent to high altitude. (2009) (7)
- Comparison of UK paediatric SARS-CoV-2 admissions across the first and second pandemic waves (2022) (7)
- ISARIC COVID-19 Clinical Data Report: 8 June 2020 (2020) (7)
- Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study (2022) (7)
- Characterizing preclinical sub‐phenotypic models of acute respiratory distress syndrome: An experimental ovine study (2021) (7)
- Tracking Change in Abundance: The Living Planet Index (2013) (7)
- Developing Novel Host-Based Therapies Targeting Microbicidal Responses in Macrophages and Neutrophils to Combat Bacterial Antimicrobial Resistance (2020) (7)
- Clinical characteristics of children and young people hospitalised with covid-19 in the United Kingdom: prospective multicentre observational cohort study (2020) (6)
- A gene locus that controls expression of ACE2 in virus infection (2020) (6)
- Comprehensive Characterization of Transcriptional Activity during Influenza A Virus Infection Reveals Biases in Cap-Snatching of Host RNA Sequences (2020) (6)
- 2010 & beyond: Rising to the biodiversity challenge (2008) (6)
- Deciding authorship order (2013) (6)
- Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients (2022) (6)
- Detection and quantification of antibody to SARS CoV 2 receptor binding domain provides enhanced sensitivity, specificity and utility (2022) (6)
- SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination (2022) (6)
- Cycle threshold values are inversely associated with poorer outcomes in hospitalized patients with COVID-19: a prospective, observational cohort study conducted at a UK tertiary hospital (2021) (5)
- Predictive validity of a novel non-invasive estimation of effective shunt fraction in critically ill patients (2019) (5)
- Multiomic analysis reveals cell-type-specific molecular determinants of COVID-19 severity (2022) (5)
- Multiomic definition of generalizable endotypes in human acute pancreatitis (2019) (5)
- Secreted SARS-CoV-2 ORF8 modulates the cytokine expression profile of human macrophages (2021) (5)
- Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study (2021) (5)
- In Pursuit of Precision Medicine in the Critically Ill (2018) (5)
- A Genome-Wide CRISPR/Cas9 Screen Reveals the Requirement of Host Sphingomyelin Synthase 1 for Infection with Pseudorabies Virus Mutant gD–Pass (2021) (5)
- Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases (2020) (5)
- Sequence analysis of SARS-CoV-2 in nasopharyngeal samples from patients with COVID-19 illustrates population variation and diverse phenotypes, placing the in vitro growth properties of B.1.1.7 and B.1.351 lineage viruses in context (2021) (4)
- Variation in ERAP2 has opposing effects on severe respiratory infection and autoimmune disease (2022) (4)
- Global infectious disease research collaborations in crises: building capacity and inclusivity through cooperation (2021) (4)
- Recovery from Covid-19 critical illness: a secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial (2021) (4)
- Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers (2022) (4)
- Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages (2022) (4)
- Towards nationally curated data archives for clinical radiology image analysis at scale: Learnings from national data collection in response to a pandemic (2021) (4)
- Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease (2016) (4)
- Subtractive CRISPR screen identifies factors involved in non-canonical LC3 lipidation (2020) (4)
- Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: Findings from a Mendelian randomisation study (2022) (4)
- Proteome-by-phenome Mendelian Randomisation detects 38 proteins with causal roles in human diseases and traits (2019) (4)
- GWAS and meta-analysis identifies multiple new genetic mechanisms underlying severe Covid-19. (2022) (4)
- Systematic review and meta-analysis identifies potential host therapeutic targets in COVID-19. (2020) (3)
- Admission Blood Glucose Level and Its Association With Cardiovascular and Renal Complications in Patients Hospitalized With COVID-19. (2022) (3)
- Residual Lung Abnormalities after COVID-19 Hospitalization: Interim Analysis of the UKILD Post–COVID-19 Study (2022) (3)
- Comorbidities, multimorbidity and COVID-19 (2023) (3)
- LBA60 Prospective data of >20,000 hospitalised patients with cancer and COVID-19 derived from the International Severe Acute Respiratory and emerging Infections Consortium WHO Coronavirus Clinical Characterisation Consortium: CCP-CANCER UK (2021) (3)
- Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID‐19 (2022) (3)
- Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol (2020) (3)
- Explorer IFITM 3 restricts the morbidity and mortality associated with influenza (2016) (3)
- Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19 (2022) (3)
- Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study (2022) (3)
- Human genome meeting 2016 (2016) (3)
- SARS-CoV-2 environmental contamination from hospitalised COVID-19 patients receiving aerosol generating procedures (2021) (3)
- Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (2021) (2)
- Detection and Quantification of Antibody to SARS-CoV-2 Receptor Binding Domain Provides Enhanced Sensitivity, Specificity and Utility (2021) (2)
- Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19. (2023) (2)
- Comparative evaluation of ten lateral flow immunoassays to detect SARS-CoV-2 antibodies (2021) (2)
- Soluble P-Selectin and von Willebrand Factor Rise in Healthy Volunteers Following Non-exertional Ascent to High Altitude (2022) (2)
- Systematic comparison of ranking aggregation methods for gene lists in experimental results (2022) (2)
- Early short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis (2022) (2)
- An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients (2022) (2)
- Impact of Dexamethasone and Remdesivir on Neurological Complications during COVID-19 (2022) (2)
- The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome (2015) (2)
- Stratified infection medicine: a call to arms. (2014) (2)
- An expression atlas of human primary cells: inference of gene function from coexpression networks (2013) (1)
- A gene expression atlas of the domestic pig (2012) (1)
- of Birmingham Features of 20133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol (2020) (1)
- The V-ATPase complex regulates non-canonical Atg8-family protein lipidation through ATG16L1 recruitment (2022) (1)
- SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus [version 2; peer review: 1 approved] (2020) (1)
- Erratum to: Thromboelastometry and platelet function during acclimatisation to high altitude (2018) (1)
- Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A Mendelian randomisation study (2023) (1)
- Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study (2023) (1)
- Cystatin C is associated with adverse COVID-19 outcomes in diverse populations (2022) (1)
- CO-CONNECT: A hybrid architecture to facilitate rapid discovery and access to UK wide data in the response to the COVID-19 pandemic. (2022) (1)
- Upstream translation initiation expands the coding capacity of segmented negative-strand RNA viruses (2019) (1)
- Symptom‐based case definitions for COVID‐19: Time and geographical variations for detection at hospital admission among 260,000 patients (2022) (1)
- Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial (2023) (1)
- Identification and quantification of SARS-CoV-2 leader subgenomic mRNA gene junctions in nasopharyngeal samples shows phasic transcription in animal models of COVID-19 and dysregulation at later time points that can also be identified in humans (2021) (1)
- In vivo negative regulation of SARS-CoV-2 receptor, ACE2, by interferons and its genetic control (2021) (1)
- Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study (2022) (1)
- Fewer COVID‐19 Neurological Complications with Dexamethasone and Remdesivir (2022) (1)
- Modelling mutational and selection pressures on dinucleotides in eukaryotic phyla –selection against CpG and UpA in cytoplasmically expressed RNA and in RNA viruses (2013) (1)
- Higher dose corticosteroids in hospitalised COVID-19 patients with hypoxia but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial (2022) (1)
- Pandemic, Epidemic, Endemic: B Cell Repertoire Analysis Reveals Unique Anti-Viral Responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus (2021) (1)
- RCT Abstract - An adaptive randomized controlled trial of non-invasive respiratory strategies in acute respiratory failure patients with COVID-19 (2021) (1)
- Two Key Takeaways From a Year of Pandemic Research (2021) (1)
- Genomic investigations of unexplained acute hepatitis in children. (2023) (1)
- Combined MSC therapy and ECMO in experimental ARDS (2020) (1)
- Evaluation of S/F94 as a proxy for COVID-19 severity (2022) (1)
- Comprehensive characterisation of molecular host-pathogen interactions in influenza A virus-infected human macrophages (2019) (1)
- Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity (2021) (0)
- Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity (2021) (0)
- sample information of the human samples (2017) (0)
- Apixaban following discharge in hospitalised adults with COVID-19: Preliminary results from a multicentre, open-label, randomised controlled platform clinical trial. (2022) (0)
- Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study (2023) (0)
- FANTOM5 web resource for the large-scale genome-wide transcription start site activity profiles of wide-range of mammalian cells (2016) (0)
- Characterising pre-clinical sub-phenotypic models of Acute Respiratory Distress Syndrome: an experimental ovine study (2020) (0)
- Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (2023) (0)
- Complete genome sequence of methicillin-sensitive Staphylococcus aureus containing a heterogeneic staphylococcal cassette chromosome element (2013) (0)
- Sepsis: When a Simple Infection Becomes Deadly (2021) (0)
- GenOMICC study - Looking at DNA of patients with severe illness and injury to find the genes that cause some people to become very unwell and be admitted to intensive care (2021) (0)
- Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls (2023) (0)
- Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence (2022) (0)
- SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus. Wellcome Open Research, 5, [181]. (2021) (0)
- Corrigendum: The molecular basis of differential host responses to avian influenza viruses in avian species with differing susceptibility (2023) (0)
- The molecular basis of differential host responses to avian influenza viruses in avian species with differing susceptibility (2023) (0)
- Approaches for elucidating genetic susceptibility to SARS-CoV-2 (2020) (0)
- 260. Corticosteroid treatment in influenza virus and SARS-CoV-2 co-infected patients (2022) (0)
- Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection (2020) (0)
- Human Cytomegalovirus Infection Inhibits Tumor Necrosis Factor Alpha (TNF- (cid:2) ) Signaling by Targeting the 55-Kilodalton TNF- (cid:2) Receptor (2003) (0)
- Author Correction: Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation (2022) (0)
- Whole genome sequencing identifies multiple loci for critical 1 illness caused by COVID-19 2 (2021) (0)
- Complete genome sequence of methicillin-sensitive Staphylococcus aureus containing a heterogeneic staphylococcal cassette chromosome element (2013) (0)
- Heteroresistance at the single-cell level (2017) (0)
- Gateways to the FANTOM5 promoter level mammalian expression atlas (2015) (0)
- SARS-CoV-2 antibody responses associate with sex, age and disease severity in previously uninfected people admitted to hospital with COVID-19: An ISARIC4C prospective study (2023) (0)
- genomic coordinates of the human CAGE peaks (2017) (0)
- Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study (2022) (0)
- Edinburgh Research Explorer Characterization of the domestic goat T cell receptor gene loci and gene usage (2021) (0)
- To the editor [17] (2006) (0)
- expression table of the human CAGE peaks (2017) (0)
- Mechanisms and Stages of Covid-19 Immunopathology Revealed by Tissue-Specific Proteomes (2021) (0)
- Measurement errors caused by incompatibility of apparatus. (2009) (0)
- A Hybrid Architecture (CO-CONNECT) to Facilitate Rapid Discovery and Access to Data Across the United Kingdom in Response to the COVID-19 Pandemic: Development Study (2022) (0)
- Vitamins and Viagra for better performance at high altitude (2017) (0)
- Explorer Middle East Respiratory Syndrome (2017) (0)
- Explorer Host Susceptibility to Severe Influenza A Virus Infection (2019) (0)
- Vector control to eliminate artemisinin resistant malaria in the Greater Mekong subregion (2014) (0)
- Correction to: Predictive validity of a novel non-invasive estimation of effective shunt fraction in critically ill patients (2020) (0)
- Plasma steroid profiles in patients hospitalised with COVID-19 - an ISARIC/WHO CCP-UK cohort study (2021) (0)
- ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19 (2022) (0)
- Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study (2021) (0)
- Letter to the Editor: Response to Luke Fletcher and Philip Peyton regarding “Predictive validity of a novel non-invasive estimation of effective shunt fraction in critically ill patients” (2020) (0)
- Whole genome sequencing reveals host factors underlying critical Covid-19 Accelerated Article Preview (2022) (0)
- 1H NMR Signals from Urine Excreted Protein Are a Source of Bias in Probabilistic Quotient Normalization (2022) (0)
- Predictive validity of effective shunt fraction in critically ill patients (2018) (0)
- EMPLOYER'S LIABILITY AND ERRORS AND OMISSIONS INSURANCE COVERAGE FOR EMPLOYMENT-RELATED CLAIMS (1996) (0)
- University of Birmingham Thromboelastometry and platelet function during acclimatisation to high altitude (2017) (0)
- ReMantle and Make: Feasibility Report for Future Makespaces in RdM (2017) (0)
- Genetic control of KRAB-ZFP genes explains distal CpG-site methylation which associates with human disease phenotypes (2022) (0)
- The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection (2023) (0)
- The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection (2023) (0)
- Viral co-infections in hospitalised COVID-19 patients recruited to the ISARIC WHO CCP-UK study (2022) (0)
- SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus [version 1; peer review: 1 approved with reservations] (2020) (0)
- assay information of the mouse qualitycontrol samples for HeliScopeCAGE (2017) (0)
- High altitude adaptation in Daghestani populations from the Caucasus (2011) (0)
- genomic coordinates of the mouse CAGE peaks (2017) (0)
- Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (2022) (0)
- Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (2022) (0)
- A Living Planet Index for Canada (2007) (0)
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