John Kuriyan
#16,109
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American biochemist
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John Kuriyanbiology Degrees
Biology
#723
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#1262
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Biochemistry
#192
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#242
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Biology
John Kuriyan's Degrees
- Bachelors Chemistry University of California, Berkeley
Why Is John Kuriyan Influential?
(Suggest an Edit or Addition)According to Wikipedia, John Kuriyan is the dean of basic sciences and a professor of biochemistry at Vanderbilt University School of Medicine. He was formerly the Chancellor's Professor at the University of California, Berkeley in the departments of molecular and cell biology and chemistry, a faculty scientist in Berkeley Lab's physical biosciences division, and a Howard Hughes Medical Institute investigator. He is a member of the National Academy of Sciences and he has also been on the Life Sciences jury for the Infosys Prize in 2009, 2019 and 2020.
John Kuriyan's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. (2000) (1774)
- Crystallographic R Factor Refinement by Molecular Dynamics (1987) (1773)
- Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. (2002) (1684)
- The Conformational Plasticity of Protein Kinases (2002) (1592)
- An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor (2006) (1447)
- Crystal structure of the Src family tyrosine kinase Hck (1997) (1136)
- Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571). (2001) (909)
- Molecular dynamics and protein function. (2005) (899)
- Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA (1994) (890)
- Crystallographic Analysis of the Recognition of a Nuclear Localization Signal by the Nuclear Import Factor Karyopherin α (1998) (797)
- Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase (2003) (782)
- Structure of the C-Terminal Region of p21WAF1/CIP1 Complexed with Human PCNA (1996) (777)
- Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1 (1995) (775)
- The structural basis of the activation of Ras by Sos (1998) (728)
- Three-dimensional structure of the β subunit of E. coli DNA polymerase III holoenzyme: A sliding DNA clamp (1992) (710)
- Crystal Structure of a Tyrosine Phosphorylated STAT-1 Dimer Bound to DNA (1998) (707)
- Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide-free forms (1993) (671)
- Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia (2012) (661)
- Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides (1993) (608)
- Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement (1997) (606)
- Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment (2009) (554)
- Modular peptide recognition domains in eukaryotic signaling. (1997) (550)
- Crystal structure of the nucleotide exchange factor GrpE bound to the ATPase domain of the molecular chaperone DnaK. (1997) (483)
- Structural analysis of a eukaryotic sliding DNA clamp–clamp loader complex (2004) (431)
- Crystal Structure of the Conserved Core of HIV-1 Nef Complexed with a Src Family SH3 Domain (1996) (427)
- Architecture and Membrane Interactions of the EGF Receptor (2013) (427)
- Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor (2013) (426)
- A Myristoyl/Phosphotyrosine Switch Regulates c-Abl (2003) (420)
- Crystal Structure of the Cytoplasmic Domain of the Type I TGF β Receptor in Complex with FKBP12 (1999) (419)
- Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. (1999) (407)
- Structural Evidence for Feedback Activation by Ras·GTP of the Ras-Specific Nucleotide Exchange Factor SOS (2003) (397)
- Activation of tyrosine kinases by mutation of the gatekeeper threonine (2008) (384)
- Dynamic Coupling between the SH2 and SH3 Domains of c-Src and Hck Underlies Their Inactivation by C-Terminal Tyrosine Phosphorylation (2001) (383)
- Structures of Src-family tyrosine kinases. (1997) (382)
- The TGF beta receptor activation process: an inhibitor- to substrate-binding switch. (2001) (372)
- Crystal structure of the DsbA protein required for disulphide bond formation in vivo (1993) (371)
- X-ray structure and refinement of carbon-monoxy (Fe II)-myoglobin at 1.5 A resolution. (1986) (365)
- The origin of protein interactions and allostery in colocalization (2007) (356)
- High resolution crystal structure of a paired (Pax) class cooperative homeodomain dimer on DNA (1995) (340)
- Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alpha. (2000) (313)
- Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3 (2009) (313)
- DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2‐terminal domains stabilizes binding of two dimers to tandem DNA sites. (1996) (313)
- Structure of the Autoinhibited Kinase Domain of CaMKII and SAXS Analysis of the Holoenzyme (2005) (310)
- Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization (2012) (302)
- Structural Basis for the Autoinhibition of Calcium/Calmodulin-Dependent Protein Kinase I (1996) (298)
- A Src-Like Inactive Conformation in the Abl Tyrosine Kinase Domain (2006) (290)
- Crystal Structure of the Processivity Clamp Loader Gamma (γ) Complex of E. coli DNA Polymerase III (2001) (284)
- Structural Analysis of Autoinhibition in the Ras Activator Son of Sevenless (2004) (276)
- Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms. (2011) (275)
- Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680. (2006) (274)
- A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV‐1 Nef protein. (1995) (270)
- Structure of the amino-terminal protein interaction domain of STAT-4. (1998) (266)
- The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2 (2011) (264)
- Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity. (2001) (258)
- Mechanism of Processivity Clamp Opening by the Delta Subunit Wrench of the Clamp Loader Complex of E. coli DNA Polymerase III (2001) (249)
- Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases. (2004) (246)
- A conserved protonation-dependent switch controls drug binding in the Abl kinase (2009) (242)
- Molecular mechanisms in signal transduction at the membrane (2010) (239)
- Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk. (1995) (238)
- Inhibition of the EGF Receptor by Binding to an Activating Kinase Domain Interface (2007) (237)
- Crystal Structure of the δ′ Subunit of the Clamp-Loader Complex of E. coli DNA Polymerase III (1997) (236)
- A structural perspective on the regulation of the epidermal growth factor receptor. (2015) (235)
- Sliding clamps of DNA polymerases. (1993) (228)
- Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein (1998) (228)
- Structural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70 (2007) (222)
- Structure of a Sliding Clamp on DNA (2008) (222)
- Membrane-dependent signal integration by the Ras activator Son of sevenless (2008) (217)
- The structure, regulation, and function of ZAP‐70 (2009) (208)
- High yield bacterial expression of active c‐Abl and c‐Src tyrosine kinases (2005) (207)
- A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS (2019) (203)
- Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. (2006) (203)
- A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2+/Calmodulin- Dependent Kinase II Holoenzyme (2011) (202)
- Crystal structure of Escherichia coli thioredoxin reductase refined at 2 A resolution. Implications for a large conformational change during catalysis. (1994) (199)
- c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty. (2007) (198)
- Motors and switches: AAA+ machines within the replisome (2002) (186)
- Crystal structure of a tetradecameric assembly of the association domain of Ca2+/calmodulin-dependent kinase II. (2003) (185)
- Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. (1994) (178)
- Crenolanib is a selective type I pan-FLT3 inhibitor (2014) (176)
- Convergent evolution of similar function in two structurally divergent enzymes (1991) (170)
- Crystal structure of the DNA polymerase processivity factor of T4 bacteriophage. (2000) (169)
- Crystal Structure of the Catalytic α Subunit of E. coli Replicative DNA Polymerase III (2006) (168)
- Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases. (2002) (167)
- Sequence‐specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain (1997) (161)
- How a DNA Polymerase Clamp Loader Opens a Sliding Clamp (2011) (160)
- Effect of anisotropy and anharmonicity on protein crystallographic refinement. An evaluation by molecular dynamics. (1986) (156)
- The Mechanism of ATP-Dependent Primer-Template Recognition by a Clamp Loader Complex (2009) (147)
- Advances in Protein Chemistry and Structural Biology (2010) (147)
- Clamp loaders and sliding clamps. (2002) (141)
- A Ras-induced conformational switch in the Ras activator Son of sevenless (2006) (130)
- Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations. (2009) (127)
- Reciprocal regulation of Hck activity by phosphorylation of Tyr(527) and Tyr(416). Effect of introducing a high affinity intramolecular SH2 ligand. (2000) (118)
- Analysis of the role of PCNA-DNA contacts during clamp loading (2010) (114)
- Regulation of Ras Signaling Dynamics by Sos-Mediated Positive Feedback (2006) (114)
- Structural Basis for the Recognition of c-Src by Its Inactivator Csk (2008) (113)
- Structure-based Mutagenesis Reveals Distinct Functions for Ras Switch 1 and Switch 2 in Sos-catalyzed Guanine Nucleotide Exchange* (2001) (113)
- Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation (2010) (113)
- Molecular basis for multimerization in the activation of the epidermal growth factor receptor (2016) (112)
- Clamp loader structure predicts the architecture of DNA polymerase III holoenzyme and RFC (2001) (109)
- Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics (2014) (107)
- Crystal structure of the processivity clamp loader gamma (gamma) complex of E. coli DNA polymerase III. (2001) (106)
- Rigid protein motion as a model for crystallographic temperature factors. (1991) (104)
- Protein-protein interactions in the allosteric regulation of protein kinases. (2006) (104)
- Exploration of disorder in protein structures by X‐ray restrained molecular dynamics (1991) (101)
- Probing the function of heme distortion in the H-NOX family. (2008) (101)
- Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp (2008) (100)
- Intramolecular Regulatory Interactions in the Src Family Kinase Hck Probed by Mutagenesis of a Conserved Tryptophan Residue* (1998) (100)
- Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II (2006) (98)
- Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT (2018) (97)
- Crystal structure of an archaebacterial DNA polymerase. (1999) (96)
- The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase (2008) (96)
- Regulation of the catalytic activity of the EGF receptor. (2011) (95)
- Modulating heme redox potential through protein-induced porphyrin distortion. (2010) (94)
- A TOPRIM domain in the crystal structure of the catalytic core of Escherichia coli primase confirms a structural link to DNA topoisomerases. (2000) (94)
- Crystal structure of the delta' subunit of the clamp-loader complex of E. coli DNA polymerase III. (1997) (94)
- Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity (2013) (93)
- Temperature dependence of the structure and dynamics of myoglobin. A simulation approach. (1990) (90)
- A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. (2006) (90)
- Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases (2019) (88)
- Structures of SH2 and SH3 domains (1993) (88)
- Thermal expansion of a protein. (1987) (87)
- The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2) (2009) (87)
- A reinterpretation of the dimerization interface of the N‐terminal Domains of STATs (2003) (87)
- Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless (2010) (84)
- Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS (2016) (80)
- Mechanism of Proliferating Cell Nuclear Antigen Clamp Opening by Replication Factor C* (2006) (79)
- Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker (2013) (79)
- Clamp loader ATPases and the evolution of DNA replication machinery (2012) (79)
- Deconstruction of the Ras switching cycle through saturation mutagenesis (2017) (78)
- DNA polymerase clamp loaders and DNA recognition (2005) (78)
- X-ray structure of trypanothione reductase from Crithidia fasciculata at 2.4-A resolution. (1991) (77)
- Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction (2019) (76)
- Monovalent and Multivalent Ligation of the B Cell Receptor Exhibit Differential Dependence upon Syk and Src Family Kinases (2013) (74)
- Directed evolution of the epidermal growth factor receptor extracellular domain for expression in yeast (2005) (74)
- Structural insights into the role of iron–histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins (2014) (74)
- Molecular mechanism of activation-triggered subunit exchange in Ca2+/calmodulin-dependent protein kinase II (2016) (73)
- Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1 (2013) (72)
- Crystal structure of the chi:psi sub-assembly of the Escherichia coli DNA polymerase clamp-loader complex. (2004) (72)
- Crystal Structure of the FLT3 Kinase Domain Bound to the Inhibitor Quizartinib (AC220) (2015) (72)
- Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II. (2013) (72)
- Emerging concepts in the regulation of the EGF receptor and other receptor tyrosine kinases. (2014) (71)
- Clamp loaders and replication initiation. (2006) (70)
- The Replication Factor C Clamp Loader Requires Arginine Finger Sensors to Drive DNA Binding and Proliferating Cell Nuclear Antigen Loading*♦ (2006) (70)
- Out-of-plane motions in open sliding clamps: molecular dynamics simulations of eukaryotic and archaeal proliferating cell nuclear antigen. (2005) (69)
- Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate (2015) (67)
- An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor (2016) (65)
- A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70 (2016) (65)
- Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless. (2005) (64)
- Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor (2015) (63)
- Structural analysis of the inactive state of the Escherichia coli DNA polymerase clamp-loader complex. (2004) (62)
- Tuning a three-component reaction for trapping kinase substrate complexes. (2008) (61)
- The Influence of the Proliferating Cell Nuclear Antigen-interacting Domain of p21CIP1 on DNA Synthesis Catalyzed by the Human and Saccharomyces cerevisiae Polymerase δ Holoenzymes* (1997) (58)
- Macromolecular juggling by ubiquitylation enzymes (2013) (54)
- Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain (2011) (52)
- Semisynthesis of hyperphosphorylated type I TGFβ receptor: Addressing the mechanism of kinase activation [20] (2000) (51)
- Mapping the interaction of DNA with the Escherichia coli DNA polymerase clamp loader complex (2005) (48)
- Crystallization of proliferating cell nuclear antigen (PCNA) from Saccharomyces cerevisiae. (1994) (47)
- Efficient semisynthesis of a tetraphosphorylated analogue of the Type I TGFbeta receptor. (2002) (46)
- The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway (2015) (45)
- Engineering the substrate specificity of glutathione reductase toward that of trypanothione reduction. (1991) (44)
- Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination (2019) (44)
- The Src module: an ancient scaffold in the evolution of cytoplasmic tyrosine kinases (2018) (43)
- Crystallization of DsbA, an Escherichia coli protein required for disulphide bond formation in vivo. (1993) (39)
- A structural role for the PHP domain in E. coli DNA polymerase III (2013) (39)
- A structural atlas of kinases inhibited by clinically approved drugs. (2014) (39)
- CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks (2020) (38)
- The sliding clamp of DNA polymerase III holoenzyme encircles DNA. (1992) (37)
- Multiple interactions between an Arf/GEF complex and charged lipids determine activation kinetics on the membrane (2017) (37)
- A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45. (2017) (37)
- Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen (2018) (37)
- Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless. (2003) (37)
- A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2+/Calmodulin- Dependent Kinase II Holoenzyme (2011) (35)
- Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response (2009) (35)
- X-ray refinement of protein structures by simulated annealing: test of the method on myohemerythrin. (1989) (35)
- The Interdependent Activation of Son-of-Sevenless and Ras. (2019) (34)
- Nucleotide-induced conformational changes in an isolated Escherichia coli DNA polymerase III clamp loader subunit. (2003) (33)
- Structural Insights into the Regulation of Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII). (2020) (33)
- Fluorescence measurements on the E.coli DNA polymerase clamp loader: implications for conformational changes during ATP and clamp binding. (2004) (33)
- Structural insights into the molecular mechanism of H‐NOX activation (2010) (33)
- C2 Can Do It, Too (2005) (32)
- Reciprocal Regulation of Hck Activity by Phosphorylation of Tyr527 and Tyr416 (2000) (32)
- Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium (2006) (31)
- Structure and specificity of the SH2 domain (2004) (30)
- Switch-like activation of Bruton’s tyrosine kinase by membrane-mediated dimerization (2018) (28)
- A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1 (2017) (27)
- The Tyrosine Kinase Csk Dimerizes through Its SH3 Domain (2009) (25)
- Structural basis and regulation of the reductive stress response (2021) (25)
- Mechanism of Processivity Clamp Opening by the Delta Subunit Wrench of the Clamp Loader Complex of E. coli DNA Polymerase III: Structure of the beta-delta complex (2001) (24)
- Analysis of a Multicomponent Thermostable DNA Polymerase III Replicase from an Extreme Thermophile* (2002) (24)
- Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation (2019) (23)
- Estimation of uncertainties in X‐ray refinement results by use of perturbed structures (1987) (23)
- Understanding molecular mechanisms in cell signaling through natural and artificial sequence variation (2018) (22)
- Structural basis for dimerization quality control (2020) (22)
- Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity. (2015) (22)
- Deep mutational analysis reveals functional trade-offs in the sequences of EGFR autophosphorylation sites (2018) (22)
- Differences in flexibility underlie functional differences in the Ras activators son of sevenless and Ras guanine nucleotide releasing factor 1. (2009) (22)
- Correction: Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity (2014) (21)
- Challenges at the frontiers of structural biology. (1999) (20)
- GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain (2021) (20)
- Comparative analysis of mutant tyrosine kinase chemical rescue. (2009) (19)
- Crystal Structure of a Ube2S-Ubiquitin Conjugate (2016) (19)
- Thermus thermophilis dnaX Homolog Encoding γ- and τ-like Proteins of the Chromosomal Replicase* (1997) (19)
- A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor (2020) (18)
- Structure of the NF-κB transcription factor: a holistic interaction with DNA (1995) (17)
- SAXS and the working protein. (2005) (17)
- Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase (2020) (16)
- Regulation of the c-Abl and BcrAbl Tyrosine Kinases (2004) (16)
- A two-component protein condensate of the EGFR cytoplasmic tail and Grb2 regulates Ras activation by SOS at the membrane (2022) (16)
- Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. (2015) (15)
- Allostery and Coupled Sequence Variation in Nuclear Hormone Receptors (2004) (13)
- CRYSTAL-STRUCTURE OF THE PHOSPHOTYROSINE RECOGNITION DOMAIN (SH2) OF THE V-SRC TYROSINE KINASE COMPLEXED WITH TYROSINE PHOSPHORYLATED PEPTIDES (1993) (13)
- Protein recognition: An SH2 domain in disguise (1999) (12)
- Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen (2017) (10)
- CALMODULIN-DEPENDENT PROTEIN KINASE FROM RAT (1998) (10)
- Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction (2021) (10)
- Variation in assembly stoichiometry in non‐metazoan homologs of the hub domain of Ca2+/calmodulin‐dependent protein kinase II (2019) (9)
- Variation in assembly stoichiometry in non-metazoan homologs of the hub domain of Ca2+/Calmodulin-dependent protein kinase II (2019) (9)
- Preliminary crystallographic analysis of trypanothione reductase from Crithidia fasciculata. (1990) (9)
- Crystallization and preliminary x-ray characterization of thioredoxin reductase from Escherichia coli. (1989) (8)
- Structure of the NF-kappa B transcription factor: a holistic interaction with DNA. (1995) (8)
- Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment (2009) (8)
- Peptide recognition mechanisms of eukaryotic signaling modules. (1998) (7)
- Modular protein structures (1993) (7)
- Structural basis for the auto-inhibition of c-Abl tyrosine kinase (2003) (7)
- Crystal Structure of a Ube 2 S-Ubiquitin Conjugate (2016) (7)
- Crystal structure of an oxygen binding H-NOX domain related to soluble guanylate cyclases (Water-ligated, ferric form) (2004) (6)
- A MAPK Scaffold Lends a Helping Hand (2009) (6)
- Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein (2022) (6)
- A saturation-mutagenesis analysis of the interplay between stability and activation in Ras (2022) (6)
- Fixing a Hole Where the Ras Gets In (2013) (6)
- Crystal Structure of the c-Abl Kinase domain in complex with PD173955 (2002) (5)
- The x-ray structure of flavohemoglobin. A semisynthetic hydroxylase. (1988) (5)
- Phosphorylation control of the ubiquitin ligase Cbl is conserved in choanoflagellates (2018) (5)
- Relating cellular signaling timescales to single-molecule kinetics: A first-passage time analysis of Ras activation by SOS (2021) (5)
- Validation of FLT3-ITD As a Therapeutic Target in Human Acute Myeloid Leukemia (2011) (5)
- Differences in the dynamics of the tandem‐SH2 modules of the Syk and ZAP‐70 tyrosine kinases (2021) (5)
- John T. Edsall and Advances in Protein Chemistry. (2002) (4)
- Crystal Structure of the FLT 3 Kinase Domain Bound to the Inhibitor Quizartinib ( AC 220 ) (2015) (4)
- The Molecules of Life (2012) (4)
- Author response: Molecular basis for multimerization in the activation of the epidermal growth factor receptor (2016) (4)
- A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca 2+/Calmodulin- Dependent Kinas (2011) (4)
- Crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (HER3) (2009) (3)
- A highly efficient peptide substrate for EGFR activates the kinase by inducing aggregation. (2013) (3)
- Erratum: Membrane-dependent signal integration by the Ras activator Son of sevenless (2008) (3)
- Clamp loader ATPases and the evolution of DNA replication machinery (2012) (3)
- Cell science and protein crystal growth research for the International Space Station (2000) (2)
- Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the pre-hairpin intermediate of the spike protein (2022) (2)
- Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction (2019) (2)
- Variation in assembly stoichiometry in non-metazoan homologs of the hub domain of Ca2+/Calmodulin-dependent protein kinase II. (2019) (2)
- Gammaretroviral pol sequences act in cis to direct polysome loading and NXF 1 / NXT-dependent protein production by gag-encoded RNA (2017) (2)
- DNA recognition, warts and all (1992) (2)
- A two-component protein condensate of EGFR and Grb2 regulates Ras activation at the membrane (2021) (2)
- Crystal structure of the Histone domain, DH-PH unit, and catalytic unit of the Ras activator Son of Sevenless (SOS) (2010) (1)
- New insights into Raf regulation from structural analyses. (2021) (1)
- SRC FAMILY KINASE HCK-QUERCETIN COMPLEX (1997) (1)
- c-Src kinase domain Thr338Ile mutant in complex with ATPgS (2008) (1)
- Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464His, and Phe467Met mutant human CaMKII alpha hub bound to 5-HDC (2021) (1)
- Molecular Mechanisms of DNA Polymerase Clamp Loaders (2012) (1)
- Molecular Timing of Membrane Signaling Reactions (2018) (1)
- A Unified Mechanism of Tyrosine Kinase Regulation by the Gatekeeper Residue. (2007) (1)
- A structural mechanism for the generation of biased agonism in the epidermal growth factor receptor (2020) (1)
- Author response: Molecular mechanism of activation-triggered subunit exchange in Ca2+/calmodulin-dependent protein kinase II (2016) (1)
- STAT-4 N-DOMAIN (1998) (1)
- Crystal Structure of the active EGFR kinase domain in complex with an ATP analog-peptide conjugate (2006) (1)
- Sliding Clamps in DNA Replication: E. coli β-Clamp and PCNA Structure (2004) (1)
- Surveillance of plant parasitic nematodes of different crops in homesteads of Kerala. (1990) (1)
- Macromolecular juggling by ubiquitylation enzymes (2013) (1)
- Crystal Structure of the inactive EGFR kinase domain in complex with AMP-PNP (2006) (1)
- Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases (2021) (1)
- Author response: Deconstruction of the Ras switching cycle through saturation mutagenesis (2017) (1)
- Direct coupling of Ras to preformed maleimide-functionalized lipid membranes (2010) (1)
- Quinone Reductase 2 (2009) (1)
- Saturation mutagenesis of a predicted ancestral Syk‐family kinase (2022) (1)
- Crystal structure of an oxygen binding H-NOX domain related to soluble guanylate cyclases (oxygen complex) (2004) (1)
- Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L67W mutant (2011) (0)
- Author response: A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor (2021) (0)
- Crystal Structure of the E. coli clamp loader bound to Primer-Template DNA and Psi Peptide (2009) (0)
- STRUCTURAL BASIS FOR THE REGULATION OF THE T-CELL TYROSINE KINASE ZAP-70 (2013) (0)
- Dissecting the Divergent Functions and Dynamics of ZAP-70 and SYK (2018) (0)
- CHAPTER 68 – Structures of Serine/Threonine and Tyrosine Kinases (2003) (0)
- ATPgS Bound E. Coli Clamp Loader Complex (2004) (0)
- Nucleotide bound form of an isolated E. coli clamp loader gamma subunit (2003) (0)
- Crystal Structure of NtrC4 DNA-binding domain bound to double-stranded DNA (2012) (0)
- Structural basis for dimerization quality control (2020) (0)
- Structural Analysis of Signaling By SH2 and SH3 Domains (1998) (0)
- Crystal structure of calcium/calmodulin-dependent protein kinase (2003) (0)
- Crystal structure of S. rosetta CaMKII hub (2016) (0)
- Structural basis for the chemical rescue of Src kinase activity (2009) (0)
- H-Ras bound to GMP-PNP at 277K (2017) (0)
- Autoinhibited state of the Ras-specific exchange factor RasGRP1 (2013) (0)
- Full-length human CaMKII (2011) (0)
- Crystal structure of an SH2-kinase domain construct of c-Abl tyrosine kinase (2015) (0)
- Supplemental Data An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor (2006) (0)
- H-Ras mutant L120A bound to GMP-PNP at 277K (2017) (0)
- c-Src kinase domain in complex with small molecule inhibitor (2008) (0)
- COMPLEX OF HUMAN H-RAS WITH HUMAN SOS-1 (1999) (0)
- A Phosphosite within the S H 2 Domain of Lck Regulates Its Activation by CD 45 Graphical Abstract (2017) (0)
- Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS) (2004) (0)
- CaMKII Substrate Complex A (2010) (0)
- CRYSTAL STRUCTURE OF THE DELTA PRIME SUBUNIT OF THE CLAMP-LOADER COMPLEX OF ESCHERICHIA COLI DNA POLYMERASE III (1998) (0)
- Choanoflagellate Salpingoeca rosetta Ras with GDP bound (2017) (0)
- Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide (2007) (0)
- Crystal structure of S. rosetta CaMKII kinase domain (2016) (0)
- Structure of a substrate-bound DQC ubiquitin ligase (2020) (0)
- structural on the regulation of the epidermal growth factor receptor. (2018) (0)
- Crystal structure of an H-NOX protein from S. oneidensis in the Fe(II)CO ligation state, Q154A/Q155A/K156A mutant (2014) (0)
- ZAP-70-tSH2:Compound-B adduct (2015) (0)
- Author response: A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1 (2017) (0)
- KARYOPHERIN ALPHA FROM SACCHAROMYCES CEREVISIAE (1999) (0)
- Crystal structure of the beta subunit from DNA polymerase of Streptococcus pyogenes (2006) (0)
- Author response: An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor (2016) (0)
- Crystal Structure of the Kinase Domain of ABL in Complex with a Potent Rationally-Designed Derivative of the PP1 Inhibitor, AB129 (2012) (0)
- The structure of V98A S172A Keap1-BTB domain (2020) (0)
- Crystal Structure of the E. coli clamp loader bound to Psi Peptide (2009) (0)
- Single Molecule Study of the Processive Ras/SOS Interaction (2012) (0)
- X11 PTB DOMAIN (1998) (0)
- CaMKIINtide Inhibitor Complex (2010) (0)
- Crystal Structure of the active EGFR kinase domain (2006) (0)
- Editorial Board (1995) (0)
- Crystal Structure of the Auto-Inhibited Kinase Domain of Calcium/Calmodulin Activated Kinase II (2005) (0)
- Crystal Structure of the Cdc25 domain of RasGRF1 (2006) (0)
- KARYOPHERIN ALPHA (YEAST) + SV40 T ANTIGEN NLS (1999) (0)
- Title An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor (2016) (0)
- CRYSTAL STRUCTURE OF ABL KINASE DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR (2000) (0)
- Crystal structure of the EGFR kinase domain mutant I682Q (2015) (0)
- Inhibition of BCR/ABL-T315I by Dismantling the Hydrophobic Spine. (2008) (0)
- HOMEODOMAIN FROM THE DROSOPHILA PAIRED PROTEIN BOUND TO A DNA OLIGONUCLEOTIDE (1996) (0)
- Crystal structure of N. vectensis CaMKII-A hub (2016) (0)
- Crystal Structure of chicken c-Src kinase domain in complex with the cancer drug imatinib. (2007) (0)
- The Effects of Protein Dynamics on Immune System Signaling Pathways (2017) (0)
- The Residence Time and Processivity Study of the Ras/Sos Interaction (2011) (0)
- c-Kit Receptor Tyrosine Kinases Characterization of Potent Inhibitors of the Bcr-Abl and the Updated (2002) (0)
- The structure of the F64A, S172A mutant Keap1-BTB domain in complex with SKP1-FBXL17 (2020) (0)
- Crystal structure of the apo SH2 domains of Syk (2021) (0)
- CRYSTAL STRUCTURE OF THE PROCESSIVITY CLAMP GP45 FROM BACTERIOPHAGE T4 (2000) (0)
- Solution structure of RasGRP2 EF hands bound to calcium (2013) (0)
- Structure of T4 Bacteriophage Clamp Loader Bound To Open Clamp, DNA and ATP Analog (2012) (0)
- Structure of RasGRP2 in complex with Rap1B (2017) (0)
- Stimulation of the catalytic activity of the tyrosine kinase Btk by the adaptor protein Grb2 (2022) (0)
- Author response: Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1 (2013) (0)
- CRYSTAL STRUCTURE OF THE ATYPICAL PROTEIN KINASE DOMAIN OF A TRP CA-CHANNEL, CHAK (APO) (2001) (0)
- Src Thr338Ile inhibited in the DFG-Asp-Out conformation (2009) (0)
- Crystal Structure of the Histone domain of Son of Sevenless (2003) (0)
- The structure of F64, S172A Keap1-BTB domain (2020) (0)
- Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L66W/L67W double mutant (2011) (0)
- Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120 under 6 atm of xenon (2011) (0)
- X11 PTB DOMAIN-10MER PEPTIDE COMPLEX (1997) (0)
- Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120 under 1 atm of xenon (2011) (0)
- Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L66W mutant under 6 atm of xenon (2011) (0)
- Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L66W mutant (2011) (0)
- H-Ras mutant L120A bound to GMP-PNP at 100K (2017) (0)
- Experimentally Phased Structure of Human the Son of Sevenless protein at 4.1 Ang. (2004) (0)
- Refreshing memories The exchange of CaMKII enzymes between larger structures called holoenzymes may provide the molecular mechanism underlying the long-term stability of memories. (2014) (0)
- Single Molecule Processivity of SOS-cat, the Catalytic Core of the Ras Gef ‘son of Sevenless’ (2011) (0)
- Structure of T4 Bacteriophage Clamp Loader Bound To Closed Clamp, DNA and ATP Analog and ADP (2012) (0)
- Crystal structure of the kinase domain of a receptor tyrosine kinase from a choanoflagellate, Monosiga brevicollis (2022) (0)
- Transcription factors. DNA recognition, warts and all. (1992) (0)
- Crystal structure of E. coli sliding clamp (beta) bound to a polymerase III peptide (2008) (0)
- Understanding molecular mechanisms in cell signaling through natural and artificial sequence variation (2018) (0)
- Award Winners and Abstracts of the 31st Annual Symposium of The Protein Society, Montreal, Canada, July 24–27, 2017 (2017) (0)
- Characterization of heme protein sensors provides a basis for functional differences such as ligand recognition (2003) (0)
- Structure of C-terminal coiled coil of RasGRP1 (2013) (0)
- CYTOPLASMIC DOMAIN OF UNPHOSPHORYLATED TYPE I TGF-BETA RECEPTOR CRYSTALLIZED WITHOUT FKBP12 (2001) (0)
- The β Sliding Clamp of E. coli DNA Polymerase III Holoenzyme Balances Opposing Functions (1994) (0)
- GHB confers neuroprotection by stabilizing the CaMKIIα hub domain (2020) (0)
- Structure of T4 Bacteriophage clamp loader bound to the T4 clamp, primer-template DNA, and ATP analog (2012) (0)
- The structure of S172A Keap1-BTB domain (2020) (0)
- ZAP-70-tSH2:compound-A complex (2015) (0)
- Crystal Structure of a Mutant (gammaT157A) E. coli Clamp Loader Bound to Primer-Template DNA (2009) (0)
- Crystal structure of an H-NOX protein from T. tengcongensis under 6 atm of xenon (2011) (0)
- HIV-1 NEF PROTEIN IN COMPLEX WITH R96I MUTANT FYN SH3 DOMAIN (1997) (0)
- Measuring Membrane Surface Reactions by Diffusion: Dimerization of Btk PH Domain and K-Ras (2018) (0)
- CHAPTER 62 – JAK–STAT Signaling (2003) (0)
- Author response: CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks (2020) (0)
- A molecular view of the regulation of sGC activity (2009) (0)
- Structural Analysis of Processive DNA Replication (2006) (0)
- Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT (2018) (0)
- Protein serine/threonine phosphatase-1 (alpha isoform, type 1) complexed with microcystin-LR toxin (1996) (0)
- Eukaryotic Sliding Clamp PCNA Bound to DNA (2010) (0)
- Functional Dynamics and Allosteric Regulation of Ras Activation by SOS (2013) (0)
- EGFR transmembrane - juxtamembrane (TM-JM) segment in bicelles: MD guided NMR refined structure. (2013) (0)
- Bruton's Tyrosine Kinase Membrane Dynamics and Signaling (2020) (0)
- Crystal structure of the human CaMKII-alpha hub (2016) (0)
- Structure of E. coli Pol III 3mPHP mutant (2013) (0)
- chicken c-Src kinase domain in complex with ATPgS (2008) (0)
- Inactive choanoflagellate E3 ubiquitin ligase Cbl TKB (2018) (0)
- TYROSINE PHOSPHORYLATED STAT-1/DNA COMPLEX (1998) (0)
- Protein Assembly on Membrane Surface alters the Dynamical Spectrum of Downstream Signaling Reactions (2016) (0)
- Inhibition of the T-cell Kinase ZAP-70 by Patrick Ramos Visperas A dissertation submitted in partial satisfaction of the requirements for the degree of Doctor of Philosophy in Molecular and Cell Biology in the Graduate Division (2013) (0)
- Crystal structure of an H-NOX protein from S. oneidensis in the Fe(II)NO ligation state (2014) (0)
- Crystal Structure of the Eukaryotic Clamp Loader (Replication Factor C, RFC) Bound to the DNA Sliding Clamp (Proliferating Cell Nuclear Antigen, PCNA) (2004) (0)
- DBL AND PLECKSTRIN HOMOLOGY DOMAINS FROM HSOS1 (1998) (0)
- Structure of RasGRP4 in complex with HRas (2017) (0)
- First view of a tyrosine phosphatase structure. (1994) (0)
- Crystal structure of the PH-TH-kinase construct of Bruton's tyrosine kinase (Btk) (2015) (0)
- Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120 (2011) (0)
- Editorial Board (1995) (0)
- Drug discovery targeting SARS-CoV-2 membrane fusion (2023) (0)
- The Association Domain of C. elegans CaMKII (2006) (0)
- CRYSTAL STRUCTURE OF THE ATYPICAL PROTEIN KINASE DOMAIN OF A TRP CA-CHANNEL, CHAK (ADP-MG COMPLEX) (2001) (0)
- Clustering of Ras on Membrane Surfaces Independent of Lipid Anchor Effects (2013) (0)
- Crystal structure of the kinase domain of Bruton's tyrosine kinase with mutations in the activation loop (2015) (0)
- Crystal structure of N. vectensis CaMKII-B hub at pH 4.2 (2016) (0)
- Crystal structure of the PH-TH module of Bruton's tyrosine kinase bound to inositol hexakisphosphate (2015) (0)
- B-Raf:14-3-3 complex (2019) (0)
- Crystal Structure of the Ecoli Clamp Loader Bound to Primer-Template DNA (2009) (0)
- Allosteric Mechanisms in Receptor Tyrosine Kinase Activation (2009) (0)
- SRC FAMILY KINASE HCK-AMP-PNP COMPLEX (1997) (0)
- A replicase sliding clamp bound to DNA and a novel chemical compound that inhibits DNA replication (2008) (0)
- CRYSTAL STRUCTURE OF AN ARCHAEBACTERIAL DNA POLYMERASE D.TOK. DEPOSITION OF SECOND NATIVE STRUCTURE AT 2.4 ANGSTROM (2000) (0)
- Beyond the Gatekeeper: Imatinib- and Dasatinib-Resistant BCR-ABL/F317 Mutations Confer Cross-Resistance to VX-680 but Are Sensitive to a Structural Derivative of VX-680 (2008) (0)
- CRYSTAL-STRUCTURES OF PEPTIDE COMPLEXES OF SH2 DOMAINS (1994) (0)
- Structure of a small molecule inhibitor bound to a DNA sliding clamp (2008) (0)
- Crystal structure of chi and psi subunit heterodimer from DNA POL III (2003) (0)
- Structure and Mechanism of the DNA Polymerase Processivity Clamp (2002) (0)
- Editorial Board (1995) (0)
- Total Reconstitution of Receptor-Mediated Ras Activation by SOS in Vitro Reveals Kinetic and Conformational Layers of Regulation in MAPK Signaling (2019) (0)
- E.COLI PRIMASE CATALYTIC CORE (2000) (0)
- Crystal Structure of catalytic domain of Son of sevenless (Rem-Cdc25) in the absence of Ras (2006) (0)
- Crystal structure of an H-NOX protein from T. tengcongensis (2011) (0)
- Structural Properties of Human CaMKII Ca2$+$/Calmodulin-Dependent Protein Kinase II using X-ray Crystallography (2016) (0)
- Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464His, and Phe467Met mutant human CamKII-alpha hub domain (2019) (0)
- Crystal Structure of a ternary Ras:SOS:Ras*GDP complex (2004) (0)
- Structure of the Chlamydamonas reinhardtii CamKII hub homology domain (2019) (0)
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