John Mekalanos

Q: What Schools Are Affiliated With John Mekalanos

John Mekalanos is affiliated with the following schools: University of Texas Medical Branch, University of California, Los Angeles, University of Chicago, University System of Maryland, Johns Hopkins University, University of Washington, Massachusetts General Hospital, Harvard University

John Mekalanos's AcademicInfluence.com Rankings

John Mekalanos

Biology

#3790

World Rank

#5745

Historical Rank

Microbiology

#118

World Rank

#141

Historical Rank

biology Degrees

Download Badge

Biology

Why Is John Mekalanos Influential?

(Suggest an Edit or Addition)

According to Wikipedia, John Mekalanos is a microbiologist who is primarily known for leading one of the first teams that reported the discovery of the type VI secretion system as well as his work on the pathogenicity of the bacterial species Vibrio cholerae, its toxin, and its secretion systems. Since 1998, he has been a member of the National Academy of Sciences.

(See a Problem?)

John Mekalanos's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR (1988) (2245)
DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae (2000) (1790)
Lysogenic Conversion by a Filamentous Phage Encoding Cholera Toxin (1996) (1750)
Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system (2006) (1037)
Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin. (1987) (1001)
A Virulence Locus of Pseudomonas aeruginosa Encodes a Protein Secretion Apparatus (2006) (994)
A two-component regulatory system (phoP phoQ) controls Salmonella typhimurium virulence. (1989) (942)
Epidemiology, Genetics, and Ecology of ToxigenicVibrio cholerae (1998) (936)
Environmental signals controlling expression of virulence determinants in bacteria (1992) (841)
Quorum-sensing regulators control virulence gene expression in Vibrio cholerae (2002) (840)
The origin of the Haitian cholera outbreak strain. (2011) (693)
Toxin, toxin-coregulated pili, and the toxR regulon are essential for Vibrio cholerae pathogenesis in humans (1988) (682)
Type VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin (2007) (655)
Coordinate regulation and sensory transduction in the control of bacterial virulence. (1989) (639)
Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development (1983) (614)
Cholera toxin transcriptional activator ToxR is a transmembrane DNA binding protein (1987) (603)
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin (2009) (577)
Type VI secretion requires a dynamic contractile phage tail-like structure (2012) (544)
Quorum sensing-dependent biofilms enhance colonization in Vibrio cholerae. (2003) (523)
New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis. (2007) (484)
A view to a kill: the bacterial type VI secretion system. (2014) (465)
Regulatory cascade controls virulence in Vibrio cholerae. (1991) (461)
Comparative genomic analysis of Vibrio cholerae: Genes that correlate with cholera endemic and pandemic disease (2002) (451)
Constitutive expression of the phoP regulon attenuates Salmonella virulence and survival within macrophages (1990) (422)
Duplication and amplification of toxin genes in Vibrio cholerae (1983) (414)
PAAR-repeat proteins sharpen and diversify the Type VI secretion system spike (2013) (412)
Tit-for-Tat: Type VI Secretion System Counterattack during Bacterial Cell-Cell Interactions (2013) (405)
A new type of conjugative transposon encodes resistance to sulfamethoxazole, trimethoprim, and streptomycin in Vibrio cholerae O139 (1996) (379)
In vivo transposition of mariner-based elements in enteric bacteria and mycobacteria. (1999) (370)
A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae (2002) (370)
Monoclonal secretory immunoglobulin A protects mice against oral challenge with the invasive pathogen Salmonella typhimurium (1992) (348)
Coordinated Regulation of Accessory Genetic Elements Produces Cyclic Di-Nucleotides for V. cholerae Virulence (2012) (345)
ExsE, a secreted regulator of type III secretion genes in Pseudomonas aeruginosa (2005) (342)
Iron regulation of Shiga-like toxin expression in Escherichia coli is mediated by the fur locus (1987) (342)
Seasonal epidemics of cholera inversely correlate with the prevalence of environmental cholera phages. (2005) (323)
Synthesis of cholera toxin is positively regulated at the transcriptional level by toxR. (1984) (322)
TcpP protein is a positive regulator of virulence gene expression in Vibrio cholerae. (1998) (318)
Identification of a vibrio cholerae RTX toxin gene cluster that is tightly linked to the cholera toxin prophage. (1999) (312)
Transmissibility of cholera: in vivo-formed biofilms and their relationship to infectivity and persistence in the environment. (2006) (295)
The human pathogen Pseudomonas aeruginosa utilizes conserved virulence pathways to infect the social amoeba Dictyostelium discoideum (2002) (292)
Threonine phosphorylation post-translationally regulates protein secretion in Pseudomonas aeruginosa (2007) (284)
Systematic identification of essential genes by in vitro mariner mutagenesis. (1998) (282)
Alterations in Vibrio cholerae motility phenotypes correlate with changes in virulence factor expression (1996) (280)
Use of recombinase gene fusions to identify Vibrio cholerae genes induced during infection (1995) (277)
Hyperactive transposase mutants of the Himar1 mariner transposon. (1999) (266)
Use of signature‐tagged transposon mutagenesis to identify Vibrio cholerae genes critical for colonization (1998) (264)
New model for analysis of mucosal immunity: intestinal secretion of specific monoclonal immunoglobulin A from hybridoma tumors protects against Vibrio cholerae infection (1991) (260)
Translocation of a Vibrio cholerae type VI secretion effector requires bacterial endocytosis by host cells. (2009) (259)
Staphylococcal enterotoxin A is encoded by phage. (1985) (258)
Broad-host-range vectors for delivery of TnphoA: use in genetic analysis of secreted virulence determinants of Vibrio cholerae (1989) (257)
Identification of T6SS-dependent effector and immunity proteins by Tn-seq in Vibrio cholerae (2013) (256)
Antibiotic-based selection for bacterial genes that are specifically induced during infection of a host. (1995) (248)
Nucleotide sequence of the Shiga-like toxin genes of Escherichia coli. (1987) (246)
Determination of the transcriptome of Vibrio cholerae during intraintestinal growth and midexponential phase in vitro (2003) (238)
Alkaline phosphatase fusions: sensors of subcellular location (1990) (236)
CTX genetic element encodes a site-specific recombination system and an intestinal colonization factor. (1993) (234)
Type 6 Secretion Dynamics Within and Between Bacterial Cells (2012) (224)
In vivo genetic analysis of bacterial virulence. (1999) (221)
Characterization of the Vibrio cholerae ToxR Regulon: Identification of Novel Genes Involved in Intestinal Colonization (1989) (221)
Self-limiting nature of seasonal cholera epidemics: Role of host-mediated amplification of phage (2005) (221)
Small-Molecule Inhibitor of Vibrio cholerae Virulence and Intestinal Colonization (2005) (216)
Tn-Seq analysis of Vibrio cholerae intestinal colonization reveals a role for T6SS-mediated antibacterial activity in the host. (2013) (209)
Regulation, replication, and integration functions of the Vibrio cholerae CTXφ are encoded by region RS2 (1997) (207)
Identification of toxS, a regulatory gene whose product enhances toxR-mediated activation of the cholera toxin promoter (1989) (206)
Enzymic activity of cholera toxin. II. Relationships to proteolytic processing, disulfide bond reduction, and subunit composition. (1979) (204)
A hybrid approach for the automated finishing of bacterial genomes (2012) (204)
A defined transposon mutant library and its use in identifying motility genes in Vibrio cholerae (2008) (203)
Nucleotide sequence of the type A staphylococcal enterotoxin gene (1988) (203)
RNA-Seq-based monitoring of infection-linked changes in Vibrio cholerae gene expression. (2011) (202)
Genetic diversity and virulence potential of environmental Vibrio cholerae population in a cholera-endemic area (2004) (200)
Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system. (2005) (195)
In vivo actin cross-linking induced by Vibrio cholerae type VI secretion system is associated with intestinal inflammation (2010) (194)
Modeling the role of bacteriophage in the control of cholera outbreaks. (2006) (193)
Role of the Type III Secreted Exoenzymes S, T, and Y in Systemic Spread of Pseudomonas aeruginosa PAO1 In Vivo (2005) (192)
Bacterial cGAS-like enzymes synthesize diverse nucleotide signals (2019) (189)
ToxR regulon of Vibrio cholerae and its expression in vibrios shed by cholera patients (2003) (187)
Pathogenicity islands and phages in Vibrio cholerae evolution. (2003) (187)
Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance (2018) (187)
The Vibrio cholerae O139 serogroup antigen includes an O-antigen capsule and lipopolysaccharide virulence determinants. (1994) (185)
Distinct roles of an alternative sigma factor during both free‐swimming and colonizing phases of the Vibrio cholerae pathogenic cycle (1998) (184)
Vibrio parahaemolyticus has a homolog of the Vibrio cholerae toxRS operon that mediates environmentally induced regulation of the thermostable direct hemolysin gene (1993) (182)
The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase (2004) (181)
Genetic Analysis of Anti-Amoebae and Anti-Bacterial Activities of the Type VI Secretion System in Vibrio cholerae (2011) (180)
In vivo covalent cross‐linking of cellular actin by the Vibrio cholerae RTX toxin (2000) (175)
Two trans-acting regulatory genes (vir and mod) control antigenic modulation in Bordetella pertussis (1988) (171)
Use of genetic recombination as a reporter of gene expression. (1994) (171)
Genetic footprinting with mariner-based transposition in Pseudomonas aeruginosa. (2000) (168)
Genetic Characterization of a New Type IV-A Pilus Gene Cluster Found in Both Classical and El Tor Biotypes ofVibrio cholerae (1999) (167)
TnAraOut, A transposon-based approach to identify and characterize essential bacterial genes (2000) (167)
Vibrio cholerae tolC Is Required for Bile Resistance and Colonization (2001) (167)
Cyclic Dinucleotides and the Innate Immune Response (2013) (165)
Bile acids stimulate biofilm formation in Vibrio cholerae (2006) (161)
A type III secretion system in Vibrio cholerae translocates a formin/spire hybrid-like actin nucleator to promote intestinal colonization. (2007) (159)
In Vivo Transduction with Shiga Toxin 1-Encoding Phage (1998) (153)
Emergence of a new cholera pandemic: molecular analysis of virulence determinants in Vibrio cholerae O139 and development of a live vaccine prototype. (1994) (152)
Development of antimicrobial agents in the era of new and reemerging infectious diseases and increasing antibiotic resistance. (2001) (152)
Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner. (2005) (147)
Genetics of bacterial enterotoxins. (1986) (146)
Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium (1990) (145)
Evidence that glutamic acid 167 is an active-site residue of Shiga-like toxin I. (1988) (143)
Bacterial Genomics and Pathogen Evolution (2006) (142)
Phage-bacterial interactions in the evolution of toxigenic Vibrio cholerae (2012) (142)
Meeting Cholera's Challenge to Haiti and the World: A Joint Statement on Cholera Prevention and Care (2011) (142)
Effects of changes in membrane sodium flux on virulence gene expression in Vibrio cholerae. (1999) (141)
ToxR regulates virulence gene expression in non-O1 strains of Vibrio cholerae that cause epidemic cholera (1994) (138)
Expression of ToxR, the transcriptional activator of the virulence factors in Vibrio cholerae, is modulated by the heat shock response. (1990) (136)
Differential Regulation of Multiple Flagellins inVibrio cholerae (1998) (133)
Quorum sensing and a global regulator TsrA control expression of type VI secretion and virulence in Vibrio cholerae (2010) (132)
Fitness cost of antibiotic susceptibility during bacterial infection (2015) (130)
Safety, immunogenicity, and efficacy of live attenuated Vibrio cholerae 0139 vaccine prototype (1995) (129)
Effect of Metabolic Imbalance on Expression of Type III Secretion Genes in Pseudomonas aeruginosa (2004) (129)
Molecular cloning of Vibrio cholerae enterotoxin genes in Escherichia coli K-12. (1982) (128)
Analysis of the roles of antilipopolysaccharide and anti-cholera toxin immunoglobulin A (IgA) antibodies in protection against Vibrio cholerae and cholera toxin by use of monoclonal IgA antibodies in vivo (1993) (127)
Virstatin inhibits dimerization of the transcriptional activator ToxT (2007) (127)
Phase Variable O Antigen Biosynthetic Genes Control Expression of the Major Protective Antigen and Bacteriophage Receptor in Vibrio cholerae O1 (2012) (122)
Genetic regulation of bacterial virulence. (1989) (122)
Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence (2018) (122)
Proteomic analysis of Vibrio cholerae outer membrane vesicles (2014) (120)
Constitutive sensory transduction mutations in the Bordetella pertussis bvgS gene (1992) (120)
Confirmation of the Fur operator site by insertion of a synthetic oligonucleotide into an operon fusion plasmid (1988) (119)
Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing (2013) (118)
Effect of a recA mutation on cholera toxin gene amplification and deletion events (1986) (118)
The Contribution of Accessory Toxins of Vibrio cholerae O1 El Tor to the Proinflammatory Response in a Murine Pulmonary Cholera Model (2002) (117)
Molecular characterization of the oafA locus responsible for acetylation of Salmonella typhimurium O-antigen: oafA is a member of a family of integral membrane trans-acylases (1996) (116)
Generation of reactive oxygen species by lethal attacks from competing microbes (2015) (114)
Characterization of the Vibrio cholerae ToxR regulon: identification of novel genes involved in intestinal colonization (1988) (114)
Clinical and Environmental Isolates of Vibrio cholerae Serogroup O141 Carry the CTX Phage and the Genes Encoding the Toxin-Coregulated Pili (2001) (112)
Simultaneous prevention of glutamine synthesis and high-affinity transport attenuates Salmonella typhimurium virulence (1997) (111)
Safe, live Vibrio cholerae vaccines? (1988) (109)
A dually active anthrax vaccine that confers protection against both bacilli and toxins (2003) (108)
Transposon-based approaches to identify essential bacterial genes. (2000) (107)
The Drosophila Immune Deficiency Pathway Modulates Enteroendocrine Function and Host Metabolism. (2018) (107)
Analysis of Clinical and Environmental Strains of Nontoxigenic Vibrio cholerae for Susceptibility to CTXΦ: Molecular Basis for Origination of New Strains with Epidemic Potential (1998) (107)
Acetylation (O-factor 5) affects the structural and immunological properties of Salmonella typhimurium lipopolysaccharide O antigen (1995) (106)
Regulation of the stringent response is the essential function of the conserved bacterial G protein CgtA in Vibrio cholerae (2007) (106)
Peru-15, a live attenuated oral cholera vaccine, is safe and immunogenic in Bangladeshi toddlers and infants. (2007) (106)
Antibodies directed against the toxin-coregulated pilus isolated from Vibrio cholerae provide protection in the infant mouse experimental cholera model. (1990) (103)
Type 6 Secretion System–Mediated Immunity to Type 4 Secretion System–Mediated Gene Transfer (2013) (103)
Genomic analysis of the Mozambique strain of Vibrio cholerae O1 reveals the origin of El Tor strains carrying classical CTX prophage (2007) (103)
A Constitutively Active Variant of the Quorum-Sensing Regulator LuxO Affects Protease Production and Biofilm Formation in Vibrio cholerae (2003) (102)
Characterization of the RpoN regulon reveals differential regulation of T6SS and new flagellar operons in Vibrio cholerae O37 strain V52 (2012) (101)
Transcriptional Profiling of Vibrio cholerae Recovered Directly from Patient Specimens during Early and Late Stages of Human Infection (2005) (100)
Structure and mechanism of a cyclic trinucleotide-activated bacterial endonuclease mediating bacteriophage immunity (2019) (99)
Induction of the Lysogenic Phage Encoding Cholera Toxin in Naturally Occurring Strains of Toxigenic Vibrio cholerae O1 and O139 (1998) (96)
Satellite phage TLCϕ enables toxigenic conversion by CTX phage through dif site alteration (2010) (95)
In vivo expression technology for selection of bacterial genes specifically induced in host tissues. (1994) (95)
Neither the Bvg− Phase nor thevrg6 Locus of Bordetella pertussis Is Required for Respiratory Infection in Mice (1998) (93)
Cloning of the Vibrio cholerae recA gene and construction of a Vibrio cholerae recA mutant (1986) (91)
YgbQ, a cell division protein in Escherichia coli and Vibrio cholerae, localizes in codependent fashion with FtsL to the division site (2002) (90)
CBASS Immunity Uses CARF-Related Effectors to Sense 3′–5′- and 2′–5′-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection (2020) (90)
Acquisition of classical CTX prophage from Vibrio cholerae O141 by El Tor strains aided by lytic phages and chitin-induced competence (2008) (88)
Monoclonal immunoglobulin A antibodies directed against cholera toxin prevent the toxin-induced chloride secretory response and block toxin binding to intestinal epithelial cells in vitro (1993) (88)
ToxR regulates the production of lipoproteins and the expression of serum resistance in Vibrio cholerae. (1991) (87)
Regulation of cholera toxin by temperature, pH, and osmolarity. (1994) (87)
The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism. (2014) (85)
Cholera toxin: genetic analysis, regulation, and role in pathogenesis. (1985) (84)
Quartz crystal microbalance detection of Vibrio cholerae O139 serotype. (1995) (84)
Characterization of Vibrio cholerae bacteriophage K139 and use of a novel mini‐transposon to identify a phage‐encoded virulence factor (1995) (83)
Characterization of the Vibrio cholerae vexAB and vexCD efflux systems (2006) (82)
Purification of cholera toxin and its subunits: new methods of preparation and the use of hypertoxinogenic mutants (1978) (81)
Distribution of genes for virulence and ecological fitness among diverse Vibrio cholerae population in a cholera endemic area: tracking the evolution of pathogenic strains. (2008) (81)
Randomized, controlled study of the safety and immunogenicity of Peru-15, a live attenuated oral vaccine candidate for cholera, in adult volunteers in Bangladesh. (2005) (81)
Monoclonal immunoglobulin A prevents adherence and invasion of polarized epithelial cell monolayers by Salmonella typhimurium. (1994) (81)
Replication and integration of a Vibrio cholerae cryptic plasmid linked to the CTX prophage (1998) (79)
Secretome Analysis of Vibrio cholerae Type VI Secretion System Reveals a New Effector-Immunity Pair (2015) (79)
Vibrio cholerae T3SS effector VopE modulates mitochondrial dynamics and innate immune signaling by targeting Miro GTPases. (2014) (78)
Enzymic activity of cholera toxin. I. New method of assay and the mechanism of ADP-ribosyl transfer. (1979) (77)
Morphological studies on fimbriae expressed by Vibrio cholerae 01. (1988) (77)
Isolation of peptide aptamers that inhibit intracellular processes. (2000) (76)
Quorum-regulated biofilms enhance the development of conditionally viable, environmental Vibrio cholerae (2010) (74)
Expression of the Vibrio cholerae gene encoding aldehyde dehydrogenase is under control of ToxR, the cholera toxin transcriptional activator (1991) (74)
Lipoprotein e(P4) is essential for hemin uptake by Haemophilus influenzae (1996) (74)
Lysogenic Conversion of Environmental Vibrio mimicus Strains by CTXΦ (1999) (74)
Vibrio cholerae 0139 specific gene sequences (1994) (73)
2,3-Butanediol Synthesis and the Emergence of the Vibrio cholerae El Tor Biotype (2006) (72)
Mapping the regulon of Vibrio cholerae ferric uptake regulator expands its known network of gene regulation (2011) (72)
Association of Protease Activity in Vibrio choleraeVaccine Strains with Decreases in Transcellular Epithelial Resistance of Polarized T84 Intestinal Epithelial Cells (2000) (71)
Exopolysaccharide protects Vibrio cholerae from exogenous attacks by the type 6 secretion system (2018) (70)
Effect of Phage on the Infectivity of Vibrio cholerae and Emergence of Genetic Variants (2008) (69)
Quorum-sensing autoinducers resuscitate dormant Vibrio cholerae in environmental water samples (2013) (68)
RS1 Element of Vibrio cholerae Can Propagate Horizontally as a Filamentous Phage Exploiting the Morphogenesis Genes of CTXΦ (2002) (68)
Type III Secretion Is Essential for the Rapidly Fatal Diarrheal Disease Caused by Non-O1, Non-O139 Vibrio cholerae (2011) (67)
Microbiota-targeted maternal antibodies protect neonates from enteric infection (2020) (67)
Vibrio cholerae-Induced Cellular Responses of Polarized T84 Intestinal Epithelial Cells Are Dependent on Production of Cholera Toxin and the RTX Toxin (2001) (66)
Two-Component Signal Transduction and Its Role in the Expression of Bacterial Virulence Factors (1995) (64)
Emergence of Antimicrobial-Resistant Escherichia coli of Animal Origin Spreading in Humans. (2016) (63)
Genetic analysis of the cholera toxin-positive regulatory gene toxR (1985) (62)
Nucleotide Sequence and Spatiotemporal Expression of the Vibrio cholerae vieSAB Genes during Infection (1998) (62)
A new assay for invasion of HeLa 229 cells by Bordetella pertussis: effects of inhibitors, phenotypic modulation, and genetic alterations (1990) (62)
Cholera toxin promotes pathogen acquisition of host-derived nutrients (2019) (59)
rfb Mutations in Vibrio cholerae Do Not Affect Surface Production of Toxin-Coregulated Pili but Still Inhibit Intestinal Colonization (1999) (57)
Combining Anthrax Vaccine and Therapy: a Dominant-Negative Inhibitor of Anthrax Toxin Is Also a Potent and Safe Immunogen for Vaccines (2005) (57)
Cholera: molecular basis for emergence and pathogenesis. (1997) (56)
Vibrio cholerae type 6 secretion system effector trafficking in target bacterial cells (2017) (55)
Cloning and expression of the Salmonella enterotoxin gene (1987) (55)
Molecular cloning and characterization of two Helicobacter pylori genes coding for plasminogen-binding proteins (2004) (55)
Analysis of membrane protein interaction: ToxR can dimerize the amino terminus of phage lambda repressor (1994) (55)
A vir-repressed gene of Bordetella pertussis is required for virulence (1992) (55)
ToxR proteins with substitutions in residues conserved with OmpR fail to activate transcription from the cholera toxin promoter (1992) (55)
Quorum Regulated Resistance of Vibrio cholerae against Environmental Bacteriophages (2016) (55)
The Highly Conserved Bacterial RNase YbeY Is Essential in Vibrio cholerae, Playing a Critical Role in Virulence, Stress Regulation, and RNA Processing (2014) (55)
Reactogenicity of live-attenuated Vibrio cholerae vaccines is dependent on flagellins (2010) (53)
Role of cholera toxin in enteric colonization by Vibrio cholerae O1 in rabbits (1985) (53)
Heterologous antigen expression in Vibrio cholerae vector strains (1995) (53)
Selection for bacterial genes that are specifically induced in host tissues: the hunt for virulence factors. (1993) (52)
DNA Damage and Reactive Nitrogen Species are Barriers to Vibrio cholerae Colonization of the Infant Mouse Intestine (2011) (52)
The ToxR protein of Vibrio cholerae forms homodimers and heterodimers (1996) (51)
Examination of Diverse Toxin-Coregulated Pilus-Positive Vibrio cholerae Strains Fails To Demonstrate Evidence for Vibrio Pathogenicity Island Phage (2003) (51)
An improved technique for isolation of environmental Vibrio cholerae with epidemic potential: monitoring the emergence of a multiple-antibiotic-resistant epidemic strain in Bangladesh. (2006) (51)
Immunogenicity of Vibrio cholerae O1 toxin-coregulated pili in experimental and clinical cholera (1991) (48)
Isolation of enterotoxin structural gene deletion mutations in Vibrio cholerae induced by two mutagenic vibriophages. (1982) (45)
Functional Analysis of VopF Activity Required for Colonization in Vibrio cholerae (2010) (44)
Modulation of Horizontal Gene Transfer in Pathogenic Bacteria by In Vivo Signals (1996) (44)
Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli (2018) (43)
A live vaccine rapidly protects against cholera in an infant rabbit model (2018) (43)
Genomic Sequence and Receptor for the Vibrio cholerae Phage KSF-1Φ: Evolutionary Divergence among Filamentous Vibriophages Mediating Lateral Gene Transfer (2005) (42)
Evidence that modulation requires sequences downstream of the promoters of two vir-repressed genes of Bordetella pertussis (1990) (41)
MetR-Regulated Vibrio cholerae Metabolism Is Required for Virulence (2012) (41)
Characterization of vir-activated TnphoA gene fusions in Bordetella pertussis (1991) (40)
Analysis of Vibrio cholierae ToxR function by construction of novel fusion proteins (1995) (40)
Genetic mapping of toxin regulatory mutations in Vibrio cholerae (1979) (39)
Repressor binding to a regulatory site in the DNA coding sequence is sufficient to confer transcriptional regulation of the vir-repressed genes (vrg genes) in Bordetella pertussis (1993) (38)
Structural analysis of the acfA and acfD genes of Vibrio cholerae: effects of DNA topology and transcriptional activators on expression (1992) (37)
Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient (2011) (37)
Decreased Potency of the Vibrio cholerae Sheathed Flagellum To Trigger Host Innate Immunity (2008) (37)
Use of Lambda Phage S and R Gene Products in an Inducible Lysis System for Vibrio cholerae- and Salmonella enterica Serovar Typhimurium-Based DNA Vaccine Delivery Systems (2000) (37)
Coupling mutagenesis and parallel deep sequencing to probe essential residues in a genome or gene (2013) (36)
Construction of a Vibrio cholerae Vaccine Candidate Using Transposon Delivery and FLP Recombinase-Mediated Excision (2000) (36)
Production and sequence validation of a complete full length ORF collection for the pathogenic bacterium Vibrio cholerae (2008) (35)
Rapid genetic analysis of Helicobacter pylori gastric mucosal colonization in suckling mice (2002) (35)
CTXΦ-independent production of the RS1 satellite phage by Vibrio cholerae (2003) (35)
Genetics of stress adaptation and virulence in toxigenic Vibrio cholerae. (2004) (34)
Cholera vaccines: fighting an ancient scourge. (1994) (34)
An onboard checking mechanism ensures effector delivery of the type VI secretion system in Vibrio cholerae (2019) (34)
Tracking Vibrio cholerae Cell-Cell Interactions during Infection Reveals Bacterial Population Dynamics within Intestinal Microenvironments. (2018) (33)
Genetic mapping of Vibrio cholerae enterotoxin structural genes (1984) (33)
Identification of Multiple ς54-Dependent Transcriptional Activators inVibrio cholerae (1998) (33)
Sigma E Regulators Control Hemolytic Activity and Virulence in a Shrimp Pathogenic Vibrio harveyi (2012) (33)
Affinity filters, a new approach to the isolation of tox mutants of Vibrio cholerae. (1978) (32)
Genomic characterization of nonO 1 , nonO 139 Vibrio cholerae reveals genes for a type III secretion system (2005) (32)
Determinants of the immunogenicity of live virulent and mutant Vibrio cholerae O1 in rabbit intestine (1987) (31)
Salmonella vaccines with mutations in the phoP virulence regulon. (1990) (31)
Alarmone Ap4A is elevated by aminoglycoside antibiotics and enhances their bactericidal activity (2019) (31)
Identification of multiple sigma54-dependent transcriptional activators in Vibrio cholerae. (1998) (30)
Determinants of immunogenicity and mechanisms of protection by virulent and mutant Vibrio cholerae O1 in rabbits (1988) (29)
Conjugate-like immunogens produced as protein capsular matrix vaccines (2015) (29)
An Open Letter to Elias Zerhouni (2005) (29)
Gut Check: Testing a Role for the Intestinal Microbiome in Human Obesity (2009) (26)
New attenuated derivatives of Vibrio cholerae. (1990) (26)
Isolation of Bdellovibrio and like organisms and potential to reduce acute hepatopancreatic necrosis disease caused by Vibrio parahaemolyticus. (2017) (26)
Identification of a pilus colonization factor that is coordinately regulated with cholera toxin. (1986) (25)
Vibrio cholerae Proteome-Wide Screen for Immunostimulatory Proteins Identifies Phosphatidylserine Decarboxylase as a Novel Toll-Like Receptor 4 Agonist (2009) (25)
Bacterial mucosal vaccines: Vibrio cholerae as a live attenuated vaccine/vector paradigm. (1999) (24)
Genomic science in understanding cholera outbreaks and evolution of Vibrio cholerae as a human pathogen. (2014) (22)
Measurement of transcriptional activity in pathogenic bacteria recovered directly from infected host tissue. (1994) (22)
Analysis of lipoprotein transport depletion in Vibrio cholerae using CRISPRi (2019) (21)
Broad-Host-Range Vectors forDelivery ofTnphoA:UseinGenetic Analysis ofSecreted Virulence Determinants ofVibrio cholerae (1989) (21)
Bacteriophage P22 transduction of integrated plasmids: single-step cloning of Salmonella typhimurium gene fusions (1993) (21)
Live cholera vaccines: perspectives on their construction and safety (1995) (21)
Molecular mechanisms of virstatin resistance by non‐O1/non‐O139 strains of Vibrio cholerae (2007) (21)
Live bacterial vaccines: environmental aspects. (1994) (19)
Diminished Diarrheal Response to Vibrio choleraeStrains Carrying the Replicative Form of the CTXΦ Genome instead of CTXΦ Lysogens in Adult Rabbits (2001) (18)
Morphological and physical characterization of the capsular layer of Vibrio cholerae O139 (1998) (18)
Live Attenuated Vaccine Vectors (1994) (18)
Simple method for purifying choleragenoid, the natural toxoid of Vibrio cholerae (1977) (18)
The Cyclic AMP (cAMP)-cAMP Receptor Protein Signaling System Mediates Resistance of Vibrio cholerae O1 Strains to Multiple Environmental Bacteriophages (2010) (17)
ToxR co‐operative interactions are not modulated by environmental conditions or periplasmic domain conformation (1999) (17)
Production and purification of cholera toxin. (1988) (17)
Endogenous membrane stress induces T6SS activity in Pseudomonas aeruginosa (2020) (17)
Regulation of cholera toxin production in Vibrio cholerae: genetic analysis of phenotypic instability in hypertoxinogenic mutants (1980) (16)
Regulation of Cholera Toxin Synthesis (1990) (16)
[24] Production and purification of cholera toxin (1988) (16)
1 2 , 3-Butanediol Synthesis and the Emergence of the Vibrio cholerae (2006) (16)
RS1 Satellite Phage Promotes Diversity of Toxigenic Vibrio cholerae by Driving CTX Prophage Loss and Elimination of Lysogenic Immunity (2014) (16)
Bacterial mucosal vaccines. (1992) (15)
Development of vaccines against cholera and diarrhoea due to enterotoxigenic Escherichia coli: Memorandum from a WHO meeting (1990) (15)
Pathogens and hosts: the dance is the same, the couples are different. (2000) (15)
Helicobacter pylori mutagenesis by mariner in vitro transposition. (2001) (14)
Mobile genetic elements and the evolution of new epidemic strains of Vibrio cholerae (1998) (14)
A plant virus HIV-1 chimera stimulates antibody that neutralizes HIV-1 (1996) (13)
Regulation of Cholera Toxin Expression (1994) (13)
Chromosomal DNA contains the gene coding for Salmonella enterotoxin (1987) (12)
Reversion of recombinant toxoids: mutations in diphtheria toxin that partially compensate for active-site deletions. (1992) (12)
Non-O1 Vibrio cholerae unlinked to cholera in Haiti (2012) (12)
Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling (2020) (11)
Sensing of intracellular Hcp levels controls T6SS expression in Vibrio cholerae (2021) (10)
Vaccine Economics: What Price Human Life? (2013) (10)
Correction: Sigma E Regulators Control Hemolytic Activity and Virulence in a Shrimp Pathogenic Vibrio harveyi (2012) (10)
Long-term Persistence of an Extensively Drug Resistant Subclade of Globally Distributed Pseudomonas aeruginosa Clonal Complex 446 in an Academic Medical Center. (2019) (9)
An experimental study of phage mediated bactericidal selection & emergence of the El Tor Vibrio cholerae (2011) (9)
Construction of cholera toxin B subunit-producing Vibrio cholerae strains using the Mariner-FRT transposon delivery system. (2008) (9)
Part I Overview (2006) (8)
17 – Progress toward Live-Attenuated Cholera Vaccines (1996) (8)
Identification of a bacteriophage containing a silent staphylococcal variant enterotoxin gene (sezA+) (1990) (7)
Mucosal Immunity: The Role of Secretory Immunoglobulin a in Protection Against the Invasive Pathogen Salmonella typhimurium (1993) (7)
Construction of a Vibrio cholerae prototype vaccine strain O395-N1-E1 which accumulates cell-associated cholera toxin B subunit. (2008) (7)
The Evolution of Vibrio cholerae as a Pathogen (2011) (6)
Vibrio parahaemolyticus and Its Specific Bacteriophages as an Indicator in Cockles (Anadara granosa) for the Risk of V. parahaemolyticus Infection in Southern Thailand (2014) (6)
Detection of NAD:arginine ADPribosyltransferases in animal tissues using 125I-labeled 1-(p-hydroxyphenyl) 2-guanidinoethane as ADPribose acceptor. (1985) (6)
Analysis of transmembrane dynamics of cholera toxin using photoreactive probes. (1979) (6)
Identification and use of protective monoclonal IgA antibodies against viral and bacterial pathogens. (1991) (5)
TCP Pilus Expression and Biogenesis by Classical and El Tor Biotypes of Vibrio Cholerae 01 (1989) (4)
CHAPTER 4 – Strategies to Identify Bacterial Pathogenicity Factors (2001) (4)
Modification of an agar well diffusion technique to isolate yeasts that inhibit Vibrio parahaemolyticus , the causative agent of acute hepatopancreatic necrosis disease (2018) (3)
A Potent Inhibitor of the Cystic Fibrosis Transmembrane Conductance Regulator Blocks Disease and Morbidity Due to Toxigenic Vibrio cholerae (2022) (3)
Strategies for the Development of Vaccines for Typhoid Fever, Shigellosis, and Cholera (1989) (3)
Bacterial cGAS-like enzymes synthesize diverse nucleotide signals (2019) (3)
Enzymic Activity of Cholera Toxin TO PROTEOLYTIC PROCESSING, DISULFIDE BOND REDUCTION, AND SUBUNIT (2002) (3)
A phase 1 randomized safety, reactogenicity, and immunogenicity study of Typhax: A novel protein capsular matrix vaccine candidate for the prevention of typhoid fever (2020) (3)
In vitro characterization and preclinical immunogenicity of Typhax, a typhoid fever protein capsular matrix vaccine candidate (2019) (3)
Cholera toxin promotes pathogen acquisition of host-derived nutrients (2019) (3)
Role of Transepithelial Transport in Triggering a Mucosal Immune Response and in Delivery of Mucosal Antibodies into Secretions (1992) (2)
Cell density-dependent death triggered by viral palindromic DNA sequences (2022) (2)
Six HIV-1 gp120-specific monoclonal antibodies exhibit two mechanisms of neutralization: Inhibition of attachment to the CD4 receptor is not one of them (1996) (2)
Intratumoral injection of schwannoma with attenuated Salmonella typhimurium induces antitumor immunity and controls tumor growth (2022) (2)
Protein covariance networks reveal interactions important to the emergence of SARS coronaviruses as human pathogens (2020) (2)
Bacterial response to host signals: analysis and applications. (1993) (2)
Transcriptional Silencing by TsrA in the Evolution of Pathogenic Vibrio cholerae Biotypes (2020) (1)
Diminished Diarrheal Response to Vibrio cholerae Strains Carrying the Replicative Form of the CTX (cid:2) Genome instead of CTX (cid:2) Lysogens in Adult Rabbits (2001) (1)
Covariance predicts conserved protein residue interactions important to the emergence and continued evolution of SARS-CoV-2 as a human pathogen (2022) (1)
Tackling Multidrug Resistance by Targeting Efflux in Pseudomonas aeruginosa (2015) (1)
A high-throughput sequencing approach identifies immunotherapeutic targets for bacterial meningitis in neonates (2022) (1)
Draft Genome Sequence of Pseudomonas aeruginosa Strain BWH047, a Sequence Type 235 Multidrug-Resistant Clinical Isolate Expressing High Levels of Colistin Resistance (2019) (1)
IronRegulation ofShiga-Like ToxinExpression inEscherichia coli IsMediated bythefurLocus (1987) (1)
Evolution of Vibrio cholerae and Cholera Epidemics (2008) (1)
Live Attenuated Cholera Vaccines: Flagella and Reactogenicity (2011) (1)
Genetic Analysis of Regulation and Structure of Shiga-Like Toxin I in Escherichia Coli (1990) (1)
Epidemic Potential for Origination of New Strains with : Molecular Basis Φ Susceptibility to CTX for Strains of Nontoxigenic Vibrio cholerae Analysis of Clinical and Environmental (2013) (1)
Synthetic peptides that form nanostructured micelles have potent antibiotic and antibiofilm activity against polymicrobial infections. (2023) (0)
Cloning andExpression oftheSalmonella Enterotoxin Gene (1987) (0)
In This Issue (2006) (0)
Isolation of enterotoxin structural I Vibrio cholerae induced by two muta (cholera toxin mutants/mutagenic bacteriophages/live oral,vaccines) (2016) (0)
Structure of Elizabethkingia meningoseptica CdnE cyclic dinucleotide synthase with GTP and Apcpp (2019) (0)
Structure of Rhodothermus marinus CdnE c-UMP-AMP synthase with Apcpp and Upnpp (2019) (0)
Live recombinant adenovirus expressing SIV Gag protein as an immunogen in mice (1997) (0)
Structure of Elizabethkingia meningoseptica CdnE cyclic dinucleotide synthase with pppA[3'-5']pA (2019) (0)
MICHAEL J. MAHAN*tt, JOHN W. TOBIAS*, JAMES M. SLAUCH*?, PHILIP C. HANNA*, R. JOHN COLLIER*, (2016) (0)
Microbiota-targeted maternal antibodies protect neonates from enteric infection (2020) (0)
Final announcement and call for poster abstracts (2004) (0)
Cholera: a paradigm for understanding emergence, virulence and temporal patterns of disease (2009) (0)
Structure of Acinetobacter baumannii Cap4 SAVED/CARF-domain containing receptor with the cyclic trinucleotide 3'3'3'-cAAA (2020) (0)
Central spike proteins of contractile ejection systems (2014) (0)
by high-density pyrosequencing and transposon mutagenesis pathogenesis revealed Acinetobacter baumannii New insights into (2007) (0)
Structure of Moraxella osloensis Cap4 SAVED/CARF-domain containing receptor (2020) (0)
Decision letter: Dominant Vibrio cholerae phage exhibits lysis inhibition sensitive to disruption by a defensive phage satellite (2019) (0)
Process for the preparation of a genetically stable mutant strain of vibrio cholerae. (1993) (0)
Vibrio parahaemolyticus and Its Specific Bacteriophages as an Indicator in Cockles (Anadara granosa) for the Risk of V. parahaemolyticus Infection in Southern Thailand (2014) (0)
The human pathogen Pseudo utilizes conserved virulence ( the social amoeba Dictyostel (2016) (0)
Construction of a Vibrio cholerae Vaccine Candidate Strain O395-N1-E1 which Accumulates Cell-associated Cholera Toxin B Subunit (2012) (0)
Φ Vibrio mimicus Strains by CTX Lysogenic Conversion of Environmental (2013) (0)
147. Identification of Novel Colistin Resistance Genes in an Extremely Colistin Resistant Pseudomonas aeruginosa Clinical Isolate (2022) (0)
Mougous Secretion Apparatus Encodes a Protein Pseudomonas aeruginosa A Virulence Locus of (2012) (0)
2453. Prolonged Local Epidemic of an XDR P. aeruginosa Subclade of High-Risk Clonal Complex 298 (2019) (0)
DNA, polypeptide, cell, composition and vaccines against diphtheria toxin. (1993) (0)
Covariance predicts conserved protein residue interactions important for the emergence and continued evolution of SARS-CoV-2 as a human pathogen (2022) (0)
Structure of Rhodothermus marinus CdnE c-UMP-AMP synthase (2019) (0)
Draft Genome Sequence of Vibrio parahaemolyticus PSU5579, Isolated during an Outbreak of Acute Hepatopancreatic Necrosis Disease in Thailand (2023) (0)
Isolation and identification of marine yeasts antagonize Vibrio parahaemolyticus causing acute hepatopancreatic necrosis disease (2018) (0)
Deletion mutants as vaccines against cholera (1993) (0)
The pathogenesis and immunology of vibrio cholerae and bordetella pertussis (2004) (0)
Microbiome induced complement synthesized in the gut protects against enteric infections (2023) (0)
Bacterial Cell-to-Cell Communication: Quorum-sensing-mediated regulation of biofilm growth and virulence of Vibrio cholerae (2006) (0)
Draft Genome Sequence of Bowmanella denitrificans JL63, a Bacterium Isolated from Whiteleg Shrimp (Litopenaeus vannamei) That Can Inhibit the Growth of Vibrio parahaemolyticus (2018) (0)
Vaccines against diphtheria toxin (1993) (0)
Structure of Acinetobacter baumannii Cap4 SAVED/CARF-domain containing receptor (2020) (0)
Molecular analysis of toxigenic vibrio cholerae strains isolated in Bangladesh during 1961-1996: relationship between continual emergence of new toxigenic clones and epidemics of cholera (1998) (0)
Interactions Between Bacterial Taxa Mediated by Type VI Secretion (2014) (0)
SYMPOSIUM ON TOXINS Proceedings of the 38th Symposium on Toxins held at Nagoya, on August 1 -3,1991. Director: AkioMIYAMA (2009) (0)
Infant Rabbit Colonization Competition Assays. (2014) (0)
Identification of a Vibrio cholera tightly linked to the cholera toxil (2016) (0)
Structure of Acinetobacter baumannii Cap4 SAVED/CARF-domain containing receptor with the cyclic trinucleotide 2'3'3'-cAAA (2020) (0)
Identification of a novel bacterial immunostimulatory protein and its application for the development of a vaccine adjuvant (2009) (0)
Modulation of Horizontal Gene Minireview Transfer in Pathogenic Bacteria by In Vivo Signals (1996) (0)

This paper list is powered by the following services:

Other Resources About John Mekalanos

en.wikipedia.org

What Schools Are Affiliated With John Mekalanos?

John Mekalanos is affiliated with the following schools: