John Moult

John Moult's AcademicInfluence.com Rankings

John Moult

Biology

#9787

World Rank

#13034

Historical Rank

Genetics

#1009

World Rank

#1107

Historical Rank

biology Degrees

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Biology

John Moult's Degrees

Masters Biotechnology Stanford University

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John Moult's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

SNPs, protein structure, and disease (2001) (715)
Critical assessment of methods of protein structure prediction (CASP)—round IX (2011) (687)
CAPRI: A Critical Assessment of PRedicted Interactions (2003) (618)
Genetic algorithms for protein folding simulations. (1992) (561)
The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses. (2005) (499)
A decade of CASP: progress, bottlenecks and prognosis in protein structure prediction. (2005) (487)
A large‐scale experiment to assess protein structure prediction methods (1995) (473)
SNPs3D: Candidate gene and SNP selection for association studies (2006) (468)
An all-atom distance-dependent conditional probability discriminatory function for protein structure prediction. (1998) (465)
Loss of protein structure stability as a major causative factor in monogenic disease. (2005) (419)
Critical assessment of methods of protein structure prediction (CASP) — round x (2014) (410)
Completeness in structural genomics (2001) (356)
Critical assessment of methods of protein structure prediction (CASP)—Round XII (2018) (345)
Critical assessment of methods of protein structure prediction—Round VII (2007) (342)
Critical assessment of methods of protein structure prediction (CASP)‐round V (2005) (329)
Critical assessment of methods of protein structure prediction (CASP)—Round XIII (2019) (319)
Processing and analysis of CASP3 protein structure predictions (1999) (309)
Critical assessment of methods of protein structure prediction (CASP): Round II (1997) (276)
A model for the Ca2+-induced conformational transition of troponin C. A trigger for muscle contraction. (1986) (270)
Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008 (2009) (269)
Bacterial resistance to beta-lactam antibiotics: crystal structure of beta-lactamase from Staphylococcus aureus PC1 at 2.5 A resolution. (1987) (268)
Identification and analysis of deleterious human SNPs. (2006) (265)
An algorithm for determining the conformation of polypeptide segments in proteins by systematic search (1986) (246)
Critical assessment of methods of protein structure prediction: Progress and new directions in round XI (2016) (220)
Analysis of the steric strain in the polypeptide backbone of protein molecules (1991) (206)
Progress over the first decade of CASP experiments (2005) (194)
Critical assessment of methods of protein structure prediction—Round VIII (2009) (184)
Stochastic noise in splicing machinery (2009) (182)
Critical assessment of methods of protein structure prediction (CASP): Round IV (2003) (170)
Finding the lowest free energy conformation of a protein is an NP-hard problem: proof and implications. (1993) (169)
A graph-theoretic algorithm for comparative modeling of protein structure. (1998) (165)
Protein folding simulations with genetic algorithms and a detailed molecular description. (1997) (153)
Evaluation of template‐based models in CASP8 with standard measures (2009) (153)
Processing and evaluation of predictions in CASP4 (2001) (150)
Assessment of protein disorder region predictions in CASP10 (2014) (145)
Computer simulation of the solvent structure around biological macromolecules (1978) (137)
Comparison of systematic search and database methods for constructing segments of protein structure. (1994) (134)
Genetic Algorithm for 3D Protein Folding Simulations (1993) (133)
Critical assessment of methods of protein structure prediction (CASP)—Round XIV (2021) (131)
Critical assessment of methods of protein structure prediction (CASP): round III. (1997) (130)
Outcome of a workshop on applications of protein models in biomedical research. (2009) (129)
Role of electrostatic screening in determining protein main chain conformational preferences. (1995) (128)
Assessment of progress over the CASP experiments (2003) (128)
Distance measurement and structure refinement with NOE data (1990) (125)
Comparison of database potentials and molecular mechanics force fields. (1997) (123)
CASP9 results compared to those of previous casp experiments (2011) (121)
Evaluation of disorder predictions in CASP9 (2011) (117)
Biological function made crystal clear - annotation of hypothetical proteins via structural genomics. (2000) (115)
Genetic algorithms for protein structure prediction. (1996) (113)
An analysis of protein folding pathways. (1991) (107)
Critical assessment of methods of protein structure prediction (CASP)—Round 6 (2005) (106)
A unifold, mesofold, and superfold model of protein fold use (2002) (105)
Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics. (2008) (103)
Proteopedia - a scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromolecules (2008) (102)
CASP10 results compared to those of previous CASP experiments (2014) (101)
Docking by least-squares fitting of molecular surface patterns. (1992) (98)
Evaluation of disorder predictions in CASP5 (2003) (96)
Local interactions dominate folding in a simple protein model. (1996) (94)
Towards computing with proteins (2006) (91)
Critical assessment of methods of protein structure prediction (CASP): round IV. (2001) (86)
Comparison of performance in successive CASP experiments (2001) (86)
Electrostatics (1992) (83)
Probing the calcium-induced conformational transition of troponin C with site-directed mutants (1990) (82)
The structure of triclinic lysozyme at 2-5 A resolution. (1976) (82)
Predicting protein three-dimensional structure. (1999) (78)
Progress from CASP6 to CASP7 (2007) (73)
From fold to function. (2000) (70)
GWAS and drug targets (2014) (70)
Chaos in protein dynamics (1997) (68)
Construction and characterization of a spectral probe mutant of troponin C: application to analyses of mutants with increased Ca2+ affinity. (1992) (61)
Outcome of a workshop on archiving structural models of biological macromolecules. (2006) (59)
Some measures of comparative performance in the three CASPs (1999) (54)
The current state of the art in protein structure prediction. (1996) (54)
A bacteriophage endolysin that eliminates intracellular streptococci (2016) (52)
Evaluation of the template‐based modeling in CASP12 (2018) (51)
CASP8 results in context of previous experiments (2009) (49)
Molecular dynamics study of the structure and dynamics of a protein molecule in a crystalline ionic environment, Streptomyces griseus protease A. (1990) (49)
Molecular modeling of protein function regions (2004) (49)
Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th Critical Assessment of Techniques for Protein Structure Prediction Experiment CASP10 (2014) (48)
A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity. (2009) (47)
pKa Shifts in Small Molecules and HIV Protease: Electrostatics and Conformation (1998) (47)
Reports from CAGI: The Critical Assessment of Genome Interpretation (2017) (47)
Mapping genetic variations to three-dimensional protein structures to enhance variant interpretation: a proposed framework (2017) (46)
Rigorous performance evaluation in protein structure modelling and implications for computational biology (2006) (46)
Determinants of side chain conformational preferences in protein structures. (1998) (44)
Structural and functional impact of cancer-related missense somatic mutations. (2011) (43)
Crystallographic studies of protein denaturation and renaturation. 1. Effects of denaturants on volume and X-ray pattern of cross-linked triclinic lysozyme crystals. (1977) (43)
Electron density calculations as an extension of protein structure refinement. Streptomyces griseus protease A at 1.5 A resolution. (1983) (42)
Crystal structure of demetallized concanavalin A: the metal-binding region. (1979) (42)
Determination of the conformation of folding initiation sites in proteins by computer simulation (1995) (41)
Genetic Basis of Common Human Disease: Insight into the Role of Missense SNPs from Genome-Wide Association Studies. (2015) (41)
Finding the lowest free energy conformation of a protein is an NP-hard problem: Proof and implications (1993) (41)
Working toward precision medicine: Predicting phenotypes from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges (2017) (36)
Structural implication of splicing stochastics (2009) (36)
Reports from the fifth edition of CAGI: The Critical Assessment of Genome Interpretation (2019) (35)
Insights from GWAS: emerging landscape of mechanisms underlying complex trait disease (2015) (35)
Critical assessment of methods of protein structure prediction (CASP): Round III (1999) (33)
On achieving better than 1-A accuracy in a simulation of a large protein: Streptomyces griseus protease A. (1993) (33)
Dielectric Screening Treatment of Electrostatic Solvation (1997) (33)
Comparative modeling in structural genomics. (2008) (32)
Three‐dimensional structural location and molecular functional effects of missense SNPs in the T cell receptor Vβ domain (2003) (31)
Protein stability and in vivo concentration of missense mutations in phenylalanine hydroxylase (2012) (30)
Penicillin-binding and degrading enzymes (1991) (30)
Troponin-C mutants with increased calcium affinity. (1993) (30)
Protein family clustering for structural genomics. (2005) (30)
Elimination of the hydrolytic water molecule in a class A beta-lactamase mutant: crystal structure and kinetics. (1996) (29)
Binding of divalent copper ions to aspartic acid residue 52 in hen egg-white lysozyme. (1974) (29)
Consensus Genome-Wide Expression Quantitative Trait Loci and Their Relationship with Human Complex Trait Disease. (2016) (28)
Comparison of the chemical and thermal denaturation of proteins by a two-state transition model. (2008) (28)
Protein Characterization of a Candidate Mechanism SNP for Crohn's Disease: The Macrophage Stimulating Protein R689C Substitution (2011) (28)
Ab initio protein folding simulations with genetic algorithms: Simulations on the complete sequence of small proteins (1997) (27)
Low Frequency Motion in Proteins (1999) (27)
Monte carlo simulation of the solvent structure in crystals of a hydrated cyclic peptide (1980) (26)
Increasing the stability of the bacteriophage endolysin PlyC using rationale-based FoldX computational modeling. (2015) (26)
Protein design on computers. Five new proteins: Shpilka, grendel, fingerclasp, leather, and aida (1992) (23)
Progress from CASP 6 to CASP 7 (2007) (22)
Structural basis for the mechanism and substrate specificity of glycocyamine kinase, a phosphagen kinase family member. (2010) (22)
Positive and negative cooperativities at subsequent steps of oxygenation regulate the allosteric behavior of multistate sebacylhemoglobin. (1996) (21)
The identification by x-ray crystallography of the site of attachment of an affinity label to hen egg-white lysozyme. (1973) (21)
Confronting the problem of interconnected structural changes in the comparative modeling of proteins (1995) (21)
Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction (2011) (20)
Composition bias and the origin of ORFan genes (2010) (19)
Detection of operons (2006) (19)
Molecular structure of troponin C and its implications for the Ca2+ triggering of muscle contraction. (1987) (18)
Crystallographic, molecular modeling, and biophysical characterization of the valine beta 67 (E11)-->threonine variant of hemoglobin. (1996) (18)
We need both computer models and experiments (2001) (18)
Ensemble variant interpretation methods to predict enzyme activity and assign pathogenicity in the CAGI4 NAGLU (Human N‐acetyl‐glucosaminidase) and UBE2I (Human SUMO‐ligase) challenges (2017) (16)
Calcium binding to skeletal muscle troponin C and the regulation of muscle contraction. (2007) (16)
The crystal structure of beta-lactamase from Staphylococcus aureus at 0.5 nm resolution. (1985) (15)
Low Frequency Motion in Proteins Comparison of Normal Mode and Molecular Dynamics of Streptomyces Griseus Protease A (1999) (13)
Target highlights in CASP14: Analysis of models by structure providers (2021) (13)
Computational models in the service of X‐ray and cryo‐electron microscopy structure determination (2021) (13)
Assessment of methods for predicting the effects of PTEN and TPMT protein variants (2019) (13)
Some of the most interesting CASP11 targets through the eyes of their authors (2015) (12)
Matching phenotypes to whole genomes: Lessons learned from four iterations of the personal genome project community challenges (2017) (11)
Modeling SARS‐CoV‐2 proteins in the CASP‐commons experiment (2021) (11)
CAGI4 Crohn's exome challenge: Marker SNP versus exome variant models for assigning risk of Crohn disease (2017) (11)
The crystal packing interactions of two different crystal forms of bovine Ribonuclease A (1991) (11)
Harnessing formal concepts of biological mechanism to analyze human disease (2018) (11)
Predicting venous thromboembolism risk from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges (2019) (11)
Performance of in silico tools for the evaluation of p16INK4a (CDKN2A) variants in CAGI (2017) (10)
CAGI4 SickKids clinical genomes challenge: A pipeline for identifying pathogenic variants (2017) (10)
CAGI SickKids challenges: Assessment of phenotype and variant predictions derived from clinical and genomic data of children with undiagnosed diseases (2019) (10)
Protein structure prediction (2000) (10)
Electrostatics: Current Opinion in Structural Biology 1992, 2:223–229 (1992) (10)
The Product Guides the Process: Discovering Disease Mechanisms (2018) (9)
CACHE (Critical Assessment of Computational Hit-finding Experiments): A public–private partnership benchmarking initiative to enable the development of computational methods for hit-finding (2021) (9)
A system view and analysis of essential hypertension (2018) (9)
Genetic basis of common human disease: insight into the role of nonsynonymous SNPs from genome-wide association studies (2011) (9)
Fitting electron density by systematic search. (1992) (9)
Assisting functional assignment for hypothetical Heamophilus influenzae gene products through structural genomics. (2002) (9)
Comparative Modeling of Protein Structure—Progress and Prospects (1989) (9)
Structure, dynamics and energetics of initiation sites in protein folding: I. Analysis of a 1 ns molecular dynamics trajectory of an early folding unit in water: the helix I/loop I-fragment of barnase. (1995) (9)
An algorithm which predicts the conformation of short lengths of chain in proteins (1986) (8)
The effect of binding of metal ions on the three‐dimensional structure of demetallized concanavalin A (1978) (8)
Performance of computational methods for the evaluation of pericentriolar material 1 missense variants in CAGI‐5 (2019) (8)
Target highlights in CASP13: Experimental target structures through the eyes of their authors (2019) (8)
Assessment of patient clinical descriptions and pathogenic variants from gene panel sequences in the CAGI‐5 intellectual disability challenge (2019) (7)
The significance of performance ranking in CASP--response to Marti-Renom et al. (2002) (7)
Target highlights from the first post‐PSI CASP experiment (CASP12, May–August 2016) (2018) (7)
Conformation of the sebacyl β1Lys82–β2Lys82 crosslink in T‐state human hemoglobin (1998) (6)
Structural analysis of denaturant-protein interactions: Comparison between the effects of bromoethanol and SDS on denaturation and renaturation of triclinic lysozyme (1978) (6)
Effects of Mutations on the Performance of Genetic Algorithms Suitable for Protein Folding Simulations (1993) (6)
Assessing computational predictions of the phenotypic effect of cystathionine‐beta‐synthase variants (2019) (6)
Matching whole genomes to rare genetic disorders: Identification of potential causative variants using phenotype-weighted knowledge in the CAGI SickKids5 clinical genomes challenge (2019) (6)
Crystallographic Analysis of a Pepstatin Analogue Binding to the Aspartyl Proteinase Penicillopepsin at 1.8 Angstroms Resolution (1994) (5)
Assessment of predicted enzymatic activity of α‐N‐acetylglucosaminidase variants of unknown significance for CAGI 2016 (2019) (5)
Lessons from the CAGI‐4 Hopkins clinical panel challenge (2017) (5)
CASP: A Driving Force in Protein Structure Modeling (2010) (4)
Local electrostatic optimization in proteins. (1999) (4)
Iatrogenic hypertension: a bioinformatic analysis (2018) (3)
Determination of disease phenotypes and pathogenic variants from exome sequence data in the CAGI 4 gene panel challenge (2017) (3)
Community-wide assessment of GPCR structure modeling and docking understanding (2009) (3)
Neighbor Overlap Is Enriched in the Yeast Interaction Network: Analysis and Implications (2012) (2)
Conformation of the sebacyl beta1Lys82-beta2Lys82 crosslink in T-state human hemoglobin. (1998) (2)
CONFORMATIONAL FLEXIBILITY OF TROPONIN C11Supported by the Medical Research Council of Canada, an Alberta Heritage Foundation of Medical Research Fellowship (to O.H.) and an Alberta Heritage Foundation for Medical Research Visiting Scientist Fellowship (to J.M.). (1987) (2)
MecCog: A knowledge representation framework for genetic disease mechanism (2020) (2)
Characterizing and comparing missense variants in monogenic disease and in cancer (2019) (2)
Computational models in the service of X-ray and cryo-EM structure determination (2021) (2)
The crystal structure of p-nitrophenyl-β-D-N-acetylglucosaminide monohydrate (1975) (2)
Matching whole genomes to rare genetic disorders: Identification of potential causative variants using phenotype‐weighted knowledge in the CAGI SickKids5 clinical genomes challenge (2020) (1)
Simulation of the crystal of streptomyces griseus protease a (1988) (1)
A tribute to Anna Tramontano (1957–2017) (2018) (1)
Analysis and prediction of solvent structures in protein crystals (1984) (1)
Joint analysis of genome-wide genetic variants associated with gene expression and disease susceptibility (2011) (1)
Insights from GWAS: emerging landscape of mechanisms underlying complex trait disease (2015) (1)
Why genetic algorithms are suitable for protein folding analysis: the theoretical foundations (1992) (1)
Genetic basis of common human disease: insight into the role of nonsynonymous SNPs from genome-wide association studies (2011) (1)
Crystallographic studies of the active site of lysozyme. In: Molecular properties of drug receptors. (1970) (1)
CAGI: The critical assessment of genome interpretation, a community experiment to evaluate phenotype prediction (2020) (1)
On the computational complexity of protein folding (1992) (1)
Computational structural biology in the era of deep learning. (2023) (0)
FliD , the flagellar cap protein from Pseudomonas aeruginosa PAO 1 ( CASP : T 0886 , Ts 886 , PDB : 5 FHY ) : Provided by (2017) (0)
GWAS and drug targets (2014) (0)
Elucidating the mechanism of β-lactamase by crystallographic studies (1993) (0)
Abstract LB-250: The Critical Assessment of Genome Interpretation: A community experiment that informs use of methods for germline cancer variant impact prediction (2020) (0)
Joint analysis of genome-wide genetic variants associated with gene expression and disease susceptibility (2011) (0)
REFINED CRYSTAL STRUCTURE OF BETA-LACTAMASE FROM STAPHYLOCOCCUS AUREUS PC1 AT 2.0 (1991) (0)
Mapping genetic variations to three-dimensional protein structures to enhance variant interpretation: a proposed framework (2017) (0)
Measurements of some Dusuns (0)
Novel Antibody Interfaces Revealed Through Structural Mining (2022) (0)
Theoretical Studies of the Energetics and Dynamics of the Aqueous and Ionic Environment about Proteins: Crystals of Streptomyces Griseus Protease A (1989) (0)
Author response for "Modeling SARS‐CoV2 proteins in the CASP ‐commons experiment" (2021) (0)
Infrastructure for Collaborative Protein Structure Prediction (2006) (0)
Crystal structure of -lactamase from Staphylococcus aureus PC1 at 2.5 Ã resolution (1987) (0)
Iatrogenic hypertension: a bioinformatic analysis (2018) (0)
Issue Information (2019) (0)
Comparison of Monte Carlo and genetic algorithm methods for folding peptides (1993) (0)
Author response: A bacteriophage endolysin that eliminates intracellular streptococci (2016) (0)
Proteopedia: scientific wiki bridging 3D structure-function (2009) (0)
An accurate simulation of the protein Streptomyces griseus protease A (1993) (0)
Improved force fields for the simulation of peptides and proteins (1993) (0)
Chasing the function of hypothetical proteins (2005) (0)
Antibody interfaces revealed through structural mining (2022) (0)
Prediction of the conformation of short segments of polypeptide chain in proteins (1987) (0)
Reply to HU et al.: On the interpretation of gasdermin-B expression quantitative trait loci data (2017) (0)
Back Cover, Volume 40, Issue 9 (2019) (0)
Molecular Reorientation in an Electric Field as Studied by Single-Crystal X-ray Diffraction (1992) (0)
The past, present and future of protein structure prediction (abstract) (1999) (0)
Cover Image, Volume 87, Issue 12 (2019) (0)

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What Schools Are Affiliated With John Moult?

John Moult is affiliated with the following schools:

University of Maryland, College Park
University of Alberta
Stanford University