John Olney
American medical doctor and neuropathologist
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Biology Philosophy
John Olney's Degrees
- Doctorate Medicine Harvard University
- PhD Neuroscience Stanford University
Why Is John Olney Influential?
(Suggest an Edit or Addition)According to Wikipedia, John Olney was a medical doctor and a professor of psychiatry, pathology, and immunology at the Washington University School of Medicine. He is known for his work on brain damage. He coined the term excitotoxicity in his 1969 paper published in Science. Olney's lesions are named after him. In 1996 he was elected to the Institute of Medicine of the United States National Academy of Sciences. He had campaigned for greater regulation of monosodium glutamate , aspartame and other excitotoxins for over twenty years. He died at his residence on April 14, 2015 at the age of 83.
John Olney's Published Works
Published Works
- Glutamate and the pathophysiology of hypoxic–ischemic brain damage (1986) (2476)
- Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. (1999) (2015)
- Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate (1969) (1796)
- Glutamate receptor dysfunction and schizophrenia. (1995) (1678)
- Early Exposure to Common Anesthetic Agents Causes Widespread Neurodegeneration in the Developing Rat Brain and Persistent Learning Deficits (2003) (1552)
- Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome. (2000) (1348)
- Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. (1989) (1194)
- Excitotoxity and the NMDA receptor (1987) (1080)
- NMDA receptor hypofunction model of schizophrenia. (1999) (964)
- Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. (2000) (869)
- NMDA antagonist neurotoxicity: mechanism and prevention. (1991) (834)
- Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: A histological study (1980) (716)
- Antiepileptic drugs and apoptotic neurodegeneration in the developing brain (2002) (714)
- Kainic acid: a powerful neurotoxic analogue of glutamate. (1974) (707)
- Kainic acid as a tool in neurobiology (1978) (682)
- Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain (1995) (679)
- Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin (1998) (653)
- Ketamine-Induced NMDA Receptor Hypofunction as a Model of Memory Impairment and Psychosis (1999) (594)
- Excitotoxicity and the NMDA receptor - still lethal after eight years (1995) (572)
- Isoflurane-induced Neuroapoptosis in the Neonatal Rhesus Macaque Brain (2010) (506)
- Brain Lesions in an Infant Rhesus Monkey Treated with Monosodium Glutamate (1969) (492)
- Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain (2005) (451)
- Excitotoxic mechanisms of epileptic brain damage. (1986) (423)
- GLUTAMATE‐INDUCED NEURONAL NECROSIS IN THE INFANT MOUSE HYPOTHALAMUS: An Electron Microscopic Study (1971) (414)
- Excitotoxic amino acids and neuropsychiatric disorders. (1990) (412)
- Propofol-induced apoptosis of neurones and oligodendrocytes in fetal and neonatal rhesus macaque brain. (2013) (393)
- Brain Damage in Infant Mice following Oral Intake of Glutamate, Aspartate or Cysteine (1970) (391)
- GLUTAMATE—INDUCED RETINAL DEGENERATION IN NEONATAL MICE. ELECTRON MICROSCOPY OF THE ACUTELY EVOLVING LESION (1969) (374)
- Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats. (1983) (365)
- The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures (1987) (356)
- Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. (2003) (325)
- The role of specific ions in glutamate neurotoxicity (1986) (309)
- Excitatory amino acids and neuropsychiatrie disorders (1989) (306)
- Ketamine-induced Neuroapoptosis in the Fetal and Neonatal Rhesus Macaque Brain (2012) (302)
- Neurotransmitters and apoptosis in the developing brain. (2001) (300)
- Acute dendrotoxic changes in the hippocampus of kainate treated rats (1979) (298)
- Ethanol-induced apoptotic neurodegeneration in the developing C57BL/6 mouse brain. (2002) (294)
- Drug‐induced Apoptotic Neurodegeneration in the Developing Brain (2002) (282)
- Neuronal Vacuolization and Necrosis Induced by the Noncompetitive N-methyl-d-aspartate (NMDA) Antagonist MK(+)801 (Dizocilpine Maleate): A Light and Electron Microscopic Evaluation of the Rat Retrosplenial Cortex (1993) (260)
- Subanesthetic Doses of Propofol Induce Neuroapoptosis in the Infant Mouse Brain (2008) (257)
- An electron microscopic study of synapse formation, receptor outer segment development, and other aspects of developing mouse retina. (1968) (254)
- L-cysteine, a bicarbonate-sensitive endogenous excitotoxin. (1990) (251)
- GLUTAMATE‐INDUCED BRAIN DAMAGE IN INFANT PRIMATES (1972) (250)
- Redox Modulation of T-Type Calcium Channels in Rat Peripheral Nociceptors (2001) (247)
- Isoflurane‐induced apoptosis of oligodendrocytes in the neonatal primate brain (2012) (242)
- Ethanol-Induced Caspase-3 Activation in the in Vivo Developing Mouse Brain (2002) (241)
- Apoptotic neurodegeneration following trauma is markedly enhanced in the immature brain (1999) (238)
- N-Methyl-D-aspartate antagonists and apoptotic cell death triggered by head trauma in developing rat brain. (1999) (226)
- Ketamine, Phencyclidine, and MK‐801 Protect Against Kainic Acid‐Induced Seizure‐Related Brain Damage (1990) (222)
- Age-specific neurotoxicity in the rat associated with NMDA receptor blockade: Potential relevance to schizophrenia? (1995) (220)
- Distinguishing excitotoxic from apoptotic neurodegeneration in the developing rat brain (1999) (215)
- Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system (2004) (209)
- Inciting excitotoxic cytocide among central neurons. (1986) (208)
- Effect of Nitrous Oxide on Excitatory and Inhibitory Synaptic Transmission in Hippocampal Cultures (1998) (206)
- Dimethyl sulfoxide (DMSO) produces widespread apoptosis in the developing central nervous system (2009) (205)
- Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain (2003) (199)
- A benzodiazepine recognition site associated with the non-NMDA glutamate receptor (1993) (197)
- “Epileptic” brain damage in rats induced by sustained electrical stimulation of the perforant path. II. Ultrastructural analysis of acute hippocampal pathology (1983) (190)
- NMDA Antagonists as Neurotherapeutic Drugs, Psychotogens, Neurotoxins, and Research Tools for Studying Schizophrenia (1995) (189)
- Seizure-related brain damage induced by cholinergic agents (1983) (187)
- Ethanol-induced neuroapoptosis in the developing rodent cerebellum and related brain stem structures. (2005) (185)
- Isoflurane-induced Apoptosis of Neurons and Oligodendrocytes in the Fetal Rhesus Macaque Brain (2014) (184)
- New insights and new issues in developmental neurotoxicology. (2002) (184)
- THE TOXIC EFFECTS OF GLUTAMATE AND RELATED COMPOUNDS IN THE RETINA AND THE BRAIN (1982) (182)
- Excitotoxic neurodegeneration in Alzheimer disease. New hypothesis and new therapeutic strategies. (1997) (180)
- Focal cortical seizures cause distant thalamic lesions. (1982) (174)
- Glutamate neurotoxicity and Huntington's chorea (1978) (174)
- Apoptosis in the in Vivo Mammalian Forebrain (2001) (169)
- Isoflurane-induced Neuroapoptosis in the Developing Brain of Nonhypoglycemic Mice (2008) (167)
- Behavioral Phenotyping of GFAP-ApoE3 and -ApoE4 Transgenic Mice: ApoE4 Mice Show Profound Working Memory Impairments in the Absence of Alzheimer's-like Neuropathology (2001) (164)
- The glutamate synapse in neuropsychiatric disorders. Focus on schizophrenia and Alzheimer's disease. (1998) (161)
- Excitotoxins: An Overview (1983) (160)
- The anti-excitotoxic effects of certain anesthetics, analgesics and sedative-hypnotics (1986) (159)
- A comparative evaluation of the neurotoxic properties of ketamine and nitrous oxide (2001) (154)
- Increased neocortical neurofibrillary tangle density in subjects with Alzheimer disease and psychosis. (2000) (154)
- NMDA receptor function, memory, and brain aging (2000) (151)
- Blockade of both NMDA and non-NMDA receptors is required for optimal protection against ischemic neuronal degeneration in the in vivo adult mammalian retina (1991) (150)
- Domoic acid: A dementia-inducing excitotoxic food poison with kainic acid receptor specificity (1990) (150)
- Ethanol-induced apoptotic neurodegeneration in the developing brain (2000) (149)
- Do pediatric drugs cause developing neurons to commit suicide? (2004) (149)
- MK-801 powerfully protects against N-methyl aspartate neurotoxicity. (1987) (147)
- Lithium Protects against Anesthesia-induced Developmental Neuroapoptosis (2009) (141)
- Environmental agents that have the potential to trigger massive apoptotic neurodegeneration in the developing brain. (2000) (141)
- Anesthesia-induced developmental neuroapoptosis. Does it happen in humans? (2004) (139)
- Prolonged exposure to inhalational anesthetic nitrous oxide kills neurons in adult rat brain (2003) (138)
- Excitotoxicity of l-DOPA and 6-OH-DOPA: Implications for Parkinson's and Huntington's diseases (1990) (137)
- Excitotoxicity, apoptosis and neuropsychiatric disorders. (2003) (134)
- Effects of lactate and pyruvate on glucose deprivation in rat hippocampal slices. (1994) (131)
- WALLERIAN DEGENERATION IN RABBIT OPTIC NERVE: CELLULAR LOCALIZATION IN THE CENTRAL NERVOUS SYSTEM OF THE S‐100 AND 14‐3‐2 PROTEINS 1 (1970) (129)
- Low Doses of Memantine Disrupt Memory in Adult Rats (2006) (129)
- Ketamine potentiates cerebrocortical damage induced by the common anaesthetic agent nitrous oxide in adult rats (2000) (127)
- CYSTEINE‐S‐SULFATE: BRAIN DAMAGING METABOLITE IN SULFITE OXIDASE DEFICIENCY1 (1975) (122)
- The Young: Neuroapoptosis Induced by Anesthetics and What to Do About It (2010) (120)
- Motor Neuron Degeneration Induced by Excitotoxin Agonists Has Features in Common with those Seen in the SOD-1 Transgenic Mouse Model of Amyotrophic Lateral Sclerosis (1996) (118)
- Role of caspase-3 in ethanol-induced developmental neurodegeneration (2005) (117)
- Anti-parkinsonian agents are phencyclidine agonists and N-methyl-aspartate antagonists. (1987) (115)
- Acute elevations of serum luteinizing hormone induced by kainic acid, N-methyl aspartic acid or homocysteic acid. (1978) (114)
- Acute neonatal glucocorticoid exposure produces selective and rapid cerebellar neural progenitor cell apoptotic death (2008) (114)
- Multiple episodes of mild traumatic brain injury result in impaired cognitive performance in mice. (2004) (112)
- Excitatory amino acids and neuropsychiatric disorders. (1989) (111)
- Excitatory Amino Acid Receptor Potency and Subclass Specificity of Sulfur‐Containing Amino Acids (1987) (109)
- Multifocal brain damage induced by phencyclidine is augmented by pilocarpine (1997) (107)
- Fetal alcohol syndrome at the cellular level (2004) (106)
- L-Homocysteic acid: An endogenous excitotoxic ligand of the NMDA receptor (1987) (105)
- Kainate-like neurotoxicity of folates (1981) (104)
- Olanzapine and fluperlapine mimic clozapine in preventing MK-801 neurotoxicity (1996) (101)
- Neuroapoptosis in the infant mouse brain triggered by a transient small increase in blood alcohol concentration (2006) (101)
- Ketamine and MK-801 prevent degeneration of thalamic neurons induced by focal cortical seizures (1989) (100)
- Excitatory transmitters and epilepsy-related brain damage. (1985) (98)
- Hypothermia enhances protective effect of MK-801 against hypoxic/ischemic brain damage in infant rats (1989) (97)
- The enigma of fetal alcohol neurotoxicity (2002) (97)
- Antipsychotic drugs block phencyclidine receptor-mediated neurotoxicity (1993) (97)
- Quantitative analysis of factors influencing neuronal necrosis induced by MK-801 in the rat posterior cingulate/retrosplenial cortex (1995) (93)
- Delayed Excitotoxic Neurodegeneration Induced by Excitatory Amino Acid Agonists in Isolated Retina (1995) (93)
- Cathepsin D Deficiency Induces Persistent Neurodegeneration in the Absence of Bax-Dependent Apoptosis (2007) (93)
- Disseminated Corticolimbic Neuronal Degeneration Induced in Rat Brain by MK-801: Potential Relevance to Alzheimer's Disease (1998) (93)
- Acute glutamate-induced elevations in serum testosterone and luteinizing hormone (1976) (92)
- Age-related sensitivity to kainate neurotoxicity (1991) (92)
- Excitotoxic Cytopathology, Progression, and Reversibility of Thiamine Deficiency‐induced Diencephalic Lesions (1995) (90)
- PRO: Anesthesia-induced developmental neuroapoptosis: status of the evidence. (2008) (87)
- Potential of xenon to induce or to protect against neuroapoptosis in the developing mouse brain (2008) (87)
- Glutamate transporters and retinal excitotoxicity (2002) (86)
- Cysteine-induced brain damage in infant and fetal rodents. (1972) (86)
- Excessive cerebrocortical release of acetylcholine induced by NMDA antagonists is reduced by GABAergic and α2-adrenergic agonists (1999) (86)
- MK-801 neurotoxicity in male mice: histologic effects and chronic impairment in spatial learning (1996) (86)
- Cerebral metabolic response to systemic kainic acid: 14-C-deoxyglucose studies. (1980) (85)
- Alcohol-induced neuroapoptosis in the fetal macaque brain (2010) (84)
- Müller cell swelling, glutamate uptake, and excitotoxic neurodegeneration in the isolated rat retina (1999) (82)
- Neurotoxic effects of glutamate on mouse area postrema (1977) (82)
- Excitatory transmitter neurotoxicity (1994) (81)
- Brain and retinal damage from lathyrus excitotoxin, β-N-oxalyl-L-α,β-diaminopropionic acid (1976) (81)
- ACCUMULATION OF GLUTAMIC ACID IN THE ARCUATE NUCLEUS OF THE HYPOTHALAMUS OF THE INFANT MOUSE FOLLOWING SUBCUTANEOUS ADMINISTRATION OF MONOSODIUM GLUTAMATE 1 (1972) (81)
- Photothrombosis-induced ischemic neuronal degeneration in the rat retina (1989) (79)
- Excitotoxic neuronal damage and neuropsychiatric disorders. (1993) (78)
- Serotonergic Agents That Activate 5HT2A Receptors Prevent NMDA Antagonist Neurotoxicity (1998) (78)
- Excitotoxins in foods. (1994) (77)
- Calcium influx accompanies but does not cause excitotoxin-induced neuronal necrosis in retina (1985) (75)
- Behavioral effects of MK-801 in the rat (1990) (75)
- Ethanol-induced apoptosis in the developing visual system during synaptogenesis. (2003) (75)
- CSF excitatory amino acids and severity of illness in Alzheimer's disease (1996) (74)
- Neuroactive amino acids influence gonadotrophin output by a suprapituitary mechanism in either rodents or primates (1983) (73)
- Uptake of Exogenous Glutamate and Aspartate by Circumventricular Organs but Not Other Regions of Brain (1981) (73)
- Prevention of Trauma-Induced Neurodegeneration in Infant Rat Brain (1996) (73)
- Stereospecificity of the gliotoxic and anti-neurotoxic actions of alpha-aminoadipate (1980) (73)
- Morphine analgesia potentiated but tolerance not affected by active immunization against cholecystokinin. (1984) (73)
- Excitotoxin-mediated neuron death in youth and old age. (1990) (72)
- New mechanisms of excitatory transmitter neurotoxicity. (1994) (72)
- Excitotoxic versus apoptotic mechanisms of neuronal cell death in perinatal hypoxia/ischemia. (2004) (71)
- Isoflurane exposure for three hours triggers apoptotic cell death in neonatal macaque brain (2017) (71)
- Cysteine oxidase in brain (1975) (69)
- Drugs of abuse that cause developing neurons to commit suicide. (2003) (69)
- The fate of synaptic receptors in the kainate-lesioned striatum (1978) (69)
- Efficacy of clozapine compared with other antipsychotics in preventing NMDA-antagonist neurotoxicity. (1994) (67)
- PDAPP; YFP double transgenic mice: A tool to study amyloid‐β associated changes in axonal, dendritic, and synaptic structures (2003) (67)
- Excitotoxic Cell Death Dependent on Inhibitory Receptor Activation (1999) (66)
- Glutamate signaling and the fetal alcohol syndrome. (2001) (65)
- Glycine agonists: what can they teach us about schizophrenia? (1999) (64)
- Ethanol causes and lithium prevents neuroapoptosis and suppression of pERK in the infant mouse brain (2008) (64)
- Excitotoxicity and N‐methyl‐D‐Aspartate receptors (1989) (63)
- Brain-damaging potential of protein hydrolysates. (1973) (63)
- D-aminaphosphonovalerate is 100-fold more powerful than D-alpha-aminoadipate in blocking N-methylaspartate neurotoxicity (1981) (62)
- Excitotoxicity: an overview. (1990) (61)
- Physiological Activity Depresses Synaptic Function through an Effect on Vesicle Priming (2006) (61)
- Effects of morphine or naloxone on kainic acid neurotoxicity. (1979) (60)
- Clonidine potentiates the neuropathic pain-relieving action of MK-801 while preventing its neurotoxic and hyperactivity side effects (1998) (60)
- Alcohol-induced apoptosis of oligodendrocytes in the fetal macaque brain (2013) (60)
- Status epilepticus in the limbic system: biochemical and pathological changes. (1983) (59)
- Halothane prevents MK-801 neurotoxicity in the rat cingulate cortex (1995) (58)
- Ca2+-independent excitotoxic neurodegeneration in isolated retina, an intact neural net: a role for Cl- and inhibitory transmitters. (1998) (58)
- Excitotoxicity in the embryonic chick spinal cord (1991) (55)
- Brain damage in mice from voluntary ingestion of glutamate and aspartate. (1980) (55)
- Glutamate and GABA receptor dysfunction in the fetal alcohol syndrome (2009) (54)
- Components of hypothalamic obesity: bipiperidyl-mustard lesions add hyperphagia to monosodium glutamate-induced hyperinsulinemia (1986) (52)
- Neuroprotectants in Honghua: glucose attenuates retinal ischemic damage. (1993) (51)
- Pathomorphologic effects of N‐methyl‐D‐aspartate antagonists in the rat posterior ingulate/retrosplenial cerebral cortex: A review (1994) (50)
- Role of excitotoxins in developmental neuropathology. (1993) (50)
- Intrastriatal folic acid mimics the distant but not local brain damaging properties of kainic acid (1981) (49)
- Drug-Induced Apoptosis: Mechanism by which Alcohol and Many Other Drugs can Disrupt Brain Development (2013) (49)
- Donepezil markedly potentiates memantine neurotoxicity in the adult rat brain (2008) (49)
- Comparison of behavioral effects of nucleus basalis magnocellularis lesions and somatosensory cortex ablation in the rat (1989) (48)
- Age-related changes in glutamate concentration and synaptosomal glutamate uptake in adult rat striatum. (1981) (48)
- α2 Adrenergic Agonists Prevent MK-801 Neurotoxicity (1995) (48)
- Glutamate antagonists: Deadly liaisons with cancer (2001) (48)
- Isoflurane and Propofol Block Neurotoxicity Caused by MK-801 in the Rat Posterior Cingulate/Retrosplenial Cortex (1997) (47)
- Letter: Neurotoxic effects of glutamate. (1973) (47)
- Acute behavioral effects of MK-801 in the mouse (1996) (46)
- Neurotoxicity of NMDA receptor antagonists: an overview. (1994) (46)
- Monosodium glutamate effects. (1971) (45)
- Effects of chronic morphine administration on the reproductive system of the male rat. (1975) (44)
- N-methylaspartate: an effective tool for lesioning basal forebrain cholinergic neurons of the rat (1986) (44)
- High Dose Magnesium Sulfate Exposure Induces Apoptotic Cell Death in the Developing Neonatal Mouse Brain (2009) (44)
- Luteinizing hormone releasing action ofN-methyl aspartate is blocked by GABA or taurine but not by dopamine antagonists (1978) (44)
- Excitatory neurotoxins as food additives: an evaluation of risk. (1981) (43)
- An ex vivo rat retinal preparation for excitotoxicity studies (1995) (42)
- Glumate receptor dysfunction and Alzheimer's disease. (1998) (42)
- Calcium-Stimulated Adenylyl Cyclases Modulate Ethanol-Induced Neurodegeneration in the Neonatal Brain (2005) (41)
- Fenamates protect neurons against ischemic and excitotoxic injury in chick embryo retina (1998) (40)
- Propofol and sodium thiopental protect against MK-801-induced neuronal necrosis in the posterior cingulate/retrosplenial cortex (2001) (40)
- Glutamate, a Neurotoxic Transmitter (1989) (40)
- Basal forebrain lesions impair tactile discrimination and working memory (1989) (40)
- Focus on Apoptosis to Decipher How Alcohol and Many Other Drugs Disrupt Brain Development (2014) (40)
- Excitotoxic neurodegeneration induced by deprivation of oxygen and glucose in isolated retina. (1998) (40)
- Involvement of glutamate in ischemic neurodegeneration in isolated retina (2003) (40)
- Ninety-six hour ketamine infusion with co-administered clonidine for treatment-resistant depression: A pilot randomised controlled trial (2016) (38)
- alpha-Aminoadipate blocks the neurotoxic action of N-methyl aspartate. (1979) (38)
- Spatiotemporal evolution of apoptotic neurodegeneration following traumatic injury to the developing rat brain (2006) (37)
- Further characterization of the extra-arcuate alpha-melanocyte stimulating hormone-like material in hypothalamus: Biochemical and anatomical studies (1986) (36)
- Lithium Protects Against Anaesthesia Neurotoxicity In The Infant Primate Brain (2016) (33)
- The Intact isolated (ex vivo) retina as a model system for the study of excitotoxicity (1998) (32)
- Excitatory amino acid neurotoxins: selectivity, specificity, and mechanisms of action. Based on an NRP one-day conference held June 30, 1980. (1981) (31)
- Excitotoxic Cell Death (1999) (31)
- Metabolic and pathological consequences of focal seizures. (1983) (27)
- Centripetal Sequence of Appearance of Receptor–Bipolar Synaptic Structures in Developing Mouse Retina (1968) (27)
- Antagonism of morphine analgesia by nonopioid cold-water swim analgesia: Direct evidence for collateral inhibition (1990) (27)
- Inhibition of cisplatin-induced emesis in ferrets by the non-NMDA receptor antagonists NBQX and CNQX (1992) (27)
- Swelling of Müller cells induced by AP3 and glutamate transport substrates in rat retina (1996) (26)
- Systemic dipiperidinoethane mimics the convulsant and neurotoxic actions of kainic acid (1980) (26)
- Behavioral Consequences of NMDA Antagonist-Induced Neuroapoptosis in the Infant Mouse Brain (2010) (26)
- Uptake of Exogenous Aspartate into Circumventricular Organs but Not Other Regions of Adult Mouse Brain (1984) (25)
- Excitotoxic food additives: functional teratological aspects. (1988) (25)
- Brain damage and associated behavioral deficits following the administration of L-cysteine to infant rats (1975) (24)
- Reversible action of N-methyl aspartate on gonadotrophin neuroregulation (1979) (24)
- Modeling pediatric head trauma: mechanisms of degeneration and potential strategies for neuroprotection. (1998) (23)
- Neuroendocrine interactions of excitatory and inhibitory amino acids (1980) (23)
- Increase in hypothalamic cholecystokinin following acute and chronic morphine (1986) (23)
- A highly toxic cellular prion protein induces a novel, nonapoptotic form of neuronal death. (2010) (23)
- Parallel Recovery of MK-801–Induced Spatial Learning Impairment and Neuronal Injury in Male Mice (1999) (22)
- Selective Alterations of Opiate Receptor Subtypes in Mono sodium Glutamate‐Treated Rats (1983) (21)
- Monosodium glutamate: specific brain lesion questioned. (1970) (20)
- Naloxone blocks morphine enhancement of kainic acid neurotoxicity. (1982) (20)
- Kainic acid and other excitotoxins: a comparative analysis. (1981) (20)
- Excitotoxic amino acids as neuroendocrine research tools. (1983) (20)
- Glutamatergic, Cholinergic, and GABAergic Systems in Posterior Cingulate Cortex: Interactions and Possible Mechanisms of Limbic System Disease (1993) (20)
- Characterization of Two Novel N-Methyl-D-aspartate Antagonists: EAA-090 (2-[8,9-Dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl]ethylphosphonic Acid) and EAB-318 (R-α-Amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoic Acid Hydrochloride) (2004) (20)
- Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats (2003) (19)
- Excitotoxicity and Neuropsychiatric Disorders (1991) (18)
- Developmental Neurotoxicity of Alcohol and Anesthetic Drugs Is Augmented by Co-Exposure to Caffeine (2013) (18)
- Blockade of the second messenger functions of the glutamate metabotropic receptor is associated with degenerative changes in the retina and brain of immature rodents (1995) (17)
- Comparison of rat retinal fixation techniques: chemical fixation and microwave irradiation. (2000) (17)
- Only certain anticonvulsants protect against kainate neurotoxicity. (1981) (17)
- Neonatal exposure to D,L-2-amino-3-phosphonopropionate (D,L-AP3) produces lesions in the eye and optic nerve of adult rats. (1993) (16)
- Dipiperidinoethane neurotoxicity clarified (1982) (15)
- Biochemical and morphological analysis of non-NMDA receptor mediated excitotoxicity in chick embryo retina (1999) (15)
- Minimal tissue concentrations of glutamate required to produce necrosis of hypothalamic neurons in newborn mice. (1979) (14)
- Adenylyl cyclases types 1 and 8 promote pro-survival pathways after ethanol exposure in the neonatal brain (2009) (14)
- Age dependent sensitivity of the rat retina to the excitotoxic action ofN-methyl-D-aspartate (1995) (14)
- Morphological and electrophysiological evidence for an ionotropic GABA receptor of novel pharmacology. (2002) (13)
- Creatine Phosphokinase and Psychiatric Illness (1974) (13)
- Mineralization of the globus pallidus following excitotoxic lesions of the basal forebrain (1995) (13)
- Discussion of Bogerts' temporolimbic system theory of paranoid schizophrenia. (1997) (11)
- Glutamate accumulation in infant mouse hypothalamus: influence of temperature. (1973) (11)
- Excitotoxic food additives--relevance of animal studies to human safety. (1984) (10)
- NMDA receptor hypofunction and schizophrenia (1995) (9)
- In Reply: Phencyclidine, Dizocilpine, and Cerebrocortical Neurons (1990) (9)
- alpha 2 adrenergic agonists prevent MK-801 neurotoxicity. (1995) (9)
- Glutamate-type hypothalamic-pituitary syndrome in mice treated with aspartate or cysteate in infancy (2005) (9)
- Chronic but not acute estradiol treatment protects against the neurodegenerative effects of N-methyl-d-aspartate receptor antagonists (2003) (9)
- Proliferation of lamellar whorls in arcuate neurons of the hypothalamus of castrated and morphine-treated male rats (1976) (8)
- Caffeine Augments Anesthesia Neurotoxicity in the Fetal Macaque Brain (2018) (8)
- Occult Mechanisms of Brain Dysfunction (1974) (8)
- NMDA receptor hypofunction, excitotoxicity, and Alzheimer's disease (1995) (8)
- Regional uptake of neurotoxic and nontoxic amino acids in vivo by the infant mouse brain. (1976) (8)
- TWO DICTIONARY TRANSCRIPTS AND PROGRAMS FOR PROCESSING THEM. VOLUME I. THE ENCODING SCHEME, PARSENT AND CONIX. (1969) (7)
- Role of ammonia in reversal of glutamate‐mediated Müller cell swelling in the rat retina (2004) (7)
- Increase in delta, but not mu, receptors in MSG-treated rats. (1982) (7)
- 76 NEUROPATHOLOGICAL CHANGES ASSOCIATED WITH INTRAVENOUS KAINIC ACID (1981) (6)
- Quisqualate Injection into the Nucleus Basalis Magnocellularis Produces Seizure-Related Brain Damage That Is Prevented by MK-801 (1994) (6)
- Brain and retinal damage from lathyrus excitotoxin, beta-N-oxalyl-L-alpha,beta-diaminopropionic acid. (1976) (5)
- Excitatory Transmitter Neurotoxicity and Alzheimer’s Disease (1994) (5)
- Excitatory Transmitters and Neuropsychiatry Disorders (1988) (5)
- Alcohol Damage to the Brain (2002) (5)
- Synthesis, phencyclidine-like pharmacology, and antiischemic potential of meta-substituted 1-(1-phenylcyclohexyl)-1,2,3,6-tetrahydropyridines. (1990) (4)
- Clozapine and related analogs back NMDA antagonist neurotoxicity: Implications for schizophrenia (1995) (4)
- NEUROTOXIC EFFECTS OF GLUTAMATE ON PRIMATE AREA POSTREMA (1978) (4)
- Mk 801 prevents thalamic damage induced by focal cortical seizures (1987) (4)
- Neuroendocrine effects of excitotoxic amino acids. (1981) (4)
- Hypothalamic neurotoxins alter the content of immunoreactive cholecystokinin in pituitary (1987) (4)
- Response to Commentaries and to the Challenge of Building a Perfect Theory to Explain Schizophrenia (1995) (4)
- Prolonged nitrous oxide anesthesia kills neurons in the adult rat brain. (1998) (4)
- Glutamatergic transmission: Therapeutic prospects for schizophrenia and Alzheimer’s disease (2001) (4)
- Is NMDA Receptor Hypofunction in Schizophrenia Associated With a Primary Hyperglutamatergic State (2002) (4)
- 123 ULTRASTRUCTURAL ANALYSIS OF HIPPOCAMPAL DAMAGE PRODUCED BY SUSTAINED PERFORANT PATH STIMULATION IN THE RAT (1981) (3)
- Proliferation of lamellar whorls in arcuate neurons of the hypothalamus of male rats treated with estradiol benzoate or cyproterone acetate (1977) (3)
- Domoic acid toxicity. Panel discussion: treatment. (1990) (2)
- NMDA Receptor Dysfunction in Alzheimer’s Disease (1997) (2)
- A2 adrenergic agonists prevent NMDA antagonist neurotoxicity (1995) (2)
- Pro: Anesthesia-induced Developmental Neuroapoptosis: Status of the Evidence (2009) (2)
- Dietary MSG and behavior. (1980) (2)
- Cholinergic Neurotoxicity: Mechanisms and Prevention (1986) (2)
- EXCITOTOXIC AMINO ACIDS AND HUNTINGTONʼS CHOREA: 87 (1977) (2)
- Relevance to Clinical Anesthesia of Anesthetic‐Induced Neurotoxicity in Developing Animals (2012) (1)
- Environmental Agents ThatHavethePotential toTrigger Massive Apoptotic Neurodegeneration intheDeveloping Brain (2000) (1)
- ALANOSINE - AN ANTILEUKEMIC AGENT WITH GLUTAMATE-LIKE NEUROTOXIC PROPERTIES: 88 (1977) (1)
- Developmental and molecular studies of mGluR5 (1996) (1)
- Acute and Chronic Neurodegenerative Disorders Produced by Dietary Excitotoxins (1992) (1)
- Computer processing of the etymologies in a standard dictionary - Preliminary results (1977) (1)
- Glutamate Receptor-Mediated Neurotoxicity (1995) (1)
- Neurocytotoxicity of phencyclidine and MK-801 (1989) (1)
- Comparison of the distribution of cholecystokinin and opioid peptides in rat hypothalamus (1985) (1)
- Excitotoxicity and Neurodegenerative Disorders (1992) (1)
- Status of monosodium glutamate revisited. (1973) (1)
- Response : Phencyclidine, Dizocilpine, and Cerebrocortical Neurons (1990) (0)
- an Ionotropic GABA Receptor of Novel Pharmacology Morphological and Electrophysiological Evidence for (2013) (0)
- Glutamate antagonists: Dead (2016) (0)
- N-Methyl-D-aspartate antagonists and apoptotic cell death triggered by head trauma in developing rat brain ( traumatic head injury y apoptosis y necrosis y excitotoxicity y neurodegeneration ) (1999) (0)
- Effect of Pyridostigmine and Cholino lytics on Cholinesterase and Acetylcholine in Soman-Poisoned Rats ' , Drug and Chemical Toxicology (2017) (0)
- Characterization of Two Novel N -Methyl- D -aspartate Antagonists: EAA-090 (2-[8,9-Dioxo-2,6-diazabicyclo Acid) and EAB-318 ( R - (cid:1) -Amino-5-chloro-1-(phosphonomethyl)-1 H -benzimidazole-2-propanoic Acid Hydrochloride) (2004) (0)
- Excitotoxic lbnino Acids (2002) (0)
- Letter from John W. Olney to Joshua Lederberg (1969) (0)
- Autoimmunization against cholecystokinin (CCK) potentiates morphine analgesia (1984) (0)
- Developmental expression of NMDA receptor subunits and NMDA-mediated toxicity in rat retina (1996) (0)
- Apolipoprotein-deficient mice are more susceptible to mild traumatic brain injury than are wild-type mice (2004) (0)
- Too Soft on FDA (1969) (0)
- 812 Nitrous Oxide Augments the Neurotoxic Side Effects of Ketamine in the Adult Rat Brain (1999) (0)
- Response : Carbamate Formation and the Neurotoxicity of L-α Amino Acids (1991) (0)
- BELL EXCITOTOXIC NEURONAL DAMAGE AND NEUROPSYCHIATRIC DISORDERS (2002) (0)
- Alcohol-induced apoptosis of oligodendrocytes in the fetal macaque brain (2013) (0)
- Subject Index Vol. 26, 1978 (1978) (0)
- EFFECTS OF AGE AND SEX ON NEUROTOXICITY CAUSED BY AN NMDA ANTAGONIST NITROUS OXIDE IN RAT CORTEX (1998) (0)
- Response (1990) (0)
- GABA inhibition of N-methyl-aspartate stimulated luteinizing hormone release (1979) (0)
- Chapter 18 – Excitotoxic neuronal damage and neuropsychiatric disorders (1996) (0)
- 366: Histologic Assessment of Free Radical Injury and Apoptotic Cell Death After Severe Traumatic Brain Injury (2006) (0)
- Contents, Vol. 26, 1978 (1978) (0)
- Response (1994) (0)
- 55 – Excitotoxic Amino Acids as Neuroendocrine Research Tools (1989) (0)
- Response : Monosodium Glutamate: Specific Brain Lesion Questioned (1970) (0)
- Caffeine Augments Anesthesia Neurotoxicity in the Fetal Macaque Brain (2018) (0)
- 1229 Morphological study on “apoptosis” in infant rat CNS (1997) (0)
- Synthesis of cysteine-35S-sulfate (1977) (0)
- Monosodium Glutamate Effects (1971) (0)
- Letter: Aspartame as a sweetener. (1975) (0)
- dtotoxid and the NMDA receptor (1987) (0)
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