What Schools Are Affiliated With John R. Falck

John R. Falck is affiliated with the following schools: University of Pittsburgh, Karolinska Institute, University of Texas Southwestern Medical Center, Harvard University, University of California, Berkeley, New York Medical College, University of Oxford, California Institute of Technology, University of Alberta, University of Strasbourg, University of Southern California, University of Iowa, University of Tennessee Health Science Center, Duke University, Colorado State University, Medical College of Wisconsin, Imperial College London, University College London, Vanderbilt University, Stanford University

John R. Falck | Academic Influence

John R. Falck's AcademicInfluence.com Rankings

John R. Falck

Chemistry

#1132

World Rank

#1789

Historical Rank

#454

USA Rank

chemistry Degrees

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Chemistry

John R. Falck's Degrees

Bachelors Chemistry University of California, Berkeley
PhD Chemistry Stanford University

Why Is John R. Falck Influential?

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According to Wikipedia, John Russell “Camille” Falck is an American chemist, Professor of Biochemistry, and holder of the Robert A. Welch Distinguish Chair in Chemistry at the University of Texas Southwestern Medical Center . In 1996 he was awarded the Wilfred T. Doherty Recognition Award from the Dallas-Forth Worth Section of the American Chemical Society and a Recognition Award at the March 10, 2002, Winter Eicosanoid Conference in appreciation of his significant contributions to the chemistry of natural products, and to the identification and functional characterization of the cytochrome P450 arachidonic acid monooxygenase metabolic pathway and its metabolites.

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John R. Falck's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

An oxysterol signalling pathway mediated by the nuclear receptor LXRα (1996) (1695)
Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. (1998) (858)
Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. (2000) (559)
Lysine Propionylation and Butyrylation Are Novel Post-translational Modifications in Histones*S (2007) (558)
Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3. (1994) (516)
The scavenger cell pathway for lipoprotein degradation: specificity of the binding site that mediates the uptake of negatively-charged LDL by macrophages. (1980) (492)
Molecular Cloning and Expression of CYP2J2, a Human Cytochrome P450 Arachidonic Acid Epoxygenase Highly Expressed in Heart (*) (1996) (476)
Targeting QseC Signaling and Virulence for Antibiotic Development (2008) (463)
High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity* (1997) (425)
Production of 20-HETE and its role in autoregulation of cerebral blood flow. (2000) (315)
Human cytochromes P450 (1999) (303)
A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. (2004) (301)
Cytochrome P450 and the arachidonate cascade 1 (1992) (294)
20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles. (1996) (293)
Endothelium-Derived Hyperpolarizing Factor in Human Internal Mammary Artery Is 11,12-Epoxyeicosatrienoic Acid and Causes Relaxation by Activating Smooth Muscle BKCa Channels (2003) (271)
20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries. (1993) (268)
Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1 (2003) (257)
Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle. (1992) (256)
Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. (2012) (253)
Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension (2001) (247)
Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles. (1996) (244)
Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells. (2001) (240)
Molecular Cloning, Expression, and Functional Significance of a Cytochrome P450 Highly Expressed in Rat Heart Myocytes* (1997) (237)
Cytochrome P450-derived arachidonic acid metabolism in the rat kidney: characterization of selective inhibitors. (1998) (236)
Visualization of acidic organelles in intact cells by electron microscopy. (1984) (233)
Amide-directed tandem C-C/C-N bond formation through C-H activation. (2012) (230)
Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells. (1998) (229)
Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels. (1994) (223)
Effect of cytochrome P450 arachidonate metabolites on ion transport in rabbit kidney loop of Henle. (1991) (220)
Regio- and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase. (1993) (219)
The CYP4A Isoforms Hydroxylate Epoxyeicosatrienoic Acids to Form High Affinity Peroxisome Proliferator-activated Receptor Ligands* (2002) (215)
Control of Intramolecular Interactions between the Pleckstrin Homology and Dbl Homology Domains of Vav and Sos1 Regulates Rac Binding* (2000) (209)
Arrestin function in G protein‐coupled receptor endocytosis requires phosphoinositide binding (1999) (206)
Actions of epoxygenase metabolites on the preglomerular vasculature. (1996) (203)
Inhibition of 20-HETE production contributes to the vascular responses to nitric oxide. (1997) (203)
Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism. (1988) (202)
14,15-Epoxyeicosa-5(Z)-enoic Acid: A Selective Epoxyeicosatrienoic Acid Antagonist That Inhibits Endothelium-Dependent Hyperpolarization and Relaxation in Coronary Arteries (2002) (202)
Direct Stereospecific Synthesis of Unprotected N-H and N-Me Aziridines from Olefins (2014) (200)
Arachidonic acid metabolites as endothelium-derived hyperpolarizing factors. (2007) (198)
Stereospecific effects of epoxyeicosatrienoic acids on renal vascular tone and K(+)-channel activity. (1996) (198)
Role of Soluble Epoxide Hydrolase in Postischemic Recovery of Heart Contractile Function (2006) (197)
Soluble Epoxide Hydrolase: A Novel Therapeutic Target in Stroke (2007) (196)
Formation of 19(S)-, 19(R)-, and 18(R)-hydroxyeicosatetraenoic acids by alcohol-inducible cytochrome P450 2E1. (1993) (191)
Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet. (1994) (190)
Characterization of the mitochondrial carnitine palmitoyltransferase enzyme system. I. Use of inhibitors. (1987) (181)
A Functional Phosphatidylinositol 3,4,5-Trisphosphate/Phosphoinositide Binding Domain in the Clathrin Adaptor AP-2 α Subunit. IMPLICATIONS FOR THE ENDOCYTIC PATHWAY* (1996) (177)
Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis (2005) (177)
The reaction of arachidonic acid epoxides (epoxyeicosatrienoic acids) with a cytosolic epoxide hydrolase. (1983) (176)
Intestinal vasodilation by epoxyeicosatrienoic acids: arachidonic acid metabolites produced by a cytochrome P450 monooxygenase. (1987) (173)
Nitric oxide-20-hydroxyeicosatetraenoic acid interaction in the regulation of K+ channel activity and vascular tone in renal arterioles. (1998) (173)
An Active Site Substitution, F87V, Converts Cytochrome P450 BM-3 into a Regio- and Stereoselective (14S,15R)-Arachidonic Acid Epoxygenase* (1997) (170)
Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition. (2006) (169)
Epoxyeicosatrienoic Acids Regulate Trp Channel–Dependent Ca2+ Signaling and Hyperpolarization in Endothelial Cells (2007) (169)
DIRECT PREPARATION OF 2-DEOXY-D-GLUCOPYRANOSIDES FROM GLUCALS WITHOUT FERRIER REARRANGEMENT (1990) (168)
Metabolism of 20-hydroxyeicosatetraenoic acid by cyclooxygenase. Formation and identification of novel endothelium-dependent vasoconstrictor metabolites. (1989) (168)
Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform. (1995) (165)
Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets. (1983) (164)
Characterization of 5,6- and 8,9-Epoxyeicosatrienoic Acids (5,6- and 8,9-EET) as Potent in Vivo Angiogenic Lipids* (2005) (164)
20-Hydroxyeicosatetraenoic Acid Stimulates Nuclear Factor-κB Activation and the Production of Inflammatory Cytokines in Human Endothelial Cells (2008) (163)
Dirhodium-catalyzed C-H arene amination using hydroxylamines (2016) (163)
Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia. (2008) (162)
The Highly Stereoselective Oxidation of Polyunsaturated Fatty Acids by Cytochrome P450BM-3* (1996) (160)
Requirement of Inositol Pyrophosphates for Full Exocytotic Capacity in Pancreatic β Cells (2007) (156)
EDHF mediates flow-induced dilation in skeletal muscle arterioles of female eNOS-KO mice. (2001) (154)
Global identification of O-GlcNAc-modified proteins. (2006) (153)
Endogenous epoxyeicosatrienoyl-phospholipids. A novel class of cellular glycerolipids containing epoxidized arachidonate moieties. (1991) (151)
20-hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling. (2008) (148)
Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension‐induced renal injury in mice (2010) (143)
Cytochrome P450 Eicosanoids are Activators of Peroxisome Proliferator-Activated Receptor α (2007) (143)
Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. (2006) (142)
The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility through Protein Kinase C* (1997) (141)
Epoxyeicosatrienoic Acids and Their Sulfonimide Derivatives Stimulate Tyrosine Phosphorylation and Induce Mitogenesis in Renal Epithelial Cells* (1998) (140)
Epoxyeicosatrienoic Acid Agonist Rescues the Metabolic Syndrome Phenotype of HO-2-Null Mice (2009) (139)
Selective epoxidation of eicosa-cis-5,8,11,14-tetraenoic (arachidonic) acid and eicosa-cis-8,11,14-trienoic acid (1979) (138)
Cytochrome P450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system (1996) (138)
Effect of P-450 omega-hydroxylase metabolites of arachidonic acid on tubuloglomerular feedback. (1994) (136)
Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats. (2008) (136)
The general anesthetic propofol increases brain N‐arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase (2003) (136)
Ca2+/Calmodulin Reverses Phosphatidylinositol 3,4,5-Trisphosphate-dependent Inhibition of Regulators of G Protein-signaling GTPase-activating Protein Activity* (2000) (136)
Cytochrome P-450 arachidonic acid epoxygenase. Regulatory control of the renal epoxygenase by dietary salt loading. (1992) (135)
Identification of palmitoylated mitochondrial proteins using a bio‐orthogonal azido‐palmitate analogue (2008) (135)
Calcium Influx Factor, Further Evidence It Is 5,6-Epoxyeicosatrienoic Acid* (1999) (135)
Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice (2011) (134)
Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase. (1990) (134)
Mild and rapid hydroxylation of aryl/heteroaryl boronic acids and boronate esters with N-oxides. (2012) (134)
20-HETE agonists and antagonists in the renal circulation. (1999) (133)
Binding of Two Flaviolin Substrate Molecules, Oxidative Coupling, and Crystal Structure of Streptomyces coelicolor A3(2) Cytochrome P450 158A2* (2005) (132)
Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. (1982) (132)
Urinary 20-Hydroxyeicosatetraenoic Acid Is Associated With Endothelial Dysfunction in Humans (2004) (132)
Vasoactivity of 20-hydroxyeicosatetraenoic acid is dependent on metabolism by cyclooxygenase. (1989) (131)
Cytochrome P-450-dependent HETEs: profile of biological activity and stimulation by vasoactive peptides. (1996) (130)
The CYP P450 arachidonic acid monooxygenases: from cell signaling to blood pressure regulation. (2001) (129)
Tagging-via-substrate strategy for probing O-GlcNAc modified proteins. (2005) (129)
Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450. (1986) (128)
Role of tyrosine kinase and PKC in the vasoconstrictor response to 20-HETE in renal arterioles. (1999) (128)
Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors. (2002) (127)
Rhodium-catalyzed annulation of N-benzoylsulfonamide with isocyanide through C-H activation. (2011) (127)
Epoxyeicosanoids promote organ and tissue regeneration (2013) (126)
Kinetic profile of the rat CYP4A isoforms: arachidonic acid metabolism and isoform-specific inhibitors. (1999) (125)
Total Synthesis of Erythromycins. 4. Total Synthesis of Erythronolide B1 (1978) (125)
Epoxygenase Metabolites Contribute to Nitric Oxide-Independent Afferent Arteriolar Vasodilation in Response to Bradykinin (2001) (125)
Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis. (1995) (124)
Carbon monoxide signaling in promoting angiogenesis in human microvessel endothelial cells. (2005) (124)
Liquid chromatographic-electrospray ionization-mass spectrometric analysis of cytochrome P450 metabolites of arachidonic acid. (2001) (123)
Epoxyeicosatrienoic Acids Are Released to Mediate Shear Stress–Dependent Hyperpolarization of Arteriolar Smooth Muscle (2005) (122)
Efficient iridium-catalyzed C-H functionalization/silylation of heteroarenes. (2008) (122)
Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension. (2007) (122)
Vasoactivity of arachidonic acid epoxides. (1987) (122)
N-acylsulfonamide assisted tandem C-H olefination/annulation: synthesis of isoindolinones. (2011) (122)
Human platelets and polymorphonuclear leukocytes synthesize oxygenated derivatives of arachidonylethanolamide (anandamide): their affinities for cannabinoid receptors and pathways of inactivation. (1998) (120)
The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s). (1995) (120)
Inhibition of Cytochrome P450&ohgr;-Hydroxylase: A Novel Endogenous Cardioprotective Pathway (2004) (120)
Enantioselective, Organocatalytic Oxy-Michael Addition to γ/δ-Hydroxy-α,β-enones: Boronate-Amine Complexes as Chiral Hydroxide Synthons (2008) (120)
Novel conversion of epoxides to one carbon homologated allylic alcohols by dimethylsulfonium methylide (1994) (119)
Transfection of an Active Cytochrome P450 Arachidonic Acid Epoxygenase Indicates That 14,15-Epoxyeicosatrienoic Acid Functions as an Intracellular Second Messenger in Response to Epidermal Growth Factor* (1999) (119)
Synthesis of lipoxygenase and epoxygenase products of arachidonic acid by normal and stenosed canine coronary arteries. (1990) (118)
Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response (2008) (118)
The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity Published, JLR Papers in Press, December 1, 2004. DOI 10.1194/jlr.M400377-JLR200 (2005) (118)
Structural Analysis and Detection of Biological Inositol Pyrophosphates Reveal That the Family of VIP/Diphosphoinositol Pentakisphosphate Kinases Are 1/3-Kinases* (2009) (116)
Cytochrome P450 and arachidonic acid metabolites: role in myocardial ischemia/reperfusion injury revisited. (2005) (115)
Tin-Copper Transmetalation: Cross-Coupling of .alpha.-Heteroatom-Substituted Alkyltributylstannanes with Organohalides (1995) (115)
Biochemical and molecular properties of the cytochrome P450 arachidonic acid monooxygenases. (2002) (115)
Cyclooxygenase dependency of the renovascular actions of cytochrome P450-derived arachidonate metabolites. (1992) (115)
Total synthesis of erythromycins. 5. Total synthesis of erythronolide A [41] (1979) (114)
Cytochrome P450 Epoxygenase Gene Function in Hypoxic Pulmonary Vasoconstriction and Pulmonary Vascular Remodeling (2006) (113)
Epoxyeicosatrienoic acids are part of the VEGF-activated signaling cascade leading to angiogenesis. (2008) (113)
Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism (2009) (112)
Cytochrome P450-derived renal HETEs: storage and release. (1997) (111)
The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: characterization and significance. (1995) (111)
Activation of Vascular Endothelial Growth Factor through Reactive Oxygen Species Mediates 20-Hydroxyeicosatetraenoic Acid-Induced Endothelial Cell Proliferation (2007) (111)
Renal vasodilator activity of 5,6-epoxyeicosatrienoic acid depends upon conversion by cyclooxygenase and release of prostaglandins. (1993) (110)
Purification, Sequencing, and Molecular Identification of a Mammalian PP-InsP5 Kinase That Is Activated When Cells Are Exposed to Hyperosmotic Stress* (2007) (110)
Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts. (2007) (108)
Rhodium catalyzed C-H olefination of N-benzoylsulfonamides with internal alkenes. (2012) (108)
Action of luteinizing hormone-releasing hormone: involvement of novel arachidonic acid metabolites. (1983) (108)
Elusive metal-free primary amination of arylboronic acids: synthetic studies and mechanism by density functional theory. (2012) (108)
Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs. (2001) (107)
Rapid detection, discovery, and identification of post‐translationally myristoylated proteins during apoptosis using a bio‐orthogonal azidomyristate analog (2008) (107)
14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-alpha. (2006) (106)
Arachidonic Acid Inhibits Epithelial Na Channel Via Cytochrome P450 (CYP) Epoxygenase-dependent Metabolic Pathways (2004) (106)
Epoxyeicosatrienoic acid agonist regulates human mesenchymal stem cell-derived adipocytes through activation of HO-1-pAKT signaling and a decrease in PPARγ. (2010) (105)
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. (2011) (104)
Hydrogen Peroxide Inhibits Cytochrome P450 Epoxygenases: Interaction Between Two Endothelium-Derived Hyperpolarizing Factors (2008) (104)
Elevated renovascular tone in young spontaneously hypertensive rats. Role of cytochrome P-450. (1993) (104)
Arachidonic acid epoxygenase: structural characterization and quantification of epoxyeicosatrienoates in plasma. (1992) (102)
Peroxisomal Proliferator-activated Receptor-α-dependent Inhibition of Endothelial Cell Proliferation and Tumorigenesis* (2007) (102)
Afferent arteriolar vasodilation to the sulfonimide analog of 11, 12-epoxyeicosatrienoic acid involves protein kinase A. (1999) (100)
Bradykinin‐induced, endothelium‐dependent responses in porcine coronary arteries: involvement of potassium channel activation and epoxyeicosatrienoic acids (2005) (100)
Regulation of AP-3 Function by Inositides (1997) (99)
The Diadenosine Hexaphosphate Hydrolases fromSchizosaccharomyces pombe andSaccharomyces cerevisiae Are Homologues of the Human Diphosphoinositol Polyphosphate Phosphohydrolase (1999) (97)
Stereospecific palladium/copper cocatalyzed cross-coupling of .alpha.-alkoxy- and .alpha.-aminostannanes with acyl chlorides (1994) (96)
Contribution of 20-HETE to the vasodilator actions of nitric oxide in renal arteries. (1998) (96)
QseC Inhibitors as an Antivirulence Approach for Gram-Negative Pathogens (2014) (95)
Role of EDHF in type 2 diabetes-induced endothelial dysfunction. (2008) (94)
CYP3A4 Mediates Growth of Estrogen Receptor-positive Breast Cancer Cells in Part by Inducing Nuclear Translocation of Phospho-Stat3 through Biosynthesis of (±)-14,15-Epoxyeicosatrienoic Acid (EET)* (2011) (94)
Contribution of cytochrome P450 epoxygenase and hydroxylase pathways to afferent arteriolar autoregulatory responsiveness (1999) (94)
PGC-1 alpha regulates HO-1 expression, mitochondrial dynamics and biogenesis: Role of epoxyeicosatrienoic acid. (2016) (94)
Identification of the 11,14,15- and 11,12,15-Trihydroxyeicosatrienoic Acids as Endothelium-derived Relaxing Factors of Rabbit Aorta* (1998) (93)
20-Hydroxy-5,8,11,14-eicosatetraenoic Acid Mediates Endothelial Dysfunction via IκB Kinase-Dependent Endothelial Nitric-Oxide Synthase Uncoupling (2010) (93)
Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase. (1993) (93)
Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart. (2008) (92)
Stereospecific Suzuki cross-coupling of alkyl alpha-cyanohydrin triflates. (2010) (92)
Mechanism and signal transduction of 14 (R), 15 (S)-epoxyeicosatrienoic acid (14,15-EET) binding in guinea pig monocytes. (2000) (92)
Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1–dependent microvascular degeneration (2005) (92)
P-450 epoxygenase and NO synthase inhibitors reduce cerebral blood flow response to N-methyl-D-aspartate. (2000) (92)
Parathyroid hormone inhibits Na(+)-K(+)-ATPase through a cytochrome P-450 pathway. (1994) (91)
Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta. (1991) (91)
Effects of 20-HETE and 19(S)-HETE on rabbit proximal straight tubule volume transport. (2000) (91)
Rapid and selective detection of fatty acylated proteins using ω-alkynyl-fatty acids and click chemistry[S] (2010) (91)
2-Arachidonoylglycerol (2004) (90)
Role of cGMP versus 20-HETE in the vasodilator response to nitric oxide in rat cerebral arteries. (2000) (90)
Characterization of Epoxyeicosatrienoic Acid Binding Site in U937 Membranes Using a Novel Radiolabeled Agonist, 20-125I-14,15-Epoxyeicosa-8(Z)-Enoic Acid (2008) (89)
Inhibitors of cytochrome P450 4A suppress angiogenic responses. (2005) (89)
Interaction of Mechanisms Involving Epoxyeicosatrienoic Acids, Adenosine Receptors, and Metabotropic Glutamate Receptors in Neurovascular Coupling in Rat Whisker Barrel Cortex (2008) (89)
Role of SKCa and IKCa in endothelium‐dependent hyperpolarizations of the guinea‐pig isolated carotid artery (2005) (89)
Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury. (2006) (89)
Antinociception Produced by 14,15-Epoxyeicosatrienoic Acid Is Mediated by the Activation of β-Endorphin and Met-Enkephalin in the Rat Ventrolateral Periaqueductal Gray (2008) (89)
Selective delivery of cytotoxic compounds to cells by the LDL pathway. (1984) (88)
Gender-specific compensation for the lack of NO in the mediation of flow-induced arteriolar dilation. (2001) (88)
Total synthesis of erythromycins. 3. Stereoselective routes to intermediates corresponding to C(1) to C(9) and C(10) to C(13) fragments of erythronolide B (1978) (88)
Cytochrome P-450 arachidonate metabolites in rat kidney: characterization and hemodynamic responses. (1990) (88)
Phospholipase A2-mediated activation of mitogen-activated protein kinase by angiotensin II. (1998) (87)
Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries. (2000) (87)
20-HETE Signals Through G-Protein–Coupled Receptor GPR75 (Gq) to Affect Vascular Function and Trigger Hypertension (2017) (87)
Endothelial nitric oxide synthase activation leads to dilatory H2O2 production in mouse cerebral arteries. (2007) (86)
Cytochrome P450 CYP2J9, a New Mouse Arachidonic Acid ω-1 Hydroxylase Predominantly Expressed in Brain* (2001) (86)
Cytochrome P-450 arachidonate oxygenase. (1990) (86)
Comparison of vasodilatory properties of 14,15-EET analogs: structural requirements for dilation. (2003) (86)
Epoxyeicosatrienoic acids limit damage to mitochondrial function following stress in cardiac cells. (2009) (85)
Ag(I)-promoted Suzuki–Miyaura cross-couplings of n-alkylboronic acids (2001) (85)
Increasing or stabilizing renal epoxyeicosatrienoic acid production attenuates abnormal renal function and hypertension in obese rats. (2007) (85)
12(R)-hydroxyeicosatrienoic acid: a vasodilator cytochrome P-450-dependent arachidonate metabolite from the bovine corneal epithelium. (1988) (85)
Cytochrome P-450-dependent oxidation of arachidonic acid to 16-, 17-, and 18-hydroxyeicosatetraenoic acids. (1990) (85)
Cytochrome P450 and cyclooxygenase metabolites contribute to the endothelin-1 afferent arteriolar vasoconstrictor and calcium responses. (2000) (85)
Post-receptor signal transduction and regulation of 14(R),15(S)-epoxyeicosatrienoic acid (14,15-EET) binding in U-937 cells. (1997) (84)
Effect of angiotensin II on the apical K+ channel in the thick ascending limb of the rat kidney (1996) (83)
20-Hydroxyeicosatetraenoic acid is formed in response to EGF and is a mitogen in rat proximal tubule. (1995) (83)
Controlled chemical synthesis of the enzymatically produced eicosanoids 11-, 12-, and 15-HETE from arachidonic acid and conversion into the corresponding hydroperoxides(HPETE) [13] (1980) (83)
Endogenous epoxyeicosatrienoic acids. Cytochrome P-450 controlled stereoselectivity of the hepatic arachidonic acid epoxygenase. (1989) (83)
14,15-Epoxyeicosatrienoic Acid Represents a Transferable Endothelium-Dependent Relaxing Factor in Bovine Coronary Arteries (2005) (82)
Cytochrome P-450 arachidonate metabolites affect ion fluxes in rabbit medullary thick ascending limb. (1994) (81)
Brain Synthesis and Cerebrovascular Action of Epoxygenase Metabolites of Arachidonic Acid (1992) (81)
Functional Coupling of Phosphatidylinositol 4,5-Bisphosphate to Inositol 1,4,5-Trisphosphate Receptor* (1998) (81)
Crosstalk between EET and HO-1 downregulates Bach1 and adipogenic marker expression in mesenchymal stem cell derived adipocytes. (2011) (81)
Carbon monoxide and biliverdin prevent endothelial cell sloughing in rats with type I diabetes. (2006) (81)
Products of heme-catalyzed transformation of the arachidonate derivative 12-HPETE open S-type K+ channels in Aplysia (1989) (80)
20-HETE and F2-isoprostanes in the metabolic syndrome: the effect of weight reduction. (2009) (80)
Stimulation of rat erythrocyte P2X7 receptor induces the release of epoxyeicosatrienoic acids (2006) (80)
Protective effect of 20-HETE analogues in experimental renal ischemia reperfusion injury. (2009) (79)
Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells. (1997) (79)
Catalytic Activity and Isoform-Specific Inhibition of Rat Cytochrome P450 4F Enzymes (2004) (79)
Adenosine2A receptor vasodilation of rat preglomerular microvessels is mediated by EETs that activate the cAMP/PKA pathway. (2006) (78)
Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex. (2008) (78)
Epoxyeicosatrienoic acid prevents postischemic electrocardiogram abnormalities in an isolated heart model. (2009) (78)
Cytochrome P4502C9-Derived Epoxyeicosatrienoic Acids Induce the Expression of Cyclooxygenase-2 in Endothelial Cells (2004) (77)
Inhibition of 20-HETE synthesis and action protects the kidney from ischemia/reperfusion injury. (2011) (77)
Identification of Novel Endogenous Cytochrome P450 Arachidonate Metabolites with High Affinity for Cannabinoid Receptors* (2008) (77)
Novel orally active epoxyeicosatrienoic acid (EET) analogs attenuate cisplatin nephrotoxicity (2013) (77)
14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition. (2009) (76)
Effects of a 20-HETE antagonist and agonists on cerebral vascular tone. (2004) (76)
Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries. (2005) (75)
19(S)-hydroxyeicosatetraenoic acid is a potent stimulator of renal Na+-K+-ATPase. (1988) (74)
Platelet-neutrophil interactions. (12S)-hydroxyeicosatetraen-1,20-dioic acid: a new eicosanoid synthesized by unstimulated neutrophils from (12S)-20-dihydroxyeicosatetraenoic acid. (1988) (72)
The vasodilator 17,18‐epoxyeicosatetraenoic acid targets the pore‐forming BK α channel subunit in rodents (2007) (72)
CYP4A2-Induced Hypertension Is 20-Hydroxyeicosatetraenoic Acid- and Angiotensin II-Dependent (2010) (72)
11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression. (2003) (71)
5,6-EET inhibits ion transport in collecting duct by stimulating endogenous prostaglandin synthesis. (1995) (71)
Cytochrome P450 ω-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer (2011) (71)
Cytochrome P450 arachidonic acid epoxygenase: stereochemical characterization of epoxyeicosatrienoic acids. (1991) (71)
Phosphorylation of the Platelet p47 Phosphoprotein Is Mediated by the Lipid Products of Phosphoinositide 3-Kinase (*) (1995) (70)
Recent studies on the chemical synthesis of eicosanoids. (1980) (70)
Novel glutathione conjugates formed from epoxyeicosatrienoic acids (EETs). (1985) (69)
14,15-EET analogs: characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries. (2004) (69)
20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells. (2008) (69)
Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer. (2013) (69)
Afferent Arteriolar Dilation to 11, 12‐EET Analogs Involves PP2A Activity and Ca2+‐Activated K+ Channels (2008) (68)
Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney. (1991) (67)
Functional characterization of cytochrome P450-derived epoxyeicosatrienoic acids in adipogenesis and obesity (2014) (66)
Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid (2001) (66)
Cytochrome P450 omega-hydroxylase inhibition reduces infarct size during reperfusion via the sarcolemmal KATP channel. (2004) (66)
20-hydroxyeicosatetraenoic acid is an endothelium-dependent vasoconstrictor in rabbit arteries. (1993) (65)
Arachidonic acid epoxygenase (1990) (65)
14,15-Dihydroxyeicosatrienoic acid relaxes bovine coronary arteries by activation of K(Ca) channels. (2002) (65)
EET agonist prevents adiposity and vascular dysfunction in rats fed a high fat diet via a decrease in Bach 1 and an increase in HO-1 levels. (2012) (65)
Removal of sulfur groups from molecules by copper(I). Preparation of sulfur-substituted 1,3-dienes for the Diels-Alder reaction (1976) (64)
Novel mechanism of brain soluble epoxide hydrolase‐mediated blood pressure regulation in the spontaneously hypertensive rat (2005) (64)
Hypoxic pulmonary vasoconstriction is modified by P-450 metabolites. (2000) (64)
Cardioprotective effect of a dual acting epoxyeicosatrienoic acid analogue towards ischaemia reperfusion injury (2011) (63)
Targeted killing of cultured cells by receptor-dependent photosensitization. (1981) (63)
Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer. (2012) (63)
Evidence for a membrane site of action for 14,15-EET on expression of aromatase in vascular smooth muscle. (2002) (63)
Microsomal cytochrome P450 and eicosanoid metabolism (2002) (63)
Synthesis of arachidonic acid metabolites produced by purified kidney cortex microsomal cytochrome P-450 (1983) (63)
Further Evidence Implicating a Cytochrome P‐450‐Mediated Reaction in the Contractile Tension of the Lamb Ductus Arteriosus (1988) (62)
Contribution of cytochrome P-450 omega-hydroxylase to altered arteriolar reactivity with high-salt diet and hypertension. (2000) (62)
Asymmetric total synthesis of (+)-fostriecin. (2002) (62)
Arachidonic acid epoxidation: epoxyeicosatrienoic acids are endogenous constituents of rat liver. (1984) (61)
EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides[S] (2012) (61)
A Role for Heterocellular Coupling and EETs in Dilation of Rat Cremaster Arteries (2006) (61)
Cytochrome P450 metabolites of arachidonic acid are potent inhibitors of vasopressin action on rabbit cortical collecting duct. (1989) (61)
Estrogen Elicits Cytochrome P450—Mediated Flow-Induced Dilation of Arterioles in NO Deficiency: Role of PI3K-Akt Phosphorylation in Genomic Regulation (2004) (61)
Application of copper(I)-induced thiophenoxide removal to ring expansions or chain extensions of aldehydes and ketones. Detection, Isolation, and independent preparation of the .alpha.-epoxy thioether intermediate (1975) (61)
Transition-Metal-Free ipso-Functionalization of Arylboronic Acids and Derivatives. (2014) (61)
Induction of Angiotensin-Converting Enzyme and Activation of the Renin–Angiotensin System Contribute to 20-Hydroxyeicosatetraenoic Acid–Mediated Endothelial Dysfunction (2012) (61)
Epoxyeicosatrienoic acids mediate adenosine‐induced vasodilation in rat preglomerular microvessels (PGMV) via A2A receptors (2004) (60)
Contributions of nitric oxide, EDHF, and EETs to endothelium-dependent relaxation in renal afferent arterioles. (2003) (60)
Abdominal Surgical Incision Induces Remote Preconditioning of Trauma (RPCT) via Activation of Bradykinin Receptors (BK2R) and the Cytochrome P450 Epoxygenase Pathway in Canine Hearts (2011) (60)
20-Hydroxyeicosatetraenoic acid is excreted as a glucuronide conjugate in human urine. (1992) (59)
Epoxyeicosatrienoic acid analogue lowers blood pressure through vasodilation and sodium channel inhibition. (2014) (59)
Epoxyeicosatrienoic acids pretreatment improves amyloid β-induced mitochondrial dysfunction in cultured rat hippocampal astrocytes. (2014) (59)
Synthesis of epoxyeicosatrienoic acids and heteroatom analogs. (1990) (59)
14(R),15(S)-epoxyeicosatrienoic acid (14(R),15(S)-EET) receptor in guinea pig mononuclear cell membranes. (1993) (59)
Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE. (2009) (58)
Phosphatidylinositol(3, 4, 5) -Trisphosphate Stimulates Phosphorylation of Pleckstrin in Human Platelets (*) (1995) (58)
17(R),18(S)-epoxyeicosatetraenoic acid, a potent eicosapentaenoic acid (EPA) derived regulator of cardiomyocyte contraction: structure-activity relationships and stable analogues. (2011) (58)
Enhancement of Cardiac L-Type Ca2+ Currents in Transgenic Mice with Cardiac-Specific Overexpression of CYP2J2 (2004) (58)
Smooth Muscle—Specific Expression of CYP4A1 Induces Endothelial Sprouting in Renal Arterial Microvessels (2004) (58)
Epoxygenase products of arachidonic acid are endogenous constituents of the hypothalamus involved in D2 receptor-mediated, dopamine-induced release of somatostatin. (1990) (58)
Involvement of eicosanoids in release of oxytocin and vasopressin from the neural lobe of the rat pituitary. (1985) (56)
2-Arachidonoylglycerol: A Novel Inhibitor of Androgen-Independent Prostate Cancer Cell Invasion (2004) (56)
Mechanism of ATP-Induced Local and Conducted Vasomotor Responses in Isolated Rat Cerebral Penetrating Arterioles (2008) (56)
Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase. (2013) (56)
9L Gliosarcoma Cell Proliferation and Tumor Growth in Rats Are Suppressed by N-Hydroxy-N′-(4-butyl-2-methylphenol) Formamidine (HET0016), a Selective Inhibitor of CYP4A (2006) (56)
Orally Active Epoxyeicosatrienoic Acid Analog Attenuates Kidney Injury in Hypertensive Dahl Salt–Sensitive Rat (2013) (56)
The Cyp2c44 Epoxygenase Regulates Epithelial Sodium Channel Activity and the Blood Pressure Responses to Increased Dietary Salt* (2013) (55)
Modulation by 20-HETE of Phenylephrine-Induced Mesenteric Artery Contraction in Spontaneously Hypertensive and Wistar-Kyoto Rats (2001) (55)
Cyclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes (2013) (55)
Integration of hypoxic dilation signaling pathways for skeletal muscle resistance arteries. (2002) (55)
Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells. (2006) (54)
20-Hydroxyeicosatetraenoic Acid (20-HETE) Metabolism in Coronary Endothelial Cells* (2004) (54)
A method for the determination of 5,6-EET using the lactone as an intermediate in the formation of the diol. (1998) (54)
Cytochrome P450 metabolites of arachidonic acid may be important mediators in angiotensin II-induced vasoconstriction in the rat mesentery in vivo. (2000) (54)
Regulation of Vascular Tone During Pregnancy: A Novel Role for the Pregnane X Receptor (2007) (54)
Epoxyeicosatrienoic acids protect cardiac cells during starvation by modulating an autophagic response (2013) (54)
EET intervention on Wnt1, NOV, and HO-1 signaling prevents obesity-induced cardiomyopathy in obese mice. (2017) (54)
5,6-Epoxyeicosatrienoic acid mobilizes Ca2+ in anterior pituitary cells. (1986) (53)
20-HETE Regulates the Angiogenic Functions of Human Endothelial Progenitor Cells and Contributes to Angiogenesis In Vivo (2014) (53)
Role of phospholipase C and diacylglyceride lipase pathway in arachidonic acid release and acetylcholine-induced vascular relaxation in rabbit aorta. (2006) (53)
Effects of newly reported arachidonic acid metabolites on microsomal Ca++ binding, uptake and release. (1983) (53)
Role of epoxyeicosatrienoic acids as autocrine metabolites in glutamate-mediated K+ signaling in perivascular astrocytes. (2010) (53)
(Z)-alpha-haloacrylates: an exceptionally stereoselective preparation via Cr(II)-mediated olefination of aldehydes with trihaloacetates. (2003) (53)
CYP2J2 Overexpression Protects against Arrhythmia Susceptibility in Cardiac Hypertrophy (2013) (52)
14,15-Epoxyeicosa-5(Z)-Enoic-mSI: A 14,15- and 5,6-EET Antagonist in Bovine Coronary Arteries (2003) (52)
Development of Epoxyeicosatrienoic Acid Analogs with in Vivo Anti-Hypertensive Actions (2010) (52)
Identification of 5,6-trans-Epoxyeicosatrienoic Acid in the Phospholipids of Red Blood Cells* (2004) (52)
Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxation. (2007) (52)
20-Hydroxyeicosatetraenoic Acid Contributes to the Inhibition of K+ Channel Activity and Vasoconstrictor Response to Angiotensin II in Rat Renal Microvessels (2013) (52)
5,6-epoxyeicosatrienoic acid, a novel arachidonate metabolite. Mechanism of vasoactivity in the rat. (1990) (52)
Diphospho-myo-inositol phosphates from Dictyostelium identified as D-6-diphospho-myo-inositol pentakisphosphate and D-5,6-bisdiphospho-myo-inositol tetrakisphosphate. (1997) (52)
Role of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factor in bovine coronary arteries. (2001) (52)
Intracellular Mediators: Synthesis of L-.alpha.-Phosphatidyl-D-myo-inositol 3,4,5-Trisphosphate and Glyceryl Ether Analogs (1995) (52)
Diverse roles of 2‐arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12‐lipoxygenase metabolism (2007) (52)
Characterization of 14,15-Epoxyeicosatrienoyl-Sulfonamides as 14,15-Epoxyeicosatrienoic Acid Agonists: Use for Studies of Metabolism and Ligand Binding (2007) (52)
20-Iodo-14,15-epoxyeicosa-8(Z)-enoyl-3-azidophenylsulfonamide: photoaffinity labeling of a 14,15-epoxyeicosatrienoic acid receptor. (2011) (52)
The Biological Actions of 11,12-Epoxyeicosatrienoic Acid in Endothelial Cells Are Specific to the R/S-Enantiomer and Require the Gs Protein (2014) (51)
Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock. (2013) (51)
The mechanism of oleic acid nitration by *NO(2). (2008) (51)
Synthesis of curacin A, an antimitotic cyclopropane-thiazoline from the marine cyanobacterium Lyngbya majuscula (1996) (51)
Synthesis of dihomoprostaglandins from adrenic acid (7,10,13,16-docosatetraenoic acid) by human endothelial cells. (1985) (50)
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism. (2009) (50)
Arachidonic acid epoxygenase: detection of epoxyeicosatrienoic acids in human urine. (1987) (50)
Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats. (2010) (50)
Arachidonate epoxygenase: identification of epoxyeicosatrienoic acids in rabbit kidney. (1987) (50)
Measurement of 20-hydroxyeicosatetraenoic acid in human urine by gas chromatography-mass spectrometry. (2004) (49)
Human U251 Glioma Cell Proliferation Is Suppressed by HET0016 [N-Hydroxy-N′-(4-butyl-2-methylphenyl)formamidine], a Selective Inhibitor of CYP4A (2005) (49)
PPARα activation can help prevent and treat non-small cell lung cancer. (2014) (49)
Production of 3R-hydroxy-polyenoic fatty acids by the yeast Dipodascopsis uninucleata (1997) (49)
Synthesis of the Polycyclopropane Antibiotic FR-900848 via the Horeau Gambit (1996) (49)
Stereospecific cross-coupling of alpha-(thiocarbamoyl)organostannanes with alkenyl, aryl, and heteroaryl iodides. (2007) (49)
Fluorescent HPLC assay for 20-HETE and other P-450 metabolites of arachidonic acid. (2000) (48)
Novel hypothalamic arachidonate products stimulate somatostatin release from the median eminence. (1983) (48)
Regulation of Diacylglycerol Kinase α by Phosphoinositide 3-Kinase Lipid Products* (2003) (48)
Androgen-Dependent Hypertension Is Mediated by 20-Hydroxy-5,8,11,14-Eicosatetraenoic Acid–Induced Vascular Dysfunction: Role of Inhibitor of &kgr;B Kinase (2011) (48)
Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle. (2007) (48)
Determination of trans-arachidonic acid isomers in human blood plasma. (2004) (48)
The synthesis of 20-HETE in small porcine coronary arteries antagonizes EDHF-mediated relaxation. (2005) (48)
12(R)-hydroxyeicosatrienoic acid, a potent chemotactic and angiogenic factor produced by the cornea. (1991) (47)
Electrooxidative cyclization of laudanosine. A novel nonphenolic coupling reaction [31] (1971) (47)
Electrooxidative cyclization of 1-benzyltetrahydroisoquinolines. A novel nonphenol coupling reaction (1973) (47)
Electrooxidative cyclization of 1-benzyltetrahydroisoquinolines. A novel nonphenol coupling reaction (1973) (47)
Soluble epoxide hydrolase inhibitor, AUDA, prevents early salt-sensitive hypertension. (2008) (47)
11,12-epoxyeicosatrienoic acid stimulates heme-oxygenase-1 in endothelial cells. (2007) (47)
Kinetic profile of the rat CYP4A isoforms: arachidonic acid metabolism and isoform-specific inhibitors. (1999) (47)
Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels. (2009) (47)
Cytochrome P-450 ω-hydroxylase: a potential O2 sensor in rat arterioles and skeletal muscle cells (2001) (46)
Stereospecific α-alkoxystannane couplings with acyl chlorides : total synthesis of (+)-goniofufurone (1993) (46)
The mechanistic plurality of cytochrome P-450 and its biological ramifications. (1984) (46)
Role of cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells. (2008) (46)
Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production. (2006) (46)
Cytochrome P450 and the Metabolism of Arachidonic Acid and Oxygenated Eicosanoids (1995) (46)
20-HETE modulates myogenic response of skeletal muscle resistance arteries from hypertensive Dahl-SS rats. (2001) (45)
16(R)-hydroxy-5,8,11,14-eicosatetraenoic acid, a new arachidonate metabolite in human polymorphonuclear leukocytes. (2000) (45)
Two distinct pathways account for EDHF‐dependent dilatation in the gracilis artery of dyslipidaemic hApoB+/+ mice (2005) (45)
Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy. (2015) (45)
20-HETE relaxes bovine coronary arteries through the release of prostacyclin. (1998) (45)
Resolution of epoxyeicosatrienoate enantiomers by chiral phase chromatography. (1989) (45)
The CYP450 hydroxylase pathway contributes to P2X receptor-mediated afferent arteriolar vasoconstriction. (2001) (45)
Influence of a fibric acid type of hypolipidemic agent on the oxidative metabolism of arachidonic acid by liver microsomal cytochrome P-450. (1985) (44)
GPR40 is a low-affinity epoxyeicosatrienoic acid receptor in vascular cells (2018) (44)
A one-pot synthesis of pyrido[2,3-b][1,4]oxazin-2-ones. (2003) (44)
An Adjacent Pair of Human NUDT Genes on Chromosome X Are Preferentially Expressed in Testis and Encode Two New Isoforms of Diphosphoinositol Polyphosphate Phosphohydrolase* (2002) (44)
Pd-catalyzed cross-coupling of α-(acyloxy)-tri-n-butylstannanes with alkenyl, aryl, and heteroaryl electrophiles. (2011) (44)
Transfection of CYP4A1 cDNA increases vascular reactivity in renal interlobar arteries. (2003) (44)
Structural determinants of active site binding affinity and metabolism by cytochrome P450 BM-3. (2001) (44)
Homocoupling of alkyl-, alkenyl-, and arylboronic acids (2002) (43)
Electrophilic alpha-thiocyanation of chiral and achiral N-acyl imides. A convenient route to 5-substituted and 5,5-disubstituted 2,4-thiazolidinediones. (2008) (43)
Rhodium catalyzed synthesis of isoindolinones via C-H activation of N-benzoylsulfonamides. (2012) (43)
Role of B-type natriuretic peptide in epoxyeicosatrienoic acid-mediated improved post-ischaemic recovery of heart contractile function. (2009) (43)
5,6-Epoxyeicosatrienoic Acid Mediates the Enhanced Renal Vasodilation to Arachidonic Acid in the SHR (2003) (42)
Analysis of oxidized glycerophosphocholine lipids using electrospray ionization mass spectrometry and microderivatization techniques. (2000) (42)
Enantioselective, organocatalytic reduction of ketones using bifunctional thiourea-amine catalysts. (2010) (42)
Role of CYP epoxygenases in A2A AR-mediated relaxation using A2A AR-null and wild-type mice. (2008) (42)
Phosphorylation of a Synaptic Vesicle-associated Protein by an Inositol Hexakisphosphate-regulated Protein Kinase* (2001) (42)
20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells. (2009) (42)
Triphenylphosphine hydrobromide: A mild and efficient catalyst for tetrahydropyranylation of tertiary alcohols (1988) (42)
ω-Oxidation of 20-Hydroxyeicosatetraenoic Acid (20-HETE) in Cerebral Microvascular Smooth Muscle and Endothelium by Alcohol Dehydrogenase 4* (2005) (42)
20-Hydroxyeicosatetraenoic acid is a potent dilator of mouse basilar artery: role of cyclooxygenase. (2006) (42)
Agonists of epoxyeicosatrienoic acids reduce infarct size and ameliorate cardiac dysfunction via activation of HO-1 and Wnt1 canonical pathway. (2015) (42)
Inhibition of telomerase by BIBR 1532 and related analogues. (2003) (41)
Arachidonic acid directly activates members of the mitogen-activated protein kinase superfamily in rabbit proximal tubule cells. (2001) (41)
Vascular CO Counterbalances the Sensitizing Influence of 20-HETE on Agonist-Induced Vasoconstriction (2004) (41)
Heme Oxygenase (HO-1) Rescue of Adipocyte Dysfunction in HO-2 Deficient Mice via Recruitment of Epoxyeicosatrienoic Acids (EETs) and Adiponectin (2012) (41)
Stereospecific dehydrative alkylation of bis-sulfones: synthesis of a lesser tea tortrix pheromone (1993) (41)
Epoxyeicosatrienoic Acid–Mediated Renal Vasodilation to Arachidonic Acid Is Enhanced in SHR (2001) (41)
Metabolism of arachidonic acid by rat adrenal glomerulosa cells: synthesis of hydroxyeicosatetraenoic acids and epoxyeicosatrienoic acids. (1991) (41)
Enol ethers: preparation and synthetic applications (1985) (41)
Renal microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid. (1988) (41)
Eicosanoid Regulation of Vascular Endothelial Growth Factor Expression and Angiogenesis in Microvessel Endothelial Cells* (2002) (40)
Iridium-catalyzed (Z)-trialkylsilylation of terminal olefins. (2010) (40)
Heme oxygenase-derived carbon monoxide restores vascular function in type 1 diabetes. (2008) (40)
Expression of CYP4A1 in U251 Human Glioma Cell Induces Hyperproliferative Phenotype in Vitro and Rapidly Growing Tumors in Vivo (2008) (40)
Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids. (2007) (39)
Effects of selective inhibition of cytochrome P-450 omega-hydroxylases and ischemic preconditioning in myocardial protection. (2006) (39)
8,9-Epoxyarachinodic acid: a cytochrome P-450 metabolite (1982) (39)
Role of endogenous CYP450 metabolites of arachidonic acid in maintaining the glomerular protein permeability barrier. (2007) (39)
Regioselective de-O-benzylation of monosaccharides (2002) (39)
Additions and Corrections, "Copper(I)-Promoted Thiophenoxide Ionization in Solution. A Simple Synthesis of Vinyl Phenyl Sulfides." (1975) (39)
Acylation of Glucosaminyl Phosphatidylinositol Revisited (1996) (39)
Enantiospecific total synthesis of a novel arachidonic acid metabolite 3-hydroxyeicosatetraenoic acid (1998) (39)
Evidence for role of epoxyeicosatrienoic acids in mediating ischemic preconditioning and postconditioning in dog. (2009) (39)
20-HETE Activates the Transcription of Angiotensin-Converting Enzyme via Nuclear Factor-κB Translocation and Promoter Binding (2016) (38)
Activation of nuclear factor kappa B and oncogene expression by 12(R)-hydroxyeicosatrienoic acid, an angiogenic factor in microvessel endothelial cells. (1994) (38)
P450BM-3: absolute configuration of the primary metabolites of palmitic acid. (1999) (38)
The protective effect of astrocyte-derived 14,15-epoxyeicosatrienoic acid on hydrogen peroxide-induced cell injury in astrocyte-dopaminergic neuronal cell line co-culture (2012) (38)
Regulation of synthesis of prostacyclin and HETEs in human endothelial cells. (1989) (38)
Increases in plasma trans-EETs and blood pressure reduction in spontaneously hypertensive rats. (2011) (38)
Inhibition of carcinoma cell motility by epoxyeicosatrienoic acid (EET) antagonists (2010) (37)
Arachidonic acid monooxygenase: Genetic and biochemical approaches to physiological/pathophysiological relevance. (2015) (37)
A novel pool of rat liver inositol and ethanolamine phospholipids contains epoxyeicosatrienoic acids (EETs). (1987) (37)
Absolute configuration of epoxyeicosatrienoic acids (EETs) formed during catalytic oxygenation of arachidonic acid by purified rat liver microsomal cytochrome P-450 (1984) (37)
Palladium mediated allylic mitsunobu displacement: stereocontrolled synthesis of hepoxilin A3 and trioxilin A3 methyl esters (1992) (37)
20-HETE can act as a nonhypoxic regulator of HIF-1alpha in human microvascular endothelial cells. (2009) (37)
Chiral α,β-Dialkoxy- and α-Alkoxy-β-aminostannanes: Preparation and Copper-Mediated Cross-Coupling (2003) (37)
Red blood cells: reservoirs of cis- and trans-epoxyeicosatrienoic acids. (2005) (37)
Development of a Primary Human Co-Culture Model of Inflamed Airway Mucosa (2017) (37)
Decreased Levels of Cytochrome P450 2E1–Derived Eicosanoids Sensitize Renal Arteries to Constrictor Agonists in Spontaneously Hypertensive Rats (2005) (37)
Effects of high-salt diet on CYP450-4A omega-hydroxylase expression and active tone in mesenteric resistance arteries. (2005) (36)
A convenient synthesis of unsymmetric polyfluoroethers (1994) (36)
Stereocontrolled synthesis of α-amino-α'-alkoxy ketones by a copper-catalyzed cross-coupling of peptidic thiol esters and α-alkoxyalkylstannanes. (2011) (36)
20-HETE synthesis inhibition promotes cerebral protection after intracerebral hemorrhage without inhibiting angiogenesis (2019) (36)
Adrenic Acid Metabolites as Endogenous Endothelium-Derived and Zona Glomerulosa-Derived Hyperpolarizing Factors (2010) (36)
A Convenient Preparation of Alkyl Halides and Cyanides from Alcohols by Modification of the Mitsunobu Procedure (1985) (36)
Microwave-assisted one-pot synthesis of benzo[b][1,4]thiazin-3(4H)-ones via Smiles rearrangement (2008) (36)
A 20-HYDROXYEICOSATETRAENOIC ACID AGONIST, N-[20-HYDROXYEICOSA-5(Z),14(Z)-DIENOYL]GLYCINE, OPPOSES THE FALL IN BLOOD PRESSURE AND VASCULAR REACTIVITY IN ENDOTOXIN-TREATED RATS (2008) (36)
16(R)-Hydroxyeicosatetraenoic Acid, a Novel Cytochrome P450 Product of Arachidonic Acid, Suppresses Activation of Human Polymorphonuclear Leukocytes and Reduces Intracranial Pressure in a Rabbit Model of Thromboembolic Stroke (2000) (36)
Restoration of normal vascular relaxation mechanisms in cerebral arteries by chromosomal substitution in consomic SS.13BN rats. (2005) (36)
The Cytochrome P450 4A/F-20-Hydroxyeicosatetraenoic Acid System: A Regulator of Endothelial Precursor Cells Derived from Human Umbilical Cord Blood (2011) (35)
8,9-Epoxyeicosatrienoic acid protects the glomerular filtration barrier. (2009) (35)
Selective Enrichment of Thiophosphorylated Polypeptides as a Tool for the Analysis of Protein Phosphorylation* (2003) (35)
Bromo-boronolactonization of olefins. (2001) (35)
Vascular characterization of mice with endothelial expression of cytochrome P450 4F2 (2014) (35)
Reactivity of α,β-unsaturated acetals and ketals toward organolithium reagents in pentane (1984) (35)
Alternative pathways for Heck intermediates: palladium-catalyzed oxyarylation of homoallylic alcohols. (2011) (35)
Cytochrome P-450 ω-hydroxylase senses O2 in hamster muscle, but not cheek pouch epithelium, microcirculation. (1999) (35)
Epoxyeicosatrienoic intervention improves NAFLD in leptin receptor deficient mice by an increase in PGC1α-HO-1-PGC1α-mitochondrial signaling. (2019) (34)
Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts. (2010) (34)
20-hydroxyeicosatetraenoic acid (20-HETE): structural determinants for renal vasoconstriction. (2003) (34)
Transformations of X (C, O, N)-CN Bonds: Cases of Selective X (C, O, N)-C Activation. (2014) (34)
Modified pyridinium chlorochromate oxidation of aldehydes to carbamoyl azides/acyl azides or carboxylic acids (1988) (34)
Role of arachidonic acid lipoxygenase metabolites in acetylcholine-induced relaxations of mouse arteries. (2011) (34)
Downregulation of PGC-1α Prevents the Beneficial Effect of EET-Heme Oxygenase-1 on Mitochondrial Integrity and Associated Metabolic Function in Obese Mice (2016) (34)
Dimethylthiocarbamate (DMTC): an alcohol protecting group. (2003) (34)
Relative contribution of cyclooxygenases, epoxyeicosatrienoic acids, and pH to the cerebral blood flow response to vibrissal stimulation. (2012) (34)
Structural determinants and specificities for ROMK1-phosphoinositide interaction. (2002) (34)
Practical, enantiospecific syntheses of 14,15-EET and leukotoxin B (vernolic acid) (2001) (34)
Synthesis of 12(S),20-, 12(S),19(R)-, and 12(S),19(S)-dihydroxyeicosa-cis-5,8,14-trans-10-tetraenoic acids, metabolites of 12(S)-HETE (1986) (33)
2-Cyanopyridazin-3(2H)-ones: effective and chemoselective electrophilic cyanating agents (2005) (33)
Hydrolysis of cis- and trans-Epoxyeicosatrienoic Acids by Rat Red Blood Cells (2008) (33)
ROS‐sensitive cytochrome P450 activity maintains endothelial dilatation in ageing but is transitory in dyslipidaemic mice (2006) (33)
C-Glycosides: Pd/Cu co-catalyzed thiocarboxylation of stannyl glucopyranosides (1995) (33)
Mechanism of rat mesenteric arterial KATP channel activation by 14,15-epoxyeicosatrienoic acid. (2006) (33)
Diphospho‐myo‐inositol phosphates in Dictyostelium and Polysphondylium: identification of a new bisdiphospho‐myo‐inositol tetrakisphosphate (1998) (33)
Airway synthesis of 20-hydroxyeicosatetraenoic acid: metabolism by cyclooxygenase to a bronchodilator. (1999) (33)
Oxidation and keto reduction of 12-hydroxy-5,8,10,14-eicosatetraenoic acids in bovine corneal epithelial microsomes. (1994) (33)
Studies of Anandamide Accumulation Inhibitors in Cerebellar Granule Neurons: Comparison to Inhibition of Fatty Acid Amide Hydrolase (2007) (32)
Catalyst-Controlled Diastereoselective Synthesis of Cyclic Amines via C-H Functionalization. (2017) (32)
Protective effect of 20-HETE inhibition in a model of oxygen-glucose deprivation in hippocampal slice cultures. (2012) (32)
Suzuki-Miyaura cross-coupling of lithium n-alkylborates (2001) (32)
Metabolism of 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid and other hydroxylated fatty acids by the reductase pathway in porcine polymorphonuclear leukocytes. (1990) (32)
Chromium vinylidene carbenoids: generation, characterization, and reactivity. First evidence for an internal proton return phenomenon with vinylidene carbenoids. (2001) (31)
20-125Iodo-14,15-Epoxyeicosa-5(Z)-enoic Acid: a High-Affinity Radioligand Used to Characterize the Epoxyeicosatrienoic Acid Antagonist Binding Site (2009) (31)
Metabolism of arachidonic acid to epoxyeicosatrienoic acids by human granulosa cells may mediate steroidogenesis. (1993) (31)
Elevated 20-HETE impairs coronary collateral growth in metabolic syndrome via endothelial dysfunction. (2017) (31)
Altered Mechanisms Underlying Hypoxic Dilation of Skeletal Muscle Resistance Arteries of Hypertensive versus Normotensive Dahl Rats (2001) (31)
20-HETE-induced nitric oxide production in pulmonary artery endothelial cells is mediated by NADPH oxidase, H2O2, and PI3-kinase/Akt. (2010) (31)
Hypoxia stimulates the synthesis of cytochrome P450-derived inflammatory eicosanoids in rabbit corneal epithelium. (1998) (31)
Modulation of erythropoiesis by novel human bone marrow cytochrome P450- dependent metabolites of arachidonic acid (1991) (31)
Biochemical and molecular characteristics of the cytochrome P450 arachidonic acid monooxygenase. (2000) (31)
Epoxygenase metabolites of arachidonic acid affect electrophysiologic properties of rat tracheal epithelial cells1. (1998) (30)
Endogenously produced 20-HETE modulates myogenic and TGF response in microperfused afferent arterioles. (2013) (30)
Enantiospecific synthesis of D-myo-inositol 1,4,5-trisphosphate from (-)-quinic acid (1989) (30)
NADPH-dependent microsomal metabolism of 14,15-epoxyeicosatrienoic acid to diepoxides and epoxyalcohols. (1988) (30)
Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase. (2006) (30)
Mitogenic Activity and Signaling Mechanism of 2-(14,15- Epoxyeicosatrienoyl)Glycerol, a Novel Cytochrome P450 Arachidonate Metabolite (2007) (30)
Hepoxilin A3 Facilitates Neutrophilic Breach of Lipoxygenase-Expressing Airway Epithelial Barriers (2012) (30)
High-fat diet-induced obesity and insulin resistance in CYP4a14-/- mice is mediated by 20-HETE. (2018) (30)
NO and NO-independent mechanisms mediate ETB receptor buffering of ET-1-induced renal vasoconstriction in the rat. (2005) (30)
Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides (2011) (30)
Rhodium(I)-catalyzed N-CN bond cleavage: intramolecular β-cyanation of styrenes. (2013) (30)
High-salt diet enhances mouse aortic relaxation through adenosine A2A receptor via CYP epoxygenases. (2009) (29)
Relative Contributions of Cyclooxygenase- and Cytochrome P450 ω-Hydroxylase-Dependent Pathways to Hypoxic Dilation of Skeletal Muscle Resistance Arteries (2001) (29)
14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) Surrogates: Carboxylate Modifications (2014) (29)
Total Synthesis of (±)-Halomon by a Johnson-Claisen Rearrangement. (1998) (29)
Stable 5,6-Epoxyeicosatrienoic Acid Analog Relaxes Coronary Arteries Through Potassium Channel Activation (2005) (29)
Exaggerated Response to Adenosine in Kidneys from High Salt Fed Rats: Role of Epoxyeicosatrienoic Acids (EETs) (2004) (29)
Impaired Endothelial Function and Microvascular Asymmetrical Dimethylarginine in Angiotensin II–Infused Rats: Effects of Tempol (2010) (29)
Room temperature, open-flask C–H arylation of electron-deficient heteroarenes with triazenes: rapid synthesis of heterobiaryls (2014) (29)
A novel treatment strategy for sepsis and septic shock based on the interactions between prostanoids, nitric oxide, and 20-hydroxyeicosatetraenoic acid. (2012) (29)
Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization (2017) (29)
PPARγ signaling is required for mediating EETs protective effects in neonatal cardiomyocytes exposed to LPS (2014) (29)
The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production. (2018) (28)
Orally Active Epoxyeicosatrienoic Acid Analogs. (2017) (28)
Inhibition of Smooth Muscle Proliferation by Urea-Based Alkanoic Acids via Peroxisome Proliferator-Activated Receptor &agr;–Dependent Repression of Cyclin D1 (2006) (28)
Enalapril Treatment Alters the Contribution of Epoxyeicosatrienoic Acids but Not Gap Junctions to Endothelium-Derived Hyperpolarizing Factor Activity in Mesenteric Arteries of Spontaneously Hypertensive Rats (2009) (28)
Inhibition of renin release by 14,15-epoxyeicosatrienoic acid in renal cortical slices. (1990) (28)
Total synthesis of the cytochrome P-450 epoxygenase metabolites 5(R),6(S)-, 5(S),6(R)-, and 14(R),15(S)-epoxyeicosatrienoic acid (EET) and hydration products 5(R),6(R)- and 14(R),15(R)-dihydroxyeicosatrienoic acid (DHET) (1985) (28)
TOTAL SYNTHESIS OF ERYTHROMYCINS. 5. TOTAL SYNTHESIS OF ERYTHRONOLIDE A (1980) (28)
P2X Receptor-Stimulated Calcium Responses in Preglomerular Vascular Smooth Muscle Cells Involves 20-Hydroxyeicosatetraenoic Acid (2004) (28)
A convenient synthesis of 2-tetrahydrofuranyl ethers. (2000) (28)
Role of 20-HETE in the impaired myogenic and TGF responses of the Af-Art of Dahl salt-sensitive rats. (2014) (28)
Differential Cleavage of Arylmethyl Ethers: Reactivity of 2,6‐Dimethoxybenzyl Ethers (2001) (28)
Metabolism of arachidonic acid by canine polymorphonuclear leukocytes synthesis of lipoxygenase and omega-oxidized metabolites. (1996) (28)
Epoxyeicosatrienoic Acid Analog Decreases Renal Fibrosis by Reducing Epithelial-to-Mesenchymal Transition (2017) (28)
High potassium intake enhances the inhibitory effect of 11,12-EET on ENaC. (2010) (28)
Arachidonate epoxygenase: Total synthesis of both enantiomers of 8,9- and 11,12-epoxyricosatrienoic acid (1986) (27)
20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension. (2013) (27)
Insulin second messengers : synthesis of 6-O-(2-amino-2-deoxy-α-D-glucopyranosyl)-D-chiro-inositol-1-phosphate (1993) (27)
Cu2S Mediated Cross-Coupling of α-Stannylepoxides (1997) (27)
Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKKβ/IκB-α/NF-κB pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock (2014) (27)
Effect of 14,15-epoxyeicosatrienoic acid infusion on blood pressure in normal and hypertensive rats. (1990) (27)
Picolinate Directed Arene meta-C-H Amination via FeCl3 Catalysis. (2020) (27)
Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD. (2009) (26)
Stereoselective transformations of trihalomethylcarbinols induced by chromous chloride. (2005) (26)
Differential Effect of Cytochrome P‐450 ω‐Hydroxylase Inhibition on O2‐Induced Constriction of Arterioles in SHR With Early and Established Hypertension (2001) (26)
Molecular basis for the ω-regiospecificity of the CYP4A2 and CYP4A3 fatty acid hydroxylases (2000) (26)
5,14-HEDGE, a 20-HETE mimetic, reverses hypotension and improves survival in a rodent model of septic shock: contribution of soluble epoxide hydrolase, CYP2C23, MEK1/ERK1/2/IKKβ/IκB-α/NF-κB pathway, and proinflammatory cytokine formation. (2013) (26)
20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice (2016) (26)
Contribution of 20-HETE to Augmented Myogenic Constriction in Coronary Arteries of Endothelial NO Synthase Knockout Mice (2005) (26)
Effects of metabolites of leukotriene B4 on human neutrophil migration and cytosolic calcium levels. (1996) (26)
Facile Reduction of Carboxylic Acids, Esters, Acid Chlorides, Amides and Nitriles to Alcohols or Amines Using NaBH4/BF3·Et2O (2004) (26)
Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension. (2015) (26)
A convenient synthesis of (Z)-1-chloro-1-alkenes and (Z)-1-chloro-2-alkoxy-1-alkenes (2002) (26)
Role of changes in renal hemodynamics and P-450 metabolites of arachidonic acid in the reversal of one-kidney, one clip hypertension (1995) (26)
Association of the inositol (1,4,5)-trisphosphate receptor ligand binding site with phosphatidylinositol (4,5)-bisphosphate and adenophostin A. (2000) (26)
A synthetic analogue of 20-HETE, 5,14-HEDGE, reverses endotoxin-induced hypotension via increased 20-HETE levels associated with decreased iNOS protein expression and vasodilator prostanoid production in rats. (2009) (26)
Metabolism of adrenic acid to vasodilatory 1α,1β-dihomo-epoxyeicosatrienoic acids by bovine coronary arteries (2007) (25)
Arachidonate epoxygenase: inhibitors and metabolite analogues (1985) (25)
Intrarenal cytochrome P-450 metabolites of arachidonic acid in the regulation of the nonclipped kidney function in two-kidney, one-clip Goldblatt hypertensive rats (2010) (25)
An intramolecular passerini reaction: Synthesis of hydrastine. (1981) (25)
Epoxygenation of arachidonic acid by rat anterior pituitary microsomal fractions (1984) (25)
Cytochrome P450 and the Metabolism and Bioactivation of Arachidonic Acid and Eicosanoids (2005) (25)
Characterization of cytochrome P-450-dependent arachidonic acid metabolism in rabbit intestine. (1993) (25)
Identification of 15-hydroxy-11,12-epoxyeicosatrienoic acid as a vasoactive 15-lipoxygenase metabolite in rabbit aorta. (2008) (25)
20-Carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors α and γ (2007) (25)
Cytochrome P450‐Dependent Arachidonic Acid Metabolites, 19− and 20‐Hydroxyeicosatetraenoic Acids, Enhance Sodium‐Potassium ATPase Activity in Vascular Smooth Muscle (1990) (24)
Effects of epoxyicosatrienoic acids on ion transport in the rabbit cortical collecting tubule (1984) (24)
Androgen-induced hypertension in angiotensinogen deficient mice: role of 20-HETE and EETS. (2015) (24)
11(R),12(S),15(S)-trihydroxyeicosa-5(Z),8(Z),13(E)-trienoic acid: an endothelium-derived 15-lipoxygenase metabolite that relaxes rabbit aorta. (2008) (24)
Benzothiazoline: The Surrogate of Hantzsch Ester (2011) (24)
Total synthesis of (+)-dihydrocompactin (1984) (24)
Stereospecific synthesis of EET metabolites via Suzuki-Miyaura coupling (2001) (24)
Intramolecular mitsunobu displacement with carbon nucleophiles: Preparation of α-nitrocyclopropanes (1992) (23)
Synthesis and stereochemical assignment of FR252921, a promising immunosuppressant. (2007) (23)
Factors Mediating Remote Preconditioning of Trauma in the Rat Heart (2013) (23)
Two-carbon elongation/annulation of alcohols to nitriles (1995) (23)
Effect of diabetes mellitus on endotoxin-induced lung injury. (1999) (23)
Failure to upregulate the adenosine2A receptor-epoxyeicosatrienoic acid pathway contributes to the development of hypertension in Dahl salt-sensitive rats. (2008) (23)
Transfection of Cytochrome P4504B1 into the Cornea Increases Angiogenic Activity of the Limbal Vessels (2005) (23)
Enantiospecific total synthesis of 8- and 12-hydroxyeicosatetraenoic acid (1986) (23)
Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria. (2017) (23)
Total synthesis of vineomycinone B2 methyl ester via double Bradsher cyclization (1991) (23)
Deficiency in the Formation of 20-Hydroxyeicosatetraenoic Acid Enhances Renal Ischemia-Reperfusion Injury. (2015) (23)
Salt modulates vascular response through adenosine A2A receptor in eNOS-null mice: role of CYP450 epoxygenase and soluble epoxide hydrolase (2011) (23)
Cu(II)-Mediated N-H and N-Alkyl Aryl Amination and Olefin Aziridination. (2019) (22)
A synthetic epoxyeicosatrienoic acid analogue prevents the initiation of ischemic acute kidney injury (2019) (22)
ALKYLTHIOETHER SYNTHESIS VIA IMIDAZOLE MEDIATED MITSUNOBU CONDENSATION (1999) (22)
Synthesis of enantioenriched alpha-(hydroxyalkyl)-tri-n-butylstannanes. (2008) (22)
A convenient preparation of 3-substituted furans: synthesis of perillene and dendrolasin. (2002) (22)
Epoxyeicosatrienoic Acid Inhibition Alters Renal Hemodynamics During Pregnancy (2006) (22)
Epoxyeicosatrienoic acid analog attenuates angiotensin II hypertension and kidney injury (2014) (22)
Wortmannin and LY294002 inhibit the insulin-induced down-regulation of IRS-1 in 3T3-L1 adipocytes (1995) (22)
Synthesis of 12(R),13(S)-oxido-9z-octadecenoic (vernolic) and 13(S)-hydroxy-9z, 11E-octadecadienoic (coriolic) acids (1986) (22)
Reductive lithiation of bis-phenylsulfones (1994) (22)
CHIRAL ACETALS : STEREOCONTROLLED SYNTHESES OF 16-,17-, AND 18-HYDROXYEICOSATETRAENOIC ACIDS, CYTOCHROME P-450 ARACHIDONATE METABOLITES (1996) (22)
An Economic and Practical Synthesis of the 2-Tetrahydrofuranyl Ether Protective Group. (2006) (21)
Taxol total synthesis: Preparation of a chiral ring a moiety via biomimetic cyclization and evaluation of a tandem nitrile oxide strategy for rings B/C (1995) (21)
Recombinant p42IP4, a brain-specific 42-kDa high-affinity Ins(1,3,4,5)P4 receptor protein, specifically interacts with lipid membranes containing Ptd-Ins(3,4,5)P3. (1999) (21)
Angiotensin II Regulates Adrenal Vascular Tone Through Zona Glomerulosa Cell–Derived EETs and DHETs (2011) (21)
Two pharmacological epoxyeicosatrienoic acid-enhancing therapies are effectively antihypertensive and reduce the severity of ischemic arrhythmias in rats with angiotensin II-dependent hypertension (2018) (21)
Hyperbaric oxygenation modulates vascular reactivity to angiotensin-(1-7) in diabetic rats: Potential role of epoxyeicosatrienoic acids (2015) (21)
Epoxyeicosatrienoic acid analogue mitigates kidney injury in a rat model of radiation nephropathy. (2016) (21)
Fe(0)-mediated synthesis of tri- and tetra-substituted olefins from carbonyls: an environmentally friendly alternative to Cr(II). (2006) (21)
Stable EET urea agonist and soluble epoxide hydrolase inhibitor regulate rat pulmonary arteries through TRPCs (2011) (21)
20‐HETE Contributes to Myogenic Activation of Skeletal Muscle Resistance Arteries in Brown Norway and Sprague‐Dawley Rats (2001) (21)
Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase. (2010) (21)
Isoquinolinium cycloadditions: regiospecific synthesis of 1-naphthaldehydes and conversion to 1-naphthylamines (1982) (21)
Electrooxidative synthesis of morphinandienones from 1-benzyltetrahydroisoquinolines☆ (1974) (21)
8,9-Epoxyeicosatrienoic acid analog protects pulmonary artery smooth muscle cells from apoptosis via ROCK pathway. (2010) (21)
SYNTHESIS AND STRUCTURE OF CELLULAR MEDIATORS : INOSITOL POLYPHOSPHATE DIPHOSPHATES (1995) (21)
Sulfur ylide vinylation of halides and mesylates (1994) (20)
Impairment of flow-induced dilation of skeletal muscle arterioles with elevated oxygen in normotensive and hypertensive rats. (2000) (20)
Eicosanoid biosynthesis : Differential inhibition of cytochrome P450 epoxygenase and ω-hydroxylase (1997) (20)
Microsomal cytochrome P450 and eicosanoid metabolism. (2002) (20)
20-HETE Contributes to Myogenic Activation of Skeletal Muscle Resistance Arteries in Brown Norway and Sprague–Dawley Rats (2001) (20)
Transfection of CYP4A1 cDNA decreases diameter and increases responsiveness of gracilis muscle arterioles to constrictor stimuli. (2004) (20)
Effect of epoxyeicosatrienoic acids on growth hormone release from somatotrophs. (1989) (20)
Palladium catalyzed cross-coupling and tandem cyclization-coupling of α-halo(thio)ethers with organotins (1992) (20)
Identification of 13-Hydroxy-14,15-epoxyeicosatrienoic Acid as an Acid-stable Endothelium-derived Hyperpolarizing Factor in Rabbit Arteries* (2009) (20)
Isoquinolinium cycloadditions: total synthesis of (.+-.)-14-epicorynoline and O-methylarnottianamide (1983) (20)
Elevated 20-HETE in metabolic syndrome regulates arterial stiffness and systolic hypertension via MMP12 activation. (2018) (20)
Detection of 20-hydroxyeicosatetraenoic acid in rat urine. (1991) (20)
Novel Roles of Epoxyeicosanoids in Regulating Cardiac Mitochondria (2016) (20)
Synthesis of trioxilin B3 (1988) (20)
Effects of protein tyrosine kinase and protein tyrosine phosphatase on apical K(+) channels in the TAL. (2001) (20)
20-HETE contributes to ischemia-induced angiogenesis. (2016) (20)
Preparation of N-tBoc L-glutathione dimethyl and di-tert-butyl esters: versatile synthetic building blocks. (2007) (20)
Role of prostanoids and 20-HETE in mediating oxygen-induced constriction of skeletal muscle resistance arteries. (2001) (20)
Stereospecific synthesis of trans-arachidonic acids. (2001) (20)
Total synthesis of the 5-methylenephosphonate analogue of D-myo-inositol 1,4,5-trisphosphate (1990) (20)
Cytochrome P450 epoxygenases provide a novel mechanism for penile erection (2006) (20)
Novel synthesis of pyridazino[4,5-b][1,4]oxazin-3,8-diones (2003) (19)
Synthesis of 2- and 5-diphospho-myo-inositol pentakisphosphate (2- and 5-PP-InsP5), intracellular mediators (1997) (19)
Novel formation of 1,3-oxazepine heterocycles via palladium-catalyzed intramolecular coupling reaction (2006) (19)
20-HETE mediates the effect of parathyroid hormone and protein kinase C on renal phosphate transport. (1998) (19)
14,15-Dihydroxy-eicosa-5(Z)-enoic Acid Selectively Inhibits 14,15-Epoxyeicosatrienoic Acid-Induced Relaxations in Bovine Coronary Arteries (2011) (19)
Modulation of arteriolar blood flow by inhibitors of arachidonic acid oxidation after thermal injury: possible role for a novel class of vasodilator metabolites. (1988) (19)
Regulation of diacylglycerol kinase alpha by phosphoinositide 3-kinase lipid products. (2003) (19)
Metabolism of 12(R)-hydroxy-5,8,10,14-eicosatetraenoic acid (12(R)-HETE) in corneal tissues: formation of novel metabolites. (1991) (19)
One-pot Synthesis of Symmetrical 1,4-Disubstituted Piperazine-2,5-diones (2004) (19)
Contribution of vasoactive eicosanoids and nitric oxide production to the effect of selective cyclooxygenase-2 inhibitor, NS-398, on endotoxin-induced hypotension in rats. (2010) (19)
Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase‐null mice through cyp2j‐epoxygenases and PPARγ (2013) (19)
Asymmetric synthesis of the stereoisomers of 11,12,15(S)-trihydroxyeicosa-5(Z),8(Z),13(E)-trienoic acid, a potent endothelium-derived vasodilator. (2004) (19)
3-Hydroxyleukotriene B4 (3-OH-LTB4): Total Synthesis and Stereochemical Assignment. (1994) (19)
Alkaloids of the papaveraceae. XX. 2,9-Dimethoxy-3-hydroxypavinane, a new alkaloid from Argemone munita subsp. rotundata. (1973) (19)
Chiral cyclopropanes: Asymmetric synthesis of constanolactones A and B (2002) (18)
Concise syntheses of L-α-phosphatidyl-D-myo-inositol 3-phosphate (3- PIP), 5-phosphate (5-PIP), and 3,5-bisphosphate (3,5-PIP2) (2000) (18)
Metabolism of 12-hydroperoxyeicosatetraenoic acid to vasodilatory trioxilin C3 by rabbit aorta. (2003) (18)
Modulation of erythropoiesis by novel human bone marrow cytochrome P450-dependent metabolites of arachidonic acid. (1991) (18)
Reductive olefination of aldehydes via chromium Brook rearrangement. (2006) (18)
Cytochrome P 450 Eicosanoids are Activators of Peroxisome Proliferator-Activated Receptor (2007) (18)
Steroid-producing cells regulate arterial tone of adrenal cortical arteries. (2007) (18)
Identification and biological activity of dihydroleukotriene B4: a prominent metabolite of leukotriene B4 in the human lung. (1990) (18)
Glomerular autacoids stimulated by bradykinin regulate efferent arteriole tone. (2003) (18)
11,12,20-Trihydroxy-eicosa-8(Z)-enoic acid: a selective inhibitor of 11,12-EET-induced relaxations of bovine coronary and rat mesenteric arteries. (2012) (18)
Chromium vinylidene carbenoids: stereospecific synthesis of (Z)-2-chloroalk-2-en-1-ols. (2001) (18)
NS-398 reverses hypotension in endotoxemic rats: contribution of eicosanoids, NO, and peroxynitrite. (2013) (18)
Effects of oxo and dihydro metabolites of 12‐hydroxy‐5,8,10,14‐eicosatetraenoic acid on chemotaxis and cytosolic calcium levels in human neutrophils (1995) (17)
A preparation of benzylic and allylic boronates: Cross-coupling of aryl- and alkenylstannanes with bromomethylboronates (1999) (17)
Isomerization of epoxides to allylic alcohols using methylmagnesium N-cyclohexylisopropylamide (1986) (17)
Total synthesis of the ethanol inducible, proinflammatory autacoid 3(S)-hydroxy-leukotriene B4 (3-OH-LTB4) and analogues (1994) (17)
Not so EEZE: the 'EDHF' antagonist 14, 15 epoxyeicosa-5(Z)-enoic acid has vasodilator properties in mesenteric arteries. (2004) (17)
20-HETE Interferes with Insulin Signaling and Contributes to Obesity-Driven Insulin Resistance. (2020) (17)
Regio- and Enantioselective Catalytic Monoepoxidation of Conjugated Dienes: Synthesis of Chiral Allylic cis-Epoxides (2015) (17)
The epoxyeicosatrienoic acid analog PVPA ameliorates cyclosporine-induced hypertension and renal injury in rats. (2016) (17)
A highly stereospecific synthesis of (E)-α,β-unsaturated esters (2004) (17)
Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites. (2006) (17)
Heme oxygenase metabolites inhibit tubuloglomerular feedback in vivo. (2011) (17)
Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats (2016) (17)
Protection by 20-5,14-HEDGE against surgically induced ischemia reperfusion lung injury in rats. (2012) (17)
Vascular hepoxilin and trioxilins mediate vasorelaxation through TP receptor inhibition in mouse arteries (2017) (17)
Ruthenium catalyzed oxidative annulation with alkynes via cascade C-H/N-H bond functionalizations (2014) (16)
Modulation of V1-receptor-mediated renal vasoconstriction by epoxyeicosatrienoic acids. (2004) (16)
Stereochemistry of leukotriene B4 metabolites formed by the reductase pathway in porcine polymorphonuclear leukocytes: inversion of stereochemistry of the 12-hydroxyl group. (1990) (16)
Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs). (2005) (16)
Structural characterization of monohydroxyeicosatetraenoic acids and dihydroxy- and trihydroxyeicosatrienoic acids by ESI-FTICR (2008) (16)
Erratum: A functional phosphatidylinositol 3,4,5- trisphosphate/phosphoinositide binding domain in the clathrin adaptor AP-2 α subunit. Implications for the endocytic pathway (Journal of Biological Chemistry (1996) 271 (20922-20924)) (1996) (16)
Enantiospecific synthesis of methyl 11,12- and 14,15-epoxyeicosatrienoate (1984) (16)
Evaluation of cytochrome P450 4 family as mediator of phospholipase D activation in aortic vascular smooth muscle cells. (2005) (16)
Ring expansion/homologation--aldehyde condensation cascade using tert-trihalomethylcarbinols. (2006) (16)
Inhibition of the Adenosine2A Receptor-Epoxyeicosatrienoic Acid Pathway Renders Dahl Salt-Resistant Rats Hypertensive (2009) (16)
Synthesis and Structure Confirmation Of Compound D, A Proinflammatory Arachidonate Metabolite (1989) (16)
Arachidonic acid inhibits basolateral K channels in the cortical collecting duct via cytochrome P-450 epoxygenase-dependent metabolic pathways. (2008) (16)
Cytochrome P-450 omega-hydroxylase: a potential O(2) sensor in rat arterioles and skeletal muscle cells. (2001) (15)
Cytochrome P450-dependent arachidonate metabolites affect renal transport in the rabbit. (1993) (15)
Inhibition of 20-HETE abolishes the myogenic response during NOS antagonism in the ovine fetal pulmonary circulation. (2005) (15)
CYP4A/20-HETE regulates ischemia-induced neovascularization via its actions on endothelial progenitor and preexisting endothelial cells. (2019) (15)
Synthesis of alkyl nitronates via Mitsunobu condensation (1992) (15)
Infarct size-limiting effect of epoxyeicosatrienoic acid analog EET-B is mediated by hypoxia-inducible factor-1α via downregulation of prolyl hydroxylase 3. (2018) (15)
An efficient synthesis of [1,4]pyridazinooxazine[3,4-a]tetrahydro isoquinolines (2004) (15)
Cytochrome P-450 omega-hydroxylase senses O2 in hamster muscle, but not cheek pouch epithelium, microcirculation. (1999) (15)
Chromium-carbyne complexes: intermediates for organic synthesis. (2007) (15)
Stereoselective CrCl2-mediated condensation of aldehydes with functionalized 1,1,1-trichlorides: synthesis of trisubstituted (Z)-chloroolefins (2004) (15)
Epoxygenase eicosanoids: synthesis of tetrahydrofuran-diol metabolites and their vasoactivity. (2007) (15)
SmI2 mediated reductive addition of bis-phenylsulfones to ketones (1994) (15)
Synthesis and structure revision of the myo-inositol monophosphatase inhibitor L-671,776 (1997) (15)
A novel activity of microsomal epoxide hydrolase: metabolism of the endocannabinoid 2-arachidonoylglycerol (2014) (15)
Transition Metals Catalyzed Element-Cyano Bonds Activations (2014) (15)
Introgression of Brown Norway CYP4A genes on to the Dahl salt-sensitive background restores vascular function in SS-5(BN) consomic rats. (2013) (14)
Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria. (2017) (14)
Homologation of aldehydes using (phenylthiomethylene) triphenylarsorane: selective preparation of α-thiophenoxyepoxides and phenylthioenol ethers (1989) (14)
α-chlorovinylation: Synthesis of 2-chloropropenyl and propargyl alcohols (1999) (14)
Midkine Regulates BP through Cytochrome P450-Derived Eicosanoids. (2015) (14)
Cytochrome P 450-Derived Arachidonic Acid Metabolism in the Rat Kidney : Characterization of Selective Inhibitors 1 (1998) (14)
Eicosanoids derived from cytochrome P450 pathway of arachidonic acid and inflammatory shock. (2019) (14)
Transformation of 15-hete to 14,15-dihydroxyeicosatrienoic acid and 11,14,15- and 13,14,15-trihydroxyeicosatrienoic acid (1983) (14)
Preparation and Scope of a Remarkably Robust Primary Alcohol Protective Group (1994) (14)
Nucleophilic substitution at the acetalic center of mandelate 1,3-dioxolan-4-ones using magnesio-copper reagents: Application to the synthesis of chiral secondary alcohols. (1992) (14)
Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats (2019) (14)
Modulation of Vascular O2 Responses by Cytochrome 450‐4A ω‐Hydroxylase Metabolites In Dahl Salt‐Sensitive Rats (2009) (14)
Grignard additions to α,β-unsaturated dioxolanones: preparation of chiral allylic alcohols and protected α-hydroxy aldehydes (1996) (14)
A Convenient Synthesis of Pyrido[3,4-g]isoquinoline via ortho-Directed Metallation/Dimerization (1988) (14)
Synthetic studies on isoquinoline derivatives with multidrug resistance (MDR) modulating activity (2004) (14)
Conjugate addition of α-alkoxystannanes via in situ transmetalation using catalytic CuCN (1996) (14)
Overexpression of Cytochrome P 450 CYP 2 J 2 Protects against Hypoxia-Reoxygenation Injury in Cultured Bovine Aortic Endothelial Cells (2001) (14)
The Roles of Intrarenal 20-Hydroxyeicosatetraenoic and Epoxyeicosatrienoic Acids in the Regulation of Renal Function in Hypertensive Ren-2 Transgenic Rats (2007) (14)
Preparation and spectral properties of lipophilic fluorescein derivatives: Application to plasma low-density lipoprotein (1981) (14)
Synthesis of (S)-(+)-mevalonolactone and mevalonate analogues (1991) (14)
Regioselectivity of Pictet–Spengler cyclization: synthesis of halotetrahydroisoquinolines (2001) (14)
1,5-addition of dialkylcuprate reagents to alkylcyclopropyl ketones (1983) (14)
Environmentally benign perfluorooctanesulfonate alternatives using a Zn/CuI mediated Michael-type addition in imidazolium ionic liquids (2014) (14)
Resolution of dihydroxyeicosanoates and of dihydroxyeicosatrienoates by chiral phase chromatography. (1992) (14)
Regulation of calcium influx and catecholamine secretion in chromaffin cells by a cytochrome P450 metabolite of arachidonic acid. (1995) (13)
High dietary salt reduces the contribution of 20-HETE to arteriolar oxygen responsiveness in skeletal muscle. (2007) (13)
Antineutrophil strategies (1997) (13)
Preparation of l-α-phosphatidyl-d-myo-inositol 3-phosphate (3-PIP) and 3,5-bisphosphate (3,5-PIP2) (2000) (13)
Epoxyeicosatrienoic Acid Analog EET-A Blunts Development of Lupus Nephritis in Mice (2019) (13)
Direct anomeric substitution of pyranyl esters using organocopper reagents (1989) (13)
Upregulation of 20-HETE Synthetic Cytochrome P450 Isoforms by Oxygen–Glucose Deprivation in Cortical Neurons (2017) (13)
High Salt Diet Exacerbates Vascular Contraction in the Absence of Adenosine A2A Receptor (2014) (13)
Quantification of 20-hydroxyeicosatetraenoic acid by colorimetric competitive enzyme linked immunosorbent assay (2003) (13)
α-Haloenol Acetates: Versatile Reactants for Oxetan-2-one, Azetidin-2-one and Isoxazolidin-5-one Synthesis (2007) (13)
A synthesis of l-α-phosphatidyl-d-myo-inositol 4,5-bisphosphate (4,5-PIP2) and glyceryl lipid analogs (1999) (13)
20-carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors alpha and gamma. (2007) (13)
11,12 -Epoxyeicosatrienoic acid (11,12 EET) reduces excitability and excitatory transmission in the hippocampus (2017) (13)
Cardiovascular and renal actions of cytochrome P-450 metabolites of arachidonic acid. (1989) (12)
Phenol oxidation and biosynthesis. Part 26. Isonitriles in the synthesis of benzylisoquinoline derivatives (1979) (12)
Epoxyeicosatrienoic acid analog attenuates angiotensin II hypertension and kidney injury (2014) (12)
Concise synthesis of L-α-phosphatidyl-D-myo-inositol 3,4-bisphosphate, an intracellular second messenger (1997) (12)
Anodic cyclization-rearrangement of methoxybibenzyls to dihydrophenanthrones (1974) (12)
Glomerular Cytochrome P-450 and Cyclooxygenase Metabolites Regulate Efferent Arteriole Resistance (2005) (12)
Total synthesis of the spiro-o-benzoquinonefuran (-)-stypoldione (1993) (12)
A versatile synthesis of 2-haloalk-2(Z)-en-1-ols and 1-chloro-1(Z)-alkenes from trichloromethylcarbinols (2002) (12)
Vascular endothelial overexpression of human CYP2J2 (Tie2-CYP2J2 Tr) modulates cardiac oxylipin profiles and enhances coronary reactive hyperemia in mice (2017) (12)
Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats. (2015) (12)
Development of Robust 17(R),18(S)-Epoxyeicosatetraenoic Acid (17,18-EEQ) Analogs as Potential Clinical Antiarrhythmic Agents. (2019) (12)
Stereospecific Stille Cross-Couplings Using Mn(II)Cl2. (2018) (12)
Contribution of PPARα/β/γ, AP-1, importin-α3, and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock (2016) (12)
Ovariectomy, but not estrogen deficiency, increases CYP4A modulation of alpha(1)-adrenergic vasoconstriction in aging female rats. (2008) (12)
The first preparation of α-functionalized benzylamine (1999) (11)
Metabolism of 12(R)-hydroxyeicosatetraenoic acid by rat liver microsomes. (1992) (11)
Convenient preparation of a-trimethylsilyloxy- and a-hydroxystannanes from aldehydes (1994) (11)
Terpenoid precursors via steroid degradation: synthesis of (–)-warburganal (1987) (11)
Epoxyeicosatrienoic Acid-Based Therapy Attenuates the Progression of Postischemic Heart Failure in Normotensive Sprague-Dawley but Not in Hypertensive Ren-2 Transgenic Rats (2019) (11)
Highly stereoselective synthesis of (Z,E)-1-halo-1,3-dienol esters via rearrangement of Fischer chromium chloro-carbenes using microwave irradiation. (2009) (11)
Uncovering the signalling, structure and function of the 20‐HETE‐GPR75 pairing: Identifying the chemokine CCL5 as a negative regulator of GPR75 (2021) (11)
Role of CYP eicosanoids in the regulation of pharyngeal pumping and food uptake in Caenorhabditis elegans[S] (2015) (11)
Total synthesis of D-myo-inositole 3,4,5-trisphosphate and 1,3,4,5-tetrakisphosphate (1993) (11)
CYP-13A12 of the nematode Caenorhabditis elegans is a PUFA-epoxygenase involved in behavioural response to reoxygenation. (2014) (11)
Reconstitution of LDL with lipophilic fluorescein derivatives: quantitative analysis of the receptor activity of human lymphocytes. (1983) (11)
Synthesis of (±)-hepoxilin A3 utilizing arsonium ylides (1989) (11)
Intracellular second messengers synthesis of L-α-phosphatidyl-D-myo-inositol 3,4-bisphosphate and analogs (1997) (10)
A practical, stereospecific route to 18-, 19-, and 20-hydroxyeicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acids (18-, 19-, and 20-HETEs) (2004) (10)
Total synthesis of (+)-dihydromevinolin (1984) (10)
The Blood Pressure–Lowering Effect of 20-HETE Blockade in Cyp4a14(−/−) Mice Is Associated with Natriuresis (2017) (10)
Oxazoline chemistry. Preparation of isoquinolines and 2,2'-bisoxazolines (1981) (10)
Modulation by Cytochrome P450‐4A ω‐Hydroxylase Enzymes of Adrenergic Vasoconstriction and Response to Reduced PO2 in Mesenteric Resistance Arteries of Dahl Salt‐Sensitive Rats (2010) (10)
CALL FOR PAPERS Regulation of Cardiovascular Functions by Eicosanoids and Other Lipid Mediators Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BKCa channels: implications for soluble epoxide hydrolase inhibition (2006) (10)
Hepoxilins B3: Synthesis of all four stereoisomers and a glutathione adduct (1994) (10)
Involvement of gap junctions between smooth muscle cells in sustained hypoxic pulmonary vasoconstriction development: a potential role for 15-HETE and 20-HETE. (2016) (10)
Synthesis of 14(R),15(S)- and 14(s),15(S)-dihydroxy-5,8-z-10,12-E - eicosatetraenoic acid (1983) (10)
Vascular Endothelial Over-Expression of Human Soluble Epoxide Hydrolase (Tie2-sEH Tr) Attenuates Coronary Reactive Hyperemia in Mice: Role of Oxylipins and ω-Hydroxylases (2017) (10)
Aging Increases Cytochrome P450 4A Modulation of α1-Adrenergic Vasoconstriction in Mesenteric Arteries (2008) (10)
A Biosynthetic Pathway Generating 12-Hydroxy-5,8,14-eicosatrienoic Acid from Arachidonic Acid Is Active in Mouse Skin Microsomes (2006) (10)
20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats (2018) (10)
Enhancement of delayed hypersensitivity inflammatory reactions in guinea pig skin by 12(R)-hydroxy-5,8,14-eicosatrienoic acid. (1995) (10)
A concise synthesis of (R)-hydroxy-E,Z-diene fatty acids: preparation of 12(R)-hete, tetranor-12(R)-hete, and 13(R)-hode (1991) (10)
The arachidonic acid monooxygenase: from biochemical curiosity to physiological/pathophysiological significance (2018) (10)
Enantiospecific synthesis of 17- and 18-hydroxyeicosatetraenoic acids, cytochrome P450 arachidonate metabolites (1992) (10)
A novel synthesis of homologated allylic alcohols using dimethylsulphonium methylide (1994) (10)
5- and 8-HETE production by rat hepatic microsomal cytochrome P-450 (1984) (9)
Metabolism of adrenic acid to vasodilatory 1alpha,1beta-dihomo-epoxyeicosatrienoic acids by bovine coronary arteries. (2007) (9)
Synthesis of bicyclic fused carbocvcles via intramolecular dehydrative alkylation (1995) (9)
Determination of 14,15-epoxyeicosatrienoic acid and 14,15-dihydroxyeicosatrienoic acid by fluoroimmunoassay. (1997) (9)
The Acyl-Homoserine Lactone Synthase YenI from Yersinia enterocolitica Modulates Virulence Gene Expression in Enterohemorrhagic Escherichia coli O157:H7 (2013) (9)
Receptor-mediated delivery of photoprotective agents by low-density lipoprotein. (1984) (9)
Kidney-Targeted Epoxyeicosatrienoic Acid Analog, EET-F01, Reduces Inflammation, Oxidative Stress, and Cisplatin-Induced Nephrotoxicity (2021) (9)
Synthesis of alcohols via mild oxidation of perfluoroethylstannanes (1999) (9)
Altered mechanisms underlying hypoxic dilation of skeletal muscle resistance arteries of hypertensive versus normotensive Dahl rats. (2001) (9)
Total synthesis of 5(S),12(S)- and 5(S),12(R)-dihydroxyeicosa-6(Z),8(E),14(Z)-trienoic acids, metabolites of leukotriene B4 (1989) (9)
A mechanistic study of the chromium(II)-mediated transformations of trichloromethyl alkyls and carbinols: evidence for carbene, carbyne, and carbenoid intermediates (2007) (9)
Effects of hyperbaric oxygenation on vascular reactivity to angiotensin II and angiotensin-(1-7) in rats. (2012) (9)
Three-component synthesis of 2-haloalk-2(Z)-en-1-ols via tandem haloalkylidenation-aldehyde addition (2002) (9)
Tissue protection and endothelial cell signaling by 20-HETE analogs in intact ex vivo lung slices. (2012) (9)
Regio- and Stereoselective Monoepoxidation of Dienes using Methyltrioxorhenium: Synthesis of Allylic Epoxides (2014) (8)
CALL FOR PAPERS Regulation of Cardiovascular Functions by Eicosanoids and Other Lipid Mediators Effects of selective inhibition of cytochrome P-450 -hydroxylases and ischemic preconditioning in myocardial protection (2006) (8)
Direct Preparation of 2‐Deoxy‐D‐glucopyranosides from Glucals without Ferrier Rearrangement. (1991) (8)
Stereoselective synthesis of methyl (Z)-α-methoxyacrylates via two-carbon homologation of aldehydes (2009) (8)
Synthesis and biological evaluation of pyridooxazine-tetrahydroisoquinoline derivatives as MDR modulators (2006) (8)
A Synthetic Epoxydocosapentaenoic Acid Analogue Ameliorates Cardiac Ischemia/Reperfusion Injury: The Involvement of the Sirtuin 3–NLRP3 Pathway (2020) (8)
Combined treatment with epoxyeicosatrienoic acid analog and 20-hydroxyeicosatetraenoic acid antagonist provides substantial hypotensive effect in spontaneously hypertensive rats. (2020) (8)
Synthesis and stereochemical revision of a bioactive dihydroxyeicosanoid isolated from the red marine alga farlowia mollis (1990) (8)
Role of vascular reactive oxygen species in regulating cytochrome P450‐4A enzyme expression in Dahl salt‐sensitive rats (2016) (8)
GPI membrane anchors: Synthesis and functional evaluation of aminoglucosyl phosphatidylinositol core analogs (1996) (8)
Synthesis, structural identification and biological activity of 11,12-dihydroxyeicosatetraenoic acids formed in human platelets. (1991) (8)
Renal 20-HETE inhibition attenuates changes in renal hemodynamics induced by L-NAME treatment in pregnant rats. (2005) (8)
Oligomerization controls in tissue-specific manner ligand binding of native, affinity-purified p42(IP4)/centaurin alpha1 and cytohesins-proteins with high affinity for the messengers D-inositol 1,3,4,5-tetrakisphosphate/phosphatidylinositol 3,4,5-trisphosphate. (2003) (8)
Erratum: Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria (Cell Chemical Biology (2017) 24(10) (1259–1275.e6) (S2451945617302830)(10.1016/j.chembiol.2017.08.009)) (2017) (8)
Enantiospecific synthesis of isomeric8,9,12-trihydroxyeicosa-5(Z),10(E),14(Z)-trienoic acids (1988) (8)
Platelet-neutrophil interactions in the eicosanoid pathway. (1988) (8)
Eicosanoid Metabolism and Bioactivation by Microsomal Cytochrome P450 (1996) (8)
SELECTIVE DELIVERY OF CYTOTOXIC COMPOUNDS TO CELLS BY THE LDL PATHWAY (1985) (8)
Vasodilatory responses of renal interlobular arteries to epoxyeicosatrienoic acids analog are not enhanced in Ren-2 transgenic hypertensive rats: evidence against a role of direct vascular effects of epoxyeicosatrienoic acids in progression of experimental heart failure. (2017) (7)
Synthesis and biological activity of epoxyeicosatrienoic acids (EETs) by cultured bovine coronary artery endothelial cells. (1991) (7)
Efficient total synthesis of 5-oxo-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid (5-oxo-ETE), a potent proinflammatory autacoid (2001) (7)
Mechanisms of activation of eNOS by 20-hydroxyeicosatetraenoic acid and VEGF in bovine pulmonary artery endothelial cells (2006) (7)
The contribution of TRPV1 channel to 20-HETE-Aggravated ischemic neuronal injury. (2018) (7)
One‐Pot Synthesis of Pyridazino[1,4]oxazin‐3‐ones (2004) (7)
Effect of Angiotensin II and ACTH on Adrenal Blood Flow in the Male Rat Adrenal Gland In Vivo (2018) (7)
Interactions between platelets and neutrophils in the eicosanoid pathway. (1989) (7)
Stereospecific Palladium/Copper Cocatalyzed Cross-Coupling of α- Alkoxy- and α-Aminostannanes with Acyl Chlorides. (1994) (7)
Effect of human 15-lipoxygenase-1 metabolites on vascular function in mouse mesenteric arteries and hearts. (2013) (7)
Mechanisms of Carbon Monoxide Attenuation of Tubuloglomerular Feedback (2012) (7)
Acylation of Glucosaminyl Phosphatidylinositol Revisited PALMITOYL-CoA DEPENDENT PALMITOYLATION OF THE INOSITOL RESIDUE OF A SYNTHETIC DIOCTANOYL GLUCOSAMINYL PHOSPHATIDYLINOSITOL BY HAMSTER MEMBRANES PERMITS EFFICIENT MANNOSYLATION OF THE GLUCOSAMINE RESIDUE* (1996) (7)
Studies towards asymmetric synthesis of 4(S)-11-dihydroxydocosahexaenoic acid (diHDHA) featuring cross-coupling of chiral stannane under mild conditions. (2015) (7)
Efficient N-arylation of pyridazin-3(2H)-ones (2004) (7)
Cytochrome P-450 Epoxygenase Dependent Formation of Novel Endogenous Epoxyeicosatrienoyl-Phospholipids (1993) (7)
Preparation of O-Alkylhydroxamic Acids Using 2-Acylpyridazin-3(2H)-ones in Water (2004) (7)
Effects of Epoxyeicosatrienoic Acid-Enhancing Therapy on the Course of Congestive Heart Failure in Angiotensin II-Dependent Rat Hypertension: From mRNA Analysis towards Functional In Vivo Evaluation (2021) (6)
Mitogenic Activity and Signaling Mechanism of 2-(14,15-Epoxyeicosatrienoyl)Glycerol, a Novel Cytochrome P450 Arachidonate Metabolite (2007) (6)
Reduced coronary reactive hyperemia in mice was reversed by the soluble epoxide hydrolase inhibitor (t-AUCB): Role of adenosine A2A receptor and plasma oxylipins. (2017) (6)
Stereospecific Suzuki Cross-Coupling of Alkyl α-Cyanohydrin Triflates. (2010) (6)
Synthesis of Two Intermediate Phosphonium Salts for 5,20 and 15,20-DiHetes (1989) (6)
Generation of Nucleophilic Chromium Acetylides from gem-Trichloroalkanes and Chromium Chloride: Synthesis of Propargyl Alcohols. (2010) (6)
Human U 251 Glioma Cell Proliferation Is Suppressed by HET 0016 [ N-Hydroxy-N-( 4-butyl-2-methylphenyl ) formamidine ] , a Selective Inhibitor of CYP 4 A (2005) (6)
20-HETE Participates in Intracerebral Hemorrhage-Induced Acute Injury by Promoting Cell Ferroptosis (2021) (6)
Inhibition of renin secretion from rat renal cortical slices by (R)-12-HETE. (1992) (6)
Pharmacological manipulation of arachidonic acid-epoxygenase results in divergent effects on renal damage (2014) (6)
Methyl Carboxymethylenation of Alcohols via Dehydrative Alkylation (1995) (6)
Involvement of arachidonic acid metabolites in the control of hypothalamic-pituitary function. (1985) (6)
Cascade synthesis of (E)-2-alkylidenecyclobutanols. (2009) (6)
Oxidative decarboxylation of mandelate ethers and α-substituted phenylacetates via dioxetanone generation (1992) (6)
Transition Metal-Free ipso-Functionalization of Arylboronic Acids and Derivatives (2014) (6)
5E, 8Z, 11Z, 14Z-eicosatetraenoic acid, a novel trans isomer of arachidonic acid, causes G1 phase arrest and induces apoptosis of HL-60 cells. (2005) (6)
Cu(OTf)2-Catalyzed Beckmann Rearrangement of Ketones Using Hydroxylamine-O-sulfonic Acid (HOSA) (2019) (6)
Stereochemical analysis and biological activity of 3-hydroxy-leukotriene B4: a metabolite from ethanol-treated rat hepatocytes. (1994) (6)
Cell‐Cell Interactions in the Eicosanoid Pathway a (1987) (6)
Interlobular Arteries From 2‐Kidney, 1‐Clip Goldblatt Hypertensive Rats’ Exhibit‐Impaired Vasodilator Response to Epoxyeicosatrienoic Acids (2016) (6)
19-Hydroxyeicosatetraenoic acid analogs: Antagonism of 20-hydroxyeicosatetraenoic acid-induced vascular sensitization and hypertension. (2019) (6)
Molecular basis for the omega-regiospecificity of the CYP4A2 and CYP4A3 fatty acid hydroxylases. (2000) (6)
An efficient iron catalyzed regioselective acylative cleavage of ethers: Scope and mechanism (2015) (6)
Reactivity of α-mesyloxystannanes with organocopper reagents : preparation of chiral stannanes (1993) (6)
Failure to upregulate the adenosine 2 A receptor-epoxyeicosatrienoic acid pathway contributes to the development of hypertension in Dahl salt-sensitive rats (2008) (6)
Convenient preparation of (Z)-α-halo-α,β-unsaturated aldehydes: synthesis of a Laurencia flexilis toxin (2008) (6)
Ion transport inhibition in the medullary thick ascending limb of Henle's loop by cytochrome P450-arachidonic acid metabolites. (1991) (6)
Tin‐Copper Transmetalation: Cross‐Coupling of α‐Heteroatom‐ Substituted Alkyltributylstannanes with Organohalides. (1995) (5)
CONTROLLED CHEMICAL SYNTHESIS OF THE ENZYMICALLY PRODUCED EICOSANOIDS 11-, 12-, AND 15-HETE FROM ARACHIDONIC ACID AND CONVERSION INTO THE CORRESPONDING HYDROPEROXIDES (HPETE) (1980) (5)
Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z), 11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity. (2003) (5)
Role of CYP epoxygenases in A 2 AAR-mediated relaxation using A 2 AAR-null and wild-type mice (2008) (5)
, John and Pulmonary Vascular Remodeling Cytochrome P 450 Epoxygenase Gene Function in Hypoxic Pulmonary Vasoconstriction (2006) (5)
20-HETE pathway antagonists inhibit rat small mesenteric artery tone. (2002) (5)
A soluble epoxide hydrolase inhibitor--8-HUDE increases pulmonary vasoconstriction through inhibition of K(ATP) channels. (2012) (5)
Early Renal Vasodilator and Hypotensive Action of Epoxyeicosatrienoic Acid Analog (EET-A) and 20-HETE Receptor Blocker (AAA) in Spontaneously Hypertensive Rats (2021) (5)
Suzuki—Miyaura Cross‐Coupling of Lithium n‐Alkylborates. (2001) (5)
Vasoactive eicosanoids: Synthesis of 12,20-dihydroxyeicosa-5(Z),8(Z),10(E),14(Z)-tetraenoic acid via a novel chiral bis-lactol (1994) (5)
Deactivation of 12(S)-HETE through (ω-1)-hydroxylation and β-oxidation in alternatively activated macrophages[S] (2018) (5)
Vitamin C activation of the biosynthesis of epoxyeicosatrienoic acids. (2012) (5)
Enantiospecific Total Synthesis of a Novel Arachidonic Acid Metabolite 3-Hydroxyeicosatetraenoic Acid. (1998) (5)
TOTAL SYNTHESIS OF ERYTHROMYCINS. 4. TOTAL SYNTHESIS OF ERYTHRONOLIDE B (1978) (5)
Evaluation of cytochrome P450-4A omega-hydroxylase and 20-hydroxyeicosatetraenoic acid as an O2 sensing mechanism in the microcirculation. (2004) (5)
A tagging-via-substrate technology for genome-wide detection and identification of farnesylated proteins. (2006) (4)
Practical, Enantiospecific Syntheses of 14,15-EET and Leukotoxin B (Vernolic Acid). (2002) (4)
CYP450 4A inhibition attenuates O2 induced arteriolar constriction in chronic but not acute Goldblatt hypertension. (2009) (4)
The Cytochrome P450 Inhibitor Ketoconazole Potentiates 5-Hydroxytryptamine-Induced Contraction in Rat Aorta (2007) (4)
Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles. (2011) (4)
Absence of adenosine–induced relaxation in A2A adenosine receptor‐KO mouse aorta: role of CYP 2C9 and CYP 4A (2007) (4)
(Z)‐α‐Haloacrylates: An Exceptionally Stereoselective Preparation via Cr(II)‐Mediated Olefination of Aldehydes with Trihaloacetates. (2003) (4)
8,9‐EPOXYARACHIDONIC ACID: A CYTOCHROME P‐450 METABOLITE (1982) (4)
Erratum: Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome P450 arachidonate metabolite (Molecular and Cellular Biology (2007) 27, 8, (3023-3034)) (2007) (4)
Development of a Primary Human Co-Culture Model of Inflamed Airway Mucosa (2017) (4)
Reactivity of γ-chloro- gem -trichloroalkanes with chromous chloride (2006) (4)
Inhibition of NLRP3 inflammasome contributes to protective effect of 5,14-HEDGE against lipopolysaccharide-induced septic shock (2017) (4)
Stereospecific Cross-Coupling of α-(Thiocarbamoyl)organostannanes with Alkenyl, Aryl, and Heteroaryl Iodides [J. Am. Chem. Soc. 2007, 129, 790−793]. (2007) (4)
Total Synthesis of the Spiro‐o‐benzoquinonefuran (‐)‐Stypoldione. (1994) (4)
Terpenoid chirons: Preparation and transformations of 2-hydroxy-1,1,4a(R),6-tetramethyl-trans-Δ5,6-octalin (1994) (4)
20-HETE Activates the Transcription of Angiotensin Converting Enzyme (ACE) via NF-kB Translocation and Promoter Binding (2015) (4)
ARACHIDONATE EPOXYGENASE: INHIBITORS AND METABOLITE ANALOGS (1985) (4)
20-HETE MEDIATES ENDOTHELIAL DYSFUNCTION VIA IKK-DEPENDENT (2009) (4)
20-HETE agonists and antagonists in the renal circulation. (1999) (3)
The Cytochrome P 450 4 A / F-20-Hydroxyeicosatetraenoic Acid System : A Regulator of Endothelial Precursor Cells Derived from Human Umbilical Cord Blood (2011) (3)
Total synthesis of 5(S),20- and 15(S),20-dihydroxyeicosatetraenoic acid and 5(S),6(R)-epoxy-20-hydroxy- and 14(R),15(S)-epoxy-20-hydroxyeicosatreinoic acid (1987) (3)
Total Synthesis of Vineomycinone B2 Methyl Ester via Double Bradsher Cyclization. (1991) (3)
Abstract LB-160: CYP4F isoform expression and 20-HETE synthesis in prostate cancer cells are regulated by androgen and contribute to growth (2012) (3)
Macrophage 12(S)-HETE Enhances Angiotensin II–Induced Contraction by a BLT2 (Leukotriene B4 Type-2 Receptor) and TP (Thromboxane Receptor)-Mediated Mechanism in Murine Arteries (2021) (3)
Perkin communications. Heterocyclic [4++ 2] cycloadditions: the reactivity of pyridinium salts with electron-rich olefins (1990) (3)
N-Acylsulfonamide Assisted Tandem C—H Olefination/Annulation: Synthesis of Isoindolinones. (2011) (3)
2-Cyanopyridazin-3(2H)-ones: Effective and Chemoselective Electrophilic Cyanating Agents. (2005) (3)
Increased production of 20‐HETE contributes to the effects of COX inhibitors to prevent the decrease in lipid peroxidation and increase in catalase activity during endotoxemia (2009) (3)
14, 15-cis-episulfide-eicosatrienoic acid, an 'epoxygenase' eicosanoid analog, inhibits ionophore- but not thrombin-induced platelet aggregation. (1991) (3)
20‐SOLA, a Novel Water Soluble 20‐HETE Antagonist, Reduces Blood Pressure Through Regulation of Vascular ACE Expression via an IKK Dependent Pathway (2015) (3)
Development of enzyme immunoassays for 5,6-, 8,9-, 11,12-, and 14,15- EETs and the corresponding DHETs. (2002) (3)
Blockade of 20-hydroxyeicosatetraenoic acid receptor lowers blood pressure and alters vascular function in mice with smooth muscle-specific overexpression of CYP4A12-20-HETE synthase (2022) (3)
Ether epoxyeicosatrienoic acid (EET) analogs lower blood pressure when administered in‐vivo to the spontaneously hypertensive rats (2008) (3)
Chiral α,β‐Dialkoxy‐ and α‐Alkoxy‐β‐aminostannanes: Preparation and Copper‐Mediated Cross‐Coupling. (2004) (3)
vic-Diol chirons: Enantiospecific synthesis of 11,12- and 14,15-dihydroxyeicosatrienoic acids (1994) (3)
Stereocontrolled Synthesis of α‐Amino‐α′‐alkoxy Ketones by a Copper‐Catalyzed Cross‐Coupling of Peptidic Thiol Esters and α‐Alkoxyalkylstannanes. (2011) (3)
Enantiomeric Separations of N–H/N–Me Aziridines Utilizing GC and HPLC (2014) (3)
One-Pot Synthesis of Symmetrical 1,4-Disubstituted Piperazine-2,5-diones. (2004) (2)
Microwave-Assisted One-Pot Synthesis of Benzo[b][1,4]thiazin-3(4H)-ones via Smiles Rearrangement. (2009) (2)
Flow Dilation in Rat Small Mesenteric Arteries is Mediated by Hydrogen Peroxide Generated from CYP Epoxygenases and Xanthine Oxidase (2009) (2)
The protective effect of astrocyte-derived 14,15-EET on H2O2- induced cell injury in Astrocyte-dopaminergic neuronal cell line co-culture (2014) (2)
Synthesis of Enantioenriched α‐(Hydroxyalkyl)‐tri‐n‐butylstannanes. (2008) (2)
Activation of GPR75 Signaling Pathway Contributes to the Effect of a 20-HETE Mimetic, 5,14-HEDGE, to Prevent Hypotensive and Tachycardic Responses to Lipopolysaccharide in a Rat Model of Septic Shock (2022) (2)
Regulation of Vascular Tone During Pregnancy (2007) (2)
Insulin Second Messengers: Synthesis of 6‐O‐(2‐Amino‐2‐deoxy‐α‐D‐ glucopyranosyl)‐D‐chiro‐inositol‐1‐phosphate. (1994) (2)
Novel Orally Active Epoxyeicosatrienoic Acid (EET) Analogs Attenuate Cisplatin Nephrotoxicity (2012) (2)
Enantiospecific Synthesis of Inositol Polyphosphates, Phosphatidylinositides, and Analogues from (‐)‐Quinic Acid (1992) (2)
Erratum: Modulation of V1-receptor-mediated renal vasoconstriction by epoxyeicosatrienoic acids (American Journal of Physiology - Regulatory Integrative and Comparative Physiology (July 2004) 56 (R181-R187)) (2004) (2)
Novel Synthetic Analogues of 19(S/R)-Hydroxyeicosatetraenoic Acid Exhibit Noncompetitive Inhibitory Effect on the Activity of Cytochrome P450 1A1 and 1B1 (2021) (2)
Expression of epoxygenases belonging to CYP2 family in rat myocardial ischemia/reperfusion injury in vivo. (2008) (2)
Synthetic Studies on Isoquinoline Derivatives with Multidrug Resistance (MDR) Modulating Activity. (2004) (2)
Angiogenic factors: syntheses of 12(R)- and 12(S)-hydroxyeicosa-5(Z),8(Z),14(Z)-trienoic acid and their 14,15-dehydro analogs (1994) (2)
Facile Reduction of Carboxylic Acids, Esters, Acid Chlorides, Amides and Nitriles to Alcohols or Amines Using NaBH4/BF3×Et2O. (2004) (2)
EET Analog Treatment Improves Insulin Signaling in a Genetic Mouse Model of Insulin Resistance. (2021) (2)
Arachidonate Epoxygenase: Total Synthesis of Both Enantiomers of 8,9and 11,12-Epoxyeicosatrienoic Acid. (1987) (2)
Preparation of (Z)-1-halo-1-alkenes and (Z)-1-halo-2-alkoxy-1-alkenes using Cr(II/III) and Fe(0) (2006) (2)
Correction to 14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) Surrogates: Carboxylate Modifications (2014) (2)
Synthesis of 12(S),20-, 12(S),19(R)-, and 12(S),19(S)-Dihydroxyeicosa-cis-5,8,14-trans-10-tetraenoic Acids, Metabolites of 12(S)-HETE. (1986) (2)
A concise synthesis of 12(S), 20-dihydroxyeicosa-5(Z), 8(Z), 10(E), 14(Z)-tetraenoic acid, an endogenous vasoconstrictor (2004) (2)
A Synthesis of L‐α‐Phosphatidyl‐D‐myo‐inositol 4,5‐Bisphosphate (4,5‐PIP2) and Glyceryl Lipid Analogues. (2000) (2)
A Highly Stereospecific Synthesis of (E)‐α,β‐Unsaturated Esters. (2004) (1)
Rhodium‐Catalyzed Annulation of N‐Benzoylsulfonamide with Isocyanide Through C—H Activation. (2012) (1)
Rhodium(I)-Catalyzed N—CN Bond Cleavage: Intramolecular β-Cyanation of Styrenes. (2013) (1)
Eicosanoids are Activators of Peroxisome Proliferator-Activated Receptor (2007) (1)
Epoxyeicosatrienoic Acid Analog and 20-HETE Antagonist Combination Prevent Hypertension Development in Spontaneously Hypertensive Rats (2022) (1)
contractile tension of the lamb ductus arteriosus Further evidence implicating a cytochrome P-450-mediated reaction in the (2011) (1)
Abstract 047: 20-SOLA, A Novel Water-soluble 20-HETE Antagonist, Elicits Natriuresis And Abrogates Hypertension In Cyp4a14 Knockout Mice. (2014) (1)
New Group of Lipid Mediators Containing ω-Hydroxyarachadonic Acid (20-HETE) (1997) (1)
Enantiospecific Total Synthesis of 8- and 12-Hydroxyeicosatetraenoic Acid. (1987) (1)
2-Chloropyridazin-3(2H)-ones as Electrophilic Chlorinating Agents: Effective α-Chlorination of Active Methylene/Methine Compounds (2005) (1)
Convenient syntheses of [20,20,20-H(3)]-arachidonic acid and [20,20-H(2)]-20-hydroxyeicosatetraenoic acid. (2006) (1)
AN INTRAMOLECULAR PASSERINI REACTION: SYNTHESIS OF HYDRASTINE (1981) (1)
A Convenient Preparation of Alkyl Halides and Cyanides from Alcohols by Modification of the Mitsunobu Procedure. (1986) (1)
2‐Chloropyridazin‐3(2H)‐ones as Electrophilic Chlorinating Agents: Effective α‐Chlorination of Active Methylene/Methine Compounds. (2005) (1)
Abstract 36: Deficiency in the Production of 20-HETE Contributes to Impaired Myogenic and TGF Responses in the Afferent Arteriole of Dahl S Rats (2012) (1)
Kinetic proﬁle of the rat CYP4A isoforms: arachidonic acid metabolism and isoform-speciﬁc inhibitors (1999) (1)
ischemia-reperfusion injury in vivo Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial (2008) (1)
Taxol Total Synthesis: Preparation of a Chiral Ring A Moiety via Biomimetic Cyclization and Evaluation of a Tandem Nitrile Oxide Strategy for Rings B/C. (1996) (1)
Novel epoxyeicosatrienoic acid analog ameliorates renal injury in a rat model of radiation nephropathy (690.7) (2014) (1)
Chemical syntheses of trioxilins. (1990) (1)
Directed, Remote Dirhodium C(sp3)-H Functionalization, Desaturative Annulation, and Desaturation. (2022) (1)
Total Synthesis of (.+-.)-Halomon by a Johnson—Claisen Rearrangement. (1998) (1)
Synthesis of (.+-.)-Hepoxilin A3 Utilizing Arsonium Ylides. (1989) (1)
Structural determinants of the renal vascular response to 20-hydroxyeicosatetraenoic acid (20-HETE) (1997) (1)
Inhibits Endothelium-Dependent Hyperpolarization and Relaxation in Coronary Arteries )-enoic Acid : A Selective Epoxyeicosatrienoic Acid Antagonist (2002) (1)
Alternative Pathways for Heck Intermediates: Pd-catalyzed Oxy- arylation of Homoallylic Alcohols** (2012) (1)
Preparation and Scope of a Remarkably Robust Primary Alcohol Protective Group. (1995) (1)
20‐HETE Interferes with Insulin Signaling Through GPR75 (2019) (1)
Grignard Additions to α,β‐Unsaturated Dioxolanones: Preparation of Chiral Allylic Alcohols and Protected α‐Hydroxy Aldehydes. (1996) (1)
Site-selective amination and/or nitrilation via metal-free C(sp2)–C(sp3) cleavage of benzylic and allylic alcohols (2022) (1)
Abstract 15620: 20-HETE-mediated Neutrophil Adhesion Impairs Coronary Collateral Growth in Metabolic Syndrome (2016) (1)
Overexpression of CYP4A1‐20‐HETE in U251 Glioma Cell Induces Hyperproliferative Phenotypes in vitro and in vivo (2008) (1)
Upregulation of 20-HETE Synthetic Cytochrome P450 Isoforms by Oxygen–Glucose Deprivation in Cortical Neurons (2017) (1)
novel localization in vascular endothelium CYP4A mRNA, protein, and product in rat lungs: (2015) (1)
Novel eicosanoids generated by cytochrome P450: effects on platelet aggregation and protein phosphorylation. (1990) (1)
Correction: Studies towards asymmetric synthesis of 4(S)-11-dihydroxydocosahexaenoic acid (diHDHA) featuring cross-coupling of chiral stannane under mild conditions. (2015) (1)
Novel Synthesis of Pyridazino[4,5-b][1,4]oxazin-3,8-diones. (2004) (1)
Errautm: Studies towards asymmetric synthesis of 4(S)-11-dihydroxydocosahexaenoic acid (diHDHA) featuring cross-coupling of chiral stannane under mild conditions(Organic and Biomolecular Chemistry (2015) DOI: 10.1039/c4ob02324b.) (2015) (1)
Protection of mouse pulmonary arteries from hypoxia‐induced apoptosis: Cross talk between phosphoinositide 3‐kinase (PI3K) and ATP‐sensitive potassium (KATP) channels (2008) (1)
Modulation of aortic reactivity to angiotensin-(1-7) with intermittent hyperbaric oxygenation in diabetic rats (2012) (1)
Integrative Physiology 20-HETE Signals Through G-Protein–Coupled Receptor GPR75 (G q ) to Affect Vascular Function and Trigger Hypertension (2017) (1)
Heart Failure : Novel Therapeutic Pathways Emerging from Basic Science EET intervention on Wnt 1 , NOV , and HO-1 signaling prevents obesity-induced cardiomyopathy in obese mice (2017) (1)
Role of CYP2C generated metabolites in adenosine‐mediated relaxation using A2A AR−/− mice (2008) (1)
EDHF-like responses in rat cremaster muscle arterioles (2005) (1)
Enantioselective, organocatalytic oxy-michael addition to gamma/delta-hydroxy-alpha,beta-enones: boronate-amine complexes as chiral hydroxide synthons. (2008) (1)
Synthesis of Alcohols via Mild Oxidation of Perfluoroethylstannanes. (1999) (1)
Enhanced vascular relaxation through epoxygenase depends on ATP‐sensitive K+ channels via adenosine A2A receptor: Role of high salt diet (2009) (1)
Development of immunoassays for 5,6-, 8,9- 11,12-, and 14-15 epoxyeicosatrienoic acids (EETs) and corresponding dihydroxyeicosatrienoic acids (DHETs) (1999) (1)
Convenient Preparation of (Z)‐α‐Halo‐α,β‐unsaturated Aldehydes: Synthesis of a Laurencia flexilis Toxin. (2008) (1)
Rhodium Catalyzed C—H Olefination of N-Benzoylsulfonamides with Internal Alkenes. (2012) (1)
Intramolecular N-Me and N-H aminoetherification for the synthesis of N-unprotected 3-amino-O-heterocycles. (2021) (1)
Role of CYP-epoxygenases in A2A adenosine receptor-mediated relaxation using A2AAR-null and wild-type mice (2008) (1)
Exaggerated vasoconstriction depends on ω‐hydroxyylase through adenosine A1receptor (AR) in A1 WT compared to A1 KO mouse aorta (2010) (1)
Molecular characterization of a renal cytochrome p450 epoxygenase responsive to animal sodium chloride loading (1992) (1)
Novel Contributions of Neutrophil‐derived Myeloperoxidase and Hypochlorous Acid to 20‐HETE Production that drives Post‐Ischemic Angiogenesis (2020) (1)
Endothelial NO Synthase Knockout Mice Contribution of 20-HETE to Augmented Myogenic Constriction in Coronary Arteries of (2005) (1)
The cytochrome P450-dependent metabolism of arachidonic acid (1984) (1)
Epoxyeicosatrienoic acids act as second messengers in VEGF-induced angiogenesis (2006) (1)
SYNTHESIS OF 14(R),15(S)- AND 14(S),15(S)-DIHYDROXY-5,8-Z-10,12-E-EICOSATETRAENOIC ACID (1984) (0)
20‐Hydroxyeicosatetraenoic acid protects the pulmonary vasculature from apoptosis (2008) (0)
Intra‐Abdominal Lipectomy Reduces Large Arterial Stiffness and Blood Pressure in Metabolic Syndrome (2018) (0)
CYP-13A12 of the nematode C. elegans is a PUFA-epoxygenase involved in behavioural response to reoxygenation. (2014) (0)
Contribution of 20-HETE to the vasodilator actions of nitric oxide in renal arteries. (1998) (0)
A Convenient Synthesis of (Z)-1-Chloro-1-alkenes and (Z)-1-Chloro-2-alkoxy-1-alkenes. (2002) (0)
6883 Parametric Mapping of Renal T 2 * Demonstrates Beneficial Effect of Epoxyeicosatrienoic Acid for Preventing Acute Kidney Injury (2013) (0)
Abstract 517: The CYP4A-20-HETE System Regulation of Endothelial Progenitor Cell Functions that Associated with Angiogenesis (2012) (0)
MEVINIC ACIDS AND ANALOGS: PREPARATION OF A KEY CHIRAL INTERMEDIATE (1983) (0)
3(S)-hydroxy-leukotriene B4 is a potent granulocyte chemotaxin in the guinea pig dermis (1995) (0)
Concise Syntheses of L‐α‐phosphatidyl‐D‐myo‐inositol 3‐Phosphate (3‐PIP), 5‐Phosphate (5‐PIP), and 3,5‐Bisphosphate (3,5‐PIP2). (2000) (0)
An Efficient Iron Catalyzed Regioselective Acylative Cleavage of Ethers: Scope and Mechanism. (2016) (0)
20‐HETE Antagonism Reduces Left Ventricular Remodeling Post‐Myocardial Infarction (2019) (0)
Stereospecific α-Alkoxystannane Couplings with Acyl Chlorides: Total Synthesis of (+)-Goniofufurone. (1994) (0)
OR-56: Cytochrome P450 products of arachidonate contribute to the differential control of renal cortical and medullary perfusion (2003) (0)
α-Chlorovinylation: Synthesis of 2-Chloropropenyl and Propargyl Alcohols. (2010) (0)
Abstract 16481: A Novel Synthetic Omega-3 Epoxyeicosanoid Analogue Modulates Ca2+ Handling and Exerts Anti-Arrhythmic Effects (2017) (0)
Vinyl Sulfides from Thioacetals with Copper(I) Trifluoromethanesulfonate: (Z)‐2‐Methoxy‐1‐Phenylthio‐1,3‐Butadiene (2003) (0)
Chiral Cyclopropanes: Asymmetric Synthesis of Constanolactones A and B. (2002) (0)
Erratum (2014) (0)
Preparation of L-alpha-phosphatidyl-D-myo-inositol 3-phosphate (3-PIP) and 3,5-bisphosphate (3,5-PIP2). (2000) (0)
Regio- and Enantioselective Catalytic Monoepoxidation of Conjugated Dienes: Synthesis of Chiral Allylic cis-Epoxides. (2015) (0)
Enantiospecific Synthesis of Isomeric 8,9,12-Trihydroxyeicosa-5Z,10E,14Z-trienoic Acids. (1989) (0)
Role of 20‐HETE in Differential Effects of High Salt Diet on Resistance Artery Function in Dahl Salt‐Sensitive (SS) Rats and SS‐5BN Consomic Rats (2010) (0)
Epoxyeicosatrienoic acids (EETs) block cardiomyocyte cell death from hypoxia/reoxygenation injury via the PI3K/Akt survival pathway (2007) (0)
Abstract 202: Activation of Cyp4a12-20-HETE Synthase Increases Blood Pressure and Promotes Vascular Hypertrophy and Cardiac Dysfunction (2013) (0)
JEPT #59626 1 Catalytic Activity and Isoform Specific Inhibition of Rat CYP4F Enzymes (2003) (0)
A Novel Synthesis of Homologated Allylic Alcohols Using Dimethylsulfonium Methylide. (1994) (0)
C-Glycosides: Pd/Cu Co-catalyzed Thiocarboxylation of Stannyl Glucopyranosides. (1995) (0)
Dimethylarginine in Angiotensin II-Infused Rats : Effects of Tempol Impaired Endothelial Function and Microvascular Asymmetrical (2010) (0)
Palladium-Catalyzed Cross-Coupling and Tandem Cyclization-Coupling of . alpha.-Halo(thio)ethers with Organotins. (1993) (0)
Direct Stereospecific Synthesis of Unprotected N—H and N—Me (XII) Aziridines from Olefins. (2014) (0)
Capdevila, J., G.D. Snyder and J.R. Falck, Epoxygenation of arachidonic acid by rat anterior pituitary microsomal fractions (1984) FEBS Letters 178, 319‐322 (2001) (0)
Tang, X.‐S. and K. Satoh, The oxygen‐evolving photosystem II core complex (1985) FEBS Letters 179, 60‐64 (2001) (0)
Inhibition of CYP4A decreases 9L gliosarcoma cell proliferation and brain tumor volume in rats (2005) (0)
Synthesis of Curacin A, an Antimitotic Cyclopropane‐Thiazoline from the Marine Cyanobacterium Lyngbya mjuscula. (1997) (0)
Rhodium Catalyzed Annulation of N -Benzoylsulfonamide with Isocyanide via C-H Activation (2012) (0)
Abstract 438: Regulation of Ischemia-induced Neovascularization by 20-HETE Involves Bone Marrow-derived EPC. (2015) (0)
Neutrophil-Derived Myeloperoxidase and Hypochlorous Acid Critically Contribute to 20-Hydroxyeicosatetraenoic Acid Increases that Drive Postischemic Angiogenesis (2022) (0)
Modeling the 20‐HETE Binding Site on GPR75 (2019) (0)
Abstract 16580: A Novel Synthetic Omega-3 Epoxyeicosanoid Analogue Mediates Cardioprotection by Modulating Mitochondrial Function (2017) (0)
Interaction of nitric oxide and 20‐HETE during cortical functional hyperemia (2006) (0)
Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKKβ/IκB-α/NF-κB pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock (2014) (0)
Synthesis of hydroxyeicosatetraenoic acids (HETE's) by adrenal glomerulosa cells and incorporation into cellular lipids (1986) (0)
Oxidative Decarboxylation of Mandelate Ethers and α‐Substituted Phenylacetates via Dioxetanone Generation. (1993) (0)
Alkylthioether Synthesis via Imidazole-Mediated Mitsunobu Condensation. (1999) (0)
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and synthetic 1,5-(PP)2-IP4 (1,5-IP8) (2011) (0)
Isomerization of Epoxides to Allylic Alcohols Using Methylmagnesium N-Cyclohexylisopropylamide. (1986) (0)
AFLUID November 46/5 (1999) (0)
ROMK1-phosphoinositide interaction Structural determinants and specificities for (2016) (0)
Agonists and antagonists of 20-HETE. (1999) (0)
Synthesis of 12(R),13(S)-Oxido-9Z-octadecenoic (Vernolic) and 13(S)- Hydroxy- 9Z,11E-octadecadienoic (Coriolic) Acids. (1986) (0)
The ‘EDHF’ Antagonist 14, 15 Epoxyeicosa-5(Z)-Enoic Acid has Vasodilator Properties in Mesenteric Vessels (2004) (0)
Homocoupling of Alkyl-, Alkenyl-, and Arylboronic Acids. (2003) (0)
Cu2S‐Mediated Cross‐Coupling of α‐Stannylepoxides. (1997) (0)
Abstract 2279: The response of breast cancer cell lines to HET0016 alone or in combination with other chemotherapeutics (2011) (0)
The arachidonic acid epoxygenase: A functional role for cytochrome P450 in the biosynthesis of novel lipid derived mediators (1992) (0)
One-Pot Synthesis of Pyridazino[1,4]oxazin-3-ones (2004) (0)
Salt induced vascular response through adenosine A2A receptor: role of CYP epoxygenase and soluble epoxide hydrolase (2010) (0)
RAT MESENTERIC ARTERY FUNCTION AFTER HINDLIMB SUSPENSION (2001) (0)
Reactivity of γ-Chloro-gem-trichloroalkanes with Chromous Chloride. (2006) (0)
Abstract 342: Vascular Endothelial Ace Deletion Or AT1R Blockade Reduces Blood Pressure But Does Not Prevent Vascular Remodeling In Models Of 20-HETE-Dependent Hypertension (2014) (0)
A Preparation of Benzylic and Allylic Boronates: Cross-Coupling of Aryl- and Alkenylstannanes with Bromomethylboronates. (1999) (0)
Salt modulates vascular response in eNOS‐null mice through adenosine A2A receptor: role of CYP450 epoxygenase and soluble epoxide hydrolase (2010) (0)
Abstract 122: 20-HETE Antagonists Normalize Large Artery Stiffness and Systolic Blood Pressure in Metabolic Syndrome (2017) (0)
Role of CYP4A/20‐HETE Pathway in Vascular Oxidative Stress in the Dahl Salt‐Sensitive Rat (2012) (0)
Abstract P426: Suppression of Intrarenal Ras With a 20-hydroxyeicosatetraenoic Acid Antagonist Attenuates Ang II-dependent Malignant Hypertension and Reverses Established Ang-II-dependent Hypertension in Cyp1a1-ren-2 Transgenic Rats (2017) (0)
Hydroxyeicosatetraenoic acid analogs and methods for use in the treatment of dry eye disorders. (2000) (0)
Chromium Vinylidene Carbenoids: Stereospecific Synthesis of (Z)‐2‐Chloroalk‐2‐en‐1‐ols. (2002) (0)
Homologation of Aldehydes Using (Phenylthiomethylene)triphenylarsorane. (1990) (0)
Chips : 98 % Sensitivity and Specificity (2016) (0)
A Versatile Synthesis of 2-Haloalk-2(Z)-en-1-ols and 1-Chloro-1(Z)-alkenes from Trichloromethylcarbinols. (2002) (0)
Vasoconstriction and Pulmonary Vascular Remodeling Cytochrome P450 Epoxygenase Gene Function in Hypoxic Pulmonary (2006) (0)
Total Synthesis of the Ethanol-Inducible, Proinflammatory Autacoid 3(S) -Hydroxy-Leukotriene B4 (3-OH-LTB4) and Analogues. (1994) (0)
Introduction. P450 metabolites of arachidonic acid--from biochemistry to therapy. (2013) (0)
20‐HETE Activates Endothelial ACE via an IKK/NF‐kB Dependent Pathway (2013) (0)
ATP‐induced local and conducted vasomotor mechanisms in isolated rat cerebral penetrating arterioles (2006) (0)
URINARY 20-HYDROXYEICOSATETRAENOICACID IS ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION IN HUMANS: OP 072 (2004) (0)
Hydroxyeicosatetraensäureanaloge method and their use for the treatment of dry eye (2000) (0)
Sulfur Ylide Vinylation of Halides and Mesylates. (1994) (0)
Chromium in Organic Synthesis. From Methodology to Total Synthesis of Natural Products (2010) (0)
CYP 4 and 20‐HETE enhance NADPH oxidase and ROS production in pulmonary artery endothelial cells (2007) (0)
Abstract 159: Inhibition of Ace Does Not Prevent 20-hete-mediated Vascular Injury in Cyp4a12tg Mice (2013) (0)
Jessica astrocytes signaling in perivascular + in glutamate-mediated K Role of epoxyeicosatrienoic acids as autocrine metabolites (2014) (0)
Regioselectivity of Pictet—Spengler Cyclization: Synthesis of Halotetrahydroisoquinolines. (2001) (0)
Ruthenium Catalyzed Oxidative Annulation with Alkynes via Cascade C—H/N—H Bond Functionalizations. (2014) (0)
Abstract 338: 20-HETE Contributes To Ischemia-induced Compensatory Neovascularization (2014) (0)
2-Chloropyridazin-3(2H)-ones as Electrophilic Chlorinating Agents: Effective a-Chlorination of Active Methylene/Methine Compounds Electrophilic Chlorination with 2-Chloropyradizin-3(2H)-ones (2005) (0)
Abstract 73: Selective Inhibition of COX-1 & 2 Results in Reprogramming of Adipocyte Gene Expression and Adipogenesis in Mesenchymal Stem Cells: Role of 20-HETE-derived 20-OH-PGE2 (2012) (0)
Conjugate Addition of α‐Alkoxystannanes via in situ Transmetalation Using Catalytic CuCN. (1996) (0)
Treatment of Hypertension with Stable Analogue of 14, 15‐Epoxyeicosatrienoic Acid (EET‐A) in Spontaneously Hypertensive Rats (2019) (0)
CYP-Derived metabolites of Omega-3 fatty acids protect your heart (2022) (0)
Total Synthesis of the 5‐Methylenephosphonate Analogue of D‐myo‐ Inositol 1,4,5‐Trisphosphate. (1991) (0)
activation by 14,15-epoxyeicosatrienoic acid channel ATP Mechanism of rat mesenteric arterial K (2016) (0)
20‐HETE Increases Large Artery Stiffness and Systolic Blood Pressure in Metabolic Syndrome (2016) (0)
Inhibition of Vascular Smooth Muscle Cell Migration by an Endothelium‐derived 15‐Lipoxygenase Metabolite, 11,12,15‐Trihydroxyeicosatrienoic Acid (2015) (0)
An epoxyeicosatrienoic acid analog treated adriamycin‐induced proteinuria and renal fibrosis (2017) (0)
GRIGNARD ADDITIONS TO ALPHA ,BETA -UNSATURATED DIOXOLANONES : PREPARATION OF CHIRAL ALLYLIC ALCOHOLS AND PROTECTED ALPHA -HYDROXY ALDEHYDES (1996) (0)
Abstract 404: 20-HETE Regulates Angiogenic Functions of Human Endothelial Progenitor Cells and Contributes to Ischemia-induced Compensatory Neovascularization (2013) (0)
Heterocyclic [4+ + 2] cycloadditions: the reactivity of pyridinium salts with electron-rich olefins (1990) (0)
Amide-Directed Tandem C—C/C—N Bond Formation Through C—H Activation. (2012) (0)
ELECTROOXIDATIVE SYNTHESIS OF MORPHINANDIONES FROM 1-BENZYLTETRAHYDROISOQUINOLINES (1974) (0)
Abstract 015: Increased 20-HETE Levels Contribute to Impaired Glucose Metabolism and Type 2 Diabetes in Cyp4a14 Knockout Mice Fed on High Fat Diet. (2015) (0)
Dependent Repression of Cyclin D 1 − α Proliferator-Activated Receptor Inhibition of Smooth Muscle Proliferation by Urea-Based Alkanoic Acids via Peroxisome (2006) (0)
Pharmacological blockade of the 20‐HETE receptor (GPR75) lowers blood pressure and alters vascular remodeling in mice with vascular smooth muscle‐specific overexpression of CYP‐4a12‐20‐HETE synthase (2020) (0)
Acute hypotensive effect of EET‐A, a stable analog of epoxyeicosatrienic acid (EET), in spontaneously hypertensive rats: dependence on endogenous EETs activity (2020) (0)
Epoxyeicosatrienoic Acid Analogs Reduce Renal Fibrosis By Reducing Epithelial‐To Mesenchymal‐Transition (2016) (0)
Reactivity of α‐Mesyloxystannanes with Organocopper Reagents: Preparation of Chiral Stannanes. (1994) (0)
Cytochrome P- 450 v -hydroxylase: a potential O 2 sensor in rat arterioles and skeletal muscle cells (2001) (0)
Abstract 662: The Acute Hypoxic Pulmonary Vasoconstrictor Response And Pulmonary Artery Pressure Are Modified By The Soluble Epoxide Hydrolase And Epoxyeicosatrienoic Acids. (2007) (0)
Abstract 648: Metabolism of Adrenic Acid to Vasodilatory 1{alpha}, 1{beta}-Dihomo-epoxyeicosatrienoic Acids by Bovine Coronary Arteries (2006) (0)
Novel Formation of 1,3‐Oxazepine Heterocycles (II) via Palladium‐Catalyzed Intramolecular Coupling Reaction. (2007) (0)
Efficient N-Arylation of Pyridazin-3(2H)-ones. (2005) (0)
20‐HETE INDUCES REMODELING OF RENAL RESISTANCE ARTERIES INDEPENDENT OF BLOOD PRESSURE ELEVATION IN ANDROGEN‐INDUCED HYPERTENSION (2013) (0)
Hydroxyeicosatetraensäureanaloge and process their use for the treatment of dry eye (2000) (0)
Corrigendum to "Elevated 20-HETE in metabolic syndrome regulates arterial stiffness and systolic hypertension via MMP12 activation" [J. Mol. Cell. Cardiol. 117 (2018) 88-99]. (2018) (0)
Efficient Iridium-Catalyzed C—H Functionalization/Silylation of Heteroarenes. (2009) (0)
Differential Cleavage of Arylmethyl Ethers: Reactivity of 2,6‐Dimethoxybenzyl Ethers. (2001) (0)
Enantiospecific Synthesis of D-myo-Inositol 1,4,5-Trisphosphate (II) from (-)-Quinic Acid (I). (1990) (0)
Abstract 3568: CYP3A4 epoxygenase activity mediates ER+ mammary tumor growth and angiogenesis, in part, through EET biosynthesis and is inhibited by biguanides (2015) (0)
Abstract 105: 20-HETE: An Inducer of ACE in Human Microvascular Endothelial Cells (HMVEC). (2012) (0)
Abstract 405: Role of Adherent Platelets in 12-lipoxygenase-mediated Vascular Relaxation in Mouse Arteries (2013) (0)
The CYP4A/20‐HETE Axis Regulates Ischemia‐induced Neovascularization via Its Actions on Endothelial Progenitor and Preexisting Endothelial Cells (2019) (0)
ALKALOIDS OF THE PAPAVERACEAE PART 20, 2,9-DIMETHOXY-3-HYDROXYPAVINANE, A NEW ALKALOID FROM ARGEMONE MUNITA SUBSP. ROTUNDATA (1974) (0)
of Lipoxygenase-Expressing Airway Facilitates Neutrophilic Breach 3 Hepoxilin A (2012) (0)
Direct Stereospecific Synthesis of Unprotected NH / NMe Aziridines from Olefins (2014) (0)
Erratum: Copper(I)-promoted thiophenoxide ionization in solution. A simple synthesis of vinyl phenyl sulfides (Journal of Organic Chemistry (1975) 40, (812)) (1975) (0)
Abstract P2029: Cytochrome P450 (CYP) 1B1-Estradiol Metabolite 2-Methoxyestradiol Protects Against Angiotensin II-induced Hypertension By Inhibiting CYP4A1 Expression 20-Hydroxyeicosatetraenoic Acid (20-HETE) Production In The Female Mice (2019) (0)
Neutrophil‐derived 20‐HETE Is a Major Determinant of Coronary Collateral Growth (2016) (0)
Advances in Brief 2-Arachidonoylglycerol : A Novel Inhibitor of Androgen-Independent Prostate Cancer Cell Invasion (2004) (0)
Highly Stereoselective Synthesis of (Z,E)-1-Halo-1,3-dienol Esters via Rearrangement of Fischer Chromium Chlorocarbenes Using Microwave Irradiation. (2009) (0)
Stereospecific Cross-Coupling ofα-(Thiocarbamoyl)organostannanes (2007) (0)
Synthesis of Alkyl Nitronates via Mitsunobu Condensation. (1993) (0)
Palladium-Mediated Allylic Mitsunobu Displacement: Stereocontrolled Synthesis of Hepoxilin A3 and Trioxilin A3 Methyl Esters. (1992) (0)
An Efficient Synthesis of [1,4]Pyridazinooxazine[3,4‐a]tetrahydro Isoquinolines. (2004) (0)
α-Haloenol Acetates: Versatile Reactants for Oxetan-2-one, Azetidin-2-one and Isoxazolidin-5-one Synthesis. (2007) (0)
Dual Role of 20‐HETE and Angiotensin II Suppression in Contributing to Vascular Dysfunction in Cerebral Arteries of Dahl Salt‐Sensitive Rats (2011) (0)
Copper-Catalyzed Coupling of Peptidic Thiol Esters and α-Alkoxyalkylstannanes (2011) (0)
Vasoactive Eicosanoids: Synthesis of 12,20-Dihydroxyeicosa-5(Z),8(Z), 10(E),14(Z)-tetraenoic Acid via a Novel Chiral Bis-Lactol. (1995) (0)
Abstract 404: The Role of 20-HETE in the Regulation of Endothelial Progenitor Cell Stemness (2015) (0)
Synthesis of (S)-(+)-Mevalonolactone and Mevalonate Analogues. (2010) (0)
A deficiency in the formation of 20‐HETE impairs the myogenic and TGF responses of the Af‐Art of Dahl salt sensitive rats (857.8) (2014) (0)
A Concise Synthesis of (R)-Hydroxy-E,Z-diene Fatty Acids: Preparation of 12(R)-HETE, Tetranor-12(R)-HETE, and 13(R)-HODE. (1992) (0)
Development of combined soluble epoxide hydrolase inhibitors and epoxide analogs with vasodilator activity (2009) (0)
Abstract 064: 20-HETE Contributes to Vasoconstriction of Renal Microvessels and Sodium Retention in Cyp4a14-/- Mice, a Model of 20-HETE Dependent Hypertension (2015) (0)
Synthesis of the Polycyclopropane Antibiotic FR‐900848 via the Horeau Gambit. (1996) (0)
Synthesis and Stereochemical Revision of a Bioactive Dihydroxyeicosanoid Isolated from the Red Marine Alga Farlowia mollis. (1991) (0)
SmI2-Mediated Reductive Addition of Bis-Phenylsulfones to Ketones. (1994) (0)
Stereoselective CrCl2‐Mediated Condensation of Aldehydes with Functionalized 1,1,1‐Trichlorides: Synthesis of Trisubstituted (Z)‐Chloroolefins. (2004) (0)
A novel epoxyeicosatrienoic acid analog attenuates hypertension and renal injury in Cyp2c44 KO mice (2013) (0)
Organocatalytic Oxy-Michael Addition (2008) (0)
Preparation of O‐Alkylhydroxamic Acids Using 2‐Acylpyridazin‐3(2H)‐ones in Water. (2005) (0)
Two-Carbon Elongation/Annulation of Alcohols to Nitriles. (2010) (0)
Altered EDHF‐mediated dilation in spontaneously hypertensive rats following enalapril treatment (2009) (0)
Stereospecific Suzuki Cross-Coupling (2010) (0)
Cr(II)-Mediated Cascade Reactions of tert-Trihalomethylcarbinols (2006) (0)
Renal Hemodynamics : Integration with the Nephron and Beyond Role of 20-HETE in the impaired myogenic and TGF responses of the Af-Art of Dahl salt-sensitive rats (2014) (0)
Abstract LB564: (±) 14,15-epoxyeicosatrienoic acid induces hallmark ER and MYC gene expression and associated ER and c-Myc nuclear translocation in ER+/HER2- breast cancer cells (2022) (0)
Convenient Preparation of α‐Trimethylsilyloxy‐ and α‐ Hydroxystannanes from Aldehydes. (1994) (0)
Rhodium-Catalyzed Synthesis of Isoindolinones via C—H Activation of N-Benzoylsulfonamides. (2013) (0)
Vascular Endothelial ACE Deletion does not Prevent 20‐HETE‐dependent Vascular Remodeling (2015) (0)
Erythrocyte hydrolysis of cis‐ and trans‐epoxyeicosatrienoic acids (2007) (0)
Methyl Carboxymethylenation of Alcohols via Dehydrative Alkylation. (1996) (0)
Hydroxyeicosatetraenoic acid analogs and methods for their use for the treatment of öjentörhedslidelser (2000) (0)
100 THE ROLE OF 20-HETE IN PROSTATE CANCER-TUMOR VASCULATURE (2012) (0)
Intramolecular Mitsunobu Displacement with Carbon Nucleophiles: Preparation of α‐Nitrocyclopropanes. (1992) (0)
Chronic administration of the soluble epoxide hydrolase (sEH) inhibitor, AUDA, ameliorates end‐organ damage in stroke‐prone hypertensive rats (SHRSP) (2008) (0)
Hyperpolarizing Factor in Rabbit Arteries as an Acid-stable Endothelium-derived Acid 13-Hydroxy-14 , 15-epoxyeicosatrienoic Identification of Regulation , and Signaling : Lipids and Lipoproteins : Metabolism (2009) (0)
implications for soluble epoxide hydrolase inhibition channels: Ca dilate human coronary arterioles via BK Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids (2006) (0)
Abstract 507: G Proteins are Required for Lipoxygenase EDHF Activity of Rabbit Arterial Smooth Muscle Cells (2012) (0)
Hepoxilins B3: Synthesis of All Four Stereoisomers and a Glutathione Adduct. (1994) (0)
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMPPNP and inositol hexakisphosphate (IP6) (2011) (0)
Stereospecific Synthesis of trans‐Arachidonic Acids. (2001) (0)
Practical, Asymmetric Synthesis of 16-Hydroxyeicosa-5(Z),8(Z),11(Z), 14(Z)-tetraenoic Acid (16-HETE), an Endogenous Inhibitor of Neutrophil Activity. (2004) (0)
1,5‐ADDITION OF DIALKYLCUPRATE REAGENTS TO ALKYLCYCLOPROPYL KETONES (1984) (0)
Enantioselective Reduction of Ketones - A NewAlternative to the CBS Reduction? (2010) (0)
Novel Epoxyeicosatrienoic Acid (EET) Analogs Increase Sodium Excretion and Lower Blood Pressure in Hypertension (2011) (0)
Triphenylphosphine Hydrobromide: A Mild and Efficient Catalyst for Tetrahydropyranylation of Tertiary Alcohols (I). (1989) (0)
Hydroxyicosatetraensyreanaloger and methods for their use in treating öjentörhedslidelser (2000) (0)
Abstract 607: Antiarrhythmic Effects Of Omega-3 Fatty Acids And Cyp-eicosanoids In A Murine Atrial Fibrillation Model (2012) (0)
SEX-SPECIFIC CHANGES OF THE RENAL CYP-EICOSANOID PROFILE LEAD TO GENDER DIMORPHISM IN EXPERIMENTAL ACUTE KIDNEY INJURY: 2097 (2010) (0)
Regioselective De-O-benzylation of Monosaccharides. (2010) (0)
Modulation ofarteriolar bloodflowbyinhibitors of arachidonic acidoxidation after thermal injury: possible rolefora novel class ofvasodilator metabolites (2011) (0)
Reductive Lithiation of Bis-Phenylsulfones. (1994) (0)
CALL FOR PAPERS Regulation of Cardiovascular Functions by Eicosanoids and Other Lipid Mediators 14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor- (2006) (0)
Jat Aziridines from Olefins Direct Stereospecific Synthesis of Unprotected NH and NMe (2014) (0)
Soluble epoxide hydrolase (sEH) inhibitor, AUDA, prevents the early salt‐sensitive component of hypertension in stroke‐prone spontaneously hypertensive rats (SHRSP). (2007) (0)
Eicosanoid Biosynthesis: Differential Inhibition of Cytochrome P450 Epoxygenase and ω-Hydroxylase. (2010) (0)
New group of lipid mediators containing omega-hydroxyarachadonic acid (20-HETE). (1997) (0)
A Convenient Synthesis of Unsymmetric Polyfluoroethers. (1995) (0)
Identifying the 20‐HETE Binding Site on the 20‐HETE Receptor (GPR75) (2020) (0)
The role of endothelial-derived hyperpolarizing factor in tissue-type plasminogen activator release (2003) (0)
20–HETE and cytochrome P450 4A may have a role in regulation of angiogenesis. (2004) (0)
Total Synthesis of 5(S),20- and 15(S),20-Dihydroxyeicosatetraenoic Acid and 5(S),6(R)-Epoxy-20-hydroxy- and 14(R),15(S)-Epoxy-20-hydroxyeicosatrienoic Acid. (1987) (0)
Does Malfunction of Arachidonic Acid Epoxygenase Explain Salt-Sensitive Hypertension?: Salt-Sensitive Hypertension Is Associated with Dysfunctional Cyp4a10 Gene and Kidney Epithelial Sodium Channel. J Clin Invest 116: 1696-1702, 2006. (2006) (0)
Abstract 29: An Orally Active Epoxyeicosatrienoic Acid (eet) Analog Attenuates Kidney Injury in Hypertensive Dahl Salt Sensitive Rat by Reducing Oxidative Stress, Inflammation and Endoplasmic Reticulum Stress (2012) (0)
Efficient Total Synthesis of 5-Oxo-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic Acid (5-Oxo-ETE), a Potent Proinflammatory Autacoid. (2002) (0)
Abstract 44: Hexyl-benzyl-biguanide (HBB) potently and selectively inhibits CYP3A4 epoxygenase activity and inhibits EET stabilization of mitochondrial respiration in ER+HER2- breast cancer cells, inducing glycolysis and pyruvate biosynthesis (2016) (0)
OXAZOLINE CHEMISTRY. PREPARATION OF ISOQUINOLINES AND 2,2′-BISOXAZOLINES (1982) (0)
Nitric oxide and NO-independent mechanisms mediate ETB receptor buffering of ET-1-induced renal vasoconstriction in the rat-- MS R-00550-2004 , Final Accepted Version-- (2004) (0)
Stereospecific Dehydrative Alkylation of Bis‐Sulfones: Synthesis of a Lesser Tea Tortrix Pheromone. (1994) (0)
20-HETE/GPR75 pairing modulates the expression and transcriptional activity of the androgen receptor in androgen-sensitive prostate cancer cells (2022) (0)
Epoxyeicosatrienoic acid-based therapIES attenuate POSTISCHEMIC heart failure progression IN NORMOTENSIVE SPRAGUE-DAWLEY rats but not in ANIMALS with Angiotensine II-dependent hypertension (2018) (0)
The NADPH-dependent microsomal metabolism of arachidonic acid (1984) (0)
Three-Component Synthesis of 2-Haloalk-2(Z)-en-1-ols via Tandem Haloalkylidenation—Aldehyde Addition. (2002) (0)
ChemInform Abstract: Ag(I)-Promoted Suzuki-Miyaura Cross-Couplings of n-Alkylboronic Acids. (2002) (0)
Abstract 111: A Kidney Targeted Epoxyeicosatrienoic Acid Analog, EET-F01, Reduces Cisplatin-induced Nephrotoxicity (2017) (0)
A Convenient Synthesis of Pyrido(3,4-g)isoquinoline via ortho-Directed Metalation/Dimerization. (1988) (0)
Abstract 283: Protective Role of Endogenous 20-HETE in Renal Ischemia-Reperfusion Injury (2013) (0)
Novel Conversion of Epoxides to One Carbon Homologated Allylic Alcohols by Dimethylsulfonium Methylide. (1994) (0)
Abstract 024: 20-HETE Activates the Transcription of Endothelial Angiotensin Converting Enzyme (ACE) via NF-kB Translocation and Promoter Binding (2014) (0)
Synthesis and Biological Evaluation of Pyridooxazine—Tetrahydroisoquinoline Derivatives as MDR Modulators. (2007) (0)
Contribution of PPARα/β/γ, AP-1, importin-α3, and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock (2016) (0)
Role of PPAR‐γ in A2AAR‐mediated vascular relaxation in high salt‐fed mice (849.4) (2014) (0)
Stereospecific Synthesis of EET Metabolites via Suzuki—Miyaura Coupling. (2010) (0)
20-HETE Is a Nonhypoxic Regulator of HIF in Endothelial Cells (2008) (0)
Effect of Chronically Suppressed Plasma Angiotensin II on Regulation of the CYP4A/20-HETE Pathway in the Dahl Salt-Sensitive Rat (2023) (0)
22nd Meeting of the ESM, August 2002 (2001) (0)
20- 125 Iodo-14,15-Epoxyeicosa-5( Z )-enoic Acid: a High-Affinity Radioligand Used to Characterize the Epoxyeicosatrienoic Acid Antagonist Binding Site □ S (2009) (0)
Interaction of adenosine and cytochrome P450 epoxygenase pathways in neurovascular coupling during whisker stimulation (2005) (0)
Disruption of soluble epoxide hydrolase modulates adenosine‐induced response: role of adenosine A2A receptor and cyp‐epoxygenases (2012) (0)
Salt‐Induced Increase in 20‐HETE Production Alters Vascular Function of Mesenteric Resistance Arteries of Dahl Salt‐Sensitive Rats (2010) (0)
Direct Anomeric Substitution of Pyranyl Esters Using Organocopper Reagents. (1990) (0)
Cell-cell interactions in the eicosanoid pathways. (1988) (0)
Epoxyeicosatrienoic Acid Analog Reduces Proteinuria And Renal Cast Formation In Experimental Radiation Nephropathy (2016) (0)
Terpenoid Chirons: Preparation and Transformations of 2-Hydroxy-1,1,4a( R),6-tetramethyl-trans-δ5,6-octalin. (1994) (0)
WX-III-287-19 A Possible Thromboxane Antagonist in Bovine Coronary Arteries. (2014) (0)
8,9‐Dihydroxyeicosatrienoic acid does not protect the glomerular filtration barrier (2009) (0)
Tumor and Stem Cell Biology PPAR a ActivationCanHelpPrevent andTreatNon – SmallCell Lung Cancer (2014) (0)
Epoxides Attenuate Adipogenesis in human Mesenchymal Stem Cells via Activation of Heme Oxygenase‐Adiponectin Pathways (2011) (0)
Abstract 295: The Role of 20-HETE in the Control of Prostate Cancer Tumor Vasculature (2012) (0)
TRANSFORMATION OF 15-HETE TO 14,15-DIHYDROXYEICOSATRIENOIC ACID AND 11,14,15- AND 13,14,15-TRIHYDROXYEICOSATRIENOIC ACIDS (1984) (0)
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ATP and Cadmium (2011) (0)
Hypoxia inducible factor‐1 alpha contributes to infarct size‐limiting effect of postconditioning afforded by epoxyeicosatrienoic acid analog in rat hearts. (1080.2) (2014) (0)
Preparation of (Z)‐1‐Halo‐1‐alkenes and (Z)‐1‐Halo‐2‐alkoxy‐1‐alkenes Using Cr(II)/(III) and Fe(0). (2007) (0)
Nucleophilic Substitution at the Acetalic Center of Mandelate 1,3‐ Dioxolan‐4‐ones Using Magnesio‐Copper Reagents: Application to the Synthesis of Chiral Secondary Alcohols. (1993) (0)
Abstract 655: Ischemia-induced Epoxyeicosatrienoic Acid Release Protects Female Rats From Acute Kidney Injury (2012) (0)
Erratum (2014) (0)
Dilation of skeletal muscle resistance arteries to incremental hypoxia An integration of signaling pathways (2002) (0)
C001: Inhibition of 20-HETE lowers blood pressure in rats with Angiotensin II (ANG II) induced hypertension following no inhibition (1998) (0)
Characterization of a 14,15‐ Epoxyeicosatrienoic Acid Binding Site/Receptor with a New Agonist Ligand 14,15‐Epoxyeicosatrienoic‐Phenyliodosulfonylamide (2005) (0)
Arachidonsyreanaloge analgesic, and methods of treatment using thereof (2010) (0)
Salt modulates vascular response through cyp‐epoxygenases in the presence of A2A AR (2012) (0)
Epoxyeicosatrienoic acids (EET) contribute to flow‐induced dilation in mice mesenteric resistance artery (2009) (0)
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and in the absence of cadmium at pH 7.0 (2011) (0)
rat chromosome 5 defined using congenic Dahl rats Two closely linked interactive blood pressure QTL on (2015) (0)
Abstract 263: 20-hete-induced Vascular Remodeling in Models Of Androgen-dependent and Independent Hypertension (2012) (0)
Contribution of NLRP3 Inflammasome to the Protective Effect of 5,14-HEDGE, A 20-HETE Mimetic, against LPS-Induced Septic Shock in Rats (2017) (0)
transfusion of cell-free polymeric hemoglobin response to decreased hematocrit after exchange Role of 20-HETE in the pial arteriolar constrictor (2015) (0)
Modulation of vascular response by high salt intake depends on the presence or absence of adenosine A2A receptor using A2A AR‐null mice (2013) (0)
Structure‐Function Relationship of the 20‐HETE‐GPR75 pairing: Development and characterization of agonist, partial agonists, and receptor blockers (2022) (0)
Cytochrome P450 epoxygenase inhibition attenuates hypoxia-induced pulmonary vasoconstriction and vascular remodelling in mice (2005) (0)
Chiral Acetals: Stereocontrolled Syntheses of 16‐, 17‐, and 18‐ Hydroxyeicosatetraenoic Acids, Cytochrome P‐450 Arachidonate Metabolites. (2010) (0)
Increased Endothelial Expression of Human Cytochrome P450 Epoxygenase 2J2 Positively Modulates Coronary Reactive Hyperemia in Isolated Mouse Heart (2015) (0)
20‐HETE agonist, N‐[20‐hydroxyeicosa‐5(Z),14(Z)‐dienoyl]glycine, opposes the endotoxin‐induced fall in blood pressure and the decrease in vascular reactivity and lipid peroxidation and increased catalase activity via inhibition of NO production in rats (2008) (0)
Chiral alpha,beta-dialkoxy- and alpha-alkoxy-beta-aminostannanes: preparation and copper-mediated cross-coupling. (2003) (0)
Mannosylation of a synthetic gpi precursor by hamster membranes requires prior palmttoyl-CoA dependent acylation (1996) (0)
Synthesis of Bicyclic Fused Carbocycles via Intramolecular Dehydrative Alkylation. (1996) (0)
Abstract 4372: Metformin inhibits nuclear localization of estrogen receptor alpha in breast cancer cells, in part, by inhibition of CYP-mediated epoxyeicosatrienoic acid (EET) biosynthesis (2020) (0)
cP450 Epoxygenase exerts potent cytoprotective effects by a dual mechanism in renal epithelial cells (1999) (0)
Regulation of Cardiovascular Functions by Eicosanoids and Other Lipid Mediators 14 , 15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor - (2005) (0)
Stereoselective Synthesis of Methyl (Z)-α-Methoxyacrylates via Two-Carbon Homologation of Aldehydes. (2009) (0)
Modified Pyridinium Chlorochromate Oxidation of Aldehydes to Carbamoyl Azides/Acyl Azides or Carboxylic Acids. (1988) (0)
Activates the Transcription of Angiotensin-Converting Enzyme via Nuclear Factor-k B Translocation and Promoter Binding (2016) (0)
EDHG-like responses in rat cremaster muscle arterioles involve IK Ca and SK Ca channels, and CYP-450 metabolites (2005) (0)
cytochrome P450- dependent metabolites of arachidonic acid Modulation of erythropoiesis by novel human bone marrow (2011) (0)
produced by a cytochrome P450 monooxygenase Intestinal vasodilation by epoxyeicosatrienoic acids: arachidonic acid metabolites (2011) (0)
Effective Antihypertensive Treatment with Epoxyeicosatrienoic Acid Analog (EET‐A) and 20‐HETE Antagonist (AAA) of Spontaneously Hypertensive Rats (SHR) (2020) (0)
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP, 5-(PP)-IP5 (5-IP7) and MgF3 (transition state mimic) (2011) (0)
Characterization of GPR40 as a Low Affinity Epoxyeicosatrienoic Acid (EET) Receptor in Vascular Cells (2017) (0)
vic‐Diol Chirons: Enantiospecific Synthesis of 11,12‐ and 14,15‐ Dihydroxyeicosatrienoic Acids. (1995) (0)
APPLICATION OF COPPER(I)-INDUCED THIOPHENOXIDE REMOVAL TO RING EXPANSIONS OR CHAIN EXTENSIONS OF ALDEHYDES AND KETONES, DETECTION, ISOLATION, AND INDEPENDENT PREPARATION OF THE ALPHA-EPOXY THIOETHER INTERMEDIATE (1975) (0)
Stimulation of the synthesis of 15-hydroxyeicosatetraenoic acid (15-HETE) and 6-keto-prostaglandin F/sub 1. cap alpha. / (6-keto-PGF/sub 1. cap alpha. /) by cultured human umbilical veins (1986) (0)

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