John Robert Perfect
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John Robert Perfect's Degrees
- Doctorate Medicine University of Pennsylvania
- PhD Microbiology University of Pennsylvania
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(Suggest an Edit or Addition)John Robert Perfect's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. (2008) (4348)
- Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america. (2010) (2128)
- Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia. (2007) (1287)
- Comparison of caspofungin and amphotericin B for invasive candidiasis. (2002) (1093)
- Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium (2019) (1062)
- Practice guidelines for the management of cryptococcal disease. Infectious Diseases Society of America. (2000) (1044)
- Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans (1995) (982)
- Voriconazole compared with liposomal amphotericin B for empirical antifungal therapy in patients with neutropenia and persistent fever. (2002) (943)
- Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trial. (2007) (725)
- Human dectin-1 deficiency and mucocutaneous fungal infections. (2009) (698)
- Voriconazole treatment for less-common, emerging, or refractory fungal infections. (2003) (651)
- Amphotericin B lipid complex for invasive fungal infections: analysis of safety and efficacy in 556 cases. (1998) (614)
- Cryptococcosis in human immunodeficiency virus-negative patients in the era of effective azole therapy. (2001) (588)
- Combination Antifungal Therapy (2004) (515)
- Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak (2005) (493)
- Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA (1993) (490)
- Urease as a Virulence Factor in Experimental Cryptococcosis (2000) (477)
- Calcineurin is required for virulence of Cryptococcus neoformans (1997) (477)
- Isavuconazole treatment for mucormycosis: a single-arm open-label trial and case-control analysis. (2016) (467)
- The impact of culture isolation of Aspergillus species: a hospital-based survey of aspergillosis. (2001) (463)
- An official American Thoracic Society statement: Treatment of fungal infections in adult pulmonary and critical care patients. (2011) (458)
- Defining and managing COVID-19-associated pulmonary aspergillosis: the 2020 ECMM/ISHAM consensus criteria for research and clinical guidance (2020) (454)
- The antifungal pipeline: a reality check (2017) (454)
- Voriconazole in the treatment of aspergillosis, scedosporiosis and other invasive fungal infections in children (2002) (413)
- Antimicrobial resistance: resistance to antifungal agents: mechanisms and clinical impact. (2008) (407)
- Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP. (1997) (407)
- Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans (1996) (395)
- Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages. (1990) (372)
- Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans (2001) (356)
- Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease (2009) (356)
- Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria. (2008) (355)
- Sexual Cycle of Cryptococcus neoformans var. grubii and Virulence of Congenic a and α Isolates (2003) (335)
- Calcineurin is essential for survival during membrane stress in Candida albicans (2002) (334)
- Zygomycosis: the re-emerging fungal infection (2006) (330)
- Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages. (1988) (328)
- Cyclic AMP-Dependent Protein Kinase Controls Virulence of the Fungal Pathogen Cryptococcus neoformans (2001) (318)
- Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence Attenuation (2014) (316)
- Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide. (1985) (313)
- Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis (2002) (312)
- Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections (2007) (304)
- Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin (2009) (296)
- Hsp90 Orchestrates Temperature-Dependent Candida albicans Morphogenesis via Ras1-PKA Signaling (2009) (295)
- Infections due to Aspergillus terreus: a multicenter retrospective analysis of 83 cases. (2004) (292)
- The Case for Adopting the “Species Complex” Nomenclature for the Etiologic Agents of Cryptococcosis (2017) (288)
- Chronic cryptococcal meningitis: a new experimental model in rabbits. (1980) (266)
- Calcineurin Controls Growth, Morphology, and Pathogenicity in Aspergillus fumigatus (2006) (259)
- PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90 (2010) (259)
- Superoxide Dismutase Influences the Virulence of Cryptococcus neoformans by Affecting Growth within Macrophages (2003) (257)
- The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial. (2011) (245)
- Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasion. (2004) (234)
- Immune reconstitution syndrome associated with opportunistic mycoses. (2007) (222)
- The new fungal opportunists are coming. (1996) (222)
- RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans (2000) (218)
- The spectrum of fungi that infects humans. (2014) (215)
- Disruption of a Nonribosomal Peptide Synthetase in Aspergillus fumigatus Eliminates Gliotoxin Production (2006) (208)
- Adenylyl Cyclase Functions Downstream of the Gα Protein Gpa1 and Controls Mating and Pathogenicity of Cryptococcus neoformans (2002) (206)
- Safety of long-term oral posaconazole use in the treatment of refractory invasive fungal infections. (2006) (206)
- Phase I Evaluation of the Safety and Pharmacokinetics of Murine-Derived Anticryptococcal Antibody 18B7 in Subjects with Treated Cryptococcal Meningitis (2005) (199)
- Cryptococcosis in solid organ transplant recipients: current state of the science. (2008) (195)
- Penetration of new azole compounds into the eye and efficacy in experimental Candida endophthalmitis (1987) (193)
- Breakthrough Invasive Candidiasis in Patients on Micafungin (2010) (192)
- Comparative safety of amphotericin B lipid complex and amphotericin B deoxycholate as aerosolized antifungal prophylaxis in lung-transplant recipients (2004) (191)
- Cryptococcosis diagnosis and treatment: What do we know now. (2015) (187)
- Karyotyping of Cryptococcus neoformans as an epidemiological tool (1993) (186)
- Calcineurin Is Essential for Candida albicans Survival in Serum and Virulence (2003) (186)
- Structure-In Vitro Activity Relationships of Pentamidine Analogues and Dication-Substituted Bis-Benzimidazoles as New Antifungal Agents (1998) (186)
- Morphologic criteria for the preliminary identification of Fusarium, Paecilomyces, and Acremonium species by histopathology. (1998) (182)
- Infection due to Actinobacillus actinomycetemcomitans: 15 cases and review. (1989) (181)
- Carbonic Anhydrase and CO2 Sensing during Cryptococcus neoformans Growth, Differentiation, and Virulence (2005) (181)
- Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbits (1986) (180)
- CX3CR1-dependent renal macrophage survival promotes Candida control and host survival. (2013) (178)
- Interlaboratory Comparison of Results of Susceptibility Testing with Caspofungin against Candida and Aspergillus Species (2004) (177)
- The G-Protein β Subunit GPB1 Is Required for Mating and Haploid Fruiting in Cryptococcus neoformans (2000) (177)
- A Glucan Synthase FKS1 Homolog inCryptococcus neoformans Is Single Copy and Encodes an Essential Function (1999) (177)
- Prophylactic intravenous amphotericin B in neutropenic autologous bone marrow transplant recipients. (1992) (174)
- Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans (2000) (170)
- Synergistic Antifungal Activities of Bafilomycin A1, Fluconazole, and the Pneumocandin MK-0991/Caspofungin Acetate (L-743,873) with Calcineurin Inhibitors FK506 and L-685,818 against Cryptococcus neoformans (2000) (170)
- Immune reconstitution syndrome and exacerbation of infections after pregnancy. (2007) (168)
- Fungal Infections in Lung and Heart‐Lung Transplant Recipients: Report of 9 Cases and Review of the Literature (1996) (168)
- Prevention and early treatment of invasive fungal infection in patients with cancer and neutropenia and in stem cell transplant recipients in the era of newer broad-spectrum antifungal agents and diagnostic adjuncts. (2007) (167)
- Resistance to Antifungal Agents: Mechanisms and Clinical Impact (2007) (165)
- Protection against Cryptococcosis by Using a Murine Gamma Interferon-Producing Cryptococcus neoformans Strain (2007) (161)
- Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans (2013) (160)
- Treatment of methicillin-resistant staphylococcus aureus infections with quinupristin-dalfopristin in patients intolerant of or failing prior therapy. For the Synercid Emergency-Use Study Group. (2000) (159)
- Rapamycin Antifungal Action Is Mediated via Conserved Complexes with FKBP12 and TOR Kinase Homologs inCryptococcus neoformans (1999) (158)
- Plasminogen Alleles Influence Susceptibility to Invasive Aspergillosis (2008) (158)
- Treatment of non-Aspergillus moulds in immunocompromised patients, with amphotericin B lipid complex. (2005) (157)
- Calcineurin Target CrzA Regulates Conidial Germination, Hyphal Growth, and Pathogenesis of Aspergillus fumigatus (2008) (151)
- Correlation of in vitro fluconazole resistance of Candida isolates in relation to therapy and symptoms of individuals seropositive for human immunodeficiency virus type 1 (1993) (151)
- Targeted gene replacement demonstrates that myristoyl-CoA: protein N-myristoyltransferase is essential for viability of Cryptococcus neoformans. (1994) (151)
- Pulmonary cryptococcosis in patients without HIV infection: factors associated with disseminated disease (2008) (151)
- Isavuconazole Treatment of Cryptococcosis and Dimorphic Mycoses (2016) (150)
- Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans. (2003) (149)
- Comparison and Temporal Trends of Three Groups with Cryptococcosis: HIV-Infected, Solid Organ Transplant, and HIV-Negative/Non-Transplant (2012) (148)
- SAFETY OF AEROSOLIZED AMPHOTERICIN B LIPID COMPLEX IN LUNG TRANSPLANT RECIPIENTS12 (2001) (148)
- In vitro antifungal activity of pneumocandin L-743,872 against a variety of clinically important molds (1997) (147)
- Cryptococcus gattii: an emerging fungal pathogen infecting humans and animals. (2011) (146)
- Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates. (2003) (146)
- Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection (2008) (145)
- Disseminated zygomycosis: report of four cases and review. (1989) (143)
- Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans. (2001) (141)
- Azole antifungals: 35 years of invasive fungal infection management (2015) (139)
- Risk of Fungemia Due to Rhodotorula and Antifungal Susceptibility Testing of Rhodotorula Isolates (2003) (139)
- Differential Effects of Inhibiting Chitin and 1,3-β-d-Glucan Synthesis in Ras and Calcineurin Mutants of Aspergillus fumigatus (2008) (139)
- Characterization and Regulation of the Trehalose Synthesis Pathway and Its Importance in the Pathogenicity of Cryptococcus neoformans (2006) (139)
- Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinct. (2000) (139)
- Rapamycin and Less Immunosuppressive Analogs Are Toxic to Candida albicans and Cryptococcus neoformans via FKBP12-Dependent Inhibition of TOR (2001) (138)
- Combined therapy with amphotericin B and 5-fluorocytosine for Candida meningitis. (1984) (134)
- Mortality, length of hospitalization, and costs associated with invasive fungal infections in high-risk patients. (2009) (134)
- The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein (1997) (134)
- The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans. (1999) (131)
- Toll-like receptor 1 polymorphisms increase susceptibility to candidemia. (2012) (131)
- Transcriptional Regulation of Chitin Synthases by Calcineurin Controls Paradoxical Growth of Aspergillus fumigatus in Response to Caspofungin (2010) (130)
- Role of PLB1 in Pulmonary Inflammation and Cryptococcal Eicosanoid Production (2003) (129)
- Gpr1, a Putative G-Protein-Coupled Receptor, Regulates Morphogenesis and Hypha Formation in the Pathogenic Fungus Candida albicans (2004) (127)
- Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi. (2017) (126)
- Cryptococcus neoformans α Strains Preferentially Disseminate to the Central Nervous System during Coinfection (2005) (125)
- In Vitro Interactions between Antifungals and Immunosuppressants against Aspergillus fumigatus (2004) (125)
- The gene encoding phosphoribosylaminoimidazole carboxylase (ADE2) is essential for growth of Cryptococcus neoformans in cerebrospinal fluid (1993) (125)
- Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans (2001) (124)
- Cryptococcus neoformans Gene Expression during Experimental Cryptococcal Meningitis (2003) (123)
- Quantitation of Candida CFU in Initial Positive Blood Cultures (2011) (121)
- Immunosuppressive and Nonimmunosuppressive Cyclosporine Analogs Are Toxic to the Opportunistic Fungal Pathogen Cryptococcus neoformans via Cyclophilin-Dependent Inhibition of Calcineurin (2000) (121)
- In vitro and in vivo efficacies of the azole SCH56592 against Cryptococcus neoformans (1996) (121)
- Fungi that Infect Humans. (2017) (121)
- Global Distribution and Outcomes for Candida Species Causing Invasive Candidiasis: Results from an International Randomized Double-Blind Study of Caspofungin Versus Amphotericin B for the Treatment of Invasive Candidiasis (2003) (120)
- A MAP kinase cascade composed of cell type specific and non‐specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans (2003) (120)
- Diguanidino and "reversed" diamidino 2,5-diarylfurans as antimicrobial agents. (2001) (120)
- Comparative Evaluation of Etest and Sensititre YeastOne Panels against the Clinical and Laboratory Standards Institute M27-A2 Reference Broth Microdilution Method for Testing Candida Susceptibility to Seven Antifungal Agents (2007) (119)
- Relationship of the Glyoxylate Pathway to the Pathogenesis of Cryptococcus neoformans (2002) (116)
- Fungal peritonitis in patients on continuous ambulatory peritoneal dialysis. (1983) (115)
- Separation of chromosomes of Cryptococcus neoformans by pulsed field gel electrophoresis (1989) (114)
- Identification of Cryptococcus neoformans Temperature-Regulated Genes with a Genomic-DNA Microarray (2004) (114)
- The Calcineurin Target, Crz1, Functions in Azole Tolerance but Is Not Required for Virulence of Candida albicans (2004) (114)
- Role of Alternative Oxidase Gene in Pathogenesis of Cryptococcus neoformans (2003) (112)
- Antifungal Activities of Antineoplastic Agents:Saccharomyces cerevisiae as a Model System To Study Drug Action (1999) (111)
- Mating-Type-Specific and Nonspecific PAK Kinases Play Shared and Divergent Roles in Cryptococcus neoformans (2002) (111)
- Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans (2017) (109)
- The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries (2022) (109)
- Cryptococcus neoformans: the yeast that likes it hot. (2006) (108)
- Cryptococcus: from human pathogen to model yeast. (2010) (107)
- Prospective Aspergillus Galactomannan Antigen Testing in Pediatric Hematopoietic Stem Cell Transplant Recipients (2007) (107)
- Trehalose 6‐phosphate phosphatase is required for cell wall integrity and fungal virulence but not trehalose biosynthesis in the human fungal pathogen Aspergillus fumigatus (2010) (106)
- A meta-analysis of medical versus surgical therapy for Candida endocarditis. (2005) (105)
- β-D-glucan Surveillance with Preemptive Anidulafungin for Invasive Candidiasis in Intensive Care Unit Patients: A Randomized Pilot Study (2012) (105)
- The Cryptococcus neoformans Transcriptome at the Site of Human Meningitis (2014) (104)
- Drug resistance in Cryptococcus neoformans. (1999) (104)
- Formation of Azole-Resistant Candida albicans by Mutation of Sterol 14-Demethylase P450 (1999) (103)
- The Cryptococcus neoformans Catalase Gene Family and Its Role in Antioxidant Defense (2006) (103)
- Calcineurin Inhibition or Mutation Enhances Cell Wall Inhibitors against Aspergillus fumigatus (2007) (103)
- Cryptococcus neoformans: a sugar-coated killer with designer genes. (2005) (103)
- Penetration of imidazoles and triazoles into cerebrospinal fluid of rabbits. (1985) (102)
- Cryptococcus neoformans Mitochondrial Superoxide Dismutase: an Essential Link between Antioxidant Function and High-Temperature Growth (2005) (101)
- Ecology of Cryptococcus neoformans (1998) (97)
- Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators (2017) (96)
- The (1,3)β-d-Glucan Test as an Aid to Early Diagnosis of Invasive Fungal Infections following Lung Transplantation (2010) (95)
- Signal transduction pathways regulating differentiation and pathogenicity of Cryptococcus neoformans. (1998) (95)
- Sequential prophylactic oral and empiric once-daily parenteral antibiotics for neutropenia and fever after high-dose chemotherapy and autologous bone marrow support. (1994) (94)
- ECMM/ISHAM recommendations for clinical management of COVID‐19 associated mucormycosis in low‐ and middle‐income countries (2021) (94)
- Phase 1b Study of New Posaconazole Tablet for Prevention of Invasive Fungal Infections in High-Risk Patients with Neutropenia (2014) (94)
- Cryptococcus neoformans Requires a Functional Glycolytic Pathway for Disease but Not Persistence in the Host (2011) (94)
- Scedosporium prolificans Osteomyelitis in an Immunocompetent Child Treated with Voriconazole and Caspofungin, as Well as Locally Applied Polyhexamethylene Biguanide (2003) (93)
- Antifungal resistance trends towards the year 2000. Implications for therapy and new approaches. (1997) (92)
- The impact of the host on fungal infections. (2012) (92)
- Topoisomerase I is essential in Cryptococcus neoformans: role In pathobiology and as an antifungal target. (1999) (90)
- Fungal diagnosis: how do we do it and can we do better? (2013) (89)
- Treatment of lymphocutaneous and visceral sporotrichosis with fluconazole. (1996) (88)
- Identification and characterization of the Cryptococcus neoformans phosphomannose isomerase‐encoding gene, MAN1, and its impact on pathogenicity (2001) (87)
- The Trehalose Synthesis Pathway Is an Integral Part of the Virulence Composite for Cryptococcus gattii (2009) (86)
- In Vitro Antifungal Activities of a Series of Dication-Substituted Carbazoles, Furans, and Benzimidazoles (1998) (85)
- Genetic variation in the dectin-1/CARD9 recognition pathway and susceptibility to candidemia. (2011) (85)
- Macrophage-mediated fungistasis in vitro: requirements for intracellular and extracellular cytotoxicity. (1986) (83)
- Posaconazole as Salvage Therapy in Patients With Invasive Fungal Infections After Solid Organ Transplant (2008) (83)
- Effects of antifungal agents and gamma interferon on macrophage cytotoxicity for fungi and tumor cells. (1987) (83)
- In Vitro Analyses, Animal Models, and 60 Clinical Cases of Invasive Aspergillus terreus Infection (2004) (82)
- Risk factors for mortality in patients with mucormycosis. (2012) (82)
- Fluconazole and Candida krusei fungemia. (1991) (82)
- First Reported Case of Cryptococcus gattii in the Southeastern USA: Implications for Travel-Associated Acquisition of an Emerging Pathogen (2009) (82)
- Peroxisome Function Regulates Growth on Glucose in the Basidiomycete Fungus Cryptococcus neoformans (2006) (81)
- Cytokine gene polymorphisms and the outcome of invasive candidiasis: a prospective cohort study. (2012) (81)
- Cryptococcus neoformans: virulence and host defences. (1998) (80)
- When primary antifungal therapy fails. (2008) (80)
- Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia (2014) (80)
- Diagnosis and treatment of oropharyngeal candidiasis in patients infected with HIV: a critical reassessment. (1999) (79)
- Early treatment of candidemia in adults: a review. (2011) (79)
- Identification and Characterization of an SKN7 Homologue in Cryptococcus neoformans (2005) (79)
- Fungal virulence genes as targets for antifungal chemotherapy (1996) (79)
- Candida glabrata fungemia in transplant patients receiving voriconazole after fluconazole. (2005) (79)
- Use of Antifungal Combination Therapy: Agents, Order, and Timing (2010) (79)
- The Hsp90 Co-Chaperone Sgt1 Governs Candida albicans Morphogenesis and Drug Resistance (2012) (76)
- The Emergence of COVID-19 Associated Mucormycosis: Analysis of Cases From 18 Countries (2021) (76)
- Tracing Genetic Exchange and Biogeography of Cryptococcus neoformans var. grubii at the Global Population Level (2017) (74)
- Production of the hexitol D-mannitol by Cryptococcus neoformans in vitro and in rabbits with experimental meningitis (1990) (74)
- Anastomotic infections in lung transplant recipients. (2000) (73)
- Caspofungin: first approved agent in a new class of antifungals (2003) (72)
- Brain Inositol Is a Novel Stimulator for Promoting Cryptococcus Penetration of the Blood-Brain Barrier (2013) (71)
- Fatal, disseminated Acremonium strictum infection in a neutropenic host (1996) (71)
- Infection and cyclosporine. (1989) (71)
- Teaching old drugs new tricks: reincarnating immunosuppressants as antifungal drugs. (2003) (71)
- Cryptococcus neoformans phospholipase B1 activates host cell Rac1 for traversal across the blood–brain barrier (2012) (70)
- Outcome of lung transplantation in patients with mycetomas. (2002) (70)
- Intracellular Action of a Secreted Peptide Required for Fungal Virulence. (2016) (69)
- Association of plasma levels of human immunodeficiency virus type 1 RNA and oropharyngeal Candida colonization. (1999) (69)
- Erratum: NIAID mycoses study group multicenter trial of oral itraconazole therapy for invasive aspergillosis (American Journal of Medicine (August 1994) 97 (135-144)) (1994) (68)
- Molds: hyalohyphomycosis, phaeohyphomycosis, and zygomycosis. (2009) (67)
- Cryptococcus neoformans Differential Gene Expression Detected In Vitro and In Vivo with Green Fluorescent Protein (1999) (67)
- Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development (2017) (67)
- Phylogenomic analysis of non-ribosomal peptide synthetases in the genus Aspergillus. (2006) (67)
- In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus (2018) (66)
- Cryptococcus gattii Virulence Composite: Candidate Genes Revealed by Microarray Analysis of High and Less Virulent Vancouver Island Outbreak Strains (2011) (66)
- Dominant selection system for use in Cryptococcus neoformans. (1996) (66)
- Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients (2011) (65)
- Core Recommendations for Antifungal Stewardship: A Statement of the Mycoses Study Group Education and Research Consortium. (2020) (64)
- Aspergillus fumigatus Empyema, Arthritis, and Calcaneal Osteomyelitis in a Lung Transplant Patient Successfully Treated with Posaconazole (2004) (63)
- Cytochrome c peroxidase contributes to the antioxidant defense of Cryptococcus neoformans. (2005) (62)
- CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival (2016) (62)
- Scedosporium Species Infections and Treatments (2003) (61)
- Evaluation of a digital microfluidic real-time PCR platform to detect DNA of Candida albicans in blood (2012) (61)
- Invasive Fungal Infection after Lung Transplantation: Epidemiology in the Setting of Antifungal Prophylaxis. (2019) (60)
- Evaluation and management of Fungal infections in Immunocompromised patients (2005) (60)
- Candidal anastomotic infection in lung transplant recipients: successful treatment with a combination of systemic and inhaled antifungal agents. (1998) (59)
- Survival Defects of Cryptococcus neoformans Mutants Exposed to Human Cerebrospinal Fluid Result in Attenuated Virulence in an Experimental Model of Meningitis (2010) (59)
- In Vitro Interactions between Antifungals and Immunosuppressants against Aspergillus fumigatus Isolates from Transplant and Nontransplant Patients (2004) (59)
- Microevolution of Serial Clinical Isolates of Cryptococcus neoformans var. grubii and C. gattii (2017) (59)
- “Is there an emerging need for new antifungals?” (2016) (59)
- Posaconazole Exhibits In Vitro and In Vivo Synergistic Antifungal Activity with Caspofungin or FK506 against Candida albicans (2013) (59)
- Soft‐Tissue Fungal Infections: Surgical Management of 12 Immunocompromised Patients (1996) (58)
- Surfactant Protein D Increases Phagocytosis of Hypocapsular Cryptococcus neoformans by Murine Macrophages and Enhances Fungal Survival (2009) (58)
- Comparison of In Vitro Activities of Camptothecin and Nitidine Derivatives against Fungal and Cancer Cells (1999) (58)
- Cost of Invasive Fungal Infections in the Era of New Diagnostics and Expanded Treatment Options (2012) (58)
- Live Imaging of Host-Parasite Interactions in a Zebrafish Infection Model Reveals Cryptococcal Determinants of Virulence and Central Nervous System Invasion (2015) (57)
- The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections (2015) (56)
- Cryptococcus neoformans mitochondrial genomes from serotype A and D strains do not influence virulence (2004) (55)
- Non‐comparative evaluation of the safety of aerosolized amphotericin B lipid complex in patients undergoing allogeneic hematopoietic stem cell transplantation (2006) (54)
- Liposomal amphotericin B: clinical experience and perspectives (2005) (54)
- Antisense repression in Cryptococcus neoformans as a laboratory tool and potential antifungal strategy. (2002) (54)
- Effects of cyclosporine in experimental cryptococcal meningitis (1985) (54)
- Recent advances in the epidemiology, prevention, diagnosis, and treatment of fungal pneumonia (2002) (53)
- Fatal Scopulariopsis brevicaulis infection in a paediatric stem-cell transplant patient treated with voriconazole and caspofungin and a review of Scopulariopsis infections in immunocompromised patients. (2004) (53)
- Value of an inhalational model of invasive aspergillosis. (2004) (53)
- Microfluidic platform versus conventional real-time polymerase chain reaction for the detection of Mycoplasma pneumoniae in respiratory specimens. (2010) (53)
- Alopecia Associated with Fluconazole Therapy (1995) (53)
- Is it time to abandon the use of amphotericin B bladder irrigation? (2005) (53)
- Update on epidemiology of and preventive strategies for invasive fungal infections in cancer patients. (2014) (53)
- Oropharyngeal yeast flora and fluconazole resistance in HIV‐infected patientsreceiving long‐term continuous versus intermitent fluconazole therapy (1996) (53)
- Deletion of Cryptococcus neoformans AIF Ortholog Promotes Chromosome Aneuploidy and Fluconazole-Resistance in a Metacaspase-Independent Manner (2011) (52)
- Comparative analyses of clinical and environmental populations of Cryptococcus neoformans in Botswana (2015) (51)
- The actin gene from Cryptococcus neoformans: structure and phylogenetic analysis. (1995) (51)
- Cost-effectiveness of posaconazole versus fluconazole or itraconazole in the prevention of invasive fungal infections among neutropenic patients in the United States. (2009) (50)
- Amphotericin B lipid complex in the treatment of experimental cryptococcal meningitis and disseminated candidosis. (1994) (50)
- The war on cryptococcosis: A Review of the antifungal arsenal (2018) (50)
- Disseminated Cryptococcosis With Brain Involvement in Patients With Chronic Lymphoid Malignancies on Ibrutinib (2017) (49)
- A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution. (2003) (48)
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- A randomized, double-blind, placebo-controlled clinical trial of fluconazole as early empiric treatment of coccidioidomycosis pneumonia (Valley Fever) in adults presenting with community-acquired pneumonia in endemic areas (FLEET-Valley Fever) (2021) (2)
- Conventional Antifungals for Invasive Infections Delivered by Unconventional Methods; Aerosols, Irrigants, Directed Injections and Impregnated Cement (2022) (2)
- Macrophage oxidation of L-arginine is linked to fungistatic capability. (1990) (2)
- Management of the immunocompromised patient: impact of fungal infections. Introduction. (1991) (2)
- What Can the Clinical Mycology Laboratory Do for Clinicians Today and Tomorrow? (2017) (2)
- Role of Classic Dimorphic Pathogens in Contemporary Mycoses (1994) (2)
- Management of phaeohyphomycosis (2019) (2)
- Genomic characterization of recurrent mold infections in thoracic transplant recipients (2018) (2)
- TREATMENT OF CRYPTOCOCCOSIS (1979) (2)
- Pharmacokinetics and Pharmacodynamics of Fluconazole For (2013) (2)
- Potential Value of Cefoperazone in Bacterial Meningitis: Experimental Studies (2012) (2)
- Correction to Molecular Umbrella–Amphotericin B Conjugates (2015) (2)
- Cost-Effectiveness of Posaconazole Versus Standard Azole Therapy in the Prevention of Invasive Fungal Infections among High-Risk Neutropenic Patients in the U.S. (2006) (2)
- Autophagy is redundant for the host defense against systemic Candida albicans infections (2013) (1)
- Reply to Day et al. (2021) (1)
- Current Controversies in the Treatment of Fungal Infections (2011) (1)
- Clinical mycology today: A synopsis of the mycoses study group education and research consortium (MSGERC) second biennial meeting, September 27-30, 2018, Big Sky, Montana, a proposed global research agenda. (2020) (1)
- Reply to Argüelles (2017) (1)
- Rational Use of Antifungals for Invasive Fungal Infections in the Institutional Setting (2004) (1)
- In vitro and in vivo characterisation of isolates of cryptococcus neoformans causing meningitis in hiv infected and uninfected patients in vietnam (2017) (1)
- A link between urease and polyamine metabolism in Cryptococcus neoformans. (2021) (1)
- QTc Prolongation in Patients Receiving Triazoles and Amiodarone (2017) (1)
- Invasive Fungal Disease in the Transplant Population: An Overview (2019) (1)
- A Case of Cryptococcus gattii in Western Florida: An Aggressive Pathogen in an Immunocompetent Host (2015) (1)
- 1 IN VITRO AND IN VIVO CHARACTERISATION OF ISOLATES OF CRYPTOCOCCUS 1 NEOFORMANS CAUSING MENINGITIS IN HIV INFECTED AND UNINFECTED PATIENTS 2 IN VIETNAM 3 4 (2017) (1)
- Clinical mycology today: A synopsis of the mycoses study group education and research consortium (MSGERC) second biennial meeting, September 27-30, 2018, Big Sky, Montana, a proposed global research agenda. (2020) (1)
- Use of polyenes for prophylaxis for invasive fungal infections (2006) (1)
- Genomics of Cryptococcus neoformans (2018) (1)
- The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections (2015) (1)
- Management of mucormycoses (2019) (1)
- Transcriptional Profiles Elucidate Differential Host Responses to Infection with Cryptococcus neoformans and Cryptococcus gattii (2022) (1)
- A Novel Antifungal Strategy (2010) (1)
- Outcomes and Health Care Resource Utilization of Adult Bacterial Meningitis in the United States. (2020) (1)
- Invasive mycoses: evolving challenges and opportunities in antifungal therapy. Introduction. (2012) (1)
- Therapy of Cryptococcosis (1998) (1)
- Antifungal therapy: current concepts and evidence-based management (2013) (1)
- Drug Spotlight: The new antifungals—safe and effective (2005) (1)
- Trends in natural resources degradation in the Kagera basin of Tanzania. (2011) (1)
- Pulmonary fungal infections : Making the diagnosis (2007) (1)
- Black mold takes hold and story told (2020) (1)
- Posaconazole: A Viewpoint by John R. Perfect (2005) (1)
- Toll like receptor 1 polymorphisms and susceptibility to invasive candidiasis (2009) (1)
- Chapter 48 – Fungal Infections of the Central Nervous System (2008) (1)
- Posaconazole (POS) Safety and Efficacy in Elderly Patients with Invasive Fungal Infections (IFIs) (2004) (0)
- Cryptococcusneoformans : theyeast that likes it hot (2006) (0)
- Management of cryptococcosis (2019) (0)
- Infectious Diseases: Where is the Passion, Worth, and Fun (2016) (0)
- Efficacy of APX2039 in a Rabbit Model of Cryptococcal Meningitis (2022) (0)
- Cryptococcus neoformans Inhibitors FK 506 and L-685 , 818 against Acetate ( L-743 , 873 ) with Calcineurin Pneumocandin MK-0991 / Caspofungin , Fluconazole , and the 1 Bafilomycin A Synergistic Antifungal Activities of (1999) (0)
- INVASIVE FUNGAL infections (2007) (0)
- Procedes de traitement d'infections microbiennes (1996) (0)
- Cryptococcosis in the Normal Host (2008) (0)
- Surfactant Protein D enhances phagocytosis of Cryptococcus neoformans hypocapsular strain cap59Δ by murine macrophages (2008) (0)
- Cryptococcus Species Induction in Human-Pathogenic Nitrogen Source-Dependent Capsule (2014) (0)
- Prevention of Human Infection (1998) (0)
- Adaptive Immunity to Fungi (2014) (0)
- Vitamin D deficiency in HIV-infected South Africans: Common, and not associated with susceptibility, immune response, or outcome in HIV-associated cryptococcal meningitis (2014) (0)
- Contributors (2015) (0)
- Effectiveness of posaconazole vs fluconazole as antifungal prophylaxis in hematology-oncology patients at Duke University Hospital (DUH) 2004-2010 (2010) (0)
- Management of Zygomycosis (2009) (0)
- Cryptococcosis: New IDSA Quidelines for Management (2008) (0)
- TOLERANCE IN VIRIDANS STREPTOCOCCI EXERTS A MAJOR INFLUENCE ON EFFICACY OF PENICILLIN INVIVO (1982) (0)
- A Chronological History of the International Conference on Cryptococcus and Cryptococcosis (ICCC), an Invaluable Forum for Growth of the Cryptococcal Research Field and Clinical Practice (2011) (0)
- IN VITRO AND IN VIVO CHARACTERISATION OF ISOLATES OF CRYPTOCOCCUS 1 NEOFORMANS CAUSING MENINGITIS IN HIV INFECTED AND UNINFECTED PATIENTS (2017) (0)
- Cryptococcus neoformans Controls Virulence of the Fungal Pathogen Cyclic AMP-Dependent Protein Kinase (2001) (0)
- Copy number variation contributes to cryptic genetic variation in outbreak lineages of Cryptococcus gattii from the North American Pacific Northwest (2016) (0)
- Evaluation of a digital microfluidic real-time PCR platform to detect DNA of Candida albicans in blood (2012) (0)
- Tourism Implications of Cryptococcus gattii in the Southeastern USA (2011) (0)
- Correction: Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype (2019) (0)
- Hodgkinʼs Disease Masquerading as Primary Scerosing Cholangitis: 937 (2008) (0)
- Genetic Susceptibility to Fungal Infections: What is in the Genes? (2016) (0)
- Chapter 46 – Fungal Infections of the Central Nervous System (2014) (0)
- Management of endemic mycoses (2019) (0)
- Curious Crosses: Injection-Induced Lesions. (2017) (0)
- A method of controlling infectious diseases using dicationic bis-benzimidazole (1996) (0)
- Emerging Antifungal Resistance: Mechanisms and Epidemiology (2006) (0)
- 717. Susceptibility to Cryptococcosis in Bruton's Tyrosine Kinase Knockout Model (2021) (0)
- Fungal Infections of the Central Nervous System (2021) (0)
- Calcineurin Controls Growth, Morphology, and Pathogenicity in <italic toggle='yes'>Aspergillus fumigatus</italic> (2006) (0)
- Mediastinitis complicating cellulitis of the head and neck. (1980) (0)
- CCeftaroline Fosamil in the Treatment of Experimental Meningitis Caused by Methicillin-Resistant Staphylococcus aureus (2020) (0)
- Incidence of invasive fungal infections following the use of prophylactic aerosolized amphotericin B lipid complex in lung transplant recipients (2012) (0)
- Book Review Fungal Infections in the Immunocompromised Patient (Infectious Disease and Therapy. Vol. 34.). Edited by John R. Wingard and Elias J. Anaissie. 675 pp., illustrated. Boca Raton, Fla., Taylor & Francis, 2005. $199.95. 0-8247-5428-X (2006) (0)
- 168. Efficacy of the Novel gwt1 Inhibitor APX2039 in a Rabbit Model of cryptococcus Meningitis (2020) (0)
- Ceftaroline fosamil in the treatment of experimental meningitis caused by methicillin-resistant Staphylococcus aureus (2020) (0)
- Cryptococcus neoformans: A Molecular Model for the Study of Fungal Pathogenesis and Drug Discovery in the Genomic Era (2002) (0)
- Candida Endophthalmitis: Who Is Looking? (2007) (0)
- The impact of caspase-12 on susceptibility to candidemia (2011) (0)
- Macrophage oxidation of smallcap˜L-arginine is linked to fungistatic capability. (1990) (0)
- The Phenomenon of Adventitious Sporulation (1998) (0)
- Faculty Opinions recommendation of A new arenavirus in a cluster of fatal transplant-associated diseases. (2008) (0)
- 115 Mortality rates for breakthrough invasive fungal infections in a multicenter trial of posaconazole vs standard azole prophylaxis (2006) (0)
- A multicenter, randomized trial of posaconazole (POS) vs fluconazole (FLU) or itraconazole (ITZ) for prophylaxis of invasive fungal infections (IFIs) in neutropenic patients with acute myelogenous leukemia (AML) or myelodysplastic syndrome (MDS) receiving intensive chemotherapy (2006) (0)
- Differential Effects of Inhibiting Chitin and 1,3- (cid:2) - D -Glucan Synthesis in Ras and Calcineurin Mutants of Aspergillus fumigatus (cid:1) (2009) (0)
- Population Pharmacodynamics of Amphotericin B Deoxycholate for Disseminated Infection Caused by <italic toggle='yes'>Talaromyces marneffei</italic> (2019) (0)
- Abstract 1384: Transposon mobility in serial isolates of Cryptococcus neoformans from patients with recurrent cryptococcal meningitis (2023) (0)
- CASE STUDIES IN SERIOUS FUNGAL INFECTIONS (0)
- Antifungal Pharmacokinetics and Pharmacodynamics Subject Collection Human Fungal Pathogens Pneumocystis (2014) (0)
- Trehalose-6-phosphate synthase-deletion in Cryptococcus neoformans elicits rapid innate fungal clearance from the lungs with early neutrophil accumulation (2019) (0)
- Future strategies for the treatment of cryptococcal meningoencephalitis in pediatric patients (2014) (0)
- 2015 Anü fungal Drug Development Summit Speakers (2015) (0)
- Dosing Voriconazole in Obese Patients (2017) (0)
- Reply to Baden and Marty (2007) (0)
- Emergence of the Molds 3 Specific risk factors in solid organ transplantation (2017) (0)
- Another case of cryptococcal meningitis in a person without HIV who injects drugs: A possible risk factor in need of further investigation (2022) (0)
- Tuberculous Pseudoaneurysm of the Thoracoabdominal Aorta: Case and Review (2000) (0)
- 2112. Voriconazole for Primary Prophylaxis: A Decade of Trends and Outcomes (2019) (0)
- Related Species Aspergillus fumigatus Subject Collection Human Fungal Pathogens Pneumocystis (2014) (0)
- Reply to Wise (2005) (0)
- Comprar Antifungal Therapy | John R. Perfect | 9780849387876 | Informa Healthcare (2009) (0)
- 605. Efficacy and pharmacokinetics-pharmacodynamics of ATI-2307 in a rabbit model of cryptococcal meningoencephalitis (2022) (0)
- Antifungal therapy (1988) (0)
- Antifungal Therapy, Second Edition (2019) (0)
- Antifungal therapy for infections of the compromised host. (1990) (0)
- Identification of Host-Derived Biomarker Signatures in Cryptococcal Infection (2016) (0)
- Hospital-Acquired Infections (1985) (0)
- Pharmacology and Cancer Biology, 2 Microbiology And (0)
- Cryptococcosis...What Do the Sugar-Coated Yeasts Have to Say About It (2014) (0)
- The Economic Costs to US Hospitals of Invasive Fungal Infections in Hematopoietic Stem Cell and Bone Marrow Transplant Patients (2009) (0)
- OUR CURRENT UNDERSTANDING OF THERAPIES FOR INVASIVE FUNGAL INFECTIONS (2004) (0)
- Inkjet Printing of Amphotericin B onto Biodegradable Microneedles Using Piezoelectric Inkjet Printing (2013) (0)
- Cryptococcosis (2014) (0)
- Breakthrough Invasive Candidiasis in Patients on Micafungin (cid:1) † (2010) (0)
- What Can the Clinical Mycology Laboratory Do for Clinicians Today and Tomorrow? (2017) (0)
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What Schools Are Affiliated With John Robert Perfect?
John Robert Perfect is affiliated with the following schools:
