John Thomas Sharp

John Thomas Sharp's AcademicInfluence.com Rankings

John Thomas Sharp

Philosophy

#8230

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#11569

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#6649

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philosophy Degrees

John Thomas Sharp

Biology

#11105

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#14480

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Immunology

#710

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#732

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biology Degrees

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Philosophy
Biology

John Thomas Sharp's Degrees

Doctorate Medicine Harvard University
PhD Immunology Stanford University

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John Thomas Sharp's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. (2006) (1853)
Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: a randomized, placebo-controlled, 52-week trial. (2004) (1253)
Etanercept treatment of psoriatic arthritis: safety, efficacy, and effect on disease progression. (2004) (892)
Adalimumab for the treatment of patients with moderately to severely active psoriatic arthritis: results of a double-blind, randomized, placebo-controlled trial. (2005) (864)
Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Leflunomide Rheumatoid Arthritis Investigators Group. (1999) (765)
Two-year effects of alendronate on bone mineral density and vertebral fracture in patients receiving glucocorticoids: a randomized, double-blind, placebo-controlled extension trial. (2001) (525)
Methods of scoring the progression of radiologic changes in rheumatoid arthritis. Correlation of radiologic, clinical and laboratory abnormalities. (1971) (493)
Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: a twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial. (2008) (489)
How many joints in the hands and wrists should be included in a score of radiologic abnormalities used to assess rheumatoid arthritis? (1985) (428)
Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. II. Evidence that the disease is a disseminated immunologic response to exogenous antigen. (1960) (325)
Radiographic outcome of recent-onset rheumatoid arthritis: a 19-year study of radiographic progression. (1998) (318)
Two-year, blinded, randomized, controlled trial of treatment of active rheumatoid arthritis with leflunomide compared with methotrexate. Utilization of Leflunomide in the Treatment of Rheumatoid Arthritis Trial Investigator Group. (2001) (301)
Adalimumab for long-term treatment of psoriatic arthritis: forty-eight week data from the adalimumab effectiveness in psoriatic arthritis trial. (2007) (295)
Treatment with leflunomide slows radiographic progression of rheumatoid arthritis: results from three randomized controlled trials of leflunomide in patients with active rheumatoid arthritis. Leflunomide Rheumatoid Arthritis Investigators Group. (2000) (293)
Gold salts in the treatment of rheumatoid arthritis. A double-blind study. (2020) (284)
Adalimumab for long-term treatment of psoriatic arthritis: 2-year data from the Adalimumab Effectiveness in Psoriatic Arthritis Trial (ADEPT) (2008) (265)
STUDIES OF ARTHRITIS AND OTHER LESIONS INDUCED IN RATS BY INJECTION OF MYCOBACTERIAL ADJUVANT (1960) (260)
Continued inhibition of radiographic progression in patients with psoriatic arthritis following 2 years of treatment with etanercept. (2006) (228)
The progression of erosion and joint space narrowing scores in rheumatoid arthritis during the first twenty-five years of disease. (1991) (210)
Assessment of radiologic progression in rheumatoid arthritis. A randomized, controlled trial. (1986) (167)
Psoriatic arthritis imaging: a review of scoring methods (2005) (161)
POLYARTHRITIS, POLYARTERITIS AND HEPATITIS B (1976) (158)
How to report radiographic data in randomized clinical trials in rheumatoid arthritis: guidelines from a roundtable discussion. (2002) (153)
Transverse myelopathy in systemic lupus erythematosus. Report of three cases and review of the literature. (1975) (144)
Rheumatoid arthritis joint progression in sustained remission is determined by disease activity levels preceding the period of radiographic assessment. (2009) (135)
Reproducibility of multiple-observer scoring of radiologic abnormalities in the hands and wrists of patients with rheumatoid arthritis. (1985) (129)
Relationship of the clinical course of systemic lupus erythematosus to the presence of circulating lymphocytotoxic antibodies. (1972) (114)
Less Radiographic Progression with Adalimumab Plus Methotrexate Versus Methotrexate Monotherapy Across the Spectrum of Clinical Response in Early Rheumatoid Arthritis (2009) (107)
Estimation of a numerical value for joint damage-related physical disability in rheumatoid arthritis clinical trials (2009) (106)
Computer-based methods for measuring joint space and estimating erosion volume in the finger and wrist joints of patients with rheumatoid arthritis. (2000) (94)
Antibodies to viral antigens in systemic lupus erythematosus. (1971) (93)
The etiology of rheumatoid arthritis. (1976) (89)
Repair of erosions in rheumatoid arthritis does occur. Results from 2 studies by the OMERACT Subcommittee on Healing of Erosions. (2003) (88)
OBSERVATIONS ON THE CLINICAL, CHEMICAL, AND SEROLOGICAL MANIFESTATIONS OF RHEUMATOID ARTHRITIS, BASED ON THE COURSE OF 154 CASES (1964) (84)
Clinical responses during gold therapy for rheumatoid arthritis. Changes in synovitis, radiologically detectable erosive lesions, serum proteins, and serologic abnormalities. (1982) (76)
Comparison of azathioprine, methotrexate, and the combination of the two in the treatment of rheumatoid arthritis. A forty-eight-week controlled clinical trial with radiologic outcome assessment. (1995) (72)
Evaluation of the preliminary definitions of minimal disease activity and remission in an early seropositive rheumatoid arthritis cohort. (2007) (70)
Radiographic data from recent randomized controlled trials in rheumatoid arthritis: what have we learned? (2003) (68)
Pulse methotrexate therapy in rheumatoid arthritis. A controlled prospective roentgenographic study. (1987) (68)
THE ROLE OF HIGH ELECTROLYTE CONCENTRATION IN THE PRODUCTION AND GROWTH OF L FORMS OF BACTERIA, (1956) (65)
Variability of precision in scoring radiographic abnormalities in rheumatoid arthritis by experienced readers. (2004) (64)
Radiologic assessment as an outcome measure in rheumatoid arthritis. (1989) (64)
Denosumab prevents metacarpal shaft cortical bone loss in patients with erosive rheumatoid arthritis (2010) (62)
Double-blind study of cyclophosphamide in rheumatoid arthritis. (1973) (56)
The "normal" sacroiliac joint. Analysis of 88 sacroiliac roentgenograms. (1967) (55)
Effect of plasma exchange on circulating immune complexes and antibody formation in patients treated with cyclophosphamide and prednisone. (1977) (54)
Comparison of two dosage schedules of gold salts in the treatment of rheumatoid arthritis. Relationship of serum gold levels to therapeutic response. (1977) (54)
L Colonies from hemolytic streptocci: new technic in the study of L forms of bacteria. (1954) (50)
Association of tumor necrosis factor alpha polymorphism, but not the shared epitope, with increased radiographic progression in a seropositive rheumatoid arthritis inception cohort. (2006) (49)
Ranitidine protects against gastroduodenal mucosal damage associated with chronic aspirin therapy. (1987) (49)
EXAMINATION OF THE L FORMS OF GROUP A STREPTOCOCCI FOR THE GROUP-SPECIFIC POLYSACCHARIDE AND M PROTEIN (1957) (49)
HLA-DRB1 genes and disease severity in rheumatoid arthritis. The MIRA Trial Group. Minocycline in Rheumatoid Arthritis. (1996) (47)
Computer based methods for measurement of joint space width: update of an ongoing OMERACT project. (2007) (42)
Increased radiographic damage scores at the onset of seropositive rheumatoid arthritis in older patients are associated with osteoarthritis of the hands, but not with more rapid progression of damage. (2005) (41)
Assessment of radiographic abnormalities in rheumatoid arthritis: what have we accomplished and where should we go from here? (1995) (38)
Cell-mediated immunity in rheumatoid arthritis. (1977) (37)
A study of periselectivity in the thermal cyclisation reactions of diene-conjugated diazo compounds: 1,7-cyclisation as a route to 3H-1,2-diazepines and 1,5-cyclisation leading to new rearrangement reactions of 3H-pyrazoles (1984) (37)
Reduction of Aspirin‐Induced Gastroduodenal Mucosal Damage with Ranitidine (1986) (35)
5.18 – Seven-membered Rings with Two or More Heteroatoms (1984) (35)
Correlation of single time-point damage scores with observed progression of radiographic damage during the first 6 years of rheumatoid arthritis. (2003) (34)
Progression of radiographic joint erosion during low dose corticosteroid treatment of rheumatoid arthritis. (2000) (33)
Comparison of composite measures of disease activity in an early seropositive rheumatoid arthritis cohort (2007) (32)
Radiographic results from the Minocycline in Rheumatoid Arthritis (MIRA) Trial. (1997) (31)
Antiglobulins and glomerulonephritis. Classification of patients by the reactivity of their sera and renal tissue with aggregated and native human IgG. (1975) (30)
Expert agreement confirms that negative changes in hand and foot radiographs are a surrogate for repair in patients with rheumatoid arthritis (2007) (28)
Treatment of Rheumatoid Arthritis with Marine and Botanical Oils: An 18-Month, Randomized, and Double-Blind Trial (2014) (27)
Mycoplasmas and arthritis. (1970) (27)
Comparison of a computer based method and the classical manual method for radiographic joint space width assessment in hip osteoarthritis. (2002) (26)
Relationship between multicentric reticulohistiocytosis and tuberculosis. (1977) (25)
Preliminary criteria for remission in rheumatoid arthritis. (1982) (25)
OMERACT workshop: repair of structural damage in rheumatoid arthritis. (2003) (24)
Severe Streptococcal Disease. Observations during an Epidemic occurring in Southern New England, 1958-1959. (1961) (24)
Treatment of Goodpasture syndrome with cyclophosphamide, prednisone and plasma exchange transfusions. (1976) (23)
The cytotoxicity of leukocytes and lymphocytes from patients with rheumatoid arthritis for synovial cells. (1976) (23)
Measurement of structural abnormalities in arthritis using radiographic images. (2004) (22)
Multicenter comparison of naproxen and indomethacin in rheumatoid arthritis. (1978) (22)
A search for viruses and mycoplasms in connective tissue diseases. (1973) (21)
An overview of radiographic analysis of joint damage in rheumatoid arthritis and its use in metaanalysis. (2000) (21)
Automated measurement of joint space width in small joints of patients with rheumatoid arthritis. (2008) (20)
Measurement of joint space width and erosion size. (2005) (20)
Studies on acellular bovine glomeruli. Isolation, chemical composition, and demonstration of collagen with an unusual hydroxylysine: hydroxyproline ratio. (1967) (19)
The role of myco-plasmas and L forms of bacteria in disease. (1970) (19)
A 12-month, multicenter, prospective, open-label trial of radiographic analysis of disease progression in osteoarthritis of the knee or hip in patients receiving celecoxib. (2002) (19)
Immune response of patients with rheumatoid arthritis during cyclophosphamide treatment. (1973) (18)
Classifying structural joint damage in rheumatoid arthritis as progressive or nonprogressive using a composite definition of joint radiographic change: a preliminary proposal. (2004) (18)
Infectious arthritis. (1979) (17)
Patient retention and hand-wrist radiograph progression of rheumatoid arthritis during a 3-year prospective study that prohibited disease modifying antirheumatic drugs. (2004) (17)
Scoring radiographic abnormalities in rheumatoid arthritis. (1996) (17)
Evidence for 1,2-ketocarbenes in thermolysis of sodium o-halogenophenoxides and for benzothiirens in thermolysis of sodium o-bromobenzenethiolates (1974) (17)
Kinetic Modeling of Contrast-Enhanced MRI: An Automated Technique for Assessing Inflammation in the Rheumatoid Arthritis Wrist (2007) (17)
The reactions of 2-alkynylbenzaldehydes with hydrazides: a route to isoquinoline N-imines (1980) (17)
Cell-mediated immunity in systemic lupus erythematosus. (1977) (16)
The synthesis of 1H- and 5H-thieno[1,2]diazepines by the electrocyclisation of α-(2-alkenylthienyl)diazoalkanes, and some observations on their photochemical reactivity and ring inversion (1980) (16)
Clinical studies on gonococcal arthritis and reiter's syndrome and measurement of gonococcal and bedsonia antibodies (1968) (16)
THE MYCOPLASMATACEAE (PPLO) AS CAUSES OF JOINT INFECTIONS. (1964) (16)
Adalimumab treatment effects on radiographic progression of joint disease in patients with psoriatic arthritis: Results from ADEPT (2005) (16)
Cyclisation of α-(o-alkenylaryl)diazoalkanes: a route to 2,3-benzodiazepines via a novel 1,7-electrocyclic ring closure (1973) (15)
Arthritis with nodules following ankylosing spondylitis. (1968) (15)
Replication of Rubella, Newcastle Disease, and Vesicular Stomatitis Viruses in Cultured Rheumatoid Synovial Cells 1 (1971) (14)
Steric effects in the reactions of αβ-unsaturated ketonep-tolylsulphonylhydrazones: a route to 1,2-benzodiazepines via 1,7-ring closure of 1,1-diaryl-3-diazoalkenes (1975) (14)
An efficient general route to furo-, pyrido- and thieno-[d][2]benzazepines via Pd0 catalysed cross coupling reactions and nitrile ylide cyclisations (1994) (14)
The generation and reactions of C,N-dianions of aromatic tosylhydrazones; ortho-N-dilithiated benzophenone tosylhydrazone (1986) (14)
The synthesis of 3H-1,2-diazepines by the base-induced elimination of toluene-p-sulphinic acid from 3,4-dihydro-2-tosyl-1,2-diazepines, and some observations on sigmatropic hydrogen shifts in the 3H-1,2-diazepine system (1979) (14)
Radiological progression in rheumatoid arthritis: how many patients are required in a treatment trial to test disease modification? (1993) (14)
Repair in rheumatoid arthritis, current status. Report of a workshop at OMERACT 8. (2007) (13)
Aspirin and delayed type hypersensitivity. (1977) (13)
Classifying radiographic progression status in early rheumatoid arthritis patients using propensity scores to adjust for baseline differences (2007) (13)
Equivalent Responses to Disease-modifying Antirheumatic Drugs Initiated at Any Time During the First 15 Months After Symptom Onset in Patients with Seropositive Rheumatoid Arthritis (2010) (12)
Nitrile Ylides and Nitrile Imines (2003) (12)
Electrocyclic aromatic substitution by the diazo group. Part 2. Ring size effects on the cyclisation of 1-aryl-3-diazoalkenes: a new rearrangement of 3H-pyrazoles to 3H-1,2-benzodiazepines (1979) (12)
Scoring radiographic abnormalities in rheumatoid arthritis. (1996) (12)
The adrenal cortex in rheumatic disease; pathologic study with special reference to effects of cortisone and corticotropin. (1951) (12)
Malposition of carpal bones in rheumatoid arthritis. (1972) (11)
Multiple Computer-based Methods of Measuring Joint Space Width Can Discriminate Between Treatment Arms in the COBRA Trial — Update of an Ongoing OMERACT Project (2009) (11)
Electrocyclic aromatic substitution by nitrile ylides to give 3H-2-benzazepines: substituent effects and mechanism (1992) (11)
1,7-Electrocyclisation and carbene reactions of o-alkenylaryldiazoalkanes: the effect of alkene configuration on the mode of reaction (1984) (10)
The effect of alkene configuration on the partitioning between the carbenic reactions and the 1,7-electrocyclisation of α-)o-alkenylaryl)diazoalkanes (1980) (10)
Photochemical reactions of 1H-2,3-benzodiazepines: valence isomerisation of a 1,2-diazabutadiene to a diazetine (1976) (10)
AMINO SUGARS IN L FORMS OF BACTERIA AND PLEUROPNEUMONIA-LIKE ORGANISMS (1963) (10)
The acylation of 5H-2,3-benzodiazepines (1982) (10)
CLINICAL AND LABORATORY STUDIES OF A DISTINCTIVE TYPE OF ARTHRITIS OBSERVED IN NEW GUINEA (1969) (10)
A note on three routes to benzyne: decomposition of diphenyliodonium acetate, nitrosation of N-phenylphosphylamidates, and deoxygenation of benzenediazotoluene-p-sulphonate N′-oxide (cupferron tosylate) by phosphorus trichloride (1975) (9)
Photolysis of 1H- and 5H-2,3-benzodiazepines (1972) (9)
Synthesis of 2-substituted 3,4-dihydro-1,2-diazepines by the reactions of unsaturated ketones with hydrazides (1982) (8)
The preparation of 3H-1,2-diazepine 2-oxides and their rearrangement to give 3-alkenyl-3H-pyrazole 2-oxides (1985) (8)
EXPERIMENTAL STREPTOCOCCAL INFECTIONS. I. PRODUCTION OF RENAL DISEASE IN THE WHITE MOUSE. (1964) (8)
MULTIPLE PERIPHERAL GANGRENE. (1965) (8)
CLINICAL AND LABORATORY STUDIES OF A DISTINCTIVE TYPE OF ARTHRITIS OBSERVED IN NEW GUINEA (1969) (8)
Asymmetric induction in the electrocyclisations of 1,3 dipolar intermediates: the 1.7 cyclisation of diene-conjugated diazo-compounds to give 1H-2,3-benzodiazepines (1994) (8)
The formation of arynes by reaction of potassium t-butoxide with aryl halides (1967) (7)
Reactions of diene-conjugated 1,3-dipolar intermediates: the formation of cyclopropa[c]isoquinolines from benzonitrile o-alkenylbenzyl ylides and their rearrangements to benzazepines (1992) (7)
Photochemical isomerisation of 3H-1,2-diazepines to 4,6a-dihydro[1,2]diazeto[1,4-a]pyrroles (1980) (7)
The sensitized sheep cell agglutination reaction in rheumatoid arthritis. (1956) (7)
The thermal and photochemical reactions of 3H-1, 2-diazepines : A new variation on the diazepine-pyrazole rearrangement (1976) (7)
Acylarylnitrosamines. Part III. Decomposition of 2,5-di-(N-nitrosoacetamido)-1,4-di-t-butylbenzene and related compounds (1971) (7)
Benzazepine formation by the 1.7 electrocyclisations of diene-conjugated nitrile ylides: studies on relative rates of cyclisation via intramolecular competition reactions (1995) (7)
Simple, convenient, and direct conversion of anilines and anilides into arynes (1972) (7)
A route to dihydro[2]benzooxepino[4,5-c]pyridines and dihydrothieno[d][2]benzooxepines via the 1.7-electrocyclisation of carbonyl ylides (1996) (6)
The acylation of 5H-2,3-benzodiazepines. Reactions of 4-phenyl-5H-2,3-benzodiazepine with acyl chlorides to give N-acylaminoisoquinolines and/or acylated dimers. X-Ray molecular structure of 5,14-diacetyl-4,5,8,9-tetrahydro-2,7-diphenyl-4,8-o-benzeno-3,9-imino-3H-3,5,6-benzotriazacycloundecine (1984) (6)
Novel reactions of diazonium salts: direct conversion of o- and p-chlorobenzenediazonium acetates into hydroxybenzenediazonium salts, of o-acetoxybenzenediazonium acetate into the carbene, 2-oxocyclohexa-3,5-dienylidene, and of o-thioacetoxybenzenediazonium acetate into 1,2,3-benzothiadiazole (1976) (6)
Reaction of phenyl radicals with dialkyl azodiformates: formation of, and nuclear magnetic resonance studies of conformational restrictions in, tetra-alkyl 1,4-diphenyltetra-azane-1,2,3,4-tetracarboxylates (1975) (6)
The acylation of 5H-2,3-benzodiazepines and 4H-thieno[2,3-d]- and 8H-thieno-[3,2-d]-[1,2]diazepines. Reactions with acid anhydrides and nucleophiles to give fused 7-substituted 1-acyl-1,2-diazepines (1984) (6)
Gonococcal infections and arthritis (1974) (6)
3H-1,2-diazepines via 3,4-dihydro-2-tosyl-1,2-diazepines (1975) (6)
Reactions of diene-conjugated 1,3-dipolar intermediates: a versatile and efficient route to dibenz[c,e]azepines via benzonitrile o-arylbenzyl ylides (1993) (6)
CARBOHYDRATE CONTAINING ANTIGEN FROM THE BACTERIAL AND L FORMS OF PROTEUS (1959) (6)
The fixation of complement by human sera and alcoholic extracts of human cardiac tissue. (1954) (6)
Asymmetric induction in the 1,7 ring closure of diene-conjugated diazo-compounds: a route to chiral 1H-2,3-benzodiazepines (1988) (6)
A simple, one-step, conversion of aniline into benzyne (1971) (5)
A new aromatic annelation process: reaction of aryl radicals with dimethyl acetylenedicarboxylate (1972) (5)
Reaction of diene-conjugated 1,3-dipolar intermediates: the formation of cycloprop[c]isoquinolines from benzonitrile o-alkenylbenzyl ylides and their rearrangements to 2-benzazepines (1984) (5)
Steric effects in the cyclisation of diazoalkenes: a new route to 1,2-benzodiazepines (1970) (5)
Cyclisation reactions of 1-aryl-3-diazoalkenes: a new rearrangement of 3H-pyrazoles to 3H-1,2-benzodiazepines (1975) (5)
Speculations on Why Early Treatment of Rheumatoid Arthritis Is Uniquely Effective (2008) (5)
A route to 1,4-prop[2]enoisoquinolines via the cyclisation of triene-conjugated nitrile ylides1 (1999) (5)
Electrocyclic aromatic substitution by the diazo group. Part 5. The reactions of α-(2-arylthienyl)diazoalkanes (1984) (5)
Reactions of triene-conjugated diazo-compounds: reaction paths from o-(1,3-dienyl)aryldiazomethanes to 3,8-methano-1,2-diazocines and to pyrrolo[2,1-a]phthalazines via intramolecular (3 + 2) and 1,1-cycloaddition reactions (2000) (5)
Use of benzyne promoters in the conversion of benzenediazonium acetate into benzyne (1974) (4)
Acylarylnitrosamines. Part VI. Anomalous reactions with 2,5-di-methylfuran: the formation of 2-benzyl-5-methylfurans and 3-acetyl-1-aryl-4-arylazo-5-methylpyrazoles (1972) (4)
Cyclisation reactions of diazoalkenes: 2,3-benzodiazepines from α-(o-alkenylaryl)diazoalkanes (1970) (4)
Duality of mechanism in the reaction of triethyl phosphite and carbon tetrachloride (1966) (4)
The cyclisation of benzonitrile 3,3-diarylallyl ylides to give 3H-2-benzazepines: substituent directive effects and mechanism (1987) (4)
Isolation of L Forms of Bartonella bacilliformis ∗ (1968) (4)
The preparation of some 1,7b-disubstituted cyclopropa[c]isoquinolines via nitrile ylide cyclisations and their rearrangement to 2-benzazepines and 4-alkenyl-1,4-dihydroisoquinolines (1998) (4)
Seven-membered ring compounds containing nitrogen in the ring (1991) (4)
1,7-Electrocyclic substitution by nitrile ylides: the effect on the reaction rate of the nature of the γ,δ-double bond and of aromatic substituents (1991) (4)
Infectious Agents in the Arthritides: Current Status (1971) (4)
Acid-catalysed cyclisation of αβ,γδ-unsaturated p-tolylsulphonylhydrazones to 3,4-dihydro-2-tolylsulphonyl-1,2-diazepines (1979) (4)
[2H] Labelling studies on the mechanism of electrocyclic aromatic substitution by the diazo-group (1981) (4)
Acylarylnitrosamines. Part IV. Aryne participation in decompositions of N-nitrosoacetanilide and its m- and p-t-butyl-, o-, m-, and p-chloro-derivatives in benzene (1971) (3)
In situ formation of arenediazonium salts and aryl radicals by aprotic nitrosation of 1,3-diaryltriazenes: dual halogen abstraction from bromotrichloromethane, and radical arylation of aromatic compounds (1977) (3)
An easy route to dibenz[c,e]azepines via nitrile ylide cyclisation: the electrocyclic equivalent of a Bischler–Napieralski reaction (1987) (3)
The Preparation of lsoquinoline-N-imines by the Reaction of 1-Acyl-2-(2′-oxoalkyl)-arenes with Hydrazides (1985) (3)
Interconversion of five- and seven-membered cyclic azo-compounds: a 1,3-azo-group migration studied by high-speed liquid chromotography (1974) (3)
Substituent directive effects in 1,2-benzodiazepine synthesis via electrocyclic aromatic substitution by the diazo-group: a rearrangement of 9- to 7-substituted 3H-1,2-benzodiazepines (1980) (3)
The photochemical reactions of α,β,γ,δ -unsaturated diazo compounds at low temperature (1984) (3)
Quantitative studies of homolytic hydrogen abstraction from aliphatic compounds: chain-transfer constants in the presence of styrene (1966) (3)
A route to 3H-1,2-diazepines by the 1,7-electrocyclisation of α,βγ,δ-unsaturated diazo-compounds (1983) (3)
Spin trapping by tetraphenylcyclopentadienone and 2,3-diarylindenones. New long-lived radicals and their relevance to benzyne promotion from benzenediazonium acetate (1975) (3)
Dinuclear iron carbonyl complexes of 3H-1,2-diazepines (1981) (3)
Magnetic resonance imaging in rheumatologic practice: low field or standard. (2006) (3)
Formation of di-iron hexacarbonyl complexes of 3H-1,2-diazepines and the effects of complexation on ring inversion and the rate of sigmatropic hydrogen migration (1984) (3)
L Colonies from Hemolytic Streptococci (1954) (3)
Synthetic aspects of free radical addition reactions. Part V. Alkylation of compounds containing activated methylene and methine groups (1966) (3)
Studies on bovine glomeruli. II. Localization of glomerular collagen. (1967) (3)
Acylarylnitrosamines. Part II. The formation of arynes in the anomalous decompositions of o-t-butyl- and 2,5-di-t-butyl-N-nitrosoacetanilide (1971) (3)
Adrenal cortex in rheumatic diseases, with special reference to the effects of cortisone and ACTH. (1951) (3)
On the formation of benzenediazonium chloride in Gomberg–Hey type reactions of diazonium salts with bromotrichloromethane, carbon tetrachloride, and chloroform. The solution of a long-standing mechanistic puzzle (1976) (3)
Conversion of 2,5-dimethylfuran in to 2-benzyl-5-methylfuran by N-nitrosoacetanilide: an unprecedented aromatic side-chain phenylation (1971) (3)
Reactions of triene-conjugated diazo-compounds containing thiophene (2002) (3)
Synthetic aspects of free-radical addition reactions. Part VI. The relative reactivities of ethyl malonate and related compounds towards oct-1-ene (1967) (2)
In-office imaging in the care of patients with rheumatoid arthritis (2005) (2)
Aromatic annelation by reaction of aryl radicals with dimethyl acetylenedicarboxylate and related compounds (1975) (2)
Acylarylnitrosamines. Part IX. Use of benzyne promoters in the conversion of N-nitrosoacetanilide into benzyne (1976) (2)
4‐Substituted 1‐Methyl‐1H‐2,3‐benzodiazepine Compounds (1995) (2)
2,5-Dimethylfuran : a remarkably efficient scavenger of dibenzoyl peroxide in benzene (1971) (2)
Reactions of triene-conjugated nitrile ylides: a route to 1,4-dihydro-1,4-prop-1′-enoisoquinolines from systems with α,β aromatic and γ,δ; Îµ,ζ olefinic unsaturation (1996) (2)
Relationship of radiographic progression to the pathogenic mechanism of rheumatoid arthritis: comment on the article by Molenaar et al. (2004) (2)
Antivascular antibody. (1974) (2)
Electrocyclic aromatic substitution by the diazo group. Part 4. Periselectivity studies on the cyclisation of 1-thienyl-3-diazoalkenes: a route to 3H-thieno[1,2]diazepines (1984) (1)
Reactions of bromodurene and related compounds with strong bases: a novel 1,3-dehydrobromination (1971) (1)
The reactivity of organophosphorus compounds. Part XXIII. Reactions of triethyl phosphite with carbon tetrachloride and bromotrichloromethane in the presence and absence of butane-1-thiol (1969) (1)
Electrocyclic aromatic substitution by the diazo-group. Part 3. Studies on substituent directive effects and on the mechanism of benzo-1,2-diazepine formation by the cyclisation of 1-aryl-3-diazoalkenes (1984) (1)
Acylarylnitrosamines. Part VIII. 15N-Labelling experiments and their relevance to the mechanisms of formation of benzyne from benzenediazonium acetate and of the benzenediazonium ion from hydroxyazo-compounds (1975) (1)
New evidence on the nature of the intermediate leading to aryne adducts in decompositions of acylarylnitrosamines (1970) (1)
Thermal ring transformation of 3H-1,2-diazepines to 4-alkenyl-1H-pyrazoles via ring contraction and sigmatropic vinyl group migration (1979) (1)
Acylarylnitrosamines. Part VII. [2H] Labelling experiments and the mechanism of formation of benzyne from N-nitrosoacetanilide and benzenediazonium acetate (1974) (1)
Conversion of 1-phenylazo-2-naphthol into the benzenediazonium ion: another route to phenyl radicals (1973) (1)
Acylarylnitrosamines. Part 12. Decomposition of N-nitrosoacetanilide and p-nitro-N-nitrosoacetanilide in bromotrichloromethane. An answer to the long-standing problem of the mechanism of ‘anomalous’ dual halogen abstractions (1977) (1)
Acylarylnitrosamines. Part X. An electron spin resonance spectroscopic investigation of the reactions of aryl radicals with tetraphenylcyclopentadienone and 2,3-diarylindenones : detection of 1-oxo-2,2,3-triphenylindenyl and related radicals and their relevance to dienonepromoted formation of benzyn (1976) (1)
Acylarylnitrosamines. Part 13. Promotion of ionic reactions of o- and p-chloro-, o- and p-acetoxy-, and o-acetylthio-N-nitrosoacetanilides. Formation of hydroxybenzenediazonium salts, the carbene 2-oxocyclohexa-3,5-dienylidene, and 1,2,3-benzothiadiazole (1977) (1)
THE SYNTHESIS OF 3H-1,2-DIAZEPINES BY THE BASE-INDUCED ELIMINATION OF TOLUENE-P-SULFINIC ACID FROM 3,4-DIHYDRO-2-TOSYL-1,2-DIAZEPINES, AND SOME OBSERVATIONS ON SIGMATROPIC HYDROGEN SHIFTS IN THE 3H-1,2-DIAZEPINE SYSTEM (1979) (0)
THE PREPARATION OF ISOQUINOLINE-N-IMINES BY THE REACTION OF 1-ACYL-2-(2′-OXOALKYL)ARENES WITH HYDRAZIDES (1985) (0)
Clinicopathologic diagnosis of thrombotic thrombocytopenic purpura: case report. (1968) (0)
SPIN TRAPPING BY TETRAPHENYLCYCLOPENTADIENONE AND 2,3-DIARYLINDENONES, NEW LONG-LIVED RADICALS AND THEIR RELEVANCE TO BENZYNE PROMOTION FROM BENZENEDIAZONIUM ACETATE (1975) (0)
ON THE FORMATION OF BENZENEDIAZONIUM CHLORIDE IN GOMBERG-HEY TYPE REACTIONS OF DIAZONIUM SALTS WITH BROMOTRICHLOROMETHANE, CARBON TETRACHLORIDE, AND CHLOROFORM. THE SOLUTION OF A LONG-STANDING MECHANISTIC PUZZLE (1977) (0)
ACYLARYLNITROSAMINES PART 8, (15)N-LABELLING EXPERIMENTS AND THEIR RELEVANCE TO THE MECHANISMS OF FORMATION OF BENZYNE FROM BENZENEDIAZONIUM ACETATE AND OF THE BENZENEDIAZONIUM ION FROM HYDROXYAZOCOMPOUNDS (1975) (0)
ELECTROCYCLIC AROMATIC SUBSTITUTION BY THE DIAZO GROUP. PART 3. STUDIES ON SUBSTITUENT DIRECTIVE EFFECTS AND ON THE MECHANISM OF BENZO-1,2-DIAZEPINE FORMATION BY THE CYCLIZATION OF 1-ARYL-3-DIAZOALKENES (1984) (0)
Benzoxepine Formation by the 1,7 Electrocyclization of Diene‐Conjugated Carbonyl Ylides: Studies on Relative Rates of Cyclization via Intramolecular Competition Reactions. (1998) (0)
A ROUTE TO 3H-1,2-DIAZEPINES BY THE 1,7-ELECTROCYCLIZATION OF α,β;Γ,Δ-UNSATURATED DIAZO COMPOUNDS (1984) (0)
Benzazepine Formation by the 1.7 Electrocyclizations of Diene‐ Conjugated Nitrile Ylides: Relative Rates of Cyclization via Intramolecular Competition Reactions. (1996) (0)
CYCLISATION OF ALPHA-(O-ALKENYLARYL)DIAZOALKANES, A ROUTE TO 2,3-BENZODIAZEPINES VIA A NOVEL 1,7-ELECTROCYCLIC RING CLOSURE (1974) (0)
The effect of glucocorticosteroids on antigen-induced leukocyte migration inhibition. (1979) (0)
Seven-membered ring compounds containing oxygen or sulphur in the ring (1975) (0)
ACYLARYLNITROSAMINES. PART 11. RELATIVE EFFICIENCIES OF 1,1-DIPHENYLETHENE, DIBENZOFULVENE, 1,1-DI(4-BIPHENYLYL)ETHENE, AND CUMENE IN PROMOTION OF ARYNE FORMATION FROM N-NITROSOACETANILIDE AND P-TERT-BUTYL-N-NITROSOACETANILIDE (1977) (0)
4‐Substituted 1‐Methyl‐1H‐2,3‐benzodiazepine Compounds. (1996) (0)
ACYLARYLNITROSAMINES. PART 12. DECOMPOSITION OF N-NITROSOACETANILIDE AND P-NITRO-N-NITROSOACETANILIDE IN BROMOTRICHLOROMETHANE. AN ANSWER TO THE LONG-STANDING PROBLEM OF THE MECHANISM OF ′ANOMALOUS′ DUAL HALOGEN ABSTRACTIONS (1977) (0)
Pulse Methotrexate Therapy in Rheumatoid Arthritis (2020) (0)
Reactions of Triene-Conjugated Nitrile Ylides: A Route to 1,4-Dihydro- 1,4-prop-1′-enoisoquinolines from Systems with α,β-Aromatic and γ,δ; .epsilon.,ζ-Olefinic Unsaturation. (2010) (0)
EVIDENCE FOR 1,2‐KETOCARBENES IN THERMOLYSIS OF SODIUM O‐HALOGENOPHENOXIDES AND FOR BENZOTHIIRENS IN THERMOLYSIS OF SODIUM O‐BROMOBENZENETHIOLATES (1975) (0)
ACYLARYLNITROSAMINES PART 7, ((2)H) LABELLING EXPERIMENTS AND THE MECHANISM OF FORMATION OF BENZYNE FROM N-NITROSOACETANILIDE AND BENZENEDIAZONIUM ACETATE (1974) (0)
THE EFFECT OF ALKENE CONFIGURATION ON THE PARTITIONING BETWEEN THE CARBENIC REACTIONS AND THE 1,7-ELECTROCYCLIZATION OF α-(O-ALKENYLARYL)DIAZOALKANES (1981) (0)
The Generation and Reactions of C,N-Dianions of Aromatic Tosylhydrazones: o-N- Dilithiated Benzophenone Tosylhydrazone. (1986) (0)
CYCLISATION REACTIONS OF 1-ARYL-3-DIAZOALKENES, A NEW REARRANGEMENT OF 3H-PYRAZOLES TO 3H-1,2-BENZODIAZEPINES (1975) (0)
Electrocyclic Aromatic Substitution by the Diazo Group. Part 4. Periselectivity Studies on the Cyclisation of 1-Thienyl-3-diazoalkenes: a Route to 3H-Thieno[1,2]diazepines. (1984) (0)
A Route to Dihydro(2)benzooxepino(4,5‐c)pyridines and Dihydrothieno(d) (2)benzooxepines via the 1.7‐Electrocyclization of Carbonyl Ylides. (1996) (0)
Chapter 51 – Seven-membered ring compounds containing nitrogen in the ring (1975) (0)
REACTION OF PHENYL RADICALS WITH DIALKYL AZODIFORMATES, FORMATION OF, AND NUCLEAR MAGNETIC RESONANCE STUDIES OF CONFORMATIONAL RESTRICTIONS IN, TETRAALKYL 1,4-DIPHENYLTETRA-AZANE-1,2,3,4-TETRACARBOXYLATES (1975) (0)
Comment on: Relationship of radiographic progression to the pathogenic mechanism of rheumatoid arthritis. by Molenaar et al (2004) (0)
A STUDY OF PERISELECTIVITY IN THE THERMAL CYCLIZATION REACTIONS OF DIENE-CONJUGATED DIAZO COMPOUNDS: 1,7-CYCLIZATION AS A ROUTE TO 3H-1,2-DIAZEPINES AND 1,5-CYCLIZATION LEADING TO NEW REARRANGEMENT REACTIONS OF 3H-PYRAZOLES (1985) (0)
THE ACYLATION OF 5H-2,3-BENZODIAZEPINES. REACTIONS OF 4-PHENYL-5H-2,3-BENZODIAZEPINE WITH ACYL CHLORIDES TO GIVE N-ACYLAMINOISOQUINOLINES AND/OR ACYLATED DIMERS. X-RAY MOLECULAR STRUCTURE OF 5,14-DIACETYL-4,5,8,9-TETRAHYDRO-2,7-DIPHEN (1984) (0)
A Route to 1,4‐Prop[2]enoisoquinolines via the Cyclization of Triene‐Conjugated Nitrile Ylides. (1999) (0)
Transverse Myelopathy in Systemic Lupus Erythematosus (2020) (0)
REACTIONS OF DIENE-CONJUGATED 1,3-DIPOLAR INTERMEDIATES: THE FORMATION OF CYCLOPROP(C)ISOQUINOLINES FROM BENZONITRILE O-ALKENYLBENZYL YLIDES AND THEIR REARRANGEMENTS TO 2-BENZAZEPINES (1985) (0)
ACID-CATALYZED CYCLIZATION OF αβ,ΓΔ-UNSATURATED P-TOLYLSULFONYLHYDRAZONES TO 3,4-DIHYDRO-2-TOLYLSULFONYL-1,2-DIAZEPINES (1979) (0)
THERMAL RING TRANSFORMATION OF 3H-1,2-DIAZEPINES TO 4-ALKENYL-1H-PYRAZOLESVIA RING CONTRACTION AND SIGMATROPIC VINYL GROUP MIGRATION (1980) (0)
1,7-Electrocyclic Substitution by Nitrile Ylides: The Effect on the Reaction Rate of the Nature of the γ,δ-Double Bond and of Aromatic Substituents. (1991) (0)
Attempts to apply curve fitting models to the analysis of progression of radiographic damage in rheumatoid arthritis are laudable, but are the results believable? (1994) (0)
ACYLARYLNITROSAMINES. X. ESR (1976) (0)
An Easy Route to Dibenz(c,e)azepines via Nitrile Ylide Cyclization: The Electrocyclic Equivalent of a Bischler-Napieralski Reaction. (1988) (0)
Clinicopathologic conference. (1968) (0)
7-Phenyl-5H-dibenz[c,e]azepine N-oxide (2001) (0)
FORMATION OF DIIRON HEXACARBONYL COMPLEXES OF 3H‐1,2‐DIAZEPINES AND THE EFFECTS OF COMPLEXATION ON RING INVERSION AND THE RATE OF SIGMATROPIC HYDROGEN MIGRATION (1984) (0)
USE OF BENZYNE PROMOTERS IN THE CONVERSION OF BENZENDIAZONIUM ACETATE INTO BENZYNE (1975) (0)
IN SITU FORMATION OF ARENEDIAZONIUM SALTS AND ARYL RADICALS BY APROTIC NITROSATION OF 1,3-DIARYLTRIAZENES- DUAL HALOGEN ABSTRACTION FROM BROMOTRICHLOROMETHANE, AND RADICAL ARYLATION OF AROMATIC COMPOUNDS (1977) (0)
1,7-ELECTROCYCLIZATION AND CARBENE REACTIONS OF O-ALKENYLARYLDIAZOALKANES: THE EFFECT OF ALKENE CONFIGURATION ON THE MODE OF REACTION (1984) (0)
STERIC EFFECTS IN THE REACTIONS OF ALPHA,BETA-UNSATURATED KETONE P-TOLYLSULPHONYL-HYDRAZONES, A ROUTE TO 1,2-BENZODIAZEPINES VIA 1,7-RING CLOSURE OF 1,1-DIARYL-3-DIAZOALKENES (1975) (0)
PHOTOCHEMICAL REACTIONS OF 1H-2,3-BENZODIAZEPINES- VALENCE ISOMERISATION OF A 1,2-DIAZABUTADIENE TO A DIAZETINE (1976) (0)
THE ACYLATION OF 5H-2,3-BENZODIAZEPINES AND 4H-THIENO(2,3-D)- AND 8H-THIENO(3,2-D)(1,2)DIAZEPINES. REACTIONS WITH ACID ANHYDRIDES AND NUCLEOPHILES TO GIVE FUSED 7-SUBSTITUTED 1-ACYL-1,2-DIAZEPINES (1984) (0)
CONVERSION OF 1‐PHENYLAZO‐2‐NAPHTHOL INTO THE BENZENEDIAZONIUM ION, ANOTHER ROUTE TO PHENYL RADICALS (1973) (0)
Seropositive Rheumatoid Arthritis Any Time During the First 15 Months After Symptom Onset in Patients with Equivalent Responses to Disease-modifying Antirheumatic Drugs Initiated at (2010) (0)
REACTIONS OF TRIENE-CONJUGATED NITRILE YLIDES : A ROUTE TO 1,4-DIHYDRO-1,4-PROP-1'-ENOISOQUINOLINES FROM SYSTEMS WITH ALPHA ,BETA AROMATIC AND GAMMA ,DELTA ;EPSILON ,ZETA OLEFINIC UNSATURATION (1996) (0)
ELECTROCYCLIC AROMATIC SUBSTITUTION BY THE DIAZO GROUP. PART 5. THE REACTIONS S OF α-(2-ARYLTHIENYL)DIAZOALKANES (1984) (0)
The Cyclization of Benzonitrile 3,3-Diarylallyl Ylides to give 3H-2-Benzazepines: Substituent Directive Effects and Mechanism. (1987) (0)
8.Repair in rheumatoid arthritis, current status. Report of a workshop at OMERACT (2007) (0)
The Preparation of Some 1,7b‐Disubstituted Cyclopropa[c]isoquinolines (IV) via Nitrile Ylide Cyclizations and Their Rearrangement to 2‐Benzazepines (V) and 4‐Alkenyl‐1,4‐dihydroisoquinolines (VI). (1998) (0)
ELECTROCYCLIC AROMATIC SUBSTITUTION BY THE DIAZO GROUP. PART 2. RING SIZE EFFECTS ON THE CYCLIZATION OF 1-ARYL-3-DIAZOALKANES: A NEW REARRANGEMENT OF 3H-PYRAZOLES TO 3H-1,2-BENZODIAZEPINES (1979) (0)
INTERCONVERSION OF FIVE- AND SEVEN-MEMBERED CYCLIC AZO-COMPOUNDS, A 1,3-AZOGROUP MIGRATION STUDIED BY HIGH-SPEED LIQUID CHROMATOGRAPHY (1974) (0)
Acylarylnitrosamines. Part 13. Promotion of Ionic Reactions of o- and p-Chloro-, o- and p-Acetoxy-, and o-Acetylthio-N-nitrosoacetanilides. Formation of Hydroxy-benzenediazonium Salts, the Carbene 2-Oxocyclohexa-3,5-dienylidene, and l (1977) (0)
Electrocyclic Aromatic Substitution by Nitrile Ylides to Give 3H‐2‐ Benzazepines: Substituent Effects and Mechanism. (1992) (0)
The role of [2H]-labelling in the determination of the mechanism of formation of benzyne from benzenediazonium acetate (1974) (0)
PHOTOCHEMICAL ISOMERIZATION OF 3H-1,2-DIAZEPINES TO 4,6A-DIHYDRO(1,2)DIAZETO(1,4-A)PYRROLES (1980) (0)
A NOTE ON THREE ROUTES TO BENZYNE, DECOMPOSITION OF DIPHENYLIODONIUM ACETATE, NITROSATION OF N-PHENYLPHOSPHYLAMIDATES, AND DEOXYGENATION OF BENZENEDIAZOTOLUENE-P-SULPHONATE N′-OXIDE (CUPFERRON TOSYLATE) BY PHOSPHORUS TRICHLORIDE (1975) (0)
THE SYNTHESIS OF 1H- AND 5H-THIENO(1,2)DIAZEPINES BY THE ELECTROCYCLIZATION OF α-(2-ALKENYLTHIENYL)DIAZOALKANES, AND SOME OBSERVATIONS ON THEIR PHOTOCHEMICAL REACTIVITY AND RING INVERSION (1980) (0)
THE THERMAL AND PHOTOCHEMICAL REACTIONS OF 3H-1,2-DIAZEPINES. A NEW VARIATION ON THE DIAZEPINE-PYRAZOLE REARRANGEMENT (1976) (0)
Asymmetric Induction in the Electrocyclizations of 1,3‐Dipolar Intermediates: The 1.7 Cyclization of Diene‐Conjugated Diazo‐Compounds to Give 1H‐2,3‐Benzodiazepines. (1995) (0)
Editorial: Gonococcal infections and arthritis. (1974) (0)
Identification of radiologic healing phenomena in patients with rheumatoid arthritis. (2002) (0)
Radiological progression inrheumatoid arthritis: howmany patients arerequired inatreatmenttrial totestdisease modification? (1993) (0)
N,N‐Dibenzoyl‐2‐phenylbenzylamine (1996) (0)
Reactions of Triene‐Conjugated Diazo‐Compounds: Reaction Paths from o‐(1,3‐Dienyl)aryldiazomethanes to 3,8‐Methano‐1,2‐diazocines and to Pyrrolo[2,1‐a]phthalazines via Intramolecular [3 + 2] and 1,1‐Cycloaddition Reactions. (2000) (0)
An Efficient General Route to Furo‐, Pyrido‐ and Thieno‐(d)(2) benzazepines via Pd(0) Catalyzed Cross Coupling Reactions and Nitrile Ylide Cyclizations. (1994) (0)
NOVEL REACTIONS OF DIAZONIUM SALTS- D (1977) (0)
Reaction of aromatic aldehydes with 1,2-dibenzylhydrazine (1985) (0)

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