John A. Tainer

John A. Tainer's AcademicInfluence.com Rankings

John A. Tainer

Chemistry

#1385

World Rank

#2083

Historical Rank

chemistry Degrees

John A. Tainer

Biology

#4104

World Rank

#6165

Historical Rank

Molecular Biology

#296

World Rank

#301

Historical Rank

Biochemistry

#417

World Rank

#496

Historical Rank

biology Degrees

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Chemistry
Biology

John A. Tainer's Degrees

PhD Biochemistry University of California, Berkeley
Masters Chemistry Stanford University
Bachelors Chemistry Stanford University

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John A. Tainer's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase. (1993) (1443)
Structural Biology of Rad50 ATPase ATP-Driven Conformational Control in DNA Double-Strand Break Repair and the ABC-ATPase Superfamily (2000) (952)
Structure and mechanism of copper, zinc superoxide dismutase (1983) (815)
Determination and analysis of the 2 A-structure of copper, zinc superoxide dismutase. (1980) (804)
Type IV pilus structure and bacterial pathogenicity (2004) (715)
X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution (2007) (678)
Accurate assessment of mass, models and resolution by small-angle scattering (2013) (624)
Structure of nitric oxide synthase oxygenase dimer with pterin and substrate. (1998) (605)
Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS) (2009) (591)
DNA-bound structures and mutants reveal abasic DNA binding by APE1 DNA repair and coordination (2000) (586)
The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair (2002) (578)
Structural Biochemistry and Interaction Architecture of the DNA Double-Strand Break Repair Mre11 Nuclease and Rad50-ATPase (2001) (516)
Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair (2008) (489)
Structure of the fibre-forming protein pilin at 2.6 Å resolution (1995) (487)
A nucleotide-flipping mechanism from the structure of human uracil–DNA glycosylase bound to DNA (1996) (486)
Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis (1990) (481)
Electrostatic recognition between superoxide and copper, zinc superoxide dismutase (1983) (472)
DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. (2014) (460)
X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution. (2011) (455)
Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure. (1995) (439)
Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template. (2007) (438)
Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil‐DNA glycosylase with DNA (1998) (435)
Characterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod-Debye law. (2011) (434)
Accurate SAXS profile computation and its assessment by contrast variation experiments. (2013) (429)
The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein (1984) (427)
The structural biochemistry of the superoxide dismutases. (2010) (414)
The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles (1992) (400)
Type IV pilus structure by cryo-electron microscopy and crystallography: implications for pilus assembly and functions. (2006) (398)
Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism. (2000) (387)
Biogenesis of chemotactic molecules by the arachidonate lipoxygenase system of platelets (1975) (365)
SUMO‐targeted ubiquitin ligases in genome stability (2007) (347)
Crystal structure and mutational analysis of human uracil-DNA glycosylase: Structural basis for specificity and catalysis (1995) (346)
XPD Helicase Structures and Activities: Insights into the Cancer and Aging Phenotypes from XPD Mutations (2008) (345)
Structure and function of the multifunctional DNA-repair enzyme exonuclease III (1995) (344)
Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair (2009) (331)
PD-L1-Mediated Gasdermin C Expression Switches Apoptosis to Pyroptosis in Cancer Cells and Facilitates Tumor Necrosis (2020) (331)
ModBase, a database of annotated comparative protein structure models and associated resources (2013) (328)
FoXS, FoXSDock and MultiFoXS: Single-state and multi-state structural modeling of proteins and their complexes based on SAXS profiles (2016) (327)
The structure of nitric oxide synthase oxygenase domain and inhibitor complexes. (1997) (314)
Nickel superoxide dismutase structure and mechanism. (2004) (313)
Microbial metalloproteomes are largely uncharacterized (2010) (311)
Identification of a new cryptochrome class. Structure, function, and evolution. (2003) (305)
Atomic structures of wild-type and thermostable mutant recombinant human Cu,Zn superoxide dismutase. (1992) (288)
The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra‐helical deoxyribose at DNA abasic sites (1997) (286)
MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily (1998) (285)
erratum: DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination (2000) (281)
Type IV pilin structure and assembly: X-ray and EM analyses of Vibrio cholerae toxin-coregulated pilus and Pseudomonas aeruginosa PAK pilin. (2003) (279)
Crystal structures of a schistosomal drug and vaccine target: glutathione S-transferase from Schistosoma japonica and its complex with the leading antischistosomal drug praziquantel. (1995) (277)
Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair (2004) (275)
Structure of the DNA Repair Enzyme Endonuclease IV and Its DNA Complex Double-Nucleotide Flipping at Abasic Sites and Three-Metal-Ion Catalysis (1999) (267)
DNA binding and nucleotide flipping by the human DNA repair protein AGT (2004) (267)
Atomic structure of the DNA repair [4Fe-4S] enzyme endonuclease III. (1992) (266)
Full‐length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2 (2003) (261)
Structure of the DNA Repair and Replication Endonuclease and Exonuclease FEN-1 Coupling DNA and PCNA Binding to FEN-1 Activity (1998) (261)
Structural Basis for Isozyme-specific Regulation of Electron Transfer in Nitric-oxide Synthase*[boxs] (2004) (256)
Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: Protein mimicry of DNA (1995) (249)
Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily (2011) (247)
The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair. (2018) (244)
Crystal Structure and Mutational Analysis of the Human CDK2 Kinase Complex with Cell Cycle–Regulatory Protein CksHs1 (1996) (244)
Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: the 3' ends justify the means. (2000) (239)
Chemistry of antibody binding to a protein. (1987) (236)
A SIM-ultaneous role for SUMO and ubiquitin. (2008) (235)
Evolution and mechanism from structures of an ADP-ribosylating toxin and NAD complex (1999) (232)
Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks. (2010) (232)
Structure of a Designed Protein Cage that Self-Assembles into a Highly Porous Cube (2014) (230)
Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome. (2005) (227)
A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation. (2010) (227)
A Role for Acidic Residues in Di-leucine Motif-based Targeting to the Endocytic Pathway (*) (1995) (223)
Rad50/SMC proteins and ABC transporters: unifying concepts from high-resolution structures. (2003) (216)
MDB: the Metalloprotein Database and Browser at The Scripps Research Institute (2002) (216)
Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects. (2000) (216)
The intricate structural chemistry of base excision repair machinery: implications for DNA damage recognition, removal, and repair. (2007) (202)
Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex* (2009) (201)
DNA base damage recognition and removal: new twists and grooves. (2005) (200)
Exploring the repeat protein universe through computational protein design (2015) (199)
ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization. (2003) (197)
The chemistry and mechanism of antibody binding to protein antigens. (1988) (195)
Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase (2008) (195)
Cancer, cadmium and genome integrity (2003) (193)
DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]. (2000) (193)
Evolution of CuZn superoxide dismutase and the Greek Key β‐barrel structural motif (1989) (190)
Mechanisms of antibody binding to a protein. (1987) (189)
Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding (2000) (184)
Human mitochondrial manganese superoxide dismutase polymorphic variant Ile58Thr reduces activity by destabilizing the tetrameric interface. (1996) (183)
Mechanism and energetics of green fluorescent protein chromophore synthesis revealed by trapped intermediate structures (2003) (182)
The atomic mobility component of protein antigenicity. (1985) (181)
Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products. (1999) (180)
Super-resolution in solution X-ray scattering and its applications to structural systems biology. (2013) (177)
Implementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source (2013) (174)
Structure and mechanism of the RuvB Holliday junction branch migration motor. (2001) (171)
Emerging critical roles of Fe-S clusters in DNA replication and repair. (2015) (170)
Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits. (1996) (166)
XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair*♦ (2011) (166)
Excision of cytosine and thymine from DNA by mutants of human uracil‐DNA glycosylase. (1996) (164)
DNA double-strand break repair from head to tail. (2002) (162)
DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy. (2007) (161)
DNA repair mechanisms for the recognition and removal of damaged DNA bases. (1999) (160)
2017 publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution: an update (2017) (157)
Identical short peptide sequences in unrelated proteins can have different conformations: a testing ground for theories of immune recognition. (1985) (157)
A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA. (2006) (157)
Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN (2016) (156)
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage (2006) (154)
Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors. (1993) (153)
Structural basis for endothelial nitric oxide synthase binding to calmodulin (2003) (151)
XPB and XPD helicases in TFIIH orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via CAK kinase. (2011) (151)
WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing (2006) (150)
Structural insights into the interaction of IL-33 with its receptors (2013) (148)
Bridging the solution divide: comprehensive structural analyses of dynamic RNA, DNA, and protein assemblies by small-angle X-ray scattering. (2010) (146)
Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair. (2006) (145)
High-throughput SAXS for the characterization of biomolecules in solution: a practical approach. (2014) (143)
Influence of protein flexibility and peptide conformation on reactivity of monoclonal anti-peptide antibodies with a protein alpha-helix. (1987) (143)
Crystal structure and novel recognition motif of rho ADP-ribosylating C3 exoenzyme from Clostridium botulinum: structural insights for recognition specificity and catalysis. (2001) (143)
Mre11 and Rad50 from Pyrococcus furiosus: Cloning and Biochemical Characterization Reveal an Evolutionarily Conserved Multiprotein Machine (2000) (135)
Structural characterization of zinc-deficient human superoxide dismutase and implications for ALS. (2007) (134)
Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans (2001) (130)
Structural Tuning of the Fluorescent Protein iLOV for Improved Photostability* (2012) (129)
Consequences of the loss of O‐linked glycosylation of meningococcal type IV pilin on piliation and pilus‐mediated adhesion (1998) (128)
Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1 (1995) (126)
The interdependence of protein surface topography and bound water molecules revealed by surface accessibility and fractal density measures. (1992) (123)
Superoxide dismutase from the eukaryotic thermophile Alvinella pompejana: structures, stability, mechanism, and insights into amyotrophic lateral sclerosis. (2009) (122)
Screening a peptidyl database for potential ligands to proteins with side‐chain flexibility (1998) (122)
Type-4 pilus-structure: outside to inside and top to bottom--a minireview. (1997) (119)
Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control. (1993) (119)
ATP‐driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling (2014) (118)
XLF regulates filament architecture of the XRCC4·ligase IV complex. (2010) (116)
Envisioning the molecular choreography of DNA base excision repair. (1999) (116)
Subunit-destabilizing mutations in Drosophila copper/zinc superoxide dismutase: neuropathology and a model of dimer dysequilibrium. (1995) (115)
Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase. (1999) (114)
Structures of the N(omega)-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins. (2000) (113)
Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes (2009) (112)
Lessons learned from structural results on uracil-DNA glycosylase. (2000) (112)
Metal-binding sites in proteins. (1991) (106)
Substrate specificity of prostate-specific antigen (PSA). (1998) (104)
Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time. (2014) (104)
HU multimerization shift controls nucleoid compaction (2016) (102)
Crystallographic structure reveals phosphorylated pilin from Neisseria: phosphoserine sites modify type IV pilus surface chemistry and fibre morphology (1999) (102)
Structural chemistry of a green fluorescent protein Zn biosensor. (2002) (101)
Crystal structure of Y34F mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34. (1998) (101)
Antibody remodeling: a general solution to the design of a metal-coordination site in an antibody binding pocket. (1990) (100)
Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequences (2016) (99)
Changes in crystallographic structure and thermostability of a Cu,Zn superoxide dismutase mutant resulting from the removal of a buried cysteine. (1993) (99)
Comprehensive macromolecular conformations mapped by quantitative SAXS analyses (2013) (99)
N‐terminal domain swapping and metal ion binding in nitric oxide synthase dimerization (1999) (98)
XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair. (2013) (97)
Hexameric structures of the archaeal secretion ATPase GspE and implications for a universal secretion mechanism (2007) (97)
A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors (2021) (94)
The role of arginine 143 in the electrostatics and mechanism of Cu, Zn superoxide dismutase: Computational and experimental evaluation by mutational analysis (1994) (94)
Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair. (2015) (94)
The rad50 signature motif: essential to ATP binding and biological function. (2003) (93)
DNA apurinic-apyrimidinic site binding and excision by endonuclease IV (2008) (93)
ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair (2011) (92)
The ARTT motif and a unified structural understanding of substrate recognition in ADP-ribosylating bacterial toxins and eukaryotic ADP-ribosyltransferases. (2002) (91)
Base excision repair enzyme family portrait: integrating the structure and chemistry of an entire DNA repair pathway. (1997) (91)
Human DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound states. (2010) (89)
Insights into FlaI functions in archaeal motor assembly and motility from structures, conformations, and genetics. (2013) (87)
DNA charge transport as a first step in coordinating the detection of lesions by repair proteins (2012) (87)
The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once. (2014) (86)
A new structural framework for integrating replication protein A into DNA processing machinery (2013) (85)
Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease IV (2007) (84)
Electrostatic orientation of the electron-transfer complex between plastocyanin and cytochrome c. (1991) (84)
Transplanted LDL and mannose‐6‐phosphate receptor internalization signals promote high‐efficiency endocytosis of the transferrin receptor. (1991) (84)
Improving small-angle X-ray scattering data for structural analyses of the RNA world. (2010) (83)
Proliferating cell nuclear antigen loaded onto double-stranded DNA: dynamics, minor groove interactions and functional implications (2006) (83)
Structures of endonuclease V with DNA reveal initiation of deaminated adenine repair (2009) (83)
Active conformation of an insect neuropeptide family. (1991) (83)
Insights into Lou Gehrig's disease from the structure and instability of the A4V mutant of human Cu,Zn superoxide dismutase. (2002) (82)
Genetically engineered polymers of human CuZn superoxide dismutase. Biochemistry and serum half-lives. (1989) (82)
Unusual trigonal-planar copper configuration revealed in the atomic structure of yeast copper-zinc superoxide dismutase. (1996) (81)
Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O(6)-alkylguanine-DNA alkyltransferase. (2000) (80)
Novel dimeric interface and electrostatic recognition in bacterial Cu,Zn superoxide dismutase. (1996) (80)
Conserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair Enzymes* (2013) (79)
The structure of the CRISPR-associated protein Csa3 provides insight into the regulation of the CRISPR/Cas system. (2011) (77)
Atomic and residue hydrophilicity in the context of folded protein structures (1995) (77)
Thermostabilization of recombinant human and bovine CuZn superoxide dismutases by replacement of free cysteines. (1991) (77)
Structural analysis of flexible proteins in solution by small angle X-ray scattering combined with crystallography. (2006) (77)
The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase (2007) (77)
Probing the active site of human manganese superoxide dismutase: the role of glutamine 143. (1998) (76)
Defining the role of arginine 96 in green fluorescent protein fluorophore biosynthesis. (2005) (76)
Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain. (1995) (76)
γH2A binds Brc1 to maintain genome integrity during S‐phase (2010) (76)
Structural biochemistry of a type 2 RNase H: RNA primer recognition and removal during DNA replication. (2001) (75)
ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining (2010) (75)
Report of the wwPDB Small-Angle Scattering Task Force: data requirements for biomolecular modeling and the PDB. (2013) (75)
Selenocysteine's mechanism of incorporation and evolution revealed in cDNAs of three glutathione peroxidases. (1988) (73)
Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex (2016) (73)
Evolving SAXS versatility: solution X-ray scattering for macromolecular architecture, functional landscapes, and integrative structural biology (2019) (73)
Structure and function of the double-strand break repair machinery. (2004) (72)
Crystal structure of the cell cycle-regulatory protein suc1 reveals a beta-hinge conformational switch. (1995) (72)
Metals in biology: defining metalloproteomes. (2012) (71)
Newly Discovered Archaebacterial Flap Endonucleases Show a Structure-Specific Mechanism for DNA Substrate Binding and Catalysis Resembling Human Flap Endonuclease-1* (1998) (70)
Crystallographic structures of Discosoma red fluorescent protein with immature and mature chromophores: linking peptide bond trans-cis isomerization and acylimine formation in chromophore maturation. (2005) (70)
Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability. (2008) (70)
Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability (2017) (68)
Understanding GFP chromophore biosynthesis: controlling backbone cyclization and modifying post-translational chemistry. (2005) (68)
Alkylated DNA damage flipping bridges base and nucleotide excision repair (2009) (68)
A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase. (2006) (68)
Protein mimicry of DNA and pathway regulation. (2005) (67)
Understanding GFP posttranslational chemistry: structures of designed variants that achieve backbone fragmentation, hydrolysis, and decarboxylation. (2006) (66)
Flap endonuclease homologs in archaebacteria exist as independent proteins. (1998) (65)
MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA (2012) (64)
Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA (2011) (64)
Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency. (2002) (64)
Kinetic Mechanism of Activation of the Cdk2/Cyclin A Complex (2002) (63)
Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases. (2012) (63)
Inducible nitric oxide synthase: role of the N‐terminal β‐hairpin hook and pterin‐binding segment in dimerization and tetrahydrobiopterin interaction (1999) (63)
Two novel SOD1 mutations in patients with familial amyotrophic lateral sclerosis. (1995) (62)
Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a unique substrate-binding element (2012) (62)
Erratum: Atomic structures of wild-type and thermostable mutant recombinant human Cu,Zn superoxide dismutase (Proc. Natl. Acad. Sci. USA (July 1992) 89:13 (6109-6113)) (1992) (61)
Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes (2014) (61)
Structure and activity of a thermostable thymine-DNA glycosylase: evidence for base twisting to remove mismatched normal DNA bases. (2002) (61)
Differential arrangements of conserved building blocks among homologs of the Rad50/Mre11 DNA repair protein complex. (2004) (60)
Mutational Analysis of the Tetrahydrobiopterin-binding Site in Inducible Nitric-oxide Synthase* (1999) (60)
Elucidating the structural chemistry of glycosaminoglycan recognition by protein C inhibitor. (1990) (58)
Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death (2019) (58)
Ultrahigh Resolution and Full-length Pilin Structures with Insights for Filament Assembly, Pathogenic Functions, and Vaccine Potential* (2011) (58)
ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair (2011) (57)
Anacardic Acid Inhibits the Catalytic Activity of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 (2012) (57)
An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex* (2016) (57)
Archaeal flagellar ATPase motor shows ATP-dependent hexameric assembly and activity stimulation by specific lipid binding. (2011) (57)
FlaF Is a β-Sandwich Protein that Anchors the Archaellum in the Archaeal Cell Envelope by Binding the S-Layer Protein (2015) (56)
Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair (2007) (56)
Kinetic analysis of product inhibition in human manganese superoxide dismutase. (2001) (56)
Tryptophan 409 Controls the Activity of Neuronal Nitric-oxide Synthase by Regulating Nitric Oxide Feedback Inhibition* (1999) (56)
Dissection of DNA double-strand break repair using novel single-molecule forceps (2018) (56)
Structural basis for recognition of 5′-phosphotyrosine adducts by TDP2 (2012) (56)
Crystallographic structure of a photoreceptor protein at 2.4 A resolution. (1989) (56)
Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis. (2009) (55)
Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: insertion of valine C gamma into the substrate access channel. (2003) (55)
Mechanism of DNA substrate recognition by the mammalian DNA repair enzyme, Polynucleotide Kinase (2009) (55)
ATP-stimulated, DNA-mediated redox signaling by XPD, a DNA repair and transcription helicase. (2011) (54)
The R-factor gap in macromolecular crystallography: an untapped potential for insights on accurate structures (2014) (54)
MacroBac: New Technologies for Robust and Efficient Large-Scale Production of Recombinant Multiprotein Complexes. (2017) (53)
Consensus chemistry and beta-turn conformation of the active core of the insect kinin neuropeptide family. (1997) (53)
Multiple replacements of glutamine 143 in human manganese superoxide dismutase: effects on structure, stability, and catalysis. (2000) (52)
Biochemical purification and crystallographic characterization of the fiber-forming protein pilin from Neisseria gonorrhoeae. (1990) (52)
The pilus‐induced Ca2+ flux triggers lysosome exocytosis and increases the amount of Lamp1 accessible to Neisseria IgA1 protease (2001) (51)
Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1. (2008) (51)
Science, citation, and funding. (1991) (50)
Structural and functional analysis of Mre11-3. (2004) (50)
Assembly and antigenicity of the Neisseria gonorrhoeae pilus mapped with antibodies (1996) (50)
Inducible Nitric Oxide Synthase (2011) (50)
Mechanistic insights into the role of Hop2–Mnd1 in meiotic homologous DNA pairing (2013) (50)
SUMO-Targeted Ubiquitin Ligase, Rad60, and Nse2 SUMO Ligase Suppress Spontaneous Top1–Mediated DNA Damage and Genome Instability (2011) (49)
The wonders of flap endonucleases: structure, function, mechanism and regulation. (2012) (49)
DNA conformations in mismatch repair probed in solution by X-ray scattering from gold nanocrystals (2013) (49)
New aspects of chemotaxis. Specific target-cell attraction by lipid and lipoprotein fractions of Escherichia coli chemotactic factor. (1975) (48)
Perchlorate Reductase Is Distinguished by Active Site Aromatic Gate Residues* (2016) (48)
Substrate recognition and catalysis by flap endonucleases and related enzymes. (2010) (48)
Molecular Mimicry of SUMO Promotes DNA Repair (2009) (48)
Recognition of the Ring-Opened State of Proliferating Cell Nuclear Antigen by Replication Factor C Promotes Eukaryotic Clamp-Loading (2010) (47)
Three Metal Ions Participate in the Reaction Catalyzed by T5 Flap Endonuclease* (2008) (47)
Structural dynamics in DNA damage signaling and repair. (2010) (46)
Transcription preinitiation complex structure and dynamics provide insight into genetic diseases (2019) (46)
The Rad50 hook domain regulates DNA damage signaling and tumorigenesis (2014) (46)
The disordered C-terminal domain of human DNA glycosylase NEIL1 contributes to its stability via intramolecular interactions. (2013) (45)
Exon 5 encoded domain is not required for the toxic function of mutant SOD1 but essential for the dismutase activity: identification and characterization of two new SOD1 mutations associated with familial amyotrophic lateral sclerosis (1997) (45)
Reaction Intermediates in the Catalytic Mechanism of Escherichia coli MutY DNA Glycosylase* (2004) (45)
Structural evidence for an enolate intermediate in GFP fluorophore biosynthesis. (2006) (45)
Crystal structure of the first eubacterial Mre11 nuclease reveals novel features that may discriminate substrates during DNA repair. (2010) (44)
DNA Repair and Global Sumoylation Are Regulated by Distinct Ubc9 Noncovalent Complexes (2011) (44)
Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability (2012) (44)
The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome (2011) (43)
The nucleotide‐dependent interaction of FlaH and FlaI is essential for assembly and function of the archaellum motor (2015) (43)
Flap endonucleases pass 5′-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5′-ends (2012) (43)
Predicting molecular interactions and inducible complementarity: Fragment docking of fab‐peptide complexes (1994) (42)
p38alpha MAP kinase C-terminal domain binding pocket characterized by crystallographic and computational analyses. (2009) (42)
RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response (2014) (42)
Characterization of the electrophile binding site and substrate binding mode of the 26‐kDa glutathione S‐transferase from Schistosoma japonicum (2003) (41)
2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution. (2004) (41)
The ATPase Activity of BfpD Is Greatly Enhanced by Zinc and Allosteric Interactions with Other Bfp Proteins* (2005) (41)
Protein metal-binding sites. (1992) (41)
Interrupting the Hydrogen Bond Network at the Active Site of Human Manganese Superoxide Dismutase* (1999) (41)
Interfacial Residues Promote an Optimal Alignment of the Catalytic Center in Human Soluble Guanylate Cyclase: Heterodimerization Is Required but Not Sufficient for Activity (2014) (40)
Intact Functional Fourteen-subunit Respiratory Membrane-bound [NiFe]-Hydrogenase Complex of the Hyperthermophilic Archaeon Pyrococcus furiosus* (2014) (40)
Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase. (2008) (40)
Structural dynamics and single-stranded DNA binding activity of the three N-terminal domains of the large subunit of replication protein A from small angle X-ray scattering. (2010) (39)
Solution structure of RNase P RNA. (2011) (39)
The case of the missing ring: radical cleavage of a carbon-carbon bond and implications for GFP chromophore biosynthesis. (2007) (38)
Crystal structure and mutational analysis of the Saccharomyces cerevisiae cell cycle regulatory protein Cks1: implications for domain swapping, anion binding and protein interactions. (2000) (38)
Crystallographic characterization of recombinant human CuZn superoxide dismutase. (1986) (38)
Mapping interactions between the RNA chaperone FinO and its RNA targets (2011) (37)
Recognition and interactions controlling the assemblies of beta barrel domains. (1986) (37)
Software for the high-throughput collection of SAXS data using an enhanced Blu-Ice/DCS control system (2010) (37)
Vibrio cholerae El Tor TcpA crystal structure and mechanism for pilus‐mediated microcolony formation (2010) (37)
RNA Modifications: Reversal Mechanisms and Cancer. (2018) (36)
Protein metal-binding sites (1992) (36)
The D90A mutation results in a polymorphism of Cu,Zn superoxide dismutase that is prevalent in northern Sweden and Finland. (1995) (36)
DNA repair proteins. (1995) (36)
A structure-specific nucleic acid-binding domain conserved among DNA repair proteins (2014) (35)
A nanomachine for making ends meet: MRN is a flexing scaffold for the repair of DNA double-strand breaks. (2005) (35)
Design of a monomeric human glutathione transferase GSTP1, a structurally stable but catalytically inactive protein. (2002) (35)
Altering the antigenicity of proteins. (1992) (35)
Structurally distinct ubiquitin- and sumo-modified PCNA: implications for their distinct roles in the DNA damage response. (2015) (35)
Purification and Characterization ofThermotoga maritima Endonuclease IV, a Thermostable Apurinic/Apyrimidinic Endonuclease and 3′-Repair Diesterase (1999) (34)
Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase (2012) (34)
Role of hydrogen bonding in the active site of human manganese superoxide dismutase. (2004) (34)
ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair (2012) (34)
The BARD1 C-Terminal Domain Structure and Interactions with Polyadenylation Factor CstF-50† (2008) (33)
Function of the Greek key connection analysed using circular permutants of superoxide dismutase (1997) (33)
Characterization of a Y-Family DNA Polymerase eta from the Eukaryotic Thermophile Alvinella pompejana (2010) (33)
Kinetic studies of reduction of a 1:1 cytochrome c-flavodoxin complex by free flavin semiquinones and rubredoxin. (1986) (33)
Eukaryotic Class II Cyclobutane Pyrimidine Dimer Photolyase Structure Reveals Basis for Improved Ultraviolet Tolerance in Plants* (2011) (32)
Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457. (2001) (32)
Mechanism of efficient double-strand break repair by a long non-coding RNA (2020) (32)
Crystallization and crystallographic characterization of the iron-sulfur-containing DNA-repair enzyme endonuclease III from Escherichia coli. (1992) (32)
Crystal and solution structures of a prokaryotic M16B peptidase: an open and shut case. (2009) (32)
Characterization of Y122F R2 of Escherichia coli ribonucleotide reductase by time-resolved physical biochemical methods and X-ray crystallography. (1998) (32)
Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor. (2016) (32)
Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding (2018) (32)
Designing and defining dynamic protein cage nanoassemblies in solution (2016) (31)
Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations (2020) (30)
Repair of O4-Alkylthymine by O6-Alkylguanine-DNA Alkyltransferases* (2009) (30)
Amino Acid Substitution at the Dimeric Interface of Human Manganese Superoxide Dismutase* (2004) (29)
Nitric-oxide Synthase Forms N-NO-pterin and S-NO-Cys (2010) (29)
DNA damage recognition and repair pathway coordination revealed by the structural biochemistry of DNA repair enzymes. (2001) (29)
Kinetic and Stoichiometric Characterisation of Streptavidin‐Binding Aptamers (2012) (29)
Identification of a Coiled Coil in Werner Syndrome Protein That Facilitates Multimerization and Promotes Exonuclease Processivity* (2010) (29)
Role of tryptophan 161 in catalysis by human manganese superoxide dismutase. (1999) (29)
The structure of the MAP2K MEK6 reveals an autoinhibitory dimer. (2009) (29)
Structure of an essential type IV pilus biogenesis protein provides insights into pilus and type II secretion systems. (2012) (29)
Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines. (2012) (29)
Structural and functional characterization of the PNKP–XRCC4–LigIV DNA repair complex (2017) (28)
Unraveling the effect of changes in conformation and compactness at the antibody VL‐VH interface upon antigen binding (1999) (28)
Cancer mutational burden is shaped by G4 DNA, replication stress and mitochondrial dysfunction. (2019) (28)
XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells (2020) (28)
Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1 (2017) (27)
Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors (2021) (27)
Repair activities of 8-oxoguanine DNA glycosylase from Archaeoglobus fulgidus, a hyperthermophilic archaeon. (2001) (26)
Charging of Proteins in Native Mass Spectrometry (2017) (26)
RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment* (2016) (26)
The pilus and porin of Neisseria gonorrhoeae cooperatively induce Ca2+ transients in infected epithelial cells (2005) (26)
DNA mismatch repair: the hands of a genome guardian. (2000) (25)
Mutation of an active site residue in Escherichia coli uracil-DNA glycosylase: effect on DNA binding, uracil inhibition and catalysis. (1999) (25)
Structural basis for recognition and catalysis by the bifunctional dCTP deaminase and dUTPase from Methanococcus jannaschii. (2003) (25)
Developing advanced X-ray scattering methods combined with crystallography and computation. (2013) (25)
Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease (2020) (25)
All Stressed Out Without ATM Kinase (2011) (25)
Erratum DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities. [Molecular Cell 53, 9, (2014) 7-18] (2014) (24)
Alkyltransferase-like proteins: molecular switches between DNA repair pathways (2010) (24)
Methods for using new conceptual tools and parameters to assess RNA structure by small-angle X-ray scattering. (2014) (24)
A Computational Framework for Proteome-Wide Pursuit and Prediction of Metalloproteins using ICP-MS and MS/MS Data (2011) (24)
Computational, pulse‐radiolytic, and structural investigations of lysine‐136 and its role in the electrostatic triad of human C u,Z n superoxide dismutase (1997) (23)
Small angle X‐ray scattering and cross‐linking for data assisted protein structure prediction in CASP 12 with prospects for improved accuracy (2018) (23)
The structure of the periplasmic FlaG–FlaF complex and its essential role for archaellar swimming motility (2019) (23)
Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair. (2020) (23)
Interaction Interface of Human Flap Endonuclease-1 with Its DNA Substrates* (2004) (22)
Structural Basis of O6-Alkylguanine Recognition by a Bacterial Alkyltransferase-like DNA Repair Protein* (2010) (22)
Cell-free expression of functional receptor tyrosine kinases (2015) (22)
Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair (2012) (22)
Small angle X‐ray scattering‐assisted protein structure prediction in CASP13 and emergence of solution structure differences (2019) (21)
Author Correction: PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis (2020) (21)
SLX4IP acts with SLX4 and XPF–ERCC1 to promote interstrand crosslink repair (2019) (21)
Hydrogen bonding in human manganese superoxide dismutase containing 3-fluorotyrosine. (2005) (21)
Formylglycine-generating enzyme binds substrate directly at a mononuclear Cu(I) center to initiate O2 activation (2019) (21)
Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation–π interactions (2012) (20)
Comparison of the catalytic parameters and reaction specificities of a phage and an archaeal flap endonuclease. (2007) (20)
Rational design and expression of a heparin-targeted human superoxide dismutase. (1993) (20)
Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joining (2015) (20)
Double strand binding–single strand incision mechanism for human flap endonuclease: Implications for the superfamily (2012) (20)
ATP Induces Conformational Changes in the Carboxyl-terminal Region of ClC-5* (2010) (19)
Archaeal Genome Guardians Give Insights into Eukaryotic DNA Replication and Damage Response Proteins (2014) (19)
Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities. (2018) (18)
Manganese Superoxide Dismutase (2006) (18)
Synthesis and characterization of oligonucleotides containing 2′-fluorinated thymidine glycol as inhibitors of the endonuclease III reaction (2006) (18)
Coprinus cinereus rad50 Mutants Reveal an Essential Structural Role for Rad50 in Axial Element and Synaptonemal Complex Formation, Homolog Pairing and Meiotic Recombination (2008) (18)
Probing the structural basis for enzyme-substrate recognition in Cu,Zn superoxide dismutase. (1991) (17)
Enzyme motifs in antibodies (1990) (17)
Polymerase Theta Inhibition Kills Homologous Recombination Deficient Tumors (2020) (17)
Hybrid Methods Reveal Multiple Flexibly Linked DNA Polymerases within the Bacteriophage T7 Replisome. (2017) (17)
Histone Acetyltransferase MOF Orchestrates Outcomes at the Crossroad of Oncogenesis, DNA Damage Response, Proliferation, and Stem Cell Development (2020) (17)
Gonococcal pilus: genetics and structure. (1985) (17)
Purification and crystallization of a schistosomal glutathione S‐Transferase (1995) (17)
Structural, Functional, and Immunogenic Insights on Cu,Zn Superoxide Dismutase Pathogenic Virulence Factors from Neisseria meningitidis and Brucella abortus (2015) (17)
Visualization of molecular flexibility and its effects on electrostatic recognition. (1990) (17)
ATP‐driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling (2016) (16)
Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy (2021) (16)
A mutation in the human cyclin-dependent kinase interacting protein, CksHs2, interferes with cyclin-dependent kinase binding and biological function, but preserves protein structure and assembly. (1996) (16)
The food of sweet and bitter fancy (2000) (16)
Mechanism and atomic structure of superoxide dismutase. (1991) (15)
Investigations of black bronchoalveolar human lavage fluid. (1977) (15)
Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin (2020) (15)
Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1. (2022) (14)
EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart. (2021) (14)
Neutralizing Mutations of Carboxylates That Bind Metal 2 in T5 Flap Endonuclease Result in an Enzyme That Still Requires Two Metal Ions* (2011) (14)
Manganese superoxide dismutase induction during measles virus infection (2003) (14)
The Salmonella Type III Secretion System Virulence Effector Forms a New Hexameric Chaperone Assembly for Export of Effector/Chaperone Complexes (2014) (13)
Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response (2020) (13)
Target highlights in CASP14: Analysis of models by structure providers (2021) (13)
Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites (2021) (13)
A collagen glucosyltransferase drives lung adenocarcinoma progression in mice (2021) (13)
Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis. (2019) (12)
An atypical BRCT–BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex (2020) (12)
GRB2 enforces homology-directed repair initiation by MRE11 (2021) (12)
Crystallization and preliminary crystallographic study of human CksHs1: A cell cycle regulatory protein (1995) (12)
Learning our ABCs: Rad50 directs MRN repair functions via adenylate kinase activity from the conserved ATP binding cassette. (2007) (12)
The ATPase Motor Turns for Type IV Pilus Assembly. (2016) (11)
Cracking tyrosine phosphatases (1994) (11)
X‐ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double‐strand break repair impacting cell and cancer biology (2021) (11)
Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer (2016) (11)
What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses. (2017) (11)
RNF 4 interacts with both SUMO and nucleosomes to promote the DNA damage response (2014) (10)
A Mutation in the FHA Domain of Coprinus cinereus Nbs1 Leads to Spo11-Independent Meiotic Recombination and Chromosome Segregation (2013) (10)
Glubodies: randomized libraries of glutathione transferase enzymes. (1996) (10)
An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation (2021) (10)
How substrate specificity is imposed on a histone demethylase—lessons from KDM2A (2014) (10)
Dancing with the elephants: envisioning the structural biology of DNA repair pathways. (2000) (9)
Visualizing functional dynamicity in the DNA-dependent protein kinase holoenzyme DNA-PK complex by integrating SAXS with cryo-EM. (2020) (9)
Erratum to “ALS Mutants of Human Superoxide Dismutase form Fibrous Aggregates via Framework Destabilization” [J. Mol. Biol. 332 (2003) 601–615] (2003) (8)
Sculpting of DNA at abasic sites by DNA glycosylase homolog mag2. (2013) (8)
Robust Production, Crystallization, Structure Determination, and Analysis of [Fe-S] Proteins: Uncovering Control of Electron Shuttling and Gating in the Respiratory Metabolism of Molybdopterin Guanine Dinucleotide Enzymes. (2018) (8)
Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2. (2005) (8)
1 KU AND DNA-DEPENDENT PROTEIN KINASE ( DNA-PK ) DYNAMIC CONFORMATIONS AND ASSEMBLY REGULATE DNA BINDING AND THE INITIAL NONHOMOLOGOUS END JOINING COMPLEX (2009) (8)
Structural Aspects of Ku and the DNA-Dependent Protein Kinase Complex (2005) (8)
Kinetic and structural characterization of human manganese superoxide dismutase containing 3-fluorotyrosines (2006) (8)
Replication‐Based Rearrangements Are a Common Mechanism for SNCA Duplication in Parkinson's Disease (2020) (8)
Purification, crystallization and space group determination of DNA repair enzyme exonuclease III from E. coli. (1993) (8)
Structural basis for recognition of 5 ′-phosphotyrosine adducts by TDP 2 (2013) (8)
The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc 9 DNA ligase (2007) (7)
Defining antibody-antigen recognition: towards engineered antibodies and epitopes. (1991) (7)
HUMAN APURINIC/APYRIMIDINIC ENDONUCLEASE-1 (APE1) BOUND TO ABASIC DNA (2000) (7)
Response : Antigenicity of Myohemerythrin (1987) (7)
STRUCTURE OF THE FIBER-FORMING PROTEIN PILIN AT 2.6 ANGSTROMS RESOLUTION (1998) (7)
Summary of `Superoxide Dismutase (SOD) and Free Radicals in Amyotrophic Lateral Sclerosis and Neurodegeneration' conference (1995) (7)
Structural Phylogenetics of DNA Base Excision Repair (1998) (7)
The Chemistry of Antigen-Antibody Union (1985) (6)
Crystallographic characterization of a Cu,Zn superoxide dismutase from Photobacterium leiognathi. (1990) (6)
Superoxide Dismutase Structures, Stability, Mechanism and Insights into the Human Disease Amyotrophic Lateral Sclerosis from Eukaryotic Thermophile Alvinella pompejana (2009) (6)
Mobility and evolutionary variability factors in protein antigenicity (reply) (1985) (6)
c H 2 A binds Brc 1 to maintain genome integrity during S-phase (2009) (6)
Superoxide Dismutase as a Model Ion Channel (1986) (6)
Synthesis and characterization of a recombinant myohemerythrin protein encoded by a synthetic gene. (1991) (6)
P53 conformational switching for selectivity may reveal a general solution for specific DNA binding (2011) (6)
Envisioning the fourth dimension of the genetic code: the structural biology of macromolecular recognition and conformational switching in DNA repair. (2000) (6)
Molecular recognition in DNA-binding proteins and enzymes. (1993) (5)
Probing DNA by 2-OG-Dependent Dioxygenase (2013) (5)
Three dimensional structure of bacterial pili (2004) (5)
Mechanism of efficient double-strand break repair by a long non-coding RNA (2020) (5)
Aberrant RNA methylation triggers recruitment of an alkylation repair complex. (2021) (5)
A Charged Performance by gp17 in Viral Packaging (2008) (5)
Autism-Associated Vigilin Depletion Impairs DNA Damage Repair (2021) (4)
Amyotrophic lateral sclerosis. (2010) (4)
Structural and functional analysis of Mre 11-3 (4)
Session 6 structural implications of BER enzymes: Dragons dancing-The structural biology of DNA base excision repair (2001) (4)
Author Correction: Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding (2018) (4)
Structural dynamics and ssDNA binding activity of the three N-terminal domains of the large subunit of Replication Protein A from small angle X-ray scattering (2010) (4)
Two interaction surfaces between XPA and RPA organize the preincision complex in nucleotide excision repair (2022) (4)
Achieving fidelity in homologous recombination despite extreme complexity: informed decisions by molecular profiling. (2010) (4)
Non-chemokinetic neutrophil attractants derived from arachidonic acid. (1983) (4)
Aberrant RNA methylation triggers recruitment of an alkylation repair complex (2020) (4)
Nitric-oxide Synthase Forms N-NO-pterin and SNO-Cys IMPLICATIONS FOR ACTIVITY (2010) (3)
Faculty Opinions recommendation of Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles. (2013) (3)
Structural Control of Nonnative Ligand Binding in Engineered Mutants of Phosphoenolpyruvate Carboxykinase. (2018) (3)
Dynamic structures in DNA damage responses & cancer. (2015) (3)
Modeling macromolecular motions by x-ray-scattering-constrained molecular dynamics. (2015) (3)
An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2 (2021) (3)
Decoding Cancer Variants of Unknown Significance for Helicase–Nuclease–RPA Complexes Orchestrating DNA Repair During Transcription and Replication (2021) (3)
The BARD1 C-Terminal Domain Structure and Interactions with Polyadenylation Factor CstF-50 (2009) (3)
Probing enzyme-substrate recognition and catalytic mechanism in Cu,Zn superoxide dismutase. (1988) (3)
Master Keys to DNA Replication, Repair, and Recombination from the Structural Biology of Enzymes from Thermophiles (2007) (3)
Understanding the structure and antigenicity of gonococcal pili. (1988) (3)
Faculty Opinions recommendation of The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells. (2018) (3)
EXONUCLEASE III FROM ESCHERICHIA COLI (1997) (3)
Nonpeptide chemotaxins isolated from bacterial growth media (1975) (3)
MITOCHONDRIAL MANGANESE SUPEROXIDE DISMUTASE VARIANT WITH ILE 58 REPLACED BY THR (1996) (3)
Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus (2021) (3)
Erratum: ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair (Nature Structural and Molecular Biology (2011) 18 (423-431)) (2011) (3)
SIBYLS — a SAXS and Protein Crystallography Beamline at the ALS (2003) (2)
Molecular biology: DNA repair without flipping out (2015) (2)
112 Structurally distinct ubiquitin- and SUMO-modified PCNA: implications for their distinct roles in the DNA damage response (2015) (2)
4 – Structural Implications for Macromolecular Recognition and Redesign (1973) (2)
Computer Graphics in the Study of Macromolecular Interactions (1987) (2)
Flexibility promotes fidelity. (2009) (2)
Mre 11 ATLD 17 / 18 mutation retains Tel 1 / ATM activity but blocks DNA double-strand break repair (2012) (2)
Charge Transport Communication through DNA by Protein Fe–S Clusters: How Far Is Not Too Far? (2019) (2)
WRN Exonuclease Structure, Molecular Mechanism, and DNA End Processing Role (2006) (2)
High Resolution Distance Distributions Determined by X-Ray and Neutron Scattering. (2017) (2)
HUMAN ERYTHROCYTE CATALASE (2000) (2)
Transcription preinitiation complex structure and dynamics provide insight into genetic diseases (2019) (2)
HUMAN DUTP PYROPHOSPHATASE (2003) (2)
CRYSTALLOGRAPHIC STRUCTURE OF PHOSPHORYLATED PILIN FROM NEISSERIA: PHOSPHOSERINE SITES MODIFY TYPE IV PILUS SURFACE CHEMISTRY (1998) (2)
Small Angle X-ray Scattering for Data-Assisted Structure Prediction in CASP12 with Prospects to Improve Accuracy (2018) (2)
Lawrence Berkeley National Laboratory Recent Work Title Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease (2)
Structural Features of DNA Glycosylases and AP Endonucleases (2005) (2)
Corrigendum: Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability (2017) (2)
Erratum: ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling (EMBO Journal (2014) 33 (482-500)) DOI 10.1002/embj.201386100 (2016) (2)
Bending Forks and Wagging Dogs--It's about the DNA 3' Tail. (2015) (1)
HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE (2000) (1)
human endothelial nitric oxide synthase with 6-nitroindazole bound (2002) (1)
Human Endothelial Nitric Oxide Synthase with 7-Nitroindazole Bound (2002) (1)
Structural Comparability Between Recombinant FVIII-Fc and Its Isolated FVIII and Fc Constituents (2012) (1)
Crystallographic structures of metalloenzymes for dna repair: The [4fe-4s] enzyme endonuclease iii structure as a prototype for dna n-glycosylase and ap lyase (1993) (1)
inducible nitric oxide synthase with 5-nitroindazole bound (2002) (1)
Cu, Zn and Mn superoxide dismutaes: Crystal structures, mutants, and function (1993) (1)
Cleavage-defective Topoisomerase I mutants sharply increase G-quadruplex-associated genomic instability (2022) (1)
human endothelial nitric oxide synthase with 5-nitroindazole bound (2002) (1)
An illustrated museum of protein structures. (1980) (1)
Faculty of 1000 evaluation for BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing. (2018) (1)
Synthesis of oligonucleotides containing 2'-fluorinated thymidine glycol as mechanism-based inhibitors of endonuclease III. (2005) (1)
A scanning-to-incision switch in TFIIH-XPG induced by DNA damage licenses nucleotide excision repair (2022) (1)
Inhibition of neutrophil migration by metal ions is a function of ion reduction potential (1984) (1)
Structural implications of BER enzymes: dragons dancing--the structural biology of DNA base excision repair. (2001) (1)
Nitric oxide synthases in motion (2012) (1)
Catalytic and Structural Effects of Amino-Acid Substitution at His30 in Human Manganese Superoxide Dismutase (2002) (1)
CRYSTAL STRUCTURE OF HUMAN URACIL-DNA GLYCOSYLASE BOUND TO UNCLEAVED SUBSTRATE-CONTAINING DNA (2000) (1)
HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE COVALENTLY CROSSLINKED TO DNA (2004) (1)
Cu, Zn and Mn superoxide dismutases; Crystal structures, mutants, and function (1993) (1)
Human XPG endonuclease catalytic domain (2020) (1)
Nickel Superoxide Dismutase (NiSOD) Apo Structure (2004) (1)
Monitoring Nuclease Activity by X-Ray Scattering Interferometry Using Gold Nanoparticle-Conjugated DNA. (2022) (1)
Vizualizing the effects of molecular flexibility on electrostatic recognition (1988) (1)
Protein engineering structure and design, prediction and evolution: cycling to success (1998) (1)
Crystal structure of S. pombe ATL1 in complex with damaged DNA containing 2,6-diaminopurine (2012) (0)
Atomicstructures ofwild-type andthermostable mutant recombinant humanCu,Znsuperoxide dismutase (1992) (0)
Human dUTP Pyrophosphatase complex with dUDP (2003) (0)
WRN exonuclease, Mn dGMP complex (2006) (0)
A condensate forming tether for lariat debranching enzyme is defective in non-photosensitive trichothiodystrophy (2022) (0)
E. coli phosphoenolpyruvate carboxykinase G209S K212C mutant bound to thiosulfate (2018) (0)
RNASE HII FROM ARCHAEOGLOBUS FULGIDUS (2001) (0)
ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE:INHIBITOR COMPLEX WITH H187D MUTANT UDG AND WILD-TYPE UGI (1999) (0)
Crystal Structure of A. Fulgidus FEN-1 bound to DNA (2004) (0)
ELECTROSTATIC FORCES BETWEEN LIGANDS AND MACROMOLECULES. (1984) (0)
Structure of human PARG complexed with JA2-9 (2019) (0)
Biochemical genetics of the mitochondrial replisome (2006) (0)
Human Exonuclease 5 crystal structure in complex with a ssDNA (2021) (0)
Structure of human PARG complexed with JA2131 (2019) (0)
MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER (DELTA 65) WITH TETRAHYDROBIOPTERIN AND PRODUCT ANALOGUE L-THIOCITRULLINE (1999) (0)
Archaellum periplasmic stator protein complex FlaF and FlaG from Sulfolobus acidocaldarius (2018) (0)
Crystal Structure of Proliferating Cell Nuclear Antigen (PCNA) from A. fulgidus (2004) (0)
Crystal Structure of Human Flap Endonuclease FEN1 (D181A) in complex with substrate 5'-flap DNA and K+ (2011) (0)
Crystal Structure Analysis of S. Pombe ATL in complex with damaged DNA containing POB (2009) (0)
HUMAN ERYTHROCYTE CATALASE 3-AMINO-1,2,4-TRIAZOLE COMPLEX (2000) (0)
CATALYTIC AND STRUCTURAL EFFECTS OF AMINO-ACID SUBSTITUTION AT HIS 30 IN HUMAN MNSOD: INSERTION OF VAL CGAMMA INTO THE SUBSTRATE ACCESS CHANNEL (2002) (0)
Flap endonuclease 1 (FEN1) R100A with 5'-flap substrate DNA and Sm3+ (2017) (0)
GFP R96M mature chromophore (2006) (0)
Y122F MUTANT OF RIBONUCLEOTIDE REDUCTASE FROM ESCHERICHIA COLI (1998) (0)
E. coli phosphoenolpyruvate carboxykinase bound to thiosulfate (2018) (0)
Incorporating HT-SAXS into drug-discovery pipelines (2020) (0)
Crystal Structure of human DNA polymerase gamma accessory subunit (2006) (0)
Crystal structure of CoV-2 Nsp3 Macrodomain (2020) (0)
High resolution crystal structure of DNA Apurinic/apyrimidinic (AP) endonuclease IV Nfo from Thermatoga maritima (2013) (0)
Proteomic Scale Small Angle X-ray Scattering (SAXS):applications and Implications (2010) (0)
Unprecedented shaping of abasic sites by DNA glycosylase homolog Mag2 from Schizosaccharomyces pombe (2013) (0)
CATALYTIC DOMAIN OF MUTY FROM ESCHERICHIA COLI D138N MUTANT (2004) (0)
Structure of S65T Y66F GFP variant after cyclization, carbon-carbon bond cleavage, and oxygen incorporation reactions (2007) (0)
X-ray Crystal Structure of an Alvinella pompejana Cu,Zn Superoxide Dismutase- Hydrogen Peroxide Complex (2009) (0)
PRELIMINARY CRYSTALLOGRAPHIC REPORTS Purification and Crystallization of a Schistosomal Glut athione S-Tr ansfer ase (1995) (0)
Crystal structure of iLOV (2012) (0)
Human Exonuclease 5 crystal structure (T88E) in complex with ssDNA and Mg (2021) (0)
Purification and Characterization of Thermotoga maritima Endonuclease IV , a Thermostable Apurinic / Apyrimidinic Endonuclease and 3 9-Repair Diesterase (1999) (0)
CATALYTIC AND STRUCTURAL EFFECTS OF AMINO-ACID SUBSTITUTION AT HIS 30 IN HUMAN MANGANESE SUPEROXIDE DISMUTASE: INSERTION OF VAL CGAMMA INTO THE SUBSTRATE ACCESS CHANNEL (2002) (0)
Structure of Archaeoglobus Fulgidis XPB (2006) (0)
Structural , functional and immunogenic insights on Cu , Zn Superoxide Dismutase pathogenic 1 virulence factors from Neisseria meningitidis and Brucella abortus 2 3 (2015) (0)
The crystal structure of a lysyl hydroxylase from Acanthamoeba polyphaga mimivirus (2018) (0)
Crystal structure of matured green fluorescent protein R96A variant (2003) (0)
THERMOTOGA MARITIMA RUVB T158V (2001) (0)
THE CRYSTAL STRUCTURE OF THE SOLUBLE DOMAIN OF SULFOLOBUS ACIDOCALDARIUS FLAF (2015) (0)
X-ray scattering methods for accurate analyses of flexible complexes (2014) (0)
The ATPase activity of BfpD is greatly enhanced by zinc and allosteric interactions with other Bfp proteins. (2009) (0)
Second binding site for a p38a kinase inhibitor (2008) (0)
Accurate mass, models and resolution for high-throughput structural analyses (2011) (0)
Structure of S65G Y66S GFP variant after spontaneous peptide hydrolysis and decarboxylation (2006) (0)
Crystal structure of the cytoplasmic domain of BfpC (2012) (0)
URACIL-DNA GLYCOSYLASE BOUND TO DNA CONTAINING A 4'-THIO-2'DEOXYURIDINE ANALOG PRODUCT (2000) (0)
Crystal Structure of Inducible Nitric Oxide Synthase with N-Nitrosated-pterin (2010) (0)
Erratum: Structural basis for endothelial nitric oxide synthase binding to calmodulin (Embo Journal (2003) 22 (766-755)) (2003) (0)
Response of the microbial metallome to arsenic stress (2012) (0)
Full-Length PAK Pilin from Pseudomonas aeruginosa (2003) (0)
HUMAN GLUTATHIONE TRANSFERASE A4-4 WITHOUT LIGANDS (1999) (0)
Crystal structure of the perchlorate reductase PcrAB from Azospira suillum PS (2016) (0)
Crystal structure of monomeric human apoptosis-inducing factor with E413A/R422A/R430A mutations (2016) (0)
Crystallization of superoxide dismutase from a halophilic organism (1996) (0)
Structure of the S. pombe Nbs1 FHA-BRCT1-BRCT2 domains (2009) (0)
Heparin-mediated dimerization of follistatin (2020) (0)
Universally Accessible Structural Data on Macromolecular Conformation, Assembly, and Dynamics by Small Angle X-Ray Scattering for DNA Repair Insights. (2022) (0)
P188. Structural insights into NOS regulatory mechanisms: What? where? how? (2006) (0)
Faculty Opinions recommendation of Contrast-matched small-angle X-ray scattering from a heavy-atom-labeled protein in structure determination: application to a lead-substituted calmodulin-peptide complex. (2013) (0)
Crystal structure of LOV2 domain of Arabidopsis thaliana phototropin 2 (2012) (0)
Interfacial residues promote an optimal alignment of the catalytic center in soluble guanylate cyclase (2014) (0)
Contribution to Structure and Catalysis of Tyrosine 34 in Human Manganese Superoxide Dismutase (2006) (0)
Crystal structure of human ABH3 in complex with iron ion and 2- oxoglutarate (2006) (0)
Crystal Structure of Human Flap Endonuclease FEN1 (WT) in complex with product 5'-flap DNA, SM3+, and K+ (2011) (0)
Crystal structure of human dim2: a dim1-like protein (2005) (0)
The total chemical synthesis of L- and D-superoxide dismutnse (1997) (0)
Inducible Nitric Oxide Synthase with 3-Bromo-7-Nitroindazole bound (2002) (0)
NIP45 SUMO-like Domain 2 (2011) (0)
Model for assembly of the Vibrio cholerae toxin co-regulated pilus (TCP) based on EM and x-ray crystallography (2003) (0)
Crystal structure of the perchlorate reductase PcrAB mutant W461E of PcrA from Azospira suillum PS (2016) (0)
Structure-Based Drug Design Targeting a Pro-Metastatic Collagen Lysyl Hydroxylase (2017) (0)
Crystal Structure of a Cu-bound Green Fluorescent Protein Zn Biosensor (2002) (0)
Crystal structure of the catalytic domain of rat poly (ADP-ribose) glycohydrolase bound to ADP-HPD (2012) (0)
Thermostable mutant of Human Superoxide Dismutase, C6A, C111S (2002) (0)
CATALYTIC DOMAIN OF MUTY FROM ESCHERICHIA COLI (1999) (0)
Reduced enolate chromophore intermediate for Y66H GFP variant (2006) (0)
Uncovering the secrets of protein interactions with the DNA enforcing genomic stability. (2017) (0)
Structure of murine iNOS oxygenase domain with inhibitor AR-C102222 (2008) (0)
structural in non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes. (2013) (0)
HUMAN APE1 ENDONUCLEASE WITH BOUND ABASIC DNA AND MN2+ ION (2000) (0)
GFP R96A chromophore maturation recovery mutant R96A Q183R (2006) (0)
E. coli phosphoenolpyruvate carboxykinase G209N mutant bound to thiosulfate (2018) (0)
HUMAN GLUTATHIONE TRANSFERASE A4-4 COMPLEX WITH IODOBENZYL GLUTATHIONE (1999) (0)
Crystal structure of TcpA, a Type IV pilin from Vibrio cholerae El Tor biotype (2010) (0)
X-RAY STRUCTURE OF A BACTERIAL COPPER,ZINC SUPEROXIDE DISMUTASE (1997) (0)
[4Fe–4S] cluster-containing human exonuclease V acts as a novel replication fork restart factor (2019) (0)
Crystal structure of S. pombe Atl1 in complex with damaged DNA containing O6-carboxymethylguanine (2012) (0)
Archaellum Assembly ATPase FlaI (2013) (0)
Crystal structure of L42H V224H design intermediate for GFP metal ion reporter (2008) (0)
METHYLATED HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE (2000) (0)
Human Exonuclease 5 crystal structure in complex with ssDNA, Sm, and Na (2021) (0)
DNA Damage: Alkylation (2013) (0)
Structure of C-terminal domain of Archaeoglobus fulgidus XPB (2006) (0)
FlaH from Sulfolobus acidocaldarius with ATP and Mg-Ion (2015) (0)
STRUCTURE OF A THERMOSTABLE THYMINE-DNA GLYCOSYLASE (2002) (0)
CRYSTAL STRUCTURE OF VIP2 WITH NAD (1999) (0)
Structure of human PARG complexed with PARG-292 (2021) (0)
A collagen glucosyltransferase drives lung adenocarcinoma progression in mice (2021) (0)
Francisella tularensis pilin PilE (2011) (0)
Crystal structure of the perchlorate reductase PcrAB - Phe164 gate switch intermediate - from Azospira suillum PS (2016) (0)
inducible nitric oxide synthase with 6-nitroindazole bound (2002) (0)
Crystal Structure of Human Flap Endonuclease FEN1 (WT) in complex with substrate 5'-flap DNA, SM3+, and K+ (2011) (0)
E. coli phosphoenolpyruvate carboxykinase K212I F216V mutant bound to methanesulfonate (2018) (0)
THE CRYSTAL STRUCTURE OF EXOENZYME C3 FROM CLOSTRIDIUM BOTULINUM (2000) (0)
Erratum: The ATPase activity of BfpD is greatly enhanced by zinc and allosteric interactions with other Bfp proteins (The Journal of Biological Chemistry (2005) vol. 280 (24839-24848)) (2009) (0)
Apoptosis-inducing factor: mechanistic insights and therapeutic opportunities from a metabolic allosteric switch (2019) (0)
Crystal Structure Analysis of S. Pombe ATL in complex with DNA (2009) (0)
Super resolution for X-ray scattering and biological insights from its applications to dynamic DNA replication and repair complexes (2017) (0)
Crystal structure of the heterodimeric catalytic domain of wild-type human soluble guanylate cyclase (2014) (0)
Mature R96K GFP mutant (2006) (0)
Crystal structure of human p38alpha MAP kinase (2009) (0)
Stress Responses as Master Keys to Epigenomic Changes in Transcriptome and Metabolome for Cancer Etiology and Therapeutics (2021) (0)
An AAA+ ATPase Clamshell Targets Transposition (2015) (0)
Catalytic Domain Of Muty From Escherichia Coli K20A Mutant (2004) (0)
Profiling human pathogenic repeat expansion regions by synergistic and multi-level impacts on molecular connections (2022) (0)
Crystal Structure of an Apo Green Fluorescent Protein Zn Biosensor (2002) (0)
Cyclized post-translational product for S65A Y66S (GFPhal) green fluorescent protein variant (2005) (0)
Nickel Superoxide Dismutase (NiSOD) Native 1.30 A Structure (2004) (0)
CKSHS1: HUMAN CYCLIN DEPENDENT KINASE SUBUNIT, TYPE 1 IN COMPLEX WITH PHOSPHATE (1996) (0)
63PClinical dysregulation of DNA repair by the polynucleotide kinase/phosphatase-XRCC4-DNA ligase IV in neurological disease (2017) (0)
Structure of a peptide derived from Cdc9 bound to PCNA (2007) (0)
Structure of the Neisseria gonorrhoeae Type IV pilus filament from x-ray crystallography and electron cryomicroscopy (2006) (0)
Crystal structure of the 26 kDa glutathione S-transferase from Schistosoma japonicum complexed with S-hexylglutathione (2003) (0)
REFINEMENT OF THE NATIVE STRUCTURE OF ENDONUCLEASE III TO A RESOLUTION OF 1.85 ANGSTROM (1995) (0)
Structure of the human apo TFIIH (2019) (0)
Dissection of DNA double-strand-break repair using novel single-molecule forceps (2018) (0)
Crystal structure of P. furiosus Mre11-H85S bound to a branched DNA and manganese (2008) (0)
Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding (2018) (0)
Modeling DNA Repair: Approaching In Vivo Techniques in the Hyperthermophile Sulfolobus Solfataricus (2005) (0)
2SA-05 The LOV/PAS-fold : what should we learn?(2SA Photobiophysics promoted by young scientists,The 49th Annual Meeting of the Biophysical Society of Japan) (2011) (0)
SUPEROXIDE DISMUTASE MUTANT WITH LYS 136 REPLACED BY GLU, CYS 6 REPLACED BY ALA AND CYS 111 REPLACED BY SER (K136E, C6A, C111S) (1999) (0)
Flexible tethering of ASPP proteins facilitates PP-1c catalysis (2019) (0)
Archaellum periplasmic stator protein FlaG from Sulfolobus acidocaldarius (2018) (0)
E. coli phosphoenolpyruvate carboxykinase Y207F mutant bound to thiosulfate and oxaloacetate (2018) (0)
Structure of the S. pombe Nbs1-Ctp1 complex (2009) (0)
Defining the Superfamily Conserved Mechanism for Flap Endonucleases FEN1 and XPG Specificity for 5' Flap DNA and DNA Bubbles, Respectively, by Hybrids Methods of Crystallography, SAXS, EM, and Computation (2014) (0)
HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE BOUND TO DNA CONTAINING O6-METHYLGUANINE (2004) (0)
Structure of human PARG complexed with PARG-131 (0)
TYR34->PHE MUTANT OF HUMAN MITOCHONDRIAL MANGANESE SUPEROXIDE DISMUTASE (1998) (0)
It takes two to tango: fine‐tuning of soluble guanylate cyclase activity via protein‐protein interactions and conformational changes (969.3) (2014) (0)
Crystal Structure of the N-terminal half of Archaeoglobus Fulgidus XPB (2006) (0)
Crystal structure of the 26 kDa glutathione S-transferase from Schistosoma japonicum complexed with gamma-glutamyl[S-(2-iodobenzyl)cysteinyl]glycine (2003) (0)
Crystal structure of native Neisseria gonorrhoeae Type IV pilin at 2.3 Angstroms Resolution (2006) (0)
Touching base with arginine: recognition of O 6 -alkyl guanines by alkyltransferase-like protein Atl1 (2014) (0)
Cyclized, non-dehydrated post-translational product for S65A Y66S H148G GFP variant (2005) (0)
CU/ZN superoxide dismutase from brucella abortus (2006) (0)
The crystal structure of the soluble domain of Sulfolobus acidocaldarius FlaF (residues 35-164) (2015) (0)
Crystal Structure of Human XLF-XRCC4 Complex (2011) (0)
Structure of human PARG complexed with PARG-002 (2021) (0)
Structure of S65T Y66F R96A GFP variant in precursor state (2007) (0)
Crystal structures of oxygenase and reductase modules of nitric oxide synthase: enzyme mechanism and regulation of electron transfer revealed (2002) (0)
Enzyme structure. Cracking tyrosine phosphatases. (1994) (0)
DNA Mismatch Repair: Minireview The Hands of a Genome Guardian (2000) (0)
Rad50 coiled-coil Zn hook (2002) (0)
Characterizing E. coli Phosphoenolpyruvate Carboxykinase Conformational States through Small Angle X-Ray Scattering (2018) (0)
X-RAY CRYSTAL STRUCTURE FOR HUMAN MANGANESE SUPEROXIDE DISMUTASE, Q143A (2000) (0)
Crystal Structure of the Discosoma Red Fluorescent Protein (DsRed) Variant K70M (2005) (0)
inducible nitric oxide synthase with 7-nitroindazole bound (2002) (0)
THERMOGOTA MARITIMA RUVB A156S MUTANT (2001) (0)
Structure of S65A Y66F GFP variant with an oxidized chromophore (2007) (0)
Defining allostery and interactions regulating apoptosis-inducing factor (2017) (0)
Flap endonuclease 1 (FEN1) D233N with cleaved product fragment and Sm3 (2017) (0)
Crystallographic structures of metalloenzymes for DNA repair: the [4Fe-4S] enzyme endonuclease III and the Mg enzyme exonuclease III (1993) (0)
Human Exonuclease 5 crystal structure (2021) (0)
Gadolinium Derivative of Tetragonal Hen Egg-White Lysozyme at 1.45 A Resolution (2014) (0)
Crystal structure of precyclized intermediate for the green fluorescent protein R96A variant (A) (2003) (0)
Distinct sequence features underlie microdeletions and gross deletions in the human genome (2021) (0)
Mre11 dimer in complex with small molecule modulator PFMJ (2020) (0)
Crystal Structure of the cyclized S65G Y66G GFP variant (2003) (0)
Coiled coils unspring protein origami (2017) (0)
CRYSTAL STRUCTURE OF THE HUMAN CDK2 KINASE COMPLEX WITH CELL CYCLE-REGULATORY PROTEIN CKSHS1 (1998) (0)
X-ray Crystal Structure of Alvinella pompejana Cu,Zn Superoxide Dismutase (2009) (0)
CRYSTAL STRUCTURE OF RAT NEURONAL NITRIC-OXIDE SYNTHASE REDUCTASE MODULE AT 2.3 A RESOLUTION. (2004) (0)
human RNF4 RING domain (2014) (0)
Murine Inducible Nitric Oxide Synthase Oxygenase Dimer (Delta 65) with W457A Mutation at Tetrahydrobiopterin Binding Site (2001) (0)
Serum albumin perturbs chemotaxis dose-inhibition profiles for 3 nonsteroidal antiinflammatory drugs (1984) (0)
Crystal Structure Analysis of Synechocystis sp. PCC6803 cryptochrome (2003) (0)
Theories about oxygen toxicity [5] (multiple letters) (1984) (0)
Nickel Superoxide Dismutase (NiSOD) CN-treated Apo Structure (2004) (0)
Crystal structure of SARS-CoV-2 Nsp3 Macrodomain complex with PARG329 (2021) (0)
Combining small angle X-ray scattering (SAXS) with protein structure predictions to characterize conformations in solution. (2023) (0)
The complimentary use of small angle x-ray scattering with crystallography in the determination of biological macromolecular structures (2008) (0)
Faculty Opinions recommendation of CRISPR-Mediated Programmable 3D Genome Positioning and Nuclear Organization. (2019) (0)
URACIL-DNA GLYCOSYLASE INHIBITOR PROTEIN (1999) (0)
Epigenetic-Metabolic Interplay in the DNA Damage Response and Therapeutic Resistance of Breast Cancer. (2023) (0)
MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER (DELTA 65) WITH SWAPPED N-TERMINAL HOOK (1999) (0)
Author Correction: Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding (2018) (0)
A novel light, oxygen, or voltage fluorescent tag for structural and biophysical analysis of DNA repair enzymes (989.1) (2014) (0)
Faculty Opinions recommendation of Structures from anomalous diffraction of native biological macromolecules. (2012) (0)
The structure of the periplasmic FlaG–FlaF complex and its essential role for archaellar swimming motility (2019) (0)
MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER (DELTA 65) WITH TETRAHYDROBIOPTERIN AND WATER BOUND IN ACTIVE CENTER (1999) (0)
Faculty Opinions recommendation of Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I. (2018) (0)
Dichelobacter nodosus pilin FimA (2011) (0)
Crystal structure of LOV2 domain of Arabidopsis thaliana phototropin 2 C426A mutant (2012) (0)
Structure of the complex of human DNA ligase III-alpha and XRCC1 BRCT domains (2020) (0)
CRYSTAL STRUCTURE OF VEGETATIVE INSECTICIDAL PROTEIN2 (VIP2) (1999) (0)
Structural characterization of reactive oxygen defence enzymes: the endonuclease IV and Y34F mutant Mn superoxide dismutase (1996) (0)
Murine inos dimer with inhibitor 4-MAP bound (2008) (0)
TO HIGH THROUGHPUT SAXS DATA COLLECTION FOR THE STUDY OF BIOLOGICAL MACROMOLECULES (2013) (0)
CATALYTIC DOMAIN OF MUTY FROM ESCHERICHIA COLI, D138N MUTANT COMPLEXED TO ADENINE (1999) (0)
Crystal structures and ribonuclease activity of the Flavivirus host factor ERI3 that is involved in viral RNA synthesis define the ERI subfamily of structure-specific 3-prime - 5-prime exoribonucleases (2021) (0)
MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER (DELTA 65) WITH TETRAHYDROBIOPTERIN AND SUBSTRATE L-ARGININE (1999) (0)
BENZYLATED HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE (2000) (0)
Shape shifting in apoptosis-inducing factor allostery and interactions: switching between oxidative phosphorylation and cell death (2018) (0)
Structure of human PARG complexed with PARG-322 (2021) (0)
Crystal Structure of S. pombe Brc1 BRCT5-BRCT6 domains (2010) (0)
Structure of human Uracil DNA Glycosylase (UDG) bound to Aurintricarboxylic acid (ATA) (2021) (0)
Robust Computational Approaches to Defining Insights on the Interface of DNA Repair with Replication and Transcription in Cancer. (2022) (0)
Mature Q183E variant of Green Fluorescent Protein Chromophore (2009) (0)
(6-4) Photolyase Crystal Structure (2009) (0)
inducible nitric oxide synthase with Chlorzoxazone bound (2002) (0)
Crystal Structure of a Zn-bound Green Fluorescent Protein Biosensor (2002) (0)
HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI DNA REPAIR ENZYME ENDONUCLEASE IV (1999) (0)
Crystal structure of the perchlorate reductase PcrAB - substrate analog SeO3 bound - from Azospira suillum PS (2016) (0)
Effects of engineering non-native ligand binding into E. coli phosphoenolpyruvate carboxykinase (2017) (0)
DNA damage response mechanisms and structures fundamental to cancer research progress. (2019) (0)
The ENIGMA Project: Mapping Protein Assemblies and Modifications by Cellular Deconstruction and Mass Spectrometry in the Hyperthermophiles Sulfolobus solfataricus, Pyrococcus furiosus, and Halobacterium NRC-1 (2010) (0)
Dancing with the elephant: structure and assembly of the fiber-forming protein pilin (1996) (0)
Crystal structure of S. pombe Atl1 in complex with damaged DNA containing O6-benzylguanine (2012) (0)
Multiscale Modeling of PCNA - Ubiquitin Interactions (2010) (0)
Structural basis for the removal and exclusion of uracil from DNA (1996) (0)
Crystal structure of the P. furiosus Rad50 ATPase domain (2001) (0)
LEUCINE-272-ALANINE URACIL-DNA GLYCOSYLASE BOUND TO ABASIC SITE-CONTAINING DNA (1999) (0)
GFP R96M pre-cyclized intermediate in chromophore formation (2006) (0)
Dim2, a new TRX-like protein implicated in cell cycle progression (2004) (0)
Structure of TcpA, the Type IV pilin subunit from the toxin co-regulated pilus of Vibrio cholerae classical biotype (2003) (0)
RNASE HII FROM ARCHAEOGLOBUS FULGIDUS WITH COBALT HEXAMMINE CHLORIDE (2001) (0)
crystal structure of KaiB from Synechocystis sp. (2005) (0)
Structure analysis of key drug design target enzymes from human pathogens (1996) (0)
Green Fluorescent Protein: Cyclized-only Intermediate of Chromophore Maturation in the Q183E variant (2009) (0)
High resolution crystal structure of Escherichia coli endonuclease IV (Endo IV) Y72A mutant bound to damaged DNA (2007) (0)
Formylglycine generating enzyme bound to copper (2019) (0)
SAXS combined with crystallography and computation: defining accurate dynamic macromolecular assemblies in solution (2009) (0)
Human apurinic/apyrimidinic endonuclease (APE1) with product DNA and Mg2+ (2013) (0)
Structure of human INOSOX with inhibitor AR-C95791 (2008) (0)
CRYSTAL STRUCTURE OF HUMAN MNSOD H30N, Y166F MUTANT (2003) (0)
C-terminal region of A. fulgidus FEN-1 complexed with A. fulgidus PCNA (2004) (0)
Transcription pre-initiation complex with TFIIH reveals transcription-ready repair-regulated helicase machine from combined cryo-EM and crystallography datasets (2019) (0)
Structure of human PARG complexed with PARG-061 (2021) (0)
human endothelial nitric oxide synthase with 3-Bromo-7-Nitroindazole bound (2002) (0)
Structure and Function of the DNA Repair Enzyme Endonuclease III (1994) (0)
A Phase‐Separating Molecular Tether for Lariat Debranching Enzyme is Defective in Non‐Photosensitive Trichothiodystrophy (2021) (0)
Nardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic Cancer (2022) (0)
MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER N-hydroxyarginine and 4-amino tetrahydrobiopterin (2000) (0)
CRYSTAL STRUCTURE OF ESCHERICHIA COLI ENDONUCLEASE IV IN COMPLEX WITH DAMAGED DNA (1999) (0)
FEN-1 FROM P. FURIOSUS (2000) (0)
Dismutase Superoxide Interface of Human Manganese Amino Acid Substitution at the Dimeric Enzyme Catalysis and Regulation (2014) (0)
Uncyclized precursor structure of S65A Y66S G67A GFP variant (2005) (0)
REDUCED BRIDGE-BROKEN YEAST CU/ZN SUPEROXIDE DISMUTASE ROOM TEMPERATURE (298K) STRUCTURE (1996) (0)
HP1β Chromo Shadow Domain facilitates H2A ubiquitination for BRCA1 recruitment at DNA double-strand breaks (2022) (0)
Crystal structure of endothelial nitric oxide synthase peptide bound to calmodulin (2003) (0)
The renaissance in biophysics and molecular biology enabled by the interface of DNA repair and replication with cancer. (2021) (0)
THERMOTOGA MARITIMA RUVB HOLLIDAY JUNCTION BRANCH MIGRATION MOTOR (2001) (0)
HUMAN ERYTHROCYTE CATALSE CYANIDE COMPLEX (2000) (0)
Structure of Human Cu,Zn Superoxide Dismutase (2003) (0)
Studies towards the X-ray crystal structure of helicases (1996) (0)
Faculty of 1000 evaluation for The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport. (2018) (0)
Structure of human PARG complexed with PARG-119 (2021) (0)
Mre11 dimer in complex with Endonuclease inhibitor PFM04 (2018) (0)
Structural basis for endothelial nitric oxide synthase binding to calmodulin (2013) (0)
204 Structural insights into the RAD51 paralog complexes reveal molecular details of disease causing mutations (2015) (0)
MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DOMAIN (DELTA 114), IMIDAZOLE COMPLEX (1998) (0)
Crystal structure of the archaeal secretion ATPase GspE in complex with phosphate (2007) (0)
MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DOMAIN (DELTA 114) COMPLEXED WITH TYPE I E. COLI CHLORAMPHENICOL ACETYL TRANSFERASE AND IMIDAZOLE (1998) (0)
RIBONUCLEOTIDE REDUCTASE R2 SUBUNIT FROM E. COLI (1998) (0)
Structure of the C-terminal BRCT domain of human XRCC1 (2020) (0)
Abstract 1394: Advanced computational modeling of molecular machines involved in transcription initiation and DNA repair (2023) (0)
Crystal structure of phiLOV2.1 (2012) (0)
Accurate Structures, Conformations, and Assemblies of Macromolecules in Solution by X-Ray Scattering (SAXS) using Quality Control Parameters (2012) (0)
WILD-TYPE URACIL-DNA GLYCOSYLASE BOUND TO URACIL-CONTAINING DNA (1999) (0)
Crystal structure of human apoptosis-inducing factor with W196A mutation (2016) (0)
Crystal structure of the human CU, Zn Superoxide Dismutase, Familial Amyotrophic Lateral Sclerosis (FALS) Mutant H43R (2003) (0)
High Resolution crystal structure of Escherichia coli endonuclease IV (Endo IV) E261Q mutant (2007) (0)
Amino acid hydrophobicity in the context of folded proteins: A crystallographic hydration scale (1993) (0)
SAXS and macromolecular crystallography at the SIBYLS beamline (12.3.1) of the Advanced Light Source (2008) (0)
E. coli phosphoenolpyruvate carboxykinase G209S mutant bound to methanesulfonate (2018) (0)
P0118. Structural insights into the conformational selectivity of inducible nitric oxide synthase specific inhibitors (2006) (0)
Optimizing small molecules as a chemical tool to control DNA repair enzymes using X-ray crystallography and computational techniques (2018) (0)
Dynamics of the DYNLL1/MRE11 complex regulates DNA end resection and recruitment of the Shieldin complex to DSBs (2023) (0)
Structure of human PARG complexed with JA2-8 (2019) (0)
Structure of human PARG complexed with JA2-4 (2019) (0)
The hexameric structures of the archeal secretion ATPase revealed by X-ray crystallography and SAXS (2008) (0)
Applying HT-SAXS to chemical ligand screening. (2023) (0)
WORKSHOP 3: Applications of Small Angle X-Ray Scattering (2011) (0)
Mre11 dimer in complex with small molecule modulator PFMI (2020) (0)
Rad60 SLD2 Ubc9 Complex (2011) (0)
THERMOTOGA MARITIMA RUVB K64R MUTANT (2001) (0)
Identification of unique α4 chain structure and conserved anti-angiogenic activity of α3NC1 type IV collagen in zebrafish (2023) (0)
Structure of inhibited murine iNOS oxygenase domain (2008) (0)
Crystal structure of P. furiosus Mre11 with manganese and dAMP (2001) (0)
C-terminal region of FEN-1 bound to A. fulgidus PCNA (2004) (0)
Anaerobic precylization intermediate crystal structure for S65G Y66G GFP variant (2003) (0)
Crystal structure of Escherichia coli endonuclease IV (Endo IV) E261Q mutant bound to damaged DNA (2007) (0)
Faculty Opinions recommendation of Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair. (2018) (0)
EXPRESSION, PURIFICATION, AND SMALL ANGLE X-RAY SCATTERING OF DNA REPLICATION AND REPAIR PROTEINS FROM THE HYPERTHERMOPHILE SULFOLOBUS SOLFATARICUS (2008) (0)
Crystal structure of the catalytic domain of rat poly (ADP-ribose) glycohydrolase (2012) (0)
Crystal structure of CoV-2 Nsp3 Macrodomain complex with PARG345 (2021) (0)
CRYSTAL STRUCTURE OF THE CELL CYCLE REGULATORY PROTEIN CKS1 (2000) (0)
NEUTRALISING MUTATIONS OF CARBOXYLATES THAT BIND METAL 2 IN T 5 FEN RESULT IN AN ENZYME THAT STILL HAS A TWO METAL ION REQUIREMENT (2014) (0)
Crystal Structure Analysis of S. Pombe ATL (2009) (0)
Archaellum Assembly ATPase FlaI bound to ADP (2013) (0)
YEAST CU, ZN SUPEROXIDE DISMUTASE WITH THE REDUCED BRIDGE BROKEN (1996) (0)
human endothelial nitric oxide synthase with chlorzoxazone bound (2002) (0)
MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DOMAIN (DELTA 114), AMINOGUANIDINE COMPLEX (1998) (0)
Cyclized-Dehydrated Intermediate of GFP Variant Q183E in Chromophore Maturation (2009) (0)
Characterizations of intracellular arsenic in a bacterium (2011) (0)
MURINE INOSOXY DIMER WITH ISOTHIOUREA BOUND IN THE ACTIVE SITE (1999) (0)
CRYSTAL STRUCTURE OF HUMAN APE1 BOUND TO ABASIC DNA (2000) (0)
HUMAN URACIL-DNA GLYCOSYLASE (1997) (0)
Crystal structure of the 26 kDa glutathione S-transferase from Schistosoma japonicum complexed with glutathione sulfonic acid (2003) (0)
CKSHS1: HUMAN CYCLIN DEPENDENT KINASE SUBUNIT, TYPE 1 COMPLEX WITH METAVANADATE (1996) (0)
Crystal Structure of S. pombe Brc1 BRCT5-BRCT6 domains in complex with phosphorylated H2A (2010) (0)
The crystal structure of a collagen galactosylhydroxylysyl glucosyltransferase from human (2021) (0)
Crystal structure of P. furiosus Mre11 DNA synaptic complex (2008) (0)
HETE: New Observations (1975) (0)
Structure of S65A Y66F E222A GFP variant after cyclization and carbon-carbon bond cleavage (2007) (0)
High Resolution Crystal Structure of the Discosoma Red Fluorescent Protein (DsRed) (2005) (0)
Structure of the HSOD A4V mutant (2002) (0)
The crystal structure of inducible nitric oxide synthase oxygenase domain dimer with L-arginine and tetrahydrobiopterin (1999) (0)
Constitutively zinc-deficient mutant of human superoxide dismutase (SOD), C6A, H80S, H83S, C111S (2007) (0)

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John A. Tainer is affiliated with the following schools:

Duke University
Monash University
University of California, Berkeley
University of Waterloo
Oregon State University
MD Anderson Cancer Center
California Institute of Technology
Concordia University
University of Florida
University of Missouri
University of Guelph
Stanford University

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