John W. Sedat
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John W. Sedatbiology Degrees
Biology
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Genetics
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Molecular Biology
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Biology
John W. Sedat's Degrees
- PhD Biochemistry University of California, Berkeley
- Bachelors Chemistry University of California, Berkeley
Why Is John W. Sedat Influential?
(Suggest an Edit or Addition)John W. Sedat's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Spatial partitioning of the regulatory landscape of the X-inactivation centre (2012) (2436)
- Three-dimensional resolution doubling in wide-field fluorescence microscopy by structured illumination. (2008) (1290)
- Subdiffraction Multicolor Imaging of the Nuclear Periphery with 3D Structured Illumination Microscopy (2008) (1063)
- Fluorescence microscopy: reduced photobleaching of rhodamine and fluorescein protein conjugates by n-propyl gallate. (1982) (826)
- Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. (2000) (759)
- Fluorescence microscopy in three dimensions. (1989) (700)
- Interphase chromosomes undergo constrained diffusional motion in living cells (1997) (638)
- Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. (2001) (560)
- Mitochondrial transmission during mating in Saccharomyces cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mitochondrial DNA. (1997) (505)
- Microtubule nucleation by γ-tubulin-containing rings in the centrosome (1995) (496)
- Perturbation of Nuclear Architecture by Long-Distance Chromosome Interactions (1996) (433)
- Three-dimensional architecture of a polytene nucleus (1983) (416)
- Mitosis in living budding yeast: anaphase A but no metaphase plate. (1997) (399)
- Direct Evidence of a Role for Heterochromatin in Meiotic Chromosome Segregation (1996) (374)
- Telomeres Cluster De Novo before the Initiation of Synapsis: A Three-dimensional Spatial Analysis of Telomere Positions before and during Meiotic Prophase (1997) (297)
- The use of a charge-coupled device for quantitative optical microscopy of biological structures. (1987) (297)
- Spatial control of actin polymerization during neutrophil chemotaxis (1999) (286)
- Spatial organization of chromosomes in the salivary gland nuclei of Drosophila melanogaster (1986) (275)
- Localization of antigenic determinants in whole Drosophila embryos. (1983) (262)
- Multiple regimes of constrained chromosome motion are regulated in the interphase Drosophila nucleus (2001) (261)
- Time-Lapse Microscopy Reveals Unique Roles for Kinesins during Anaphase in Budding Yeast (1998) (256)
- A direct approach to the structure of eukaryotic chromosomes. (1978) (250)
- Determination of three-dimensional imaging properties of a light microscope system. Partial confocal behavior in epifluorescence microscopy. (1990) (248)
- Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. (1999) (241)
- UCSF tomography: an integrated software suite for real-time electron microscopic tomographic data collection, alignment, and reconstruction. (2007) (227)
- Specific interactions of chromatin with the nuclear envelope: positional determination within the nucleus in Drosophila melanogaster. (1996) (224)
- The three-dimensional architecture of chromatin in situ: electron tomography reveals fibers composed of a continuously variable zig-zag nucleosomal ribbon (1994) (223)
- Three-dimensional structural characterization of centrosomes from early Drosophila embryos (1995) (217)
- Enteropathogenic E. coli acts through WASP and Arp2/3 complex to form actin pedestals (1999) (214)
- Block in Anaphase Chromosome Separation Caused by a Telomerase Template Mutation (1997) (205)
- The absence of detectable methylated bases in Drosophila melanogaster DNA (1982) (201)
- The onset of homologous chromosome pairing during Drosophila melanogaster embryogenesis (1993) (199)
- Microtubule nucleation by gamma-tubulin-containing rings in the centrosome. (1995) (194)
- Homologous Chromosome Pairing in Drosophila melanogaster Proceeds through Multiple Independent Initiations (1998) (191)
- Interphase nuclear envelope lamins form a discontinuous network that interacts with only a fraction of the chromatin in the nuclear periphery (1990) (188)
- Automated microscopy for electron tomography. (1992) (183)
- A three-dimensional approach to mitotic chromosome structure: evidence for a complex hierarchical organization (1987) (182)
- Multiple chromosomal populations of topoisomerase II detected in vivo by time-lapse, three-dimensional wide-field microscopy (1993) (178)
- N-terminal processing of proteins exported by malaria parasites. (2008) (177)
- Fast live simultaneous multiwavelength four-dimensional optical microscopy (2010) (177)
- Characteristic folding pattern of polytene chromosomes in Drosophila salivary gland nuclei (1984) (175)
- A Presynaptic Giant Ankyrin Stabilizes the NMJ through Regulation of Presynaptic Microtubules and Transsynaptic Cell Adhesion (2008) (170)
- Evidence for the coincident initiation of homolog pairing and synapsis during the telomere-clustering (bouquet) stage of meiotic prophase. (2000) (165)
- Sevenfold improvement of axial resolution in 3D wide-field microscopy using two objective lenses (1995) (162)
- The Dynamics of Homologous Chromosome Pairing during Male Drosophila Meiosis (2002) (162)
- Meiotic chromosome pairing in maize is associated with a novel chromatin organization (1994) (153)
- I5S: wide-field light microscopy with 100-nm-scale resolution in three dimensions. (2008) (151)
- Phase‐retrieved pupil functions in wide‐field fluorescence microscopy (2004) (146)
- IVE (Image Visualization Environment): a software platform for all three-dimensional microscopy applications. (1996) (144)
- Three-dimensional multiple-wavelength fluorescence microscopy for the structural analysis of biological phenomena. (1991) (134)
- Chest wall invasion by bronchogenic carcinoma: evaluation with MR imaging. (1993) (132)
- Doubling the lateral resolution of wide-field fluorescence microscopy using structured illumination (2000) (123)
- Drosophila gastrulation: analysis of cell shape changes in living embryos by three-dimensional fluorescence microscopy. (1991) (121)
- Drosophila nuclear lamin precursor Dm0 is translated from either of two developmentally regulated mRNA species apparently encoded by a single gene [published erratum appears in J Cell Biol 1988 Jun;106(6):2225] (1988) (120)
- Three-dimensional organization of Drosophila melanogaster interphase nuclei. I. Tissue-specific aspects of polytene nuclear architecture (1987) (119)
- An improved strategy for automated electron microscopic tomography. (2004) (117)
- Three-dimensional organization of Drosophila melanogaster interphase nuclei. II. Chromosome spatial organization and gene regulation (1987) (116)
- Large-scale chromatin structural domains within mitotic and interphase chromosomes in vivo and in vitro (1989) (109)
- Direct cell lineage analysis in Drosophila melanogaster by time-lapse, three-dimensional optical microscopy of living embryos (1989) (108)
- Deconstructing the nucleus: global architecture from local interactions. (1997) (106)
- Focal points for chromosome condensation and decondensation revealed by three-dimensional in vivo time-lapse microscopy (1989) (106)
- Chromosome elasticity and mitotic polar ejection force measured in living Drosophila embryos by four-dimensional microscopy-based motion analysis (2001) (105)
- Computational adaptive optics for live three-dimensional biological imaging (2001) (105)
- The Mcp element mediates stable long-range chromosome-chromosome interactions in Drosophila. (2006) (104)
- Dispersion, aberration and deconvolution in multi‐wavelength fluorescence images (1996) (104)
- Tilted view reconstruction in optical microscopy. Three-dimensional reconstruction of Drosophila melanogaster embryo nuclei. (1989) (101)
- Temporal and spatial coordination of chromosome movement, spindle formation, and nuclear envelope breakdown during prometaphase in Drosophila melanogaster embryos (1990) (99)
- Chapter 16 Solid-State Imagers for Microscopy (1988) (98)
- Direct determination of DNA nucleotide sequences: structure of a fragment of bacteriophage phiX172 DNA. (1974) (93)
- Rapid isolation of metaphase chromosomes containing high molecular weight DNA (1979) (91)
- High-resolution soft x-ray microscopy. (1977) (91)
- The Collection, Processing, and Display of Digital Three-Dimensional Images of Biological Specimens (1995) (90)
- Deconvolution in optical microscopy (1996) (86)
- Phase Behavior of Ordered Diblock Copolymer Blends: Effect of Compositional Heterogeneity (1996) (85)
- Phase retrieval for high-numerical-aperture optical systems. (2003) (84)
- Whole cell imaging reveals novel modular features of the exomembrane system of the malaria parasite, Plasmodium falciparum. (2010) (84)
- Toward fully automated high-resolution electron tomography. (1996) (84)
- Condensed Mitotic Chromosome Structure at Nanometer Resolution Using PALM and EGFP- Histones (2010) (82)
- Precise determination of the molecular limits of a polytene chromosome band: Regulatory sequences for the Notch gene are in the interband (1988) (82)
- AIDA: an adaptive image deconvolution algorithm with application to multi-frame and three-dimensional data. (2007) (81)
- Cryo automated electron tomography: Towards high‐resolution reconstructions of plastic‐embedded structures (1994) (76)
- Fractionation of nucleic acid on benzoylated-naphthoylated DEAE cellulose. (1967) (74)
- Time-resolved, in vivo studies of mitotic spindle formation and nuclear lamina breakdown in Drosophila early embryos. (1996) (74)
- High-performance iterative electron tomography reconstruction with long-object compensation using graphics processing units (GPUs). (2010) (74)
- On the efficiency of iterative ordered subset reconstruction algorithms for acceleration on GPUs (2010) (67)
- Proteins shifting from the cytoplasm into the nuclei during early embryogenesis of Drosophila melanogaster. (1984) (67)
- High‐resolution wide‐field microscopy with adaptive optics for spherical aberration correction and motionless focusing (2010) (66)
- High-resolution restoration of 3D structures from widefield images with extreme low signal-to-noise-ratio (2013) (65)
- Microstructural Analysis of a Cubic Bicontinuous Morphology in a Neat SIS Triblock Copolymer (1997) (61)
- Modelling the application of adaptive optics to wide‐field microscope live imaging (2007) (61)
- Solid-state imagers for microscopy. (1989) (60)
- Rapid telomere motions in live human cells analyzed by highly time-resolved microscopy (2008) (60)
- Cell-by-Cell Dissection of Gene Expression and Chromosomal Interactions Reveals Consequences of Nuclear Reorganization (2005) (55)
- Mapping three-dimensional chromosome architecture in situ. (1998) (55)
- Manipulation, Display, and Analysis of Three-Dimensional Biological Images (1990) (52)
- Spatial Organization of the Drosophila Nucleus: A Three-Dimensional Cytogenetic Study (1984) (52)
- Two proteins that cycle asynchronously between centrosomes and nuclear structures: Drosophila CP60 and CP190. (1997) (51)
- Purification of Escherichia coli pulse-labeled RNA by benzoylated DEAE-cellulose chromatography. (1969) (51)
- Determination of the nucleotide sequence of a fragment of bacteriophage phiX 174 DNA. (1973) (51)
- The three-dimensional structure of in vitro reconstituted Xenopus laevis chromosomes by EM tomography (2007) (50)
- 11 Cytology of Telomeres (1995) (47)
- Structure of the DNA of bacteriophage FX174V. Purine sequences (1964) (45)
- Nuclear structure: determination of the fate of the nuclear envelope in Drosophila during mitosis using monoclonal antibodies. (1983) (44)
- OMX: a new platform for multimodal, multichannel wide-field imaging. (2011) (43)
- A Parallel Product-Convolution approach for representing the depth varying Point Spread Functions in 3D widefield microscopy based on principal component analysis. (2010) (43)
- Structure of the DNA of bacteriophage phiX174. VII. Methylation. (1970) (43)
- Long-range interphase chromosome organization in Drosophila: a study using color barcoded fluorescence in situ hybridization and structural clustering analysis. (2004) (39)
- A three-dimensional structural dissection of Drosophila polytene chromosomes (1995) (34)
- PRIISM: an integrated system for display and analysis of 3-D microscope images (1992) (34)
- Design and construction of an optimal illumination system for quantitative wide‐field multi‐dimensional microscopy (1993) (34)
- Gene F of bacteriophage phiX174. Correlation of nucleotide sequences from the DNA and amino acid sequences from the gene product. (1976) (33)
- 3D widefield microscopy with two objective lenses: experimental verification of improved axial resolution (1996) (32)
- Three-Dimensional Microscopy: Image Processing For High Resolution Subcellular Imaging (1989) (31)
- Effect of depth dependent spherical aberrations in 3D structured illumination microscopy. (2012) (30)
- CryoSIM: super-resolution 3D structured illumination cryogenic fluorescence microscopy for correlated ultrastructural imaging (2020) (29)
- The three-dimensional organization of polytene nuclei in male Drosophila melanogaster with compound XY or ring X chromosomes. (1989) (29)
- Analysis of 5-methylcytosine in DNA. I. Mass spectrometry. (1976) (29)
- Closed loop adaptive optics for microscopy without a wavefront sensor (2010) (28)
- Descending necrotizing mediastinitis: a rare pathology to keep in mind. (2005) (28)
- Selective loss of sperm bearing a compound chromosome in the Drosophila female. (1996) (27)
- Evidence of Activity-Specific, Radial Organization of Mitotic Chromosomes in Drosophila (2011) (25)
- A library of monoclonal antibodies to nuclear proteins from Drosophila melanogaster embryos. Characterization by a cultured cell assay. (1982) (24)
- Architecture-induced phase immiscibility in a diblock/multiblock copolymer blend (1996) (24)
- Automated data collection for electron microscopic tomography. (2010) (23)
- Structure of Drosophila polytene chromosomes. Evidence for a toroidal organization of the bands. (1982) (23)
- A novel 3D wavelet‐based filter for visualizing features in noisy biological data (2005) (22)
- Anatomical study of the temporal lobe. Correlations with nuclear magnetic resonance. (1990) (22)
- Orientation of the Complementary Strands of Polyoma Virus DNA with Respect to the DNA Physical Map (1976) (21)
- Wavelet-based characterization of vertebral trabecular bone structure from magnetic resonance images at 3 T compared with micro-computed tomographic measurements. (2007) (21)
- Light microscope based analysis of three‐dimensional structure: Applications to the study of Drosophila salivary gland nuclei. I. Data collection and analysis (1985) (20)
- SOFT X‐RAY LITHOGRAPHIC STUDIES OF INTERPHASE CHROMOSOMES (1980) (20)
- Chromosome structure inside the nucleus. (1993) (20)
- Mechanism of image formation for thick biological specimens: exit wavefront reconstruction and electron energy‐loss spectroscopic imaging (1995) (19)
- Three‐dimensional microscopy in thick biological samples: A fresh approach for adjusting focus and correcting spherical aberration (1997) (19)
- GRAMICIDIN S MESSENGER RNA. I. ISOLATION AND CHARACTERIZATION. (1965) (17)
- Solution of Toeplitz systems for the restoration of 3-D optical-sectioning microscopy data (1990) (17)
- Automated acquisition of electron microscopic random conical tilt sets. (2007) (17)
- A distributed multi-GPU system for high speed electron microscopic tomographic reconstruction. (2011) (16)
- Analysis of 5-methylcytosine in DNA. II. Gas chromatography. (1977) (14)
- Three-Dimensional Analysis of Biological Specimens Utilizing Image Processing Techniques (1980) (14)
- Practical image restoration of thick biological specimens using multiple focus levels in transmission electron microscopy. (1997) (13)
- Dual-axis target mapping and automated sequential acquisition of dual-axis EM tomographic data. (2009) (13)
- Optimal strategies for imaging thick biological specimens: exit wavefront reconstruction and energy‐filtered imaging (1996) (12)
- Aneurysm of the superior mesenteric vein. (1993) (11)
- The in vivo ϕX mRNA (1970) (11)
- Three-dimensional light microscopy of diploid Drosophila chromosomes. (1988) (11)
- Three-dimensional deconvolution processing for STEM cryotomography (2020) (11)
- Direct determination of DNA nucleotide sequences. Structure of large specific fragments of bacteriophage phiX174 DNA. (1976) (10)
- From Micelles to Randomly Connected, Bilayered Membranes in Dilute Block Copolymer Blends (1997) (10)
- In vivo methylation of replicating bacteriophage φX174 DNA (1973) (9)
- An extended view of nuclear lamin structure, function, and dynamics. (1992) (9)
- GRAMICIDIN S MESSENGER RNA. II. PHYSICAL AND CHEMICAL PROPERTIES. (1965) (8)
- Microscope-Cockpit: Python-based bespoke microscopy for bio-medical science (2021) (8)
- Analysis of Three-Dimensional Image Data: Display and Feature Tracking (1992) (8)
- Entropy-regularized deconvolution of cellular cryotransmission electron tomograms (2021) (7)
- Wavelet Based Characterization of Vertebral Trabecular Bone Structure from MR Images of Specimen at 3 Tesla Compared to MicroCT Measurements (2005) (6)
- Three-dimensional organization of chromosomes studied by in-situ hybridization and optical-sectioning microscopy (1990) (6)
- Arterioportal fistula after transjugular intrahepatic portosystemic shunt placement. (1995) (6)
- Performance Evaluation of a Transmission Scintillator-Based Lens-Coupled 4K CCD Camera for Use in Low-Dose Electron Cryo-Tomography (2004) (6)
- Fluorescence microscopy without resolution limit (2004) (5)
- Magnetic resonance imaging of von Meyenburg complexes: report of a pathologically documented case. (1994) (5)
- Transjugular needle biopsy of the liver with an automated core biopsy set. (1997) (4)
- Phase retrieval of widefield microscopy point spread functions (2001) (4)
- Applying adaptive optics to three-dimensional wide-field microscopy (2008) (4)
- [Kaposi sarcoma of the lungs in patients with acquired immunodeficiency syndrome (AIDS). Thoracic radiography and scanning]. (1993) (3)
- Three-Dimensional reconstruction of the synaptonemal complex from high-pressure frozen maize meiocytes using IVEM Tomography (1994) (3)
- Reply to Letter to the Editor (2007) (3)
- In vivo methylation of replicating bacteriophage phi chi174 DNA. (1973) (2)
- Nuclear architecture. (1999) (2)
- Approaches for High Resolution Cryo-Electron Tomography of Biological Specimens (1997) (2)
- Percutaneous Infiltrations of Cervical, Thoracic, and Lumbar Spine (2002) (2)
- A proposed unified interphase nucleus chromosome structure: Preliminary preponderance of evidence (2021) (2)
- Adaptive optics in wide-field microscopy (2011) (2)
- Motion estimation and visualization for four-dimensional optical microscopy (1994) (2)
- Application of phase-retrieved pupil functions in wide-field fluorescence microscopy (2002) (2)
- Three-dimensional fluorescence microscopy for the analysis of spatial arrangement of chromosomes (1991) (2)
- Spatial arrangement of homologous chromosomes during anaphase in early embryos of Drosophila melanogaster studied by three-dimensional fluorescence microscopy (1997) (1)
- Sub-100nm Axial Resolution in 3D Widefield Optical Microscopy Using Two Opposing Objective Lenses (1997) (1)
- [1,5 Tesla MRI in focal nodular hyperplasia. Review of the literature apropos of 7 cases]. (1994) (1)
- Automated data collection for electron tomography (1992) (1)
- Automated Acquisition of Tomographic and Random Conical Tilt Series and Real-time Reconstruction Using UCSF Tomography (2006) (1)
- A proposed unified mitotic chromosome architecture (2021) (1)
- Quantitative analysis of chromosome motion in Drosophila melanogaster (1995) (1)
- New Insights Into the Three-Dimensional Structure of the Nucleus and Chromosomes (1997) (1)
- An Epigenetic Role for Maternally Inherited piRNAs in Transposon Silencing (2008) (1)
- Successive assembly of two proteins onto the centrosome coordinated with specific events during mitosis (1994) (0)
- [Cystic dilatation of the seminal vesicle associated with renal agenesis. Contribution of different types of imaging]. (1993) (0)
- The Onset of Homologous Chromosome Pairing (2002) (0)
- Whole Cell Imaging of Plasmodium Falciparum Blood Stages (2009) (0)
- Regularized Reconstruction of Nonnegative Images Degraded by a Point-spread Function with a Band-limited Transfer Function (1989) (0)
- STRUCTURE OF THE DNA OF BACTERIOPHAGE PHI-X174. V. PURINE SEQUENCES. (1964) (0)
- On Bacterial and ØX-174 Messenger-RNA (1971) (0)
- Imagerie adaptative informatisee (1999) (0)
- S09-04 OMX, a new microscope platform for increased time and spatial resolution (2009) (0)
- Phase Behavior of Complex Diblock Copolymer Blends: A Transmission Electron Microscopy Study (1997) (0)
- An algorithm for estimation of chromosome motion in Four-Dimensional microscopic images (1994) (0)
- Wavelet Algorithm for Feature Identification and Image Analysis (2005) (0)
- High resolution restoration of 3 D structures from extreme low dose widefield images (2012) (0)
- Three-dimensional Optical Microscopy of Biological Specimens (1986) (0)
- Embryonic lineage analysis using three-dimensional, time-lapse in-vivo fluorescent microscopy (1990) (0)
- CONSTRAINTS UPON CHROMOSOME ORGANIZATION IN ANEUPLOID CNS CELLS (1978) (0)
- Five-Dimensional Microscopy using Widefield-Deconvolution: Practical Considerations and Biological Applications (1996) (0)
- Marker with a variety of shades (1999) (0)
- Software And Hardware For 3-D Gray Level Image Analysis And Quantization (1989) (0)
- Chromosome mechanics in vivo: quantitative analysis of nonrigid 3D chromosome motion in Drosophila embryos (1996) (0)
- Estimation and analysis of 3-D chromosome motion (1995) (0)
- 3D Deconvolution Processing for STEM Cryo-Tomography (2020) (0)
- High resolution IVEM tomography of biological specimens (1997) (0)
- 3D Deconvolution for Cryo-Scanning Transmission Electron Tomography (2017) (0)
- Supplementary document for CryoSIM: super resolution 3D structured illumination cryogenic fluorescence microscopy for correlated ultra-structural imaging - 4631682.pdf (2020) (0)
- Orientation oftheComplementary Strands ofPolyoma Virus DNA withRespect totheDNA Physical Map (1976) (0)
- Wavelet based characterization of ex vivo vertebral trabecular bone structure with 3T MRI compared to microCT (2005) (0)
- [Giant bronchopyocele. General and radiological characteristics. Apropos of a case]. (1995) (0)
- Image reconstruction using a focus series on thick biological specimens: TEM CTF correction (1993) (0)
- Serial Acquisition of Dual Axis EM Tomographic Data (2008) (0)
- Spinal Infiltrations: Technical Difficulties and Potential Complications (2007) (0)
- Structure of Centrosomes and Chromosomes Through IVEM Tomography (1997) (0)
- Process for the preparation of fluorinated compounds olefinic (2009) (0)
- Homologous DNA Interactions in Interphase: Spatial Organization of Interphase Nucleus (2001) (0)
- These references are cited in the additional data files. (2012) (0)
- Lothar Schermelleh , Microscopy Periphery with 3 D Structured Illumination Subdiffraction Multicolor Imaging of the Nuclear (2008) (0)
- Brain Stem Anatomy and MRI (1989) (0)
- Structure and function relationships—The diploid nucleus of Drosophila (1989) (0)
- Lothar Schermelleh Structured Illumination Microscopy Subdiffraction Multicolor Imaging of the Nuclear Periphery with 3 D (2012) (0)
- Chromosome structure and dynamics as revealed by 3-D and 4-D imaging (1991) (0)
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