Jonathan Baell

Q: What Schools Are Affiliated With Jonathan Baell

Jonathan Baell is affiliated with the following schools: Monash University, Nanjing Tech University, Nanjing Normal University, University of Melbourne

Jonathan Baell's AcademicInfluence.com Rankings

Jonathan Baell

Chemistry

#3518

World Rank

#4540

Historical Rank

Organic Chemistry

#857

World Rank

#959

Historical Rank

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Chemistry

Why Is Jonathan Baell Influential?

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According to Wikipedia, Jonathan Baell is trained as an Australian medicinal chemist and is currently executive director, early leads chemistry at Lyterian Therapeutics in San Francisco. Prior to this, he was a research professor in medicinal chemistry at the Monash Institute of Pharmaceutical Sciences , the director of the Australian Translational Medicinal Chemistry Facility and a Chief Investigator at the ARC Centre for Fragment-Based Design. He was President of the International Chemical Biology Society 2018-2021 and is currently chair of the board. His research focuses on the early stages of drug discovery, including high-throughput screening library design, hit-to-lead and lead optimization for the treatment of a variety of diseases, such as malaria and neglected diseases.

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Jonathan Baell's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. (2010) (2670)
Chemistry: Chemical con artists foil drug discovery (2014) (817)
The promise and peril of chemical probes. (2015) (623)
Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS). (2016) (354)
Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs (2013) (350)
Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations (2017) (335)
Structure-guided design of a selective BCL-X(L) inhibitor. (2013) (314)
FAF-Drugs3: a web server for compound property calculation and chemical library design (2015) (237)
Observations on screening-based research and some concerning trends in the literature. (2010) (157)
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth (2018) (147)
Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs. (2002) (141)
Defining the Mechanisms by Which the Reactive Oxygen Species By-Product, 4-Hydroxynonenal, Affects Human Sperm Cell Function1 (2015) (113)
KNIME Workflow to Assess PAINS Filters in SMARTS Format. Comparison of RDKit and Indigo Cheminformatics Libraries (2011) (108)
Low cost whole-organism screening of compounds for anthelmintic activity. (2015) (102)
The FAF-Drugs2 server: a multistep engine to prepare electronic chemical compound collections (2011) (87)
HBO1 is required for the maintenance of leukaemia stem cells (2019) (74)
Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors (2017) (73)
Identification of Compounds with Anti-Proliferative Activity against Trypanosoma brucei brucei Strain 427 by a Whole Cell Viability Based HTS Campaign (2012) (73)
Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles (2015) (70)
Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation (2018) (69)
Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold. (2015) (68)
PAINS: Relevance to Tool Compound Discovery and Fragment-Based Screening (2013) (64)
Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity. (2011) (61)
Phosphate isosteres in medicinal chemistry. (2005) (60)
Established and emerging trends in computational drug discovery in the structural genomics era. (2012) (59)
Broad Coverage of Commercially Available Lead-like Screening Space with Fewer than 350, 000 Compounds (2013) (58)
Trypanothione Reductase High-Throughput Screening Campaign Identifies Novel Classes of Inhibitors with Antiparasitic Activity (2009) (56)
Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL. (2013) (55)
Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity. (2013) (55)
Khellinone derivatives as blockers of the voltage-gated potassium channel Kv1.3: synthesis and immunosuppressive activity. (2004) (52)
Design and synthesis of type-III mimetics of ω-conotoxin GVIA (2001) (52)
Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei. (2014) (51)
Synthesis and biological evaluation of nonpeptide mimetics of ω-conotoxin GVIA (2004) (51)
Screening-based translation of public research encounters painful problems. (2015) (50)
An Efficient High-Throughput Screening Method for MYST Family Acetyltransferases, a New Class of Epigenetic Drug Targets (2011) (45)
Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation. (2019) (44)
Effects of modulators of Ca2+‐activated, intermediate‐conductance potassium channels on motility of the rat small intestine, in vivo (2007) (44)
LIM kinase inhibition reduces breast cancer growth and invasiveness but systemic inhibition does not reduce metastasis in mice (2013) (43)
Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors). (2007) (43)
Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening. (2007) (43)
3-alkylthio-1,2,4-triazine dimers with potent antimalarial activity. (2010) (43)
Sites of action of ghrelin receptor ligands in cardiovascular control. (2012) (42)
Inhibition of destructive autoimmune arthritis in FcγRIIa transgenic mice by small chemical entities (2009) (40)
Crystal structure of the M5 muscarinic acetylcholine receptor (2019) (39)
The Tyr-Kinase Inhibitor AG879, that Blocks the ETK-PAK1 Interaction, Suppresses the RAS-induced PAK1 Activation and Malignant Transformation (2004) (39)
Inhibitors of Leishmania GDP-Mannose Pyrophosphorylase Identified by High-Throughput Screening of Small-Molecule Chemical Library (2010) (38)
Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity. (2017) (37)
Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL. (2014) (35)
Drug discovery and human African trypanosomiasis: a disease less neglected? (2013) (35)
Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum (2016) (35)
Ask the experts: past, present and future of the rule of five. (2013) (33)
GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity (2017) (33)
Effects of compounds that influence IK (KCNN4) channels on afterhyperpolarizing potentials, and determination of IK channel sequence, in guinea pig enteric neurons. (2007) (33)
Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers (2021) (33)
Screening of the ‘Open Scaffolds’ collection from Compounds Australia identifies a new chemical entity with anthelmintic activities against different developmental stages of the barber's pole worm and other parasitic nematodes☆ (2017) (32)
Assay Interference by Chemical Reactivity (2015) (32)
Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery (2018) (32)
Inhibition studies of sulfonamide-containing folate analogs in yeast. (2003) (31)
Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides. (2016) (31)
Ponatinib (AP24534) inhibits MEKK3-KLF signaling and prevents formation and progression of cerebral cavernous malformations (2018) (30)
Nuisance compounds in cellular assays. (2021) (29)
Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4. (2018) (29)
De-novo designed library of benzoylureas as inhibitors of BCL-XL: synthesis, structural and biochemical characterization. (2014) (28)
Strategies for the Development of Conotoxins as New Therapeutic Leads (2013) (28)
19F NMR as a Probe of Ligand Interactions with the iNOS Binding site of SPRY Domain‐Containing SOCS Box Protein 2 (2014) (27)
3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis. (2013) (27)
Synthesis and biological evaluation of anthranilamide-based non-peptide mimetics of ω-conotoxin GVIA (2006) (27)
Stimulus-cleavable chemistry in the field of controlled drug delivery. (2021) (26)
Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1.3. (2008) (26)
A new class of blockers of the voltage-gated potassium channel Kv1.3 via modification of the 4- or 7-position of khellinone. (2006) (25)
Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors. (2011) (25)
Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus (2017) (23)
Identification of 3-aminothieno[2,3-b]pyridine-2-carboxamides and 4-aminobenzothieno[3,2-d]pyrimidines as LIMK1 inhibitors (2011) (23)
Characterization of the two fundamental conformations of benzoylureas and elucidation of the factors that facilitate their conformational interchange. (2009) (23)
Optimization of Novel 1-Methyl-1 H-Pyrazole-5-carboxamides Leads to High Potency Larval Development Inhibitors of the Barber's Pole Worm. (2018) (22)
Design and synthesis of type-III mimetics of ShK toxin (2002) (21)
Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain (2017) (21)
Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin &agr;/&bgr;1 heterodimer through high‐throughput screening (2018) (21)
8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase. (2018) (20)
Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide (2016) (20)
ω-Conotoxin GVIA Mimetics that Bind and Inhibit Neuronal Cav2.2 Ion Channels (2012) (20)
De novo design and synthesis of a μ-conotoxin KIIIA peptidomimetic. (2013) (19)
Antimalarial 3-arylamino-6-benzylamino-1,2,4,5-tetrazines. (2010) (19)
Redox-active nuisance screening compounds and their classification (2011) (19)
Hypotensive effects of ghrelin receptor agonists mediated through a novel receptor (2014) (18)
A three-residue, continuous binding epitope peptidomimetic of ShK toxin as a Kv1.3 inhibitor. (2005) (18)
Polypeptide ω‐conotoxin GVIA as a basis for new analgesic and neuroprotective agents (1999) (17)
Genome Editing Using Engineered Nucleases and Their Use in Genomic Screening -- Assay Guidance Manual (2004) (17)
Histone acetyltransferase inhibitors: where art thou? (2016) (17)
Regio- and stereoselective iodoacyloxylations of alkynes. (2015) (17)
Synthesis of conformationally constrained benzoylureas as BH3-mimetics. (2012) (17)
Metal-free C-C, C-O, C-S and C-N bond formation enabled by SBA-15 supported TFMSA. (2020) (16)
6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors. (2015) (16)
Redox‐stable cyclic peptide inhibitors of the SPSB2–iNOS interaction (2016) (16)
Design, Synthesis, and Characterization of Cyclic Peptidomimetics of the Inducible Nitric Oxide Synthase Binding Epitope That Disrupt the Protein-Protein Interaction Involving SPRY Domain-Containing Suppressor of Cytokine Signaling Box Protein (SPSB) 2 and Inducible Nitric Oxide Synthase. (2016) (16)
ω-conotoxins and approaches to their non-peptide mimetics (2004) (16)
Omega-conotoxin GVIA mimetics based on an anthranilamide core: effect of variation in ammonium side chain lengths and incorporation of fluorine. (2009) (16)
Benzoylureas as removable cis amide inducers: synthesis of cyclic amides via ring closing metathesis (RCM). (2011) (15)
Tetrahydroquinoxalines induce a lethal evisceration phenotype in Haemonchus contortus in vitro (2018) (15)
Structure-Activity Relationship Studies of Tolfenpyrad Reveal Subnanomolar Inhibitors of Haemonchus contortus Development. (2019) (14)
Discovery of benzoylsulfonohydrazides as potent inhibitors of the histone acetyltransferase KAT6A. (2019) (14)
Facile Synthesis and Preliminary Structure-Activity Analysis of New Sulfonamides Against Trypanosoma brucei. (2014) (13)
Discovery of Potent N-Ethylurea Pyrazole Derivatives as Dual Inhibitors of Trypanosoma brucei and Trypanosoma cruzi. (2019) (13)
Target 2035 – update on the quest for a probe for every protein (2021) (13)
Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli. (2016) (12)
Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus. (2014) (12)
A perspective on the discovery of selected compounds with anthelmintic activity against the barber's pole worm-Where to from here? (2020) (12)
1,2,4-Oxadiazole antimicrobials act synergistically with daptomycin and display rapid kill kinetics against MDR Enterococcus faecium (2018) (11)
Broad activity of diphenyleneiodonium analogues against Mycobacterium tuberculosis, malaria parasites and bacterial pathogens. (2017) (11)
3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity. (2019) (11)
A practical Java tool for small-molecule compound appraisal (2015) (11)
Reviewing Hit Discovery Literature for Difficult Targets: Glutathione Transferase Omega-1 as an Example. (2018) (11)
FLIPR™ Assays for GPCR and Ion Channel Targets -- Assay Guidance Manual (2012) (11)
Substituted Pyridazin-3(2 H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists. (2019) (11)
Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha2beta2gamma1 by the Glucose Importagog SC4 (2018) (11)
A reusable CNTs-supported single-atom iron catalyst for the highly efficient synthesis of C-N bonds. (2020) (10)
New synthetic approaches towards analogues of bedaquiline. (2016) (10)
Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus (2016) (9)
Drug discovery for the treatment of leishmaniasis, African sleeping sickness and Chagas disease. (2013) (9)
Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors. (2020) (9)
Synthesis of 3-(Alkylamino)-, 3-(Alkoxy)-, 3-(Aryloxy)-, 3-(Alkylthio)-, and 3-(Arylthio)-1,2,4-triazines by Using a Unified Route with 3-(Methylsulfonyl)-1,2,4-triazine (2016) (9)
Measurement of β-Arrestin Recruitment for GPCR Targets -- Assay Guidance Manual (2004) (9)
Truncated Latrunculins as Actin Inhibitors Targeting Plasmodium falciparum Motility and Host Cell Invasion. (2016) (9)
Novel 1-Methyl-1 H-pyrazole-5-carboxamide Derivatives with Potent Anthelmintic Activity. (2019) (9)
De Novo Synthesis of a Potent LIMK1 Inhibitor (2010) (9)
Compound-Mediated Assay Interferences in Homogenous Proximity Assays (2004) (8)
A perspective on 10-years HTS experience at the Walter and Eliza Hall Institute of Medical Research - eighteen million assays and counting. (2014) (8)
A novel compound which sensitizes BRAF wild-type melanoma cells to vemurafenib in a TRIM16-dependent manner (2016) (7)
Microwave-assisted, zinc-mediated peptide coupling of N-benzyl-α,α-disubstituted amino acids (2007) (7)
Towards a commercial vaccine against lupinosis. (1998) (7)
Synthesis, reactivity and applications of 1-fluoroalkyl carboxylates: novel synthetic substrates for esterases and lipases (2007) (7)
Synthesis and structure-activity relationship study of pyrrolidine-oxadiazoles as anthelmintics against Haemonchus contortus. (2020) (7)
Development of substituted 7-phenyl-4-aminobenzothieno[3,2-d] pyrimidines as potent LIMK1 inhibitors (2011) (7)
Copper-catalyzed [4 + 2] annulation reaction of β-enaminones and aryl diazonium salts without external oxidant: synthesis of highly functionalized 3H-1,2,4-triazines via homogeneous or heterogeneous strategy (2020) (7)
Synthesis and biological evaluation of nonpeptide mimetics of omega-conotoxin GVIA. (2004) (7)
The promise and peril of chemical probes (vol 11, pg 536, 2015) (2015) (6)
Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines. (2021) (6)
Histone Acetyltransferase Assays in Drug and Chemical Probe Discovery -- Assay Guidance Manual (2018) (6)
Action plan for hit identification (APHID): KAT6A as a case study. (2020) (6)
Catalytic O–H bond insertion reactions using surface modified sewage sludge as a catalyst (2020) (6)
Correspondence: Reply to ‘Compound 17b and formyl peptide receptor biased agonism in relation to cardioprotective effects in ischaemia-reperfusion injury’ (2018) (5)
Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents (2015) (5)
Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi. (2010) (5)
Corrigendum: The promise and peril of chemical probes. (2015) (5)
Turning Waste into Valuable Catalysts: Application of Surface-Modified Sewage Sludge in N–H Insertion Reaction (2020) (4)
Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-XL and BCL-2. (2021) (4)
The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes, and thymic tolerance (2022) (4)
Erratum: The promise and peril of chemical probes (Nature Chemical Biology (2015) 11 (536-541)) (2015) (4)
Ponatinib ( AP 24534 ) inhibits MEKK 3-KLF signaling and prevents formation and progression of cerebral cavernous malformations (2018) (4)
pH-Responsive Polymers for Improving the Signal-to-Noise Ratio of Hypoxia PET Imaging with [18 F]Fluoromisonidazole. (2020) (4)
Porous Silicon Nanocarriers with Stimulus‐Cleavable Linkers for Effective Cancer Therapy (2022) (4)
Automated Electrophysiology Assays -- Assay Guidance Manual (2004) (4)
Design and Assay of Inhibitors of HIV-1 Vpr Cell Killing and Growth Arrest Activity Using Microbial Assay Systems (1998) (3)
Discovery of Acylsulfonohydrazide-Derived Lysine Acetyltransferase (KAT6A) Inhibitors as Potent Senescence-Inducing Anti-Cancer Agents. (2020) (3)
Corrigendum to “Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors” [Bioorg. Med. Chem. Lett. 21 (2011) 5992–5994] (2012) (3)
A new methodology for the synthesis of 3-amino-1H-indole-2-carboxylates (2014) (3)
Erratum: Design and synthesis of type-III mimetics of ω-conotoxin GVIA (Journal of Computer-Aided Molecular Design (2001) vol. 15 (1119-1136)) (2002) (3)
Development of [18F]MIPS15692, a radiotracer with in vitro proof-of-concept for the imaging of MER tyrosine kinase (MERTK) in neuroinflammatory disease. (2021) (3)
Synthesis of 2-phenyl-5,6,7,8-tetrahydroquinoxaline derivatives and screening for P2X1-purinoceptor antagonist activity in isolated preparations of rat vas deferens, for translation into a male contraceptive† (2020) (3)
1,6-Bis(5-acetyl-4,7-dimethoxybenzofuran-6-yloxy)hexane (2004) (3)
Microwave-Assisted, Zinc-Mediated Peptide Coupling of N-Benzyl-α,α-disubstituted Amino Acids. (2007) (2)
Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia (2022) (2)
Hit-to-lead optimization of novel benzimidazole phenylacetamides as broad spectrum trypanosomacides. (2020) (2)
Potassium channel blockers as immunosuppressants (2005) (2)
Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator (2022) (2)
Calcium Channel Blocking Polypeptides (2004) (2)
Personal Accounts of Australian Drug Discovery at the Public–Private Interface (2020) (2)
HBO1 is required for the maintenance of leukaemia stem cells (2019) (1)
I2-Promoted [4 + 2] cycloaddition of in situ generated azoalkenes with enaminones: facile and efficient synthesis of 1,4-dihydropyridazines and pyridazines. (2020) (1)
Synthesis and evaluation of pyridine-derived bedaquiline analogues containing modifications at the A-ring subunit. (2021) (1)
Measurement of cAMP for Gαs- and Gαi Protein-Coupled Receptors (GPCRs) -- Assay Guidance Manual (2004) (1)
Early career research in medicinal chemistry. (2021) (1)
Electrochemical Synthesis of Polysubstituted Sulfonated Pyrazoles via Cascade Intermolecular Condensation, Radical-Radical Cross Coupling Sulfonylation, and Pyrazole Annulation. (2022) (1)
Structure‐Activity Studies of Truncated Latrunculin Analogues with Antimalarial Activity (2020) (1)
Microwave-Assisted Synthesis of α-Diazoesters (2019) (1)
Development of 1,2,4-Oxadiazole Antimicrobial Agents to Treat Enteric Pathogens within the Gastrointestinal Tract (2022) (1)
An alternative approach to the synthesis of peptides containing a cystathionine bridge (2016) (1)
Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus (2017) (1)
Crystal structure of the M5muscarinic acetylcholine receptor. (2019) (1)
Contemporary Anti-Ebola Drug Discovery Approaches and Platforms. (2018) (1)
Hit-to-lead optimization of novel phenyl imidazole carboxamides that are active against Leishmania donovani. (2022) (1)
Discovery of Novel and Potent Benzhydryl‐Tropane Trypanocides Highly Selective for Trypanosoma cruzi. (2010) (0)
New anxiolytic compounds (2007) (0)
Novel Antivirals For Venezuelan Equine Encephalitis (2018) (0)
Table 3: [Examples of notoriously reactive substructures...]. (2015) (0)
Investigation of thiazolyl-benzothiophenamides as potential agents for African sleeping sickness. (2020) (0)
ω-Conotoxins and Approaches to Their Non-Peptide Mimetics. (2004) (0)
Reference compounds for characterizing cellular injury in high-content cellular morphology assays (2022) (0)
Figure 7: [Demonstration of ALARM NMR to...]. (2015) (0)
Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation (2019) (0)
A New Methodology for the Synthesis of 3-Amino-1H-indole-2-carboxylates. (2015) (0)
Meet Our Editorial Board Member (2020) (0)
Development ofBenzenesulfonamide Derivatives as PotentGlutathione Transferase Omega‑1 Inhibitors (2020) (0)
Figure 4: [Assessment of compound activity reversibility...]. (2015) (0)
2020 Reviewer Thanks (2021) (0)
Figure 6: [Assessment of compound stability in...]. (2015) (0)
Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide (2016) (0)
Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors (2017) (0)
Research Overview Polypeptide w-Conotoxin GVIA as a Basis for New Analgesic and Neuroprotective Agents (1999) (0)
Carbene Insertion Reactions for the Construction of C−C and C−Heteroatom Bonds Using Surface Modified Silica Microspheres as Catalysts (2023) (0)
Figure 1: [Typical reactions that are responsible...]. (2015) (0)
Crystal Structure of the MerTK Kinase Domain in Complex with Inhibitor MIPS15692 (2021) (0)
GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity (2017) (0)
Open Source Drug Discovery - Highly Potent Antimalarial Compounds Derived from the GlaxoSmithKline Tres Cantos Arylpyrroles (2013) (0)
Your natural product contains a promiscuous pains motif: Is it useful as a biochemical probe or in drug discovery? (2015) (0)
Correction: Identification of Compounds with Anti-Proliferative Activity against Trypanosoma brucei brucei Strain 427 by a Whole Cell Viability Based HTS Campaign (2013) (0)
Some new leads for Human African Trypanosomiasis (African Sleeping Sickness) (2012) (0)
Table 5: [Examples of nucleophilic probes to...]. (2015) (0)
Crystal structure of MYST acetyltransferase domain in complex with inhibitor 40 (2019) (0)
Methyl (RS)-[1-hydroxy-1-(3-nitrophenyl)-3-oxo-1,3-dihydroisoindol-2-yl]acetate (2003) (0)
Crystal structure of MYST acetyltransferase domain in complex with Acetyl-CoA cofactor (2018) (0)
Novel anti-anxiety drug compounds (2007) (0)
Crystal structure of MYST acetyltransferase domain in complex with inhibitor 83 (2020) (0)
Novel Diarylthioether Compounds as Agents for the Treatment of Chagas Disease. (2023) (0)
MerTK activity is not necessary for the proliferation of glioblastoma stem cells. (2021) (0)
Trypanothione Reductase High-Throughput Screening Campaign Identiﬁes Novel Classes of Inhibitors with Antiparasitic Activity (cid:1) † (2009) (0)
CCDC 1045851: Experimental Crystal Structure Determination (2017) (0)
Crystal structure of MYST acetyltransferase domain in complex with inhibitor 34 (2019) (0)
CCDC 1045852: Experimental Crystal Structure Determination (2017) (0)
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth (2018) (0)
Design, Development, and Optimisation of Smart Linker Chemistry for Targeted Colonic Delivery—In Vitro Evaluation (2023) (0)
Correspondence: Reply to ‘Compound 17b and formyl peptide receptor biased agonism in relation to cardioprotective effects in ischaemia-reperfusion injury’ (2018) (0)
LIM kinase inhibition reduces breast cancer growth and invasiveness but systemic inhibition does not reduce metastasis in mice (2012) (0)
IP issues facing researchers by Gino D'Oca. (2012) (0)
Figure 3: [Assessment of compound inhibition reversibility...]. (2015) (0)
Inhibiteur de proteine kinases et methodes de traitement (2011) (0)
Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus (2016) (0)
Crystal structure of MYST acetyltransferase domain in complex with inhibitor (2018) (0)
New blockers, potassium channel aryl and uses thereof (2008) (0)
Screening of the ‘ Open Scaffolds ’ collection from Compounds Australia identi ﬁ es a new chemical entity with anthelmintic activities against different developmental stages of the barber's pole worm and other parasitic nematodes * Drugs and Drug Resistance (0)
CCDC 1045854: Experimental Crystal Structure Determination (2017) (0)
The Queensland Compound Library - Facilitating biomedical research in the Australasian region (2008) (0)
Table 4: [Examples of databases for examining compound natural histories.]. (2015) (0)
Crystal structure of MYST acetyltransferase domain in complex with inhibitor 39 (2020) (0)
Structure of full-length human AMPK (a2b1g1) in complex with a small molecule activator SC4 (2018) (0)
The Novel bis-1,2,4-Triazine MIPS-0004373 Demonstrates Rapid and Potent Activity against All Blood Stages of the Malaria Parasite (2021) (0)
The future of chemical probes is diversity. (2022) (0)
Figure 5: [Schematic of purification and re-synthesis...]. (2015) (0)
Targeting Control of Cell Cycle Enhances the Activity of Conventional Chemotherapy in Chemotherapy-Resistant Acute Myeloid Leukemia (2021) (0)
Table 2: [Almost all libraries contain potential...]. (2015) (0)
Table 6: [Checklist for de-risking reactive compounds.]. (2015) (0)
1-Methyl-1H-pyrazole-5-carboxamide Derivatives Exhibit Unexpected Acute Mammalian Toxicity. (2020) (0)
Table 1: [Examples of non-selective covalent modifiers...]. (2015) (0)
Figure 2: [Illustrated effect of DTT on...]. (2015) (0)
CCDC 1045853: Experimental Crystal Structure Determination (2017) (0)
Discovery of Anti‐tubercular Analogues of Bedaquiline with Modified A‐, B‐ and C‐Ring Subunits (2022) (0)
Structural Basis for Modulation of a GPCR by Allosteric Drugs (2014) (0)
Research spotlight: The Cooperative Research Centre for Cancer Therapeutics: bridging the gap between leading cancer research at Australia's universities and developing novel cancer drugs. (2010) (0)
Synthesis of 3-(Alkylamino)-, 3-(Alkoxy)-, 3-(Aryloxy)-, 3-(Alkylthio)-, and 3-(Arylthio)-1,2,4-triazines by Using a Unified Route with 3-(Methylsulfonyl)-1,2,4-triazine. (2016) (0)
Crystal structure of MYST acetyltransferase domain in complex with inhibitor CTX-124143 (2019) (0)
Structure of full length human AMPK (a2b2g1) in complex with a small molecule activator SC4. (2018) (0)

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