Jonathan Chernoff
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Engineering Biology
Jonathan Chernoff's Degrees
- Masters Biomedical Engineering Stanford University
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(Suggest an Edit or Addition)Jonathan Chernoff's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1 (*) (1995) (794)
- Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells (1997) (722)
- Rapid Induction of Dendritic Spine Morphogenesis by trans-Synaptic EphrinB-EphB Receptor Activation of the Rho-GEF Kalirin (2003) (507)
- Apoptotic Phosphorylation of Histone H2B Is Mediated by Mammalian Sterile Twenty Kinase (2003) (485)
- Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors. (1995) (423)
- Music and Identity (2012) (413)
- p21-Activated Kinase 1 (Pak1) Regulates Cell Motility in Mammalian Fibroblasts (1999) (407)
- Identification of a Mouse p21Cdc42/Rac Activated Kinase (*) (1995) (400)
- Caspase‐mediated activation and induction of apoptosis by the mammalian Ste20‐like kinase Mst1 (1998) (395)
- p21-activated kinases: three more join the Pak. (2002) (382)
- PAK signalling during the development and progression of cancer (2013) (377)
- An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. (2008) (358)
- A tale of two Paks (2008) (323)
- Heregulin Regulates Cytoskeletal Reorganization and Cell Migration through the p21-activated Kinase-1 via Phosphatidylinositol-3 Kinase* (1998) (313)
- Emerging from the Pak: the p21-activated protein kinase family. (1997) (306)
- Regulation of macropinocytosis by p21-activated kinase-1. (2000) (303)
- Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76. (1998) (300)
- An in vivo assay to test blood vessel permeability. (2013) (297)
- The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1 (1996) (291)
- African Rhythm and African Sensibility: Aesthetics and Social Action in African Musical Idioms (1980) (287)
- Targeting and activation of Rac1 are mediated by the exchange factor β-Pix (2006) (284)
- Regulatable Expression of p21-activated Kinase-1 Promotes Anchorage-independent Growth and Abnormal Organization of Mitotic Spindles in Human Epithelial Breast Cancer Cells* (2000) (281)
- p21-activated Kinase Links Rac/Cdc42 Signaling to Merlin* (2002) (274)
- Direct Binding of the Proline-rich Region of Protein Tyrosine Phosphatase 1B to the Src Homology 3 Domain of p130Cas* (1996) (266)
- The genetics of Pak (2004) (253)
- Protein-Tyrosine Phosphatase 1B Complexes with the Insulin Receptor in Vivo and Is Tyrosine-phosphorylated in the Presence of Insulin* (1997) (247)
- Faculty Opinions recommendation of COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. (2011) (243)
- PTP1B: a double agent in metabolism and oncogenesis. (2010) (225)
- Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts (1997) (218)
- The Ste20-like Protein Kinase, Mst1, Dimerizes and Contains an Inhibitory Domain* (1996) (210)
- Cloning and Characterization of a Human Protein Kinase with Homology to Ste20 (*) (1995) (197)
- Cloning of a cDNA for a major human protein-tyrosine-phosphatase. (1990) (186)
- Regulation of Microfilament Reorganization and Invasiveness of Breast Cancer Cells by Kinase Dead p21-activated Kinase-1* (2000) (185)
- African Rhythm and African Sensibility (1982) (177)
- Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor. (1997) (175)
- p21-Activated Kinase 5 (Pak5) Localizes to Mitochondria and Inhibits Apoptosis by Phosphorylating BAD (2003) (165)
- p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest. (2003) (164)
- Temporal and Spatial Distribution of Activated Pak1 in Fibroblasts (2000) (161)
- Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer. (2016) (158)
- p21‐activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells (2002) (156)
- Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating. (1995) (149)
- Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration (2002) (147)
- Role of Group A p21-activated Kinases in Activation of Extracellular-regulated Kinase by Growth Factors* (2005) (136)
- Protein tyrosine phosphatase 1B negatively regulates integrin signaling (1998) (133)
- Specificity Profiling of Pak Kinases Allows Identification of Novel Phosphorylation Sites* (2007) (132)
- Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. (1995) (128)
- PAK Signaling Drives Acquired Drug Resistance to MAPK Inhibitors in BRAF-mutant Melanomas (2017) (128)
- Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase. (1994) (120)
- Inhibition or Ablation of p21-activated Kinase (PAK1) Disrupts Glucose Homeostatic Mechanisms in Vivo* (2011) (119)
- p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics. (2009) (119)
- Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. (2011) (116)
- Regulation of protein tyrosine phosphatase 1B by sumoylation (2007) (112)
- PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells. (2018) (112)
- p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model. (2012) (107)
- Spatially Distinct Binding of Cdc42 to PAK1 and N-WASP in Breast Carcinoma Cells (2005) (103)
- FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated Schwannomas* (2013) (101)
- A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells (2010) (101)
- Vav1 Transduces T Cell Receptor Signals to the Activation of the Ras/ERK Pathway via LAT, Sos, and RasGRP1* (2004) (101)
- Plant GTPases: the Rhos in bloom. (2000) (99)
- A phosphotyrosyl-protein phosphatase activity associated with acid phosphatase from human prostate gland. (1984) (97)
- Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells. (2009) (94)
- Evidence for a Role of Mixed Lineage Kinases in Neuronal Apoptosis (2001) (93)
- A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. (2006) (90)
- Lentivirus Nef Specifically Activates Pak2 (2000) (87)
- Down-regulation of Insulin Signaling by Protein-tyrosine Phosphatase 1B Is Mediated by an N-terminal Binding Region* (2000) (87)
- Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration (2011) (87)
- A major phosphotyrosyl-protein phosphatase from bovine heart is associated with a low-molecular-weight acid phosphatase. (1985) (86)
- Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes. (2008) (84)
- PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics (2008) (83)
- Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells. (2008) (82)
- Cell Cycle-Regulated Phosphorylation of p21-Activated Kinase 1 (2002) (81)
- AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter. (2003) (80)
- Essential role of CIB1 in regulating PAK1 activation and cell migration (2005) (79)
- Pak1 and PIX regulate contact inhibition during epithelial wound healing (2003) (79)
- Interaction of Rac1 with GTPase-activating Proteins and Putative Effectors (1998) (77)
- Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases (2009) (77)
- Regulation of mammalian Ste20 (Mst) kinases. (2015) (76)
- Targeting Cdc42 in cancer (2013) (75)
- The evolutionary history of effectors downstream of Cdc42 and Rac (2002) (75)
- Transformation Suppression by Protein Tyrosine Phosphatase 1B Requires a Functional SH3 Ligand (1998) (71)
- Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells. (2013) (71)
- Identification of the Atypical MAPK Erk3 as a Novel Substrate for p21-activated Kinase (Pak) Activity* (2011) (71)
- Epitope-tag vectors for eukaryotic protein production. (1995) (69)
- α6β4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-κB-dependent resistance to apoptosis in 3D mammary acini (2007) (67)
- The DeMSTification of Mammalian Ste20 Kinases (2009) (67)
- Protein tyrosine phosphatases as negative regulators of mitogenic signaling (1999) (67)
- Nucleocytoplasmic Shuttling of Pak5 Regulates Its Antiapoptotic Properties (2006) (64)
- NF2: The wizardry of merlin (2003) (64)
- Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A (2010) (60)
- Nerve Growth Factor Stimulates Tyrosine Phosphorylation and Activation of Src Homology-containing Protein-tyrosine Phosphatase 1 in PC12 Cells (*) (1995) (58)
- Rho‐GTPases: New members, new pathways (2005) (57)
- An emerging role for p21-activated kinases (Paks) in viral infections. (2010) (56)
- Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents (2015) (56)
- Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A. (2011) (56)
- Interaction with LC8 Is Required for Pak1 Nuclear Import and Is Indispensable for Zebrafish Development (2009) (55)
- The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis (1992) (54)
- The Tumor Suppressor Mst1 Promotes Changes in the Cellular Redox State by Phosphorylation and Inactivation of Peroxiredoxin-1 Protein* (2013) (54)
- Characterization of a phosphotyrosyl protein phosphatase activity associated with a phosphoseryl protein phosphatase of Mr = 95,000 from bovine heart. (1983) (53)
- A Phosphotyrosine Proteomic Screen Identifies Multiple Tyrosine Kinase Signaling Pathways Aberrantly Activated in Malignant Mesothelioma. (2010) (53)
- Does salmon calcitonin cause cancer? A review and meta-analysis (2015) (51)
- The kinase-inhibitory domain of p21-activated kinase 1 (PAK1) inhibits cell cycle progression independent of PAK1 kinase activity (2007) (51)
- alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini. (2007) (51)
- p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway (2015) (49)
- Mouse models of PAK function (2012) (49)
- Molecular Pathways: Targeting the Kinase Effectors of RHO-Family GTPases (2014) (49)
- Group I p21-Activated Kinases (PAKs) Promote Tumor Cell Proliferation and Survival through the AKT1 and Raf–MAPK Pathways (2012) (49)
- Molecular Pathways: Targeting RAC–p21-Activated Serine–Threonine Kinase Signaling in RAS-Driven Cancers (2014) (48)
- p21-Activated Kinase (PAK) Regulates Cytoskeletal Reorganization and Directional Migration in Human Neutrophils (2013) (48)
- Characterization of Pak2p, a Pleckstrin Homology Domain-containing, p21-activated Protein Kinase from Fission Yeast* (1998) (47)
- Targeting PAK1. (2017) (46)
- The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation. (2013) (45)
- PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome. (2014) (44)
- Suppression of RAC1-driven malignant melanoma by Group A PAK inhibitors (2017) (44)
- PAK kinase regulates Rac GTPase and is a potential target in human schwannomas (2009) (43)
- Detection of peptides, proteins, and drugs that selectively interact with protein targets. (2002) (41)
- Protein-tyrosine Phosphatase 1B Mediates the Effects of Insulin on the Actin Cytoskeleton in Immortalized Fibroblasts* (2003) (40)
- Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization. (2015) (40)
- Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase. (2005) (40)
- P21-activated protein kinase 1 (Pak1) mediates the cross talk between insulin and β-catenin on proglucagon gene expression and its ablation affects glucose homeostasis in male C57BL/6 mice. (2013) (39)
- A fission-yeast gene encoding a protein with features of protein-tyrosine-phosphatases. (1991) (38)
- Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation (2014) (38)
- Characterization of phosphotyrosyl-protein phosphatase activity associated with calcineurin. (1984) (37)
- Group I Paks as therapeutic targets in NF2-deficient meningioma (2015) (36)
- The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment. (2013) (35)
- Delivery of protein into cells using polycationic liposomes. (1995) (35)
- p21 Activated Kinase Signaling Coordinates Glycoprotein Receptor VI–Mediated Platelet Aggregation, Lamellipodia Formation, and Aggregate Stability Under Shear (2013) (35)
- Analysis of Small GTPase Signaling Pathways Using p21-activated Kinase Mutants That Selectively Couple to Cdc42* (2001) (34)
- Pak2 Kinase Restrains Mast Cell FcϵRI Receptor Signaling through Modulation of Rho Protein Guanine Nucleotide Exchange Factor (GEF) Activity* (2012) (34)
- Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells (2005) (34)
- The mTOR pathway affects proliferation and chemosensitivity of urothelial carcinoma cells and is upregulated in a subset of human bladder cancers (2011) (33)
- Multiple forms of phosphotyrosyl- and phosphoseryl-protein phosphatase from cardiac muscle: partial purification and characterization of an EDTA-stimulated phosphotyrosyl-protein phosphatase. (1983) (33)
- Pak2 as a Novel Therapeutic Target for Cardioprotective Endoplasmic Reticulum Stress Response (2019) (33)
- Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer (2019) (32)
- Sequential phosphorylation of SLP‐76 at tyrosine 173 is required for activation of T and mast cells (2011) (31)
- Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains. (2002) (30)
- Protein-tyrosine phosphatase 1B as a potential drug target for obesity. (2003) (30)
- Group I Paks Promote Skeletal Myoblast Differentiation In Vivo and In Vitro (2016) (29)
- Back to the future: Proceedings from the 2010 NF Conference (2011) (27)
- Pak2 Regulates Hematopoietic Progenitor Cell Proliferation, Survival, and Differentiation (2015) (26)
- p21-activated kinases in ErbB2-positive breast cancer (2010) (26)
- The Cross-Rho'ds of Cell-Cell Adhesion* (2004) (25)
- The Rhythmic Medium in African Music (1991) (25)
- p21-activated kinase improves cardiac contractility during ischemia-reperfusion concomitant with changes in troponin-T and myosin light chain 2 phosphorylation. (2012) (25)
- Role of p21-activated kinases in cardiovascular development and function (2013) (25)
- RAC1 as a Therapeutic Target in Malignant Melanoma. (2020) (24)
- p21-activated kinase inhibitors. (2013) (24)
- H-ras Inhibits the Hippo Pathway by Promoting Mst1/Mst2 Heterodimerization (2016) (24)
- Low saliva pH can yield false positives results in simple RT-LAMP-based SARS-CoV-2 diagnostic tests (2021) (23)
- ArhGAP15, a Rac-specific GTPase-activating Protein, Plays a Dual Role in Inhibiting Small GTPase Signaling* (2013) (23)
- Targeting Group I p21-Activated Kinases to Control Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis (2017) (23)
- p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with β-Pix. (2016) (23)
- Group I p21-activated kinases: emerging roles in immune function and viral pathogenesis. (2010) (21)
- Sumoylated protein tyrosine phosphatase 1B localizes to the inner nuclear membrane and regulates the tyrosine phosphorylation of emerin (2012) (21)
- Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP (2016) (21)
- Effects of p21-activated kinase 1 inhibition on 11q13 amplified ovarian cancer cells (2015) (21)
- p21-Activated Kinases Are Required for Transformation in a Cell-Based Model of Neurofibromatosis Type 2 (2010) (21)
- Hustling Is Not Stealing: Stories of an African Bar Girl (2003) (20)
- Inhibition of p21 Activated Kinase (PAK) Reduces Airway Responsiveness In Vivo and In Vitro in Murine and Human Airways (2012) (19)
- FRAX 597 , a Small Molecule Inhibitor of the p 21-activated Kinases , Inhibits Tumorigenesis of Neurofibromatosis Type 2 ( NF 2 )-associated Schwannomas * (2013) (19)
- Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice (2015) (18)
- Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma (2020) (18)
- Intrinsic Resistance to MEK Inhibition through BET Protein–Mediated Kinome Reprogramming in NF1-Deficient Ovarian Cancer (2019) (18)
- The role of p21-activated kinase in the initiation of atherosclerosis (2012) (17)
- Activation of cAMP signaling attenuates impaired hepatic glucose disposal in aged male p21-activated protein kinase-1 knockout mice. (2014) (17)
- Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer (2018) (17)
- PKM2 enters the morpheein academy. (2012) (17)
- Gq-mediated Akt translocation to the membrane: a novel PIP3-independent mechanism in platelets. (2015) (17)
- Temporal and Spatial Distribution of Activated Pak 1 in Fibroblasts (2000) (16)
- Two-hybrid dual bait system to discriminate specificity of protein interactions in small GTPases. (2001) (15)
- Targeting MYC sensitizes malignant mesothelioma cells to PAK blockage-induced cytotoxicity. (2017) (15)
- Close encounters of the LIM-kinase (1999) (14)
- Rho family GTPase Chp/RhoV induces PC12 apoptotic cell death via JNK activation (2011) (14)
- An Essential Role for the Tumor-Suppressor Merlin in Regulating Fatty Acid Synthesis. (2017) (14)
- Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition (2016) (13)
- A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish. (2014) (12)
- Pak GITs to Aurora-A. (2005) (12)
- Rac 1 drives melanoblast organization during mouse development by orchestrating pseudopod-driven motility and cell-cycle progression (2012) (11)
- The Pilgrimage to Mecca: An Excerpt from "A Drummer's Testament" (1984) (11)
- Getting Smart about p21-Activated Kinases (2010) (11)
- The Group I Pak inhibitor Frax-1036 sensitizes 11q13-amplified ovarian cancer cells to the cytotoxic effects of Rottlerin (2017) (10)
- Pak2 regulates myeloid-derived suppressor cell development in mice. (2017) (10)
- Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance (2015) (10)
- Pak1 mediates the stimulatory effect of insulin and curcumin on hepatic ChREBP expression (2017) (10)
- Pak2 Regulation of Nrf2 Serves as a Novel Signaling Nexus Linking ER Stress Response and Oxidative Stress in the Heart (2022) (9)
- Targeting Cdc 42 in cancer (2014) (8)
- Protein tyrosine phosphatase 1 B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor (1997) (8)
- Targeting effector pathways in RAC1P29S-driven malignant melanoma (2019) (8)
- p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways. (2013) (8)
- Author Correction: PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas (2018) (8)
- Role of group A p21-activated kinases in the anti-apoptotic activity of the pseudorabies virus US3 protein kinase. (2011) (8)
- Recent advances in methods to assess the activity of the kinome (2017) (8)
- Production and use of a cell permeable inhibitor of group A Paks (TAT-PID) to analyze signal transduction. (2005) (8)
- Regulation of the catalytic activity of PTP1B: roles for cell adhesion, tyrosine residue 66, and proline residues 309 and 310. (2005) (7)
- BASIC CONGA DRUM RHYTHMS IN AFRICAN-AMERICAN MUSICAL STYLES (1991) (7)
- Medium throughput biochemical compound screening identifies novel agents for pharmacotherapy of neurofibromatosis type 1. (2017) (7)
- Potential Compensation among Group I PAK Members in Hindlimb Ischemia and Wound Healing (2014) (7)
- Identification of a mouse p21cdc42/Rac activated kinase. (1996) (6)
- Music and Historical Consciousness Among the Dagbamba of Ghana (2006) (6)
- The Artistic Challenge of African Music: Thoughts on the Absence of Drum Orchestras in Black American Music (1985) (5)
- PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2). (2021) (5)
- Analysis of PTP1B sumoylation. (2014) (5)
- Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling. (2022) (5)
- Hearing in West African idioms (1997) (5)
- P 21-Activated Protein Kinase 1 ( Pak 1 ) Mediates the Cross Talk between Insulin and-Catenin on Proglucagon Gene Expression and Its Ablation Affects Glucose Homeostasis in Male C 57 BL / 6 Mice (2012) (4)
- Exchange Is Not Robbery: More Stories of an African Bar Girl (2005) (4)
- Hras helps hippo heterodimerize to evade tumor suppression (2018) (3)
- Src transforms in a Cool way (2006) (3)
- Modification of the base excision repair enzyme MBD4 by the small ubiquitin-like molecule SUMO1. (2019) (3)
- p21-Activated Kinase 1 Promotes Breast Tumorigenesis via Phosphorylation and Activation of the Calcium/Calmodulin-Dependent Protein Kinase II (2022) (3)
- PAK1 (p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)) (2011) (3)
- Faculty Opinions recommendation of A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. (2006) (3)
- Author response: Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation (2014) (2)
- Getting Smart about p 21-Activated Kinases (2011) (2)
- Paracrine signal emanating from stressed cardiomyocytes aggravates inflammatory microenvironment in diabetic cardiomyopathy (2022) (2)
- The two-hit theory hits 50 (2021) (2)
- A new concept in NF2 pharmacotherapy: targeting fatty acid synthesis (2018) (2)
- [12] Polymerase chain reaction cloning of related genes (1995) (2)
- High midsummer for small GTPases. (2002) (2)
- Search for Chemical Compounds for Pharmacotherapy of Neurofibromatosis Type 2 (2015) (2)
- Crystal structure of a complex between PTP1B and the insulin receptor tyrosine kinase (2005) (2)
- Regulation of MST complexes and activity via SARAH domain modifications. (2021) (2)
- Polymerase chain reaction cloning of related genes. (1995) (2)
- Nonsteroidal sulfamate derivatives as new therapeutic approaches for Neurofibromatosis 2 (NF2) (2019) (2)
- Loss of Pak1 Corrects Multiple Gain of Function Phenotypes in Nf1+/− Mast Cells. (2007) (1)
- Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases.Cancer Drug Discovery and Development, Volume 5. Edited byJ Silvio Gutkind.Totowa (New Jersey): Humana Press. $165.00. xiv + 578 p; ill.; index. ISBN: 0–89603–710‐X. 2000. (2002) (1)
- A New Rho(d) Map to Diffuse Gastric Cancer. (2020) (1)
- Mitogenic Signal Transduction (2000) (1)
- MYELOID NEOPLASIA PAK 1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome (2015) (1)
- p21-Activated Kinases Regulate Directional Migration and Cytoskeletal Organization in Human Neutrophils (2012) (1)
- Abstract 4865: Pak1 links the Wnt/β-catenin pathway to ErbB2 signaling in breast cancer cells (2012) (1)
- Lentivirus Nef Specifically Activates Pak2 (2000) (1)
- Detection of Heterodimerization of Protein Isoforms Using an in Situ Proximity Ligation Assay. (2018) (1)
- Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation (2022) (1)
- The PAK Signaling System Links Rho Gtpase Activation to Platelet Lamellopodia Formation, Aggregation and Aggregate Stability Under Shear (2012) (1)
- PLATELETS AND THROMBOPOIESIS Pak 2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization (2015) (1)
- Andrews Ofori Danso of Ghana (1977) (1)
- Development and utility of a PAK1-selective degrader (2022) (1)
- Analysis and manipulation of intracellular signaling cascades. (2004) (1)
- Faculty Opinions recommendation of Phosphorylation networks regulating JNK activity in diverse genetic backgrounds. (2008) (1)
- Therapeutics , Targets , and Chemical Biology p 21-Activated Kinase 1 Is Required for Ef fi cient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model (2012) (1)
- HEMATOPOIESIS AND STEM CELLS p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with b -Pix (2016) (1)
- Alfred G. Knudson (1922–2016) (2016) (1)
- P21 activated kinase 1 (PAK1) protects heart from pressure overload induced pathological cardiac remodeling (2009) (1)
- 1 Attenuation of Airway Responsiveness in Pak 1 KO Mice. (2006) (0)
- Abstract A40: Megakaryocyte endomitosis requires Pak2 to regulate actin and microtubule networks. (2015) (0)
- Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1 (cid:1) / (cid:2) mast cells (2008) (0)
- Faculty Opinions recommendation of Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (2005) (0)
- A PTP1B-Cdk3 signaling axis promotes cell cycle progression of human glioblastoma cells through an Rb-E2F dependent pathway (2022) (0)
- Abstract LB-011: PAK1 inhibitor FRAX1036 sensitizes ovarian cancer cells with amplified 11q13 to cytotoxic effect of rottlerin (2016) (0)
- Abstract 1026: Role of Group I Paks in MPNST cell proliferation, migration and invasion (2015) (0)
- Faculty Opinions recommendation of Protein kinase Cζ exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation. (2017) (0)
- Induced Pluripotent Stem Cells as Potential Therapeutic Agents in NF1 (2011) (0)
- The tumor suppressor Merlin regulates fatty acid synthesis thus providing a field for targeted pharmacotherapy of neurofibromatosis type II (2018) (0)
- Peroxiredoxin-1 Protein Phosphorylation and Inactivation of Changes in the Cellular Redox State by The Tumor Suppressor Mst 1 Promotes Signal Transduction : (2013) (0)
- Normal 0 0 Normal 0 0 Normal 0 0 Phenotype 50 100 Phenotype 42 100 Phenotype (2014) (0)
- Author Correction: PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas (2018) (0)
- Faculty Opinions recommendation of High-sensitivity measurements of multiple kinase activities in live single cells. (2014) (0)
- Faculty Opinions recommendation of Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. (2013) (0)
- Faculty Opinions recommendation of Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis. (2007) (0)
- Abstract NTOC-087: DYNAMIC REPROGRAMMING OF THE KINOME OVERCOMES BET PROTEIN INHIBITION IN OVARIAN CANCER (2017) (0)
- Faculty Opinions recommendation of The origins and genetic interactions of KRAS mutations are allele- and tissue-specific. (2021) (0)
- mechanism in platelets -independent 3 -mediated Akt translocation to the membrane: a novel PIP q G (2014) (0)
- Faculty Opinions recommendation of Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination. (2018) (0)
- Abstract 2629: Single and combined inhibition of PAK and Hippo pathway in NF2-deficient schwannoma (2023) (0)
- Abstract LB-001: Functional role of Pak1/Erk signaling in Rac1-related diseases (2016) (0)
- Faculty Opinions recommendation of The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity. (2008) (0)
- Identification of Protein Kinases Required for NF2 Signaling (2007) (0)
- Development of left ventricular cardiac hypertrophy in a p21-activated kinase 1 knockout mouse model is mediated by Erk1 and PP2A. (2011) (0)
- Faculty of 1000 evaluation for Differential effector engagement by oncogenic KRAS. (2018) (0)
- Faculty of 1000 evaluation for Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins. (2018) (0)
- Erk1-Mediated Development of Left Ventricular Cardiac Hypertrophy in a P21 Activated Kinase-1 (Pak1) Knockout Mouse Model (2011) (0)
- SEARCH FOR NEW DRUGS SEARCH FOR CHEMICAL COMPOUNDS FOR PHARMACOTHERAPY OF NEUROFIBROMATOSIS TYPE 2 (2015) (0)
- In Memoriam: Beatrice Mintz, PhD (1921–2022) (2022) (0)
- Faculty Opinions recommendation of Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms. (2008) (0)
- Pak2 Regulates MDSC Development and Function (2016) (0)
- STK4 (serine/threonine kinase 4) (2011) (0)
- Results Expression of RAC 1 P 29 S modifies zebrafish embryonic development and activates ERK through Group A PAKs (2018) (0)
- Abstract 242: p21-Activated Kinase Regulates Vascular Smooth Muscle Migration Leading to Arterial Stenosis (2008) (0)
- Pak A proteins are essential for hematopoietic stem/progenitor cell (HSC/P) engraftment through regulation of signaling pathways controlling HSC/P proliferation, survival, migration, and the actin cytoskeleton (2011) (0)
- Faculty Opinions recommendation of A Universal Surrogate Reporter for Efficient Enrichment of CRISPR/Cas9-Mediated Homology-Directed Repair in Mammalian Cells. (2020) (0)
- 2020 in 20/20 hindsight (2021) (0)
- Faculty Opinions recommendation of Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer. (2017) (0)
- Faculty Opinions recommendation of Small-molecule hydrophobic tagging-induced degradation of HaloTag fusion proteins. (2011) (0)
- 2 Signal Transduction andMammalian Cell Growth : Problems and Paradigms (2005) (0)
- Abstract B31: Pak1 and β-catenin inhibition blocks tumor progression in ErbB2-driven breast cancer models (2013) (0)
- Abstract 2587: RAC1P29Sexpression in melanocytes is associated with increased DNA damage and altered cell cycle progression (2020) (0)
- RAS family mutation patterns in a large cohort of CRCs. (2016) (0)
- Paks integrate polarity and vesicle transport signaling in ovarian epithelial cancers (2016) (0)
- Faculty Opinions recommendation of Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. (2021) (0)
- Faculty Opinions recommendation of Precise manipulation of chromosomes in vivo enables genome-wide codon replacement. (2011) (0)
- Cancer Discovery “In the Spotlight” A new Rho’d-map to diffuse gastric cancer (2020) (0)
- Abstract 1086: Downstream kinase signaling is dictated by specific KRAS mutations (2020) (0)
- Faculty Opinions recommendation of A pan-cancer proteomic perspective on The Cancer Genome Atlas. (2017) (0)
- Abstract 1876: Reduced Pak1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition (2016) (0)
- Faculty Opinions recommendation of Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase. (2007) (0)
- Analysis of p21-Activated Kinase Function in Neurofibromatosis Type 2 (2007) (0)
- Faculty Opinions recommendation of Identification of MRTX1133, a noncovalent, potent, and selective KRASG12D inhibitor. (2021) (0)
- Abstract 1242: Combination of p21-activated kinase 1 (PAK1) inhibitor FRAX1036 and Aurora-A inhibitor alisertib is effective in hormone receptor-positive breast cancer (2016) (0)
- Faculty Opinions recommendation of Enhancement of learning and memory after activation of cerebral Rho GTPases. (2007) (0)
- Faculty Opinions recommendation of Inhibition of Lapatinib-Induced Kinome Reprogramming in ERBB2-Positive Breast Cancer by Targeting BET Family Bromodomains. (2017) (0)
- How much is my paper worth? (2019) (0)
- Faculty Opinions recommendation of Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. (2019) (0)
- Decision letter: Extraction of active RhoGTPases by RhoGDI regulates spatiotemporal patterning of RhoGTPases (2019) (0)
- Alfred G. Knudson Jr, MD, PhD: In Memoriam (1922-2016). (2017) (0)
- Abstract B066: Unique roles of group I PAK isoforms in regulating MPNST cell viability (2018) (0)
- Faculty Opinions recommendation of PAK4 inhibition improves PD-1 blockade immunotherapy. (2020) (0)
- Faculty Opinions recommendation of Multiplexed in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity. (2018) (0)
- Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer (2018) (0)
- Faculty Opinions recommendation of PAK2 Haploinsufficiency Results in Synaptic Cytoskeleton Impairment and Autism-Related Behavior. (2018) (0)
- 775 THE MTOR PATHWAY IMPACTS PROLIFERATION AND CHEMOSENSITIVITY OF UROTHELIAL CARCINOMA CELLS IN VITRO AND IS HIGHLY EXPRESSED IN A SUBSET OF HUMAN BLADDER CANCERS (2010) (0)
- Playing signaling chess with the KRAS oncogene (2017) (0)
- TheFission YeastGenespypl+andpyp2+EncodeProtein Tyrosine Phosphatases ThatNegatively Regulate Mitosis (1992) (0)
- Faculty Opinions recommendation of Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1P29S Melanoma Cells. (2019) (0)
- Abstract 8840: P21-Activated Kinase Improves Myocardial Performance through Modulation of Troponin-T and Myosin Light Chain 2 during Global Myocardial Ischemia and Reperfusion Injury (2011) (0)
- COMMENTARY Getting Smart about p21-Activated Kinases (2011) (0)
- Targeting P21-Activated Kinase-1 for Metastatic Prostate Cancer (2023) (0)
- Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Malignant Mesothelioma (2020) (0)
- Kinase Activity Of Pak2, An Effector Of Rac/CDC42 and Its Interaction With β-PIX Is Required For Murine Hematopoietic Stem Cell Shape, F-Actin Formation, Directional Migration In Vitro and For HSPC Homing To Bone Marrow In Vivo (2013) (0)
- Faculty Opinions recommendation of Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities. (2016) (0)
- Group A Pak Proteins Are Essential for HSC/P Engraftment. (2010) (0)
- 1 Therapeutics, Targets, and Chemical Biology (2012) (0)
- Faculty Opinions recommendation of Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer. (2020) (0)
- Faculty Opinions recommendation of Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma. (2021) (0)
- Role of p21-activated kinases in cardiovascular development and function (2013) (0)
- Abstract A15: Megakaryocyte differentiation is regulated by p21-activated kinase 2 (2014) (0)
- How to get and keep your lab funded (2018) (0)
- Faculty Opinions recommendation of Pak1 control of E-cadherin endocytosis regulates salivary gland lumen size and shape. (2010) (0)
- Faculty Opinions recommendation of Critical roles of phosphoinositides and NF2 in Hippo pathway regulation. (2021) (0)
- Testing the Role of p21-Activated Kinases in Schwannoma Formation Using a Novel Genetically Engineered Murine Model that Closely Phenocopies Human NF2 Disease (2015) (0)
- Faculty Opinions recommendation of Rapid diversification of cell signaling phenotypes by modular domain recombination. (2010) (0)
- Faculty Opinions recommendation of A new family of RhoGEFs activates the Rop molecular switch in plants. (2005) (0)
- Search for Chemical Compounds for Pharmacotherapy of Neurofibromatosis Type 2 (2015) (0)
- Faculty Opinions recommendation of PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. (2005) (0)
- Faculty Opinions recommendation of Quantifying the evolutionary dynamics of language. (2007) (0)
- Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents (2015) (0)
- COMMENTARY Getting Smart about p21-Activated Kinases (cid:1) (2011) (0)
- A Facile Method to Engineer Mutant Kras Alleles in an Isogenic Cell Background. (2021) (0)
- LOV conquers (sm)All GTPases (2010) (0)
- Faculty Opinions recommendation of Identification of an oncogenic RAB protein. (2015) (0)
- Gary M. Bokoch (1954–2010) (2010) (0)
- Faculty Opinions recommendation of A kinome-wide screen using a NanoLuc LATS luminescent biosensor identifies ALK as a novel regulator of the Hippo pathway in tumorigenesis and immune evasion. (2019) (0)
- Abstract A34: Defining KRAS mutation-specific kinome signatures and vulnerabilities in colorectal cancer (2020) (0)
- Decision letter: Signaling levels mold the RAS mutation tropism of urethane (2021) (0)
- Faculty Opinions recommendation of mTORC2 regulates cardiac response to stress by inhibiting MST1. (2015) (0)
- Faculty of 1000 evaluation for Challenges in validating candidate therapeutic targets in cancer. (2018) (0)
- Abstract A02: Pak1 kinase inhibition sensitizes 11q13 amplified breast cancer cells to platinum based chemotherapy via downregulation of Fanconi anemia genes (2014) (0)
- Nonsteroidal sulfamate derivatives as new therapeutic approaches for Neurofibromatosis 2 (NF2) (2019) (0)
- Faculty Opinions recommendation of Quantitative morphological signatures define local signaling networks regulating cell morphology. (2007) (0)
- Faculty Opinions recommendation of Interconversion between intestinal stem cell populations in distinct niches. (2011) (0)
- Faculty Opinions recommendation of RAC1P29S induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance. (2019) (0)
- Mammalian sterile20-like kinase 1 (Mst1) exerts its tumor suppressor function through its downstream effector peroxiredoxin 1 (2014) (0)
- Role of p21-activated kinases 1 and 2 in pseudorabies virus US3-mediated effects on apoptosis and nuclear egress (2010) (0)
- Faculty Opinions recommendation of Inhibitor hijacking of Akt activation. (2009) (0)
- Faculty Opinions recommendation of Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells. (2018) (0)
- General/Theoretical Anthropology: Lives in Between: Assimilation and Marginality in Austria, Brazil, and West Africa, 1780–1945. Leo Spitzer. (1991) (0)
- P-21 Activated Kinase 1 (Pak1) Is Critical for Normal Mast Cell Degranulation and Cytokine Production in Response to Antigen Stimulation of the High Affinity IgE Receptor. (2004) (0)
- Ethnographic Highs: The Forest People & African Rhythm and African Sensibility (2017) (0)
- Coming to Terms with Witchcraft (1990) (0)
- Music of the Dagomba of Ghana (1984) (0)
- African Rhythm: A Northern Ewe Perspective. Kofi Agawu (1997) (0)
- Cote d'Ivoire: Music of the We (Guere)@@@Senegal: Le Saoruba de Casamance@@@Master Fiddlers of Dagbon@@@Nigeria: Griots Hausa@@@Mbum du Cameroun: Nord Cameroun (2003) (0)
- Social/Cultural Anthropology: In Sorcery's Shadow: A Memoir of Apprenticeship Among the Songhay of Niger. Paul Stoller and Cheryl Olkes. (1988) (0)
- A Day for the Hunter, a Day for the Prey: Popular Music and Power in Haiti (review) (2001) (0)
- Life Within Limits: well-being in a world of want (review) (2012) (0)
- Linguistic Anthropology: Dried Millet Breaking: Time, Words, and Song in the Woi Epic of the Kpelle. Ruth M. Stone (1989) (0)
- REVIEW: Gage Averill.A DAY FOR THE HUNTER, A DAY FOR THE PREY: POPULAR MUSIC AND POWER IN HAITI, Chicago: U of Chicago P, 1997. (2001) (0)
- Culture and the senses: bodily ways of knowing in an African community – By Kathryn Linn Geurts (2008) (0)
- THREE KILOS OF COFFEE: AN AUTOBIOGRAPHY, by Manu Dibango, in collaboration with Danielle Rouard, translated by Beth G. Raps, Univ. of Chicago Press, Chicago and London, 1994, 146pp, index, discography, photographs. (1996) (0)
- Midwest Society for Pediatric Research Abstracts and Index (2007) (0)
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What Schools Are Affiliated With Jonathan Chernoff?
Jonathan Chernoff is affiliated with the following schools: