Jonathan Chernoff

Jonathan Chernoff's AcademicInfluence.com Rankings

Jonathan Chernoff

Engineering

#4387

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#5580

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Biomedical Engineering

#273

World Rank

#280

Historical Rank

Applied Physics

#1056

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#1082

Historical Rank

engineering Degrees

Jonathan Chernoff

Biology

#8448

World Rank

#11524

Historical Rank

Molecular Biology

#1077

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#1102

Historical Rank

biology Degrees

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Engineering
Biology

Jonathan Chernoff's Degrees

Masters Biomedical Engineering Stanford University

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Jonathan Chernoff's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1 (*) (1995) (794)
Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells (1997) (722)
Rapid Induction of Dendritic Spine Morphogenesis by trans-Synaptic EphrinB-EphB Receptor Activation of the Rho-GEF Kalirin (2003) (507)
Apoptotic Phosphorylation of Histone H2B Is Mediated by Mammalian Sterile Twenty Kinase (2003) (485)
Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors. (1995) (423)
Music and Identity (2012) (413)
p21-Activated Kinase 1 (Pak1) Regulates Cell Motility in Mammalian Fibroblasts (1999) (407)
Identification of a Mouse p21Cdc42/Rac Activated Kinase (*) (1995) (400)
Caspase‐mediated activation and induction of apoptosis by the mammalian Ste20‐like kinase Mst1 (1998) (395)
p21-activated kinases: three more join the Pak. (2002) (382)
PAK signalling during the development and progression of cancer (2013) (377)
An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. (2008) (358)
A tale of two Paks (2008) (323)
Heregulin Regulates Cytoskeletal Reorganization and Cell Migration through the p21-activated Kinase-1 via Phosphatidylinositol-3 Kinase* (1998) (313)
Emerging from the Pak: the p21-activated protein kinase family. (1997) (306)
Regulation of macropinocytosis by p21-activated kinase-1. (2000) (303)
Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76. (1998) (300)
An in vivo assay to test blood vessel permeability. (2013) (297)
The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1 (1996) (291)
African Rhythm and African Sensibility: Aesthetics and Social Action in African Musical Idioms (1980) (287)
Targeting and activation of Rac1 are mediated by the exchange factor β-Pix (2006) (284)
Regulatable Expression of p21-activated Kinase-1 Promotes Anchorage-independent Growth and Abnormal Organization of Mitotic Spindles in Human Epithelial Breast Cancer Cells* (2000) (281)
p21-activated Kinase Links Rac/Cdc42 Signaling to Merlin* (2002) (274)
Direct Binding of the Proline-rich Region of Protein Tyrosine Phosphatase 1B to the Src Homology 3 Domain of p130Cas* (1996) (266)
The genetics of Pak (2004) (253)
Protein-Tyrosine Phosphatase 1B Complexes with the Insulin Receptor in Vivo and Is Tyrosine-phosphorylated in the Presence of Insulin* (1997) (247)
Faculty Opinions recommendation of COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. (2011) (243)
PTP1B: a double agent in metabolism and oncogenesis. (2010) (225)
Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts (1997) (218)
The Ste20-like Protein Kinase, Mst1, Dimerizes and Contains an Inhibitory Domain* (1996) (210)
Cloning and Characterization of a Human Protein Kinase with Homology to Ste20 (*) (1995) (197)
Cloning of a cDNA for a major human protein-tyrosine-phosphatase. (1990) (186)
Regulation of Microfilament Reorganization and Invasiveness of Breast Cancer Cells by Kinase Dead p21-activated Kinase-1* (2000) (185)
African Rhythm and African Sensibility (1982) (177)
Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor. (1997) (175)
p21-Activated Kinase 5 (Pak5) Localizes to Mitochondria and Inhibits Apoptosis by Phosphorylating BAD (2003) (165)
p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest. (2003) (164)
Temporal and Spatial Distribution of Activated Pak1 in Fibroblasts (2000) (161)
Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer. (2016) (158)
p21‐activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells (2002) (156)
Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating. (1995) (149)
Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration (2002) (147)
Role of Group A p21-activated Kinases in Activation of Extracellular-regulated Kinase by Growth Factors* (2005) (136)
Protein tyrosine phosphatase 1B negatively regulates integrin signaling (1998) (133)
Specificity Profiling of Pak Kinases Allows Identification of Novel Phosphorylation Sites* (2007) (132)
Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. (1995) (128)
PAK Signaling Drives Acquired Drug Resistance to MAPK Inhibitors in BRAF-mutant Melanomas (2017) (128)
Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase. (1994) (120)
Inhibition or Ablation of p21-activated Kinase (PAK1) Disrupts Glucose Homeostatic Mechanisms in Vivo* (2011) (119)
p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics. (2009) (119)
Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. (2011) (116)
Regulation of protein tyrosine phosphatase 1B by sumoylation (2007) (112)
PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells. (2018) (112)
p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model. (2012) (107)
Spatially Distinct Binding of Cdc42 to PAK1 and N-WASP in Breast Carcinoma Cells (2005) (103)
FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated Schwannomas* (2013) (101)
A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells (2010) (101)
Vav1 Transduces T Cell Receptor Signals to the Activation of the Ras/ERK Pathway via LAT, Sos, and RasGRP1* (2004) (101)
Plant GTPases: the Rhos in bloom. (2000) (99)
A phosphotyrosyl-protein phosphatase activity associated with acid phosphatase from human prostate gland. (1984) (97)
Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells. (2009) (94)
Evidence for a Role of Mixed Lineage Kinases in Neuronal Apoptosis (2001) (93)
A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. (2006) (90)
Lentivirus Nef Specifically Activates Pak2 (2000) (87)
Down-regulation of Insulin Signaling by Protein-tyrosine Phosphatase 1B Is Mediated by an N-terminal Binding Region* (2000) (87)
Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration (2011) (87)
A major phosphotyrosyl-protein phosphatase from bovine heart is associated with a low-molecular-weight acid phosphatase. (1985) (86)
Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes. (2008) (84)
PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics (2008) (83)
Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells. (2008) (82)
Cell Cycle-Regulated Phosphorylation of p21-Activated Kinase 1 (2002) (81)
AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter. (2003) (80)
Essential role of CIB1 in regulating PAK1 activation and cell migration (2005) (79)
Pak1 and PIX regulate contact inhibition during epithelial wound healing (2003) (79)
Interaction of Rac1 with GTPase-activating Proteins and Putative Effectors (1998) (77)
Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases (2009) (77)
Regulation of mammalian Ste20 (Mst) kinases. (2015) (76)
Targeting Cdc42 in cancer (2013) (75)
The evolutionary history of effectors downstream of Cdc42 and Rac (2002) (75)
Transformation Suppression by Protein Tyrosine Phosphatase 1B Requires a Functional SH3 Ligand (1998) (71)
Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells. (2013) (71)
Identification of the Atypical MAPK Erk3 as a Novel Substrate for p21-activated Kinase (Pak) Activity* (2011) (71)
Epitope-tag vectors for eukaryotic protein production. (1995) (69)
α6β4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-κB-dependent resistance to apoptosis in 3D mammary acini (2007) (67)
The DeMSTification of Mammalian Ste20 Kinases (2009) (67)
Protein tyrosine phosphatases as negative regulators of mitogenic signaling (1999) (67)
Nucleocytoplasmic Shuttling of Pak5 Regulates Its Antiapoptotic Properties (2006) (64)
NF2: The wizardry of merlin (2003) (64)
Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A (2010) (60)
Nerve Growth Factor Stimulates Tyrosine Phosphorylation and Activation of Src Homology-containing Protein-tyrosine Phosphatase 1 in PC12 Cells (*) (1995) (58)
Rho‐GTPases: New members, new pathways (2005) (57)
An emerging role for p21-activated kinases (Paks) in viral infections. (2010) (56)
Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents (2015) (56)
Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A. (2011) (56)
Interaction with LC8 Is Required for Pak1 Nuclear Import and Is Indispensable for Zebrafish Development (2009) (55)
The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis (1992) (54)
The Tumor Suppressor Mst1 Promotes Changes in the Cellular Redox State by Phosphorylation and Inactivation of Peroxiredoxin-1 Protein* (2013) (54)
Characterization of a phosphotyrosyl protein phosphatase activity associated with a phosphoseryl protein phosphatase of Mr = 95,000 from bovine heart. (1983) (53)
A Phosphotyrosine Proteomic Screen Identifies Multiple Tyrosine Kinase Signaling Pathways Aberrantly Activated in Malignant Mesothelioma. (2010) (53)
Does salmon calcitonin cause cancer? A review and meta-analysis (2015) (51)
The kinase-inhibitory domain of p21-activated kinase 1 (PAK1) inhibits cell cycle progression independent of PAK1 kinase activity (2007) (51)
alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini. (2007) (51)
p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway (2015) (49)
Mouse models of PAK function (2012) (49)
Molecular Pathways: Targeting the Kinase Effectors of RHO-Family GTPases (2014) (49)
Group I p21-Activated Kinases (PAKs) Promote Tumor Cell Proliferation and Survival through the AKT1 and Raf–MAPK Pathways (2012) (49)
Molecular Pathways: Targeting RAC–p21-Activated Serine–Threonine Kinase Signaling in RAS-Driven Cancers (2014) (48)
p21-Activated Kinase (PAK) Regulates Cytoskeletal Reorganization and Directional Migration in Human Neutrophils (2013) (48)
Characterization of Pak2p, a Pleckstrin Homology Domain-containing, p21-activated Protein Kinase from Fission Yeast* (1998) (47)
Targeting PAK1. (2017) (46)
The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation. (2013) (45)
PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome. (2014) (44)
Suppression of RAC1-driven malignant melanoma by Group A PAK inhibitors (2017) (44)
PAK kinase regulates Rac GTPase and is a potential target in human schwannomas (2009) (43)
Detection of peptides, proteins, and drugs that selectively interact with protein targets. (2002) (41)
Protein-tyrosine Phosphatase 1B Mediates the Effects of Insulin on the Actin Cytoskeleton in Immortalized Fibroblasts* (2003) (40)
Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization. (2015) (40)
Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase. (2005) (40)
P21-activated protein kinase 1 (Pak1) mediates the cross talk between insulin and β-catenin on proglucagon gene expression and its ablation affects glucose homeostasis in male C57BL/6 mice. (2013) (39)
A fission-yeast gene encoding a protein with features of protein-tyrosine-phosphatases. (1991) (38)
Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation (2014) (38)
Characterization of phosphotyrosyl-protein phosphatase activity associated with calcineurin. (1984) (37)
Group I Paks as therapeutic targets in NF2-deficient meningioma (2015) (36)
The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment. (2013) (35)
Delivery of protein into cells using polycationic liposomes. (1995) (35)
p21 Activated Kinase Signaling Coordinates Glycoprotein Receptor VI–Mediated Platelet Aggregation, Lamellipodia Formation, and Aggregate Stability Under Shear (2013) (35)
Analysis of Small GTPase Signaling Pathways Using p21-activated Kinase Mutants That Selectively Couple to Cdc42* (2001) (34)
Pak2 Kinase Restrains Mast Cell FcϵRI Receptor Signaling through Modulation of Rho Protein Guanine Nucleotide Exchange Factor (GEF) Activity* (2012) (34)
Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells (2005) (34)
The mTOR pathway affects proliferation and chemosensitivity of urothelial carcinoma cells and is upregulated in a subset of human bladder cancers (2011) (33)
Multiple forms of phosphotyrosyl- and phosphoseryl-protein phosphatase from cardiac muscle: partial purification and characterization of an EDTA-stimulated phosphotyrosyl-protein phosphatase. (1983) (33)
Pak2 as a Novel Therapeutic Target for Cardioprotective Endoplasmic Reticulum Stress Response (2019) (33)
Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer (2019) (32)
Sequential phosphorylation of SLP‐76 at tyrosine 173 is required for activation of T and mast cells (2011) (31)
Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains. (2002) (30)
Protein-tyrosine phosphatase 1B as a potential drug target for obesity. (2003) (30)
Group I Paks Promote Skeletal Myoblast Differentiation In Vivo and In Vitro (2016) (29)
Back to the future: Proceedings from the 2010 NF Conference (2011) (27)
Pak2 Regulates Hematopoietic Progenitor Cell Proliferation, Survival, and Differentiation (2015) (26)
p21-activated kinases in ErbB2-positive breast cancer (2010) (26)
The Cross-Rho'ds of Cell-Cell Adhesion* (2004) (25)
The Rhythmic Medium in African Music (1991) (25)
p21-activated kinase improves cardiac contractility during ischemia-reperfusion concomitant with changes in troponin-T and myosin light chain 2 phosphorylation. (2012) (25)
Role of p21-activated kinases in cardiovascular development and function (2013) (25)
RAC1 as a Therapeutic Target in Malignant Melanoma. (2020) (24)
p21-activated kinase inhibitors. (2013) (24)
H-ras Inhibits the Hippo Pathway by Promoting Mst1/Mst2 Heterodimerization (2016) (24)
Low saliva pH can yield false positives results in simple RT-LAMP-based SARS-CoV-2 diagnostic tests (2021) (23)
ArhGAP15, a Rac-specific GTPase-activating Protein, Plays a Dual Role in Inhibiting Small GTPase Signaling* (2013) (23)
Targeting Group I p21-Activated Kinases to Control Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis (2017) (23)
p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with β-Pix. (2016) (23)
Group I p21-activated kinases: emerging roles in immune function and viral pathogenesis. (2010) (21)
Sumoylated protein tyrosine phosphatase 1B localizes to the inner nuclear membrane and regulates the tyrosine phosphorylation of emerin (2012) (21)
Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP (2016) (21)
Effects of p21-activated kinase 1 inhibition on 11q13 amplified ovarian cancer cells (2015) (21)
p21-Activated Kinases Are Required for Transformation in a Cell-Based Model of Neurofibromatosis Type 2 (2010) (21)
Hustling Is Not Stealing: Stories of an African Bar Girl (2003) (20)
Inhibition of p21 Activated Kinase (PAK) Reduces Airway Responsiveness In Vivo and In Vitro in Murine and Human Airways (2012) (19)
FRAX 597 , a Small Molecule Inhibitor of the p 21-activated Kinases , Inhibits Tumorigenesis of Neurofibromatosis Type 2 ( NF 2 )-associated Schwannomas * (2013) (19)
Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice (2015) (18)
Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma (2020) (18)
Intrinsic Resistance to MEK Inhibition through BET Protein–Mediated Kinome Reprogramming in NF1-Deficient Ovarian Cancer (2019) (18)
The role of p21-activated kinase in the initiation of atherosclerosis (2012) (17)
Activation of cAMP signaling attenuates impaired hepatic glucose disposal in aged male p21-activated protein kinase-1 knockout mice. (2014) (17)
Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer (2018) (17)
PKM2 enters the morpheein academy. (2012) (17)
Gq-mediated Akt translocation to the membrane: a novel PIP3-independent mechanism in platelets. (2015) (17)
Temporal and Spatial Distribution of Activated Pak 1 in Fibroblasts (2000) (16)
Two-hybrid dual bait system to discriminate specificity of protein interactions in small GTPases. (2001) (15)
Targeting MYC sensitizes malignant mesothelioma cells to PAK blockage-induced cytotoxicity. (2017) (15)
Close encounters of the LIM-kinase (1999) (14)
Rho family GTPase Chp/RhoV induces PC12 apoptotic cell death via JNK activation (2011) (14)
An Essential Role for the Tumor-Suppressor Merlin in Regulating Fatty Acid Synthesis. (2017) (14)
Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition (2016) (13)
A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish. (2014) (12)
Pak GITs to Aurora-A. (2005) (12)
Rac 1 drives melanoblast organization during mouse development by orchestrating pseudopod-driven motility and cell-cycle progression (2012) (11)
The Pilgrimage to Mecca: An Excerpt from "A Drummer's Testament" (1984) (11)
Getting Smart about p21-Activated Kinases (2010) (11)
The Group I Pak inhibitor Frax-1036 sensitizes 11q13-amplified ovarian cancer cells to the cytotoxic effects of Rottlerin (2017) (10)
Pak2 regulates myeloid-derived suppressor cell development in mice. (2017) (10)
Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance (2015) (10)
Pak1 mediates the stimulatory effect of insulin and curcumin on hepatic ChREBP expression (2017) (10)
Pak2 Regulation of Nrf2 Serves as a Novel Signaling Nexus Linking ER Stress Response and Oxidative Stress in the Heart (2022) (9)
Targeting Cdc 42 in cancer (2014) (8)
Protein tyrosine phosphatase 1 B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor (1997) (8)
Targeting effector pathways in RAC1P29S-driven malignant melanoma (2019) (8)
p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways. (2013) (8)
Author Correction: PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas (2018) (8)
Role of group A p21-activated kinases in the anti-apoptotic activity of the pseudorabies virus US3 protein kinase. (2011) (8)
Recent advances in methods to assess the activity of the kinome (2017) (8)
Production and use of a cell permeable inhibitor of group A Paks (TAT-PID) to analyze signal transduction. (2005) (8)
Regulation of the catalytic activity of PTP1B: roles for cell adhesion, tyrosine residue 66, and proline residues 309 and 310. (2005) (7)
BASIC CONGA DRUM RHYTHMS IN AFRICAN-AMERICAN MUSICAL STYLES (1991) (7)
Medium throughput biochemical compound screening identifies novel agents for pharmacotherapy of neurofibromatosis type 1. (2017) (7)
Potential Compensation among Group I PAK Members in Hindlimb Ischemia and Wound Healing (2014) (7)
Identification of a mouse p21cdc42/Rac activated kinase. (1996) (6)
Music and Historical Consciousness Among the Dagbamba of Ghana (2006) (6)
The Artistic Challenge of African Music: Thoughts on the Absence of Drum Orchestras in Black American Music (1985) (5)
PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2). (2021) (5)
Analysis of PTP1B sumoylation. (2014) (5)
Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling. (2022) (5)
Hearing in West African idioms (1997) (5)
P 21-Activated Protein Kinase 1 ( Pak 1 ) Mediates the Cross Talk between Insulin and-Catenin on Proglucagon Gene Expression and Its Ablation Affects Glucose Homeostasis in Male C 57 BL / 6 Mice (2012) (4)
Exchange Is Not Robbery: More Stories of an African Bar Girl (2005) (4)
Hras helps hippo heterodimerize to evade tumor suppression (2018) (3)
Src transforms in a Cool way (2006) (3)
Modification of the base excision repair enzyme MBD4 by the small ubiquitin-like molecule SUMO1. (2019) (3)
p21-Activated Kinase 1 Promotes Breast Tumorigenesis via Phosphorylation and Activation of the Calcium/Calmodulin-Dependent Protein Kinase II (2022) (3)
PAK1 (p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)) (2011) (3)
Faculty Opinions recommendation of A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. (2006) (3)
Author response: Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation (2014) (2)
Getting Smart about p 21-Activated Kinases (2011) (2)
Paracrine signal emanating from stressed cardiomyocytes aggravates inflammatory microenvironment in diabetic cardiomyopathy (2022) (2)
The two-hit theory hits 50 (2021) (2)
A new concept in NF2 pharmacotherapy: targeting fatty acid synthesis (2018) (2)
[12] Polymerase chain reaction cloning of related genes (1995) (2)
High midsummer for small GTPases. (2002) (2)
Search for Chemical Compounds for Pharmacotherapy of Neurofibromatosis Type 2 (2015) (2)
Crystal structure of a complex between PTP1B and the insulin receptor tyrosine kinase (2005) (2)
Regulation of MST complexes and activity via SARAH domain modifications. (2021) (2)
Polymerase chain reaction cloning of related genes. (1995) (2)
Nonsteroidal sulfamate derivatives as new therapeutic approaches for Neurofibromatosis 2 (NF2) (2019) (2)
Loss of Pak1 Corrects Multiple Gain of Function Phenotypes in Nf1+/− Mast Cells. (2007) (1)
Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases.Cancer Drug Discovery and Development, Volume 5. Edited byJ Silvio Gutkind.Totowa (New Jersey): Humana Press. $165.00. xiv + 578 p; ill.; index. ISBN: 0–89603–710‐X. 2000. (2002) (1)
A New Rho(d) Map to Diffuse Gastric Cancer. (2020) (1)
Mitogenic Signal Transduction (2000) (1)
MYELOID NEOPLASIA PAK 1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome (2015) (1)
p21-Activated Kinases Regulate Directional Migration and Cytoskeletal Organization in Human Neutrophils (2012) (1)
Abstract 4865: Pak1 links the Wnt/β-catenin pathway to ErbB2 signaling in breast cancer cells (2012) (1)
Lentivirus Nef Speciﬁcally Activates Pak2 (2000) (1)
Detection of Heterodimerization of Protein Isoforms Using an in Situ Proximity Ligation Assay. (2018) (1)
Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation (2022) (1)
The PAK Signaling System Links Rho Gtpase Activation to Platelet Lamellopodia Formation, Aggregation and Aggregate Stability Under Shear (2012) (1)
PLATELETS AND THROMBOPOIESIS Pak 2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization (2015) (1)
Andrews Ofori Danso of Ghana (1977) (1)
Development and utility of a PAK1-selective degrader (2022) (1)
Analysis and manipulation of intracellular signaling cascades. (2004) (1)
Faculty Opinions recommendation of Phosphorylation networks regulating JNK activity in diverse genetic backgrounds. (2008) (1)
Therapeutics , Targets , and Chemical Biology p 21-Activated Kinase 1 Is Required for Ef fi cient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model (2012) (1)
HEMATOPOIESIS AND STEM CELLS p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with b -Pix (2016) (1)
Alfred G. Knudson (1922–2016) (2016) (1)
P21 activated kinase 1 (PAK1) protects heart from pressure overload induced pathological cardiac remodeling (2009) (1)
1 Attenuation of Airway Responsiveness in Pak 1 KO Mice. (2006) (0)
Abstract A40: Megakaryocyte endomitosis requires Pak2 to regulate actin and microtubule networks. (2015) (0)
Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1 (cid:1) / (cid:2) mast cells (2008) (0)
Faculty Opinions recommendation of Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (2005) (0)
A PTP1B-Cdk3 signaling axis promotes cell cycle progression of human glioblastoma cells through an Rb-E2F dependent pathway (2022) (0)
Abstract LB-011: PAK1 inhibitor FRAX1036 sensitizes ovarian cancer cells with amplified 11q13 to cytotoxic effect of rottlerin (2016) (0)
Abstract 1026: Role of Group I Paks in MPNST cell proliferation, migration and invasion (2015) (0)
Faculty Opinions recommendation of Protein kinase Cζ exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation. (2017) (0)
Induced Pluripotent Stem Cells as Potential Therapeutic Agents in NF1 (2011) (0)
The tumor suppressor Merlin regulates fatty acid synthesis thus providing a field for targeted pharmacotherapy of neurofibromatosis type II (2018) (0)
Peroxiredoxin-1 Protein Phosphorylation and Inactivation of Changes in the Cellular Redox State by The Tumor Suppressor Mst 1 Promotes Signal Transduction : (2013) (0)
Normal 0 0 Normal 0 0 Normal 0 0 Phenotype 50 100 Phenotype 42 100 Phenotype (2014) (0)
Author Correction: PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas (2018) (0)
Faculty Opinions recommendation of High-sensitivity measurements of multiple kinase activities in live single cells. (2014) (0)
Faculty Opinions recommendation of Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. (2013) (0)
Faculty Opinions recommendation of Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis. (2007) (0)
Abstract NTOC-087: DYNAMIC REPROGRAMMING OF THE KINOME OVERCOMES BET PROTEIN INHIBITION IN OVARIAN CANCER (2017) (0)
Faculty Opinions recommendation of The origins and genetic interactions of KRAS mutations are allele- and tissue-specific. (2021) (0)
mechanism in platelets -independent 3 -mediated Akt translocation to the membrane: a novel PIP q G (2014) (0)
Faculty Opinions recommendation of Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination. (2018) (0)
Abstract 2629: Single and combined inhibition of PAK and Hippo pathway in NF2-deficient schwannoma (2023) (0)
Abstract LB-001: Functional role of Pak1/Erk signaling in Rac1-related diseases (2016) (0)
Faculty Opinions recommendation of The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity. (2008) (0)
Identification of Protein Kinases Required for NF2 Signaling (2007) (0)
Development of left ventricular cardiac hypertrophy in a p21-activated kinase 1 knockout mouse model is mediated by Erk1 and PP2A. (2011) (0)
Faculty of 1000 evaluation for Differential effector engagement by oncogenic KRAS. (2018) (0)
Faculty of 1000 evaluation for Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins. (2018) (0)
Erk1-Mediated Development of Left Ventricular Cardiac Hypertrophy in a P21 Activated Kinase-1 (Pak1) Knockout Mouse Model (2011) (0)
SEARCH FOR NEW DRUGS SEARCH FOR CHEMICAL COMPOUNDS FOR PHARMACOTHERAPY OF NEUROFIBROMATOSIS TYPE 2 (2015) (0)
In Memoriam: Beatrice Mintz, PhD (1921–2022) (2022) (0)
Faculty Opinions recommendation of Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms. (2008) (0)
Pak2 Regulates MDSC Development and Function (2016) (0)
STK4 (serine/threonine kinase 4) (2011) (0)
Results Expression of RAC 1 P 29 S modifies zebrafish embryonic development and activates ERK through Group A PAKs (2018) (0)
Abstract 242: p21-Activated Kinase Regulates Vascular Smooth Muscle Migration Leading to Arterial Stenosis (2008) (0)
Pak A proteins are essential for hematopoietic stem/progenitor cell (HSC/P) engraftment through regulation of signaling pathways controlling HSC/P proliferation, survival, migration, and the actin cytoskeleton (2011) (0)
Faculty Opinions recommendation of A Universal Surrogate Reporter for Efficient Enrichment of CRISPR/Cas9-Mediated Homology-Directed Repair in Mammalian Cells. (2020) (0)
2020 in 20/20 hindsight (2021) (0)
Faculty Opinions recommendation of Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer. (2017) (0)
Faculty Opinions recommendation of Small-molecule hydrophobic tagging-induced degradation of HaloTag fusion proteins. (2011) (0)
2 Signal Transduction andMammalian Cell Growth : Problems and Paradigms (2005) (0)
Abstract B31: Pak1 and β-catenin inhibition blocks tumor progression in ErbB2-driven breast cancer models (2013) (0)
Abstract 2587: RAC1P29Sexpression in melanocytes is associated with increased DNA damage and altered cell cycle progression (2020) (0)
RAS family mutation patterns in a large cohort of CRCs. (2016) (0)
Paks integrate polarity and vesicle transport signaling in ovarian epithelial cancers (2016) (0)
Faculty Opinions recommendation of Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. (2021) (0)
Faculty Opinions recommendation of Precise manipulation of chromosomes in vivo enables genome-wide codon replacement. (2011) (0)
Cancer Discovery “In the Spotlight” A new Rho’d-map to diffuse gastric cancer (2020) (0)
Abstract 1086: Downstream kinase signaling is dictated by specific KRAS mutations (2020) (0)
Faculty Opinions recommendation of A pan-cancer proteomic perspective on The Cancer Genome Atlas. (2017) (0)
Abstract 1876: Reduced Pak1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition (2016) (0)
Faculty Opinions recommendation of Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase. (2007) (0)
Analysis of p21-Activated Kinase Function in Neurofibromatosis Type 2 (2007) (0)
Faculty Opinions recommendation of Identification of MRTX1133, a noncovalent, potent, and selective KRASG12D inhibitor. (2021) (0)
Abstract 1242: Combination of p21-activated kinase 1 (PAK1) inhibitor FRAX1036 and Aurora-A inhibitor alisertib is effective in hormone receptor-positive breast cancer (2016) (0)
Faculty Opinions recommendation of Enhancement of learning and memory after activation of cerebral Rho GTPases. (2007) (0)
Faculty Opinions recommendation of Inhibition of Lapatinib-Induced Kinome Reprogramming in ERBB2-Positive Breast Cancer by Targeting BET Family Bromodomains. (2017) (0)
How much is my paper worth? (2019) (0)
Faculty Opinions recommendation of Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. (2019) (0)
Decision letter: Extraction of active RhoGTPases by RhoGDI regulates spatiotemporal patterning of RhoGTPases (2019) (0)
Alfred G. Knudson Jr, MD, PhD: In Memoriam (1922-2016). (2017) (0)
Abstract B066: Unique roles of group I PAK isoforms in regulating MPNST cell viability (2018) (0)
Faculty Opinions recommendation of PAK4 inhibition improves PD-1 blockade immunotherapy. (2020) (0)
Faculty Opinions recommendation of Multiplexed in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity. (2018) (0)
Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer (2018) (0)
Faculty Opinions recommendation of PAK2 Haploinsufficiency Results in Synaptic Cytoskeleton Impairment and Autism-Related Behavior. (2018) (0)
775 THE MTOR PATHWAY IMPACTS PROLIFERATION AND CHEMOSENSITIVITY OF UROTHELIAL CARCINOMA CELLS IN VITRO AND IS HIGHLY EXPRESSED IN A SUBSET OF HUMAN BLADDER CANCERS (2010) (0)
Playing signaling chess with the KRAS oncogene (2017) (0)
TheFission YeastGenespypl+andpyp2+EncodeProtein Tyrosine Phosphatases ThatNegatively Regulate Mitosis (1992) (0)
Faculty Opinions recommendation of Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1P29S Melanoma Cells. (2019) (0)
Abstract 8840: P21-Activated Kinase Improves Myocardial Performance through Modulation of Troponin-T and Myosin Light Chain 2 during Global Myocardial Ischemia and Reperfusion Injury (2011) (0)
COMMENTARY Getting Smart about p21-Activated Kinases (2011) (0)
Targeting P21-Activated Kinase-1 for Metastatic Prostate Cancer (2023) (0)
Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Malignant Mesothelioma (2020) (0)
Kinase Activity Of Pak2, An Effector Of Rac/CDC42 and Its Interaction With β-PIX Is Required For Murine Hematopoietic Stem Cell Shape, F-Actin Formation, Directional Migration In Vitro and For HSPC Homing To Bone Marrow In Vivo (2013) (0)
Faculty Opinions recommendation of Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities. (2016) (0)
Group A Pak Proteins Are Essential for HSC/P Engraftment. (2010) (0)
1 Therapeutics, Targets, and Chemical Biology (2012) (0)
Faculty Opinions recommendation of Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer. (2020) (0)
Faculty Opinions recommendation of Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma. (2021) (0)
Role of p21-activated kinases in cardiovascular development and function (2013) (0)
Abstract A15: Megakaryocyte differentiation is regulated by p21-activated kinase 2 (2014) (0)
How to get and keep your lab funded (2018) (0)
Faculty Opinions recommendation of Pak1 control of E-cadherin endocytosis regulates salivary gland lumen size and shape. (2010) (0)
Faculty Opinions recommendation of Critical roles of phosphoinositides and NF2 in Hippo pathway regulation. (2021) (0)
Testing the Role of p21-Activated Kinases in Schwannoma Formation Using a Novel Genetically Engineered Murine Model that Closely Phenocopies Human NF2 Disease (2015) (0)
Faculty Opinions recommendation of Rapid diversification of cell signaling phenotypes by modular domain recombination. (2010) (0)
Faculty Opinions recommendation of A new family of RhoGEFs activates the Rop molecular switch in plants. (2005) (0)
Search for Chemical Compounds for Pharmacotherapy of Neurofibromatosis Type 2 (2015) (0)
Faculty Opinions recommendation of PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. (2005) (0)
Faculty Opinions recommendation of Quantifying the evolutionary dynamics of language. (2007) (0)
Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents (2015) (0)
COMMENTARY Getting Smart about p21-Activated Kinases (cid:1) (2011) (0)
A Facile Method to Engineer Mutant Kras Alleles in an Isogenic Cell Background. (2021) (0)
LOV conquers (sm)All GTPases (2010) (0)
Faculty Opinions recommendation of Identification of an oncogenic RAB protein. (2015) (0)
Gary M. Bokoch (1954–2010) (2010) (0)
Faculty Opinions recommendation of A kinome-wide screen using a NanoLuc LATS luminescent biosensor identifies ALK as a novel regulator of the Hippo pathway in tumorigenesis and immune evasion. (2019) (0)
Abstract A34: Defining KRAS mutation-specific kinome signatures and vulnerabilities in colorectal cancer (2020) (0)
Decision letter: Signaling levels mold the RAS mutation tropism of urethane (2021) (0)
Faculty Opinions recommendation of mTORC2 regulates cardiac response to stress by inhibiting MST1. (2015) (0)
Faculty of 1000 evaluation for Challenges in validating candidate therapeutic targets in cancer. (2018) (0)
Abstract A02: Pak1 kinase inhibition sensitizes 11q13 amplified breast cancer cells to platinum based chemotherapy via downregulation of Fanconi anemia genes (2014) (0)
Nonsteroidal sulfamate derivatives as new therapeutic approaches for Neurofibromatosis 2 (NF2) (2019) (0)
Faculty Opinions recommendation of Quantitative morphological signatures define local signaling networks regulating cell morphology. (2007) (0)
Faculty Opinions recommendation of Interconversion between intestinal stem cell populations in distinct niches. (2011) (0)
Faculty Opinions recommendation of RAC1P29S induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance. (2019) (0)
Mammalian sterile20-like kinase 1 (Mst1) exerts its tumor suppressor function through its downstream effector peroxiredoxin 1 (2014) (0)
Role of p21-activated kinases 1 and 2 in pseudorabies virus US3-mediated effects on apoptosis and nuclear egress (2010) (0)
Faculty Opinions recommendation of Inhibitor hijacking of Akt activation. (2009) (0)
Faculty Opinions recommendation of Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells. (2018) (0)
General/Theoretical Anthropology: Lives in Between: Assimilation and Marginality in Austria, Brazil, and West Africa, 1780–1945. Leo Spitzer. (1991) (0)
P-21 Activated Kinase 1 (Pak1) Is Critical for Normal Mast Cell Degranulation and Cytokine Production in Response to Antigen Stimulation of the High Affinity IgE Receptor. (2004) (0)
Ethnographic Highs: The Forest People & African Rhythm and African Sensibility (2017) (0)
Coming to Terms with Witchcraft (1990) (0)
Music of the Dagomba of Ghana (1984) (0)
African Rhythm: A Northern Ewe Perspective. Kofi Agawu (1997) (0)
Cote d'Ivoire: Music of the We (Guere)@@@Senegal: Le Saoruba de Casamance@@@Master Fiddlers of Dagbon@@@Nigeria: Griots Hausa@@@Mbum du Cameroun: Nord Cameroun (2003) (0)
Social/Cultural Anthropology: In Sorcery's Shadow: A Memoir of Apprenticeship Among the Songhay of Niger. Paul Stoller and Cheryl Olkes. (1988) (0)
A Day for the Hunter, a Day for the Prey: Popular Music and Power in Haiti (review) (2001) (0)
Life Within Limits: well-being in a world of want (review) (2012) (0)
Linguistic Anthropology: Dried Millet Breaking: Time, Words, and Song in the Woi Epic of the Kpelle. Ruth M. Stone (1989) (0)
REVIEW: Gage Averill.A DAY FOR THE HUNTER, A DAY FOR THE PREY: POPULAR MUSIC AND POWER IN HAITI, Chicago: U of Chicago P, 1997. (2001) (0)
Culture and the senses: bodily ways of knowing in an African community – By Kathryn Linn Geurts (2008) (0)
THREE KILOS OF COFFEE: AN AUTOBIOGRAPHY, by Manu Dibango, in collaboration with Danielle Rouard, translated by Beth G. Raps, Univ. of Chicago Press, Chicago and London, 1994, 146pp, index, discography, photographs. (1996) (0)
Midwest Society for Pediatric Research Abstracts and Index (2007) (0)

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