Jonathan Weissman
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Most Influential Person Now
Professor of Cellular Pharmacology and Biochemistry
Jonathan Weissman's AcademicInfluence.com Rankings
Jonathan Weissmanbiology Degrees
Biology
#1076
World Rank
#1850
Historical Rank
#562
USA Rank
Biochemistry
#376
World Rank
#449
Historical Rank
#145
USA Rank
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Biology
Jonathan Weissman's Degrees
- PhD Biochemistry University of California, San Francisco
- Bachelors Biochemistry University of California, Berkeley
Why Is Jonathan Weissman Influential?
(Suggest an Edit or Addition)According to Wikipedia, Jonathan S. Weissman is the Landon T. Clay Professor of Biology at the Massachusetts Institute of Technology, a member of the Whitehead Institute, and a Howard Hughes Medical Institute Investigator. From 1996 to 2020, he was a faculty member in the department of cellular molecular pharmacology at the University of California, San Francisco.
Jonathan Weissman's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Global analysis of protein localization in budding yeast (2003) (4281)
- Global analysis of protein expression in yeast (2003) (3862)
- Mammalian microRNAs predominantly act to decrease target mRNA levels (2010) (3839)
- Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression (2013) (3736)
- Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling (2009) (3121)
- Global landscape of protein complexes in the yeast Saccharomyces cerevisiae (2006) (2968)
- CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes (2013) (2839)
- Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation (2000) (1971)
- Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation (2014) (1951)
- Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes (2011) (1855)
- Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise (2006) (1503)
- Molecular Chaperones and Protein Quality Control (2006) (1485)
- The Human Cell Atlas (2017) (1285)
- The translational landscape of mTOR signalling steers cancer initiation and metastasis (2012) (1141)
- An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen (2009) (1119)
- A Protein-Tagging System for Signal Amplification in Gene Expression and Fluorescence Imaging (2014) (1089)
- Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System (2013) (1085)
- Quantifying Absolute Protein Synthesis Rates Reveals Principles Underlying Allocation of Cellular Resources (2014) (1016)
- The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments (2012) (993)
- Decay of Endoplasmic Reticulum-Localized mRNAs During the Unfolded Protein Response (2006) (989)
- Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens (2016) (920)
- Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map (2007) (908)
- Regulated Ire1-dependent decay of messenger RNAs in mammalian cells (2009) (894)
- Exploration of the Function and Organization of the Yeast Early Secretory Pathway through an Epistatic Miniarray Profile (2005) (889)
- CRISPR interference (CRISPRi) for sequence-specific control of gene expression (2013) (852)
- Cotranscriptional Set2 Methylation of Histone H3 Lysine 36 Recruits a Repressive Rpd3 Complex (2005) (821)
- Toward a Comprehensive Atlas of the Physical Interactome of Saccharomyces cerevisiae*S (2007) (799)
- Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds (2015) (783)
- Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System (2014) (773)
- Nascent transcript sequencing visualizes transcription at nucleotide resolution (2011) (761)
- Conformational variations in an infectious protein determine prion strain differences (2004) (759)
- Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo (2013) (699)
- A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response (2016) (678)
- Ribosome Profiling Provides Evidence that Large Noncoding RNAs Do Not Encode Proteins (2013) (662)
- Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum (2009) (633)
- The anti-Shine-Dalgarno sequence drives translational pausing and codon choice in bacteria (2012) (599)
- The physical basis of how prion conformations determine strain phenotypes (2006) (590)
- Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum (2011) (587)
- Oxidative protein folding in eukaryotes: mechanisms and consequences (2004) (580)
- A prudent path forward for genomic engineering and germline gene modification (2015) (565)
- Orm family proteins mediate sphingolipid homeostasis (2010) (544)
- Decoding Human Cytomegalovirus (2012) (533)
- CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells (2017) (525)
- A comprehensive strategy enabling high-resolution functional analysis of the yeast genome (2008) (515)
- Ribosome profiling reveals pervasive translation outside of annotated protein-coding genes. (2014) (513)
- Mechanism of Prion Propagation: Amyloid Growth Occurs by Monomer Addition (2004) (509)
- Reprogramming human T cell function and specificity with non-viral genome targeting (2017) (503)
- High-Resolution View of the Yeast Meiotic Program Revealed by Ribosome Profiling (2011) (494)
- Proto-genes and de novo gene birth (2012) (491)
- A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress (2012) (488)
- Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation (2016) (488)
- Oxidative protein folding in eukaryotes (2004) (481)
- A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria (2016) (479)
- The GET Complex Mediates Insertion of Tail-Anchored Proteins into the ER Membrane (2008) (461)
- A census of glutamine/asparagine-rich regions: implications for their conserved function and the prediction of novel prions. (2000) (446)
- Biochemical basis of oxidative protein folding in the endoplasmic reticulum. (2000) (442)
- Ero1p: a novel and ubiquitous protein with an essential role in oxidative protein folding in the endoplasmic reticulum. (1998) (438)
- Heat shock proteins and molecular chaperones: Mediators of protein conformation and turnover in the cell (1994) (427)
- A Luminal Surveillance Complex that Selects Misfolded Glycoproteins for ER-Associated Degradation (2006) (424)
- The FAD- and O(2)-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum. (2002) (421)
- Selective Ribosome Profiling Reveals the Cotranslational Chaperone Action of Trigger Factor In Vivo (2011) (420)
- Mechanism of GroEL action: Productive release of polypeptide from a sequestered position under groes (1995) (418)
- A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria (2011) (417)
- Characterization of the Active Intermediate of a GroEL–GroES-Mediated Protein Folding Reaction (1996) (392)
- Dynamic profiling of the protein life cycle in response to pathogens (2015) (381)
- CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs. (2016) (377)
- Conservation and Rewiring of Functional Modules Revealed by an Epistasis Map in Fission Yeast (2008) (356)
- Molecular Basis of Infrared Detection by Snakes (2010) (354)
- A Critical Role for Amino-Terminal Glutamine/Asparagine Repeats in the Formation and Propagation of a Yeast Prion (1998) (351)
- Ribosome profiling reveals the what, when, where and how of protein synthesis (2015) (345)
- A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility (2013) (336)
- Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster (2013) (334)
- GroEL-mediated protein folding proceeds by multiple rounds of binding and release of nonnative forms (1994) (332)
- The structural basis of yeast prion strain variants (2007) (332)
- A strategy for extracting and analyzing large-scale quantitative epistatic interaction data (2006) (327)
- Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling (2014) (321)
- Emerging principles of conformation-based prion inheritance. (2004) (318)
- Nucleosomes impede Cas9 access to DNA in vivo and in vitro (2016) (310)
- Targeting and plasticity of mitochondrial proteins revealed by proximity-specific ribosome profiling (2014) (305)
- The action of molecular chaperones in the early secretory pathway. (2001) (301)
- Multiple Gln/Asn-Rich Prion Domains Confer Susceptibility to Induction of the Yeast [PSI+] Prion (2001) (299)
- MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices (2019) (293)
- Pervasive functional translation of noncanonical human open reading frames (2020) (291)
- Single-cell analysis of long non-coding RNAs in the developing human neocortex (2016) (291)
- Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis. (2015) (282)
- Versatile protein tagging in cells with split fluorescent protein (2016) (276)
- Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae (2011) (274)
- Functional Organization of the S. cerevisiae Phosphorylation Network (2009) (271)
- Molecular Basis of a Yeast Prion Species Barrier (2000) (268)
- Deadly Conformations—Protein Misfolding in Prion Disease (1997) (267)
- A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. (2008) (266)
- DMS-MaPseq for genome-wide or targeted RNA structure probing in vivo (2016) (255)
- Amyloid structure: conformational diversity and consequences. (2011) (253)
- A Molecular Caliper Mechanism for Determining Very Long-Chain Fatty Acid Length (2007) (248)
- KSHV 2.0: A Comprehensive Annotation of the Kaposi's Sarcoma-Associated Herpesvirus Genome Using Next-Generation Sequencing Reveals Novel Genomic and Functional Features (2014) (246)
- A pause sequence enriched at translation start sites drives transcription dynamics in vivo (2014) (245)
- Small-molecule aggregates inhibit amyloid polymerization. (2008) (234)
- Defining the glycan destruction signal for endoplasmic reticulum-associated degradation. (2008) (233)
- Translation from unconventional 5′ start sites drives tumour initiation (2017) (233)
- Causal signals between codon bias, mRNA structure, and the efficiency of translation and elongation (2014) (233)
- Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing (2020) (227)
- Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen. (2005) (224)
- Membranes in balance: mechanisms of sphingolipid homeostasis. (2010) (215)
- Differential Scales of Protein Quality Control (2014) (212)
- Uniform nomenclature for the mitochondrial contact site and cristae organizing system (2014) (208)
- Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains (2015) (207)
- Molecular recording of mammalian embryogenesis (2018) (203)
- Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response (2015) (202)
- A tool-kit for high-throughput, quantitative analyses of genetic interactions in E. coli (2008) (192)
- Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats (2011) (191)
- Efficient catalysis of disulphide bond rearrangements by protein disulphide isomerase (1993) (189)
- Mapping the Genetic Landscape of Human Cells (2018) (186)
- Dissection and Design of Yeast Prions (2004) (184)
- Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing (2021) (180)
- A scalable strategy for high-throughput GFP tagging of endogenous human proteins (2016) (174)
- Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network (2008) (174)
- Mechanism of Cross-Species Prion Transmission An Infectious Conformation Compatible withTwo Highly Divergent Yeast Prion Proteins (2005) (170)
- A Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian Translation. (2015) (169)
- In vivo monitoring of the prion replication cycle reveals a critical role for Sis1 in delivering substrates to Hsp104. (2008) (167)
- Enhanced prime editing systems by manipulating cellular determinants of editing outcomes (2021) (162)
- Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent (2017) (159)
- Functional Repurposing Revealed by Comparing S. pombe and S. cerevisiae Genetic Interactions (2012) (152)
- Evidence for the prion hypothesis: induction of the yeast [PSI+] factor by in vitro- converted Sup35 protein. (2000) (152)
- High-throughput genetic interaction mapping in the fission yeast Schizosaccharomyces pombe (2007) (151)
- Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing (2020) (150)
- Cellular noise regulons underlie fluctuations in Saccharomyces cerevisiae. (2012) (150)
- Inducible and multiplex gene regulation using CRISPR-Cpf1-based transcription factors (2017) (149)
- The SND proteins constitute an alternative targeting route to the endoplasmic reticulum (2016) (148)
- The mTOR Complex Controls HIV Latency. (2016) (148)
- Ribosome Profiling: Global Views of Translation. (2018) (148)
- Backup without redundancy: genetic interactions reveal the cost of duplicate gene loss (2007) (146)
- The general mode of translation inhibition by macrolide antibiotics (2014) (142)
- Directed Evolution of Substrate-Optimized GroEL/S Chaperonins (2002) (137)
- Conformational diversity in a yeast prion dictates its seeding specificity (2001) (137)
- Defining the physiological role of SRP in protein-targeting efficiency and specificity (2018) (137)
- Mec1/Tel1 Phosphorylation of the INO80 Chromatin Remodeling Complex Influences DNA Damage Checkpoint Responses (2007) (134)
- Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids. (2019) (133)
- The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins (2018) (128)
- Origins and kinetic consequences of diversity in Sup35 yeast prion fibers (2002) (127)
- The Coding and Noncoding Architecture of the Caulobacter crescentus Genome (2014) (126)
- A general lack of compensation for gene dosage in yeast (2010) (125)
- Cotranscriptional Set 2 Methylation of Histone H 3 Lysine 36 Recruits a Repressive Rpd 3 Complex (2005) (124)
- Regulation of mRNA translation during mitosis (2015) (123)
- Analysis of Dom34 and its function in no-go decay. (2009) (123)
- Operon mRNAs are organized into ORF-centric structures that predict translation efficiency (2017) (119)
- Plastid: nucleotide-resolution analysis of next-generation sequencing and genomics data (2016) (115)
- Exploring genetic interaction manifolds constructed from rich single-cell phenotypes (2019) (114)
- A Stress Response that Monitors and Regulates mRNA Structure Is Central to Cold Shock Adaptation. (2018) (112)
- The pro region of BPTI facilitates folding (1992) (112)
- Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts (2020) (112)
- Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells (2013) (111)
- Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure (2013) (110)
- A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation (2014) (107)
- The helicase Ded1p controls use of near-cognate translation initiation codons in 5′UTRs (2018) (106)
- Rapid Creation and Quantitative Monitoring of High Coverage shRNA Libraries (2009) (106)
- Selective ribosome profiling as a tool for studying the interaction of chaperones and targeting factors with nascent polypeptide chains and ribosomes (2013) (104)
- CCR4/NOT complex associates with the proteasome and regulates histone methylation (2007) (101)
- Mapping Transcriptomic Vector Fields of Single Cells (2019) (95)
- Quantitative genetic analysis in Saccharomyces cerevisiae using epistatic miniarray profiles (E-MAPs) and its application to chromatin functions. (2006) (94)
- Validation of the Hsp70–Bag3 Protein–Protein Interaction as a Potential Therapeutic Target in Cancer (2015) (93)
- Generation of prion transmission barriers by mutational control of amyloid conformations (2003) (93)
- Native Elongating Transcript Sequencing (NET‐seq) (2012) (91)
- Construction, Verification and Experimental Use of Two Epitope-Tagged Collections of Budding Yeast Strains (2005) (90)
- Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq (2021) (89)
- Aneuploid yeast strains exhibit defects in cell growth and passage through START (2013) (89)
- Domain Architecture of Protein-disulfide Isomerase Facilitates Its Dual Role as an Oxidase and an Isomerase in Ero1p-mediated Disulfide Formation*♦ (2006) (89)
- CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides (2017) (89)
- Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity (2016) (87)
- An expanded universe of cancer targets (2021) (86)
- Kinetic role of nonnative species in the folding of bovine pancreatic trypsin inhibitor. (1992) (86)
- Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation (2016) (85)
- Release of both native and non-native proteins from a cis-only GroEL ternary complex (1996) (85)
- Next-generation libraries for robust RNA interference-based genome-wide screens (2015) (84)
- Genetic Influences on Translation in Yeast (2014) (80)
- H3K4 Trimethylation by Set1 Promotes Efficient Termination by the Nrd1-Nab3-Sen1 Pathway (2011) (79)
- A kinetic explanation for the rearrangement pathway of BPTI folding (1995) (78)
- Automated identification of pathways from quantitative genetic interaction data (2010) (78)
- A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern (2013) (77)
- Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps (2014) (76)
- GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control (2019) (74)
- Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. (1995) (74)
- Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits (2015) (74)
- Lipid Homeostasis Is Maintained by Dual Targeting of the Mitochondrial PE Biosynthesis Enzyme to the ER. (2017) (74)
- Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs (2019) (74)
- Differences in prion strain conformations result from non-native interactions in a nucleus. (2010) (73)
- Genome-wide annotation and quantitation of translation by ribosome profiling. (2013) (70)
- Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. (2013) (69)
- Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70). (2018) (69)
- Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning (2021) (68)
- OpenCell: Endogenous tagging for the cartography of human cellular organization (2022) (66)
- GroEL-GroES-mediated protein folding requires an intact central cavity. (1998) (63)
- Global cellular response to chemotherapy-induced apoptosis (2013) (62)
- MULTI-seq: Scalable sample multiplexing for single-cell RNA sequencing using lipid-tagged indices (2018) (60)
- Mapping the genetic landscape of DNA double-strand break repair (2021) (59)
- Extensive and coordinated control of allele-specific expression by both transcription and translation in Candida albicans (2014) (58)
- The utility of prions. (2002) (58)
- rRNA:mRNA pairing alters the length and the symmetry of mRNA-protected fragments in ribosome profiling experiments (2013) (57)
- High-content CRISPR screening (2022) (56)
- Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins (2018) (56)
- CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma (2019) (56)
- Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform (2018) (55)
- The Human Cell Atlas White Paper (2018) (55)
- Identification of yeast proteins necessary for cell-surface function of a potassium channel (2007) (54)
- CRISPR Approaches to Small Molecule Target Identification. (2017) (53)
- Cycloheximide can distort measurements of mRNA levels and translation efficiency (2019) (52)
- Inference of single-cell phylogenies from lineage tracing data using Cassiopeia (2019) (52)
- Design and specificity of long ssDNA donors for CRISPR-based knock-in (2017) (50)
- Structured elements drive extensive circular RNA translation. (2021) (50)
- An efficient protein transformation protocol for introducing prions into yeast. (2006) (49)
- Msn2 Coordinates a Stoichiometric Gene Expression Program (2013) (48)
- J Domain Co-chaperone Specificity Defines the Role of BiP during Protein Translocation* (2010) (48)
- Unraveling the mechanism of cell death induced by chemical fibrils (2014) (46)
- Dynamic translation regulation in Caulobacter cell cycle control (2016) (45)
- Suppression of B-cell development genes is key to glucocorticoid efficacy in treatment of acute lymphoblastic leukemia. (2017) (42)
- High-content imaging-based pooled CRISPR screens in mammalian cells (2020) (40)
- From the cradle to the grave: ring complexes in the life of a protein. (1995) (40)
- Strain conformation, primary structure and the propagation of the yeast prion [PSI+] (2011) (40)
- Guide to yeast genetics : functional genomics, proteomics, and other systems analysis (2010) (39)
- Systematic Screen of Schizosaccharomyces pombe Deletion Collection Uncovers Parallel Evolution of the Phosphate Signal Transduction Pathway in Yeasts (2010) (39)
- Thinking outside the box: new insights into the mechanism of GroEL-mediated protein folding (1999) (37)
- Functional single-cell genomics of human cytomegalovirus infection (2019) (37)
- Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients (2020) (37)
- Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution (2022) (37)
- Conserved Functions of Ether Lipids and Sphingolipids in the Early Secretory Pathway (2020) (37)
- Deep profiling reveals substantial heterogeneity of integration outcomes in CRISPR knock-in experiments (2019) (35)
- The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins (2019) (35)
- Mismatch-CRISPRi Reveals the Co-varying Expression-Fitness Relationships of Essential Genes in Escherichia coli and Bacillus subtilis. (2020) (35)
- A CRISPR/Cas9-engineered ARID1A-deficient human gastric cancer organoid model reveals essential and non-essential modes of oncogenic transformation. (2021) (34)
- Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether (2019) (34)
- Standardized annotation of translated open reading frames (2022) (31)
- Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates (2018) (31)
- Systems biology: Reverse engineering the cell (2008) (31)
- Putting a lid on protein folding: structure and function of the co-chaperonin, GroES. (1996) (30)
- Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span (2020) (30)
- Oncogenic activation of the PI3-kinase p110β isoform via the tumor-derived PIK3CβD1067V kinase domain mutation (2016) (29)
- All roads lead to Rome? The multiple pathways of protein folding. (1995) (26)
- Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress (2019) (25)
- The dark proteome: translation from noncanonical open reading frames (2021) (25)
- Enclosed chambers for humidity control and sample containment in fiber diffraction (2008) (24)
- Construction of single-ring and two-ring hybrid versions of bacterial chaperonin GroEL. (1998) (23)
- Htm1p–Pdi1p is a folding-sensitive mannosidase that marks N-glycoproteins for ER-associated protein degradation (2016) (23)
- Combined chemical–genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma (2016) (23)
- BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2 (2021) (22)
- Mapping Vector Field of Single Cells (2019) (21)
- OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization (2021) (21)
- Approaches to maximize sgRNA-barcode coupling in Perturb-seq screens (2018) (21)
- Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes (2020) (20)
- Cellular response to small molecules that selectively stall protein synthesis by the ribosome (2018) (20)
- New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells (2019) (20)
- Model-guided optogenetic study of PKA signaling in budding yeast (2017) (17)
- Systems Biology: Many things from one (2006) (17)
- From information to knowledge: new technologies for defining gene function (2009) (15)
- Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression (2021) (15)
- Engineering ER-stress dependent non-conventional mRNA splicing (2018) (14)
- Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent (2020) (14)
- BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2 (2021) (13)
- Response to Comment on “Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling” (2015) (13)
- Radically different amyloid conformations dictate the seeding specificity of a chimeric Sup35 prion. (2011) (13)
- Transforming Big Data into Cancer-Relevant Insight: An Initial, Multi-Tier Approach to Assess Reproducibility and Relevance (2016) (12)
- Peroxisome function relies on organelle-associated mRNA translation (2022) (12)
- The contribution of systematic approaches to characterizing the proteins and functions of the endoplasmic reticulum. (2013) (12)
- Special issue: the molecular and cellular mechanisms of amyloidosis. (2012) (12)
- Functional genomic approaches to understanding molecular chaperones and stress responses. (2001) (12)
- Validation of the Hsp 70-Bag 3 Protein-Protein Interaction as a Potential Therapeutic Target in Cancer (2014) (11)
- Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells (2021) (11)
- Comparison of three full-reference color image quality measures (2006) (11)
- A community-driven roadmap to advance research on translated open reading frames detected by Ribo-seq (2021) (11)
- Regulation of translation by methylation multiplicity of 18S rRNA (2021) (11)
- Plastid: nucleotide-resolution analysis of next-generation sequencing and genomics data (2016) (10)
- Author response: The Human Cell Atlas (2017) (10)
- Direct capture of CRISPR guides enables scalable, multiplexed, and multi-omic Perturb-seq (2018) (10)
- The microtubule regulator ringer functions downstream from the RNA repair/splicing pathway to promote axon regeneration (2020) (10)
- Heterogeneity and targeted therapy-induced adaptations in lung cancer revealed by longitudinal single-cell RNA sequencing (2019) (9)
- Author response: Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation (2016) (9)
- [KIL-d] Protein Element Confers Antiviral Activity via Catastrophic Viral Mutagenesis. (2015) (9)
- The ins and outs of GroEL-mediated protein folding. (2001) (9)
- MTCH2 is a mitochondrial outer membrane protein insertase (2022) (9)
- Exploring genetic interaction manifolds constructed from rich phenotypes (2019) (8)
- Modulated efficacy CRISPRi reveals evolutionary conservation of essential gene expression-fitness relationships in bacteria (2019) (8)
- Lineage Recording Reveals the Phylodynamics, Plasticity and Paths of Tumor Evolution (2021) (7)
- Integrated genomic analysis by whole exome and transcriptome sequencing of tumor samples from EGFR-mutant non-small-cell lung cancer (NSCLC) patients (p) with acquired resistance to erlotinib. (2013) (6)
- Genetics: Noise rules (2011) (6)
- Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors (2022) (6)
- Variant to function mapping at single-cell resolution through network propagation (2022) (6)
- Microfluidics-free single-cell genomics with templated emulsification (2022) (6)
- Cellular barcoding to decipher clonal dynamics in disease (2022) (5)
- Misfolded Proteins Induce Aggregation of the Lectin Yos9* (2014) (5)
- Correction: Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster (2014) (5)
- Single-cell analysis of long non-coding RNAs in the developing human neocortex (2016) (5)
- An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens (2021) (5)
- Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice (2022) (4)
- Target-specific DMS-MaPseq for in vivo RNA structure determination (2016) (4)
- Resource Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression (2013) (4)
- A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activities. (2022) (4)
- Author response: Regulation of mRNA translation during mitosis (2015) (4)
- Coupled protein quality control during nonsense mediated mRNA decay (2021) (4)
- Genome-wide DMS-MaPseq for in vivo RNA structure determination (2016) (4)
- Homeostatic Regulation The Unfolded Protein Response : From Stress Pathway to (2011) (4)
- Polysomes Bypass a 50-Nucleotide Coding Gap Less Efficiently Than Monosomes Due to Attenuation of a 5′ mRNA Stem–Loop and Enhanced Drop-off (2020) (4)
- A rogue protein (2001) (3)
- Variant to function mapping at single-cell resolution through network propagation (2022) (3)
- Reprogramming human T cell function and specificity with non-viral genome targeting (2018) (3)
- Correction of autoimmune IL2RA mutations in primary human T cells using non-viral genome targeting (2017) (3)
- Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seq (2022) (3)
- Spateo: multidimensional spatiotemporal modeling of single-cell spatial transcriptomics (2022) (3)
- Dual genome-wide coding and lncRNA screens in neural induction of induced pluripotent stem cells (2022) (3)
- Kinesis of polypeptide during GroEL-mediated folding. (1995) (3)
- Titrating gene expression with series of systematically compromised CRISPR guide RNAs (2019) (3)
- A Luminal Surveillance Complex that Selects Misfolded Glycoproteins for ER Associated Degradation (2007) (3)
- Adaptive exchange sustains cullin–RING ubiquitin ligase networks and proper licensing of DNA replication (2022) (3)
- Construction, verification and experimental use of two epitope-tagged collections of budding yeast strains: Research Papers (2005) (2)
- Resource A Comprehensive , CRISPR-based Functional Analysis of Essential Genes in Bacteria Graphical Abstract Highlights (2)
- Membrane Insertion of Tail-anchored Proteins (2010) (2)
- Conserved function of ether lipids and sphingolipids in the early secretory pathway (2019) (2)
- Continuous lineage recording reveals rapid, multidirectional metastasis in a lung cancer xenograft model in mouse (2020) (2)
- Prion diseases. A rogue protein. (2001) (2)
- Genome-Scale Perturbation of Long Noncoding RNA Expression Using CRISPR Interference. (2021) (2)
- Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs (2020) (2)
- Author response: Nucleosomes impede Cas9 access to DNA in vivo and in vitro (2016) (2)
- CRISPR-based functional genomics in human dendritic cells (2020) (2)
- Integrated genomic analysis of EGFR-mutant non-small cell lung cancer immediately following erlotinib initiation in patients. (2013) (2)
- Abstract 4766: Translation from unconventional 5' start sites drives tumor initiation (2017) (2)
- Author response: Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response (2015) (2)
- Next-Generation NAMPT Inhibitors For ALL Identified By Sequential High-Throughput Phenotypic Chemical and Functional Genomic Screens (2013) (1)
- Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress (2022) (1)
- Inducible, tunable and multiplex human gene regulation using CRISPR-Cpf1-based transcription factors (2017) (1)
- Comparative landscape of genetic dependencies in human and chimpanzee stem cells (2023) (1)
- Author response: Operon mRNAs are organized into ORF-centric structures that predict translation efficiency (2017) (1)
- Simulating the Pulling of Stalled Elongated Peptide from the Ribosome by the Translocon (2014) (1)
- Abstract PR05: Using genome-scale CRISPR-mediated loss-of-function and gain-of-function screens to analyze gene-drug interactions in cancer (2015) (1)
- The Epistemology of Cell Biology (2010) (1)
- Inference of single-cell phylogenies from lineage tracing data using Cassiopeia (2020) (1)
- Author response: CRISPR-based functional genomics in human dendritic cells (2021) (1)
- Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal 1 effectors 2 3 (2022) (0)
- Monitoring Protein Synthesis One Codon at a Time through Ribosome Profiling (2013) (0)
- discovered in yeast , and a host of new tools and synthetic engineered systems . Massively Parallel Single-Cell Writing (2017) (0)
- Abstract A2-12: Opposing roles of the 19S regulatory and 20S core proteasomal subunits in controlling sensitivity to proteasome inhibitors (2015) (0)
- Development of a set of C•G-to-G•C transversion base editors from CRISPRi screens, target-library analysis, and machine learning (2022) (0)
- Assen Roguev , Revealed by an Epistasis Map in Fission Yeast Conservation and Rewiring of Functional Modules (2008) (0)
- Decision letter: Translation affects mRNA stability in a codon-dependent manner in human cells (2019) (0)
- Sterol Regulation of Metabolism , Homeostasis , and Development (2017) (0)
- Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes (2020) (0)
- Cryo-EM structure of Saccharomyces cerevisiae ER membrane protein complex bound to Fab-DH4 in lipid nanodiscs (2020) (0)
- Author response: Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits (2015) (0)
- Quantifying the Spatial Organization of Bacterial Ribosomes using Three-Dimensional Super-Resolution Microscopy (2014) (0)
- New Tools for Lineage Tracing in Cancer In Vivo (2023) (0)
- Abstract 954: Integrated genomic analysis by whole exome and transcriptome sequencing of tumor samples from EGFR-mutant non-small-cell lung cancer patients with acquired resistance to erlotinib (2014) (0)
- Abstract A2-56: Cancer-specific synthetic lethality and network rewiring elucidated by genetic interaction maps and CRISPR-based gain- and loss-of-function screens (2015) (0)
- Clinical validation of a comprehensive cancer genomics analysis for lung cancer patients. (2014) (0)
- Biophysics: All seeing eye (2009) (0)
- The ER membrane protein complex is important for the biogenesis of flavivirus polyproteins (2019) (0)
- Deadly Conformations—Protein Review Misfolding in Prion Disease (1997) (0)
- Correction: Global cellular response to chemotherapy-induced apoptosis (2013) (0)
- Corrigendum: Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps (2015) (0)
- The ER membrane protein complex is important for the biogenesis of flavivirus polyproteins (2019) (0)
- Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing (2020) (0)
- A genome-wide high-complexity shRNA library screen identifies novel factors in MHC class I trafficking and degradation (2015) (0)
- Globally monitoring protein synthesis in time and space through ribosome profiling (2016) (0)
- Identification and characterization of a transporter complex responsible for the cytosolic entry of nitrogen-containing-bisphosphonates (2018) (0)
- CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma (2020) (0)
- Supplementary table 3 - readthrough statistics for Saccharomyces cerevisiae (2013) (0)
- Unraveling the Mechanism of Cell Death Induced by Chemical and Protein Fibrils (2014) (0)
- Ribosome Profiling of the Caulobacter Cell-Cycle (2014) (0)
- Integrated genomic analysis for revealing broad remodeling of EGFR-targeted therapy resistant lung cancers. (2014) (0)
- Decision letter: Stop codon context influences genome-wide stimulation of termination codon readthrough by aminoglycosides (2019) (0)
- Proteins and Functions of the Endoplasmic Reticulum The Contribution of Systematic Approaches to Characterizing the (2013) (0)
- Abstract C01: Systematic blueprinting of genetic vulnerabilities using ultra-complex shRNA libraries identifies genes synergizing with proteasome inhibition or blockade of IRE1 in multiple myeloma cells (2013) (0)
- Polysomes Bypa Coding Gap Les Monosomes Due a 5′ mRNA Stem Enhanced Drop- (0)
- Elucidating Ribosomal Translocation with Internal Coordinate Flexible Fitting (2014) (0)
- Cryo-EM structure of Saccharomyces cerevisiae ER membrane protein complex bound to a Fab in DDM detergent (2020) (0)
- H3K4 Trimethylation by Set1 Promotes Efficient Termination by the Nrd1-Nab3-Sen1 Pathway (cid:1) † (2011) (0)
- Insights into the Nature of Yeast Prions (2008) (0)
- Author response: Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether (2019) (0)
- Selective Targeting of Ras Mutant Cancers via a New Small Molecule (2020) (0)
- Translocation the Role of BiP during Protein J Domain Co-chaperone Specificity Defines Protein Synthesis and Degradation : (2010) (0)
- Current Protocols in Molecular Biology BASIC PROTOCOL RIBOSOME PROFILING IN CULTURED MAMMALIAN CELLS (2013) (0)
- Monitoring Translation in Space and Time with Ribosome Profiling (2016) (0)
- Cryo-EM structure of human ER membrane protein complex in GDN detergent (2020) (0)
- MA11.09 Single-Cell Characterization of the Immunologic Microenvironment in Advanced-Stage, Oncogene-Driven NSCLC (2018) (0)
- Globally monitoring translation one codon at a time through ribosome profiling (231.1) (2014) (0)
- Versatile protein tagging with split fluorescence protein: a scalable strategy for GFP tagging of endogenous human proteins (2016) (0)
- Abstract A43: Opposing roles of the 19S regulatory- and 20S core-proteasomal subunits in controlling sensitivity of multiple myeloma cells to proteasome inhibition. (2015) (0)
- Article Msn2 Coordinates a Stoichiometric Gene Expression Program (2013) (0)
- Mandegar et al - Supplemental (2016) (0)
- Genetic influences on translation in yeast (2014) (0)
- Cryo-EM structure of human ER membrane protein complex in lipid nanodiscs (2020) (0)
- both transcription and translation in Candida albicans Extensive and coordinated control of allele-specific expression by Material Supplemental (2014) (0)
- Abstract PR06: Systematic genetic interaction maps reveal synthetic-lethal vulnerabilities in leukemia and multiple myeloma (2013) (0)
- Noise in Gene Expression Reveals Cellular Pathways (2005) (0)
- A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens (2023) (0)
- Abstract IA20: Monitoring translation in space and time with ribosome profiling (2017) (0)
- Unraveling the Mechanism of SBRT Response in EGFR-Addicted Pulmonary Adenocarcinoma by CRISPR/Cas9 Functional Genomics (2015) (0)
- Visualizing Transcription In Vivo at Nucleotide Resolution using Nascent Transcript Sequencing (2012) (0)
- Translational fidelity screens in mammalian cells reveal eIF3 and eIF4G2 as regulators of start codon selectivity. (2023) (0)
- GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion–positive rhabdomyosarcoma (2022) (0)
- Abstract PR07: Systematic genetic interaction maps reveal rewiring of the stress response network and resulting vulnerabilities in leukemia and multiple myeloma cells (2013) (0)
- Abstract A08: Systematic identification of genetic vulnerabilities synergizing with proteasome and IRE1 inhibition in multiple myeloma cells using ultra-complex shRNA libraries (2013) (0)
- Abstract 4707: Comprehensive integrated genomic analysis (2014) (0)
- Resource Mapping the Genetic Landscape of Human Cells Graphical (2018) (0)
- Eliminating Ultracentrifugation in the Deep Sequencing of Ribosome-Protected mRNA Fragments Using Polysomes and Monosomes (2012) (0)
- Sa134 A CRISPR/CAS9-ENGINEERED ARID1A-DEFICIENT HUMAN GASTRIC CANCER ORGANOID MODEL REVEALS ESSENTIAL AND NON-ESSENTIAL MODES OF ONCOGENIC TRANSFORMATION (2021) (0)
- Protein Structure and Biology (2013) (0)
- MOLECULAR CHAPERONES & STRESS RESPONSES (2010) (0)
- Genome‐wide screens in yeast reveal that diverse cellular pathways influence the toxicity of various neurodegenerative disease‐associated misfolded proteins (2010) (0)
- ASCB 50TH ANNIVERSARY ESSAY The Epistemology of Cell Biology (2010) (0)
- Abstract IA27: Retooling CRISPR to turn genes on and off (2016) (0)
- Neuroscience: Brain signal source (2009) (0)
- The helicase Ded1p controls use of near-cognate translation initiation codons in 5′ UTRs (2018) (0)
- GENT-49. SYSTEMATIC IDENTIFICATION OF ESSENTIAL LONG NON-CODING RNA GENES IN GLIOBLASTOMA (2016) (0)
- the meiotic chromosome segregation pattern A developmentally regulated translational control pathway establishes Material Supplemental (2013) (0)
- Abstract A2-57: Identification of genetic vulnerabilities within the proteostasis network of multiple myeloma (2015) (0)
- Finding and Interpreting Genetic Interactions using Perturb-Seq Single Cell RNA-Seq CRISPR Screens (2019) (0)
- Abstract IA23: Single cell-resolution lineage tracing of tumors in a mouse xenograft model reveals rapid and multidirectional metastasis (2020) (0)
- Author response: Global cellular response to chemotherapy-induced apoptosis (2013) (0)
- proximity-specific ribosome profiling Targeting and plasticity of mitochondrial proteins revealed (2014) (0)
- Translational Control of the Caulobacter Cell Cycle (2014) (0)
- Assembly of a phased diploid Candida albicansgenome facilitates allele-specific measurements and provides a simple model for repeat and indel structure (2013) (0)
- Abstract 123: A CRISPR/Cas9-engineered ARID1A-deficient human gastric cancer organoid model reveals essential and non-essential modes of oncogenic transformation (2021) (0)
- Abstract IA05: Massively parallel search for synthetic lethal vulnerabilities using CRISPRi and CRISPRa (2017) (0)
- Molecular recording of mammalian embryogenesis (2019) (0)
- Sexual selection: Intruder alert! (2009) (0)
- Genome-Scale Screening for Functional lncRNAs (2017) (0)
- Journal club (2009) (0)
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