Jorge H. Capdevila
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Chemistry Biology
Jorge H. Capdevila's Degrees
- PhD Biochemistry University of California, Berkeley
- Masters Chemistry University of California, Berkeley
- Bachelors Chemistry University of California, Berkeley
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(Suggest an Edit or Addition)Jorge H. Capdevila's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. (2000) (559)
- Soluble Epoxide Hydrolase Inhibition Lowers Arterial Blood Pressure in Angiotensin II Hypertension (2002) (398)
- Human cytochromes P450 (1999) (303)
- Cytochrome P450 and the arachidonate cascade 1 (1992) (294)
- Liver microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid. (1981) (268)
- Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension (2001) (247)
- Regio- and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase. (1993) (219)
- The CYP4A Isoforms Hydroxylate Epoxyeicosatrienoic Acids to Form High Affinity Peroxisome Proliferator-activated Receptor Ligands* (2002) (215)
- Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism. (1988) (202)
- Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet. (1994) (190)
- Functional Variant of CYP4A11 20-Hydroxyeicosatetraenoic Acid Synthase Is Associated With Essential Hypertension (2005) (187)
- The reaction of arachidonic acid epoxides (epoxyeicosatrienoic acids) with a cytosolic epoxide hydrolase. (1983) (176)
- Intestinal vasodilation by epoxyeicosatrienoic acids: arachidonic acid metabolites produced by a cytochrome P450 monooxygenase. (1987) (173)
- An Active Site Substitution, F87V, Converts Cytochrome P450 BM-3 into a Regio- and Stereoselective (14S,15R)-Arachidonic Acid Epoxygenase* (1997) (170)
- Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform. (1995) (165)
- Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets. (1983) (164)
- Characterization of 5,6- and 8,9-Epoxyeicosatrienoic Acids (5,6- and 8,9-EET) as Potent in Vivo Angiogenic Lipids* (2005) (164)
- Cytochrome P450 Epoxygenase Metabolism of Arachidonic Acid Inhibits Apoptosis (2001) (161)
- The Highly Stereoselective Oxidation of Polyunsaturated Fatty Acids by Cytochrome P450BM-3* (1996) (160)
- Colon Carcinoma Cell Growth Is Associated with Prostaglandin E2/EP4 Receptor-evoked ERK Activation* (2004) (151)
- Endogenous epoxyeicosatrienoyl-phospholipids. A novel class of cellular glycerolipids containing epoxidized arachidonate moieties. (1991) (151)
- Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. (2006) (142)
- Epoxyeicosatrienoic Acids and Their Sulfonimide Derivatives Stimulate Tyrosine Phosphorylation and Induce Mitogenesis in Renal Epithelial Cells* (1998) (140)
- Cytochrome P450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system (1996) (138)
- The kidney cytochrome P-450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading. (1999) (135)
- Cytochrome P-450 arachidonic acid epoxygenase. Regulatory control of the renal epoxygenase by dietary salt loading. (1992) (135)
- Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase. (1990) (134)
- Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. (1982) (132)
- The CYP P450 arachidonic acid monooxygenases: from cell signaling to blood pressure regulation. (2001) (129)
- Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450. (1986) (128)
- The oxidative metabolism of arachidonic acid by purified cytochromes P-450. (1981) (126)
- Epoxygenase Metabolites Contribute to Nitric Oxide-Independent Afferent Arteriolar Vasodilation in Response to Bradykinin (2001) (125)
- Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis. (1995) (124)
- Inhibition of cardiac L-type calcium channels by epoxyeicosatrienoic acids. (1999) (124)
- Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension. (2007) (122)
- Vasoactivity of arachidonic acid epoxides. (1987) (122)
- Androgens augment proximal tubule transport. (2004) (120)
- The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s). (1995) (120)
- Transfection of an Active Cytochrome P450 Arachidonic Acid Epoxygenase Indicates That 14,15-Epoxyeicosatrienoic Acid Functions as an Intracellular Second Messenger in Response to Epidermal Growth Factor* (1999) (119)
- Biochemical and molecular properties of the cytochrome P450 arachidonic acid monooxygenases. (2002) (115)
- The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: characterization and significance. (1995) (111)
- Cytochrome P-450-dependent oxygenation of arachidonic acid to hydroxyicosatetraenoic acids. (1982) (108)
- Action of luteinizing hormone-releasing hormone: involvement of novel arachidonic acid metabolites. (1983) (108)
- Purification and biochemical characterization of two major cytochrome P-450 isoforms induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in chick embryo liver. (1994) (105)
- Arachidonic acid epoxygenase: structural characterization and quantification of epoxyeicosatrienoates in plasma. (1992) (102)
- Peroxisomal Proliferator-activated Receptor-α-dependent Inhibition of Endothelial Cell Proliferation and Tumorigenesis* (2007) (102)
- Epoxyeicosatrienoic acids activate Na+/H+ exchange and are mitogenic in cultured rat glomerular mesangial cells (1990) (102)
- Androgen-mediated induction of the kidney arachidonate hydroxylases is associated with the development of hypertension. (2003) (94)
- CYP3A4 Mediates Growth of Estrogen Receptor-positive Breast Cancer Cells in Part by Inducing Nuclear Translocation of Phospho-Stat3 through Biosynthesis of (±)-14,15-Epoxyeicosatrienoic Acid (EET)* (2011) (94)
- Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase. (1993) (93)
- Heparin-binding EGF-like growth factor mediates the biological effects of P450 arachidonate epoxygenase metabolites in epithelial cells (2002) (88)
- Cytochrome P-450 arachidonate metabolites in rat kidney: characterization and hemodynamic responses. (1990) (88)
- 20-HETE Signals Through G-Protein–Coupled Receptor GPR75 (Gq) to Affect Vascular Function and Trigger Hypertension (2017) (87)
- Cytochrome P-450 arachidonate oxygenase. (1990) (86)
- Cytochrome P-450-dependent oxidation of arachidonic acid to 16-, 17-, and 18-hydroxyeicosatetraenoic acids. (1990) (85)
- Endogenous epoxyeicosatrienoic acids. Cytochrome P-450 controlled stereoselectivity of the hepatic arachidonic acid epoxygenase. (1989) (83)
- The Anti-tumorigenic Properties of Peroxisomal Proliferator-activated Receptor α Are Arachidonic Acid Epoxygenase-mediated* (2010) (78)
- Identification of Novel Endogenous Cytochrome P450 Arachidonate Metabolites with High Affinity for Cannabinoid Receptors* (2008) (77)
- 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition. (2009) (76)
- The T8590C Polymorphism of CYP4A11 and 20-Hydroxyeicosatetraenoic Acid in Essential Hypertension (2008) (73)
- Differentiating Keratinocytes Express a Novel Cytochrome P450 Enzyme, CYP2B19, Having Arachidonate Monooxygenase Activity* (1998) (72)
- 5,6-EET inhibits ion transport in collecting duct by stimulating endogenous prostaglandin synthesis. (1995) (71)
- Cytochrome P450 arachidonic acid epoxygenase: stereochemical characterization of epoxyeicosatrienoic acids. (1991) (71)
- The metabolism of benzo(alpha)pyrene in isolated rat liver cells. (1975) (70)
- Novel glutathione conjugates formed from epoxyeicosatrienoic acids (EETs). (1985) (69)
- Differences in the mechanism of NADPH- and cumene hydroperoxide-supported reactions of cytochrome P-450. (1980) (68)
- Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney. (1991) (67)
- Recombinant cytochrome P450 2D18 metabolism of dopamine and arachidonic acid. (2000) (67)
- Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid (2001) (66)
- The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis. (2009) (65)
- Arachidonic acid epoxygenase (1990) (65)
- Synthesis of arachidonic acid metabolites produced by purified kidney cortex microsomal cytochrome P-450 (1983) (63)
- Microsomal cytochrome P450 and eicosanoid metabolism (2002) (63)
- Arachidonic acid epoxidation: epoxyeicosatrienoic acids are endogenous constituents of rat liver. (1984) (61)
- Cytochrome P450 metabolites of arachidonic acid are potent inhibitors of vasopressin action on rabbit cortical collecting duct. (1989) (61)
- Role of cytochrome P450 epoxygenase in regulating renal membrane transport and hypertension (2013) (60)
- Overexpression of C-terminal Src Kinase Blocks 14,15-Epoxyeicosatrienoic Acid-induced Tyrosine Phosphorylation and Mitogenesis* (2000) (59)
- Synthesis of epoxyeicosatrienoic acids and heteroatom analogs. (1990) (59)
- Epoxyeicosatrienoic acid analogue lowers blood pressure through vasodilation and sodium channel inhibition. (2014) (59)
- Molecular, enzymatic, and regulatory characterization of rat kidney cytochromes P450 4A2 and 4A3. (1998) (58)
- Epoxygenase products of arachidonic acid are endogenous constituents of the hypothalamus involved in D2 receptor-mediated, dopamine-induced release of somatostatin. (1990) (58)
- Involvement of eicosanoids in release of oxytocin and vasopressin from the neural lobe of the rat pituitary. (1985) (56)
- Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase. (2013) (56)
- The Cyp2c44 Epoxygenase Regulates Epithelial Sodium Channel Activity and the Blood Pressure Responses to Increased Dietary Salt* (2013) (55)
- 5,6-Epoxyeicosatrienoic acid mobilizes Ca2+ in anterior pituitary cells. (1986) (53)
- Effects of newly reported arachidonic acid metabolites on microsomal Ca++ binding, uptake and release. (1983) (53)
- Development of Epoxyeicosatrienoic Acid Analogs with in Vivo Anti-Hypertensive Actions (2010) (52)
- Association of a CYP4A11 variant and blood pressure in black men. (2008) (51)
- Effect of phenobarbital and naphthalene on some of the components of the electron transport system and the hydroxylating activity of house fly microsomes. (1973) (50)
- Arachidonic acid epoxygenase: detection of epoxyeicosatrienoic acids in human urine. (1987) (50)
- Arachidonate epoxygenase: identification of epoxyeicosatrienoic acids in rabbit kidney. (1987) (50)
- PPARα activation can help prevent and treat non-small cell lung cancer. (2014) (49)
- 7-HETE, 10-HETE, and 13-HETE are major products of NADPH-dependent arachidonic acid metabolism in rat liver microsomes: analysis of their stereochemistry, and the stereochemistry of their acid-catalyzed rearrangement. (1995) (48)
- Novel hypothalamic arachidonate products stimulate somatostatin release from the median eminence. (1983) (48)
- Cytochrome P450 and the Metabolism of Arachidonic Acid and Oxygenated Eicosanoids (1995) (46)
- The mechanistic plurality of cytochrome P-450 and its biological ramifications. (1984) (46)
- Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy. (2015) (45)
- Characterization of the CYP4A11 gene, a second CYP4A gene in humans. (2003) (45)
- Resolution of epoxyeicosatrienoate enantiomers by chiral phase chromatography. (1989) (45)
- Influence of a fibric acid type of hypolipidemic agent on the oxidative metabolism of arachidonic acid by liver microsomal cytochrome P-450. (1985) (44)
- Structural determinants of active site binding affinity and metabolism by cytochrome P450 BM-3. (2001) (44)
- Role of cytochrome P-450 epoxygenase metabolites in EGF signaling in renal proximal tubule. (1995) (42)
- The existence of a benzo(a)pyrene-3,6-quinone reductase in rat liver microsomal fractions. (1978) (41)
- Renal microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid. (1988) (41)
- Cytochrome P-450 and drug metabolism in Trypanosoma cruzi: effects of phenobarbital. (1976) (38)
- Arachidonic acid monooxygenase: Genetic and biochemical approaches to physiological/pathophysiological relevance. (2015) (37)
- Palladium mediated allylic mitsunobu displacement: stereocontrolled synthesis of hepoxilin A3 and trioxilin A3 methyl esters (1992) (37)
- A novel pool of rat liver inositol and ethanolamine phospholipids contains epoxyeicosatrienoic acids (EETs). (1987) (37)
- Chiral α,β-Dialkoxy- and α-Alkoxy-β-aminostannanes: Preparation and Copper-Mediated Cross-Coupling (2003) (37)
- Absolute configuration of epoxyeicosatrienoic acids (EETs) formed during catalytic oxygenation of arachidonic acid by purified rat liver microsomal cytochrome P-450 (1984) (37)
- Epoxyeicosatrienoic Acids Activate Transglutaminases in Situ and Induce Cornification of Epidermal Keratinocytes* (2003) (36)
- Cyp2c44 Epoxygenase Is Essential for Preventing the Renal Sodium Absorption During Increasing Dietary Potassium Intake (2012) (36)
- Biochemical characterization of rat P450 2C11 fused to rat or bacterial NADPH-P450 reductase domains. (2000) (35)
- Cytochrome P-450-linked activation of 3-hydroxybenzo(a)pyrene (1975) (35)
- Dimethylthiocarbamate (DMTC): an alcohol protecting group. (2003) (34)
- The Role of Arachidonic Acid and Its Metabolites in the Release of Neuropeptides a (1989) (34)
- Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans (2017) (33)
- Biochemical and molecular characteristics of the cytochrome P450 arachidonic acid monooxygenase. (2000) (31)
- Characterization of a rat lung microsomal fraction obtained by sepharose 2B ultrafiltration. (1975) (31)
- Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases (2007) (31)
- Epoxyeicosatrienoic Acids (EETs) Regulate Epithelial Sodium Channel Activity by Extracellular Signal-regulated Kinase 1/2 (ERK1/2)-mediated Phosphorylation* (2013) (31)
- Hydrogen peroxide-supported oxidation of benzo [a]pyrene by rat liver microsomal fractions. (1981) (30)
- Mitogenic Activity and Signaling Mechanism of 2-(14,15- Epoxyeicosatrienoyl)Glycerol, a Novel Cytochrome P450 Arachidonate Metabolite (2007) (30)
- Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase. (2006) (30)
- Evidence that cytochrome P450 CYP2B19 is the major source of epoxyeicosatrienoic acids in mouse skin. (2005) (30)
- NADPH-dependent microsomal metabolism of 14,15-epoxyeicosatrienoic acid to diepoxides and epoxyalcohols. (1988) (30)
- High-fat diet-induced obesity and insulin resistance in CYP4a14-/- mice is mediated by 20-HETE. (2018) (30)
- 14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) Surrogates: Carboxylate Modifications (2014) (29)
- Total synthesis of the cytochrome P-450 epoxygenase metabolites 5(R),6(S)-, 5(S),6(R)-, and 14(R),15(S)-epoxyeicosatrienoic acid (EET) and hydration products 5(R),6(R)- and 14(R),15(R)-dihydroxyeicosatrienoic acid (DHET) (1985) (28)
- PPARα Ligands as Antitumorigenic and Antiangiogenic Agents (2008) (28)
- The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production. (2018) (28)
- Insulin second messengers : synthesis of 6-O-(2-amino-2-deoxy-α-D-glucopyranosyl)-D-chiro-inositol-1-phosphate (1993) (27)
- 20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension. (2013) (27)
- Arachidonate epoxygenase: Total synthesis of both enantiomers of 8,9- and 11,12-epoxyricosatrienoic acid (1986) (27)
- 20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice (2016) (26)
- Hemoproteins in Trypanosoma cruzi with emphasis on microsomal pigments (1976) (26)
- Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension. (2015) (26)
- Cytochrome P450 and the Metabolism and Bioactivation of Arachidonic Acid and Eicosanoids (2005) (25)
- Arachidonate epoxygenase: inhibitors and metabolite analogues (1985) (25)
- Epoxygenation of arachidonic acid by rat anterior pituitary microsomal fractions (1984) (25)
- Increased Renal Proximal Convoluted Tubule Transport Contributes to Hypertension in Cyp4a14 Knockout Mice (2009) (24)
- Effects of epoxyicosatrienoic acids on ion transport in the rabbit cortical collecting tubule (1984) (24)
- Stereospecific synthesis of EET metabolites via Suzuki-Miyaura coupling (2001) (24)
- The metabolic activation of benzo(a)pyrene and 9‐hydroxybenzo (a) pyrene by liver microsomal fractions (1979) (23)
- Enantiospecific total synthesis of 8- and 12-hydroxyeicosatetraenoic acid (1986) (23)
- Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria. (2017) (23)
- The microsomal metabolism of benzo(a) pyrene phenols. (1978) (22)
- Some spectral properties of cytochrome P-450 from microsomes isolated from control, phenobarbital- and naphthalene-treated houseflies. (1973) (22)
- CHIRAL ACETALS : STEREOCONTROLLED SYNTHESES OF 16-,17-, AND 18-HYDROXYEICOSATETRAENOIC ACIDS, CYTOCHROME P-450 ARACHIDONATE METABOLITES (1996) (22)
- Microsomal cytochrome P450 and eicosanoid metabolism. (2002) (20)
- Preparation of N-tBoc L-glutathione dimethyl and di-tert-butyl esters: versatile synthetic building blocks. (2007) (20)
- Eicosanoid biosynthesis : Differential inhibition of cytochrome P450 epoxygenase and ω-hydroxylase (1997) (20)
- Role of epoxyeicosatrienoic acids (EETs) in mediation of dopamine's effects in the kidney. (2013) (19)
- Cyp2c44 epoxygenase in the collecting duct is essential for the high K+ intake-induced antihypertensive effect. (2014) (19)
- The CYP P450 arachidonate monooxygenases: enzymatic relays for the control of kidney function and blood pressure. (2003) (19)
- Nutritionally triggered alterations in the regiospecificity of arachidonic acid oxygenation by rat liver microsomal cytochrome P450. (1989) (19)
- The renal antihypertensive endocrine function: its relation to cytochrome P-450. (1989) (19)
- Modulation of arteriolar blood flow by inhibitors of arachidonic acid oxidation after thermal injury: possible role for a novel class of vasodilator metabolites. (1988) (19)
- Concise syntheses of L-α-phosphatidyl-D-myo-inositol 3-phosphate (3- PIP), 5-phosphate (5-PIP), and 3,5-bisphosphate (3,5-PIP2) (2000) (18)
- Chiral cyclopropanes: Asymmetric synthesis of constanolactones A and B (2002) (18)
- Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites. (2006) (17)
- Total synthesis of the ethanol inducible, proinflammatory autacoid 3(S)-hydroxy-leukotriene B4 (3-OH-LTB4) and analogues (1994) (17)
- Enantiospecific synthesis of methyl 11,12- and 14,15-epoxyeicosatrienoate (1984) (16)
- Evaluation of cytochrome P450 4 family as mediator of phospholipase D activation in aortic vascular smooth muscle cells. (2005) (16)
- MULTIPLE FORMS OF HOUSEFLY CYTOCHROME P-450 (1977) (15)
- 15 – The Role of Cytochrome P-450 and the Microsomal Electron Transport System: The Oxidative Metabolism of Benzo[a]pyrene (1978) (14)
- Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria. (2017) (14)
- Resolution of dihydroxyeicosanoates and of dihydroxyeicosatrienoates by chiral phase chromatography. (1992) (14)
- Transformation of 15-hete to 14,15-dihydroxyeicosatrienoic acid and 11,14,15- and 13,14,15-trihydroxyeicosatrienoic acid (1983) (14)
- Spectral and catalytic properties of cytochrome P-450 from a diazinon-resistant housefly strain. (1974) (13)
- Cyp2c44 Gene Disruption Exacerbated Pulmonary Hypertension and Heart Failure in Female but Not Male Mice (2016) (13)
- Metabolism of benzo[a]pyrene‐3,6‐quinone by isolated hepatocytes (1980) (13)
- Preparation of l-α-phosphatidyl-d-myo-inositol 3-phosphate (3-PIP) and 3,5-bisphosphate (3,5-PIP2) (2000) (13)
- The metabolism of benzo[a]pyrene phenols by rat liver microsomal fractions. (1981) (13)
- A synthesis of l-α-phosphatidyl-d-myo-inositol 4,5-bisphosphate (4,5-PIP2) and glyceryl lipid analogs (1999) (13)
- Cardiovascular and renal actions of cytochrome P-450 metabolites of arachidonic acid. (1989) (12)
- Solubilization and partial purification of cytochrome P-450 from rat lung microsomes. (1975) (12)
- Metabolism of 12(R)-hydroxyeicosatetraenoic acid by rat liver microsomes. (1992) (11)
- Synthesis of 14(R),15(S)- and 14(s),15(S)-dihydroxy-5,8-z-10,12-E - eicosatetraenoic acid (1983) (10)
- Intracellular second messengers synthesis of L-α-phosphatidyl-D-myo-inositol 3,4-bisphosphate and analogs (1997) (10)
- A practical, stereospecific route to 18-, 19-, and 20-hydroxyeicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acids (18-, 19-, and 20-HETEs) (2004) (10)
- Enantiospecific synthesis of 17- and 18-hydroxyeicosatetraenoic acids, cytochrome P450 arachidonate metabolites (1992) (10)
- Hepoxilins B3: Synthesis of all four stereoisomers and a glutathione adduct (1994) (10)
- The arachidonic acid monooxygenase: from biochemical curiosity to physiological/pathophysiological significance (2018) (10)
- Sequential solubilization of microsomal mixed function oxidases. (1973) (9)
- Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy: counterregulation of hyperfiltration. (1993) (9)
- 5- and 8-HETE production by rat hepatic microsomal cytochrome P-450 (1984) (9)
- Total synthesis of 5(S),12(S)- and 5(S),12(R)-dihydroxyeicosa-6(Z),8(E),14(Z)-trienoic acids, metabolites of leukotriene B4 (1989) (9)
- Cyp2c44 gene disruption is associated with increased hematopoietic stem cells: implication in chronic hypoxia-induced pulmonary hypertension. (2017) (9)
- Erratum: Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria (Cell Chemical Biology (2017) 24(10) (1259–1275.e6) (S2451945617302830)(10.1016/j.chembiol.2017.08.009)) (2017) (8)
- Eicosanoid Metabolism and Bioactivation by Microsomal Cytochrome P450 (1996) (8)
- Efficient total synthesis of 5-oxo-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid (5-oxo-ETE), a potent proinflammatory autacoid (2001) (7)
- Cytochrome P-450 Epoxygenase Dependent Formation of Novel Endogenous Epoxyeicosatrienoyl-Phospholipids (1993) (7)
- Mitogenic Activity and Signaling Mechanism of 2-(14,15-Epoxyeicosatrienoyl)Glycerol, a Novel Cytochrome P450 Arachidonate Metabolite (2007) (6)
- Polycyclic hydrocarbon metabolism: a plethora of phenomena. (1980) (6)
- Involvement of arachidonic acid metabolites in the control of hypothalamic-pituitary function. (1985) (6)
- Recombinant Cytochrome P 450 2 D 18 Metabolism of Dopamine and Arachidonic Acid 1 (2000) (5)
- ReviewArticle PPARα Ligands as Antitumorigenic and Antiangiogenic Agents (2008) (5)
- Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z), 11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity. (2003) (5)
- The effect of DDT treatment on the levels of DDT-dehydrochlorinase in Musca domestica. (1973) (4)
- Erratum: Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome P450 arachidonate metabolite (Molecular and Cellular Biology (2007) 27, 8, (3023-3034)) (2007) (4)
- Kidney Cyp 2 c 44 Epoxygenase Is Essential for Preventing the Renal Sodium Absorption During Increasing Dietary Potassium Intake (2012) (4)
- Total synthesis of 5(S),20- and 15(S),20-dihydroxyeicosatetraenoic acid and 5(S),6(R)-epoxy-20-hydroxy- and 14(R),15(S)-epoxy-20-hydroxyeicosatreinoic acid (1987) (3)
- vic-Diol chirons: Enantiospecific synthesis of 11,12- and 14,15-dihydroxyeicosatrienoic acids (1994) (3)
- Chiral α,β‐Dialkoxy‐ and α‐Alkoxy‐β‐aminostannanes: Preparation and Copper‐Mediated Cross‐Coupling. (2004) (3)
- Biochemical Considerations of the Enzymology Associated with Quinone and Tetrol Formation During Benzo(A)Pyrene Metabolism (1980) (3)
- 20‐SOLA, a Novel Water Soluble 20‐HETE Antagonist, Reduces Blood Pressure Through Regulation of Vascular ACE Expression via an IKK Dependent Pathway (2015) (3)
- Correction to 14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) Surrogates: Carboxylate Modifications (2014) (2)
- Insulin Second Messengers: Synthesis of 6‐O‐(2‐Amino‐2‐deoxy‐α‐D‐ glucopyranosyl)‐D‐chiro‐inositol‐1‐phosphate. (1994) (2)
- Cytochrome P450 promotes breast cancer cell proliferation. (2006) (2)
- DDT-dehydrochlorinase IV.—Further evidence on the lipoprotein nature of the enzyme (1975) (2)
- THE METABOLISM OF POLYCYCLIC HYDROCARBONS AND ITS RELATIONSHIP TO CHEMICAL CARCINOGENESIS (1976) (2)
- Metabolic activation of benzo[a]pyrene and 9-hydorxybenzo[a]pyrene by tissue fractions from rat liver and lung [proceedings]. (1979) (2)
- Cyp 2 c 44 gene disruption is associated with increased hematopoietic stem cells : implication in chronic hypoxia-induced pulmonary hypertension (2017) (2)
- A Synthesis of L‐α‐Phosphatidyl‐D‐myo‐inositol 4,5‐Bisphosphate (4,5‐PIP2) and Glyceryl Lipid Analogues. (2000) (2)
- Arachidonate Epoxygenase: Total Synthesis of Both Enantiomers of 8,9and 11,12-Epoxyeicosatrienoic Acid. (1987) (2)
- THE METABOLISM OF 3- AND 9-HYDROXYBENZO(a)PYRENE BY RAT LIVER MICROSOMAL FRACTIONS (1980) (1)
- Abstract 2689: Breast cancer inhibition by a novel and potent biguanide, N1-hexyl-N5-benzyl-biguanide (2014) (1)
- Convenient syntheses of [20,20,20-H(3)]-arachidonic acid and [20,20-H(2)]-20-hydroxyeicosatetraenoic acid. (2006) (1)
- Molecular characterization of a renal cytochrome p450 epoxygenase responsive to animal sodium chloride loading (1992) (1)
- Integrative Physiology 20-HETE Signals Through G-Protein–Coupled Receptor GPR75 (G q ) to Affect Vascular Function and Trigger Hypertension (2017) (1)
- Enantiospecific Total Synthesis of 8- and 12-Hydroxyeicosatetraenoic Acid. (1987) (1)
- The cytochrome P450-dependent metabolism of arachidonic acid (1984) (1)
- Abstract 047: 20-SOLA, A Novel Water-soluble 20-HETE Antagonist, Elicits Natriuresis And Abrogates Hypertension In Cyp4a14 Knockout Mice. (2014) (1)
- TRANSFORMATION OF 15-HETE TO 14,15-DIHYDROXYEICOSATRIENOIC ACID AND 11,14,15- AND 13,14,15-TRIHYDROXYEICOSATRIENOIC ACIDS (1984) (0)
- Abstract 355: Mineralocorticoid Receptor Activation Alters Epoxyeicosatrienoic Acid Production In Vivo (2013) (0)
- Tumor and Stem Cell Biology PPAR a ActivationCanHelpPrevent andTreatNon – SmallCell Lung Cancer (2014) (0)
- Functional expression of recombinant adenovirus carrying bacterial cP450 epoxygenase in rat hippocampal astrocytes (2000) (0)
- Regulation of CYP4A genes by peroxisome proliferator activated receptors (1997) (0)
- Cytochrome P-450-linked activation of 3-hydroxybenzo(alpha)pyrene. (1975) (0)
- Abstract 340: Deletion of Cyp2c44-epoxygenase in the Collecting Duct Causes the Hypertension in Mice on a High K Diet (2012) (0)
- Abstract 342: Vascular Endothelial Ace Deletion Or AT1R Blockade Reduces Blood Pressure But Does Not Prevent Vascular Remodeling In Models Of 20-HETE-Dependent Hypertension (2014) (0)
- Content Vol. 113, 2009 (2009) (0)
- Abstract 064: 20-HETE Contributes to Vasoconstriction of Renal Microvessels and Sodium Retention in Cyp4a14-/- Mice, a Model of 20-HETE Dependent Hypertension (2015) (0)
- Abstract 534: Cytochrome P450 epoxygenase regulates Na transport in aldosterone-sensitive distal nephron: a lesson learns from Cyp2c44 knockout mice (2014) (0)
- Total Synthesis of the Ethanol-Inducible, Proinflammatory Autacoid 3(S) -Hydroxy-Leukotriene B4 (3-OH-LTB4) and Analogues. (1994) (0)
- The arachidonic acid epoxygenase: A functional role for cytochrome P450 in the biosynthesis of novel lipid derived mediators (1992) (0)
- Practical, Asymmetric Synthesis of 16-Hydroxyeicosa-5(Z),8(Z),11(Z), 14(Z)-tetraenoic Acid (16-HETE), an Endogenous Inhibitor of Neutrophil Activity. (2004) (0)
- Biochemical and functional properties of the P450 arachidonic acid monooxygenase (1999) (0)
- Liver microsomal cytochrome P-450andtheoxidative metabolism ofarachidonic acid (microsomal electron transport/oxygenase/fatty acid metabolism) (1981) (0)
- 603 – RESOLUTION AND RECONSTITUTE ON OF RAT LUNG ARYL HYDROCARBON MONOOXYGENASE (1977) (0)
- Stereospecific Synthesis of EET Metabolites via Suzuki—Miyaura Coupling. (2010) (0)
- 22nd Meeting of the ESM, August 2002 (2001) (0)
- cP450 Epoxygenase exerts potent cytoprotective effects by a dual mechanism in renal epithelial cells (1999) (0)
- Chiral alpha,beta-dialkoxy- and alpha-alkoxy-beta-aminostannanes: preparation and copper-mediated cross-coupling. (2003) (0)
- produced by a cytochrome P450 monooxygenase Intestinal vasodilation by epoxyeicosatrienoic acids: arachidonic acid metabolites (2011) (0)
- Author / Subject Vol. 113, 2009 (2009) (0)
- Abstract 263: 20-hete-induced Vascular Remodeling in Models Of Androgen-dependent and Independent Hypertension (2012) (0)
- vic‐Diol Chirons: Enantiospecific Synthesis of 11,12‐ and 14,15‐ Dihydroxyeicosatrienoic Acids. (1995) (0)
- Effect of cytochrome P-450 induction and inhibition on the antihypertensive function of the kidney. (1987) (0)
- Role of Cyp-epoxygenase in regulating renal membrane transport and hypertension (2014) (0)
- of Arachidonic Acid Inhibits Apoptosis Cytochrome P 450 Epoxygenase Metabolism (2001) (0)
- Chiral Cyclopropanes: Asymmetric Synthesis of Constanolactones A and B. (2002) (0)
- Chiral Acetals: Stereocontrolled Syntheses of 16‐, 17‐, and 18‐ Hydroxyeicosatetraenoic Acids, Cytochrome P‐450 Arachidonate Metabolites. (2010) (0)
- Does Malfunction of Arachidonic Acid Epoxygenase Explain Salt-Sensitive Hypertension?: Salt-Sensitive Hypertension Is Associated with Dysfunctional Cyp4a10 Gene and Kidney Epithelial Sodium Channel. J Clin Invest 116: 1696-1702, 2006. (2006) (0)
- Total Synthesis of 5(S),20- and 15(S),20-Dihydroxyeicosatetraenoic Acid and 5(S),6(R)-Epoxy-20-hydroxy- and 14(R),15(S)-Epoxy-20-hydroxyeicosatrienoic Acid. (1987) (0)
- Abstract 015: Increased 20-HETE Levels Contribute to Impaired Glucose Metabolism and Type 2 Diabetes in Cyp4a14 Knockout Mice Fed on High Fat Diet. (2015) (0)
- Abstract 44: Hexyl-benzyl-biguanide (HBB) potently and selectively inhibits CYP3A4 epoxygenase activity and inhibits EET stabilization of mitochondrial respiration in ER+HER2- breast cancer cells, inducing glycolysis and pyruvate biosynthesis (2016) (0)
- Abstract 159: Inhibition of Ace Does Not Prevent 20-hete-mediated Vascular Injury in Cyp4a12tg Mice (2013) (0)
- Concise Syntheses of L‐α‐phosphatidyl‐D‐myo‐inositol 3‐Phosphate (3‐PIP), 5‐Phosphate (5‐PIP), and 3,5‐Bisphosphate (3,5‐PIP2). (2000) (0)
- Efficient Total Synthesis of 5-Oxo-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic Acid (5-Oxo-ETE), a Potent Proinflammatory Autacoid. (2002) (0)
- Induction of Renal Arachidonate Cytochrome P-450 Epoxygenase After Uninephrectomy: Counterregulation of rf1 (1993) (0)
- 145 – THE METABOLISM OF 3,4-BENZPYRENE IN ISOLATED RAT LIVER CELLS (1977) (0)
- Abstract 202: Activation of Cyp4a12-20-HETE Synthase Increases Blood Pressure and Promotes Vascular Hypertrophy and Cardiac Dysfunction (2013) (0)
- Preparation of L-alpha-phosphatidyl-D-myo-inositol 3-phosphate (3-PIP) and 3,5-bisphosphate (3,5-PIP2). (2000) (0)
- Eicosanoid Biosynthesis: Differential Inhibition of Cytochrome P450 Epoxygenase and ω-Hydroxylase. (2010) (0)
- SYNTHESIS OF 14(R),15(S)- AND 14(S),15(S)-DIHYDROXY-5,8-Z-10,12-E-EICOSATETRAENOIC ACID (1984) (0)
- 20‐HETE INDUCES REMODELING OF RENAL RESISTANCE ARTERIES INDEPENDENT OF BLOOD PRESSURE ELEVATION IN ANDROGEN‐INDUCED HYPERTENSION (2013) (0)
- Erratum to “Characterization of the CYP4A11 gene, a second CYP4A gene in humans” [Arch. Biochem. Biophys. 409 (2003) 221–227] (2003) (0)
- Cytochrome P-450 Arachidonic Acid Epoxygenase (2001) (0)
- Palladium-Mediated Allylic Mitsunobu Displacement: Stereocontrolled Synthesis of Hepoxilin A3 and Trioxilin A3 Methyl Esters. (1992) (0)
- Abstract 3568: CYP3A4 epoxygenase activity mediates ER+ mammary tumor growth and angiogenesis, in part, through EET biosynthesis and is inhibited by biguanides (2015) (0)
- Abstract 942: CYP3A4 epoxygenase mediates hypoxia-induced biosynthesis of epoxyeicosatrienoic acids (±)-11,12- and (±)-14,15-EET in breast cancer cells (2012) (0)
- Hepoxilins B3: Synthesis of All Four Stereoisomers and a Glutathione Adduct. (1994) (0)
- Abstract 357: CYP3A4 Activates Stat3 in ER + breast cancer (2011) (0)
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What Schools Are Affiliated With Jorge H. Capdevila?
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