Josef Martin Pfeilschifter

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#1410

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#1746

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#148

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Josef Martin Pfeilschifter

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#4483

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#7017

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#2794

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Josef Martin Pfeilschifter's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Cyclooxygenase‐independent actions of cyclooxygenase inhibitors (2001) (768)
Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repair. (2000) (541)
Physiology and pathophysiology of sphingolipid metabolism and signaling. (2000) (440)
Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors* (2009) (420)
A transgenic mouse model of inducible macrophage depletion: effects of diphtheria toxin-driven lysozyme M-specific cell lineage ablation on wound inflammatory, angiogenic, and contractive processes. (2009) (344)
Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repair. (2000) (312)
IL-1 family nomenclature (2010) (302)
Signaling by the Matrix Proteoglycan Decorin Controls Inflammation and Cancer Through PDCD4 and MicroRNA-21 (2011) (284)
Nitric oxide triggers enhanced induction of vascular endothelial growth factor expression in cultured keratinocytes (HaCaT) and during cutaneous wound repair (1999) (239)
The function of nitric oxide in wound repair: inhibition of inducible nitric oxide-synthase severely impairs wound reepithelialization. (1999) (228)
Anti-inflammatory properties of pro-inflammatory interferon-gamma. (2003) (220)
Amplification of IL-1β-Induced Matrix Metalloproteinase-9 Expression by Superoxide in Rat Glomerular Mesangial Cells Is Mediated by Increased Activities of NF-κB and Activating Protein-1 and Involves Activation of the Mitogen-Activated Protein Kinase Pathways1 (2000) (217)
Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR. (2008) (216)
Atrial natriuretic peptide inhibits renin release from juxtaglomerular cells by a cGMP-mediated process. (1986) (211)
Cytokine-stimulated secretion of group II phospholipase A2 by rat mesangial cells. Its contribution to arachidonic acid release and prostaglandin synthesis by cultured rat glomerular cells. (1993) (205)
Inducible NO synthase: role in cellular signalling. (1999) (193)
Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2. (2007) (193)
Nitric oxide drives skin repair: novel functions of an established mediator. (2002) (190)
Sphingosine 1-Phosphate Cross-activates the Smad Signaling Cascade and Mimics Transforming Growth Factor-β-induced Cell Responses* (2004) (188)
Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase. (1996) (186)
Interleukin 1 and tumor necrosis factor synergistically stimulate prostaglandin synthesis and phospholipase A2 release from rat renal mesangial cells. (1989) (185)
Translational Control of Inducible Nitric Oxide Synthase by IL-13 and Arginine Availability in Inflammatory Macrophages 1 (2003) (184)
Posttranslational Modification of the AU-Rich Element Binding Protein HuR by Protein Kinase Cδ Elicits Angiotensin II-Induced Stabilization and Nuclear Export of Cyclooxygenase 2 mRNA (2008) (184)
Nitric Oxide Increases the Decay of Matrix Metalloproteinase 9 mRNA by Inhibiting the Expression of mRNA-Stabilizing Factor HuR (2003) (176)
Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection (2008) (174)
Arginase 1 overexpression in psoriasis: limitation of inducible nitric oxide synthase activity as a molecular mechanism for keratinocyte hyperproliferation. (2002) (171)
Modulation of mRNA stability as a novel therapeutic approach. (2007) (170)
The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis. (2010) (169)
Human Urotensin II Is a Novel Activator of NADPH Oxidase in Human Pulmonary Artery Smooth Muscle Cells (2005) (165)
Expressional Regulation of Angiopoietin-1 and -2 and the Tie-1 and -2 Receptor Tyrosine Kinases during Cutaneous Wound Healing: A Comparative Study of Normal and Impaired Repair (2001) (158)
Two distinct signaling pathways trigger the expression of inducible nitric oxide synthase in rat renal mesangial cells. (1994) (157)
Severely impaired insulin signaling in chronic wounds of diabetic ob/ob mice: a potential role of tumor necrosis factor-alpha. (2006) (157)
Transforming growth factor β2 inhibits interleukin 1β- and tumour necrosis factor α-induction of nitric oxide synthase in rat renal mesangial cells (1991) (153)
Molecular mechanisms of dexamethasone inhibition of nitric oxide synthase expression in interleukin 1 beta-stimulated mesangial cells: evidence for the involvement of transcriptional and posttranscriptional regulation. (1996) (152)
Nitric oxide modulates expression of matrix metalloproteinase-9 in rat mesangial cells. (2000) (150)
Expression and Release of IL-18 Binding Protein in Response to IFN-γ1 (2001) (149)
SphK1 Regulates Proinflammatory Responses Associated with Endotoxin and Polymicrobial Sepsis (2010) (146)
Tumor necrosis factor-alpha and lipopolysaccharide induce apoptotic cell death in bovine glomerular endothelial cells. (1999) (146)
Molecular mechanisms of inducible nitric oxide synthase gene expression by IL-1beta and cAMP in rat mesangial cells. (1998) (145)
Dual Effect of Ceramide on Human Endothelial Cells: Induction of Oxidative Stress and Transcriptional Upregulation of Endothelial Nitric Oxide Synthase (2002) (142)
Regulation of gene expression by nitric oxide (2001) (141)
Systemic anti-TNFalpha treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages. (2007) (141)
Interleukin 1 and tumor necrosis factor stimulate cGMP formation in rat renal mesangial cells (1990) (140)
Nitric Oxide Donors Induce Stress Signaling via Ceramide Formation in Rat Renal Mesangial Cells* (1999) (136)
Molecular cloning of the rat inducible nitric oxide synthase gene promoter. (1996) (134)
The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia. (2009) (132)
Ceramide binds to the CaLB domain of cytosolic phospholipase A2 and facilitates its membrane docking and arachidonic acid release (2001) (130)
Mechanisms of suppression of inducible nitric-oxide synthase (iNOS) expression in interferon (IFN)-gamma-stimulated RAW 264.7 cells by dexamethasone. Evidence for glucocorticoid-induced degradation of iNOS protein by calpain as a key step in post-transcriptional regulation. (1997) (127)
Nitric oxide and superoxide induced p53 and Bax accumulation during mesangial cell apoptosis. (1997) (122)
Platelet-derived growth factor and angiotensin II stimulate the mitogen-activated protein kinase cascade in renal mesangial cells: comparison of hypertrophic and hyperplastic agonists. (1995) (121)
Selective ceramide binding to protein kinase C-alpha and -delta isoenzymes in renal mesangial cells. (1998) (120)
Wound Healing in Mice with High-Fat Diet- or ob Gene-Induced Diabetes-Obesity Syndromes: A Comparative Study (2011) (118)
Interleukin 1β and tumour necrosis factor α induce a macrophage‐type of nitric oxide synthase in rat renal mesangial cells (1992) (116)
Glucocorticoid-mediated suppression of cytokine-induced matrix metalloproteinase-9 expression in rat mesangial cells: involvement of nuclear factor-kappaB and Ets transcription factors. (2002) (115)
Induction of inducible nitric oxide synthase and its corresponding tetrahydrobiopterin-cofactor-synthesizing enzyme GTP-cyclohydrolase I during cutaneous wound repair. (1998) (112)
CXCL10 promotes liver fibrosis by prevention of NK cell mediated hepatic stellate cell inactivation. (2010) (111)
The Interleukin-22/STAT3 Pathway Potentiates Expression of Inducible Nitric-oxide Synthase in Human Colon Carcinoma Cells* (2007) (111)
The balance between nitric oxide and superoxide determines apoptotic and necrotic death of rat mesangial cells. (1997) (110)
Stimulation by extracellular ATP and UTP of the mitogen‐activated protein kinase cascade and proliferation of rat renal mesangial cells (1994) (110)
Leptin and wound inflammation in diabetic ob/ob mice: differential regulation of neutrophil and macrophage influx and a potential role for the scab as a sink for inflammatory cells and mediators. (2003) (109)
Biglycan-triggered TLR-2- and TLR-4-signaling exacerbates the pathophysiology of ischemic acute kidney injury. (2014) (109)
Pertussis toxin abolishes angiotensin II-induced phosphoinositide hydrolysis and prostaglandin synthesis in rat renal mesangial cells. (1986) (108)
New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets. (2008) (107)
Reduced nitric oxide in sinus epithelium of patients with radiologic maxillary sinusitis and sepsis. (2003) (106)
Nitric oxide donors induce apoptosis in glomerular mesangial cells, epithelial cells and endothelial cells. (1996) (103)
Cross‐talk between transmembrane signalling systems: a prerequisite for the delicate regulation of glomerular haemodynamics by mesangial cells (1989) (99)
The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line MCF7. (2005) (99)
Tumoural CXCL16 expression is a novel prognostic marker of longer survival times in renal cell cancer patients. (2009) (98)
Interleukin-1β, tumor necrosis factor and forskolin stimulate the synthesis and secretion of group II phospholipase A2 in rat mesangial cells (1991) (97)
Interferon-gamma mediates gene expression of IL-18 binding protein in nonleukocytic cells. (2000) (96)
A novel keratinocyte mitogen: regulation of leptin and its functional receptor in skin repair. (2001) (96)
Cross-talk between secretory phospholipase A2 and cytosolic phospholipase A2 in rat renal mesangial cells. (1997) (95)
Selective inhibition of cyclooxygenase 2. (1994) (94)
Potentiation of Tumor Necrosis Factor α-induced Secreted Phospholipase A2 (sPLA2)-IIA Expression in Mesangial Cells by an Autocrine Loop Involving sPLA2 and Peroxisome Proliferator-activated Receptor α Activation* (2003) (93)
Prediction of Acute Renal Allograft Rejection by Urinary Monokine Induced by IFN-γ (MIG) (2005) (93)
Comparison of extracellular ATP and UTP signalling in rat renal mesangial cells. No indications for the involvement of separate purino- and pyrimidino-ceptors. (1990) (89)
ADAM10 is upregulated in melanoma metastasis compared with primary melanoma. (2010) (89)
Activation of protein kinase C subtypes alpha, gamma, delta, epsilon, zeta, and eta by tumor-promoting and nontumor-promoting agents. (1997) (88)
Protective properties of inhaled IL-22 in a model of ventilator-induced lung injury. (2011) (88)
Hypoxia induces macrophage inflammatory protein‐2 (MIP‐2) gene expression in murine macrophages via NF‐κB: the prominent role of p42/ p44 and PI3 kinase pathways (2004) (87)
MicroRNA-145 targets the metalloprotease ADAM17 and is suppressed in renal cell carcinoma patients. (2013) (87)
Tandem Phosphorylation of Serines 221 and 318 by Protein Kinase Cδ Coordinates mRNA Binding and Nucleocytoplasmic Shuttling of HuR (2010) (87)
Nitric oxide: an inflammatory mediator of glomerular mesangial cells. (1993) (87)
Cyclosporin A augments angiotensin II-stimulated rise in intracellular free calcium in vascular smooth muscle cells. (1987) (85)
Cyclooxygenase-1-coupled prostaglandin biosynthesis constitutes an essential prerequisite for skin repair. (2003) (83)
Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of rapamycin. (2007) (83)
Molecular Mechanisms of TGFβ Receptor-Triggered Signaling Cascades Rapidly Induced by the Calcineurin Inhibitors Cyclosporin A and FK5061 (2008) (82)
Identification of copper/zinc superoxide dismutase as a nitric oxide-regulated gene in human (HaCaT) keratinocytes: implications for keratinocyte proliferation. (2000) (82)
Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells. (2008) (81)
The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J2 ameliorates ischemic acute renal failure. (2004) (81)
Possible regulatory functions of protein kinase C-alpha and -epsilon isoenzymes in rat renal mesangial cells. Stimulation of prostaglandin synthesis and feedback inhibition of angiotensin II-stimulated phosphoinositide hydrolysis. (1991) (80)
ATP Potentiates Interleukin-1β-induced MMP-9 Expression in Mesangial Cells via Recruitment of the ELAV Protein HuR* (2003) (79)
New insights into the mechanism for clearance of apoptotic cells. (2000) (79)
Counterregulation of interleukin-18 mRNA and protein expression during cutaneous wound repair in mice. (1999) (79)
Decline in the expression of copper/zinc superoxide dismutase in the kidney of rats with endotoxic shock: Effects of the superoxide anion radical scavenger, tempol, on organ injury (1998) (78)
The Dipeptidyl Peptidase-4 Inhibitor Linagliptin Attenuates Inflammation and Accelerates Epithelialization in Wounds of Diabetic ob/ob Mice (2012) (78)
Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia. (2011) (77)
Amplification of nitric oxide synthase expression by nitric oxide in interleukin 1 beta-stimulated rat mesangial cells. (1995) (77)
CXCL16 is expressed in podocytes and acts as a scavenger receptor for oxidized low-density lipoprotein. (2009) (76)
Activation of phospholipase C and prostaglandin synthesis by [arginine]vasopressin in cultures. (1984) (75)
Cystathionine &ggr; Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis (2019) (75)
Imbalance in distribution of functional autologous regulatory T cells in rheumatoid arthritis (2007) (75)
Pyrrolidine dithiocarbamate differentially affects interleukin 1 beta- and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells. (1994) (75)
Expression and activity of arginase isoenzymes during normal and diabetes-impaired skin repair. (2003) (75)
Interleukin-18 bioactivity: a novel target for immunopharmacological anti-inflammatory intervention. (2004) (75)
Differential regulation of vascular endothelial growth factor and its receptor fms-like-tyrosine kinase is mediated by nitric oxide in rat renal mesangial cells. (1999) (74)
Large induction of the chemotactic cytokine RANTES during cutaneous wound repair: a regulatory role for nitric oxide in keratinocyte-derived RANTES expression. (2000) (74)
Coexpression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter 2 from a helper virus-free herpes simplex virus type 1 vector supports high-level, long-term biochemical and behavioral correction of a rat model of Parkinson's disease. (2004) (72)
Decorin deficiency in diabetic mice: aggravation of nephropathy due to overexpression of profibrotic factors, enhanced apoptosis and mononuclear cell infiltration. (2009) (72)
Glucocorticoids inhibit lipopolysaccharide‐induced up‐regulation of arginase in rat alveolar macrophages (2001) (71)
Role of protein kinase C in inhibition of renin release caused by vasoconstrictors. (1986) (71)
Downregulation of iNOS expression in rat mesangial cells by special extracts of Harpagophytum procumbens derives from harpagoside-dependent and independent effects. (2004) (71)
Sphingosine-1-phosphate: a Janus-faced mediator of fibrotic diseases. (2013) (71)
Biglycan, a Nitric Oxide-regulated Gene, Affects Adhesion, Growth, and Survival of Mesangial Cells* (2003) (70)
Expression of nitric oxide synthase in rat glomerular mesangial cells mediated by cyclic AMP (1994) (70)
The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells (2006) (70)
Prolactin upregulates sphingosine kinase-1 expression and activity in the human breast cancer cell line MCF7 and triggers enhanced proliferation and migration. (2007) (70)
Mesangial Cells Orchestrate Inflammation in the Renal Glomerulus (1994) (69)
Inhibition of Cytokine-induced Matrix Metalloproteinase 9 Expression by Peroxisome Proliferator-activated Receptor α Agonists Is Indirect and Due to a NO-mediated Reduction of mRNA Stability* (2002) (69)
Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression. (2009) (69)
Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury. (2019) (68)
Anti‐inflammatory effects of sevoflurane and mild hypothermia in endotoxemic rats (2007) (68)
Molecular mimicry rather than identity breaks T-cell tolerance in the CYP2D6 mouse model for human autoimmune hepatitis. (2013) (67)
Application of interleukin-22 mediates protection in experimental acetaminophen-induced acute liver injury. (2013) (67)
Lipids as targets for novel anti-inflammatory therapies. (2009) (67)
Interleukin-1 beta- and forskolin-induced synthesis and secretion of group II phospholipase A2 and prostaglandin E2 in rat mesangial cells is prevented by transforming growth factor-beta 2. (1992) (67)
Akt1 controls insulin-driven VEGF biosynthesis from keratinocytes: implications for normal and diabetes-impaired skin repair in mice. (2009) (67)
Interleukin‐1β and transforming growth factor‐β2 enhance cytosolic high‐molecular‐mass phospholipase A2 activity and induce prostaglandin E2 formation in rat mesangial cells (1992) (66)
Rapid and delayed p42/p44 mitogen-activated protein kinase activation by nitric oxide: the role of cyclic GMP and tyrosine phosphatase inhibition. (1998) (66)
Nitric oxide down‐regulates the expression of the catalytic NADPH oxidase subunit Nox1 in rat renal mesangial cells (2006) (65)
Wound inflammation in diabetic ob/ob mice: functional coupling of prostaglandin biosynthesis to cyclooxygenase-1 activity in diabetes-impaired wound healing. (2005) (65)
Interleukin-1β Induces Chronic Activation and de Novo Synthesis of Neutral Ceramidase in Renal Mesangial Cells* (2001) (65)
Quantitative Persulfide Site Identification (qPerS-SID) Reveals Protein Targets of H2S Releasing Donors in Mammalian Cells (2016) (64)
Dexamethasone differentially affects interleukin 1 beta- and cyclic AMP-induced nitric oxide synthase mRNA expression in renal mesangial cells. (1994) (64)
Inducible NO synthase and antibacterial host defence in times of Th17/Th22/T22 immunity (2011) (64)
A Novel Mode of Action of the Putative Sphingosine Kinase Inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) Thiazole (SKI II): Induction of Lysosomal Sphingosine Kinase 1 Degradation (2010) (64)
IL-18 is expressed in the intercalated cell of human kidney. (2007) (63)
Extracellular ATP and UTP activate the protein kinase B/Akt cascade via the P2Y2 purinoceptor in renal mesangial cells (2002) (63)
Regulation of eNOS in normal and diabetes-impaired skin repair: implications for tissue regeneration. (2002) (63)
CD14 works with toll-like receptor 2 to contribute to recognition and control of Listeria monocytogenes infection. (2008) (63)
Effect of extracellular ATP on contraction, cytosolic calcium activity, membrane voltage and ion currents of rat mesangial cells in primary culture (1993) (62)
Role of phospholipase C and protein kinase C in vasoconstrictor-induced prostaglandin synthesis in cultured rat renal mesangial cells. (1986) (62)
Nitric Oxide Induces Degradation of the Neutral Ceramidase in Rat Renal Mesangial Cells and Is Counterregulated by Protein Kinase C* (2002) (62)
Effect of cyclic AMP and prostaglandin E2 on the induction of nitric oxide- and prostanoid-forming pathways in cultured rat mesangial cells. (1996) (62)
Dimethylfumarate reduces leukocyte rolling in vivo through modulation of adhesion molecule expression. (2008) (61)
Lipoteichoic acid induces delayed protection in the rat heart: A comparison with endotoxin. (2000) (61)
Nitric oxide induces MIP‐2 transcription in rat renal mesangial cells and in a rat model of glomerulonephritis (2001) (61)
Down-regulation of protein kinase C potentiates angiotensin II-stimulated polyphosphoinositide hydrolysis in vascular smooth-muscle cells. (1989) (61)
Thrombolysis with recombinant tissue plasminogen activator under dabigatran anticoagulation in experimental stroke (2012) (60)
Role of prostaglandins in hypoxia-stimulated erythropoietin production. (1985) (60)
THERAPEUTIC STRATEGIES FOR THE INHIBITION OF INDUCIBLE NITRIC OXIDE SYNTHASE—POTENTIAL FOR A NOVEL CLASS OF ANTI‐INFLAMMATORY AGENTS (1996) (60)
IL‐22 in tissue‐protective therapy (2013) (60)
Cytokine- and forskolin-induced synthesis of group II phospholipase A2 and prostaglandin E2 in rat mesangial cells is prevented by dexamethasone. (1991) (59)
Glucocorticoids potently block tumour necrosis factor‐α‐ and lipopolysaccharide‐induced apoptotic cell death in bovine glomerular endothelial cells upstream of caspase 3 activation (1999) (59)
Regulation and immunhistochemical localization of nitric oxide synthases and soluble guanylyl cyclase in mouse spinal cord following nociceptive stimulation (2000) (59)
Nitric oxide stimulates stress‐activated protein kinases in glomerular endothelial and mesangial cells (1996) (59)
Dexamethasone inhibits TNF‐α‐induced apoptosis and IAP protein downregulation in MCF‐7 cells (2001) (59)
Immunocharacterization of δ‐ and ζ‐isoenzymes of protein kinase C in rat renal mesangial cells (1992) (58)
IL-18 initiates release of matrix metalloproteinase-9 from peripheral blood mononuclear cells without affecting tissue inhibitor of matrix metalloproteinases-1: suppression by TNFα blockage and modulation by IL-10 (2002) (57)
Prediction of acute renal allograft rejection by urinary monokine induced by IFN-gamma (MIG). (2005) (57)
Nitric oxide and mechanisms of redox signalling: matrix and matrix-metabolizing enzymes as prime nitric oxide targets. (2001) (56)
Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner (2008) (56)
Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P3 in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone (2009) (56)
CXCL16 and oxLDL are induced in the onset of diabetic nephropathy (2009) (56)
The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma. (2011) (55)
The ceramide kinase inhibitor NVP‐231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death (2014) (55)
Angiotensin II induces renal plasminogen activator inhibitor-1 and cyclooxygenase-2 expression post-transcriptionally via activation of the mRNA-stabilizing factor human-antigen R. (2009) (55)
Histamine increases sphingosine kinase-1 expression and activity in the human arterial endothelial cell line EA.hy 926 by a PKC-alpha-dependent mechanism. (2006) (55)
Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy. (2006) (55)
Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo. (2015) (55)
Extracellular ATP and UTP activation of phospholipase D is mediated by protein kinase C‐ε in rat renal mesangial cells (1993) (54)
Characterization of CXCL16 and ADAM10 in the normal and transplanted kidney. (2008) (54)
Immunocharacterization of protein kinase C isoenzymes in rat kidney glomeruli, and cultured glomerular epithelial and mesangial cells. (1993) (54)
Systemically and topically supplemented leptin fails to reconstitute a normal angiogenic response during skin repair in diabetic ob/ob mice (2001) (53)
IL-36γ/IL-1F9, an Innate T-bet Target in Myeloid Cells* (2012) (53)
Apoptotic Cell-Derived Sphingosine-1-Phosphate Promotes HuR-Dependent Cyclooxygenase-2 mRNA Stabilization and Protein Expression1 (2008) (53)
Serum acid sphingomyelinase is upregulated in chronic hepatitis C infection and non alcoholic fatty liver disease. (2014) (53)
Identification of copper/zinc superoxide dismutase as a novel nitric oxide‐regulated gene in rat glomerular mesangial cells and kidneys of endotoxemic rats (1999) (53)
Platelet-derived growth factor and fibroblast growth factor differentially regulate interleukin 1beta- and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells. (1997) (53)
Extracellular nucleotides activate the p38‐stress‐activated protein kinase cascade in glomerular mesangial cells (2000) (53)
Cyclic AMP mimics, but does not mediate, interleukin-1- and tumour-necrosis-factor-stimulated phospholipase A2 secretion from rat renal mesangial cells. (1991) (52)
Serum sphingolipidomic analyses reveal an upregulation of C16- ceramide and sphingosine-1-phosphate in hepatocellular carcinoma (2016) (52)
Parathyroid hormone inhibition of Na+/phosphate cotransport in OK cells: generation of second messengers in the regulatory cascade. (1989) (52)
Interleukin 1 beta-induced expression of nitric oxide synthase in rat renal mesangial cells is suppressed by cyclosporin A. (1995) (52)
High-constitutive HuR phosphorylation at Ser 318 by PKC{delta} propagates tumor relevant functions in colon carcinoma cells. (2011) (52)
Potentiation of nitric oxide synthase expression by superoxide in interleukin 1β‐stimulated rat mesangial cells (1998) (52)
Cross-talk between nitric oxide and superoxide determines ceramide formation and apoptosis in glomerular cells. (2002) (52)
Nitric Oxide Induces TIMP-1 Expression by Activating the Transforming Growth Factor β-Smad Signaling Pathway* (2005) (51)
In-vivo interaction of nitric oxide and endothelin (2004) (51)
Oncostatin M expression is functionally connected to neutrophils in the early inflammatory phase of skin repair: implications for normal and diabetes-impaired wounds. (2006) (51)
Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor β signalling and angiogenesis. (2015) (51)
Extracellular ATP stimulates polyphosphoinositide hydrolysis and prostaglandin synthesis in rat renal mesangial cells. Involvement of a pertussis toxin-sensitive guanine nucleotide binding protein and feedback inhibition by protein kinase C. (1990) (51)
Cyclosporin derivatives inhibit interleukin 1 beta induction of nitric oxide synthase in renal mesangial cells. (1993) (50)
Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study (2012) (50)
Junctional adhesion molecule (JAM)‐B supports lymphocyte rolling and adhesion through interaction with α4β1 integrin (2009) (50)
Regulation of the mRNA-binding protein HuR by posttranslational modification: spotlight on phosphorylation. (2012) (50)
Keratinocyte-derived chemotactic cytokines: expressional modulation by nitric oxide in vitro and during cutaneous wound repair in vivo. (2000) (50)
Epitope spreading of the anti-CYP2D6 antibody response in patients with autoimmune hepatitis and in the CYP2D6 mouse model. (2011) (49)
Nitric oxide stimulates the stress-activated protein kinase p38 in rat renal mesangial cells. (1999) (49)
FTY720 Treatment in the Convalescence Period Improves Functional Recovery and Reduces Reactive Astrogliosis in Photothrombotic Stroke (2013) (49)
Downregulation of junctional adhesion molecule-A is involved in the progression of clear cell renal cell carcinoma. (2009) (48)
Targeting caspase-1 by inhalation-therapy: effects of Ac-YVAD-CHO on IL-1β, IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia (2007) (48)
Sphingosine-1-Phosphate Receptor-2 Antagonists: Therapeutic Potential and Potential Risks (2016) (48)
Apoptosis and expression of inducible nitric oxide synthase are mutually exclusive in renal mesangial cells. (1997) (48)
Stimulation by extracellular ATP and UTP of the stress‐activated protein kinase cascade in rat renal mesangial cells (1997) (47)
Role of cGMP as second messenger of adenosine in the inhibition of renin release. (1988) (47)
Transforming growth factor β2 stimulates acute and chronic activation of the mitogen‐activated protein kinase cascade in rat renal mesangial cells (1994) (47)
L1-CAM expression in ccRCC correlates with shorter patients survival times and confers chemoresistance in renal cell carcinoma cells. (2011) (46)
Rapamycin induces the TGFbeta1/Smad signaling cascade in renal mesangial cells upstream of mTOR. (2009) (45)
A brief exposure to isoflurane (50 s) significantly impacts on plasma cytokine levels in endotoxemic rats. (2005) (45)
Suppression of apoptosis by glucocorticoids in glomerular endothelial cells: effects on proapoptotic pathways (2000) (45)
Determination of leptin signaling pathways in human and murine keratinocytes. (2003) (45)
Is renin secretion governed by the calcium permeability of the juxtaglomerular cell membrane? (1984) (44)
IL-27 Regulates IL-18 Binding Protein in Skin Resident Cells (2012) (44)
The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells. (2008) (44)
PPARalpha activation upregulates nephrin expression in human embryonic kidney epithelial cells and podocytes by a dual mechanism. (2005) (44)
p68 DEAD Box RNA Helicase Expression in Keratinocytes (2004) (44)
Early Production of IL-22 but Not IL-17 by Peripheral Blood Mononuclear Cells Exposed to live Borrelia burgdorferi: The Role of Monocytes and Interleukin-1 (2010) (43)
Angiotensin II B-type receptor mediates phosphoinositide hydrolysis in mesangial cells. (1990) (43)
The suppressor of cytokine signaling-3 is upregulated in impaired skin repair: implications for keratinocyte proliferation. (2006) (43)
Loss of sphingosine kinase‐1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin‐induced DNA damage (2011) (43)
Dexamethasone inhibits TNF-alpha-induced apoptosis and IAP protein downregulation in MCF-7 cells. (2001) (43)
Interleukin‐1β‐induced cytosolic phospholipase A2 activity and protein synthesis is blocked by dexamethasone in rat mesangial cells (1993) (43)
Interleukin‐18 secretion and Th1‐like cytokine responses in human peripheral blood mononuclear cells under the influence of the toll‐like receptor‐5 ligand flagellin (2006) (43)
Interleukin‐1 stimulates de novo synthesis of mitogen‐activated protein kinase in glomerular mesangial cells (1994) (41)
Distinct signaling pathways mediate phorbol-ester-induced and cytokine-induced inhibition of erythropoietin gene expression. (1994) (41)
Nitrosative and oxidative stress induced heme oxygenase-1 accumulation in rat mesangial cells. (1998) (41)
Regulation of interleukin-18 (IL-18) expression in keratinocytes (HaCaT): implications for early wound healing. (2000) (41)
Expression and release of chemokines associated with apoptotic cell death in human promonocytic U937 cells and peripheral blood mononuclear cells (1999) (41)
Tetrahydrobiopterin is a limiting factor of nitric oxide generation in interleukin 1 beta-stimulated rat glomerular mesangial cells. (1994) (41)
Tumour promotor 12‐O‐tetradecanoylphorbol 13‐acetate inhibits angiotensin II‐induced inositol phosphate production and cytosolic Ca2+ rise in rat renal mesangial cells (1986) (41)
Macrophage-Derived Heme-Oxygenase-1: Expression, Regulation, and Possible Functions in Skin Repair (2001) (41)
INTERLEUKIN-22 DETECTED IN PATIENTS WITH ABDOMINAL SEPSIS (2010) (41)
Platelet‐derived growth factor‐BB induces cystathionine γ‐lyase expression in rat mesangial cells via a redox‐dependent mechanism (2012) (40)
Characterization of group X phospholipase A(2) as the major enzyme secreted by human keratinocytes and its regulation by the phorbol ester TPA. (2001) (40)
Transforming growth factors type‐β and dexamethasone attenuate group II phospholipase A2 gene expression by interleukin‐1 and forskolin in rat mesangial cells (1992) (40)
Hypoxia and cobalt stimulate lactate dehydrogenase (LDH) activity in vascular smooth muscle cells (1994) (39)
Nitric oxide stimulates chronic ceramide formation in glomerular endothelial cells. (1999) (39)
Interleukin-1 beta and tumor necrosis factor-alpha synergistically stimulate nerve growth factor synthesis in rat mesangial cells. (1991) (39)
Extracellular nucleotides induce migration of renal mesangial cells by upregulating sphingosine kinase‐1 expression and activity (2007) (39)
Cytokine-induced expression of tPA is differentially modulated by NO and ROS in rat mesangial cells. (2002) (39)
Parathyroid hormone inhibition of Na+/phosphate cotransport in OK cells: requirement of protein kinase C-dependent pathway. (1989) (39)
Characterization and differentiation-dependent regulation of secreted phospholipases A in human keratinocytes and in healthy and psoriatic human skin. (2005) (38)
Release of phospholipase A2 activity from rat vascular smooth muscle cells mediated by cAMP. (1989) (38)
Cyclosporin A and tacrolimus induce renal Erk1/2 pathway via ROS-induced and metalloproteinase-dependent EGF-receptor signaling. (2012) (38)
Sphingolipid signaling in renal fibrosis. (2018) (38)
Dexamethasone suppresses interleukin‐22 associated with bacterial infection in vitro and in vivo (2009) (38)
Sphingosine 1-phosphate (S1P) induces COX-2 expression and PGE2 formation via S1P receptor 2 in renal mesangial cells. (2014) (38)
Interferon‐γ induces expression of interleukin‐18 binding protein in fibroblast‐like synoviocytes (2003) (38)
Expression of interleukin-8, heme oxygenase-1 and vascular endothelial growth factor in DLD-1 colon carcinoma cells exposed to pyrrolidine dithiocarbamate. (2002) (37)
Transforming growth factor beta 2 differentially modulates interleukin-1 beta- and tumour-necrosis-factor-alpha-stimulated phospholipase A2 and prostaglandin E2 synthesis in rat renal mesangial cells. (1990) (37)
Basic fibroblast growth factor selectively enhances TNF-alpha-induced apoptotic cell death in glomerular endothelial cells: effects on apoptotic signaling pathways. (2000) (37)
Pigment-Epithelium-Derived Factor Is Upregulated in Photocoagulated Human Retinal Pigment Epithelial Cells (2005) (37)
Different effects of phorbol ester on angiotensin II- and stable GTP analogue-induced activation of polyphosphoinositide phosphodiesterase in membranes isolated from rat renal mesangial cells. (1987) (37)
Treatment with the immunomodulator FTY720 does not promote spontaneous bacterial infections after experimental stroke in mice (2011) (37)
Alteration of sphingolipid metabolism as a putative mechanism underlying LPS‐induced BBB disruption (2018) (37)
Cyclosporin A augments vasoconstrictor-induced rise in intracellular free calcium in rat renal mesangial cells. (1988) (37)
Sphingosine 1-Phosphate in Renal Diseases (2013) (37)
Possible role of protein kinase C-epsilon isoenzyme in inhibition of interleukin 1 beta induction of nitric oxide synthase in rat renal mesangial cells. (1994) (37)
IFNα converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets. (2013) (36)
Variations in serum sphingolipid levels associate with liver fibrosis progression and poor treatment outcome in hepatitis C virus but not hepatitis B virus infection (2015) (36)
Cyclosporin A inhibits PGE2 release from vascular smooth muscle cells. (1987) (36)
Endothelial nitric oxide synthase: a determinant of TNFalpha production by human monocytes/macrophages. (2003) (36)
Platelet-derived growth factor inhibits cytokine induction of nitric oxide synthase in rat renal mesangial cells. (1991) (36)
Proteolytic cleavage of inducible nitric oxide synthase (iNOS) by calpain I. (2001) (35)
Inflammatory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes. (2003) (35)
PDGF suppresses the activation of group II phospholipase A2 gene expression by interleukin I and forskolin in mesangial cells (1991) (35)
No Influence of Dabigatran Anticoagulation on Hemorrhagic Transformation in an Experimental Model of Ischemic Stroke (2012) (35)
Protein kinase C from rat renal mesangial cells: its role in homologous desensitization of angiotensin II-induced polyphosphoinositide hydrolysis. (1988) (35)
Apoptosis is triggered by the cyclic AMP signalling pathway in renal mesangial cells (1996) (35)
Evidence for a link between histone deacetylation and Ca²+ homoeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts. (2012) (35)
Differentiation-dependent regulation of secreted phospholipases A2 in murine epidermis. (2003) (35)
Changing gears in the course of glomerulonephritis by shifting superoxide to nitric oxide-dominated chemistry. (2002) (34)
Differential modulation of the cytokine-induced MMP-9/TIMP-1 protease-antiprotease system by the mTOR inhibitor rapamycin. (2011) (34)
Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis (2016) (34)
CYP2R1-, CYP27B1- and CYP24-mRNA expression in German type 1 diabetes patients (2007) (34)
Interleukin-18 directly activates T-bet expression and function via p38 mitogen-activated protein kinase and nuclear factor-κB in acute myeloid leukemia–derived predendritic KG-1 cells (2007) (34)
Molecular mechanisms of nitric oxide‐dependent inhibition of TPA‐induced matrix metalloproteinase‐9 (MMP‐9) in MCF‐7 cells (2009) (34)
Nitric oxide augments release of chemokines from monocytic U937 cells: modulation by anti-inflammatory pathways. (2000) (33)
Nitric oxide triggers the expression of proinflammatory and protective gene products in mesangial cells and the inflamed glomerulus. (2002) (33)
Serum Sphingolipid Variations Associate with Hepatic Decompensation and Survival in Patients with Cirrhosis (2015) (33)
The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen. (2011) (33)
Protein kinase C phosphorylates and activates GTP cyclohydrolase I in rat renal mesangial cells. (1998) (33)
Cellular mechanisms of ATP‐induced hyperpolarization in renal epitheloid MDCK‐cells (1991) (33)
Potentiation of angiotensin II‐stimulated phosphoinositide hydrolysis, calcium mobilization and contraction of renal mesangial cells upon down‐regulation of protein kinase C (1990) (33)
TLR-ligand stimulated interleukin-23 subunit expression and assembly is regulated differentially in murine plasmacytoid and myeloid dendritic cells. (2007) (33)
Does nitric oxide, an inflammatory mediator of glomerular mesangial cells, have a role in diabetic nephropathy? (1995) (32)
Targeting the sphingosine kinase/sphingosine 1-phosphate pathway to treat chronic inflammatory kidney diseases. (2014) (32)
Coordinated induction of inducible nitric oxide synthase and GTP-cyclohydrolase I is dependent on inflammatory cytokines and interferon-gamma in HaCaT keratinocytes: implications for the model of cutaneous wound repair. (1998) (32)
Pyrrolidine dithiocarbamate differentially affects cytokine‐ and cAMP‐induced expression of group II phospholipase A2 in rat renal mesangial cells (1995) (32)
Interleukin 1 beta and cAMP trigger the expression of GTP cyclohydrolase I in rat renal mesangial cells. (1996) (32)
Failure of Interferon γ to Induce the Anti-Inflammatory Interleukin 18 Binding Protein in Familial Hemophagocytosis (2010) (32)
‘Antiflammins’: Two nonapeptide fragments of uteroglobin and lipocortin I have no phospholipase A2 ‐inhibitory and anti‐inflammatory activity (1990) (32)
PS3, a semisynthetic beta-1,3-glucan sulfate, diminishes contact hypersensitivity responses through inhibition of L- and P-selectin functions. (2009) (32)
A role for protein kinase C‐α in zymosan‐stimulated eicosanoid synthesis in mouse peritoneal macrophages (1993) (31)
Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction. (2017) (31)
Protein kinase C inhibitors potentiate angiotensin II-induced phosphoinositide hydrolysis and intracellular Ca2+ mobilization in renal mesangial cells. (1993) (31)
Differential binding of ceramide to MEKK1 in glomerular endothelial and mesangial cells. (2004) (31)
Molecular mechanisms of IL‐18BP regulation in DLD‐1 cells: pivotal direct action of the STAT1/GAS axis on the promoter level (2009) (31)
ADAM10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases (2010) (30)
Sphingosine Kinase1 Is Pivotal for FcεRI-Mediated Mast Cell Signaling and Functional Responses In Vitro and In Vivo (2009) (30)
Anti-inflammatory steroids inhibit cytokine induction of nitric oxide synthase in rat renal mesangial cells. (1991) (30)
Extracellular ATP stimulates poly(inositol phospholipid) hydrolysis and eicosanoid synthesis in mouse peritoneal macrophages in culture. (1989) (30)
Nitric oxide and mechanisms of redox signaling. (2003) (30)
Amplification of nitric oxide synthase expression by nitric oxide in interleukin 1beta-stimulated rat mesangial cells. (1996) (30)
Ceramide Kinase Contributes to Proliferation but not to Prostaglandin E2 Formation in Renal Mesangial Cells and Fibroblasts (2014) (29)
Application of IL-36 receptor antagonist weakens CCL20 expression and impairs recovery in the late phase of murine acetaminophen-induced liver injury (2015) (29)
Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants (2017) (29)
Molecular mechanisms of cyclosporin A inhibition of the cytokine-induced matrix metalloproteinase-9 in glomerular mesangial cells. (2007) (29)
Regulatory functions of protein kinase C isoenzymes in purinoceptor signalling in mesangial cells. (1996) (29)
Unravelling green tea's mechanisms of action: more than meets the eye. (2004) (28)
The cytoskeletal inhibitors latrunculin A and blebbistatin exert antitumorigenic properties in human hepatocellular carcinoma cells by interfering with intracellular HuR trafficking. (2015) (28)
Ceramide induces translocation of protein kinase C-alpha to the Golgi compartment of human embryonic kidney cells by interacting with the C2 domain. (2003) (28)
Short-term exposure to high-pressure ventilation leads to pulmonary biotrauma and systemic inflammation in the rat. (2008) (28)
The suppressor of cytokine signaling (SOCS)-3 determines keratinocyte proliferative and migratory potential during skin repair. (2010) (28)
Genome-wide analysis displays marked induction of EBI3/IL-27B in IL-18-activated AML-derived KG1 cells: critical role of two kappaB binding sites in the human EBI3 promotor. (2008) (28)
Domain-specific phosphomimetic mutation allows dissection of different protein kinase C (PKC) isotype-triggered activities of the RNA binding protein HuR. (2013) (27)
Light-induced phosphoinositide degradation and light-induced structural alterations in the rat retina are enhanced after chronic lithium treatment. (1988) (27)
Inhibition of erythropoietin production by phorbol ester is associated with down-regulation of protein kinase C-alpha isoenzyme in hepatoma cells. (1991) (27)
Nitric oxide induces neutral ceramidase degradation by the ubiquitin/proteasome complex in renal mesangial cell cultures (2002) (27)
Cross‐talk between group IIA‐phospholipase A2 and inducible NO‐synthase in rat renal mesangial cells (1999) (27)
Non-alcoholic fatty liver disease (NAFLD) potentiates autoimmune hepatitis in the CYP2D6 mouse model. (2016) (27)
Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA (2009) (27)
Mechanism of autoimmune hepatic fibrogenesis induced by an adenovirus encoding the human liver autoantigen cytochrome P450 2D6. (2013) (27)
Silencing of the mRNA-binding protein HuR increases the sensitivity of colorectal cancer cells to ionizing radiation through upregulation of caspase-2. (2017) (26)
H2S-induced thiol-based redox switches: Biochemistry and functional relevance for inflammatory diseases. (2016) (26)
On the induction of cyclooxygenase-2, inducible nitric oxide synthase and soluble phospholipase A2 in rat mesangial cells by a nonsteroidal anti-inflammatory drug: the role of cyclic AMP. (1998) (26)
A role for protein kinase C‐ϵ in angiotensin II stimulation of phospholipase D in rat renal mesangial cells (1993) (26)
Increased Serum Levels of the IL‐33 Neutralizing sST2 in Limited Cutaneous Systemic Sclerosis (2015) (26)
Upregulation of the S1P3 receptor in metastatic breast cancer cells increases migration and invasion by induction of PGE2 and EP2/EP4 activation. (2016) (26)
Interleukin-1beta induces chronic activation and de novo synthesis of neutral ceramidase in renal mesangial cells. (2001) (26)
A Prominent Role of Interleukin-18 in Acetaminophen-Induced Liver Injury Advocates Its Blockage for Therapy of Hepatic Necroinflammation (2018) (26)
Heterologous desensitization of the sphingosine‐1‐phosphate receptors by purinoceptor activation in renal mesangial cells (2004) (26)
Simultaneous and Dose Dependent Melanoma Cytotoxic and Immune Stimulatory Activity of Betulin (2015) (26)
Desflurane differentially affects the release of proinflammatory cytokines in plasma and bronchoalveolar fluid of endotoxemic rats. (2006) (26)
Warfarin Anticoagulation Exacerbates the Risk of Hemorrhagic Transformation after rt-PA Treatment in Experimental Stroke: Therapeutic Potential of PCC (2011) (25)
Immunopharmacology: anti-inflammatory therapy targeting transcription factors. (1999) (25)
Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase (2019) (25)
The induction of cellular group II phospholipase A2 by cytokines and its prevention by dexamethasone. (1992) (25)
Regulation of inhibitor of apoptosis expression by nitric oxide and cytokines: relation to apoptosis induction in rat mesangial cells and raw 264.7 macrophages. (2001) (25)
Negative regulation of interleukin‐1β‐activated neutral sphingomyelinase by protein kinase C in rat mesangial cells (1998) (25)
The S1P–S1PR Axis in Neurological Disorders—Insights into Current and Future Therapeutic Perspectives (2020) (25)
Suppression by cyclosporin A of interleukin 1β‐induced expression of group II phospholipase A2 in rat renal mesangial cells (1997) (25)
Lack of Interferon-γ Production Despite the Presence of Interleukin-18 During Cutaneous Wound Healing (2000) (25)
Thiazolidinedione‐dependent activation of sphingosine kinase 1 causes an anti‐fibrotic effect in renal mesangial cells (2012) (25)
Nitric oxide induces TIMP-1 expression by activating the transforming growth factor beta-Smad signaling pathway. (2005) (24)
Nephrin expression is increased in anti-Thy1.1-induced glomerulonephritis in rats. (2004) (24)
Angiotensin II stimulation of phospholipase D in rat renal mesangial cells is mediated by the AT1 receptor subtype. (1992) (24)
Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice (2014) (24)
Type I Interferon Supports Inducible Nitric Oxide Synthase in Murine Hepatoma Cells and Hepatocytes and during Experimental Acetaminophen-Induced Liver Damage (2017) (24)
Interleukin 1 and tumor necrosis factor potentiate angiotensin II- and calcium ionophore-stimulated prostaglandin E2 synthesis in rat renal mesangial cells. (1990) (23)
Rat GTP cyclohydrolase I is a homodecameric protein complex containing high-affinity calcium-binding sites. (1998) (23)
Epithelial overexpression of SOCS-3 in transgenic mice exacerbates wound inflammation in the presence of elevated TGF-beta1. (2010) (23)
Identification of manganese superoxide dismutase as a NO-regulated gene in rat glomerular mesangial cells by 2D gel electrophoresis. (2003) (23)
Nitric oxide and vascular remodeling: spotlight on the kidney. (2007) (23)
Ceramides as Key Players in Cellular Stress Response. (2000) (23)
Nitric oxide inhibits glomerular TGF-beta signaling via SMOC-1. (2009) (23)
Biphasic Regulation of HMG-CoA Reductase Expression and Activity during Wound Healing and Its Functional Role in the Control of Keratinocyte Angiogenic and Proliferative Responses* (2008) (23)
IL-18BPa:Fc cooperates with immunosuppressive drugs in human whole blood. (2003) (23)
Effects of dexamethasone and transforming growth factor-beta 2 on group II phospholipase A2 mRNA and activity levels in interleukin 1 beta- and forskolin-stimulated mesangial cells. (1996) (23)
Effects of homo- and heterodimeric isoforms of PDGF on signalling events in rat renal mesangial cells. (1991) (23)
Hypoxia enhances prostaglandin synthesis in renal mesangial cell cultures. (1985) (23)
Keratinocyte-Derived Vascular Endothelial Growth Factor Biosynthesis Represents a Pleiotropic Side Effect of Peroxisome Proliferator-Activated Receptor-γ Agonist Troglitazone but Not Rosiglitazone and Involves Activation of p38 Mitogen-Activated Protein Kinase: Implications for Diabetes-Impaired Ski (2008) (22)
Sphingosine kinase 1 is critically involved in nitric oxide‐mediated human endothelial cell migration and tube formation (2010) (22)
Norepinephrine and vasopressin counteract anti-inflammatory effects of isoflurane in endotoxemic rats. (2007) (22)
Parathyroid hormone inhibition of Na+/phosphate cotransport in OK cells: intracellular [Ca2+] as a second messenger. (1989) (22)
Inhibition of Rho modulates cytokine-induced prostaglandin E2 formation in renal mesangial cells. (2004) (22)
Deregulated unfolded protein response in chronic wounds of diabetic ob/ob mice: a potential connection to inflammatory and angiogenic disorders in diabetes-impaired wound healing. (2014) (22)
Pyrrolidine Dithiocarbamate Activates p38 MAPK and Protects Brain Endothelial Cells From Apoptosis: A Mechanism for the Protective Effect in Stroke? (2010) (22)
Angiotensin II stimulation of the stress-activated protein kinases in renal mesangial cells is mediated by the angiotensin AT1 receptor subtype. (1998) (22)
Mechanism of NaCl transport-stimulated prostaglandin formation in MDCK cells. (1987) (22)
Identification of ceramide targets in interleukin-1 and tumor necrosis factor-alpha signaling in mesangial cells. (1998) (22)
Differential recovery of protein kinase C-α and -ɛ isozymes after long-term phorbol ester treatment in rat renal mesangial cells (1991) (22)
An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis. (2016) (22)
Islet-Expressed CXCL10 Promotes Autoimmune Destruction of Islet Isografts in Mice With Type 1 Diabetes (2016) (22)
Angiotensin II type 1-receptor antagonism prevents type IIA secretory phospholipase A2-dependent lipid peroxidation. (2007) (22)
Uptake of neutrophil-derived Ym1 protein distinguishes wound macrophages in the absence of interleukin-4 signaling in murine wound healing. (2014) (21)
Downregulation of SPARC expression is mediated by nitric oxide in rat mesangial cells and during endotoxemia in the rat. (2000) (21)
PAX2 Regulates ADAM10 Expression and Mediates Anchorage-Independent Cell Growth of Melanoma Cells (2011) (21)
Cellular mechanisms of bradykinin-induced hyperpolarization in renal epitheloid MDCK-cells. (1991) (21)
Comparison of different tumour promoters and bryostatin 1 on protein kinase C activation and down-regulation in rat renal mesangial cells. (1994) (21)
IFN-gamma Impairs Release of IL-8 by IL-1beta-stimulated A549 Lung Carcinoma Cells (2008) (20)
Upregulation of group IB secreted phospholipase A(2) and its M-type receptor in rat ANTI-THY-1 glomerulonephritis. (2006) (20)
Anti-CD3/Anti-CXCL10 Antibody Combination Therapy Induces a Persistent Remission of Type 1 Diabetes in Two Mouse Models (2015) (20)
RNA-dependent association with myosin IIA promotes F-actin-guided trafficking of the ELAV-like protein HuR to polysomes (2013) (20)
ADAM15 expression is downregulated in melanoma metastasis compared to primary melanoma. (2010) (20)
Role of wound macrophages in skin flap loss or survival in an experimental diabetes model (2010) (20)
Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI 3-Kinase and Akt (2020) (20)
Modulation of tissue plasminogen activator and plasminogen activator inhibitor-1 by transforming growth factor-beta in human retinal glial cells. (2002) (20)
Superoxide potently induces ceramide formation in glomerular endothelial cells. (2001) (20)
Pharmacological properties of five diclofenac metabolites identified in human plasma (1991) (20)
Potentiation of TNF-α–Stimulated Group IIA Phospholipase A2 Expression by Peroxisome Proliferator–Activated Receptor α Activators in Rat Mesangial Cells (2002) (20)
Endothelial Cell Cystathionine γ‐Lyase Expression Level Modulates Exercise Capacity, Vascular Function, and Myocardial Ischemia Reperfusion Injury (2020) (20)
FTY720 and two novel butterfly derivatives exert a general anti-inflammatory potential by reducing immune cell adhesion to endothelial cells through activation of S1P3 and phosphoinositide 3-kinase (2015) (19)
Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance to FTY720 but not ST-968 treatments (2016) (19)
Interferon-gamma induces expression of interleukin-18 binding protein in fibroblast-like synoviocytes. (2003) (19)
Nitric oxide differentially regulates pro‐ and anti‐angiogenic markers in DLD‐1 colon carcinoma cells (2004) (19)
NaCl transport stimulates prostaglandin release in cultured renal epithelial (MDCK) cells. (1986) (19)
Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L (2014) (19)
Differential effect of dexamethasone on interleukin 1β‐ and cyclic AMP‐triggered expression of GTP cyclohydrolase I in rat renal mesangial cells (1997) (19)
Cellular signalling in the kidney: the role of inositol lipids. (1989) (19)
Erythropoietin is more than just a promoter of erythropoiesis. (2004) (19)
Small molecule CXCR3 antagonist NIBR2130 has only a limited impact on type 1 diabetes in a virus‐induced mouse model (2011) (18)
Glucocorticoids protect renal mesangial cells from apoptosis by increasing cellular sphingosine-1-phosphate. (2010) (18)
Ncf1 Provides a Reactive Oxygen Species-Independent Negative Feedback Regulation of TLR9-Induced IL-12p70 in Murine Dendritic Cells1 (2009) (18)
Hypoxia increases group IIA phospholipase A(2) expression under inflammatory conditions in rat renal mesangial cells. (2005) (18)
Influence of the vitamin D plasma level and vitamin D‐related genetic polymorphisms on the immune status of patients with type 1 diabetes: a pilot study (2013) (18)
Pharmacology of the sphingosine-1-phosphate signalling system. (2013) (18)
Dissociated glucocorticoids equipotently inhibit cytokine- and cAMP-induced matrix degrading proteases in rat mesangial cells. (2005) (18)
Interleukin 1‐ and tumor necrosis factor‐stimulation of prostaglandin E2 synthesis in MDCK cells, and potentiation of this effect by cycloheximide (1990) (18)
Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells (2018) (18)
Coexpression of inducible NO synthase and soluble guanylyl cyclase in colonic enterocytes: a pathophysiologic signaling pathway for the initiation of diarrhea by gram‐negative bacteria? (1998) (17)
Platelet, not endothelial, P-selectin expression contributes to generation of immunity in cutaneous contact hypersensitivity. (2010) (17)
Angiotensin II binding sites on micro-organisms contaminating cell cultures (1993) (17)
Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells (2018) (17)
Upregulation of ABC transporters contributes to chemoresistance of sphingosine 1-phosphate lyase-deficient fibroblasts (2015) (17)
Redox Signaling in Mesangial Cells (2003) (17)
Potentiation of cytokine induction of group IIA phospholipase A2 in rat mesangial cells by ATP and adenosine via the A2A adenosine receptor (2001) (17)
FTY720 suppresses interleukin‐1β‐induced secretory phospholipase A2 expression in renal mesangial cells by a transcriptional mechanism (2007) (17)
Serum sphingolipids predict de novo hepatocellular carcinoma in hepatitis C cirrhotic patients with sustained virologic response (2019) (17)
Sphingosine kinase 2 deficiency increases proliferation and migration of renal mouse mesangial cells and fibroblasts (2015) (17)
Activated protein C downregulates p38 mitogen-activated protein kinase and improves clinical parameters in an in-vivo model of septic shock (2007) (17)
Protein kinase C in the rat retina: immunocharacterization of calcium-independent δ, ϵ and ζ isoenzymes (1992) (17)
Tristetraprolin regulation of interleukin-22 production (2015) (16)
Platelet-derived growth factor stimulates de-novo synthesis of mitogen-activated protein kinase in renal mesangial cells. (1995) (16)
Defective IL-23/IL-17 Axis Protects p47phox−/− Mice from Colon Cancer (2017) (16)
Persistence of HCV in Acutely-Infected Patients Depletes C24-Ceramide and Upregulates Sphingosine and Sphinganine Serum Levels (2016) (16)
The HIV protease inhibitor ritonavir synergizes with butyrate for induction of apoptotic cell death and mediates expression of heme oxygenase‐1 in DLD‐1 colon carcinoma cells (2004) (16)
Blood ceramides as novel markers for renal impairment in systemic lupus erythematosus. (2019) (16)
Tight Spatial and Temporal Control in Dynamic Basal to Distal Migration of Epithelial Inflammatory Responses and Infiltration of Cytoprotective Macrophages Determine Healing Skin Flap Transplants in Mice (2009) (16)
Increase of cystathionine-γ-lyase (CSE) during late wound repair: Hydrogen sulfide triggers cytokeratin 10 expression in keratinocytes. (2019) (16)
Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study (2017) (15)
Effects of high glucose on cytokine-induced nerve growth factor (NGF) expression in rat renal mesangial cells. (2003) (15)
Susceptibility of interleukin 1- and tumour necrosis factor-induced prostaglandin E2 and phospholipase A2 release from rat renal mesangial cells to different drugs (1989) (15)
Preanalytical Biases in the Measurement of Human Blood Sphingolipids (2018) (15)
Downregulation of integrin-linked kinase mRNA expression by nitric oxide in rat glomerular mesangial cells. (2001) (15)
Systematic analysis highlights the key role of TLR2/NF-kappaB/MAP kinase signaling for IL-8 induction by macrophage-like THP-1 cells under influence of Borrelia burgdorferi lysates. (2008) (15)
Inhibition of renin secretion by platelet activating factor (acetylglyceryl ether phosphorylcholine) in cultured rat renal juxtaglomerular cells. (1985) (15)
Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage (2017) (15)
Inhibition of cyclooxygenase‐1 and ‐2 activity in keratinocytes inhibits PGE2 formation and impairs vascular endothelial growth factor release and neovascularisation in skin wounds (2017) (15)
Feedback regulation of extracellular ATP-stimulated phosphoinositide hydrolysis by protein kinase C-alpha in bovine glomerular endothelial cells. (1997) (15)
Cellular mechanisms of adrenaline-induced hyperpolarization in renal epitheloid MDCK cells. (1991) (15)
Anti-Inflammatory Effects of Rosiglitazone in Obesity-Impaired Wound Healing Depend on Adipocyte Differentiation (2016) (14)
Tetranactin inhibits interleukin 1 beta and cAMP induction of group II phospholipase A2 in rat renal mesangial cells. (1996) (14)
Vitamin D Supplementation Enhances C18(dihydro)ceramide Levels in Type 2 Diabetes Patients (2017) (14)
Multifaceted Roles of TRIM Proteins in Colorectal Carcinoma (2020) (14)
Mechanisms of Rapid Induction of Interleukin-22 in Activated T Cells and Its Modulation by Cyclosporin A* (2011) (14)
Activation-Induced Cell Death of Dendritic Cells Is Dependent on Sphingosine Kinase 1 (2016) (14)
Sphingosine Kinase 2 Modulates Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy. (2018) (14)
Mechanisms of Suppression of Inducible Nitric-oxide Synthase (iNOS) Expression in Interferon (IFN)-γ-stimulated RAW 264.7 Cells by Dexamethasone (1997) (14)
The pharmacological profile of CGP 28238, a novel highly potent anti-inflammatory compound. (1989) (14)
The H2S-producing enzyme CSE is dispensable for the processing of inflammatory and neuropathic pain (2015) (14)
Platelet-derived growth factor triggers PKA-mediated signalling by a redox-dependent mechanism in rat renal mesangial cells. (2013) (14)
Nitric oxide upregulates induction of PDGF receptor-alpha expression in rat renal mesangial cells and in anti-Thy-1 glomerulonephritis. (2005) (14)
PPARγ agonists upregulate sphingosine 1-phosphate (S1P) receptor 1 expression, which in turn reduces S1P-induced [Ca(2+)]i increases in renal mesangial cells. (2013) (13)
Eukaryotic expression of the broad‐spectrum chemokine receptor antagonist vMIP‐II and its effects on T‐cell function in vitro and in vivo (2006) (13)
Transforming growth factor beta 2 inhibits interleukin 1 beta- and tumour necrosis factor alpha-induction of nitric oxide synthase in rat renal mesangial cells. (1991) (13)
Angiogenic response pattern during normal and impaired skin flap re-integration in mice: a comparative study. (2014) (13)
CXCL9 Causes Heterologous Desensitization of CXCL12-Mediated Memory T Lymphocyte Activation (2013) (13)
Mechanisms of dexamethasone-mediated inhibition of cAMP-induced tPA expression in rat mesangial cells. (2002) (13)
Effect of synthetic atrial natriuretic peptide on rat renal juxtaglomerular cells. (1986) (13)
Translocation of protein kinase C isoenzymes by elevated extracellular Ca2+ concentration in cells from a human giant cell tumor of bone. (1995) (13)
Interleukin 1 beta and tumour necrosis factor alpha induce a macrophage-type of nitric oxide synthase in rat renal mesangial cells. (1992) (13)
Transforming growth factor beta 2 stimulates acute and chronic activation of the mitogen-activated protein kinase cascade in rat renal mesangial cells. (1994) (12)
Junctional adhesion molecules JAM-B and JAM-C promote autoimmune-mediated liver fibrosis in mice. (2018) (12)
Phospholipase A2 in mesangial cells: control mechanisms and functional importance. (1997) (12)
Cerivastatin inhibits proliferation of interleukin-1 beta-induced rat mesangial cells by enhanced formation of nitric oxide. (2004) (12)
Identification of the LIM kinase-1 as a ceramide-regulated gene in renal mesangial cells. (2002) (12)
A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke (2020) (12)
Light evoked inositol trisphosphate release in the rat retina in vitro. (1993) (12)
Interferon-Beta Increases Plasma Ceramides of Specific Chain Length in Multiple Sclerosis Patients, Unlike Fingolimod or Natalizumab (2016) (12)
Murine junctional adhesion molecules JAM-B and JAM-C mediate endothelial and stellate cell interactions during hepatic fibrosis (2016) (12)
Proliferative mechanisms in kidney cells. (1995) (11)
Transforming growth factor β2 (TGF-β2)-induced connective tissue growth factor (CTGF) expression requires sphingosine 1-phosphate receptor 5 (S1P5) in human mesangial cells. (2015) (11)
Inflammation-Induced Mucosal KYNU Expression Identifies Human Ileal Crohn’s Disease (2020) (11)
Control of Phospholipase A2 Gene Expression (1997) (11)
Cytoskeleton-Dependent Transport as a Potential Target for Interfering with Post-transcriptional HuR mRNA Regulons (2016) (11)
A new class of inhibitors of secretory phospholipase A2: enolized 1,3-dioxane-4,6-dione-5-carboxamides (1994) (11)
Inhibition of lipopolysaccharide/ATP-induced release of interleukin-18 by KN-62 and glyburide. (2003) (11)
Downregulation of S1P Lyase Improves Barrier Function in Human Cerebral Microvascular Endothelial Cells Following an Inflammatory Challenge (2020) (11)
Interleukin-1 inhibits angiotensin II-stimulated protein kinase B pathway in renal mesangial cells via the inducible nitric oxide synthase. (2002) (11)
Modulation of cytokine-induced expression of secretory phospholipase A2-type IIA by protein kinase C in rat renal mesangial cells. (1999) (11)
Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1β-induced prostaglandin E2 formation Published, JLR Papers in Press, June 25, 2007. (2007) (10)
Expanding extracellular zinc beyond levels reflecting the albumin-bound plasma zinc pool potentiates the capability of IL-1beta, IL-18, and IL-12 to Act as IFN-gamma-inducing factors on PBMC. (2007) (10)
Inhibition of NFκB‐mediated pro‐inflammatory gene expression in rat mesangial cells by the enolized 1,3‐dioxane‐4,6‐dione‐5‐carboxamide, CGP‐43182 (2000) (10)
Fingolimod targeting protein phosphatase 2A differently affects IL‐33 induced IL‐2 and IFN‐γ production in CD8+ lymphocytes (2016) (10)
Tissue Cytokine IL-33 Modulates the Cytotoxic CD8 T Lymphocyte Activity During Nutrient Deprivation by Regulation of Lineage-Specific Differentiation Programs (2019) (10)
Transforming growth factor-β2 inhibits interleukin 1β-induced expression of inducible nitric oxide synthase in rat renal mesangial cells (1997) (10)
Blockade but Not Overexpression of the Junctional Adhesion Molecule C Influences Virus-Induced Type 1 Diabetes in Mice (2013) (9)
Identification of TRIM25 as a Negative Regulator of Caspase-2 Expression Reveals a Novel Target for Sensitizing Colon Carcinoma Cells to Intrinsic Apoptosis (2019) (9)
Inhibition by tetranactin of interleukin 1β‐ and cyclic AMP‐induced nitric oxide synthase expression in rat renal mesangial cells (1996) (9)
Modulatory role of platelet-derived growth factor on cytokine-induced nerve growth factor synthesis in rat glomerular mesangial cells. (1995) (9)
Cytokine regulation of Group II phospholipase A2 expression in glomerular mesangial cells (2005) (9)
Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice. (2021) (9)
Alterations of the Ceramide Metabolism in the Peri-Infarct Cortex Are Independent of the Sphingomyelinase Pathway and Not Influenced by the Acid Sphingomyelinase Inhibitor Fluoxetine (2015) (9)
Cooperation between the bacterial‐derived short‐chain fatty acid butyrate and interleukin‐22 detected in human Caco2 colon epithelial/carcinoma cells (2017) (9)
Potentiation of TNF-alpha-stimulated group IIA phospholipase A(2) expression by peroxisome proliferator-activated receptor alpha activators in rat mesangial cells. (2002) (9)
[Measles in 2010. Knowledge and vaccination status of medical students]. (2011) (9)
Novel compounds with dual S1P receptor agonist and histamine H3 receptor antagonist activities act protective in a mouse model of multiple sclerosis (2021) (9)
Nuclear Translocation of SGPP-1 and Decrease of SGPL-1 Activity Contribute to Sphingolipid Rheostat Regulation of Inflammatory Dendritic Cells (2017) (8)
Comparing hemodynamics, blood gas analyses and proinflammatory cytokines in endotoxemic and severely septic rats. (2011) (8)
Computer‐aided analysis of cell interactions under dynamic flow conditions (2009) (8)
The Pathophysiology of H2S in Renal Glomerular Diseases (2022) (8)
Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase. (2020) (8)
Potentiation by light of lithium-induced retinal injury in rats. (1987) (7)
S1P d20:1, an endogenous modulator of S1P d18:1/S1P2‐dependent signaling (2020) (7)
Controlling the cytokine storm by insulin: glycogen synthase kinase-3 as a target in systemic inflammation. (2006) (7)
Cyclic AMP increases rat inhibitor of apoptosis protein (RIAP1) mRNA in renal mesangial cells. (2002) (7)
Enhanced expression of group IIA secreted phospholipase A2 by elevated glucose levels in cytokine-stimulated rat mesangial cells and in kidneys of diabetic rats. (2005) (7)
Epigenetic regulation by CpG methylation splits strong from retarded IFNγ-induced IL-18BP in epithelial versus monocytic cells. (2018) (7)
Impact of Moderna mRNA-1273 Booster Vaccine on Fully Vaccinated High-Risk Chronic Dialysis Patients after Loss of Humoral Response (2022) (7)
Modulation of IL‐33/ST2‐TIR and TLR Signalling Pathway by Fingolimod and Analogues in Immune Cells (2014) (7)
5-Hydroxytryptamine 5-HT1B receptors inhibiting cyclic AMP accumulation in rat renal mesangial cells (2004) (7)
Nitric Oxide Signalling with a Special Focus on Lipid-Derived Mediators (2003) (7)
Though Active on RINm5F Insulinoma Cells and Cultured Pancreatic Islets, Recombinant IL-22 Fails to Modulate Cytotoxicity and Disease in a Protocol of Streptozotocin-Induced Experimental Diabetes (2016) (7)
Subcellular distribution of FTY720 and FTY720-phosphate in immune cells – another aspect of Fingolimod action relevant for therapeutic application (2015) (7)
Identification of the Fra-1 transcription factor in healing skin flaps transplants: a potential role as a negative regulator of VEGF release from keratinocytes. (2012) (7)
Extracellular ATP and UTP activation of phospholipase D is mediated by protein kinase C-epsilon in rat renal mesangial cells. (1993) (7)
Low Serum Levels of (Dihydro-)Ceramides Reflect Liver Graft Dysfunction in a Real-World Cohort of Patients Post Liver Transplantation (2018) (7)
Gasotransmitter synthesis and signalling in the renal glomerulus. Implications for glomerular diseases. (2020) (7)
Thr308 determines Akt1 nuclear localization in insulin-stimulated keratinocytes. (2008) (7)
Interleukin‐1β inhibits ATP‐induced protein kinase B activation in renal mesangial cells by two different mechanisms: the involvement of nitric oxide and ceramide (2003) (7)
[Pharmacogenetics and pharmacogenomics of methotrexate. Current status and novel aspects]. (2011) (6)
Serum sphingolipid levels associate with upcoming virologic events and HBV genotype D in a cohort of patients with HBeAg-negative HBV infection (2018) (6)
Activation of renal profibrotic TGFβ controlled signaling cascades by calcineurin and mTOR inhibitors. (2018) (6)
Beta adrenoceptor blockade ameliorates impaired glucose tolerance and alterations of the cerebral ceramide metabolism in an experimental model of ischemic stroke (2018) (6)
Platelet-derived growth factor and fibroblast growth factor differentially regulate interleukin 1β- and cAMP-induced group II phospholipase A2 expression in rat renal mesangial cells (1998) (6)
Sorafenib Treatment and Modulation of the Sphingolipid Pathway Affect Proliferation and Viability of Hepatocellular Carcinoma In Vitro (2020) (6)
Consistent alteration of chain length-specific ceramides in human and mouse fibrotic kidneys. (2020) (6)
Vitamin D effects on sphingosine 1-phosphate signaling and metabolism in monocytes from type 2 diabetes patients and controls (2019) (6)
Diurnal regulation of sphingolipids in blood. (2019) (6)
Signalling pathways of nitric oxide. (2000) (6)
Simultaneous measurment of Ca2+ transients and shape changes in rat mesangial cells to evaluate the effects of recombinant human interleukin-1β (1992) (5)
Hypoxia and lipid signaling (2006) (5)
Regulatory functions of protein kinase c in glomerular mesangial cells (1990) (5)
Serum Sphingosine‐1‐Phosphate Is Decreased in Patients With Acute‐on‐Chronic Liver Failure and Predicts Early Mortality (2020) (5)
The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection (2021) (5)
Cytokine production by leukocytes of Papillon–Lefèvre syndrome patients in whole blood cultures (2012) (5)
cAMP potentiates interleukin 1- and tumor necrosis factor-stimulated phospholipase A2 secretion from rat renal mesangial cells (1990) (5)
H2O2 inhibits BCR-dependent immediate early induction of EBV genes in Burkitt's lymphoma cells. (2009) (5)
C6 Ceramide (d18:1/6:0) as a Novel Treatment of Cutaneous T Cell Lymphoma (2021) (5)
Hypothermia Promotes Interleukin-22 Expression and Fine-Tunes Its Biological Activity (2017) (5)
Interleukin-1 beta and transforming growth factor-beta 2 enhance cytosolic high-molecular-mass phospholipase A2 activity and induce prostaglandin E2 formation in rat mesangial cells. (1992) (5)
Transforming growth factor-beta 2 inhibits interleukin 1 beta-induced expression of inducible nitric oxide synthase in rat renal mesangial cells. (1997) (5)
Interleukin-1 beta-induced cytosolic phospholipase A2 activity and protein synthesis is blocked by dexamethasone in rat mesangial cells. (1993) (4)
Cytokines induce protein kinase A-mediated signalling by a redox-dependent mechanism in rat renal mesangial cells. (2015) (4)
Regulatory functions of protein kinase C isoenzymes in glomerular mesangial cells. (1994) (4)
Differential recovery of protein kinase C-alpha and -epsilon isozymes after long-term phorbol ester treatment in rat renal mesangial cells. (1991) (4)
[Lithium-induced lesions in the rat retina--potentiation by light]. (1988) (4)
Molecular mechanisms of PDGF-AA expression induced by the dsRNA-mimetic poly (I:C) and IL-18. (2013) (4)
A role for protein kinase C-epsilon in angiotensin II stimulation of phospholipase D in rat renal mesangial cells. (1993) (4)
Enhanced CXCR4 Expression of Human CD8Low T Lymphocytes Is Driven by S1P4 (2021) (4)
S1P Lyase siRNA Dampens Malignancy of DLD-1 Colorectal Cancer Cells. (2020) (4)
Validation of highly selective sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis. (2020) (4)
Interleukin-1 beta, tumor necrosis factor and forskolin stimulate the synthesis and secretion of group II phospholipase A2 in rat mesangial cells. (1991) (4)
Upregulation of matrilin‐2 expression in murine hepatic stellate cells during liver injury has no effect on fibrosis formation and resolution (2015) (3)
The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions (2022) (3)
Immunocharacterization of delta- and zeta-isoenzymes of protein kinase C in rat renal mesangial cells. (1992) (3)
Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile (2021) (3)
The atypical sphingosine 1‐phosphate variant, d16:1 S1P, mediates CTGF induction via S1P2 activation in renal cell carcinoma (2022) (3)
Nitric oxide mediates prolyl hydroxylase 3 expression in mesangial cells and in glomerulonephritis (2017) (3)
Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator. (2011) (3)
Reciprocal abrogation of PKM isoforms: contradictory outcomes and differing impact of splicing signal on CRISPR/Cas9 mediates gene editing in keratinocytes (2022) (3)
Downregulation of Cytokine-Induced Synthesis and Secretion of Group II Phospholipase A2 (1997) (3)
CERAMIDE-BINDING AND ACTIVATION DEFINES PROTEIN KINASE c-Raf AS A CERAMIDE ACTIVATED PROTEIN KINASE (1996) (3)
Effect of cell density on growth regulation of human glomerular epithelial cells. Inhibition of growth by dbcAMP and cAMP-elevating agonists. (1991) (3)
Betulin - a plant-derived cytostatic drug - enhances antitumor immune response (2014) (3)
Large induction of the chemokine RANTES during cutaneous wound repair A regulatory role for nitric oxide in keratinocyte-derived RANTES expression (2000) (3)
Effects of dexamethasone and transforming growth factor-β 2 on group II phospholipase A 2 mRNA and activity levels in interleukin 1 β-and forskolin-stimulated mesangial cells (1996) (2)
Oxidative Stress Injury in Glomerular Mesangium (2011) (2)
Interferon-c induces expression of interleukin-18 binding protein in fibroblast-like synoviocytes (2003) (2)
Renal Mesangial Cells Isolated from Sphingosine Kinase 2 Transgenic Mice Show Reduced Proliferation and are More Sensitive to Stress-Induced Apoptosis (2018) (2)
A role for protein kinase C-alpha in zymosan-stimulated eicosanoid synthesis in mouse peritoneal macrophages. (1993) (2)
NOS in Mesangial Cells: Physiological and Pathophysiological Roles (1997) (2)
Erythropoietin production in cultures of rat renal mesangial cells. (1986) (2)
Tumor necrosis factor-a and lipopolysaccharide induce apoptotic cell death in bovine glomerular endothelial cells (2015) (2)
Recuperation of Vascular Homeostasis. (2021) (2)
Nitric Oxide Inhibits Glomerular TGF- Signaling via SMOC-1 (2009) (2)
Sphingosine 1-Phosphate Receptor 5 (S1P5) Knockout Ameliorates Adenine-Induced Nephropathy (2022) (2)
Nitric Oxide and Gene Expression (2005) (2)
The Bologna agreement is not suitable for medical education: a German view (2010) (2)
Erratum: IL-1 family nomenclature (2011) (2)
A heterogeneous Ly-6B2+ leukocyte population consists of yet undescribed iNOS-expressing cell types in murine skin wounds. (2018) (2)
Interleukin 1 β and cAMP trigger the expression of GTP cyclohydrolase I in rat renal mesangial cells (1996) (2)
Effects of adenovirus‐induced hepatocyte damage on chronic bile duct inflammation in a sclerosing cholangitis mouse model (2019) (2)
Downregulation of sphingosine 1-phosphate (S1P) receptor 1 by dexamethasone inhibits S1P-induced mesangial cell migration (2015) (1)
Lymphotoxin α, a novel target of posttranscriptional gene regulation by HuR in HepG2 cells (2015) (1)
autocrine loop involving secreted phospholipase A2 and PPARα activation (2003) (1)
Regulation of Intracellular Calcium in Cultured Renal Epithelioid (MDCK-) Cells (1990) (1)
Sphk1 and Sphk2 Differentially Regulate Erythropoietin Synthesis in Mouse Renal Interstitial Fibroblast-like Cells (2022) (1)
National survey of evaluation practices and performance-guided resource allocation at German medical schools (2019) (1)
Phospholipases A2 and Prostaglandin Formation in Rat Glomerular Mesangial Cells (1994) (1)
The glomerular cell: source and target of various mediators. (1997) (1)
Guanine Nucleotide Regulatory Protein Couples Angiotensin II Receptors to Phospholipase C in Mesangial Cells (1987) (1)
47 Interleukin-22 in sepsis (2008) (1)
A murine cellular model of necroinflammation displays RAGE‐dependent cytokine induction that connects to hepatoma cell injury (2020) (1)
Correction for Doller et al., “Tandem Phosphorylation of Serines 221 and 318 by Protein Kinase Cδ Coordinates mRNA Binding and Nucleocytoplasmic Shuttling of HuR” (2017) (1)
Protein kinase C in the rat retina: immunocharacterization of calcium-independent delta, epsilon and zeta isoenzymes. (1992) (1)
The dsRNA-mimetic poly (I:C) and IL-18 synergize for IFNgamma and TNFalpha expression. (2009) (1)
Regulation of GTP Cyclohydrolase I by Estrogen (2002) (1)
Cytokine regulation of nitric oxide synthase expression in glomerular mesangial cells. (1994) (1)
Regulation of 14 kDa Group II PLA2 in Rat Mesangial Cells (1995) (1)
Simultaneous registration of Ca2+ transients and volume changes in rat mesangial cells: Evaluation of the effects of protein kinase C down-regulation (1992) (1)
Expression of Ubiquitin Carboxy-Terminal Hydrolase-L1 in Photocoagulated Human Retinal Pigment Epithelial Cells (2007) (1)
Dynamic interaction between sphingolipid enzymes, S1P and inflammatory cytokine regulation in dendritic cells (2014) (0)
Rat Mesangial Cells and cAMP in β Synthase Gene Expression by IL-1 Molecular Mechanisms of Inducible Nitric Oxide Pfeilschifter (1998) (0)
Retraction: Sphingosine Kinase1 Is Pivotal for Fc"RI-Mediated Mast Cell Signaling and Functional Responses In Vitro and In Vivo (2012) (0)
[Adhesion molecules]. (2000) (0)
PP27 - Proteomic analysis of cysteine persulfides in hydrogen sulfide-dependent signaling (2015) (0)
Cerivastatin enhanced mRNA and protein expression of the inducible NO synthase in rat mesangial cells (2001) (0)
Application of pseudotyped virus particles to monitor Ebola virus and SARS-CoV-2 viral entry in human cell lines (2021) (0)
Expression of Nox1 and formation of reactive oxygen species is attenuated by nitric oxide in rat mesangial cells. (2006) (0)
p47phox and its potential redox independent role in TLR signalling (2007) (0)
P0087 : Low serum C24 ceramide is predictive of hepatic decompensation and poor overall survival in liver cirrhosis (2015) (0)
Interferon-α curbs production of interleukin-22 by human peripheral blood mononuclear cells exposed to live Borrelia burgdorferi (2015) (0)
The role of serum sphingolipids as potential biomarkers of non‐response to direct acting antiviral therapy in chronic hepatitis C virus infection (2022) (0)
Protein in Response to IFN-Expression and Release of IL-18 Binding (2001) (0)
Hydrogen Sulfide Modulates Endothelial–Mesenchymal Transition in Heart Failure (2022) (0)
Additional Mode of Action? Fingolimod Inhibits the IL-33 Induced IFN-γ Formation in CD8+ and Affects the Formation of Bioactive Sphingolipids in Patients with Multiple Sclerosis (P5.291) (2016) (0)
P 05 . 03 BCA-1 / CXCL 13 Expression Is Associated with CXCR 5 Positive B Cell Cluster Formation in Acute Renal Transplant Rejection (2004) (0)
Opposite role for the chemokines CCL5 (RANTES) and CXCL3 (IP-10) in the development of autoimmune liver disease in the CYP2D6 mouse model (2013) (0)
P582 Insights on the sphingolipid profile in patients with short bowel syndrome and consecutive intestinal failure (2021) (0)
[A short summary. The history of glucocorticoids]. (2003) (0)
P564L-cystathionine metabolism by cystathionine gamma lyase generates H2S to preserve endothelial cell function and decelerate atherosclerosis development in humans (2018) (0)
Immunomodulation via TLR3/IRF3 by misplaced U1-snRNA as detected in human A549 lung epithelial cells (2009) (0)
Role of protein kinase C in homologous desensitization of angiotensin II-induced phosphoinositide hydrolysis in rat renal mesangial cells (1988) (0)
Keratinocyte-derived VEGF biosynthesis represents a pleiotropic side effect of PPAR γ agonist troglitazone but not rosiglitazone and involves activation of p 38 MAPK : implications for diabetes-impaired skin repair (2008) (0)
Spatiotemporal dynamics of brain activation in multiple sclerosis patients and healthy control subjects : A TMS-EEG study (2014) (0)
Risk perception and influenza vaccination coverage among medical and dental students (2009) (0)
Induction of hepatic fibrosis by an adenovirus encoding the human liver autoantigen cytochrome P450 2D6 (2013) (0)
Vasoconstrictor stimulated polyphosphoinositide metabolism and prostaglandin synthesis in renal mesangial cells (1986) (0)
Chapter 5 Pathogenesis of Renal Diseases: Renal Cell Response to Injury (2007) (0)
Matrix‐metabolizing enzymes as prime targets of redox regulation by nitric oxide (2004) (0)
Loss of S1P Lyase Expression in Human Podocytes Causes a Reduction in Nephrin Expression That Involves PKCδ Activation (2023) (0)
P110 Identification of the tryptophan metabolite 3-hydroxyanthranilic acid as a novel tool for the differentiation of Crohn’s disease phenotypes (2020) (0)
ROS-independent regulation of TLR9-induced IL-12p70 by Ncf in murine dendritic cells (2008) (0)
Possible role of protein kinase C-c isoenzyme in inhibition of interleukin 1, induction of nitric oxide synthase in rat renal mesangial cells (2005) (0)
Co-ordinate Expression of GTP Cyclohydrolase I and Inducible Nitric Oxide Synthase in Rat Mesangial Cells (1995) (0)
ResearchADAM 10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases (2015) (0)
Short communication IL-18BPa:Fc cooperates with immunosuppressive drugs in human whole blood (2003) (0)
P0335 : Serum long chain ceramides, sphingosine and sphingosine-1-phosphate as novel diagnostic markers in patients with hepatocellular carcinoma (2015) (0)
Subject Index Vol. 37, 2005 (2005) (0)
Availability in Inflammatory Macrophages Oxide Synthase by IL-13 and Arginine Translational Control of Inducible Nitric (2003) (0)
The Sphingosine Kinase-1 Activator, K6PC-5, Attenuates the Ebola Virus Infection and the Virus Induced Cell Death (2020) (0)
In dendritic cells Toll-like receptor-dependent induction of IL-12p70 is accompanied by a profound down regulation of sphingosine-1-phosphate lyase mRNA (P1348) (2013) (0)
Inhibition of polyphosphoinositide breakdown and prostaglandin synthesis in rat mesangial cells by islet-activating protein (1986) (0)
Protein kinase C isoenzymes in the rat retina: Immunocharacterization of calcium independent subtypes (1992) (0)
Activation-induced cell death in GM-CSF differentiated dendritic cells is dependent on Sphingosine kinase 1 (2016) (0)
Expression of PKM2 in wound keratinocytes is coupled to angiogenesis during skin repair in vivo and in HaCaT keratinocytes in vitro (2023) (0)
Cross-Regulation of the Cellular Redox System, Oxygen, and Sphingolipid Signalling (2023) (0)
Cytokine production by leukocytes of Papillon–Lefèvre syndrome patients in whole blood cultures (2011) (0)
Lipid signalling - Ample opportunitites for novel drug targets (2009) (0)
Nitric oxide mediates prolyl hydroxylase 3 expression in mesangial cells and in glomerulonephritis (2017) (0)
Lymphocyte Activation of CXCL12-Mediated Memory T CXCL9 Causes Heterologous Desensitization (2013) (0)
Tyrosine Phosphatase Inhibition by Nitric Oxide: The Role of Cyclic GMP and Mitogen-Activated Protein Kinase Activation Rapid and Delayed p42/p44 (1998) (0)
Lipid mediators in redox signaling (2006) (0)
Contents, Vol. 64,1993 (1993) (0)
Proteomic Analysis of Mesangial Cells (2009) (0)
Acknowledgement to Referees (1999) (0)
Role of Phospholipases A2 Inflammation (1999) (0)
Dendritic cells as key regulators in inflammation exhibit differential and sequential regulation of interleukin-23 subunit expression (2007) (0)
Contents Vol. 37, 2005 (2005) (0)
Transforming growth factor-b 2 inhibits interleukin 1b-induced expression of inducible nitric oxide synthase in rat renal mesangial cells (1997) (0)
FTY720 and two novel butterfly derivatives exert a general anti-inflammatory potential by reducing immune cell adhesion to endothelial cells through activation of S1P3 and phosphoinositide 3-kinase (2015) (0)
No activates TIMP-1 expression in glomerular mesangial cells via activation of TGFbeta-SMAD signaling cascades (2004) (0)
P075 Inflammation-induced cancer vs. cancer-induced inflammation is dependent on S1P lyase (2018) (0)
Relevance of leptin for cutaneous wound healing (2008) (0)
REVIEW INDUCIBLE NO SYNTHASE: ROLE IN CELLULAR SIGNALLING (1999) (0)
The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions (2022) (0)
Kinase Pathways Activation of the Mitogen-Activated Protein B and Activating Protein-1 and Involves κ NF-Cells Is Mediated by Increased Activities of Superoxide in Rat Glomerular Mesangial Metalloproteinase-9 Expression by-Induced Matrix β Amplification of IL-1 (2000) (0)
Sphingosine kinase 2 induces angiogenic effects by enhancing neovascularisation in the mouse model of retinopathy of prematurity (2016) (0)
P56. Cytokines and NO upregulate prolyl hydroxylase 3 (PHD-3) mRNA and protein expression in rat renal mesangial cells (2008) (0)
Contribution of group II phospholipase A2 to arachidonic acid release and prostaglandin synthesis by mesangial cells (1994) (0)
Overexpression of endothelial cell Cystathionine Gamma Lyase preserves cardiovascular function in heart failure with preserved ejection fraction (2022) (0)
[intracellular signal transmission]. (1991) (0)
The E3 Ligase TRIM25 Impairs Apoptotic Cell Death in Colon Carcinoma Cells via Destabilization of Caspase-7 mRNA: A Possible Role of hnRNPH1 (2023) (0)
Exogenous phospholipases A2 mediate gene expression in rat mesangial cells via PPARalpha activation (2002) (0)
Transforming growth factor 2 differentially modulates interleukin-ll-and tumour-necrosis-factor-x-stimulated phospholipase A 2 and prostaglandin E 2 synthesis in rat renal mesangial cells (2005) (0)
Corrigendum to “Identification of the LIM kinase-1 as a ceramide-regulated gene in renal mesangial cells” [Biochem. Biophys. Res. Commun. 298 (2002) 408–413] (2005) (0)
Differential expression of CD8 defines phenotypically distinct cytotoxic T cells in cancer and multiple sclerosis (2022) (0)
Erratum: Tristetraprolin regulation of interleukin-22 production (2015) (0)
NOVEL OXAZOLO-OXAZOLE DERIVATIVES OF FINGOLIMOD INDUCE LYMPHOPENIA AND REDUCE SYMPTOMS OF EAE IN MICE (2018) (0)
Regulation of Ciap1 and Xiap Expression by Nitric Oxide, Cytokines, and Its Relation to Apotosis Induction in Rat Mesangial Cells and Raw 264.7 Macrophages (2001) (0)
Platelet-derived growth factor and fibroblast growth factor differentially regulate interleukin 1beta- and cAMP-induced group II phospholipase A2 expression in rat renal mesangial cells. (1998) (0)
PKC-mediated Regulation of GTP Cyclohydrolase I in Mast Cells and Renal Mesangial Cells (2002) (0)
Enhanced expression of carnitine palmitoyl transferase-Ia in rat mesangial cells by exogenous secreted phospholipaseA2-IIA (2004) (0)

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Ludwig Maximilian University of Munich
University of Basel

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