Joseph Schlessinger

Joseph Schlessinger's AcademicInfluence.com Rankings

Joseph Schlessinger

Biology

#596

World Rank

#1052

Historical Rank

Cell Biology

#16

World Rank

#17

Historical Rank

Neuroscience

#86

World Rank

#91

Historical Rank

Biochemistry

#78

World Rank

#104

Historical Rank

biology Degrees

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Biology

Joseph Schlessinger's Degrees

PhD Biochemistry Weizmann Institute of Science

Why Is Joseph Schlessinger Influential?

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According to Wikipedia, Joseph Schlessinger is a Yugoslav-born Israeli-American biochemist and biophysician. He is chair of the Pharmacology Department at Yale University School of Medicine in New Haven, Connecticut, as well as the founding director of the school's new Cancer Biology Institute. His area of research is signaling through tyrosine phosphorylation, which is important in many areas of cellular regulation, especially growth control and cancer. Schlessinger's work has led to an understanding of the mechanism of transmembrane signaling by receptor tyrosine kinases and how the resulting signals control cell growth and differentiation.

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Joseph Schlessinger's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Signal transduction by receptors with tyrosine kinase activity (1990) (5143)
Cell Signaling by Receptor Tyrosine Kinases (2000) (4184)
Cell Signaling by Receptor Tyrosine Kinases (2000) (3845)
Mobility measurement by analysis of fluorescence photobleaching recovery kinetics. (1976) (2461)
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells (1984) (2426)
Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences (1984) (2385)
Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. (1985) (1878)
Cellular signaling by fibroblast growth factor receptors. (2005) (1797)
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma (2010) (1645)
Human proto‐oncogene c‐kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. (1987) (1557)
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling (1992) (1546)
Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin (1985) (1523)
Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions (1995) (1426)
Growth factor signaling by receptor tyrosine kinases (1992) (1395)
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity (2008) (1267)
Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. (1997) (1137)
Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. (2000) (1107)
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma (2012) (1047)
A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation (1996) (1027)
Ligand-Induced, Receptor-Mediated Dimerization and Activation of EGF Receptor (2002) (960)
Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases (1992) (934)
Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation. (1992) (917)
Catalytic specificity of protein-tyrosine kinases is critical for selective signalling (1995) (916)
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling (1993) (897)
A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway (1997) (876)
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. (1993) (734)
BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein (1993) (679)
Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells. (1987) (638)
Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation (1994) (637)
Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: prognostic significance of erbB-2 protein overexpression in primary breast cancer. (1990) (623)
Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction. (1992) (612)
EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling (1989) (609)
Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells (1987) (604)
The function of GRB2 in linking the insulin receptor to Ras signaling pathways. (1993) (601)
Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain (1995) (599)
Absence of marginal zone B cells in Pyk-2–deficient mice defines their role in the humoral response (2000) (588)
Structural Basis for FGF Receptor Dimerization and Activation (1999) (581)
Cloning and expression of two distinct high‐affinity receptors cross‐reacting with acidic and basic fibroblast growth factors. (1990) (571)
Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain. (1995) (563)
PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254 (1991) (553)
Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor. (1987) (550)
Activation of phospholipase Cγ by PI 3‐kinase‐induced PH domain‐mediated membrane targeting (1998) (548)
A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos (1993) (526)
Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells. (1978) (521)
Regulation of signal transduction and signal diversity by receptor oligomerization. (1994) (520)
Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras (1993) (516)
SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors. (2000) (505)
A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase (1994) (504)
Regulation of growth factor activation by proteoglycans: What is the role of the low affinity receptors? (1995) (497)
Expression of epidermal growth factor receptors in human brain tumors. (1984) (491)
Spatial control of EGF receptor activation by reversible dimerization on living cells (2010) (490)
Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases (1991) (487)
Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor (1994) (480)
Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain (1998) (474)
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway (1994) (465)
PH Domains: Diverse Sequences with a Common Fold Recruit Signaling Molecules to the Cell Surface (1996) (463)
IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. (1992) (460)
Dynamics of fluorescence marker concentration as a probe of mobility. (1976) (452)
Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body (1990) (442)
SH2/SH3 signaling proteins. (1994) (442)
A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1 (1991) (439)
Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation. (1987) (435)
Common and Distinct Elements in Cellular Signaling via EGF and FGF Receptors (2004) (435)
Signal Transduction Due to HIV-1 Envelope Interactions with Chemokine Receptors CXCR4 or CCR5 (1997) (421)
Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis (1992) (416)
Switching Signals On or Off by Receptor Dimerization (1998) (416)
The carbonic anhydrase domain of receptor tyrosine phosphatase β is a functional ligand for the axonal cell recognition molecule contactin (1995) (413)
Identification of a novel contactin‐associated transmembrane receptor with multiple domains implicated in protein–protein interactions (1997) (407)
Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction (1996) (400)
How receptor tyrosine kinases activate Ras. (1993) (400)
Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer. (2017) (397)
Lateral motion of fluorescently labeled acetylcholine receptors in membranes of developing muscle fibers. (1976) (388)
Crystal Structures of Two FGF-FGFR Complexes Reveal the Determinants of Ligand-Receptor Specificity (2000) (387)
Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing (1987) (385)
Signal transduction by allosteric receptor oligomerization. (1988) (370)
Two EGF molecules contribute additively to stabilization of the EGFR dimer (1997) (364)
A Novel Positive Feedback Loop Mediated by the Docking Protein Gab1 and Phosphatidylinositol 3-Kinase in Epidermal Growth Factor Receptor Signaling (2000) (364)
FRS2 Proteins Recruit Intracellular Signaling Pathways by Binding to Diverse Targets on Fibroblast Growth Factor and Nerve Growth Factor Receptors (2000) (361)
Structure of the FGF Receptor Tyrosine Kinase Domain Reveals a Novel Autoinhibitory Mechanism (1996) (360)
Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines. (1988) (357)
SH2 and PTB Domains in Tyrosine Kinase Signaling (2003) (344)
The EGFR family: not so prototypical receptor tyrosine kinases. (2014) (341)
Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs (1992) (338)
Interferon-induced nuclear signalling by Jak protein tyrosine kinases (1993) (335)
Structural basis for the activity of drugs that inhibit phosphodiesterases. (2004) (335)
Collection of insulin, EGF and α 2-Macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization (1978) (330)
Structural Basis for Activation of the Receptor Tyrosine Kinase KIT by Stem Cell Factor (2007) (328)
The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential. (1995) (328)
Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins (2001) (326)
Structure of a heparin-linked biologically active dimer of fibroblast growth factor (1998) (324)
Binding of Shp2 Tyrosine Phosphatase to FRS2 Is Essential for Fibroblast Growth Factor-Induced PC12 Cell Differentiation (1998) (324)
Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation. (1993) (320)
Autoregulatory Mechanisms in Protein-tyrosine Kinases* (1998) (311)
Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas (2015) (309)
SH3 domains direct cellular localization of signaling molecules (1993) (308)
The EGF Receptor Provides an Essential Survival Signal for SOS-Dependent Skin Tumor Development (2000) (308)
Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma. (1994) (301)
Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors (1992) (301)
Allosteric regulation of the epidermal growth factor receptor kinase (1986) (298)
Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration (2003) (293)
New Roles for Src Kinases in Control of Cell Survival and Angiogenesis (2000) (292)
The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1 (1996) (291)
Identification of Trk binding sites for SHC and phosphatidylinositol 3'-kinase and formation of a multimeric signaling complex. (1993) (290)
Critical role for the docking-protein FRS2α in FGF receptor-mediated signal transduction pathways (2001) (284)
Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase (1993) (282)
SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high‐affinity binding site for SH2 domains of phospholipase C gamma. (1992) (276)
A putative molecular-activation switch in the transmembrane domain of erbB2 (2002) (273)
Epidermal Growth Factor Receptor Dimerization and Activation Require Ligand-Induced Conformational Changes in the Dimer Interface (2005) (272)
Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85 (1993) (270)
Biological role of epidermal growth factor-receptor clustering. Investigation with monoclonal anti-receptor antibodies. (1983) (270)
Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation. (1989) (267)
Crystal structure at 2.2 Å resolution of the pleckstrin homology domain from human dynamin (1994) (266)
A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases. (2004) (262)
Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma (2013) (260)
Activation of Pyk2 by Stress Signals and Coupling with JNK Signaling Pathway (1996) (259)
BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers. (1991) (256)
The epidermal growth factor receptor as a multifunctional allosteric protein. (1988) (253)
Identification of the binding site for acidic phospholipids on the pH domain of dynamin: implications for stimulation of GTPase activity. (1996) (253)
Efficacy of antibodies to epidermal growth factor receptor against KB carcinoma in vitro and in nude mice. (1988) (252)
Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor (1996) (248)
Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbb protein (1985) (247)
The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC‐gamma. (1990) (246)
Signal transduction by the α6β4 integrin: distinct β4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes (1995) (246)
Lateral transport on cell membranes: mobility of concanavalin A receptors on myoblasts. (1976) (245)
Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal. (1995) (239)
Receptor tyrosine kinases: legacy of the first two decades. (2014) (235)
Local aggregation of hormone–receptor complexes is required for activation by epidermal growth factor (1979) (234)
Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction. (2006) (232)
Scanning electron microscopy of cells and tissues under fully hydrated conditions. (2004) (229)
PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation (1994) (224)
Role of IRS-1-GRB-2 complexes in insulin signaling (1994) (224)
Lateral transport of a lipid probe and labeled proteins on a cell membrane. (1977) (221)
Src and Pyk2 Mediate G-protein-coupled Receptor Activation of Epidermal Growth Factor Receptor (EGFR) but Are Not Required for Coupling to the Mitogen-activated Protein (MAP) Kinase Signaling Cascade* (2001) (220)
A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization (1991) (219)
Regulation of cell proliferation by epidermal growth factor. (1983) (218)
Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2−/− mice (2007) (217)
Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic binding (1994) (215)
Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor. (1986) (213)
Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells. (1993) (209)
Mobility of microinjected rhodamine actin within living chicken gizzard cells determined by fluorescence photobleaching recovery (1982) (208)
Annexin I is phosphorylated in the multivesicular body during the processing of the epidermal growth factor receptor (1993) (206)
GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation (1994) (206)
Signal transduction through the EGF receptor transfected in IL-3-dependent hematopoietic cells. (1988) (202)
Tyrosine Phosphorylation of the c-cbl Proto-oncogene Protein Product and Association with Epidermal Growth Factor (EGF) Receptor upon EGF Stimulation (*) (1995) (199)
Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB‐2 protein in the mammary tumor cell line SK‐BR‐3. (1988) (199)
Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase (1990) (199)
Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities (2014) (198)
A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design (2005) (197)
Activation of the JNK pathway is essential for transformation by the Met oncogene (1997) (195)
Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity. (2004) (193)
Demonstration of epidermal growth factor-induced receptor dimerization in living cells using a chemical covalent cross-linking agent. (1988) (193)
Differential signalling potential of insulin‐ and IGF‐1‐receptor cytoplasmic domains. (1989) (191)
Mutations in different components of FGF signaling in LADD syndrome (2006) (190)
Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor (1993) (185)
FRS2α attenuates FGF receptor signaling by Grb2- mediated recruitment of the ubiquitin ligase Cbl (2002) (183)
The Drosophila EGF receptor gene homolog: Conservation of both hormone binding and kinase domains (1985) (183)
Ligand‐induced transphosphorylation between different FGF receptors. (1991) (182)
The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway (2004) (182)
Functional analysis of the ligand binding site of EGF‐receptor utilizing chimeric chicken/human receptor molecules. (1989) (181)
Tyrosine 785 is a major determinant of Trk‐‐substrate interaction. (1993) (181)
Receptor tyrosine phosphatase beta is expressed in the form of proteoglycan and binds to the extracellular matrix protein tenascin. (1994) (179)
Reconstitution of human epidermal growth factor receptors and its deletion mutants in cultured hamster cells. (1986) (179)
Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. (1994) (178)
Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. (1990) (178)
Interaction between major histocompatibility complex antigens and epidermal growth factor receptors on human cells (1984) (175)
Identification of a New Pyk2 Target Protein with Arf-GAP Activity (1999) (174)
Induction of Neurite Outgrowth through Contactin and Nr-CAM by Extracellular Regions of Glial Receptor Tyrosine Phosphatase β (1997) (174)
Tyrosine Phosphorylation of Pyk2 Is Selectively Regulated by Fyn During TCR Signaling (1997) (173)
SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange (1993) (173)
The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors (1992) (171)
A point mutation at the ATP‐binding site of the EGF‐receptor abolishes signal transduction. (1988) (170)
Epidermal growth factor induces electrically silent Na+ influx in human fibroblasts. (1982) (170)
Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG). (1989) (169)
Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting. (1998) (167)
High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains. (1992) (165)
All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor. (1989) (164)
Sequence‐specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain (1997) (161)
A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis (1987) (160)
Cloning and expression of a widely expressed receptor tyrosine phosphatase. (1990) (160)
Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells, and differential binding of EGF and transforming growth factor alpha (1988) (159)
Fibronectin delays the fusion of L6 myoblasts. (1979) (159)
Monoclonal antibodies against receptor for epidermal growth factor induce early and delayed effects of epidermal growth factor. (1981) (158)
Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane (2012) (157)
Specific phosphopeptide binding regulates a conformational change in the PI 3‐kinase SH2 domain associated with enzyme activation. (1993) (155)
The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors. (2002) (153)
Sporadic amplification of the HER2/neu protooncogene in adenocarcinomas of various tissues. (1988) (153)
Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial–mesenchymal transition (2016) (151)
The Selectivity of Receptor Tyrosine Kinase Signaling Is Controlled by a Secondary SH2 Domain Binding Site (2009) (146)
Identification of a New Pyk2 Isoform Implicated in Chemokine and Antigen Receptor Signaling* (1998) (146)
Docking Protein FRS2 Links the Protein Tyrosine Kinase RET and Its Oncogenic Forms with the Mitogen-Activated Protein Kinase Signaling Cascade (2001) (145)
Anti-epidermal growth factor receptor antibodies inhibit the autocrine-stimulated growth of MDA-468 human breast cancer cells. (1989) (145)
RAC1P29S is a spontaneously activating cancer-associated GTPase (2013) (145)
Evidence that autophosphorylation of solubilized receptors for epidermal growth factor is mediated by intermolecular cross-phosphorylation. (1989) (143)
Phosphatidylinositol 3-kinase p85 SH2 domain specificity defined by direct phosphopeptide/SH2 domain binding. (1993) (143)
Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I. (1994) (143)
Localization of the epidermal growth factor (EGF) receptor within the endosome of EGF-stimulated epidermoid carcinoma (A431) cells (1986) (143)
Differential activities of protein tyrosine phosphatases in intact cells. (1993) (142)
Epidermal growth factor induces redistribution of actin and alpha-actinin in human epidermal carcinoma cells. (1981) (142)
Identification of a Novel Family of Targets of PYK2 Related to Drosophila Retinal Degeneration B (rdgB) Protein (1999) (142)
Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor (1990) (141)
Tumor necrosis factor-induced activation and increased tyrosine phosphorylation of mitogen-activated protein (MAP) kinase in human fibroblasts. (1993) (140)
A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions (2002) (139)
Regression of Chemotherapy-Resistant Polymerase ϵ (POLE) Ultra-Mutated and MSH6 Hyper-Mutated Endometrial Tumors with Nivolumab (2016) (138)
An angiogenic growth factor is expressed in human glioma cells. (1987) (138)
Dynamin binds to SH3 domains of phospholipase C gamma and GRB-2. (1994) (137)
On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors. (1987) (137)
Anti-oncogenic activity of signalling-defective epidermal growth factor receptor mutants (1992) (137)
The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor (1995) (137)
Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway (1997) (136)
Effect of phospholipase C-gamma overexpression on PDGF-induced second messengers and mitogenesis. (1990) (136)
Cloning and characterization of R-PTP-kappa, a new member of the receptor protein tyrosine phosphatase family with a proteolytically cleaved cellular adhesion molecule-like extracellular region (1993) (135)
Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation. (2000) (133)
Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling (2018) (133)
A structure-based model for ligand binding and dimerization of EGF receptors. (2004) (133)
Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domains (1997) (133)
Shc Binding to Nerve Growth Factor Receptor Is Mediated by the Phosphotyrosine Interaction Domain (*) (1995) (132)
The Precise Sequence of FGF Receptor Autophosphorylation Is Kinetically Driven and Is Disrupted by Oncogenic Mutations (2009) (132)
Real-time measurements of kinetics of EGF binding to soluble EGF receptor monomers and dimers support the dimerization model for receptor activation. (1993) (132)
High-affinity epidermal growth factor binding is specifically reduced by a monoclonal antibody, and appears necessary for early responses (1990) (131)
Whole-exome sequencing characterizes the landscape of somatic mutations and copy number alterations in adrenocortical carcinoma. (2015) (131)
Rotational diffusion of epidermal growth factor complexed to cell surface receptors reflects rapid microaggregation and endocytosis of occupied receptors. (1981) (131)
Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase β (1998) (130)
Protein tyrosine kinase Pyk2 mediates the Jak‐dependent activation of MAPK and Stat1 in IFN‐γ, but not IFN‐α, signaling (1999) (128)
Mutations in the cytoplasmic domain of EGF receptor affect EGF binding and receptor internalization. (1986) (128)
Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes (1996) (128)
Insulin and insulin-like growth factor-1 binding specificity is determined by distinct regions of their cognate receptors. (1991) (126)
Early and multiple origins of metastatic lineages within primary tumors (2016) (126)
Expression of acidic fibroblast growth factor cDNA confers growth advantage and tumorigenesis to Swiss 3T3 cells. (1988) (125)
HER2 cytoplasmic domain generates normal mitogenic and transforming signals in a chimeric receptor. (1989) (122)
Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766. (1994) (122)
Lateral motion and valence of Fc receptors on rat peritoneal mast cells (1976) (122)
Novel recognition mode between Vav and Grb2 SH3 domains (2001) (121)
Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation (1994) (121)
Mobility, clustering, and transport of nerve growth factor in embryonal sensory cells and in a sympathetic neuronal cell line. (1980) (120)
A chimaeric receptor allows insulin to stimulate tyrosine kinase activity of epidermal growth factor receptor (1986) (119)
Chimeric NGF-EGF receptors define domains responsible for neuronal differentiation. (1991) (119)
Quantitative determination of the lateral diffusion coefficients of the hormone-receptor complexes of insulin and epidermal growth factor on the plasma membrane of cultured fibroblasts. (1978) (119)
Onset of endogenous synthesis of epidermal growth factor in neonatal mice. (1987) (119)
Ligand activation of overexpressed epidermal growth factor receptors transforms NIH 3T3 mouse fibroblasts. (1988) (118)
The biochemical response of the heart to hypertension and exercise. (2004) (118)
The mechanism and role of hormone-induced clustering of membrane receptors (1980) (118)
Kit Receptor Dimerization Is Driven by Bivalent Binding of Stem Cell Factor* (1997) (118)
Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells (1990) (118)
A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers (2018) (116)
Localization of a major receptor-binding domain for epidermal growth factor by affinity labeling (1988) (114)
On the nature of low- and high-affinity EGF receptors on living cells. (2006) (113)
The catalytic activity of the CD45 membrane‐proximal phosphatase domain is required for TCR signaling and regulation. (1994) (113)
The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function. (2004) (111)
Biologically active synthetic fragments of epidermal growth factor: localization of a major receptor-binding region. (1984) (110)
Multi-ligand interactions with receptor-like protein tyrosine phosphatase beta: implications for intercellular signaling. (1998) (110)
Signaling-competent receptor chimeras allow mapping of major insulin receptor binding domain determinants. (1993) (108)
Trans-activation of EphA4 and FGF receptors mediated by direct interactions between their cytoplasmic domains. (2005) (108)
Truncation of the human EGF receptor leads to differential transforming potentials in primary avian fibroblasts and erythroblasts. (1988) (107)
Stabilization of an active dimeric form of the epidermal growth factor receptor by introduction of an inter-receptor disulfide bond. (1994) (105)
Kinetics of binding, endocytosis, and recycling of EGF receptor mutants (1992) (105)
Asymmetric tyrosine kinase arrangements in activation or autophosphorylation of receptor tyrosine kinases (2010) (104)
Exome sequencing identifies recurrent somatic RAC 1 mutations in melanoma (2016) (103)
Activation of Ras and other signaling pathways by receptor tyrosine kinases. (1994) (103)
Data publication with the structural biology data grid supports live analysis (2016) (103)
Reduced Activation of RAF-1 and MAP Kinase by a Fibroblast Growth Factor Receptor Mutant Deficient in Stimulation of Phosphatidylinositol Hydrolysis (*) (1995) (103)
Fc epsilon R1-mediated tyrosine phosphorylation of multiple proteins, including phospholipase C gamma 1 and the receptor beta gamma 2 complex, in RBL-2H3 rat basophilic leukemia cells (1992) (103)
Attenuation of signaling pathways stimulated by pathologically activated FGF-receptor 2 mutants prevents craniosynostosis (2006) (101)
Epidermal growth factor (EGF) stimulates association and kinase activity of Raf-1 with the EGF receptor. (1991) (99)
Autoinhibition Control (2003) (99)
Three forms of RPTP‐β are differentially expressed during gliogenesis in the developing rat brain and during glial cell differentiation in culture (1996) (99)
No Obvious Abnormality in Mice Deficient in Receptor Protein Tyrosine Phosphatase β (2000) (98)
The expression of a novel receptor-type tyrosine phosphatase suggests a role in morphogenesis and plasticity of the nervous system. (1993) (98)
Fluorescent labeling of hormone receptors in viable cells: preparation and properties of highly fluorescent derivatives of epidermal growth factor and insulin. (1978) (98)
Activation of the nonreceptor protein tyrosine kinase Ack by multiple extracellular stimuli. (2006) (98)
A novel receptor tyrosine phosphatase-sigma that is highly expressed in the nervous system. (1993) (98)
Kinetic parameters of the protein tyrosine kinase activity of EGF‐receptor mutants with individually altered autophosphorylation sites. (1988) (97)
Novel signaling pathway suggested by SH3 domain-mediated p95vav/heterogeneous ribonucleoprotein K interaction. (1994) (97)
Phospholipase C‐gamma, a substrate for PDGF receptor kinase, is not phosphorylated on tyrosine during the mitogenic response to CSF‐1. (1989) (97)
Biological activities of EGF‐receptor mutants with individually altered autophosphorylation sites. (1988) (96)
Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand–receptor interactions (2015) (96)
Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling (2010) (96)
Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses. (1992) (95)
Crystal structure of the ARF‐GAP domain and ankyrin repeats of PYK2‐associated protein β (1999) (95)
EGF induces increased ligand binding affinity and dimerization of soluble epidermal growth factor (EGF) receptor extracellular domain. (1991) (94)
Nuclear Signaling by Receptor Tyrosine Kinases: The First Robin of Spring (2006) (93)
Solution structure of the SH3 domain of phospholipase C-γ (1993) (93)
The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis (1996) (93)
Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells. (1994) (92)
Structure of the N-terminal SH3 domain of GRB2 complexed with a peptide from the guanine nucleotide releasing factor Sos (1994) (92)
'Tuning' of type I interferon–induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages (2008) (91)
Antigen-induced conformational changes in antibodies and their Fab fragments studied by circular polarization of fluorescence. (1975) (90)
Induction of cell attachment and morphological differentiation in a pheochromocytoma cell line and embryonal sensory cells by the extracellular matrix. (1982) (89)
Lateral diffusion of epidermal growth factor complexed to its surface receptors does not account for the thermal sensitivity of patch formation and endocytosis. (1982) (89)
The Dark Side of Cell Signaling: Positive Roles for Negative Regulators (2016) (89)
Mobility and distribution of a cell surface glycoprotein and its interaction with other membrane components. (1977) (89)
FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic–pituitary–adrenal axis (2015) (88)
The tyrosine kinase activity of the epidermal-growth-factor receptor is necessary for phospholipase A2 activation. (1990) (88)
Direct Binding and Activation of Receptor Tyrosine Kinases by Collagen (1997) (88)
Large deletions in the cytoplasmic kinase domain of the epidermal growth factor receptor do not affect its laternal mobility (1986) (88)
A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog (1996) (87)
Design of protein-binding proteins from the target structure alone (2022) (85)
Disulfide Bond Structure of Human Epidermal Growth Factor Receptor* (1998) (85)
Lateral diffusion of surface immunoglobulin, Thy-1 antigen, and a lipid probe in lymphocyte plasma membranes. (1979) (85)
Identification of the bombesin-receptor on murine and human cells by cross-linking experiments (1987) (85)
Solution structure of pleckstrin homology domain of dynamin by heteronuclear NMR spectroscopy. (1995) (85)
Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina. (2004) (82)
Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. (1995) (82)
Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway. (1998) (81)
Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization (2008) (81)
Epidermal growth factor (EGF) induces oligomerization of soluble, extracellular, ligand-binding domain of EGF receptor. A low resolution projection structure of the ligand-binding domain. (1991) (81)
Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate (2012) (80)
Human HER2 (neu) promoter: evidence for multiple mechanisms for transcriptional initiation (1987) (80)
The Docking Protein Gab1 Is an Essential Component of an Indirect Mechanism for Fibroblast Growth Factor Stimulation of the Phosphatidylinositol 3-Kinase/Akt Antiapoptotic Pathway (2004) (80)
Purification of an active EGF receptor kinase with monoclonal antireceptor antibodies. (1985) (80)
Receptor diffusion on cell surfaces modulated by locally bound concanavalin A. (1977) (79)
Molecular basis of negative co-operativity in rabbit muscle glyceraldehyde-3-phosphate dehydrogenase. (1974) (79)
Identification of autophosphorylation sites of HER2/neu. (1990) (78)
Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors. (1989) (77)
Specific role for the PH domain of dynamin‐1 in the regulation of rapid endocytosis in adrenal chromaffin cells (1997) (77)
Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK (2015) (76)
Mutation profiles in early-stage lung squamous cell carcinoma with clinical follow-up and correlation with markers of immune function (2016) (75)
Homogeneity and variability in the structure of azurin molecules studied by fluorescence decay and circular polarization. (1975) (74)
Amplification and Overexpression of the EGF Receptor Gene in Primary Human Glioblastomas (1985) (74)
Stoichiometry, Kinetic and Binding Analysis of the Interaction between Epidermal Growth Factor (EGF) and the Extracellular Domain of the EGF Receptor (2000) (74)
The Docking Protein FRS2α Is an Essential Component of Multiple Fibroblast Growth Factor Responses during Early Mouse Development (2005) (74)
Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up (2017) (73)
Separate endocytic pathways of kinase-defective and -active EGF receptor mutants expressed in same cells (1990) (73)
Ligand-induced stimulation of epidermal growth factor receptor mutants with altered transmembrane regions. (1988) (73)
Incorporation of fluorescent gangliosides into human fibroblasts: mobility, fate, and interaction with fibronectin (1984) (72)
Lateral diffusion of membrane lipids and proteins during the cell cycle of neuroblastoma cells. (1980) (72)
Stimulation of receptor protein-tyrosine phosphatase alpha activity and phosphorylation by phorbol ester. (1995) (72)
Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2. (1994) (72)
Activation of the c-fos serum response element by phosphatidyl inositol 3-kinase and rho pathways in HeLa cells. (1998) (70)
Diffusion and patching of macromolecules on planar lipid bilayer membranes. (1977) (69)
FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial‐temporal patterns of expression of their transcripts (2004) (69)
Five enzymes of the glycolytic pathway serve as substrates for purified epidermal-growth-factor-receptor kinase. (1986) (68)
Solution structure and ligand-binding site of the carboxy-terminal SH3 domain of GRB2. (1994) (68)
Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells (2010) (67)
Transphosphorylation as a possible mechanism for insulin and epidermal growth factor receptor activation. (1990) (66)
Pyk2 Is Required for Neutrophil Degranulation and Host Defense Responses to Bacterial Infection (2011) (65)
The dynamics of cytoskeletal organization in areas of cell contact. (1984) (65)
Lacrimo-Auriculo-Dento-Digital Syndrome Is Caused by Reduced Activity of the Fibroblast Growth Factor 10 (FGF10)-FGF Receptor 2 Signaling Pathway (2007) (65)
Inhibition of human tumor growth in nude mice by a conjugate of doxorubicin with monoclonal antibodies to epidermal growth factor receptor. (1989) (64)
Solution structure of the SH2 domain of Grb2 complexed with the Shc-derived phosphotyrosine-containing peptide. (1999) (64)
Release of a phorbol ester-induced mitogenic block by mutation at Thr-654 of the epidermal growth factor receptor (1988) (64)
A chimeric, ligand-binding v-erbB/EGF receptor retains transforming potential. (1987) (64)
The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5. (1993) (62)
Tyrosine phosphatase inhibition permits analysis of signal transduction complexes in p185HER2/neu-overexpressing human tumor cells. (1992) (62)
Solution structure of Grb2 reveals extensive flexibility necessary for target recognition. (2001) (62)
Scratching the surface with the PH domain (1995) (62)
Essential role of Shp2-binding sites on FRS2alpha for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells. (2005) (61)
Presence of SH2 domains of phospholipase C gamma 1 enhances substrate phosphorylation by increasing the affinity toward the epidermal growth factor receptor. (1992) (61)
Signaling by receptor tyrosine kinases : a subject collection from Cold Spring Harbor perspectives in biology (2014) (60)
Alk and Ltk ligands are essential for iridophore development in zebrafish mediated by the receptor tyrosine kinase Ltk (2017) (58)
Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta (1994) (58)
An FGF4‐FRS2α‐Cdx2 Axis in Trophoblast Stem Cells Induces Bmp4 to Regulate Proper Growth of Early Mouse Embryos (2009) (57)
An insertional mutant of epidermal growth factor receptor allows dissection of diverse receptor functions. (1987) (57)
Noncontiguous regions in the extracellular domain of EGF receptor define ligand-binding specificity. (1991) (57)
Insulin and antibodies against insulin receptor cap on the membrane of cultured human lymphocytes (1980) (57)
Aggregation-induced activation of the epidermal growth factor receptor protein tyrosine kinase. (1993) (56)
Substrate phosphorylation specificity of the human c-kit receptor tyrosine kinase. (1991) (55)
Discovery of novel fibroblast growth factor receptor 1 kinase inhibitors by structure-based virtual screening. (2010) (55)
Conformational changes induced in a homogeneous anti-type III pneumococcal antibody by oligosaccharides of increasing size. (1975) (54)
Ligand-binding enhances the affinity of dimerization of the extracellular domain of the epidermal growth factor receptor. (1997) (54)
Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3 (2007) (53)
A nonmitogenic analogue of epidermal growth factor induces early responses mediated by epidermal growth factor (1982) (53)
Variations of Proline-Rich Kinase Pyk2 Expression Correlate with Prostate Cancer Progression (2001) (52)
Multiple forms of the human tyrosine phosphatase RPTP alpha. Isozymes and differences in glycosylation. (1994) (52)
Lateral diffusion of membrane lipids and proteins is increased specifically in neurites of differentiating neuroblastoma cells. (1979) (50)
The carbohydrate specificities of the monoclonal antibodies 29.1, 445 and 3C1B12 to the epidermal growth factor receptor of A431 cells (1985) (49)
Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up. (2017) (49)
Intermolecular transphosphorylation between insulin receptors and EGF‐insulin receptor chimerae. (1989) (49)
Dynamic interactions of fluorescently labeled microtubule-associated proteins in living cells (1984) (48)
Purification and characterization of a 90 kDa protein released from human tumors and tumor cell lines (1993) (48)
Autophosphorylation mutants of the EGF-receptor signal through auxiliary mechanisms involving SH2 domain proteins. (1994) (48)
Thyrotropin induces changes in the morphology and the organization of microfilament structures in cultured thyroid cells. (1982) (48)
A non-mitogenic analogue of epidermal growth factor enhances the phosphorylation of endogenous membrane proteins. (1981) (47)
Measurement of lateral transport on cell surfaces. (1976) (47)
Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate (2010) (47)
Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling. (1999) (47)
Receptor Protein Tyrosine Phosphatase γ Is a Marker for Pyramidal Cells and Sensory Neurons in the Nervous System and Is Not Necessary for Normal Development (2006) (45)
High-affinity binding and activation of a truncated FGF receptor by both aFGF and bFGF. (1991) (45)
A 40-kDa epidermal growth factor/transforming growth factor alpha-binding domain produced by limited proteolysis of the extracellular domain of the epidermal growth factor receptor. (1993) (44)
Close Similarity between Drosophila Neurexin IV and Mammalian Caspr Protein Suggests a Conserved Mechanism for Cellular Interactions (1997) (44)
Mutational landscape of primary, metastatic, and recurrent ovarian cancer reveals c-MYC gains as potential target for BET inhibitors (2018) (44)
Ligand-independent tyrosine phosphorylation of EGF receptor and the erbB-2/neu proto-oncogene product is induced by hyperosmotic shock. (1989) (43)
Microaggregation of hormone‐occupied epidermal growth factor receptors on plasma membrane preparations. (1986) (43)
Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation (2007) (43)
Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy (2019) (43)
Cellular signaling by receptor tyrosine kinases. (1993) (42)
Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2. (2009) (41)
Solution structure of human acidic fibroblast growth factor and interaction with heparin-derived hexasaccharide (1999) (41)
Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin (2011) (40)
The structure and function of the epidermal growth factor receptor studied by using antisynthetic peptide antibodies (1985) (40)
Comparison of EGF receptor sequences as a guide to study the ligand binding site. (1991) (39)
The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development. (2005) (39)
Platelet-derived growth factor (PDGF)-induced disulfide-linked dimerization of PDGF receptor in living cells (1991) (39)
Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β–dependent mechanisms (2016) (39)
Structural diversity and binding of FGF receptors. (1991) (38)
Monoclonal antibody reactive with the human epidermal-growth-factor receptor recognizes the blood-group-A antigen (1983) (38)
Cloning and expression of the human substance K receptor and analysis of its role in mitogenesis. (1991) (37)
Characterization of the submicroscopic deletion in the small‐cell lung carcinoma (SCLC) cell line U2020 (1992) (36)
Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitro. (1995) (36)
Restricted mobility of membrane constituents in cell-substrate focal contacts of chicken fibroblasts (1982) (36)
Thermodynamic Studies of SHC Phosphotyrosine Interaction Domain Recognition of the NPXpY Motif (*) (1996) (34)
FGFR3-targeted mAb therapy for bladder cancer and multiple myeloma. (2009) (34)
Close similarity between receptor-linked tyrosine phosphatase and rat brain proteoglycan (1994) (34)
Activation of c‐erbB in avian leukosis virus‐induced erythroblastosis leads to the expression of a truncated EGF receptor kinase. (1985) (34)
Primary amines do not prevent the endocytosis of epidermal growth factor into 3T3 fibroblasts. (1981) (34)
Adenosine 3',5'-monophosphate modulates thyrotropin receptor clustering and thyrotropin activity in culture. (1981) (33)
Transmembrane signaling by receptor oligomerization. (1998) (33)
Inhibition of ErbB3 by a monoclonal antibody that locks the extracellular domain in an inactive configuration (2015) (33)
Integrated mutational landscape analysis of uterine leiomyosarcomas (2021) (33)
Mitogenic Effects of Fibroblast Growth Factors in Cultured Fibroblastsa (1991) (33)
Differential effects of W mutations on p145c-kit tyrosine kinase activity and substrate interaction. (1992) (33)
Monoclonal antibodies associated with sodium channel block nerve impulse and stain nodes of Ranvier (1984) (33)
Cooperativity in associating proteins. Monomer-dimer equilibrium coupled to ligand binding. (1974) (32)
Appearance of functional EGF receptor kinase during rodent embryogenesis. (1983) (32)
Expression of receptor protein tyrosine phosphatase‐σ (RPTP‐σ) in the nervous system of the developing and adult rat (1995) (32)
Overexpression of epidermal growth factor receptor in NIH-3T3- transfected cells slows its lateral diffusion and rate of endocytosis (1988) (31)
Indirect immunotargeting of CIS‐PT to human epidermoid carcinoma KB using the avidin‐biotin system (1991) (31)
Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders. (2017) (31)
Structure, domain organization, and different conformational states of stem cell factor-induced intact KIT dimers (2014) (31)
The binding of complement by complexes formed between a rabbit antibody and oligosaccharides of increasing size. (1976) (30)
Dependence of a human squamous carcinoma and associated paraneoplastic syndromes on the epidermal growth factor receptor pathway in nude mice. (1991) (30)
Differential effects of carboxy-terminal sequence deletions on platelet-derived growth factor receptor signaling activities and interactions with cellular substrates (1992) (29)
Subcellular distribution of the external and internal domains of the EGF receptor in A-431 cells. (1986) (29)
Epidermal growth factor receptor cytoplasmic domain mutations trigger ligand-independent transformation (1990) (29)
FRS2α Regulates Erk Levels to Control a Self-Renewal Target Hes1 and Proliferation of FGF-Responsive Neural Stem/Progenitor Cells (2010) (29)
Distinct structural specificities for functional coupling of the epidermal growth factor receptor to calcium-signalling versus phospholipase A2 responses. (1991) (28)
Induction of Urokinase-type Plasminogen Activator by Fibroblast Growth Factor (FGF)-2 Is Dependent on Expression of FGF Receptors and Does Not Require Activation of Phospholipase Cγ1* (1996) (28)
Growth Factors, Growth-Factor Receptors and Oncogenes (1985) (28)
Human Sos 1 : A Guanine Nucleotide Exchange Factor for Ras That Binds to GRB 2 (2012) (27)
Expression of ki‐ras oncogene in tumor cell variants exhibiting different metastatic capabilities (1985) (26)
Monoclonal antibodies against epidermal growth factor receptor induce prolactin synthesis in cultured rat pituitary cells (GH3). (1983) (26)
The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer. (2015) (25)
Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region (2013) (25)
Evidence for SH3 domain directed binding and phosphorylation of Sam68 by Src (1999) (24)
Vav: A potential link between tyrosine kinases and Ras‐like GTPases in hematopoietic cell signaling (1993) (24)
BEK, a receptor for multiple members of the fibroblast growth factor (FGF) family, maps to human chromosome 10q25.3----q26. (1992) (24)
The EGF receptor kinase: evidence for allosteric activation and intramolecular self-phosphorylation. (2008) (24)
Direct visualization of membrane clustering and endocytosis of thyrotropin into cultured thyroid cells (1982) (24)
Domain deletion in the extracellular portion of the EGF-receptor reduces ligand binding and impairs cell surface expression. (1990) (24)
The proto-oncogene c-Cbl is a negative regulator of DNA synthesis initiated by both receptor and cytoplasmic tyrosine kinases (1999) (24)
SU 6668 Is a Potent Antiangiogenic and Antitumor Agent That Induces Regression of Established Tumors 1 (2000) (23)
JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules. (2017) (23)
A study of subtilisin types Novo and Carlsberg by circular polarization of fluorescence. (1975) (23)
A comparative study of NAD+ binding sites in dehydrogenases by circular polarization of fluorescence. (1975) (23)
Solubilization of the receptor for the neuropeptide gastrin-releasing peptide (bombesin) with functional ligand binding properties. (1990) (23)
Structures of ligand-occupied β-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity (2019) (23)
Crk protein binds to PDGF receptor and insulin receptor substrate-1 with different modulating effects on PDGF- and insulin-dependent signaling pathways (1998) (23)
Characterization of a human recombinant receptor-linked protein tyrosine phosphatase. (1991) (23)
Modified kinetics of platelet-derived growth factor-induced Ca2+ increases in NIH-3T3 cells overexpressing phospholipase C gamma 1. (1992) (23)
SH 2 domains prevent tyrosine dephosphorylation of the EGF receptor : identification of Tyr 992 as the high-affinity binding site for SH 2 domains of phospholipase CT (23)
Antibody-hapten interactions: circular and linear polarization of the fluorescence of dansyl bound to anti-dansyl antibodies. (1974) (22)
Phosphatidylinositol 3′‐kinase associates with p145c‐kit as part of a cell type characteristic multimeric signalling complex. (1993) (22)
Analysis of platelet-derived growth factor receptor domain function using a novel chimeric receptor approach. (1991) (22)
Characterization of internalization and endosome formation of epidermal growth factor in transfected NIH-3T3 cells by computerized image- intensified three-dimensional fluorescence microscopy (1989) (21)
The docking protein FRS2α is a critical regulator of VEGF receptors signaling (2014) (20)
Signal transduction by epidermal growth factor receptor. (1988) (20)
Neuronal differentiation in response to epidermal growth factor of transfected murine P19 embryonal carcinoma cells expressing human epidermal growth factor receptors. (1991) (19)
Differential pre- and postsynaptic modulation of chemical transmission in the squid giant synapse by tyrosine phosphorylation. (1997) (19)
Protein kinases in cellular signal transduction: tyrosine kinase growth factor receptors and protein kinase C. (1986) (19)
Circular polarization of fluorescence of probes bound to chymotrypsin. Change in asymmetric environment upon electronic excitation. (1972) (19)
Surface Binding Inhibitors of the SCF–KIT Protein–Protein Interaction (2009) (18)
Optical Rotatory Power in the Ground State and Electronically Excited State of Diketopiperazines Containing Aromatic Side Chains (1974) (18)
Conformation of an Shc-derived phosphotyrosine-containing peptide complexed with the Grb2 SH2 domain (1997) (17)
Circular polarization of fluorescence of chlorophyll in solution and in native structures. (1975) (17)
Characterization of receptors for bombesin/gastrin-releasing peptide in human and murine cells. (1989) (17)
A solid base for assaying protein kinase activity (2002) (17)
Modulation of p145c-kit function in cells of patients with acute myeloblastic leukemia. (1993) (17)
Retroviral gene transfer of epidermal growth factor receptor into HL60 cells results in a partial block of retinoic acid-induced granulocytic differentiation. (1993) (16)
Generation of recombinant cytoplasmic domain of epidermal growth factor receptor with intrinsic protein tyrosine kinase activity. (1990) (16)
Phospholipase Cgamma activation and phosphoinositide hydrolysis are essential for embryonal development. (1997) (16)
Nerve growth factor acutely reduces chemical transmission by means of postsynaptic TrkA-like receptors in squid giant synapse. (1998) (16)
All signaling is local? (2002) (16)
Role of SH2-containing proteins in cellular signaling by receptor tyrosine kinases. (1992) (16)
Distinct cellular properties of oncogenic KIT receptor tyrosine kinase mutants enable alternative courses of cancer cell inhibition (2016) (16)
The dynamic interrelationships of actin and vinculin in cultured cells. (1983) (16)
The epidermal growth factor receptor as a substrate for a kinase-splitting membranal proteinase. (1988) (15)
Insulin-EGF receptor chimerae mediate tyrosine transphosphorylation and serine/threonine phosphorylation of kinase-deficient EGF receptors. (1991) (15)
High-affinity interleukin 2 binding by an oncogenic hybrid interleukin 2-epidermal growth factor receptor molecule. (1987) (15)
Lateral and rotational diffusion of EGF–receptor complex: Relationship to receptor‐mediated endocytosis (1983) (15)
Small molecule combats cancer-causing KRAS protein at last (2019) (15)
Carboxy-terminal truncations of epidermal growth factor (EGF) receptor affect diverse EGF-induced cellular responses. (1991) (15)
Mutation profiles in early-stage lung squamous cell carcinoma with clinical follow-up and correlation with markers of immune function. (2016) (15)
Inhibition of BET Bromodomain Proteins with GS-5829 and GS-626510 in Uterine Serous Carcinoma, a Biologically Aggressive Variant of Endometrial Cancer (2018) (14)
‘ In vitro and in vivo studies of a VEGF 121 / rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors (2002) (14)
Improved survival of patients with hypermutation in uterine serous carcinoma (2015) (14)
Metabolic effects induced by epidermal growth factor (EGF) in cells expressing EGF receptor mutants. (1989) (13)
Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up. (2018) (13)
Antibodies to two defined regions of the transforming protein pp60src interact specifically with the epidermal growth factor receptor kinase system. (1984) (13)
CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX (2000) (13)
Production of EGF‐containing polypeptides in Xenopus oocytes microinjected with submaxillary gland mRNA. (1984) (12)
5. Fluorescence Methods for Studying Membrane Dynamics (1982) (12)
Fluorescence and Optical Activity of Acridine Dyes Bound to Poly-A and DNA (1973) (12)
Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core. (2020) (12)
Expression of functional epidermal growth factor receptors in a human hematopoietic cell line. (1991) (12)
Structure of human epidermal growth factor receptor and expression of normal and variant mRNAs in epidermoid carcinoma cells (1985) (11)
Definition of Signals for Neuronal Differentiation (1995) (11)
Calculations of CD and CPL spectra as a tool for evaluation of the conformational differences between ground and excited states of chiral molecules (1974) (10)
Identification of a Novel 135-kDa Grb2-binding Protein in Osteoclasts* (1996) (10)
Role of FGFs and FGF Receptors in Human Carcinogenesis (1991) (10)
Monoclonal Antibodies against the Membrane Receptor for Epidermal Growth Factor: A Versatile Tool for Structural and Mechanistic Studies (1984) (10)
Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-α) (2018) (10)
Structural basis for ligand reception by anaplastic lymphoma kinase (2021) (10)
Erratum: Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up [Ann Oncol, 28, 1, (2017) (75-82)] DOI: 10.1093/annonc/mdw436 (2017) (10)
Regulation of Cell Growth by the EGF Receptor (1986) (10)
Aryl Extensions of Thienopyrimidinones as Fibroblast Growth Factor Receptor 1 Kinase Inhibitors. (2011) (9)
Folding, association, and interactions of domains in the antibody molecule. (1977) (8)
Robust de novo design of protein binding proteins from target structural information alone (2021) (8)
One bead, one chemical compound: use of the selectide process for anticancer drug discovery. (1994) (8)
Mechanism for the activation of the anaplastic lymphoma kinase receptor (2021) (8)
Novel fluorescent approaches for studying cell signaling in single cells (2000) (8)
Polypeptide-Hormone-Induced Receptor Clustering and Internalization (1983) (8)
Mutational analysis of the epidermal growth factor-receptor kinase. (1990) (8)
Cell signaling by receptor tyrosine kinases: From basic concepts to clinical applications (2006) (8)
FcERi-Mediated Tyrosine Phosphorylation ofMultiple Proteins, Including Phospholipase C-ylandtheReceptor W1Y2 Complex, inRBL-2H3RatBasophilic Leukemia Cells (1992) (8)
The genesis of Zelboraf: Targeting mutant B-Raf in melanoma (2012) (8)
DYNAMICS OF HORMONE RECEPTORS ON CELL MEMBRANE * (1981) (7)
Regulation of cell growth and transformation by the epidermal growth factor receptor. (1988) (7)
FGF23 contains two distinct high-affinity binding sites enabling bivalent interactions with α-Klotho (2020) (7)
Variation of the linear polarization across the emission band of nicotinamide 1,N6-ethenoadenine dinucleotide bound to dehydrogenases (1979) (7)
Mobilities of cell-membrane proteins: how are they modulated by the cytoskeleton? (1983) (7)
Structural analysis of the mechanism of phosphorylation of a critical autoregulatory tyrosine residue in FGFR1 kinase domain (2015) (7)
A step towards treating KRAS-mutant NSCLC. (2013) (7)
Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association (2020) (6)
Solution structure of the SH2 domain of Grb2/Ash complexed with EGF receptor-derived phosphotyrosine-containing peptide. (1999) (6)
Subunit interaction in antibodies and antibody fragments studied by circular polarization of fluorescence (1975) (6)
An FGF 4-FRS 2-Cdx 2 Axis in Trophoblast Stem Cells Induces BMP 4 to Regulate Proper Growth of Early Mouse Embryos (2009) (6)
Cloning, Expression of the Human Substance K Receptor, and Analysis of Its Role in Mitogenesis (1991) (6)
Epidermal Growth Factor Receptor Proto-Oncogene (1989) (6)
Activation of insulin-epidermal growth factor (EGF) receptor chimerae regulates EGF receptor binding affinity (1992) (6)
Epidermal growth factor-induced phosphoinositide hydrolysis in permeabilized 3T3 cells: lack of guanosine triphosphate dependence and inhibition by tyrosine-containing peptides. (1990) (6)
Use of tyrosine-phosphorylated proteins to screen bacterial expression libraries for SH2 domains. (1995) (5)
SU11248: Genesis of a new cancer drug (2005) (5)
Erratum: Signal transduction by the α6β4 integrin: Distinct β4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes (EMBO Journal (1995) 14 (4470-4481)) (2000) (5)
Interaction of Epidermal Growth Factor with Vasoactive Hormones in the Regulation of Phospholipase A2 (1991) (5)
Indoloxytriazines as binding molecules for the JAK2 JH2 pseudokinase domain and its V617F variant. (2021) (5)
Cell signaling by receptor tyrosine kinases: from bench to bedside (2007) (5)
Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands. (2022) (4)
A hypothalamic pathway for Augmentor α–controlled body weight regulation (2022) (4)
Quantitative Methods for Studying the Mobility and Distribution of Receptors on Viable Cells (1981) (4)
Binding of phosphorylcholine to an IgM Waldenström as studied by fluorescence spectroscopy and circular dichroism. (1976) (3)
Receptor Activation by Antigens, Cytokines, Hormones and Growth Factors (1995) (3)
The gene for receptor-linked protein-tyrosine-phosphatase (PTPA) is assigned to human chromosome 20p12-pter by in situ hybridization (ISH and FISH). (1992) (3)
Characterization of the detergent solubilized receptor for gastrin-releasing peptide (1990) (3)
Activation and regulation of the insulin receptor kinase. (1992) (3)
Mutational landscape of uterine and ovarian carcinosarcomas. (2016) (3)
Identification of the Bombesin Receptor on Murine and Human Cells by Cross‐Linking Experiments (1988) (3)
Nuclear magnetic resonance analysis of the conformational state of cancer mutant of fibroblast growth factor receptor 1 tyrosine kinase domain (2016) (3)
Functional EGF-receptor kinase in embryonic tissues (1983) (2)
Heterogeneity in the circular polarization of protein fluorescence [proceedings]. (1977) (2)
Tyrosine Kinase Activity IsEssential fortheAssociation of Phospholipase C-ywiththeEpidermal GrowthFactor Receptor (1990) (2)
Conversion of a False Virtual Screen Hit into Selective JAK2 JH2 Domain Binders Using Convergent Design Strategies. (2022) (2)
The ins and outs of protein phosphorylation (2000) (2)
CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2) (2000) (2)
Phosphoamino acid specificity of the EGF-receptor kinase system in normal mitogenically responsive human cells (1983) (2)
Synthetic peptide approach to the analysis of kinase activities of avian EGF receptor and v-erbB protein. (1985) (2)
Epidermal growth factor receptor proto-oncogene. Structure, evolution of properties of receptor mutants. (1989) (2)
Use of Large Combinatorial Chemical Libraries for Anticancer Drug Discovery (1995) (2)
Identiﬁcation of Six Novel Autophosphorylation Sites on Fibroblast Growth Factor Receptor 1 and Elucidation of Their Importance in Receptor Activation and Signal Transduction (1996) (2)
Production ofEGF-containing polypeptides inXenopus oocytes microinjected withsubmaxillary gland mRNA (1984) (2)
PH Domains: Diverse Sequences with Minireview a Common Fold Recruit Signaling Molecules to the Cell Surface (1996) (1)
FGFR1: FGF receptor-1 (vertebrates) (fms-like kinase, flk) (1995) (1)
Reminiscences on the "Classic" 1976 FRAP Article in Biophysical Journal. (2018) (1)
Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein (2022) (1)
The interaction of cultured thyroid cells of early bovine embryos with thyrotropin and thyroglobulin. (1982) (1)
Nerve growth factor acutely reduces chemical transmission by means of postsynaptic TrkA-like receptors in squid giant synapse (neurotrophins and neurotrophisysynaptic transmissionypresynapticyphosphorylationyautophosphorylation) (1998) (1)
STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM PHOSPHOLIPASE C DELTA IN COMPLEX WITH INOSITOL TRISPHOSPHATE (1996) (1)
Molecular steps in the action and regulation of epidermal growth factor: a cellular mitogen. (1982) (1)
Effects of Algorithmic Trend Promotion: Evidence from Coordinated Campaigns in Twitter's Trending Topics (2023) (1)
Structural and Functional Analysis of Cell Surface Receptors with Tyrosine Kinase Activity (1986) (1)
Direct Binding and Activation Minireview of Receptor Tyrosine Kinases by Collagen (1997) (1)
Author response: Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities (2014) (1)
Abstract 142: Mutation and immune profiles in early-stage lung squamous cell carcinoma (2016) (1)
Epidermal GrowthFactor (EGF)Stimulates Association andKinase Activity ofRaf-1 withtheEGF Receptor (1991) (1)
Erratum: FRS2α attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cb1 (Proceedings of the National Academy of Sciences of the United States of America (May 14, 2002) 99:10 (6684-6689)) (2002) (1)
MinireviewLigand-Induced , Receptor-Mediated Dimerization and Activation of EGF (2002) (1)
Intermolecular transphosphorylation between insulin receptors and EGF-insulin receptor chimerae (1990) (1)
JAK2 JH2 in complex with JAK067 (2020) (1)
Proceedings: Heterogenity of antibody binding sites of inbred mice as revealed by circular polarization of fluorescence. (1975) (1)
Signal transduction by EGF-receptor and its mutants (1990) (1)
HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR (1998) (1)
Abstract PL04-03: Cell signaling by receptor tyrosine kinases: From basic principles to cancer therapy (2012) (1)
the c-Jun N-terminal kinase signaling pathway . epidermal growth factor-induced activation of Phosphatidylinositol 3-kinase mediates (1997) (0)
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With 1-(2-chloro-phenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester (2005) (0)
bind identification techniques for the substances to the Pyk2 polypeptide (1997) (0)
JAK2 JH2 in complex with IKK-2 Inhibitor VI (2017) (0)
Monoclonal antibodies against the receptor of the epidermal growth factor and those containing therapeutic preparations. (1989) (0)
THE DYNAMIC PROPERTIES OF CYTOSKELETAL STRUCTURE ASSOCIATED WITH ADHAERENS JUNCTIONS IN LIVING CELLS : MICROINJECTION COMBINED WITH FLUORESCENCE PHOTOBLEACHING RECOVERY MEASUREMENTS (2004) (0)
JAK2 JH2 in complex with XMU-MP-1 (2018) (0)
Crystal structure of Fibroblast Growth Factor Receptor 1 kinase domain (2010) (0)
Monoclonal antibody specific to human epidermal growth factor receptor and therapeutic agent using the same (1989) (0)
- FGFR3: FGF receptor-3 (vertebrates) (1995) (0)
An insertional mutant of epidermal growth factor receptor allows dissection of diverse receptor functions. (1987) (0)
Science Signaling Podcast: 03 March 2009 (2009) (0)
Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1 (2004) (0)
Uterine leiomyosarcomas harboring MAP2K4 gene amplification are sensitive in vivo to PLX8725, a novel MAP2K4 inhibitor. (2023) (0)
Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Piclamilast (2004) (0)
Interferon regulatory factors (IRFs); providing the molecular link between cytokine action and host defense. (1996) (0)
Epidermal Growth Factor Receptor Autophosphorylation Is Not Required for Normal Mitogenic or Transforming Signal Generation (1991) (0)
Differential Effects ofcAMPontheMAP Kinase Cascade: Evidence foracAMP-insensitive Stepthat CanBypassRaf-I (1995) (0)
to Degranulation and Host Defense Responses Pyk2 Is Required for Neutrophil (0)
Brain Tumors Expression of Epidermal Growth Factor Receptors in Human Updated Version (2006) (0)
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With 3,5-dimethyl-1-(3-nitro-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester (2005) (0)
JAK2 JH2 in complex with JAK168 (2020) (0)
Annotated References Oncologic, Endocrine and Metabolic (1994) (0)
A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers (2018) (0)
Exposing the Obscured Influence of State-Controlled Media: A Causal Estimation of Influence Between Media Outlets Via Quotation Propagation (2022) (0)
Crystal Structure of Beta-Klotho in Complex with FGF21CT (2018) (0)
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 (1997) (0)
Receptors of growth factors of fibroblast (1991) (0)
receptor monoclonal antibodies specific growth factor of human epidermis and therapeutic compositions containing them. (1989) (0)
JAK2 JH2 in complex with JNJ-7706621 (2017) (0)
Covalent Modification of the JH2 Domain of Janus Kinase 2. (2022) (0)
Therapeutic compositions containing monoclonal antibodies against the human receptor for epidermal growth factor (1989) (0)
Tyrosine kinases to Ras (1993) (0)
Crystal structure of the exctracellular domain of the receptor tyrosine kinase, Kit (2007) (0)
The Role of FAK, Pyk2 and Fyn in Pretarget Sorting and Topographic Mapping of the Visual System (2010) (0)
JAK2 JH2 in complex with diaminopyrimidine JAK040 (2018) (0)
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU4984 INHIBITOR (1998) (0)
Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 3,5-dimethyl-1-(3-nitro-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester (2005) (0)
COMP 374-Potent inhibitors of mutant-B-Raf and Fms kinases designed using a scaffold-based drug discovery approach (2008) (0)
Crystal structure of the PI3-kinase p85 N-terminal SH2 domain (2006) (0)
Structure of Beta-Klotho in Complex with FGF19 C-terminal peptide (2019) (0)
Induces Regression of Established Tumors SU 6668 Is a Potent Antiangiogenic and Antitumor Agent That Updated (2000) (0)
Crystal Structure of the Focal Adhesion Targeting (FAT) Domain of Pyk2 (2009) (0)
JAK2 JH2 in complex with NVP-BSK805 (2017) (0)
Structural features of growth factor receptors with oncogenic potential. (1986) (0)
JAK2 JH2 in complex with JAK020 (2021) (0)
Gi2-mediated Activation oftheMAP KinaseCascade AnnM.Pace,* MichelFaure,t andHenryR.Bournet (1995) (0)
Structural basis of KIT activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand-dependent or oncogenic receptor tyrosine kinase activation (2015) (0)
CRYSTAL STRUCTURE OF FGF1 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 1 (FGFR1) (2000) (0)
Cryo-EM analyses of wild-type and oncogenic KIT mutants reveal structural oncogenic plasticity and a novel “Achilles heel” for therapeutic intervention (2022) (0)
JAK2 JH2 in complex with NU6102 (2018) (0)
X-Ray Diffraction data from human KIT D4D5 harboring oncogenic mutation T417I, Δ418,419, source of 4PGZ structure (2015) (0)
FGFR4: FGF receptor-4 (vertebrates) (1995) (0)
JAK2 JH1 in complex with JNJ-7706621 (Crystal Form 2) (2018) (0)
JAK2 JH2 in complex with JAK190 (2020) (0)
Chicken Epidermal GrowthFactor (EGF)Receptor: cDNACloning, Expression inMouseCells, andDifferential Binding ofEGFand Transforming GrowthFactor Alpha (1988) (0)
Crystal Structure of activated receptor tyrosine kinase in complex with substrates (2009) (0)
binding and Ras activation. beta-receptor kinase insert is involved in GRB2 Tyr-716 in the platelet-derived growth factor (2013) (0)
Crystal structure of VEGFR2 extracellular domain D7 (2010) (0)
JAK2 JH2 in complex with JAK064 (2021) (0)
Molecular Features Involved in Cell Surface Receptor Function and Their Role in Oncogenesis (1987) (0)
Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibodies Fab79D (2013) (0)
CELLULAR SIGNALING BY TYROSINE PHOSPHORYLATION (2000) (0)
JAK2 JH2 in complex with PRT062607 (2017) (0)
Molecular Recognition mediated by SH2 and SH3 : Case Study of Ash/Grb2 (1996) (0)
JAK2 JH2 in complex with JAK146 (2020) (0)
Structure of phosphotransferase (2008) (0)
Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with PDGFR phosphotyrosyl peptide (2006) (0)
MA16.02 Mutational Landscape of TKI Naïve and Resistant EGFR Mutant Lung Adenocarcinomas (2017) (0)
Engineering diaminotriazole ligands into ATP-mimetics for selective targeting of the Janus kinase 2 (JAK2) pseudokinase domain (JH2) (2021) (0)
Structure of the mutant Fibroblast Growth Factor receptor 1 (2010) (0)
Tony Pawson (1952–2013) (2013) (0)
Analysis and Transfection of Human Acidic Fibroblast Growth Factor (aFGF) cDNA Clones and Structural Analysis of the Human aFGF Gene reveals Features Shared within a Family of Homologous Proteins (1990) (0)
The Membrane Receptor for Epidermal Growth Factor (1985) (0)
Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability. (2023) (0)
Tyr-716 inthePlatelet-Derived GrowthFactor3-Receptor Kinase Insert IsInvolved inGRB2Binding andRasActivation (1994) (0)
CRYSTAL STRUCTURE OF THE ARF-GAP DOMAIN AND ANKYRIN REPEATS OF PAPBETA. (1999) (0)
X-Ray Diffraction data from human KIT D4D5 in complex with Fab79D, source of 4K9E structure (2015) (0)
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Filaminast (2004) (0)
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R,S)-Rolipram (2004) (0)
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Roflumilast (2004) (0)
Identification oftheCysteine Residues Involved inthe Class IDisulfide BondsoftheHumanInsulin Receptor: Properties ofInsulin Receptor Monomers (1996) (0)
JAK2 JH2 in complex with BI-D1870 (2017) (0)
Signal transduction by EGF-receptor and ist mutants (1989) (0)
Monoclonal antibodies against epidermal growthfactor receptor induce prolactin synthesis incultured ratpituitary cells (GH3) (membrane receptor/gene expression/hormone (1983) (0)
Abstract 89: Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma (2016) (0)
Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up. (2017) (0)
PH domains: diverse sequences with a common membrane association function (1996) (0)
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU5402 INHIBITOR (1998) (0)
JAK2 JH2 in complex with JAK170 (2020) (0)
Editorial Board (2010) (0)
Condorcet Optimal Clustering with Delaunay Triangulation: Climate Zones and World Happiness Insights (2019) (0)
Erratum: Mutations in different components of FGF signaling in LADD syndrome (2006) (0)
Unveiling molecular insights into the mechanism of activation of oncogenic phosphoinositide 3-kinase mutants. (2022) (0)
JAK2 JH2 in complex with AT9283 (2017) (0)
Abstract A09: Impaired HLA Class I antigen processing and presentation as a mechanism of acquired Rrsistance to immune checkpoint inhibitors in lung cancer (2018) (0)
JAK2 JH2 in complex with GLPG0634 (2017) (0)
407 Structural basis for inhibition of ligand-dependent and -independent ErbB3 activation by KTN3379 (2014) (0)
[Structural biology of receptor tyrosine kinase kit]. (2008) (0)
Catalytic Domain Of Human Phosphodiesterase 4D In Complex With 1-(4-methoxy-phenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester (2005) (0)
Crystal Structure of sErbB3-Fab3379 Complex (2015) (0)
Structural studies of receptor tyrosine kinases (1996) (0)
Crystal Structure of the Focal Adhesion Targeting (FAT) Domain of Pyk2 in Complex with Paxillin LD4 Motif-Derived Peptides (2009) (0)
FGFR2: FGF receptor-2 (vertebrates) (Bacterial expressed) kinase, bek, Keratinocyte growth factor receptor) (1995) (0)
Receptor Tyrosine Kinases: Insights from Structure (2010) (0)
Protein-binding proteins designed from target structural information (2022) (0)
Catalytic Domain Of Human Phosphodiesterase 5A in Complex with GMP (2004) (0)
8 – Structural basis of growth factor receptor mediated cellular signals (abstract) (1987) (0)
ActivationofInsulin-EpidermalGrowth Factor(EGF) Receptor Chimerae RegulatesEGF ReceptorBinding Affinity (1992) (0)
Mutational Analysis of the EGF Receptor Proto-Oncogene (1989) (0)
JAK2 JH2 in complex with 63552444 (2018) (0)
Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Zardaverine (2004) (0)
Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis (2022) (0)
FUNCTIONAL INTERACTIONS BETWEEN RECEPTOR TYROSINE PHOSPHATASE β AND THE AXONAL CELL RECOGNITION RECEPTOR CONTACTIN (1996) (0)
Catalytic Domain Of Human Phosphodiesterase 5A in Complex with Sildenafil (2004) (0)
STRUCTURE OF STEM CELL FACTOR (2000) (0)
living cells. autophosphorylation of the EGF receptors in (EGF)-induced intermolecular Evidence for epidermal growth factor (2013) (0)
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With AMP (2004) (0)
JAK2 JH2 in complex with a diaminopyrimidine (2017) (0)
The tyrosine kinase PYK2 integrates TCR and LFA-1 signaling in CD8 T cells to promote effector versus memory fate (83.21) (2009) (0)
Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention. (2023) (0)
TGFI3-induced GrowthInhibition inPrimary Fibroblasts Requires theRetinoblastoma Protein (1996) (0)
Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with c-Kit phosphotyrosyl peptide (2006) (0)
Crystal Structure of Beta-Klotho (2018) (0)
10 – The EGF Receptor Protooncogene: Structure, Evolution of Properties of Receptor Mutants (1991) (0)
Table of Contents (1990) (0)
Improvements to growth factors. (1985) (0)
NOUVELLE PHOSPHOTYROSINE PHOSPHATASE - σ à FONCTION RECEPTEUR (1994) (0)
Separation ofv-Src-induced Mitogenesis and Morphological Transformation byInhibition ofAP-1 (1994) (0)
JAK2 JH1 in complex with JNJ-7706621 (2017) (0)
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Cilomilast (2004) (0)
JAK2 JH2 in complex with JAK179 (2020) (0)
Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies (2023) (0)
Abstract 1672: Structural basis for inhibition of ligand-dependent and -independent ErbB3 activation by KTN3379 (2015) (0)
Temporal resolution of protein signaling (473.1) (2014) (0)
Crystal structure of minimal kinase domain of fibroblast growth factor receptor 1 in complex with 5-(2-thienyl)nicotinic acid (2010) (0)
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Sildenafil (2004) (0)
White paper: The International Receptor Tyrosine Kinase Networks Consortium (2005) (0)
Catalytic Domain Of Human Phosphodiesterase 1B (2004) (0)
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Piclamilast (2004) (0)
and RecyclingofEGF ReceptorMutants (1992) (0)
The structure , function , and pharmacologic inhibition of FGF 23 (2012) (0)
Catalytic Domain Of Human Phosphodiesterase 5A (2004) (0)
Epidermal growth factor (EGF) stimulates association and kinase activity of Raf-1 with the EGF receptor (1991) (0)
Spontaneously Formed EGFR Dimers Are Primed For Activation (2009) (0)
Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Vardenafil (2004) (0)
Development Factor Responses during Early Mouse Component of Multiple Fibroblast Growth Is an Essential α The Docking Protein FRS 2 (2005) (0)
Crystal structure of the extracellular domain of Kit in complex with stem cell factor (SCF) (2007) (0)
CRYSTAL STRUCTURE OF A DIMERIC FGF2-FGFR1 COMPLEX (2000) (0)

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