Joseph Takahashi
#30,863
Most Influential Person Now
American medical investigator
Why Is Joseph Takahashi Influential?
(Suggest an Edit or Addition)According to Wikipedia, Joseph S. Takahashi is a Japanese American neurobiologist and geneticist. Takahashi is a professor at University of Texas Southwestern Medical Center as well as an investigator at the Howard Hughes Medical Institute. Takahashi's research group discovered the genetic basis for the mammalian circadian clock in 1994 and identified the Clock gene in 1997. Takahashi was elected to the National Academy of Sciences in 2003.
Joseph Takahashi's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice (2005) (2234)
- Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock (2002) (2233)
- PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. (2004) (2120)
- Role of the CLOCK protein in the mammalian circadian mechanism. (1998) (1881)
- Central and peripheral circadian clocks in mammals. (2012) (1611)
- Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. (1994) (1604)
- Circadian Integration of Metabolism and Energetics (2010) (1515)
- The genetics of mammalian circadian order and disorder: implications for physiology and disease (2008) (1404)
- Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals (2000) (1402)
- Transcriptional architecture of the mammalian circadian clock (2016) (1356)
- Positional Cloning of the Mouse Circadian Clock Gene (1997) (1349)
- Disruption of the Clock Components CLOCK and BMAL1 Leads to Hypoinsulinemia and Diabetes (2010) (1264)
- Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals (2012) (1147)
- Molecular components of the Mammalian circadian clock. (2013) (1068)
- Suprachiasmatic nucleus: cell autonomy and network properties. (2010) (1029)
- Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis (2009) (992)
- Molecular architecture of the mammalian circadian clock. (2014) (988)
- Mammalian circadian biology: elucidating genome-wide levels of temporal organization. (2004) (948)
- Molecular components of the mammalian circadian clock. (2006) (925)
- The Meter of Metabolism (2008) (855)
- Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau. (2000) (841)
- Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim. (1998) (838)
- Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock. (1993) (833)
- Mania-like behavior induced by disruption of CLOCK (2007) (744)
- Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators (2010) (725)
- Bioluminescence Imaging of Individual Fibroblasts Reveals Persistent, Independently Phased Circadian Rhythms of Clock Gene Expression (2004) (685)
- Intercellular Coupling Confers Robustness against Mutations in the SCN Circadian Clock Network (2007) (673)
- Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2. (1999) (667)
- Functional Identification of the Mouse Circadian Clock Gene by Transgenic BAC Rescue (1997) (660)
- System-Driven and Oscillator-Dependent Circadian Transcription in Mice with a Conditionally Active Liver Clock (2007) (648)
- Regulation of Circadian Behavior and Metabolism by Synthetic REV-ERB Agonists (2012) (593)
- A CLOCK polymorphism associated with human diurnal preference. (1998) (586)
- Spectral sensitivity of a novel photoreceptive system mediating entrainment of mammalian circadian rhythms (1984) (540)
- Circadian Mutant Overtime Reveals F-box Protein FBXL3 Regulation of Cryptochrome and Period Gene Expression (2007) (523)
- Molecular genetics of circadian rhythms in mammals. (2000) (522)
- Photic and circadian regulation of c-fos gene expression in the hamster suprachiasmatic nucleus (1990) (521)
- Genetics of circadian rhythms in Mammalian model organisms. (2011) (489)
- Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation (2007) (486)
- Mutant Mice and Neuroscience: Recommendations Concerning Genetic Background (1997) (477)
- Regulation of dopaminergic transmission and cocaine reward by the Clock gene. (2005) (459)
- cAMP-Dependent Signaling as a Core Component of the Mammalian Circadian Pacemaker (2008) (406)
- Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses. (1998) (402)
- Clock controls circadian period in isolated suprachiasmatic nucleus neurons (1998) (383)
- FGF21 regulates metabolism and circadian behavior by acting on the nervous system (2013) (381)
- The Circadian Clock Mutation Alters Sleep Homeostasis in the Mouse (2000) (366)
- Mammalian Circadian Autoregulatory Loop A Timeless Ortholog and mPer1 Interact and Negatively Regulate CLOCK-BMAL1-Induced Transcription (1998) (357)
- Setting Clock Speed in Mammals: The CK1ɛ tau Mutation in Mice Accelerates Circadian Pacemakers by Selectively Destabilizing PERIOD Proteins (2008) (348)
- TH17 Cell Differentiation Is Regulated by the Circadian Clock (2013) (332)
- Stopping time: the genetics of fly and mouse circadian clocks. (2001) (325)
- Circadian Clock Mutation Disrupts Estrous Cyclicity and Maintenance of Pregnancy (2004) (324)
- Identification of the circadian transcriptome in adult mouse skeletal muscle. (2007) (322)
- The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome. (2016) (315)
- A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo. (2005) (314)
- Sensitivity and integration in a visual pathway for circadian entrainment in the hamster (Mesocricetus auratus). (1991) (313)
- Regulation of circadian rhythmicity. (1982) (309)
- CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function (2010) (305)
- Dissecting the Functions of the Mammalian Clock Protein BMAL1 by Tissue-Specific Rescue in Mice (2006) (286)
- Genetics of the mammalian circadian system: Photic entrainment, circadian pacemaker mechanisms, and posttranslational regulation. (2000) (286)
- Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm (2013) (286)
- Effects of aging on the circadian rhythm of wheel-running activity in C57BL/6 mice. (1997) (268)
- Overview of Circadian Rhythms (2001) (263)
- Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex. (2005) (258)
- The avian pineal, a vertebrate model system of the circadian oscillator: cellular regulation of circadian rhythms by light, second messengers, and macromolecular synthesis. (1989) (258)
- Circadian rhythms of melatonin release from individual superfused chicken pineal glands in vitro. (1980) (253)
- Genome-wide epistatic interaction analysis reveals complex genetic determinants of circadian behavior in mice. (2001) (249)
- Forward and reverse genetic approaches to behavior in the mouse. (1994) (238)
- Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex (2012) (237)
- BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output (2006) (235)
- The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude. (2006) (226)
- Circadian Rhythm Generation and Entrainment in Astrocytes (2005) (225)
- Use of 2-[125I]iodomelatonin to characterize melatonin binding sites in chicken retina. (1987) (224)
- Targeted Deletion of the Vgf Gene Indicates that the Encoded Secretory Peptide Precursor Plays a Novel Role in the Regulation of Energy Balance (1999) (220)
- CKIε/δ-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock (2009) (214)
- Time- and exercise-dependent gene regulation in human skeletal muscle (2003) (214)
- Regulation of jun-B messenger RNA and AP-1 activity by light and a circadian clock. (1992) (210)
- Genomics of circadian rhythms in health and disease (2019) (210)
- Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism. (2009) (207)
- Cell autonomy and synchrony of suprachiasmatic nucleus circadian oscillators (2011) (204)
- Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis (2012) (203)
- Forward-genetics analysis of sleep in randomly mutagenized mice (2016) (200)
- Emergence of Noise-Induced Oscillations in the Central Circadian Pacemaker (2010) (195)
- Real-time luminescence reporting of circadian gene expression in mammals. (2005) (190)
- Medicine in the Fourth Dimension. (2019) (188)
- Circadian regulation of lodopsin gene expression in embryonic photoreceptors in retinal cell culture (1993) (175)
- C57BL/6N Mutation in Cytoplasmic FMRP interacting protein 2 Regulates Cocaine Response (2013) (170)
- Molecular components of the circadian clock in mammals (2015) (164)
- Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening (2011) (159)
- The mouse Clock mutation behaves as an antimorph and maps within the W19H deletion, distal of Kit. (1997) (158)
- Aging Alters Circadian and Light-Induced Expression of Clock Genes in Golden Hamsters (2003) (158)
- Circadian Clock Genes and the Transcriptional Architecture of the Clock Mechanism. (2018) (156)
- Photic and circadian expression of luciferase in mPeriod1-luc transgenic mice in vivo (2001) (151)
- The orphan receptor Rev-erbα gene is a target of the circadian clock pacemaker (2004) (151)
- Circadian Clock Genes Contribute to the Regulation of Hair Follicle Cycling (2009) (151)
- Light, immediate-early genes, and circadian rhythms (1996) (150)
- Familial advanced sleep phase syndrome. (2001) (149)
- Effects of aging on light-induced phase-shifting of circadian behavioral rhythms, Fos expression and creb phosphorylation in the hamster suprachiasmatic nucleus (1996) (148)
- Guidelines for Genome-Scale Analysis of Biological Rhythms (2017) (146)
- Chimera Analysis of the Clock Mutation in Mice Shows that Complex Cellular Integration Determines Circadian Behavior (2001) (144)
- The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy. (2018) (143)
- Characteristics and autoradiographic localization of 2-[125I]iodomelatonin binding sites in Djungarian hamster brain. (1989) (143)
- Mice under Caloric Restriction Self-Impose a Temporal Restriction of Food Intake as Revealed by an Automated Feeder System. (2017) (140)
- Role of the suprachiasmatic nuclei in the circadian system of the house sparrow, Passer domesticus (1982) (138)
- The physiology of circadian pacemakers. (1978) (137)
- MOLECULAR NEUROBIOLOGY AND GENETICS OF CIRCADIAN RHYTHMS IN MAMMALS (1995) (137)
- Functional Annotation of Mouse Genome Sequences (2001) (136)
- 2-[125I]iodomelatonin binding sites in hamster brain membranes: pharmacological characteristics and regional distribution. (1988) (135)
- Neuromedin S-Producing Neurons Act as Essential Pacemakers in the Suprachiasmatic Nucleus to Couple Clock Neurons and Dictate Circadian Rhythms (2015) (134)
- Future of genetics of mood disorders research (2002) (131)
- Finding New Clock Components: Past and Future (2004) (130)
- Differential effects of light and feeding on circadian organization of peripheral clocks in a forebrain Bmal1 mutant (2014) (128)
- Handbook of Behavioral Neurobiology (2001) (119)
- Sex- and lineage-specific inheritance of depression-like behavior in the rat (2004) (116)
- The Basic Helix-Loop-Helix-PAS Protein MOP9 Is a Brain-Specific Heterodimeric Partner of Circadian and Hypoxia Factors (2000) (115)
- Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei. (1999) (113)
- Central Circadian Control of Female Reproductive Function (2014) (109)
- Gene Set Enrichment in eQTL Data Identifies Novel Annotations and Pathway Regulators (2008) (109)
- In vivo single-cell detection of metabolic oscillations in stem cells. (2015) (108)
- Vasopressin Regulation of the Proestrous Luteinizing Hormone Surge in Wild-Type and Clock Mutant Mice1 (2006) (107)
- Magnetic sensitivity of cryptochrome 4 from a migratory songbird (2021) (106)
- Small molecule modifiers of circadian clocks (2013) (100)
- Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse. (2006) (99)
- Interaction of estradiol and progesterone: effects on circadian locomotor rhythm of female golden hamsters. (1980) (98)
- Brain-Specific Rescue of Clock Reveals System-Driven Transcriptional Rhythms in Peripheral Tissue (2012) (98)
- Development and Therapeutic Potential of Small-Molecule Modulators of Circadian Systems. (2018) (95)
- Circadian-clock regulation of gene expression. (1993) (94)
- Light-induced decrease of serotonin N-acetyltransferase activity and melatonin in the chicken pineal gland and retina (1983) (93)
- Searching for Genes Underlying Behavior: Lessons from Circadian Rhythms (2008) (93)
- Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge (2019) (93)
- Comparison of visual sensitivity for suppression of pineal melatonin and circadian phase-shifting in the golden hamster (1991) (93)
- Genetics and neurobiology of circadian clocks in mammals. (2007) (90)
- The orphan receptor Rev-erbalpha gene is a target of the circadian clock pacemaker. (2004) (90)
- Bmal1 function in skeletal muscle regulates sleep (2017) (88)
- The Circadian Clock in Skin (2015) (87)
- Automated measurement of mouse freezing behavior and its use for quantitative trait locus analysis of contextual fear conditioning in (BALB/cJ x C57BL/6J)F2 mice. (1998) (87)
- Genomewide Association Analysis in Diverse Inbred Mice: Power and Population Structure (2007) (86)
- Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex (2014) (86)
- Adenylate cyclase activation shifts the phase of a circadian pacemaker. (1983) (84)
- Circadian rhythms: molecular basis of the clock. (1998) (83)
- Implementing Large-Scale ENU Mutagenesis Screens in North America (2004) (82)
- Phosphorylation of LSD1 by PKCα is crucial for circadian rhythmicity and phase resetting. (2014) (80)
- Tissue-specific BMAL1 cistromes reveal that rhythmic transcription is associated with rhythmic enhancer–enhancer interactions (2019) (79)
- Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1. (2018) (78)
- Integration and saturation within the circadian photic entrainment pathway of hamsters. (1999) (76)
- FGF21 regulates circadian behavior and metabolism by acting on the nervous system (2013) (76)
- HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors (2017) (76)
- Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1 (2017) (76)
- Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function. (2004) (75)
- Circadian Clock Genes as Modulators of Sensitivity to Genotoxic Stress (2005) (73)
- Circadian clock genes are ticking. (1992) (73)
- Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder (2015) (73)
- Two families of phase-response curves characterize the resetting of the hamster circadian clock. (1992) (71)
- Hepatocyte circadian clock controls acetaminophen bioactivation through NADPH-cytochrome P450 oxidoreductase (2014) (70)
- Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron. (2019) (70)
- Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice (2022) (69)
- Lithium Ameliorates Nucleus Accumbens Phase-Signaling Dysfunction in a Genetic Mouse Model of Mania (2010) (69)
- Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice (2013) (69)
- Effect of circadian phase on context and cued fear conditioning in C57BL/6J mice (2001) (69)
- Importance of circadian timing for aging and longevity (2021) (68)
- The gene for soluble N-ethylmaleimide sensitive factor attachment protein alpha is mutated in hydrocephaly with hop gait (hyh) mice. (2004) (67)
- Generation, identification and functional characterization of the nob4 mutation of Grm6 in the mouse (2007) (67)
- Neuropeptide Y stimulates luteinizing hormone-releasing hormone release from superfused hypothalamic GT1-7 cells. (1994) (66)
- Light-dependent regulation of dopamine receptors in mammalian retina (1985) (65)
- Physiology of avian circadian pacemakers. (1979) (65)
- An evolutionary hotspot defines functional differences between CRYPTOCHROMES (2018) (65)
- Anisomycin, an inhibitor of protein synthesis, perturbs the phase of a mammalian circadian pacemaker (1987) (65)
- Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage. (2017) (64)
- The circadian clock in skin: implications for adult stem cells, tissue regeneration, cancer, aging, and immunity (2015) (64)
- Trypanosoma brucei metabolism is under circadian control (2017) (64)
- Period2 3′-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation (2017) (63)
- Chemical and structural analysis of a photoactive vertebrate cryptochrome from pigeon (2019) (63)
- Sleeping sickness is a circadian disorder (2018) (63)
- Locomotor response to an open field during C57BL/6J active and inactive phases differences dependent on conditions of illumination (2000) (62)
- Phosphorylation of the Cryptochrome 1 C-terminal Tail Regulates Circadian Period Length* (2013) (62)
- Circadian rhythms: From gene expression to behavior (1991) (61)
- Methods to record circadian rhythm wheel running activity in mice. (2005) (61)
- Inducible and Reversible Clock Gene Expression in Brain Using the tTA System for the Study of Circadian Behavior (2007) (60)
- Interpretation of the mouse electroretinogram (2007) (60)
- Immediate-Early Gene Expression in a Mammalian Circadian Pacemaker, the Suprachiasmatic Nucleus (1992) (59)
- Transcriptional program of Kpna2/Importin-α2 regulates cellular differentiation-coupled circadian clock development in mammalian cells (2014) (59)
- Loss of circadian photoentrainment and abnormal retinal electrophysiology in Math5 mutant mice. (2005) (59)
- Twenty-four hour oscillation of cAMP in chick pineal cells: Role of cAMP in the acute and circadian regulation of melatonin production (1989) (58)
- Molecular approaches to understanding circadian oscillations. (1993) (57)
- A cholinergic antagonist, mecamylamine, blocks the phase-shifting effects of light on the circadian rhythm of locomotor activity in the golden hamster (1987) (56)
- Molecular Architecture of the Circadian Clock in Mammals (2016) (56)
- Cycling Transcriptional Networks Optimize Energy Utilization on a Genome Scale. (2015) (55)
- Genetic analysis of the stress-responsive adrenocortical axis. (2006) (53)
- Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway (2010) (52)
- Molecular neurobiology and genetics of circadian rhythms in mammals. (1995) (52)
- The malaria parasite has an intrinsic clock (2020) (49)
- Effects of aging on lens transmittance and retinal input to the suprachiasmatic nucleus in golden hamsters (1998) (49)
- Circadian rhythms: The cancer connection (2002) (49)
- Effects of age on circadian rhythms are similar in wild-type and heterozygous Clock mutant mice (2004) (49)
- The microbiota coordinates diurnal rhythms in innate immunity with the circadian clock (2021) (49)
- Vasoactive Intestinal Polypeptide (VIP)-Expressing Neurons in the Suprachiasmatic Nucleus Provide Sparse GABAergic Outputs to Local Neurons with Circadian Regulation Occurring Distal to the Opening of Postsynaptic GABAA Ionotropic Receptors (2015) (48)
- Depressive-like behavior and stress reactivity are independent traits in a Wistar Kyoto × Fisher 344 cross (2003) (48)
- Circadian rhythms: Redox redux (2011) (47)
- Dynamics of noradrenergic circadian input to the chicken pineal gland (1986) (47)
- A tunable artificial circadian clock in clock-defective mice (2015) (44)
- Large-scale mutagenesis and phenotypic screens for the nervous system and behavior in mice (2006) (44)
- Circadian transcriptional output in the SCN and liver of the mouse. (2003) (44)
- A cholinergic antagonist, mecamylamine, blocks light-induced Fos immunoreactivity in specific regions of the hamster suprachiasmatic nucleus (1993) (43)
- Effects of aging on the circadian rhythm of wheel-running activity in C57BL/6 mice. (1997) (43)
- Impaired Limbic Gamma Oscillatory Synchrony during Anxiety-Related Behavior in a Genetic Mouse Model of Bipolar Mania (2011) (42)
- The Xenopus clock gene is constitutively expressed in retinal photoreceptors. (2000) (42)
- Test- and behavior-specific genetic factors affect WKY hypoactivity in tests of emotionality (2006) (39)
- Dual-Color Single-Cell Imaging of the Suprachiasmatic Nucleus Reveals a Circadian Role in Network Synchrony (2020) (39)
- Alterations in the circadian system in advanced age. (1995) (39)
- Circadian Rhythms: ICER is nicer at night (sir!) (1994) (39)
- Regulation of the vgf gene in the golden hamster suprachiasmatic nucleus by light and by the circadian clock (1997) (38)
- Visual sensitivities of nur77 (NGFI-B) and zif268 (NGFI-A) induction in the suprachiasmatic nucleus are dissociated from c-fos induction and behavioral phase-shifting responses. (1997) (38)
- Light entrainment and activation of signal transduction pathways in the SCN. (1996) (37)
- Inhibitor of protein synthesis phase shifts a circadian pacemaker in mammalian SCN. (1988) (36)
- Fos protein expression in the circadian clock is not associated with phase shifts induced by a nonphotic stimulus, triazolam (1993) (34)
- Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies (2016) (34)
- Vasoactive intestinal polypeptide and alpha 2-adrenoceptor agonists regulate adenosine 3',5'-monophosphate accumulation and melatonin release in chick pineal cell cultures. (1989) (32)
- Divergent and nonuniform gene expression patterns in mouse brain (2010) (32)
- X-linked and lineage-dependent inheritance of coping responses to stress (2003) (31)
- Circadian Behavior and Plasticity of Light-Induced c-fos Expression in SCN of tau Mutant Hamsters (1998) (31)
- Immunocytochemical localization of serotonergic fibers innervating the ocular circadian system of Aplysia (1989) (31)
- Molecular cloning of chick pineal tryptophan hydroxylase and circadian oscillation of its mRNA levels. (1996) (30)
- Pharmacological and Genetic Approaches for the Study of Circadian Rhythms in Mammals (1995) (30)
- Circadian control of interferon-sensitive gene expression in murine skin (2020) (29)
- Novel transcriptional networks regulated by CLOCK in human neurons (2017) (29)
- Cyclic AMP‐Dependent Melatonin Production in Y79 Human Retinoblastoma Cells (1989) (27)
- The circadian clock: from molecules to behaviour. (1995) (27)
- Light-dependent Activation of Rod Transducin by Pineal Opsin* (1998) (27)
- Nonphotic phase-shifting in Clock mutant mice (2000) (27)
- Lability of Circadian Pacemaker Amplitude in Chick Pineal Cells: A Temperature-Dependent Process (1997) (26)
- A pertussis toxin-sensitive G-protein mediates the alpha 2-adrenergic receptor inhibition of melatonin release in photoreceptive chick pineal cell cultures. (1988) (25)
- Noise-driven cellular heterogeneity in circadian periodicity (2020) (25)
- Characterization of the Chicken Rhodopsin Promoter: Identification of Retina-Specific and glass-like Protein Binding Domains (1994) (25)
- Characterization of 2-[125I]iodomelatonin binding sites in hamster brain. (1986) (25)
- Critical period for cycloheximide blockade of light-induced phase advances of the circadian locomotor activity rhythm in golden hamsters (1996) (25)
- Forward genetic screens to identify circadian rhythm mutants in mice. (2005) (25)
- ChIP-seq and RNA-seq methods to study circadian control of transcription in mammals. (2015) (25)
- Second-generation high-throughput forward genetic screen in mice to isolate subtle behavioral mutants (2011) (25)
- Results from screening over 9000 mutation-bearing mice for defects in the electroretinogram and appearance of the fundus (2004) (24)
- Enriching the Circadian Proteome. (2017) (24)
- A Circadian Sleep Disorder Reveals a Complex Clock (2007) (23)
- Circadian rhythms in parasites (2017) (21)
- Lineage is an Epigenetic Modifier of QTL Influencing Behavioral Coping with Stress (2005) (21)
- NPAS4 regulates the transcriptional response of the suprachiasmatic nucleus to light and circadian behavior (2021) (20)
- Regulation of Tryptophan Hydroxylase by Cyclic AMP, Calcium, Norepinephrine, and Light in Cultured Chick Pineal Cells (1996) (20)
- Multiple redundant circadian oscillators within the isolated avian pineal gland (1984) (20)
- Chemical perturbations reveal that RUVBL2 regulates the circadian phase in mammals (2020) (20)
- Phase shifting the circadian clock with cycloheximide: response of hamster with an intact or a split rhythm of locomotor activity (1989) (20)
- Generation, characterization, and molecular cloning of the Noerg-1 mutation of rhodopsin in the mouse (2005) (20)
- Cell-autonomous regulation of astrocyte activation by the circadian clock protein BMAL1 (2018) (20)
- HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections (2017) (19)
- N-acetyltransferase and protein synthesis modulate melatonin production by Y79 human retinoblastoma cells (1991) (18)
- Ghrelin-immunopositive hypothalamic neurons tie the circadian clock and visual system to the lateral hypothalamic arousal center. (2012) (18)
- The mouse Clock locus: sequence and comparative analysis of 204 kb from mouse chromosome 5. (2000) (18)
- Loss of ZBTB20 impairs circadian output and leads to unimodal behavioral rhythms (2016) (17)
- Introduction to Circadian Rhythms (2001) (17)
- Calcium modulates circadian variation in cAMP-stimulated melatonin in chick pineal cells (1996) (17)
- Entrainment of the circadian system of the house sparrow: A population of oscillators in pinealectomized birds (1982) (17)
- An actigraphy study investigating sleep in bipolar I patients, unaffected siblings and controls. (2017) (17)
- Day/Night Differences in the Stimulation of Adenylate Cyclase Activity by Calcium/Calmodulin in Chick Pineal Cell Cultures: Evidence for Circadian Regulation of Cyclic AMP (1998) (17)
- Correction: Emergence of Noise-Induced Oscillations in the Central Circadian Pacemaker (2010) (17)
- Generation of N-Ethyl-N-nitrosourea (ENU) Diabetes Models in Mice Demonstrates Genotype-specific Action of Glucokinase Activators* (2011) (17)
- Forward genetic approaches to circadian clocks in mice. (1996) (16)
- Epigenetic inheritance of circadian period in clonal cells (2020) (15)
- Maternal behavior modulates x-linked inheritance of behavioral coping in the defensive burying test (2004) (15)
- Identification of genetic loci involved in diabetes using a rat model of depression (2009) (14)
- Biological Rhythms: From Gene Expression to Behavior (1993) (14)
- Circadian Rhythmicity: Regulation in the Time Domain (1984) (14)
- Quantitative trait loci associated with elevated thyroid-stimulating hormone in the Wistar-Kyoto rat. (2005) (14)
- An essential role for MEF2C in the cortical response to loss of sleep in mice (2020) (14)
- Narcolepsy Genes Wake Up the Sleep Field (1999) (13)
- Mean-Variance QTL Mapping Identifies Novel QTL for Circadian Activity and Exploratory Behavior in Mice (2018) (12)
- Quantitative Two-Dimensional Gel Electrophoretic Analysis of Clock-Controlled Proteins in Cultured Chick Pineal Cells: Circadian Regulation of Tryptophan Hydroxylase (1996) (11)
- Xenobiotic metabolism in the fourth dimension: PARtners in time. (2006) (9)
- Natural antisense transcript of Period2, Per2AS, regulates the amplitude of the mouse circadian clock (2020) (9)
- PARP around the Clock (2010) (9)
- Molecular biological clocks (1995) (9)
- A novel mouse model overexpressing Nocturnin results in decreased fat mass in male mice (2019) (9)
- Time to target the circadian clock for drug discovery. (2022) (8)
- Ion channels get the message (1996) (8)
- Genetic analysis of the circadian system of mammals: properties and prospects (1995) (8)
- Identification of mutations through dominant screening for obesity using C57BL/6 substrains (2016) (8)
- Neuronal Myocyte-Specific Enhancer Factor 2D (MEF2D) Is Required for Normal Circadian and Sleep Behavior in Mice (2019) (8)
- Sleeping Sickness Disrupts the Sleep-Regulating Adenosine System (2020) (8)
- Epidermal stem cells ride the circadian wave (2013) (8)
- Synchronization between peripheral circadian clock and feeding-fasting cycles in microfluidic device sustains oscillatory pattern of transcriptome (2021) (8)
- Power and Population Structure (2007) (7)
- Sleeping Sickness: A Tale of Two Clocks (2020) (7)
- The biological clock: it's all in the genes. (1996) (7)
- RNA synthesis inhibitors increase melatonin production in Y79 human retinoblastoma cells. (1994) (6)
- Circadian Oscillations of NADH Redox State Using a Heterologous Metabolic Sensor in Mammalian Cells* (2016) (6)
- Neural Mechanisms in Avian Circadian Systems: Hypothalamic Pacemaking Systems (1982) (5)
- Functional identification of neural genes (2001) (5)
- An essential role for MEF2C in the cortical response to loss of sleep (2020) (5)
- Adverse impact of polyphasic sleep patterns in humans: Report of the National Sleep Foundation sleep timing and variability consensus panel. (2021) (5)
- Biological Rhythms and the Pineal Gland (1996) (5)
- Chapter 2.1.7 Genetic dissection of mouse behavior using induced mutagenesis (1999) (5)
- Handbook of Behavioral Neurobiology vol. 12 (2003) (4)
- Circadian rhythms in infectious diseases and symbiosis. (2021) (3)
- Introduction to the Clock System. (2021) (3)
- Coupling-dependent metabolic ultradian rhythms in confluent cells (2022) (3)
- Tissue-specific FAH deficiency alters sleep–wake patterns and results in chronic tyrosinemia in mice (2019) (3)
- Genetic analysis of activity, brain and behavioral associations in extended families with heavy genetic loading for bipolar disorder (2019) (3)
- The mammalian circadian system: From genes to behavior (2007) (3)
- Circadian Rhythms of the Isolated Chicken Pineal in Vitro (1982) (3)
- Tissue-specific BMAL1 cistromes reveal that enhancer-enhancer interactions regulate rhythmic transcription (2018) (3)
- Circadian rhythms: from gene expression to behaviour (1992) (2)
- Molecular Genetics of Circadian Clocks in Mammals (2003) (2)
- Author response: Differential effects of light and feeding on circadian organization of peripheral clocks in a forebrain Bmal1 mutant (2014) (2)
- Phase-Resetting Sensitivity of the Suprachiasmatic Nucleus and Oscillator Amplitude (2011) (2)
- Mouse chimeras and their application to circadian biology. (2005) (2)
- Gene regulation. Circadian clocks à la CREM. (1993) (2)
- Epidermal stem cells ride the circadian wave (2013) (1)
- Genetic control of the circadian pacemaker (2006) (1)
- Erratum: BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output (2006) (1)
- Molecular and Genetic Bases for the Circadian System (2013) (1)
- Circadian rhythms ofmelatonin release fromindividual superfused chicken pineal glands invitro (1980) (1)
- A study on quantitative assessment of the sleep cycle (1996) (1)
- Regulation of melatonin production in human retinoblastoma cells (1989) (1)
- 2. Molecular Architecture of the Circadian Clock in Mammals (2018) (1)
- Gut Microbes and the Liver Circadian Clock Partition Glucose and Lipid Metabolism (2022) (1)
- Genetic Analysis of Daily Activity in Humans and Mice (1999) (1)
- Author response: Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex (2014) (1)
- Photic threshold for stimulation of testicular growth and pituitary FSH release in male Djungarian hamsters (1990) (1)
- A Hyperkinetic Redox Sensor Drives Flies to Sleep (2019) (1)
- Circadian Metabolic Oscillations in the Epidermis Stem Cells by Fluorescence Lifetime Microscopy of NADH in Vivo (2014) (1)
- Integration and saturation within the circadian photic entrainment pathway of hamsters. (1999) (1)
- Author response: Bmal1 function in skeletal muscle regulates sleep (2017) (1)
- Characterization of single nucleotide polymorphisms for a forward genetics approach using genetic crosses in C57BL/6 and BALB/c substrains of mice (2021) (1)
- Michael Menaker (1934-2021) (2021) (1)
- Circadian Rhythm: An Integrated Perspective (2014) (0)
- Abstract 1412: Comprehensive characterization of clock genes in human cancers (2018) (0)
- 138-Plat Circadian Metabolic Oscillations in the Epidermis Stem Cells by Fluores- cence Lifetime Microscopy of NADH in Vivo (2016) (0)
- Molecular Cloning of the Noerg–1 Mutation in Mouse Shows Mutagenesis Can Generate Valid Disease Models (2005) (0)
- Additional data file 6 (2003) (0)
- Bibliography on Seasonal Reproductive Cycles in Mammals: Role of the Pineal Gland: Bibliography of Reproduction (1985) (0)
- Beth Levine M.D. Prize in Autophagy Research (2021) (0)
- Venn diagrams of human genes undergoing diurnal regulation compared to their mouse circadian ortholo (2011) (0)
- Effects of variance of layer depth and bottom friction on dense eddy propagation on slope (2001) (0)
- OF CIRCADIAN PACEMAKERS (1978) (0)
- International Symposium on Biological Rhythm International Joint Symposium on Photonic Bioimaging (2009) (0)
- Mapping and Characterization of Noerg–1 Mutation in Mouse (2004) (0)
- Small molecule modifiers of circadian clocks (2012) (0)
- Pigeon Cryptochrome4 bound to flavin adenine dinucleotide (2019) (0)
- Circadian rhythms. Ion channels get the message. (1996) (0)
- How CRY regulates the clock: structural studies of a dynamic mammalian circadian complex (2020) (0)
- On the relationship between sleep-waking cycle and autonomic function (I) (1995) (0)
- An experimental study on the Sleep Cycle under sleep deprived condixions using heart rate analysis (1997) (0)
- Polysomnographic study of sleep body movement (1996) (0)
- R-R variablity and sleep body movement (1997) (0)
- Experimental Study on an Evaluation of the Sleep Cycle Using a Multidimensional Physiological Measurement (1996) (0)
- A study on relationship between sleep pattern and psychological task performance using polysomnography (1996) (0)
- Disease associations of excessive daytime sleepiness in multiple sclerosis: A prospective study (2023) (0)
- An evolutionary hotspot defines functional differences between CRYPTOCHROMES (2018) (0)
- Sleeping sickness is a circadian disorder (2018) (0)
- An extra-circadian function for human CLOCK in the neocortex (2023) (0)
- Beth Levine M.D. Prize in Autophagy Research. (2021) (0)
- The 50th anniversary of the Konopka and Benzer 1971 paper in PNAS: “Clock Mutants of Drosophila melanogaster” (2021) (0)
- Correction: Inducible and Reversible Clock Gene Expression in Brain Using the tTA System for the Study of Circadian Behavior (2011) (0)
- Genetic Influences on Circadian Rhythms in Mammals (1999) (0)
- NFIL3 suppresses Rorγt transcription and links intestinal Th17 cell differentiation to the circadian clock network (P1223) (2013) (0)
- Circadian Alignment of Feeding Regulates Lifespan Extension by Caloric Restriction (2021) (0)
- Beth Levine M.D. Prize in Autophagy Research. (2021) (0)
- Author response: Loss of ZBTB20 impairs circadian output and leads to unimodal behavioral rhythms (2016) (0)
- Extensive Soma-Soma Plate-Like Contact Sites (Ephapses) Connect Suprachiasmatic Nucleus Neurons (2022) (0)
- Genomics of circadian rhythms in health and disease (2019) (0)
- Asleep at the Wheel: Forward Genetic ENU Mutagenesis Screen for Mouse Models of Chronic Fatigue Identifies a Mutation in Slc2a4 (GLUT4) (2017) (0)
- A missense mutation in Kcnc3 causes hippocampal learning deficits in mice (2022) (0)
- The Small Molecule Nobile tin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome Graphical Abstract Highlights (2016) (0)
- Author response: Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice (2013) (0)
- Light Regulates c-fos Gene Expression in the Hamster SCN: Implications for Circadian and Seasonal Control of Reproduction (1992) (0)
- Phase-resetting Responses in Clock Null Mutant Mice (2009) (0)
- 0059 3-D Reconstruction of Neurons Driving Circadian Rhythms (2019) (0)
- ENU–Induced nob4 Mutant Mouse Available to the Vision Research Community (2006) (0)
- Crystal structure of pigeon Cryptochrome 4 mutant Y319D in complex with flavin adenine dinucleotide (2019) (0)
- Light-dependent activation of transducin by pineal opsin (1996) (0)
- Human genes regulated in the diurnal comparison with orthologs that display circadian regulation in mouse heart and liver ,, and SCN (2011) (0)
- Constant-light Induced Down-regulation of Dopamine Receptors in Retina (1986) (0)
- Dominant Mutation Induced by Chemical Mutagenesis Affecting Mouse ERG and Fundus (2003) (0)
- Title Epidermal stem cells ride the circadian wave Permalink (2013) (0)
- Crystal Structure of Mammalian Period-Cryptochrome Complex (2014) (0)
- Generation ofN-Ethyl-N-nitrosourea (ENU) Diabetes Models in Mice Demonstrates Genotype-specific Action of (2011) (0)
- Title Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage (2017) (0)
- Circadian Regulation of Intestinal Host‐Microbe Interactions (2015) (0)
- Nobuya Koike Circadian Clock in Mammals Transcriptional Architecture and Chromatin Landscape of the Core (2013) (0)
- Chemically Induced Mutations in the Mouse that Affect the Fundus and Electroretinogram (2003) (0)
- Author response: An essential role for MEF2C in the cortical response to loss of sleep in mice (2020) (0)
- MOLECULAR GENETIC APPROACHES TO THE IDENTITY AND FUNCTION OF CIRCADIAN CLOCK GENES (1999) (0)
- Author response: Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies (2016) (0)
- CNOT1 mediates phosphorylation via Protein kinase A on the circadian clock (2019) (0)
- Biosynthesis + Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD (2014) (0)
- of activity ushers in a new era in mammalian genetics (2016) (0)
- Electric Fish: Network Versus Cellular Influences Precision of the Pacemaker Nucleus in a Weakly (2015) (0)
- Mutant Clock Cells, Mutant Clocks (2008) (0)
- A novel mutation in Slc2a4 as a mouse model of fatigue (2019) (0)
- Author response: Epigenetic inheritance of circadian period in clonal cells (2020) (0)
- Strategies for Dissecting the Molecular Mechanisms of Mammalian Circadian Rhythmicity (1998) (0)
- The role of Tmem135 in retinal aging and mitochondrial dynamics (2015) (0)
- 331 Time restricted feeding uncouples the circadian clock and the cell cycle of epidermal stem cells, and alters the sensitivity to UVB-induced DNA damage (2016) (0)
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