Joshua D Rabinowitz
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Molecular Biology
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Chemistry Biology
Joshua D Rabinowitz's Degrees
- PhD Chemistry Princeton University
- Bachelors Chemistry Stanford University
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(Suggest an Edit or Addition)Joshua D Rabinowitz's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Cancer-associated IDH1 mutations produce 2-hydroxyglutarate (2009) (3374)
- The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. (2010) (1776)
- Absolute Metabolite Concentrations and Implied Enzyme Active Site Occupancy in Escherichia coli (2009) (1535)
- Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells (2013) (1192)
- Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. (2011) (1162)
- Autophagy and Metabolism (2010) (1039)
- One-Carbon Metabolism in Health and Disease. (2017) (1003)
- Glucose feeds the TCA cycle via circulating lactate (2017) (899)
- Quantitative flux analysis reveals folate-dependent NADPH production (2014) (836)
- The return of metabolism: biochemistry and physiology of the pentose phosphate pathway (2014) (757)
- Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy (2008) (594)
- Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids (2013) (550)
- Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. (2015) (544)
- Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells (2010) (543)
- Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography-tandem mass spectrometry. (2006) (537)
- Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. (2013) (516)
- Metabolomic analysis and visualization engine for LC-MS data. (2010) (501)
- Mitochondria and Cancer. (2016) (484)
- Metabolomic analysis via reversed-phase ion-pairing liquid chromatography coupled to a stand alone orbitrap mass spectrometer. (2010) (480)
- A roadmap for interpreting (13)C metabolite labeling patterns from cells. (2015) (468)
- Analytical strategies for LC-MS-based targeted metabolomics. (2008) (445)
- Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. (2010) (443)
- Autophagy is required for glucose homeostasis and lung tumor maintenance. (2014) (416)
- Metabolomics and Isotope Tracing (2018) (415)
- LC-MS data processing with MAVEN: a metabolomic analysis and visualization engine. (2012) (400)
- Quorum Sensing Controls Biofilm Formation in Vibrio cholerae through Modulation of Cyclic Di-GMP Levels and Repression of vpsT (2004) (385)
- Dynamics of the Cellular Metabolome during Human Cytomegalovirus Infection (2006) (368)
- The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism. (2010) (355)
- Absolute quantitation of intracellular metabolite concentrations by an isotope ratio-based approach (2008) (343)
- The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids. (2018) (342)
- Quiescent Fibroblasts Exhibit High Metabolic Activity (2010) (341)
- Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy. (2017) (339)
- Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia (2013) (334)
- Serine catabolism regulates mitochondrial redox control during hypoxia. (2014) (328)
- Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation (2012) (317)
- Enzyme clustering accelerates processing of intermediates through metabolic channeling (2014) (298)
- Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion. (2014) (294)
- Acidic acetonitrile for cellular metabolome extraction from Escherichia coli. (2007) (293)
- Quantitative Analysis of NAD Synthesis-Breakdown Fluxes. (2018) (287)
- Divergent Effects of Human Cytomegalovirus and Herpes Simplex Virus-1 on Cellular Metabolism (2011) (281)
- Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells (2016) (278)
- Metabolite concentrations, fluxes, and free energies imply efficient enzyme usage (2016) (275)
- Host-parasite interactions revealed by Plasmodium falciparum metabolomics. (2009) (272)
- Conservation of the metabolomic response to starvation across two divergent microbes (2006) (259)
- Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway. (2016) (258)
- Kinetic flux profiling for quantitation of cellular metabolic fluxes (2008) (255)
- Itaconic acid is a mammalian metabolite induced during macrophage activation. (2011) (250)
- Metabolite Measurement: Pitfalls to Avoid and Practices to Follow. (2017) (248)
- A branched chain amino acid metabolite drives vascular transport of fat and causes insulin resistance (2016) (247)
- Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. (2016) (241)
- Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. (2016) (233)
- Growth-limiting Intracellular Metabolites in Yeast Growing under Diverse Nutrient Limitations (2010) (233)
- Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors (2016) (230)
- Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation (2018) (229)
- Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate (2020) (227)
- Systems-level analysis of mechanisms regulating yeast metabolic flux (2016) (226)
- Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids. (2019) (226)
- Autophagy maintains tumor growth through circulating arginine (2018) (224)
- Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity (2020) (224)
- α-ketoglutarate coordinates carbon and nitrogen utilization via Enzyme I inhibition (2011) (215)
- Cancer-associated IDH1 mutations produce 2-hydroxyglutarate (2010) (209)
- Metabolic control of methylation and acetylation. (2016) (204)
- Four Key Steps Control Glycolytic Flux in Mammalian Cells. (2018) (204)
- Lactate: the ugly duckling of energy metabolism (2020) (200)
- Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production. (2016) (194)
- As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid. (2018) (186)
- Restoring metabolism of myeloid cells reverses cognitive decline in ageing (2021) (175)
- Comprehensive quantification of fuel use by the failing and nonfailing human heart (2020) (174)
- Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate (2014) (172)
- Specific Control of Pseudomonas aeruginosa Surface-Associated Behaviors by Two c-di-GMP Diguanylate Cyclases (2010) (171)
- Metabolomics-driven quantitative analysis of ammonia assimilation in E. coli (2009) (167)
- Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation. (2015) (161)
- Mitochondrial translation requires folate-dependent tRNA methylation (2018) (160)
- Metabolite Spectral Accuracy on Orbitraps. (2017) (158)
- Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria. (2007) (157)
- Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli (2010) (152)
- Yeast cells can access distinct quiescent states. (2011) (152)
- Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate (2014) (146)
- Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma (2017) (143)
- Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition (2012) (141)
- Ammonium Toxicity and Potassium Limitation in Yeast (2006) (139)
- Avoiding misannotation of in-source fragmentation products as cellular metabolites in liquid chromatography-mass spectrometry-based metabolomics. (2015) (137)
- Serine Metabolism Supports Macrophage IL-1β Production. (2019) (135)
- Cyclic-di-GMP-Mediated Repression of Swarming Motility by Pseudomonas aeruginosa: the pilY1 Gene and Its Impact on Surface-Associated Behaviors (2010) (129)
- Systems-Level Metabolic Flux Profiling Elucidates a Complete, Bifurcated Tricarboxylic Acid Cycle in Clostridium acetobutylicum (2010) (129)
- Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling (2017) (128)
- A high-performance liquid chromatography-tandem mass spectrometry method for quantitation of nitrogen-containing intracellular metabolites (2006) (127)
- A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance (2020) (124)
- Metabolomics in systems microbiology. (2011) (121)
- Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function. (2015) (119)
- Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes (2018) (119)
- Absence of Detectable Arsenate in DNA from Arsenate-Grown GFAJ-1 Cells (2012) (118)
- The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA (2009) (117)
- Kinetic flux profiling of nitrogen assimilation in Escherichia coli (2006) (117)
- Metabolome Remodeling during the Acidogenic-Solventogenic Transition in Clostridium acetobutylicum (2011) (117)
- Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function (2019) (116)
- The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine. (2021) (113)
- Metabolite Exchange between Mammalian Organs Quantified in Pigs. (2019) (109)
- A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate. (2019) (108)
- A domino effect in antifolate drug action in Escherichia coli. (2008) (105)
- Glucose becomes one of the worst carbon sources for E.coli on poor nitrogen sources due to suboptimal levels of cAMP (2016) (103)
- CD38 ecto-enzyme in immune cells is induced during aging regulating NAD+ and NMN levels (2020) (103)
- Coordinated Concentration Changes of Transcripts and Metabolites in Saccharomyces cerevisiae (2009) (103)
- Nicotinamide adenine dinucleotide is transported into mammalian mitochondria (2018) (103)
- Riboneogenesis in Yeast (2011) (102)
- SLC25A51 is a mammalian mitochondrial NAD+ transporter (2020) (102)
- NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism (2019) (99)
- Survival of starving yeast is correlated with oxidative stress response and nonrespiratory mitochondrial function (2011) (99)
- Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunity. (2014) (97)
- Serine Catabolism Feeds NADH when Respiration Is Impaired. (2020) (95)
- Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress (2011) (94)
- Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1. (2007) (94)
- Extraction and Quantitation of Nicotinamide Adenine Dinucleotide Redox Cofactors. (2018) (93)
- Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage. (2016) (93)
- Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity (2020) (89)
- Quantitative fluxomics of circulating metabolites (2020) (87)
- Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolism. (2011) (86)
- Rapidly Proliferating Cells Evidence for an Alternative Glycolytic Pathway in (2010) (86)
- Pyrimidine homeostasis is accomplished by directed overflow metabolism (2013) (85)
- Saturated Very Long Chain Fatty Acids Are Required for the Production of Infectious Human Cytomegalovirus Progeny (2013) (85)
- The Tumor Metabolic Microenvironment: Lessons from Lactate. (2019) (85)
- T Cell Activation Depends on Extracellular Alanine. (2019) (83)
- Branched Tricarboxylic Acid Metabolism in Plasmodium falciparum (2010) (83)
- Identifying decomposition products in extracts of cellular metabolites. (2006) (82)
- Escherichiacoli translation strategies differ across carbon, nitrogen and phosphorus limitation conditions (2018) (82)
- mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1. (2016) (77)
- Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase (2012) (76)
- Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection (2012) (76)
- Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice (2018) (76)
- Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion (2016) (75)
- Peripheral TREM1 responses to brain and intestinal immunogens amplify stroke severity (2019) (75)
- Cellular metabolomics of Escherchia coli (2007) (74)
- The hepatocyte clock and feeding control chronophysiology of multiple liver cell types (2020) (73)
- Antifolate-induced depletion of intracellular glycine and purines inhibits thymineless death in E. coli. (2010) (72)
- Fatty Acid Elongase 7 Catalyzes the Lipidome Remodeling Essential for Human Cytomegalovirus Replication (2015) (72)
- Steady-State Metabolite Concentrations Reflect a Balance between Maximizing Enzyme Efficiency and Minimizing Total Metabolite Load (2013) (72)
- Characterizing the in vivo role of trehalose in Saccharomyces cerevisiae using the AGT1 transporter (2015) (70)
- Metabolomics in drug target discovery. (2011) (70)
- Fatty Acid Labeling from Glutamine in Hypoxia Can Be Explained by Isotope Exchange without Net Reductive Isocitrate Dehydrogenase (IDH) Flux (2013) (67)
- Biclustering via optimal re-ordering of data matrices in systems biology: rigorous methods and comparative studies (2008) (66)
- Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice (2018) (66)
- mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein. (2017) (66)
- The small intestine shields the liver from fructose-induced steatosis (2020) (63)
- Herpes Simplex Virus 1 Infection Activates Poly(ADP-Ribose) Polymerase and Triggers the Degradation of Poly(ADP-Ribose) Glycohydrolase (2012) (63)
- Mass spectrometry-based metabolomics of yeast. (2010) (62)
- Fast Onset Medications through Thermally Generated Aerosols (2004) (61)
- Treatment of Pancreatic Cancer Patient–Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin (2017) (61)
- Remodeling of the Metabolome during Early Frog Development (2011) (60)
- Robustness in Glyoxylate Bypass Regulation (2009) (60)
- Regulation of yeast pyruvate kinase by ultrasensitive allostery independent of phosphorylation. (2012) (59)
- Chemical Basis for Deuterium Labeling of Fat and NADPH. (2017) (59)
- Robust control of nitrogen assimilation by a bifunctional enzyme in E. coli. (2011) (58)
- NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism (2019) (57)
- A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway (2020) (57)
- Nucleotide degradation and ribose salvage in yeast (2013) (57)
- Branched tricarboxylic acid metabolism in Plasmodium falciparum (2011) (57)
- Peak Annotation and Verification Engine for Untargeted LC-MS Metabolomics. (2018) (56)
- Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP. (2016) (55)
- Ultra-fast absorption of amorphous pure drug aerosols via deep lung inhalation. (2006) (55)
- Isotope ratio-based profiling of microbial folates (2007) (53)
- Genetic Basis of Metabolome Variation in Yeast (2014) (52)
- Metabolite discovery through global annotation of untargeted metabolomics data (2021) (51)
- Di-Adenosine Tetraphosphate (Ap4A) Metabolism Impacts Biofilm Formation by Pseudomonas fluorescens via Modulation of c-di-GMP-Dependent Pathways (2010) (49)
- RpoS proteolysis is controlled directly by ATP levels in Escherichia coli. (2012) (49)
- SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia (2020) (48)
- Near-equilibrium glycolysis supports metabolic homeostasis and energy yield (2019) (47)
- RNA Futile Cycling in Model Persisters Derived from MazF Accumulation (2015) (46)
- Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response (2020) (45)
- Achieving Optimal Growth through Product Feedback Inhibition in Metabolism (2010) (45)
- Targeting hepatic glutaminase activity to ameliorate hyperglycemia (2018) (44)
- Hierarchy in Pentose Sugar Metabolism in Clostridium acetobutylicum (2014) (43)
- Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells (2020) (43)
- The Source of Glycolytic Intermediates in Mammalian Tissues. (2021) (42)
- Quantitation of cellular metabolic fluxes of methionine. (2014) (42)
- Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism (2020) (41)
- Erratum: Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway (Cell Metabolism (2016) 23(6) (1140–1153)(S1550413116301681)(10.1016/j.cmet.2016.04.016)) (2016) (40)
- Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate (2017) (40)
- Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport. (2017) (39)
- PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism. (2019) (38)
- Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infection (2013) (38)
- A comprehensive genome-scale model for Rhodosporidium toruloides IFO0880 accounting for functional genomics and phenotypic data (2019) (34)
- An LC-MS chemical derivatization method for the measurement of five different one-carbon states of cellular tetrahydrofolate (2017) (33)
- The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled) (2019) (33)
- Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae. (2013) (32)
- Natural human genetic variation determines basal and inducible expression of PM20D1, an obesity-associated gene (2019) (31)
- Teaching the design principles of metabolism. (2012) (30)
- Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy (2019) (29)
- Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation. (2020) (28)
- Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis. (2016) (28)
- Spatially resolved isotope tracing reveals tissue metabolic activity (2022) (28)
- Metabolism: Cancer mistunes methylation. (2013) (28)
- Diverse metabolic model parameters generate similar methionine cycle dynamics. (2008) (27)
- Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design (2020) (27)
- Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction. (2022) (26)
- mTORC1 promotes cell growth via m6A-dependent mRNA degradation. (2021) (26)
- Systems biology: Metabolite turns master regulator (2013) (26)
- Dynamic Control of dNTP Synthesis in Early Embryos. (2017) (24)
- Energy budget of Drosophila embryogenesis (2019) (24)
- PDK4 Inhibits Cardiac Pyruvate Oxidation in Late Pregnancy (2017) (23)
- A systematic genetic screen for genes involved in sensing inorganic phosphate availability in Saccharomyces cerevisiae (2017) (23)
- Characteristic Phenotypes Associated with ptsN-Null Mutants in Escherichia coli K-12 Are Absent in Strains with Functional ilvG (2011) (23)
- Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition (2021) (23)
- NAD+ flux is maintained in aged mice despite lower tissue concentrations. (2021) (23)
- A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism. (2019) (22)
- MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. (2021) (22)
- Recirculatory Pharmacokinetic Model of the Uptake, Distribution, and Bioavailability of Prochlorperazine Administered as a Thermally Generated Aerosol in a Single Breath to Dogs (2007) (22)
- Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway. (2016) (22)
- Gut bacterial nutrient preferences quantified in vivo (2022) (21)
- Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain (2018) (21)
- Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras–Driven Tumor Growth or Metastasis (2020) (21)
- Local production of lactate, ribose phosphate, and amino acids within human triple-negative breast cancer. (2021) (20)
- MTHFD2 is a Metabolic Checkpoint Controlling Effector and Regulatory T Cell Fate and Function (2021) (19)
- Descriptor-free molecular discovery in large libraries by adaptive substituent reordering. (2008) (18)
- Dissecting enzyme regulation by multiple allosteric effectors: nucleotide regulation of aspartate transcarbamoylase. (2008) (18)
- Serine catabolism generates liver NADPH and supports hepatic lipogenesis (2021) (18)
- Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth. (2022) (16)
- A metabolic strategy to reverse fibrosis? (2019) (16)
- Epithelial and mesenchymal prostate cancer cell population dynamics on a complex drug landscape. (2017) (16)
- Biochemical and Structural Studies of Conserved Maf Proteins Revealed Nucleotide Pyrophosphatases with a Preference for Modified Nucleotides (2013) (16)
- Improved annotation of untargeted metabolomics data through buffer modifications that shift adduct mass and intensity. (2020) (16)
- Downregulation of the tyrosine degradation pathway extends Drosophila lifespan (2020) (15)
- Differentiating metabolites formed from de novo synthesis versus macromolecule decomposition. (2007) (14)
- 5,10-methenyltetrahydrofolate synthetase deficiency causes a neurometabolic disorder associated with microcephaly, epilepsy, and cerebral hypomyelination. (2018) (14)
- Circulating metabolite homeostasis achieved through mass action (2022) (14)
- NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma. (2021) (14)
- Quantitative flux analysis in mammals (2021) (14)
- Retraction: Branched tricarboxylic acid metabolism in Plasmodium falciparum (2013) (14)
- A network flow model for biclustering via optimal re-ordering of data matrices (2010) (14)
- An unexpected trigger for calorie burning in brown fat (2018) (13)
- ZMP: a master regulator of one-carbon metabolism. (2015) (12)
- Partners in the Warburg effect (2016) (12)
- Genome-scale metabolic reconstruction of the non-model yeast Issatchenkia orientalis SD108 and its application to organic acids production (2020) (11)
- Metabolic excretion associated with nutrient-growth dysregulation promotes the rapid evolution of an overt metabolic defect (2018) (11)
- Integrated landscape of cardiac metabolism in end-stage human nonischemic dilated cardiomyopathy (2022) (11)
- Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast (2018) (11)
- Estrogen-related receptor α is required for efficient human cytomegalovirus replication (2014) (10)
- Elevated Choline Kinase α–Mediated Choline Metabolism Supports the Prolonged Survival of TRAF3-Deficient B Lymphocytes (2019) (10)
- The Effect of Film Thickness on Thermal Aerosol Generation (2007) (9)
- SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma. (2020) (9)
- Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors. (2021) (8)
- Systems-Level Metabolic Flux Profiling Elucidates a Complete, Bifurcated Tricarboxylic Acid Cycle in Clostridium acetobutylicum (2011) (8)
- Enhancing molecular discovery using descriptor‐free rearrangement clustering techniques for sparse data sets (2009) (8)
- Monitoring mammalian mitochondrial translation with MitoRiboSeq (2021) (8)
- Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure. (2021) (8)
- Minor Isozymes Tailor Yeast Metabolism to Carbon Availability (2018) (8)
- Inhibition of de novo pyrimidine synthesis augments Gemcitabine induced growth inhibition in an immunocompetent model of pancreatic cancer (2021) (8)
- Metabolic excretion associated with nutrient–growth dysregulation promotes the rapid evolution of an overt metabolic defect (2020) (8)
- Autophagy maintains tumour growth through circulating arginine (2018) (7)
- GCN2 adapts protein synthesis to scavenging-dependent growth. (2021) (7)
- Slow TCA flux implies low ATP production in tumors (2021) (7)
- Integrated omics approaches to characterize a nuclear receptor corepressor-associated histone deacetylase in mouse skeletal muscle (2017) (7)
- Discovery and Functional Characterization of a Yeast Sugar Alcohol Phosphatase. (2018) (7)
- G6PD-mediated increase in de novo NADP+ biosynthesis promotes antioxidant defense and tumor metastasis (2022) (6)
- Slow TCA flux and ATP production in primary solid tumours but not metastases (2023) (6)
- Glucose feeds the tricarboxylic acid cycle via excreted ethanol in fermenting yeast (2022) (6)
- Methionine synthase supports tumor tetrahydrofolate pools (2020) (6)
- The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth (2016) (6)
- Rapid evolution of an overt metabolic defect restores balanced growth (2018) (5)
- A genetic model of methionine restriction extends Drosophila health- and lifespan (2021) (5)
- CAR T-Cells Depend on the Coupling of NADH Oxidation with ATP Production (2021) (5)
- Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate and promotes histone methylation (2014) (4)
- Live-Cell Imaging of NADPH Production from Specific Pathways (2020) (4)
- E. coli translation strategies differ across nutrient conditions (2018) (4)
- Metabolomics of Clostridial Biofuel Production (2015) (4)
- LC-MS and GC-MS based metabolomics platform for cancer research (2014) (4)
- Myeloid-derived itaconate suppresses cytotoxic CD8+ T cells and promotes tumour growth. (2022) (4)
- Novel media formulations to enhance Chimeric Antigen Receptor (CAR) T-cell potency and anti-tumor cell function for adoptive immunotherapy (2020) (3)
- Ribosomes on the night shift (2018) (3)
- Late-gestation maternal dietary methyl donor and cofactor supplementation in sheep partially reverses protection against allergic sensitization by IUGR. (2018) (3)
- Abstract 2953: Rev-erbα modulates Myc-driven cancer cell growth and altered metabolism (2014) (3)
- Abstract 33: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate (2010) (3)
- Author response: Nicotinamide adenine dinucleotide is transported into mammalian mitochondria (2018) (3)
- A tps1Δ persister-like state in Saccharomyces cerevisiae is regulated by MKT1 (2020) (2)
- Publisher Correction: Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response (2021) (2)
- Quantification of NADPH balance during adipogenesis (2014) (2)
- Metabolic decisions in development and disease—a Keystone Symposia report (2021) (2)
- Author Correction: Autophagy maintains tumour growth through circulating arginine (2018) (2)
- Integration of Carbon, Nitrogen, and Oxygen Metabolism in Escherichia coli (2012) (2)
- Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia (2018) (2)
- Ras-driven cancer cells can scavenge exogenous lipids to support their proliferation (2012) (2)
- Proteome capacity constraints favor respiratory ATP generation (2022) (2)
- Fatty acid depletion is a reversible cause of kynurenine induced T cell apoptosis (2019) (1)
- Quantitative flux analysis reveals folate-dependent NADPH production (2014) (1)
- Comparative study of two Saccharomyces cerevisiae strains with kinetic models at genome-scale. (2023) (1)
- LC-MS and GC-MS based metabolomics platform for cancer research (2014) (1)
- ZIP-5/bZIP transcription factor regulation of folate metabolism is critical for aging axon regeneration (2019) (1)
- An evolutionary module in central metabolism (2017) (1)
- Nicotinamide adenine dinucleotide (NAD) oxidation preserves T cell function under lactic acidosis characteristic of the tumor microenvironment (TME) (2018) (1)
- Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia. (2020) (1)
- A dual-mechanism antibiotic targets Gram-negative bacteria and avoids drug resistance (2020) (1)
- Metabolite Exchange between Mammalian Organs Quantified in Pigs. (2022) (1)
- Resource Chemical Genetics of Rapamycin-Insensitive TORC 2 in S . cerevisiae (2013) (1)
- Biclustering of data matrices in systems biology via optimal re-ordering (2008) (1)
- Transcriptional and Metabolic Profiling of Nicotinamide-Enhanced Natural Killer (NAM-NK) Cells (GDA-201) (2021) (1)
- Immunosuppression reverse engineered from cancer: Reducing nicotinamide adenine dinucleotide (NAD) impairs effector T cell function through glycolysis (2018) (1)
- NAD+ flux is maintained in aged mice (2020) (1)
- Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function (2019) (1)
- Impaired Lymphocyte Responses in Pediatric Sepsis Vary by Pathogen Type and are Associated with Features of Immunometabolic Dysregulation (2021) (1)
- OPTIMAL METHODS FOR RE-ORDERING DATA MATRICES IN SYSTEMS BIOLOGY AND DRUG DISCOVERY APPLICATIONS (2008) (1)
- Photoproximity Labeling of Sialylated Glycoproteins (GlycoMap) Reveals Sialylation-Dependent Regulation of Ion Transport. (2022) (1)
- Erratum: Branched tricarboxylic acid metabolism in Plasmodium falciparum (Nature (2010) 466 (774-778)) (2011) (1)
- Selenium modulates cancer cell response to pharmacologic ascorbate. (2022) (1)
- Quantitative Tools for Dissection of Hydrogen-Producing Metabolic Networks-Final Report (2012) (0)
- Opioids supply through an inhalation route. (2002) (0)
- Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia (2018) (0)
- Method of forming an aerosol for inhalation administration. (2002) (0)
- SLC25A51 is a mammalian mitochondrial NAD+ transporter (2020) (0)
- Glycine homeostasis requires reverse SHMT flux (2023) (0)
- Procedure and apparatus for vaporizing a compound. (2003) (0)
- Final Technical Report--Quantitative analysis of metabolic regulation by integration of metabolomics, proteomics, and fluxomics (2018) (0)
- Metabolic and Deep Immune Profiling Reveal Coordinate Effects on Immune Function in Asthma and Obesity (2017) (0)
- A two-enzyme adaptive unit in bacterial folate metabolism (2018) (0)
- Abstract 1150: mTORC2 enhances flux through the hexosamine biosynthetic pathway by regulation of GFAT1 expression (2015) (0)
- Comprehensive quantitation of metabolite concentrations, gross reaction fluxes, and reaction free energies across cells from four organisms (2014) (0)
- Administration of alprazolam, estazolam, midazolam or triazolam through an inhalation. (2002) (0)
- NADK is Activated by Oncogenic KRAS Signaling to Sustain Pancreatic Ductal Adenocarcinoma (2020) (0)
- Metabolite turns master regulator The phenomenon of catabolite repression enables microorganisms to use their favourite carbon source first. New work reveals α-ketoacids as key effectors of this process, with their levels regulating gene expression. See Article p.301 (2013) (0)
- The small intestine shields the liver from fructose-induced steatosis (2020) (0)
- Correction: Novel Pyrrolo[3,2-d]Pyrimidine Compounds Target Mitochondrial and Cytosolic One-Carbon Metabolism with Broad-spectrum Antitumor Efficacy. (2023) (0)
- Abstract 2441: mTOR complex 2 modulates glycosylation of CD147 via the hexosamine biosynthetic pathway (2014) (0)
- Abstract CT163: A Phase Ib/II trial of high dose ascorbic acid (AA) + paclitaxel protein bound (PP) + cisplatin (C) + gemcitabine (G) in patients (pts) with metastatic pancreatic cancer (MPC) (2019) (0)
- Comprehensive quantitation of metabolite concentrations, gross reaction fluxes, and reaction free energies across cells from four organisms (2014) (0)
- Mechanisms by which Obesity Dysregulates Immunometabolic State in Asthma (2020) (0)
- The regulation of ribosome efficiency by nutrients and growth (0)
- of TRAF3-Deficient B Lymphocytes Metabolism Supports the Prolonged Survival Mediated Choline - a Elevated Choline Kinase (0)
- Abstract 562: Comprehensive Arteriovenous Metabolomics in the Human Heart (2019) (0)
- Abstract LB-61: Targeting cancer cell metabolism in pancreatic cancer: p53, a key regulator of glycolysis and a major factor deciding the outcome of targeting the Warburg effect (2012) (0)
- Abstract 4709: Compartmental flexibility in mammalian folate metabolism (2015) (0)
- Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate (2014) (0)
- Abstract B27: A phase Ib/II trial of high-dose (HD) ascorbic acid (AA) + paclitaxel protein bound (PP) + cisplatin (C) + gemcitabine (G) in patients (pts) with metastatic pancreatic cancer (MPC) (2019) (0)
- Metabolic engineering of low-pH-tolerant non-model yeast, Issatchenkia orientalis, for production of citramalate (2023) (0)
- Author Correction: Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function (2019) (0)
- Quorum Sensing Controls Biofilm Formation in Vibrio cholerae through Modulation of Cyclic Di-GMP Levels and Repression of vpsT (cid:1) (2008) (0)
- Abstract 2992: Cellular pharmacodynamics of mitochondrial one-carbon metabolism-targeting 5-substituted pyrrolo[3,2-d]pyrimidine antifolates (2019) (0)
- Administration of drugs for the treatment of erectile dysfunction by inhalation (2002) (0)
- Release of antipsytics by inhalatory route. (2002) (0)
- Serine catabolism generates NADPH to support hepatic lipogenesis (2021) (0)
- Cell death induced by autophagy and mTOR inhibition is RIPK-dependent necroptosis. (2012) (0)
- Towards a comprehensive understanding of cellular metabolism (2013) (0)
- An unexpected trigger for calorie burning in brown fat (2018) (0)
- Partners in the Warburg effect Cells that surround tumors produce vesicles that supply nutrients to cancer cells and, more surprisingly, also impair the generation of energy in these cancer cells. (2016) (0)
- 4582 NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD) DEPLETION MUST BE SEVERE TO INDUCE CARDIAC DYSFUNCTION AND EVENTUAL FAILURE (2020) (0)
- Fatty acid metabolism is essential to maintain functions of CD8+T cells within a hypoxic and hypoglycemic tumor microenvironment (2016) (0)
- MON-LB017 Natural Genetic Variation in Humans Determines Basal and PPAR-Inducible Expression of PM20D1, a Putative Thermogenic Gene (2019) (0)
- Abstract 1013: Quantification of NADPH balance in cancer (2016) (0)
- Abstract 3980: Dual targeting mitochondrial and cytosolic one-carbon metabolism via the proton-coupled folate transporter with novel 5-substituted pyrrolo[3,2-d]pyrimidine antifolates (2018) (0)
- Use of Loxapine for the preparation of an agent for treating pain (2003) (0)
- Escherichiacoli translation strategies differ across carbon, nitrogen and phosphorus limitation conditions (2018) (0)
- Abstract 232: Pharmacological and genetic dissection of one carbon pathway provides novel insights into generation, transformation and utilization of one carbon units (2016) (0)
- Abstract A14: Role of mitochondrial folate metabolism in cancer cell growth and proliferation (2016) (0)
- Abstract IA12: Coordination of mRNA processing, translation, and metabolism by mTORC1 (2020) (0)
- Tissue-Specific and Interorgan Metabolic Reprogramming Maintains Tolerance to Sepsis (2022) (0)
- Abstract IA018: ATP production in pancreas cancer and tumor infiltrating lymphocytes (2022) (0)
- Administration of antipsychotics by inhalation (2002) (0)
- Crystal structure of homo sapiens serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2), in complex with glycine, PLP and folate-competitive pyrazolopyran inhibitor: 6-amino-4-isopropyl-3-methyl-4-(3-(pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile (2017) (0)
- Development of laboratory and computational techniques for optimal and quantitative understanding of cellular metabolic networks (2008) (0)
- Abstract PO-015: A phase Ib/II trial of high dose ascorbic acid (AA) + paclitaxel protein bound (PP) + cisplatin (C) + gemcitabine (G) in patients (pts) with previously untreated metastatic pancreatic cancer (MPC) (2021) (0)
- Author Correction: Autophagy maintains tumour growth through circulating arginine (2018) (0)
- Administration of opioid by inhalation (2002) (0)
- Abstract 5713: Reprogramming of serine metabolism during breast cancer progression (2020) (0)
- Substrates for drug administration apparatus and process for preparation (2004) (0)
- Substrates for a medicament administration device and method of preparation (2004) (0)
- Administration of parkinson agents anti-through inhalation (2002) (0)
- mTORC2 Regulation of the Hexosamine Biosynthetic Pathway (HBP) in Response to Nutrients (2016) (0)
- GFAJ-1 Cells Absence of Detectable Arsenate in DNA from Arsenate-Grown (2012) (0)
- An End-to-end Pipeline for Succinic Acid Production at an Industrially Relevant Scale using Issatchenkia orientalis (2023) (0)
- A metabolic strategy to reverse fibrosis? (2019) (0)
- Abstract P3-02-06: Tracing glucose catabolism in human triple negative breast cancer tumors (2020) (0)
- Systems Biology and Metabolic Engineering Approaches for Biological Hydrogen Production (2009) (0)
- coli Escherichia RpoS proteolysis is controlled directly by ATP levels in Material (2012) (0)
- Final Technical Report Integration of Carbon, Nitrogen, and Oxygen Metabolism in Escherichia Coli Afosr 17. Limitation of Abstract 18. Number of Pages 19a. Name of Responsible Person (2013) (0)
- Administration of nonsteroidal anti-inflammatory drugs by inhalation (2002) (0)
- Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation (2018) (0)
- Administration of antipsychotic agents by inhalation (2002) (0)
- Decision letter: Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma (2020) (0)
- Randomized phase II trial of two different nutritional approaches for patients receiving treatment for their advanced pancreatic cancer. (2022) (0)
- Systematic identification and characterization of novel genes in the regulation and biogenesis of photosynthetic machinery (2022) (0)
- Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate (2020) (0)
- Abstract PR05: Regulation of mRNA N6-adenosine methylation by the mTOR signaling (2020) (0)
- FSMP-17. GLOBAL METABOLOMIC PROFILING OF GLIOBLASTOMA MULTIFORME REVEALS METABOLIC VULNERABILITIES IN RESPONSE TO RADIATION THERAPY (2021) (0)
- A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression (2021) (0)
- A metabolic sum rule dictates bacterial response to short-chain fatty acid stress (2022) (0)
- Use of loxapine for the manufacture of a medicinal product for the treatment of pain. (2003) (0)
- TREATMENT OF MIGRAINE THROUGH AN WO WO 97/27804 8/1997 INHALATION ROUTE WO WO 97/36574 10/1997 WO WO 98/22170 5/1998 (2017) (0)
- Administration of antihistamines by inhalation (2002) (0)
- Administration d'esters medicamenteux par inhalation (2002) (0)
- Abstract 21: The mTORC2 target Akt is regulated in response to glutamine metabolite levels (2016) (0)
- Supply products sedative-hypnotic through an inhalation route. (2002) (0)
- Robust Control in the Nitrogen Assimilation System of E.coli (2007) (0)
- Abstract 285: Dichloroacetate as a novel pharmaceutical treatment for cancer-related fatigue in melanoma (2023) (0)
- 217 Cytotoxicity of nicotinamide enhanced natural killer cells GDA201 is based on metabolic modulation as demonstrated by artificial intelligence assisted analysis of NK cell transcriptome and metabolome (2021) (0)
- Abstract 100: Integrated Cardiac Metabolism In End-Stage Human Heart Failure (2021) (0)
- Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance (2023) (0)
- Circulating metabolite homeostasis achieved through mass action (2022) (0)
- Integrated cardiac metabolism in end-stage human heart failure (2022) (0)
- Release of antiemetics by the inhalation route (2002) (0)
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What Schools Are Affiliated With Joshua D Rabinowitz?
Joshua D Rabinowitz is affiliated with the following schools:
