Judith Campisi
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Why Is Judith Campisi Influential?
(Suggest an Edit or Addition)According to Wikipedia, Judith Campisi is an American biochemist and cell biologist. She is a professor of biogerontology at the Buck Institute for Research on Aging. She is also a member of the SENS Research Foundation Advisory Board and an adviser at the Lifeboat Foundation. She is co-editor in chief of the Aging Journal, together with Mikhail Blagosklonny and David Sinclair, and founder of the pharmaceutical company Unity Biotechnology. She is listed in Who's Who in Gerontology. She is widely known for her research on how senescent cells influence aging and cancer — in particular the Senescence Associated Secretory Phenotype .
Judith Campisi's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Cellular senescence: when bad things happen to good cells (2007) (3659)
- The senescence-associated secretory phenotype: the dark side of tumor suppression. (2010) (3180)
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor (2008) (3011)
- Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. (2014) (2422)
- Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors (2005) (2166)
- Aging, cellular senescence, and cancer. (2013) (1999)
- Persistent DNA damage signaling triggers senescence-associated inflammatory cytokine secretion (2009) (1739)
- Four faces of cellular senescence (2011) (1734)
- Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging (2001) (1458)
- Chronic inflammation in the etiology of disease across the life span (2019) (1434)
- Geroscience: Linking Aging to Chronic Disease (2014) (1391)
- Reversal of human cellular senescence: roles of the p53 and p16 pathways (2003) (1244)
- Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. (2013) (1204)
- An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. (2014) (1187)
- Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo (2009) (1182)
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice (2015) (1122)
- Inflammatory networks during cellular senescence: causes and consequences. (2010) (1084)
- Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts (2003) (1082)
- Cellular Senescence: Defining a Path Forward (2019) (1017)
- Cellular senescence as a tumor-suppressor mechanism. (2001) (879)
- Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging (2017) (877)
- Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment (2017) (849)
- A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells (2009) (793)
- p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype (2011) (744)
- MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation (2015) (731)
- Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. (2017) (717)
- Senescent intimal foam cells are deleterious at all stages of atherosclerosis (2016) (715)
- Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B (2012) (668)
- Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation (1984) (658)
- Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype. (2016) (652)
- Lamin B1 loss is a senescence-associated biomarker (2012) (621)
- Expression of microRNA-146 suppresses NF-κB activity with reduction of metastatic potential in breast cancer cells (2008) (614)
- The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4 (2015) (612)
- Aging and Genome Maintenance: Lessons from the Mouse? (2003) (576)
- Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation (2004) (571)
- Senescence and apoptosis: dueling or complementary cell fates? (2014) (569)
- TIN2, a new regulator of telomere length in human cells (1999) (560)
- Senescent cells as a source of inflammatory factors for tumor progression (2010) (534)
- Secretion of Vascular Endothelial Growth Factor by Primary Human Fibroblasts at Senescence* (2006) (505)
- The biology of replicative senescence. (1997) (503)
- From discoveries in ageing research to therapeutics for healthy ageing (2019) (499)
- Cell surface-bound IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network (2009) (481)
- Cancer and ageing: rival demons? (2003) (479)
- A proteomic atlas of senescence-associated secretomes for aging biomarker development (2019) (477)
- Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts. (1990) (457)
- Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication. (1998) (457)
- Control of the Replicative Life Span of Human Fibroblasts by p16 and the Polycomb Protein Bmi-1 (2003) (455)
- Replicative Senescence: An Old Lives' Tale? (1996) (451)
- DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion (2011) (441)
- MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8 (2009) (439)
- Regulation of a Senescence Checkpoint Response by the E2F1 Transcription Factor and p14ARF Tumor Suppressor (2000) (434)
- Unmasking Transcriptional Heterogeneity in Senescent Cells (2017) (429)
- The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease (1998) (428)
- Methods to detect biomarkers of cellular senescence: the senescence-associated beta-galactosidase assay. (2007) (413)
- Cancer, aging and cellular senescence. (2000) (396)
- Cellular senescence: a link between cancer and age-related degenerative disease? (2011) (384)
- The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. (2002) (379)
- Cellular senescence, cancer and aging: the telomere connection (2001) (377)
- Puzzles, promises and a cure for ageing (2008) (376)
- Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype* (2011) (372)
- A Human-Like Senescence-Associated Secretory Phenotype Is Conserved in Mouse Cells Dependent on Physiological Oxygen (2010) (367)
- Regulation of cellular senescence by p53. (2001) (364)
- Two faces of p53: aging and tumor suppression (2007) (355)
- Ku acts in a unique way at the mammalian telomere to prevent end joining. (2000) (351)
- Mechanisms of cellular senescence in human and mouse cells (2004) (341)
- Cellular senescence: putting the paradoxes in perspective. (2011) (339)
- Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. (1994) (330)
- Cancer and aging: a model for the cancer promoting effects of the aging stroma. (2002) (328)
- Targeting senescent cells alleviates obesity‐induced metabolic dysfunction (2019) (311)
- p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes (2011) (305)
- Aging of the immune system: Focus on inflammation and vaccination (2016) (297)
- Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease (2018) (281)
- Regulation and Localization of the Bloom Syndrome Protein in Response to DNA Damage (2001) (278)
- From cells to organisms: can we learn about aging from cells in culture? (2001) (269)
- Suppressing Cancer: The Importance of Being Senescent (2005) (264)
- From Ancient Pathways to Aging Cells-Connecting Metabolism and Cellular Senescence. (2016) (254)
- A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells. (2000) (251)
- TIN2 Mediates Functions of TRF2 at Human Telomeres* (2004) (245)
- Telomeres, aging and cancer: In search of a happy ending (2002) (244)
- Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9. (2000) (238)
- TANK2, a New TRF1-associated Poly(ADP-ribose) Polymerase, Causes Rapid Induction of Cell Death upon Overexpression* (2001) (234)
- Regulation of c-myc transcription and mRNA abundance by serum growth factors and cell contact. (1986) (232)
- Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition (2019) (221)
- Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase. (2001) (216)
- Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin (2012) (212)
- The role of inflammation in age-related disease (2013) (209)
- Aging and Cancer: The Double‐Edged Sword of Replicative Senescence (1997) (208)
- Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type beta transforming growth factor. (2000) (207)
- Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes (2003) (203)
- Epithelial-Mesenchymal Transition Induced by Senescent Fibroblasts (2012) (203)
- Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture (2003) (200)
- Cell senescence: role in aging and age-related diseases. (2014) (195)
- The role of cellular senescence in skin aging. (1998) (195)
- Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein Id-1 (1995) (195)
- Time to Talk SENS: Critiquing the Immutability of Human Aging (2002) (195)
- Cellular senescence and the aging brain (2015) (194)
- Glucocorticoids suppress selected components of the senescence‐associated secretory phenotype (2012) (170)
- Aging, tumor suppression and cancer: high wire-act! (2004) (163)
- A Novel Pathway for Mammary Epithelial Cell Invasion Induced by the Helix-Loop-Helix Protein Id-1 (1998) (163)
- Senescent cells and osteoarthritis: a painful connection (2018) (154)
- Zinc-finger protein-targeted gene regulation: Genomewide single-gene specificity (2003) (153)
- Characterization of the human and mouse WRN 3'-->5' exonuclease. (2000) (151)
- Cell Senescence Abrogates the Therapeutic Potential of Human Mesenchymal Stem Cells in the Lethal Endotoxemia Model (2014) (149)
- Analysis of individual cells identifies cell‐to‐cell variability following induction of cellular senescence (2017) (148)
- Inhibition of E2F activity by the cyclin-dependent protein kinase inhibitor p21 in cells expressing or lacking a functional retinoblastoma protein (1996) (143)
- c-myc regulation during retinoic acid-induced differentiation of F9 cells is posttranscriptional and associated with growth arrest (1986) (139)
- Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages (2020) (138)
- Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice (2019) (135)
- Oncogene-Induced Senescence Pathways Weave an Intricate Tapestry (2007) (135)
- Restriction point control of cell growth by a labile protein: evidence for increased stability in transformed cells. (1982) (134)
- Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease? (2013) (133)
- Regulation of two E2F-related genes in presenescent and senescent human fibroblasts. (1994) (129)
- WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair (2003) (129)
- Ionizing radiation‐induced long‐term expression of senescence markers in mice is independent of p53 and immune status (2010) (129)
- Induction of c-fos and c-myc mRNA by epidermal growth factor or calcium ionophore is cAMP dependent. (1986) (127)
- Cancer and aging: the importance of telomeres in genome maintenance. (2005) (126)
- Targeted Quantitation of Site-Specific Cysteine Oxidation in Endogenous Proteins Using a Differential Alkylation and Multiple Reaction Monitoring Mass Spectrometry Approach (2010) (123)
- Role of immune cells in the removal of deleterious senescent cells (2020) (121)
- Context-dependent effects of cellular senescence in cancer development (2016) (118)
- Heparin suppresses the induction of c-fos and c-myc mRNA in murine fibroblasts by selective inhibition of a protein kinase C-dependent pathway. (1989) (115)
- Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity (2020) (114)
- Placental membrane aging and HMGB1 signaling associated with human parturition (2016) (110)
- Ageing: Balancing regeneration and cancer (2006) (108)
- A Role for p53 in Maintaining and Establishing the Quiescence Growth Arrest in Human Cells* (2002) (107)
- Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress. (2004) (106)
- The Demographic and Biomedical Case for Late-Life Interventions in Aging (2010) (106)
- Post-transcriptional control of the onset of DNA synthesis by an insulin-like growth factor (1984) (105)
- Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks (2003) (101)
- Senescent cells and their secretory phenotype as targets for cancer therapy. (2013) (98)
- Whole Chromosome Instability induces senescence and promotes SASP (2016) (97)
- Id-1, ITF-2, and Id-2 Comprise a Network of Helix-Loop-Helix Proteins That Regulate Mammary Epithelial Cell Proliferation, Differentiation, and Apoptosis* (2001) (97)
- Reversible Manipulation of Telomerase Expression and Telomere Length (2002) (95)
- Astrocyte senescence promotes glutamate toxicity in cortical neurons (2020) (94)
- Lack of WRN results in extensive deletion at nonhomologous joining ends. (2002) (93)
- Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links (2006) (92)
- Does damage to DNA and other macromolecules play a role in aging? If so, how? (2009) (91)
- Replicative senescence and cell death. (1995) (91)
- Replication Timing of Human Telomeres Is Chromosome Arm–Specific, Influenced by Subtelomeric Structures and Connected to Nuclear Localization (2010) (91)
- The metabolic roots of senescence: mechanisms and opportunities for intervention (2021) (89)
- SKI Activates Wnt/-Catenin Signaling in Human Melanoma1 (2003) (89)
- Cell Autonomous and Non-autonomous Effects of Senescent Cells in the Skin (2015) (88)
- Telomere-Associated Protein TIN2 Is Essential for Early Embryonic Development through a Telomerase-Independent Pathway (2004) (87)
- Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy (2021) (86)
- Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors. (2019) (86)
- Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype (2018) (86)
- Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference (2005) (85)
- Molecular and cell biology of replicative senescence. (1994) (85)
- Disease drivers of aging (2016) (84)
- The thorny path linking cellular senescence to organismal aging (2005) (84)
- Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells (2017) (84)
- Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing (2015) (83)
- Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging. (2019) (83)
- Of flies, mice, and men: evolutionarily conserved tissue damage responses and aging. (2015) (80)
- Two independent growth factor-generated signals regulate c-fos and c-myc mRNA levels in Swiss 3T3 cells. (1987) (79)
- Replicative senescence, aging and growth-regulatory transcription factors. (1996) (79)
- Oxidation resistance 1 is a novel senolytic target (2018) (78)
- The helix-loop-helix protein Id-1 and a retinoblastoma protein binding mutant of SV40 T antigen synergize to reactivate DNA synthesis in senescent human fibroblasts. (1996) (77)
- Regulation of c‐fos expression in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors (1995) (77)
- Simvastatin suppresses breast cancer cell proliferation induced by senescent cells (2015) (76)
- SKI activates Wnt/beta-catenin signaling in human melanoma. (2003) (74)
- Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers. (2019) (73)
- Aging and cancer cell biology, 2009 (2009) (73)
- A Role for Fibroblasts in Mediating the Effects of Tobacco-Induced Epithelial Cell Growth and Invasion (2008) (72)
- IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis. (2020) (72)
- Mitochondrial DNA damage induces apoptosis in senescent cells (2013) (72)
- miR‐335 Correlates with Senescence/Aging in Human Mesenchymal Stem Cells and Inhibits Their Therapeutic Actions Through Inhibition of AP‐1 Activity (2014) (71)
- Systemic clearance of p16INK4a‐positive senescent cells mitigates age‐associated intervertebral disc degeneration (2019) (71)
- Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes (2008) (70)
- Kinetics of G1 transit following brief starvation for serum factors. (1984) (70)
- Ras proteins are essential and selective for the action of insulin-like growth factor 1 late in the G1 phase of the cell cycle in BALB/c murine fibroblasts. (1992) (69)
- SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells (2019) (69)
- Altered profile of transcription factor-binding activities in senescent human fibroblasts. (1994) (67)
- mTORC1 and p53 (2013) (67)
- Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing (2012) (66)
- STAT3 can serve as a hit in the process of malignant transformation of primary cells (2012) (64)
- The human melanocyte: a model system to study the complexity of cellular aging and transformation in non-fibroblastic cells (2001) (63)
- Epithelial innate immunity mediates tubular cell senescence after kidney injury. (2019) (62)
- ATR and ATM-Dependent Movement of BLM Helicase during Replication Stress Ensures Optimal ATM Activation and 53BP1 Focus Formation (2004) (61)
- Identification of a transcript that is down-regulated in senescent human fibroblasts. Cloning, sequence analysis, and regulation of the human L7 ribosomal protein gene. (1993) (61)
- Cellular Senescence and Lung Function during Aging. Yin and Yang. (2016) (61)
- Cell biology: The beginning of the end (2013) (59)
- Cellular senescence: A reflection of normal growth control, differentiation, or aging? (1991) (59)
- Integrating epithelial cancer, aging stroma and cellular senescence. (2002) (58)
- Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2 (2004) (56)
- Hypoxia-inducible factor-1 and neuroglobin expression (2012) (55)
- Generation and Characterization of Telomere Length Maintenance in Tankyrase 2-Deficient Mice (2006) (54)
- Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis. (2019) (54)
- Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells (2015) (54)
- The human telomere‐associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro (2003) (53)
- p53: Pro-aging or pro-longevity? (2010) (53)
- Genomic Instability, Aging, and Cellular Senescence (2004) (53)
- Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD‐L1)‐mediated immunosuppression (2019) (53)
- c-ras-Ha gene expression is regulated by insulin or insulinlike growth factor and by epidermal growth factor in murine fibroblasts (1989) (52)
- Cellular Senescence and the Senescence-Associated Secretory Phenotype as Drivers of Skin Photoaging. (2020) (51)
- Alternative modes of c-myc regulation in growth factor-stimulated and differentiating cells. (1987) (51)
- Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis. (2021) (50)
- Regulation of dihydrofolate reductase gene expression and E2F components in human diploid fibroblasts during growth and senescence (1996) (49)
- C. elegans clk-2, a gene that limits life span, encodes a telomere length regulator similar to yeast telomere binding protein Tel2p (2001) (48)
- Aging and cancer cell biology, 2007 (2007) (48)
- Cellular Senescence Promotes Skin Carcinogenesis through p38MAPK and p44/42MAPK Signaling (2020) (48)
- Cellular aging and senescence. (1991) (48)
- Constitutive expression of growth-related mRNAs in proliferating and nonproliferating lung epithelial cells in primary culture: evidence for growth-dependent translational control. (1990) (48)
- A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix (2009) (47)
- Coming of age in culture (1996) (46)
- Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation–induced impairment of neurovascular coupling responses protecting cognitive function in mice (2020) (46)
- Targeted inhibition of metastatic melanoma through interference with Pin1-FOXM1 signaling (2015) (46)
- The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice (2021) (45)
- Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment. (2019) (45)
- Genomic organization, sequence, and chromosomal localization of the human helix-loop-helix Id1 gene. (1997) (43)
- Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma (2020) (43)
- The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome (2011) (43)
- Aging and cancer cell biology, 2008 (2008) (43)
- p53-dependent integration of telomere and growth factor deprivation signals (2007) (43)
- SV40 Large T Antigen Transactivates the Human cdc2 Promoter by Inducing a CCAAT Box Binding Factor* (1996) (42)
- Aging, Chromatin, and Food Restriction--Connecting the Dots (2000) (41)
- GROα regulates human embryonic stem cell self-renewal or adoption of a neuronal fate. (2011) (40)
- Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability. (2016) (40)
- How does proliferative homeostasis change with age? What causes it and how does it contribute to aging? (2009) (40)
- Quantification of epithelial cells in coculture with fibroblasts by fluorescence image analysis. (2002) (40)
- Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity (2020) (40)
- Algorithmic assessment of cellular senescence in experimental and clinical specimens (2021) (40)
- Responses of human embryonic stem cells and their differentiated progeny to ionizing radiation. (2012) (40)
- Impact papers on aging in 2009 (2010) (40)
- Cancer and aging: More puzzles, more promises? (2008) (39)
- Between Scylla and Charybdis: p53 links tumor suppression and aging (2002) (39)
- Strategies to Prevent or Remediate Cancer and Treatment-Related Aging. (2020) (37)
- Systemic clearance of p16 INK4a ‐ positive senescent cells mitigates age ‐ associated intervertebral disc degeneration (2019) (37)
- Fragile fugue: p53 in aging, cancer and IGF signaling (2004) (35)
- Cell cycle perturbations in normal and transformed fibroblasts caused by detachment from the substratum (1983) (35)
- To help aging populations, classify organismal senescence (2019) (35)
- Elimination of senescent osteoclast progenitors has no effect on the age‐associated loss of bone mass in mice (2019) (34)
- Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin (2019) (34)
- Mutant frequencies and spectra depend on growth state and passage number in cells cultured from transgenic lacZ-plasmid reporter mice. (2006) (34)
- Glass-coated ferromagnetic microwire-induced magnetic hyperthermia for in vitro cancer cell treatment. (2020) (33)
- Aging: past, present and future (2009) (33)
- Depletion of senescent-like neuronal cells alleviates cisplatin-induced peripheral neuropathy in mice (2020) (33)
- Modulation of cell growth, p34cdc2 and cyclin A levels by SV-40 large T antigen. (1993) (32)
- Oncogenic senescence: a multi-functional perspective (2017) (31)
- Fundamentals of cell proliferation: control of the cell cycle. (1991) (31)
- Caspase‐independent cytochrome c release is a sensitive measure of low‐level apoptosis in cell culture models (2005) (30)
- p16INK4a‐mediated suppression of telomerase in normal and malignant human breast cells (2010) (30)
- Cancer and aging: yin, yang, and p53. (2002) (29)
- Cellular Senescence and Lung Function during Aging (2016) (29)
- Fertilization-induced changes in membrane fluidity of sea urchin eggs. (1978) (29)
- Butyrate inhibits the retinoic acid-induced differentiation of F9 teratocarcinoma stem cells. (1984) (29)
- Calcium-induced decrease in membrane fluidity of sea urchin egg cortex after fertilization (1980) (28)
- Selective Cleavage of BLM, the Bloom Syndrome Protein, during Apoptotic Cell Death* (2001) (28)
- p53 and rapamycin are additive (2015) (27)
- Gene Expression in Quiescent and Senescent Fibroblasts (1992) (27)
- Defective Ca2+ metabolism in Duchenne muscular dystrophy: effects on cellular and viral growth. (1984) (25)
- Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response. (2008) (25)
- ARDD 2020: from aging mechanisms to interventions (2020) (25)
- ATM Suppresses SATB1-Induced Malignant Progression in Breast Epithelial Cells (2012) (23)
- The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications (2020) (23)
- Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging. (2021) (22)
- Novel mutation that causes a structural change in a lipoprotein in the outer membrane of Escherichia coli (1976) (21)
- Cdkn1a transcript variant 2 is a marker of aging and cellular senescence (2021) (21)
- Aging and drug discovery (2018) (21)
- Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung (2020) (18)
- Growth-factor-inducible gene expression in senescent human fibroblasts (1989) (17)
- KDM4 orchestrates epigenomic remodeling of senescent cells and potentiates the senescence-associated secretory phenotype (2020) (16)
- Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ pro-inflammatory macrophages (2019) (15)
- Regulation of mammary epithelial cell phenotypes by the helix-loop-helix protein, Id-1. (1999) (15)
- A direct comparison of interphase FISH versus low-coverage single cell sequencing to detect aneuploidy reveals respective strengths and weaknesses (2019) (14)
- Effect of Ku80 Deficiency on Mutation Frequencies and Spectra at a LacZ Reporter Locus in Mouse Tissues and Cells (2008) (14)
- DIFFERENCES IN GROWTH REGULATION OF NORMAL AND TUMOR CELLS * (1982) (14)
- Aging in mitotic and post-mitotic cells (2001) (14)
- Systemic induction of senescence in young mice after single heterochronic blood exchange (2022) (13)
- Mus musculus and Mus spretus homologues of the human telomere-associated protein TIN2. (2003) (13)
- MicroRNAs: An important player in maintaining a balance between inflammation and tumor suppression (2009) (13)
- Quantitative Proteomic Analysis of the Senescence‐Associated Secretory Phenotype by Data‐Independent Acquisition (2021) (13)
- Meeting report: Translational Research at the Aging and Cancer Interface. (2007) (11)
- Posttranscriptional changes in growth factor-inducible gene regulation caused by antiproliferative interferons. (1990) (11)
- Impact papers on aging in 2009 - eScholarship (2010) (11)
- Cellular Senescence, Aging and Cancer (2001) (11)
- Age‐associated expression of p21and p53 during human wound healing (2021) (10)
- Analysis of tumor suppressor gene-induced senescence. (2003) (10)
- 8 Cellular Senescence: A Link between Tumor Suppression and Organismal Aging? (2008) (10)
- Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types (2022) (10)
- Non‐canonical ATM/MRN activities temporally define the senescence secretory program (2020) (10)
- Interview with Judith Campisi, Ph.D. Interview by Vicki Glaser. (2011) (10)
- Skin Aging: Molecular Mechanisms and Tissue Consequences (2015) (9)
- FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16INK4a increase (2020) (9)
- Do p53 stress responses impact organismal aging? (2016) (8)
- ERBB Receptor Regulation of ESX/ELF3 Promotes Invasion in BreastEpithelial Cells (2010) (8)
- NAD+ controls neural stem cell fate in the aging brain (2014) (8)
- Tumor Necrosis Factor Alpha-Mediated Inflammation and Remodeling of the Extracellular Matrix Underlies Aortic Stiffening Induced by the Common Chemotherapeutic Agent Doxorubicin (2021) (8)
- A novel suicide gene therapy for the treatment of p16Ink4a-overexpressing tumors (2017) (8)
- Posttranslational control of cyclic AMP-dependent protein kinase by phorbol ester in normal but not in chemically transformed 3T3 cells. (1990) (8)
- Single nuclei profiling identifies cell specific markers of skeletal muscle aging, sarcopenia and senescence (2021) (8)
- Extending human healthspan and longevity: a symposium report (2021) (8)
- Loss of T-antigen sequences allows SV40-transformed human cells in crisis to acquire a senescent-like phenotype. (1997) (8)
- Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease (2012) (7)
- The Second International Conference “Genetics of Aging and Longevity” (2012) (7)
- When DNA damage goes invisible (2009) (7)
- Heregulin, a new regulator of telomere length in human cells (2015) (7)
- Fluorescence staining of living cells with fluorescamine (2005) (7)
- Heregulin, a new interactor of the telosome/shelterin complex in human telomeres (2015) (6)
- Control of cell proliferation in senescent cells. (1992) (6)
- Perspectives on cellular regulation : from bacteria to cancer : essays in honor of Arthur B. Pardee (1991) (6)
- Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and senescence (2022) (6)
- Oncogenes, protooncogenes, and tumor suppressor genes: A hitchhiker's guide to senescence? (1992) (6)
- Author Correction: Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages (2020) (6)
- Late‐Life Treatment with the Senolytic ABT‐263 Reverses Aortic Stiffening and Improves Endothelial Function with Aging (2021) (6)
- Cellular oncogenes, growth factors, and cellular growth control. (1984) (5)
- Membrane fluidity changes accompany activation of sea urchin eggs. (1982) (5)
- Age‐related telomere attrition causes aberrant gene expression in sub‐telomeric regions (2021) (5)
- Cellular mutations and drug resistance probed by herpes simplex virus (1981) (5)
- An artifact in measurement of S phase initiation and its implication for the kinetics of S phase-specific enzyme activities. (1982) (5)
- Growth Factors, Proto-Oncogenes and the Control of Cell Proliferation: Lessons from the Fibroblast (1989) (5)
- Aryl hydrocarbon receptor blocks aging-induced senescence in the liver and fibroblast cells (2021) (5)
- Procyanidin C1 is a natural agent with senolytic activity against aging and age-related diseases (2021) (5)
- Targeting epiregulin in the treatment-damaged tumor microenvironment restrains therapeutic resistance (2022) (4)
- Impact of aging on the pathophysiology of dry eye disease: A systematic review and meta-analysis. (2022) (4)
- Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation–induced impairment of neurovascular coupling responses protecting cognitive function in mice (2020) (4)
- Title: Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ macrophages (2019) (4)
- Cellular senescence mediates doxorubicin‐induced arterial dysfunction via activation of mitochondrial oxidative stress and the mammalian target of rapamycin (2021) (4)
- Tumor Suppressor and Aging Biomarker p16 INK4a Induces Cellular Senescence without the Associated Inflammatory (2011) (4)
- Matters of life and breath: A role for hypoxia in determining cell state (2012) (4)
- Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype (2018) (3)
- No restriction points in life and science. (2002) (3)
- Accelerated aging of the brain transcriptome by the common chemotherapeutic doxorubicin (2021) (3)
- Stress and Aging (2014) (3)
- The progeria research foundation 10th international scientific workshop; researching possibilities, ExTENding lives – webinar version scientific summary (2021) (3)
- CELLULAR SENESCENCE AND BRAIN AGING (2014) (3)
- Comprehensive Profiling of Plasma Exosomes Using Data-Independent Acquisitions – New Tools for Aging Cohort Studies (2021) (3)
- Parsing p53 Transactivation. (2011) (3)
- CELLULAR SENESCENCE, AGING, AND CANCER (2018) (3)
- The study of DNA-repair defects using [125I]iododeoxycytidine incorporation as an assay for the growth of herpes simplex virus. (1983) (3)
- Deregulation of the c-myc and N-myc genes in transformed cells. (1988) (3)
- Ku 80 Deletion Suppresses Spontaneous Tumors and Induces a p 53-Mediated DNA Damage Response (2008) (3)
- Prostaglandin Biosynthesis Reinforces Cellular Senescence Through a RAS/p53 Feedback Loop and Allows Detection of Senolysis (2020) (2)
- Activation of proto-oncogene expression by growth regulatory signals. (1986) (2)
- Acute myeloid leukemia induces pro-tumoral p16INK4a driven senescence in the bone marrow microenvironment (2018) (2)
- 21: Cancer and ageing: Rival demons? (2014) (2)
- Cellular Senescence and the Associated Secretome Contribute to Age‐Related Vascular Dysfunction (2022) (2)
- SENESCENCE RESPONSE TO OXIDATIVE & GENOTOXIC STRESS: A LINK BETWEEN AGING AND DISEASE (2012) (2)
- NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health. (2022) (2)
- Fisetin Supplementation Improves Age‐Related Vascular Endothelial Function by Suppressing Cellular Senescence and Mitochondrial Oxidative Stress (2022) (2)
- Leading Edge Commentary Geroscience : Linking Aging to Chronic Disease (2014) (2)
- Oxidative Damage, Somatic Mutations and Cellular Aging (2003) (2)
- Montagna Symposium 2014—Skin Aging: Molecular Mechanisms and Tissue Consequences (2015) (2)
- Hereditary orotic aciduria, Lesch‐Nyhan syndrome, and xeroderma pigmentosum probed by herpes simplex virus: 125I‐Iododeoxycytidine incorporation as an assay for viral growth (1983) (2)
- Recent advances in cellular senescence, cancer and aging (2001) (2)
- Cellular Senescence and Its Effects on Carcinogenesis (2008) (2)
- Cellular Senescence and Mammalian Healthspan (2020) (1)
- Protumorigenic Effects of the Senescence-Associated Secretory Phenotype (2008) (1)
- Cell Senescence and Aging (1998) (1)
- The inherent challenges of classifying senescence—Response (2020) (1)
- Molecular Gerontology. (Book Reviews: Molecular Biology of Aging.) (1991) (1)
- A conversation with Judith Campisi: Leader in the field of aging research (2021) (1)
- Apigenin restores endothelial function by ameliorating oxidative stress, prevents foam cell formation, reverses aortic stiffening, and mitigates vascular inflammation with aging (2021) (1)
- Abstract 4850: Sensitization to chemotherapy through interference with FOXO4 - a pivotal node between senescence and apoptosis (2012) (1)
- Age-related brain atrophy is not a homogenous process: Different functional brain networks associate differentially with aging and blood factors (2022) (1)
- Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling (2023) (1)
- Abstract C35: A pivotal role for FOXO4 in the regulation of cellular senescence and apoptosis (2011) (1)
- Cellular Senescence, Cell Death and Transgenic Mouse Models of Aging (2007) (1)
- Aging, Chromatin, and Food Restriction (2001) (1)
- Senescent cells develop PDK4-dependent hypercatabolism and form an acidic microenvironment to drive cancer resistance (2022) (1)
- Cellular Aging / Replicative Senescence (1999) (1)
- αB Crystallin Chaperone Peptide (mini Cry) Inhibits Senescence in RPE cells by Modulating Mitochondrial Biogenesis and Fission Proteins (2019) (1)
- Does senescence play a role in age-related macular degeneration? (2022) (1)
- Engineering Antibodies Targeting p16 MHC-Peptide Complexes. (2022) (1)
- Abstract 466: Cellular senescence drives skin carcinogenesis (2018) (1)
- The regulatory landscapes of human ovarian ageing (2022) (1)
- Physiological changes, fibroblast cells (2001) (1)
- 98: Term fetal membranes and senescence associated secretory phenotype (SASP)-like gene expression: a signal for parturition? (2015) (1)
- Long-Term Clearance of Senescent Cells Prevents the Hematopoietic Stem Cell Aging in Naturally Aged Mice (2019) (1)
- Abstract 4603: Targeted treatment of metastatic melanoma through interference with Pin1-FOXM1 signaling (2014) (1)
- TUMOR SUPPRESSION, AGING, AND CELLULAR SENESCENCE (2005) (1)
- Abstracts of papers presented at the 1998 Meeting on Genetics of Aging, April 2 - April 5, 1998 (1998) (0)
- Author Correction: MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation (2021) (0)
- Estela Medrano: a life of gentle passion (2011) (0)
- Issue Information (2020) (0)
- THE ROLE OF CD30 IN ALLOIMMUNE RESPONSES (2004) (0)
- University of Groningen Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson ' s Disease (2018) (0)
- Author Correction: Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages (2020) (0)
- OP-JNCI210063 1285..1298 (2021) (0)
- A direct comparison of interphase FISH versus low-coverage single cell sequencing to detect aneuploidy reveals respective strengths and weaknesses (2019) (0)
- Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing (2012) (0)
- Lawrence Berkeley National Laboratory Recent Work Title (2012) (0)
- Abstract 4507: Small molecule inhibitor of MDM2 induces p53-dependent HMGB1 secretion followed by apoptosis in cancer cells and incomplete senescence in normal fibroblasts (2011) (0)
- Abstract 2931: Synergy between secreted factors promotes a hyper-secretory phenotype which may fuel ovarian cancer progression. (2013) (0)
- Withdrawal: Selective cleavage of BLM, the Bloom syndrome protein, during apoptotic cell death. (2020) (0)
- 95th International Titisee Conference (2007) (0)
- Nucleic Acid Construct with a p16 Promoter that Causes a Prodrug Converting Enzyme to be Expressed Specifically in Senescent Cells (2018) (0)
- Cellular senescence induced by paraquat drives neuropathology associated with Parkinson's disease (2016) (0)
- Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration after peripheral nerve injury (2023) (0)
- SKI Activates Wnt/ (cid:1) -Catenin Signaling in Human Melanoma 1 (2003) (0)
- Aging cellular microenvironments (2001) (0)
- Telomeres, Apoptosis, and Senescence (2002) (0)
- Cell Senescence: Aging and Cancer (2008) (0)
- Abstract 1271: MDM2 small molecule inhibitors synergize with chemotherapeutics to attenuate senescence-driven inflammatory secretion (2015) (0)
- Use of sulfonamide inhibitors of Bcl-2 to treat senescence-associated lung conditions such as pulmonary fibrosis and chronic obstructive pulmonary disease (2017) (0)
- Cellular Senescene and Breast Cancer (2006) (0)
- New books (2004) (0)
- GENOMIC INSTABILITY CAUSED BY CHROMIUM AND VANADIUM IONS IN VITRO (2006) (0)
- Aging and the senescent cell (2012) (0)
- SILAC Analysis Reveals a Role for the Senescence-Associated Secretory Phenotype in Hemostasis (2018) (0)
- MOLECULAR GENETICS OF AGING (2010) (0)
- Enhanced synthesis and stabilization of a 68k protein in benzo(a)-pyrene transformed balb/c3t3 cells: a candidate for restriction point control of cell growth. Abstr. (1983) (0)
- The NuA4 acetyltransferase and non-canonical chromatin-associated MRN/ATM activity temporally define senescence-associated secretory programs (2018) (0)
- Genetics: Gene expression (2001) (0)
- Cellular Senescence Is Ind uced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson ’ s Disease Graphical (2018) (0)
- Dr. Paola Timiras (2009) (0)
- Aging : is it a disease ? (2018) (0)
- Targeting AREG derived from senescent stromal cells diminishes cancer resistance and averts PD-L1-mediated immunosuppression (2019) (0)
- Targeting Epiregulin in the Treatment-Damaged Tumor Microenvironment Diminishes Therapeutic Resistance (2021) (0)
- Senescence and Senolytics: State of the Art on Cellular Senescence, Senolytics, and Healthspan (2020) (0)
- Symposium: Mechanisms of Neurotoxicity and Implications for Neurological Disorders (2013) (0)
- Aging, Breast Cancer, and the Mouse Model (2003) (0)
- Role of Cell Senescence in Breast Cancer (1999) (0)
- Abstract IA6: DNA-damaging anticancer therapies modify the tumor microenvironment (2011) (0)
- Treatment of ophthalmic conditions by selectively removing senescent cells from the eye (2017) (0)
- of activity selectively eliminates senescent cells in part via restoration of p53 activity. (2020) (0)
- Arthur B. Pardee: No Restriction Points in Life and Science (2002) (0)
- Withdrawal: Selective cleavage of BLM, the Bloom syndrome protein, during apoptotic cell death. (2020) (0)
- Contents: Eur. J. Immunol. 10'16. (2016) (0)
- ANTIRETROVIRAL THERAPY DRIVES MITOCHONDRIAL DYSFUNCTION-ASSOCIATED SENESCENCE, PROMOTING LIPOATROPHY (2017) (0)
- SASP PROTEIN ASSOCIATIONS WITH HUMAN AGING HIGHLIGHTS THE ROLE OF GDF15, CST3, AND IGFBP2 (2022) (0)
- The Bloom syndrome protein is expressed in late S/G2, localizes toPML/RAD51 foci, and responds to DNA damage. (2000) (0)
- Genetics: Tumor suppression (2001) (0)
- Reply: Cancer turnover at old age (2003) (0)
- NOX2 Derived Superoxide Induces Pro-Tumoral p16INK4a Driven Senescence in the AML Bone Marrow Microenvironment (2018) (0)
- Lipoprotein in the Outer Membrane ofEscherichia coli1 (0)
- The Bloom Syndrome Protein BLM Is Selectively Cleaved during Apoptotic Cell Death (2001) (0)
- Analysis of somatic mutations in senescent cells using single-cell whole-genome sequencing (2022) (0)
- Issue Information (2020) (0)
- Disease drivers of aging Which mechanisms do or do not drive aging in diabetics ? (2017) (0)
- Lawrence Berkeley National Laboratory Recent Work Title Systemic clearance of p 16 INK 4 a-positive senescent cells mitigates age-associated intervertebral disc degeneration (2019) (0)
- Matters of Life and Breath (1970) (0)
- Impact papers on aging in 2009 Citation (2022) (0)
- SENESCENCE-DERIVED PROTEIN BIOMARKERS DURING AGING AND OSTEOARTHRITIS (2022) (0)
- Antiretroviral protease inhibitors induce features of cellular senescence that are reversible upon drug removal (2022) (0)
- ExTENding lives – webinar version scientific summary (2021) (0)
- Abstract IA10: The senescence response - yin and yang (2016) (0)
- Method of optimizing conditions for selectively removing a plurality of senescent cells from a tissue or a mixed cell population (2017) (0)
- Cancer Biology (2001) (0)
- Lawrence Berkeley National Laboratory Recent Work Title Unmasking Transcriptional Heterogeneity in Senescent Cells (2017) (0)
- Heregulin: A new shelterin component at human telomeres (2006) (0)
- A Single Cell Time Course of Senescence Uncovers Discrete Cell Trajectories and Transcriptional Heterogeneity (2023) (0)
- Molecular Gerontology (1996) (0)
- Repair pathway crosstalk in genome stability maintenance through BRCA1/2‐mediated homologous recombination (352.1) (2014) (0)
- Restriction point control of cell gro Evidence for increased stability in i (animal cells/transformation/protein degradation/cell cycle/growth c (2016) (0)
- The 15th Annual RAND Summer Institute Video (2009) (0)
- Cellular Senescence and Breast Cancer (2004) (0)
- Molecular basis of aging by Alvaro Macieira-Coelho, Editor, CRC Press, Boca Raton, FL, 1995, 528 pages, ISBN: 0-849-4786-6, Price: U.S. $149.95/outside U.S. $179.95 (1996) (0)
- Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells (2017) (0)
- Abstract 3819: Amphiregulin in damaged tumor microenvironment potentiates therapeutic resistance and enables PD-L1-mediated immunosuppression (2019) (0)
- A UNIQUE ADIPOCYTE PROGENITOR POPULATION PROMOTES AGE-RELATED ADIPOSITY (2021) (0)
- Arthur B. Pardee: In Memoriam (1921–2019) (2019) (0)
- A natural variation-based screen in mouse cells reveals USF2 as a regulator of the DNA damage response and cellular senescence (2023) (0)
- Single-cell profiling of skeletal muscle reveals a novel senolytic target: CRYAB (2021) (0)
- Role of telomeres and the senescence response in cancer and aging (2006) (0)
- Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition (2019) (0)
- RAND Summer Institute Lecture Series 2015 (2016) (0)
- 23 Aging and tumour suppression: the double-edged sword of cellular senescence (2010) (0)
- Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease (2011) (0)
- Abstract 2449: Superoxide regulates protumoral p16-driven senescence in the bone marrow microenvironment of acute myeloid leukemia (2018) (0)
- Chapter 16 – Cellular Senescence (2008) (0)
- Heregulin: A novel modulator of telomere length maintenance via regulation of the Telomere Repeat-binding Factor (TRF-2) (2006) (0)
- MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation (2015) (0)
- Control of cell proliferation in senescent cells. (1992) (0)
- A landscape of pinnacles: The extraordinary career of Arthur Pardee (2006) (0)
- Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity (2020) (0)
- Role of immune cells in the removal of deleterious senescent cells (2020) (0)
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