Judy Lieberman
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Judy Lieberman's Degrees
- Doctorate Medicine Harvard University
Why Is Judy Lieberman Influential?
(Suggest an Edit or Addition)According to Wikipedia, Judy Lieberman is a professor of pediatrics at Harvard Medical School and holds an endowed chair in cellular and molecular medicine at Boston Children's Hospital. Early life Judy Lieberman was born in September 1947, in Boston, Massachusetts, and grew up in New Jersey with her parents and two sisters Phyllis and Donna.
Judy Lieberman's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells (2007) (1935)
- Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores (2016) (1711)
- Interfering with disease: a progress report on siRNA-based therapeutics (2007) (1198)
- Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen (2007) (1191)
- RNA interference targeting Fas protects mice from fulminant hepatitis (2003) (1124)
- Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors (2005) (1008)
- Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAs (2011) (927)
- Cell death and immunity: The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal (2003) (773)
- siRNA-directed inhibition of HIV-1 infection (2002) (657)
- Knocking down disease: a progress report on siRNA therapeutics (2015) (625)
- Death by a thousand cuts: granzyme pathways of programmed cell death. (2008) (595)
- miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. (2009) (595)
- Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus (2007) (588)
- Tumor Suppressor NM23-H1 Is a Granzyme A-Activated DNase during CTL-Mediated Apoptosis, and the Nucleosome Assembly Protein SET Is Its Inhibitor (2003) (560)
- Gasdermin E suppresses tumor growth by activating anti-tumor immunity (2020) (559)
- Desperately seeking microRNA targets (2010) (497)
- Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes. (2001) (486)
- A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery (2006) (481)
- γ-H2AX Dephosphorylation by Protein Phosphatase 2A Facilitates DNA Double-Strand Break Repair (2005) (458)
- An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection (2006) (417)
- G3BP–Caprin1–USP10 complexes mediate stress granule condensation and associate with 40S subunits (2016) (395)
- Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis. (2005) (391)
- FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation (2020) (370)
- Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown (2015) (369)
- miR-200-containing extracellular vesicles promote breast cancer cell metastasis. (2014) (366)
- Control of HIV despite the discontinuation of antiretroviral therapy. (1999) (359)
- The silent revolution: RNA interference as basic biology, research tool, and therapeutic. (2005) (336)
- The silent treatment: siRNAs as small molecule drugs (2006) (336)
- The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1 (2010) (327)
- miR-200 Enhances Mouse Breast Cancer Cell Colonization to Form Distant Metastases (2009) (312)
- Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis. (2005) (299)
- Impaired function of circulating HIV-specific CD8(+) T cells in chronic human immunodeficiency virus infection. (2000) (299)
- miR-24–mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells (2009) (286)
- Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation. (1999) (273)
- gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. (2005) (272)
- Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1 (2007) (268)
- Perforin pores in the endosomal membrane trigger release of endocytosed granzyme B to the cytosol of target cells (2011) (265)
- Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infection. (2001) (263)
- Delivering the kiss of death: progress on understanding how perforin works. (2007) (260)
- Sustained Small Interfering RNA-Mediated HumanImmunodeficiency Virus Type 1 Inhibition in PrimaryMacrophages (2003) (259)
- Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A (2003) (257)
- Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing (2016) (253)
- Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury. (2004) (252)
- G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments (2014) (240)
- The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death. (2006) (240)
- Cryo-EM structure of the gasdermin A3 membrane pore (2018) (239)
- p16INK4a Translation Suppressed by miR-24 (2008) (238)
- Capture of MicroRNA–Bound mRNAs Identifies the Tumor Suppressor miR-34a as a Regulator of Growth Factor Signaling (2011) (229)
- Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras. (2011) (223)
- A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. (2008) (216)
- Dysregulation of microRNA biogenesis and gene silencing in cancer (2015) (213)
- The cytosolic exonuclease TREX1 inhibits the innate immune response to HIV-1 (2010) (212)
- Molecular basis for antagonism between PDGF and the TGFβ family of signalling pathways by control of miR‐24 expression (2010) (206)
- Nuclear war: the granzyme A-bomb. (2003) (203)
- Circulating CD8 T lymphocytes in human immunodeficiency virus-infected individuals have impaired function and downmodulate CD3 zeta, the signaling chain of the T-cell receptor complex. (1998) (201)
- A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus (2007) (201)
- Knocking down Disease with siRNAs (2006) (200)
- Mitochondria-dependent and -independent Regulation of Granzyme B–induced Apoptosis (1999) (200)
- Granzyme A Cleaves a Mitochondrial Complex I Protein to Initiate Caspase-Independent Cell Death (2008) (199)
- Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic. (2003) (198)
- Granzyme A Activates an Endoplasmic Reticulum-associated Caspase-independent Nuclease to Induce Single-stranded DNA Nicks* (2001) (194)
- CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection. (2001) (181)
- Channelling inflammation: gasdermins in physiology and disease (2021) (181)
- FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation (2022) (180)
- Conserved Regulation of p53 Network Dosage by MicroRNA–125b Occurs through Evolving miRNA–Target Gene Pairs (2011) (165)
- Granzyme A activates another way to die (2010) (164)
- Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis (2001) (160)
- Targeted Delivery of PLK1-siRNA by ScFv Suppresses Her2+ Breast Cancer Growth and Metastasis (2012) (160)
- miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53. (2009) (159)
- Gasdermin D pore structure reveals preferential release of mature interleukin-1 (2021) (157)
- A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells. (2013) (155)
- Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites (2016) (151)
- Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes (2014) (148)
- miR-34 and p53: New Insights into a Complex Functional Relationship (2015) (143)
- The prospect of silencing disease using RNA interference. (2005) (143)
- HMG2 Interacts with the Nucleosome Assembly Protein SET and Is a Target of the Cytotoxic T-Lymphocyte Protease Granzyme A (2002) (143)
- A modular platform for targeted RNAi therapeutics (2018) (139)
- Whither or Wither Microbicides? (2008) (139)
- Inflammasome activation in infected macrophages drives COVID-19 pathology (2022) (137)
- Direct cleavage of the human DNA fragmentation factor‐45 by granzyme B induces caspase‐activated DNase release and DNA fragmentation (2001) (134)
- Tapping the RNA world for therapeutics (2018) (134)
- A Sound Rationale Needed for Phase III HIV-1 Vaccine Trials (2004) (133)
- Running interference: prospects and obstacles to using small interfering RNAs as small molecule drugs. (2006) (133)
- Special delivery: targeted therapy with small RNAs (2011) (133)
- Inflammasome activation at the crux of severe COVID-19 (2021) (131)
- CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy (2020) (130)
- Perforin is not co-expressed with granzyme A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic HIV infection. (1999) (129)
- Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer (2017) (128)
- Promise and challenge of RNA interference-based therapy for cancer. (2011) (125)
- Human Immunodeficiency Virus-Specific Circulating CD8 T Lymphocytes Have Down-Modulated CD3ζ and CD28, Key Signaling Molecules for T-Cell Activation (2000) (124)
- Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3′ Uridylated Intermediates Degraded by DIS3L2 (2015) (117)
- Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis. (2010) (117)
- Interfering with disease: opportunities and roadblocks to harnessing RNA interference (2003) (117)
- miR-200 promotes the mesenchymal to epithelial transition by suppressing multiple members of the Zeb2 and Snail1 transcriptional repressor complexes (2016) (105)
- A transgenic mouse model to analyze CD8(+) effector T cell differentiation in vivo. (1999) (103)
- Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV. (2005) (102)
- Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them. (1997) (102)
- Gasdermin D activity in inflammation and host defense (2019) (101)
- Induction of cell-mediated immune responses to human immunodeficiency virus type 1 Gag protein by using Listeria monocytogenes as a live vaccine vector. (1995) (99)
- Bone Morphogenetic Protein 4 Promotes Vascular Smooth Muscle Contractility by Activating MicroRNA-21 (miR-21), which Down-regulates Expression of Family of Dedicator of Cytokinesis (DOCK) Proteins* (2011) (98)
- Induction of Rapid Histone Degradation by the Cytotoxic T Lymphocyte Protease Granzyme A* (2001) (98)
- Granzyme B-induced mitochondrial ROS are required for apoptosis (2014) (97)
- A Mechanistic Understanding of Pyroptosis: The Fiery Death Triggered by Invasive Infection. (2017) (95)
- The SET Complex Acts as a Barrier to Autointegration of HIV-1 (2009) (95)
- Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach (2012) (94)
- Diagnostic Potential of Imaging Flow Cytometry. (2018) (94)
- Treatment of human immunodeficiency virus infection with hydroxyurea, didanosine, and a protease inhibitor before seroconversion is associated with normalized immune parameters and limited viral reservoir. (1999) (94)
- Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene. (2009) (93)
- HIV-1 Antiviral Activity of Recombinant Natural Killer Cell Enhancing Factors, NKEF-A and NKEF-B, Members of the Peroxiredoxin Family* (2003) (93)
- The Rab2A GTPase Promotes Breast Cancer Stem Cells and Tumorigenesis via Erk Signaling Activation (2015) (85)
- Identification and Characterization of PWWP Domain Residues Critical for LEDGF/p75 Chromatin Binding and Human Immunodeficiency Virus Type 1 Infectivity (2008) (85)
- Viral-specific cytotoxic T lymphocytes lyse human immunodeficiency virus-infected primary T lymphocytes by the granule exocytosis pathway. (1999) (84)
- Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts (2020) (83)
- Small RNAs Guide Hematopoietic Cell Differentiation and Function (2010) (82)
- Mapping cross-clade HIV-1 vaccine epitopes using a bioinformatics approach. (2003) (81)
- Tumor-secreted extracellular vesicles promote the activation of cancer-associated fibroblasts via the transfer of microRNA-125b (2019) (80)
- Absence of recoverable infectious virus and unique immune responses in an asymptomatic HIV+ long-term survivor. (1994) (80)
- Cytotoxic T lymphocytes from HIV-1 seropositive individuals recognize immunodominant epitopes in Gp160 and reverse transcriptase. (1992) (80)
- Distribution of Immune Cells in the Human Cervix and Implications for HIV Transmission (2014) (77)
- Granzyme B Binds to Target Cells Mostly by Charge and Must Be Added at the Same Time as Perforin to Trigger Apoptosis 1 (2005) (77)
- Listeria-Infected Myeloid Dendritic Cells Produce IFN-β, Priming T Cell Activation 1 (2005) (73)
- Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras. (2013) (71)
- Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells (2007) (71)
- Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancer. (2014) (71)
- Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis (2022) (70)
- HIV DNA is heavily uracilated, which protects it from autointegration (2011) (70)
- Adenovirus Protein VII Functions throughout Early Phase and Interacts with Cellular Proteins SET and pp32 (2005) (68)
- Resistance of HIV-infected macrophages to CD8 T lymphocyte-mediated killing drives immune activation (2018) (67)
- Harnessing RNAi-based nanomedicines for therapeutic gene silencing in B-cell malignancies (2015) (66)
- Increased expression of the natural killer cell inhibitory receptor CD85j/ILT2 on antigen‐specific effector CD8 T cells and its impact on CD8 T‐cell function (2004) (65)
- Noncoding RNAs and Cancer (2013) (65)
- Safety of autologous, ex vivo-expanded human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte infusion in HIV-infected patients. (1997) (64)
- Gene Knockdown by EpCAM Aptamer–siRNA Chimeras Suppresses Epithelial Breast Cancers and Their Tumor-Initiating Cells (2015) (64)
- CD3ζ and CD28 down-modulation on CD8 T cells during viral infection (2000) (63)
- Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell–mediated cytotoxicity (2013) (63)
- A role for heat shock protein 27 in CTL-mediated cell death. (1998) (62)
- Determinants of specific RNA interference-mediated silencing of human beta-globin alleles differing by a single nucleotide polymorphism. (2006) (62)
- SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release (2021) (61)
- Vaccinia Virus Induces Strong Immunoregulatory Cytokine Production in Healthy Human Epidermal Keratinocytes: a Novel Strategy for Immune Evasion (2005) (57)
- Efficient and specific gene knockdown by small interfering RNAs produced in bacteria (2013) (57)
- The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1. (2009) (56)
- Granzyme A, which causes single‐stranded DNA damage, targets the double‐strand break repair protein Ku70 (2006) (56)
- Characterization of dual PTEN and p53-targeting microRNAs identifies microRNA-638/Dnm2 as a two-hit oncogenic locus. (2014) (53)
- Induction of Human Immunodeficiency Virus (HIV)-Specific CD8 T-Cell Responses by Listeria monocytogenes and a Hyperattenuated Listeria Strain Engineered To Express HIV Antigens (2000) (53)
- Cytotoxic CD8+ T cells recognize and kill Plasmodium vivax-infected reticulocytes (2018) (53)
- Sequencing of captive target transcripts identifies the network of regulated genes and functions of primate-specific miR-522. (2014) (52)
- SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism (2020) (52)
- Expansion of CD57 and CD62L-CD45RA+ CD8 T lymphocytes correlates with reduced viral plasma RNA after primary HIV infection. (1999) (51)
- Silencing Viral Infection (2006) (50)
- Resistance of HIV-infected macrophages to CD8+ T lymphocyte–mediated killing drives activation of the immune system (2018) (50)
- Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program (2017) (50)
- PNPT1 Release from Mitochondria during Apoptosis Triggers Decay of Poly(A) RNAs (2018) (49)
- Safety of Autologous, Ex Vivo-Expanded Human Immunodeficiency Virus (HIV)-Specific Cytotoxic T-Lymphocyte Infusion in HIV-Infected Patients (1997) (49)
- Knocking 'em Dead: Pore-Forming Proteins in Immune Defense. (2020) (49)
- Genetically modified anthrax lethal toxin safely delivers whole HIV protein antigens into the cytosol to induce T cell immunity. (2000) (48)
- Isolation of Cytotoxic T Cell and NK Granules and Purification of Their Effector Proteins (2010) (47)
- NFAT5 Regulates HIV-1 in Primary Monocytes via a Highly Conserved Long Terminal Repeat Site (2006) (47)
- Leukocyte Protease Binding to Nucleic Acids Promotes Nuclear Localization and Cleavage of Nucleic Acid Binding Proteins (2014) (46)
- Perforin: a key pore-forming protein for immune control of viruses and cancer. (2014) (45)
- STING inhibitors target the cyclic dinucleotide binding pocket (2021) (45)
- The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia (2021) (44)
- Avoiding the kiss of death: how HIV and other chronic viruses survive. (2002) (43)
- Anatomy of a murder: how cytotoxic T cells and NK cells are activated, develop, and eliminate their targets (2010) (42)
- Prediction of HIV peptide epitopes by a novel algorithm. (1996) (42)
- Ex Vivo Cytosolic Delivery of Functional Macromolecules to Immune Cells (2015) (42)
- Expression and purification of enzymatically active recombinant granzyme B in a baculovirus system. (1998) (41)
- The Bcl‐2 family pro‐apoptotic molecule, BNIP3 regulates activation‐induced cell death of effector cytotoxic T lymphocytes (2003) (41)
- Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges. (2011) (40)
- Engineered Listeria monocytogenes as an AIDS vaccine. (2002) (40)
- Live or let die: posttranscriptional gene regulation in cell stress and cell death (2013) (39)
- Live attenuated Listeria monocytogenes expressing HIV Gag: immunogenicity in rhesus monkeys. (2007) (39)
- Three regions of HIV-1 gp160 contain clusters of immunodominant CTL epitopes. (1996) (39)
- The gp49B1 Inhibitory Receptor Regulates the IFN-γ Responses of T Cells and NK Cells (2003) (39)
- NLRP3 inflammasome activation triggers gasdermin D–independent inflammation (2021) (38)
- Capture and Identification of miRNA Targets by Biotin Pulldown and RNA-seq. (2016) (38)
- RNA interference and cancer: endogenous pathways and therapeutic approaches. (2008) (38)
- Lighting a Fire: Can We Harness Pyroptosis to Ignite Antitumor Immunity? (2021) (37)
- γδ T cells suppress Plasmodium falciparum blood stage infection by direct killing and phagocytosis (2020) (37)
- Ex vivo expansion of HIV type 1-specific cytolytic T cells from HIV type 1-seropositive subjects. (1995) (36)
- SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release (2021) (35)
- Recognition of a small number of diverse epitopes dominates the cytotoxic T lymphocytes response to HIV type 1 in an infected individual. (1997) (35)
- Numbers matter: quantitative and dynamic analysis of the formation of an immunological synapse using imaging flow cytometry. (2009) (34)
- CD3zeta and CD28 down-modulation on CD8 T cells during viral infection. (2000) (34)
- Micromanipulating cancer: microRNA-based therapeutics? (2009) (34)
- Granulysin: killer lymphocyte safeguard against microbes. (2019) (34)
- A fragment of anthrax lethal factor delivers proteins to the cytosol without requiring protective antigen (2003) (34)
- Alterations in RNA processing during immune-mediated programmed cell death (2012) (34)
- EBV-specific cytotoxic T lymphocytes protect against human EBV-associated lymphoma in scid mice. (1996) (34)
- p16 Translation Suppressed by miR-24 (2008) (33)
- Immune restoration by combination of a cytostatic drug (hydroxyurea) and anti-HIV drugs (didanosine and indinavir). (1999) (33)
- Basal-A Triple-Negative Breast Cancer Cells Selectively Rely on RNA Splicing for Survival (2017) (33)
- The functional CD8 T cell response to HIV becomes type-specific in progressive disease. (2002) (32)
- TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice. (2016) (31)
- Gaining a foothold: how HIV avoids innate immune recognition. (2011) (29)
- A vaccinia-gp160-based vaccine but not a gp160 protein vaccine elicits anti-gp160 cytotoxic T lymphocytes in some HIV-1 seronegative vaccinees. (1995) (29)
- Tracking the killers: how should we measure CD8 T cells in HIV infection? (2004) (29)
- Identification of pyroptosis inhibitors that target a reactive cysteine in gasdermin D (2018) (28)
- Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation. (2017) (28)
- Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown (2021) (28)
- Hydroxyurea and didanosine long-term treatment prevents HIV breakthrough and normalizes immune parameters. (1999) (27)
- Targeting stem-loop 1 of the SARS-CoV-2 5′ UTR to suppress viral translation and Nsp1 evasion (2021) (27)
- An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates* (2015) (24)
- Myeloid Cells in Intact Human Cervical Explants Capture HIV and Can Transmit It to CD4 T Cells (2018) (24)
- CD43 diminishes susceptibility to T lymphocyte-mediated cytolysis. (1995) (23)
- Micromanaging hepatitis C virus. (2013) (23)
- An Epigenetic Clock Measures Accelerated Aging in Treated HIV Infection. (2016) (23)
- Cleavage of Transaldolase by Granzyme B Causes the Loss of Enzymatic Activity with Retention of Antigenicity for Multiple Sclerosis Patients (2010) (22)
- Disulfiram use is associated with lower risk of COVID-19: A retrospective cohort study (2021) (22)
- Corrigendum: A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery (2006) (21)
- Defying death--HIV mutation to evade cytotoxic T lymphocytes. (2002) (20)
- Effective lysis of HIV-1-infected primary CD4+ T cells by a cytotoxic T-lymphocyte clone directed against a novel A2-restricted reverse-transcriptase epitope. (1998) (19)
- Production of highly potent recombinant siRNAs in Escherichia coli (2013) (19)
- EMD-7449 Title : Cryo-EM structure of the Gasdermin A 3 membrane pore (2018) (19)
- The gp49B1 inhibitory receptor regulates the IFN-gamma responses of T cells and NK cells. (2003) (18)
- TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization (2021) (18)
- Proliferation responses to HIVp24 during antiretroviral therapy do not reflect improved immune phenotype or function (2004) (18)
- Micromanagers of immune cell fate and function. (2009) (17)
- Chemoattractant-mediated leukocyte trafficking enables HIV dissemination from the genital mucosa. (2017) (16)
- miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential (2018) (16)
- HIV virions and HIV infection in vitro are unaffected by human granzymes A and B. (2000) (15)
- Gasdermin E suppresses tumour growth by activating anti-tumour immunity (2020) (14)
- Effect of interleukin 12 on in vitro HIV type 1 replication depends on clinical stage. (1996) (14)
- A simple method to selectively expand HIV-1 specific cytotoxic T lymphocytes in vitro. (1995) (14)
- Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV (2011) (12)
- Mechanisms of granule-mediated cytotoxicity (2003) (12)
- Decidual NK cells kill Zika virus–infected trophoblasts (2021) (12)
- Using T cells to treat B-cell cancers. (1994) (11)
- SPARCLE, a p53-induced lncRNA, controls apoptosis after genotoxic stress by promoting PARP-1 cleavage. (2020) (11)
- A High Yield and Cost-efficient Expression System of Human Granzymes in Mammalian Cells. (2015) (11)
- Erratum: Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes (Cell (2014) 153 (1309-1323) DOI: 10.1016/j.cell.2015.05.021) (2015) (10)
- Serum enhances the ex vivo generation of HIV‐specific cytotoxic T cells (2000) (10)
- SAMHD1 does it again, now in resting T cells (2012) (9)
- How ICE lights the pyroptosis fire (2017) (9)
- g-H 2 AX Dephosphorylation by Protein Phosphatase 2 A Facilitates DNA Double-Strand Break Repair (9)
- THE SILENT REVOLUTION: RNA Interference as (2005) (9)
- Harnessing RNA interference for therapy: the silent treatment. (2015) (9)
- miR-34 a contributes to megakaryocytic differentiation of K 562 cells independently of p 53 (2009) (9)
- Cross-Clade CD8 T-Cell Responses to HIVIIIB and Chinese B′ and C/B′ Viruses in North American and Chinese HIV-Seropositive Donors (2004) (9)
- Manipulating the in vivo immune response by targeted gene knockdown. (2015) (8)
- RIG-ing an antitumor response (2008) (8)
- Contributions of IFN-γ and granulysin to the clearance of Plasmodium yoelii blood stage (2020) (8)
- Viral replication in human macrophages enhances an inflammatory cascade and interferon driven chronic COVID-19 in humanized mice. (2021) (7)
- Abstract LB-299: Gene knockdown by EpCAM aptamer-siRNA chimeras suppresses epithelial breast cancers and their tumor-initiating cells (2015) (7)
- Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3 0 Uridylated Intermediates (2015) (7)
- Cytotoxic Lymphocytes (2016) (7)
- Response: Granzyme A: cell death–inducing protease, proinflammatory agent, or both? (2009) (7)
- Tombusvirus p19 Captures RNase III-Cleaved Double-Stranded RNAs Formed by Overlapping Sense and Antisense Transcripts in Escherichia coli (2020) (6)
- siRNA-directed inhibition of HIV-1 infection (2003) (6)
- Micromanaging cancer. (2009) (6)
- Cell lineage as a predictor of immune response in neuroblastoma (2021) (6)
- Lighting a fire on the reef (2020) (5)
- Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes (2015) (5)
- lymphocytes correlates with reduced viral plasma RNA after primary HIV infection (1999) (5)
- Harvard's women four years later (2009) (5)
- FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation (2022) (5)
- mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis (2022) (4)
- Erratum: siRNA-directed inhibition of HIV-1 infection (Nature Medicine (2002) 8 (681-686)) (2003) (4)
- Clonal expansion of antigen-specific CD8+ cytotoxic T lymphocytes is regulated by late exposure to serum to prevent apoptosis. (1999) (4)
- Bone Morphogenetic Protein 4 Promotes Vascular Smooth Muscle Contractility by Activating MicroRNA-21 (miR-21), which Down-regulates Expression of Family of Dedicator of (2012) (4)
- Infection Through a Functional Genomic Screen Identification of Host Proteins Required for HIV (2008) (4)
- Activation of GSDME compensates for GSDMD deficiency in a mouse model of NLRP3 inflammasomopathy (2021) (3)
- Unveiling the RNA World (2018) (3)
- Enhanced susceptibility to human immunodeficiency virus infection in CD4+ T lymphocytes genetically deficient in CD43. (1995) (3)
- Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes (2022) (3)
- An RNA-binding protein , Lin 28 , recognizes and remodels G-quartets in the miRNAs and mRNAs it regulates (2015) (3)
- Mechanisms driving altered v delta 2+gamma delta t cell function during recurrent malaria infection (2019) (2)
- Human Immunodeficiency Virus-Specific Circulating CD8 T Lymphocytes Have Down-Modulated CD3 z and CD28, Key Signaling Molecules for T-Cell Activation (2000) (2)
- 144 The Cytosolic Exonuclease TREX1 Digests HIV Reverse Transcripts to Avoid Triggering an Antiviral Interferon Response in T Cells and Macrophages (2012) (2)
- ROS-dependent palmitoylation is an obligate licensing modification for GSDMD pore formation (2023) (2)
- Abstract B057: Enhancing immunotherapy for triple-negative and HER2+ breast cancer using EpCAM aptamer-siRNA mediated gene knockdown (2019) (2)
- The Cytolytic T Cell Response to HIV-1 (1996) (1)
- P19-22. CD4-targeted delivery of HIV and CCR5 siRNAs by aptamer-siRNA chimeras suppresses HIV infection in primary cells and in human cervical explants (2009) (1)
- The NK receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells (2021) (1)
- Palmitoylation of gasdermin D directs its membrane translocation and pore formation in pyroptosis (2023) (1)
- Title Blocking the Recruitment of Naive CD 4 + T Cells ReversesImmunosuppression in Breast Cancer (2017) (1)
- Author Correction: Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis (2022) (1)
- Binding Of Immune Serine Proteases To Nucleic Acids Enhances Their Nuclear Localization and Promotes Their Cleavage Of Nucleic Acid-Binding Protein Substrates (2013) (1)
- Harnessing RNA Interference for Therapy (2015) (1)
- The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells (2023) (1)
- and cytomegalovirus lack molecules for homing to lymphoid sites of infection CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, (2011) (1)
- The international social entrepreneur (2014) (1)
- Correction: G3BP–Caprin1–USP10 complexes mediate stress granule condensation and associate with 40S subunits (2019) (1)
- Inflammasome activation in infected macrophages drives COVID-19 pathology (2022) (1)
- Differentiation and Function Small RNAs Guide Hematopoietic Cell (2010) (1)
- γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis (2021) (1)
- Abstract SY09-04: Cancer crosstalk: miR-200-containing extracellular vesicles promote breast cancer cell metastasis (2015) (1)
- Author Correction: Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis (2022) (0)
- Abstract A022: Gasdermin E suppresses tumor growth by activating antitumor immunity (2019) (0)
- DRUGS THAT INHIBIT HERPESVIRUS DNA SYNTHESIS BLOCK IN VITRO ACTIVATION OF THE KAPOSI'S SARCOMA-ASSOCIATED HERPES VIRUS(KSHV) IN PERIPHERAL BLOOD MONONUCLEAR CELLS.: 40 (1997) (0)
- Selective Inhibition of Polymorphonuclear Leukocyte Oxidative Burst and CD11b/CD16 Expression by Prostaglandin E2 (1993) (0)
- Abstract CN01-02: Targeting basal-like TNBCs and epithelial tumor-initiating cells with aptamer-siRNA chimeras. (2013) (0)
- Patients Retention of Antigenicity for Multiple Causes the Loss of Enzymatic Activity with Cleavage of Transaldolase by Granzyme B (2010) (0)
- Differential susceptibility to granzymes drives delayed apoptosis of HIV-infected macrophages and promotes CTL pro-inflammatory cytokine release (2017) (0)
- Unbiased Analyses of Signaling Through Leukemia Associated MicroRNA (2011) (0)
- Micromanipulating Hematological Malignancies and Other Cancers (2010) (0)
- Chinese scientists and US leadership in the life sciences (2019) (0)
- The SET oncoprotein promotes estrogen-induced transcription by facilitating establishment of active chromatin. (2023) (0)
- Mechanisms of granule-mediated cytotoxicity Editorial overview (2003) (0)
- Inhibition in Primary Macrophages Human Immunodeficiency Virus Type 1 Sustained Small Interfering RNA-Mediated (2003) (0)
- Developing a Topical HIV Microbicide: CD4-targeting Aptamers Inhibit HIV Infection in Primary Cells in vitro and in Polarized Human Cervical Explants (2010) (0)
- Functional Screening Of Oncomir-196b-RISC Captured Targets Reveal Mir-Inhibition Of Tumor Suppressor Activity In MLL-AF9 Mediated Leukemogenesis (2013) (0)
- Pore Formation Mechanism of Human Gasdermin D (2020) (0)
- Naïve CD4+ T Cells, Recruited by CCL18 Secreted by Tumor-Associated Macrophages, Differentiate Within Breast Tumors into Tumor-Infiltrating Regulatory T Cells (2017) (0)
- Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration (2022) (0)
- clades and primary isolates of HIV Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple (2013) (0)
- of Nucleic Acid Binding Proteins Promotes Nuclear Localization and Cleavage Leukocyte Protease Binding to Nucleic Acids (2014) (0)
- multiple clades and primary isolates of HIV Lentiviral delivery of short hairpin RNAs protects CD4 T cells from (2010) (0)
- Focal Adhesion Kinase (FAK) Is Required for CXCL12-Induced Dhemotaxis and Adhesion to VCAM-1 in B Lymphocytes and Hematopoietic Stem/Progenitor Cells. (2006) (0)
- Cytotoxic CD8+ T cells recognize and kill Plasmodium vivax–infected reticulocytes (2018) (0)
- Decision letter: Cytoplasmic mRNA decay represses RNA polymerase II transcription during early apoptosis (2020) (0)
- Tombusvirus p19 captures RNase III-cleaved double-stranded RNAs formed by overlapping sense and antisense transcripts in E. coli (2019) (0)
- independently of p53 miR-34a contributes to megakaryocytic differentiation of K562 cells (2010) (0)
- Abstract B58: Gasdermin E suppresses tumor growth by activating antitumor immunity (2020) (0)
- Abstract SY43-03: Screening for triple negative breast cancer vulnerabilities (2014) (0)
- Channelling inflammation: gasdermins in physiology and disease (2021) (0)
- TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization (2021) (0)
- Abstract 2034: Activation of cancer-associated fibroblasts via the transfer of miR-125b containing extracellular vesicles from tumor cells (2019) (0)
- FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation (2020) (0)
- Sounding the Alarm and Putting Out the Fire: New Mechanistic Insights into Inflammatory Cell Death (2019) (0)
- T.19.5. Synthesis of a Bifunctional Chimera: Discriminate Delivery of siRNA to CD4+Cells by Fusion to RNA-based Aptamers (2009) (0)
- Abstract A08: Divergent tumor cell states in neuroblastoma possess distinct immunogenic phenotypes (2022) (0)
- Cryo-EM structure of the gasdermin A3 membrane pore (2018) (0)
- Responses of T Cells and NK Cells γ IFN- The gp49B1 Inhibitory Receptor Regulates the (2010) (0)
- Accumulation of neutrophil-phagocytic antibody features tracks with naturally acquired immunity against malaria in children (2023) (0)
- progressive immunodeficiency in HIV-1 infection Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent (2010) (0)
- Alternative splicing of GSDMB modulates killer lymphocyte–triggered pyroptosis (2023) (0)
- Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer (2017) (0)
- A microRNA pulldown approach uncovers regulation of p53 activity and growth factor signaling by miR‐34a (2012) (0)
- Methode d'interference arn et utilisations (2005) (0)
- RNA Interference in Mouse Models (2004) (0)
- as Perforin to Trigger Apoptosis Charge and Must Be Added at the Same Time Granzyme B Binds to Target Cells Mostly by (2010) (0)
- Harnessing RNA interference to prevent or treat HSV-2 and HIV (2006) (0)
- The Tumor Suppressor NM23-H1 Is the Granzyme A-Activated DNase and the Nucleosome Assembly Protein SET Is Its Inhibitor (2002) (0)
- PD-1 traffics to the immunological synapse along the plasma membrane to inhibit CTL cytotoxicity and cytokine secretion (44.25) (2009) (0)
- Abstract A132: Identification of pyroptosis inhibitors that target a reactive cysteine in gasdermin D (2019) (0)
- The Kiss of Death: A New Model for How Perforin Delivers Granzymes to Target Cells (2005) (0)
- CORRECTION (1990) (0)
- Numbers matter: quantitative and dynamic analysis of the formation of a mature immunological synapse using imaging flow cytometry (42.15) (2009) (0)
- Therapeutique du vih (2003) (0)
- Author's address (2010) (0)
- Cell Gamma Receptor (2008) (0)
- Kidney size in acute leukemia. (1958) (0)
- T cell gamma receptor (1987) (0)
- Tapping the RNA world for therapeutics (2018) (0)
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