Jukka Mönkkönen
#41,461
Most Influential Person Now
Finnish pharmacist , professor of biopharmacy and rector of the University of Eastern Finland
Jukka Mönkkönen's AcademicInfluence.com Rankings
Download Badge
Chemistry
Jukka Mönkkönen's Degrees
- PhD Pharmacy University of Helsinki
Why Is Jukka Mönkkönen Influential?
(Suggest an Edit or Addition)According to Wikipedia, Jukka Mönkkönen is a Finnish Professor of Biopharmacy and Rector of the University of Eastern Finland. Jukka Mönkkönen served as the Academic Rector of the University of Eastern Finland in 2012–2014, he was then elected Rector for a five-year term in 2015 and re-elected for another five-year period starting on 1 January 2020. The decision was taken unanimously by the board of the University of Eastern Finland on 21 May 2019.
Jukka Mönkkönen's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Biochemical and molecular mechanisms of action of bisphosphonates. (2011) (441)
- Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset. (2012) (431)
- Clodronate and Liposome‐Encapsulated Clodronate Are Metabolized to a Toxic ATP Analog, Adenosine 5′‐(β,γ‐Dichloromethylene) Triphosphate, by Mammalian Cells In Vitro (1997) (393)
- Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite. (2002) (304)
- A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen‐containing bisphosphonates (2006) (275)
- Human breast cancer cells educate macrophages toward the M2 activation status (2015) (267)
- The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis. (2001) (256)
- Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs. (1999) (254)
- Peripheral blood monocytes are responsible for γδ T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP (2009) (254)
- Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories. (2008) (248)
- Characteristics of clodronate-induced apoptosis in osteoclasts and macrophages. (1996) (244)
- Interaction of liposomes with human skin in vitro--the influence of lipid composition and structure. (1996) (242)
- Transferrin mediated solid lipid nanoparticles containing curcumin: enhanced in vitro anticancer activity by induction of apoptosis. (2010) (233)
- Macrophage Depletion by Clodronate-Containing Liposomes Reduces Neointimal Formation After Balloon Injury in Rats and Rabbits (2002) (225)
- Molecular mechanisms of action of bisphosphonates. (1999) (171)
- Liposome-skin interactions and their effects on the skin permeation of drugs. (1999) (165)
- Effect of Liposomal and Free Bisphosphonates on the IL-1β, IL-6 and TNFα Secretion from RAW 264 Cells in Vitro (1995) (162)
- Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5'-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro. (1997) (161)
- Butyrophilin 3A1 Plays an Essential Role in Prenyl Pyrophosphate Stimulation of Human Vγ2Vδ2 T Cells (2013) (156)
- Phospholipids affect stratum corneum lipid bilayer fluidity and drug partitioning into the bilayers. (1999) (147)
- High phosphoantigen levels in bisphosphonate-treated human breast tumors promote Vgamma9Vdelta2 T-cell chemotaxis and cytotoxicity in vivo. (2011) (137)
- Rapid screening method for osteoclast differentiation in vitro that measures tartrate-resistant acid phosphatase 5b activity secreted into the culture medium. (2000) (136)
- Tissue distribution, metabolism, and excretion of 14C-TCDD in a TCDD-susceptible and a TCDD-resistant rat strain. (1990) (124)
- Measurement of hydration in the stratum corneum with the MoistureMeter and comparison with the Corneometer (2004) (117)
- Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity. (2001) (115)
- Drug adsorption to plastic containers and retention of drugs in cultured cells under in vitro conditions. (2006) (115)
- Contrasting effects of alendronate and clodronate on RAW 264 macrophages: the role of a bisphosphonate metabolite. (1999) (109)
- Effect of liposomal and free bisphosphonates on the IL-1 beta, IL-6 and TNF alpha secretion from RAW 264 cells in vitro. (1995) (104)
- ApoE3 mediated poly(butyl) cyanoacrylate nanoparticles containing curcumin: study of enhanced activity of curcumin against beta amyloid induced cytotoxicity using in vitro cell culture model. (2010) (100)
- Identification of adenine nucleotide-containing metabolites of bisphosphonate drugs using ion-pair liquid chromatography-electrospray mass spectrometry. (1997) (97)
- Analysis of unstirred water layer in in vitro permeability experiments. (2009) (96)
- A peptide prodrug approach for improving bisphosphonate oral absorption. (2000) (95)
- Opsonization, Biodistribution, Cellular Uptake and Apoptosis Study of PEGylated PBCA Nanoparticle as Potential Drug Delivery Carrier (2011) (95)
- Oligonucleotide-cationic liposome interactions. A physicochemical study. (1994) (91)
- Growth inhibition of macrophage-like and other cell types by liposome-encapsulated, calcium-bound, and free bisphosphonates in vitro. (1994) (90)
- Zoledronic acid potentiates mTOR inhibition and abolishes the resistance of osteosarcoma cells to RAD001 (Everolimus): pivotal role of the prenylation process. (2010) (89)
- Comparison of the distribution of three bisphosphonates in mice. (1990) (86)
- Effects of tiludronate and ibandronate on the secretion of proinflammatory cytokines and nitric oxide from macrophages in vitro. (1998) (83)
- Zoledronic acid induces formation of a pro‐apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF‐7 cells in vitro (2009) (79)
- Indirect Stimulation of Human Vγ2Vδ2 T Cells through Alterations in Isoprenoid Metabolism (2011) (78)
- Bisphosphonate-induced ATP analog formation and its effect on inhibition of cancer cell growth (2008) (75)
- Zoledronic acid-induced IPP/ApppI production in vivo. (2007) (72)
- In vitro comparison of clodronate, pamidronate and zoledronic acid effects on rat osteoclasts and human stem cell-derived osteoblasts. (2005) (72)
- Systemic Depletion of Macrophages by Liposomal Bisphosphonates Reduces Neointimal Formation Following Balloon-Injury in the Rat Carotid Artery (2003) (71)
- Effects of low-dose, noncytotoxic, intraarticular liposomal clodronate on development of erosions and proteoglycan loss in established antigen-induced arthritis in rabbits. (2001) (70)
- A lipid carrier with a membrane active component and a small complex size are required for efficient cellular delivery of anti-sense phosphorothioate oligonucleotides. (2000) (69)
- Aminobisphosphonate-pretreated dendritic cells trigger successful Vγ9Vδ2 T cell amplification for immunotherapy in advanced cancer patients (2010) (63)
- Streptomyces spores from mouldy houses induce nitric oxide, TNFα and IL-6 secretion from RAW264.7 macrophage cell line without causing subsequent cell death. (1997) (62)
- Calcitonin promotes osteoclast survival in vitro (1996) (62)
- Activation of γδ T cells by bisphosphonates. (2010) (61)
- Enhancement of percutaneous absorption of naproxen by phospholipids (1998) (58)
- Comparison of in vitro cell models in predicting in vivo brain entry of drugs. (2010) (58)
- siRNA Transfection with Calcium Phosphate Nanoparticles Stabilized with PEGylated Chelators (2013) (57)
- Accumulation of bisphosphonates in the aorta and some other tissues of healthy and atherosclerotic rabbits. (1996) (57)
- The level of ATP analog and isopentenyl pyrophosphate correlates with zoledronic acid-induced apoptosis in cancer cells in vitro. (2009) (54)
- Molecular mechanisms of actions of bisphosphonates and new insights into their effects outside the skeleton. (2020) (54)
- In Vivo Phosphoantigen Levels in Bisphosphonate-Treated Human Breast Tumors Trigger Vγ9Vδ2 T-cell Antitumor Cytotoxicity through ICAM-1 Engagement (2012) (52)
- Regulation of MMP-9 (gelatinase B) in activated human monocyte/macrophages by two different types of bisphosphonates. (2003) (51)
- Induced production of nitric oxide, tumor necrosis factor, and interleukin-6 in RAW 264.7 macrophages by streptomycetes from indoor air of moldy houses. (1997) (50)
- ApoE3 mediated polymeric nanoparticles containing curcumin: apoptosis induced in vitro anticancer activity against neuroblastoma cells. (2012) (49)
- In vitro-in vivo correlation in P-glycoprotein mediated transport in intestinal absorption. (2009) (48)
- Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells. (2010) (47)
- Measurement of oedema in irritant‐exposed skin by a dielectric technique (2006) (46)
- Inhibition of Growth of Dictyostelium discoideum Amoebae by Bisphosphonate Drugs Is Dependent on Cellular Uptake (1997) (46)
- Quantitative determination of cholesterol, sitosterol, and sitostanol in cultured Caco-2 cells by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. (2005) (46)
- Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry. (2009) (46)
- A one year follow-up study of the distribution of 14C-clodronate in mice and rats. (1988) (46)
- Conditioned medium of estrogen-treated osteoblasts inhibits osteoclast maturation and function in vitro. (1999) (44)
- Clodronate (dichloromethylene bisphosphonate) inhibits LPS-stimulated IL-6 and TNF production by RAW 264 cells. (1994) (43)
- The uptake of clodronate (dichloromethylene bisphosphonate) by macrophages in vivo and in vitro. (1989) (42)
- The Asymmetry of the Unstirred Water Layer in Permeability Experiments (2008) (42)
- Absorption properties and P-glycoprotein activity of modified Caco-2 cell lines. (2005) (41)
- Different effects of three bisphosphonates on nitric oxide production by RAW 264 macrophage-like cells in vitro. (1996) (41)
- Effects of various absorption enhancers on transport of clodronate through Caco-2 cells. (2003) (41)
- Physicochemical and morphological properties of complexes made of cationic liposomes and oligonucleotides (1998) (41)
- Macrophage-like RAW 264 cell line and time-resolved fluoroimmunoassay (TRFIA) as tools in screening drug effects on cytokine secretion. (1995) (40)
- Decrease in Intracellular Concentration Causes the Shift in Km Value of Efflux Pump Substrates (2007) (40)
- The Cellular Uptake and Metabolism of Clodronate in RAW 264 Macrophages (2001) (37)
- Studies on liposome formulations for intra-articular delivery of clodronate (1995) (37)
- Inhibition of mevalonate pathway is involved in alendronate-induced cell growth inhibition, but not in cytokine secretion from macrophages in vitro. (2003) (36)
- Analysis of an adenine nucleotide-containing metabolite of clodronate using ion pair high-performance liquid chromatography-electrospray ionisation mass spectrometry. (2000) (33)
- Analysis of (dichloromethylene) bisphosphonate in urine by capillary gas chromatography-mass spectrometry. (1989) (32)
- Metabolic and Efflux Properties of Caco-2 Cells Stably Transfected with Nuclear Receptors (2006) (31)
- Distribution of [14C]clodronate (dichloromethylene bisphosphonate) disodium in mice. (1987) (31)
- The effects of liposome surface charge and size on the intracellular delivery of clodronate and gallium in vitro (1994) (31)
- Kinetics of Cellular Retention during Caco-2 Permeation Experiments: Role of Lysosomal Sequestration and Impact on Permeability Estimates (2009) (30)
- Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells (2015) (29)
- Activation of gammadelta T Cells by Bisphosphonates (2010) (29)
- Targeting Efficiency and Biodistribution of Zoledronate Conjugated Docetaxel Loaded Pegylated PBCA Nanoparticles for Bone Metastasis (2012) (28)
- Influence of lipids on the mannitol flux during transdermal iontophoresis in vitro. (2000) (28)
- Effect of locally administered zoledronic acid on injury-induced intramembranous bone regeneration and osseointegration of a titanium implant in rats (2009) (27)
- Modelling of drug disposition kinetics in in vitro intestinal absorption cell models. (2010) (27)
- Effects of liposome-encapsulated bisphosphonates on acetylated LDL metabolism, lipid accumulation and viability of phagocyting cells. (1997) (27)
- Effects of clodronate and pamidronate on splenic and hepatic phagocytic cells of mice. (1991) (26)
- Apoptosis-induced anticancer effect of transferrin-conjugated solid lipid nanoparticles of curcumin (2012) (25)
- Transdermal delivery of levosimendan. (2000) (24)
- Characterization of Caco-2 cell monolayer drug transport properties by cassette dosing using UV/fluorescence HPLC. (2004) (21)
- Human breast cancer cells educate macrophages toward the M 2 activation status (20)
- Effects of experimental setup on the apparent concentration dependency of active efflux transport in in vitro cell permeation experiments. (2010) (20)
- Lysosomal-Mitochondrial Axis in Zoledronic Acid-induced Apoptosis in Human Follicular Lymphoma Cells* (2009) (20)
- Oxidative stress plays an important role in zoledronic acid-induced autophagy. (2014) (19)
- Cartilage oligomeric matrix protein (COMP) is modified by intra-articular liposomal clodronate in an experimental model of arthritis. (2006) (19)
- Synthesis and Preclinical Pharmacology of 2-(2-Aminopyrimidinio) Ethylidene-1,1-Bisphosphonic Acid Betaine (ISA-13-1)-A Novel Bisphosphonate (1999) (18)
- Effects of calcium and lipophilicity on transport of clodronate and its esters through Caco-2 cells. (2001) (18)
- Selective Calcium-Dependent Inhibition of ATP-Gated P2X3 Receptors by Bisphosphonate-Induced Endogenous ATP Analog ApppI (2017) (17)
- Targeted delivery via avidin fusion protein: intracellular fate of biotinylated doxorubicin derivative and cellular uptake kinetics and biodistribution of biotinylated liposomes. (2012) (16)
- Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells. (2011) (16)
- Toxicity of gamma irradiated liposomes. 1. In vitro interactions with blood components. (1999) (15)
- Cellular uptake and metabolism of clodronate and its derivatives in Caco-2 cells: a possible correlation with bisphosphonate-induced gastrointestinal side-effects. (2003) (14)
- Toxicity of gamma irradiated liposomes. 2. In vitro effects on cells in culture. (1999) (13)
- In vitro and in vivo effects of tetrakisphosphonates on bone resorption, tumor osteolysis, ectopic calcification, and macrophages. (1997) (12)
- Uptake of free, calcium-bound and liposomal encapsulated nitrogen containing bisphosphonates by breast cancer cells. (2016) (11)
- The effect of free gallium and gallium in liposomes on cytokine and nitric oxide secretion from macrophage-like cells in vitro (1995) (10)
- The tissue distribution of clodronate (dichloromethylene bisphosphonate) in mice. The effects of vehicle and the route of administration (1990) (9)
- Determination of permeation resistance distribution in in vitro cell monolayer permeation experiments. (2010) (9)
- Comparison of pharmacokinetics of clodronate after single and repeated doses. (1999) (8)
- Upregulation of the mevalonate pathway by cholesterol depletion abolishes tolerance to N-bisphosphonate induced Vγ9Vδ2 T cell cytotoxicity in PC-3 prostate cancer cells. (2015) (8)
- Effect of N-betainate and N-piperazine derivatives of chitosan on the paracellular transport of mannitol in Caco-2 cells. (2008) (8)
- Liposome-Mediated Delivery of Gallium to Macrophage-Like Cells in Vitro: Demonstration of a Transferrin-Independent Route for Intracellular Delivery of Metal Ions (1993) (7)
- Suppression of viability and acetyl-LDL metabolism in RAW 264 macrophage-like and smooth muscle cells by bisphosphonates in vitro. (2002) (6)
- Effects of Bisphosphonates on the Inflammatory Processes of Activated Macrophages (1999) (5)
- Butyrophilin 3 A 1 Plays an Essential Role in Prenyl Pyrophosphate Stimulation of Human V g 2 V d 2 T Cells (2013) (5)
- Protein concentration and pH affect the apparent P-glycoprotein-ATPase activation kinetics. (2008) (5)
- Zoledronate-Induced IPP/ApppI (Phosphoantigen) Accumulation in Human Breast Cancer Cells Correlates with Vγ9VΔ2 T Cell-Mediated Cancer Cell Death In Vitro and In Vivo (2010) (4)
- Effects of alendronate on macrophage growth and pro-inflammatory cytokine production (1995) (3)
- Growth Inhibition of Macrophage-like and Other Cell Types by Liposome-encapsulated, Calcium-bound, and Free Bisphosphonates In Vitro (2003) (2)
- Liposomes--an invaluable tool in bisphosphonate research. (2002) (2)
- Different effects of three bisphosphonates on nitric oxide production by macrophages (1995) (1)
- Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate recognition by human V{gamma}2V{delta}2 T cells (P5051) (2013) (1)
- Synergistic inhibition of osteosarcoma cell growth by combination of RAD001 (everolimus) and zoledronic acid (2009) (1)
- Zoledronic acid induced IPP/ApppI accumulation in different cancer cell lines (2006) (1)
- Corrigendum to “Regulation of MMP-9 (gelatinase B) in activated human monocyte/macrophages by two different types of bisphosphonates” [Life Sciences 73 (2003) 2413–2420] (2004) (1)
- The distribution of three bisphosphonates in mice (1990) (1)
- Gamma-delta T cells (WS-094) Chairpersons: Yoshimasa Tanaka, Marc Bonneville (2010) (0)
- Opsonization, Biodistribution, Cellular Uptake and Apoptosis Study of PEGylated PBCA Nanoparticle as Potential Drug Delivery Carrier (2011) (0)
- Nitrogen-containing bisphosphonates induce IPP/DMAPP accumulation selectively in peripheral blood monocytes due to efficient drug uptake (2008) (0)
- Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate recognition by human Vγ2Vδ2 T cells (P5051) (2013) (0)
- Modulation of macrophage activation status by bisphosphonates and breast cancer cells (2013) (0)
- Use of bisphosphonates in the treatment of vascular resistance. (1999) (0)
- Human breast cancer cells educate macrophages toward the M2 activation status (2015) (0)
- Targeting of apoptotic pathways in cancer cells by zoledronic acid (2008) (0)
- Zoledronic acid induces IPP accumulation and release from human cancer cells, which activates Vγ9Vδ2 T cell-differentiation and migration in vitro and mediates Vγ9Vδ2 T cell-induced cancer cell death in vivo (2011) (0)
- P49. Zoledronic acid-induced IPP accumulation in cancer cells strongly correlates with γδ T-cell mediated cancer cell death (2008) (0)
- 179 Effects of human breast cancer cells secreted factors on macrophage differentiation (2014) (0)
- Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells (2015) (0)
- Rebuilding East and North (2014) (0)
- Professor Arto Urtti -A northern light from the land of the midnight sun. (2017) (0)
- Erratum to: Opsonization, Biodistribution, Cellular Uptake and Apoptosis Study of PEGylated PBCA Nanoparticle as Potential Drug Delivery Carrier (2011) (0)
- Effects of bisphosphonates on the acetyl-LDL metabolism and viability of phagocyting cells (1995) (0)
- Corrigendum to "Transferrin mediated solid lipid nanoparticles containing curcumin: Enhanced in-vitro anticancer activity by induction of apoptosis". [Int. J. Pharmac. 398 (2010) 190-203]. (2022) (0)
- Abstract 2154: Bone metastasis targeting: a novel approach to reach bone using zoledronate anchored nanoparticles loaded with docetaxel. (2013) (0)
- Assessment of bisphosphonate activity in vitro. (2010) (0)
- MetabolismCells through Alterations in Isoprenoid 2 T d 2V g Indirect Stimulation of Human V (2011) (0)
- Zoledronic acid-induced IPP accumulation in cancer cells strongly correlates with gammadelta T-Cell mediated cancer cell death (2008) (0)
- IPP/ApppI production and cellular drug uptake in synergistic action of doxorubicin and zoledronic acid (2006) (0)
- Clodronateof its Use in Breast Cancer (1999) (0)
- Uptake of different nitrogen containing bisphosphonate formulations by breast cancer cells (2016) (0)
- Zoledronic acid induces IPP release from cancer cells which causes Vgamma9Vdelta2 T cell expansion in PBMCs (2010) (0)
This paper list is powered by the following services:
Other Resources About Jukka Mönkkönen
What Schools Are Affiliated With Jukka Mönkkönen?
Jukka Mönkkönen is affiliated with the following schools:
