Junying Yuan
#59,134
Most Influential Person Now
American biologist
Junying Yuan's AcademicInfluence.com Rankings
Junying Yuanbiology Degrees
Biology
#2776
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#4359
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#1207
USA Rank
Molecular Biology
#388
World Rank
#395
Historical Rank
#133
USA Rank
Genetics
#399
World Rank
#463
Historical Rank
#170
USA Rank
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Biology
Junying Yuan's Degrees
- Bachelors Biology University of California, Berkeley
- Masters Genetics Stanford University
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Why Is Junying Yuan Influential?
(Suggest an Edit or Addition)According to Wikipedia, Junying Yuan is the Elizabeth D. Hay Professor of Cell Biology at Harvard Medical School, best known for her work in cell death. Early in her career, she contributed significant findings to the discovery and characterization of apoptosis. More recently, she was responsible for the discovery of the programmed form of necrotic cell death known as necroptosis.
Junying Yuan's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis (1998) (4668)
- Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β (2000) (3305)
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018) (3106)
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012) (2913)
- Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009 (2005) (2802)
- Fission and selective fusion govern mitochondrial segregation and elimination by autophagy (2008) (2626)
- The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme (1993) (2592)
- Human ICE/CED-3 Protease Nomenclature (1996) (2484)
- Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury (2005) (2344)
- Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 (2011) (2295)
- Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes (2009) (2078)
- Apoptosis in the nervous system (2000) (1861)
- Autophagy in cell death: an innocent convict? (2005) (1740)
- Identification of RIP1 kinase as a specific cellular target of necrostatins. (2008) (1702)
- Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3 (1993) (1457)
- A decade of caspases (2003) (1133)
- Molecular definitions of autophagy and related processes (2017) (1036)
- Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway (2008) (932)
- Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia (1998) (930)
- Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death (1994) (838)
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 (2021) (811)
- A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress (2005) (806)
- Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 (2014) (799)
- Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICE (1998) (721)
- A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. (2005) (708)
- Necroptosis as an alternative form of programmed cell death. (2010) (681)
- Mechanisms of pre‐apoptotic calreticulin exposure in immunogenic cell death (2009) (671)
- Prevention of vertebrate neuronal death by the crmA gene. (1994) (651)
- Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease (1999) (642)
- Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13 (2011) (640)
- Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis (2003) (617)
- Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade (1998) (583)
- Cross-Talk between Two Cysteine Protease Families (2000) (564)
- Expansion and evolution of cell death programmes (2008) (552)
- Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease (2010) (537)
- Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity. (2013) (537)
- The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death. (1990) (535)
- Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL (2001) (534)
- Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders (2003) (519)
- Cell death assays for drug discovery (2011) (510)
- Small-Molecule Inhibition of the Interaction between the Translation Initiation Factors eIF4E and eIF4G (2007) (499)
- Diversity in the Mechanisms of Neuronal Cell Death (2003) (495)
- The PHD Finger of the Chromatin-Associated Protein ING2 Functions as a Nuclear Phosphoinositide Receptor (2003) (489)
- Solution Structure of BID, an Intracellular Amplifier of Apoptotic Signaling (1999) (487)
- Small molecule regulators of autophagy identified by an image-based high-throughput screen (2007) (457)
- Regulation of Intracellular Accumulation of Mutant Huntingtin by Beclin 1* (2006) (455)
- Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death (2013) (452)
- Caspase-8 Is Required for Cell Death Induced by Expanded Polyglutamine Repeats (1999) (430)
- Shigella-induced Apoptosis Is Dependent on Caspase-1 Which Binds to IpaB* (1998) (412)
- Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases (2018) (403)
- The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death. (1992) (387)
- RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS (2016) (378)
- Activation of necroptosis in multiple sclerosis. (2015) (372)
- Expression of a Dominant Negative Mutant of Interleukin-1β Converting Enzyme in Transgenic Mice Prevents Neuronal Cell Death Induced by Trophic Factor Withdrawal and Ischemic Brain Injury (1997) (366)
- Inhibition of ICE slows ALS in mice (1997) (343)
- Necroptosis in health and diseases. (2014) (334)
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018) (323)
- Dual Role of Caspase-11 in Mediating Activation of Caspase-1 and Caspase-3 under Pathological Conditions (2000) (320)
- Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation (2002) (311)
- Alternative cell death mechanisms in development and beyond. (2010) (299)
- Transducing signals of life and death. (1997) (297)
- Caspase Cascades in Human Immunodeficiency Virus-Associated Neurodegeneration (2002) (296)
- Selective Inhibition of Eukaryotic Translation Initiation Factor 2α Dephosphorylation Potentiates Fatty Acid-induced Endoplasmic Reticulum Stress and Causes Pancreatic β-Cell Dysfunction and Apoptosis* (2006) (296)
- Autophagy in major human diseases (2021) (282)
- Necrostatin-1 Reduces Histopathology and Improves Functional Outcome after Controlled Cortical Impact in Mice (2008) (257)
- Processing and Activation of Pro-Interleukin-16 by Caspase-3* (1998) (256)
- Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology (2012) (255)
- Attenuation of Transient Focal Cerebral Ischemic Injury in Transgenic Mice Expressing a Mutant ICE Inhibitory Protein (1997) (247)
- Identification and Characterization of Ich-3, a Member of the Interleukin-1β Converting Enzyme (ICE)/Ced-3 Family and an Upstream Regulator of ICE* (1996) (246)
- Chaperone-mediated autophagy is involved in the execution of ferroptosis (2019) (246)
- TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging (2018) (240)
- A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. (2010) (234)
- Prolonged Therapeutic Window for Ischemic Brain Damage Caused by Delayed Caspase Activation (1998) (226)
- Specific Cleavage of α-Fodrin during Fas- and Tumor Necrosis Factor-induced Apoptosis Is Mediated by an Interleukin-1β-converting Enzyme/Ced-3 Protease Distinct from the Poly(ADP-ribose) Polymerase Protease* (1996) (226)
- Necroptosis, a novel form of caspase‐independent cell death, contributes to neuronal damage in a retinal ischemia‐reperfusion injury model (2009) (221)
- Autophagy Limits Listeria monocytogenes Intracellular Growth in the Early Phase of Primary Infection (2007) (215)
- Necroptosis in development and diseases (2018) (210)
- RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease (2017) (209)
- The Jekyll and Hyde functions of caspases. (2009) (208)
- Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke (2009) (207)
- Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1 (2008) (204)
- Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival (2011) (198)
- Roles of Caspases in Necrotic Cell Death (2016) (194)
- Pharmacologic agents targeting autophagy. (2015) (193)
- Activation of Caspase-2 in Apoptosis* (1997) (190)
- Structure-activity relationship study of novel necroptosis inhibitors. (2005) (187)
- Targeting RIPK1 for the treatment of human diseases (2019) (187)
- Control of life-or-death decisions by RIP1 kinase. (2014) (184)
- Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis (2017) (184)
- Structural basis of RIP1 inhibition by necrostatins. (2013) (181)
- Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach (2015) (177)
- Salmonella-Induced Caspase-2 Activation in Macrophages A Novel Mechanism in Pathogen-Mediated Apoptosis (2000) (176)
- Control of basal autophagy by calpain1 mediated cleavage of ATG5 (2010) (166)
- Selective gating of visual signals by microstimulation of frontal cortex (162)
- Essential Role for Caspase-8 in Transcription-independent Apoptosis Triggered by p53* (2000) (160)
- Negative regulation of Vps34 by Cdk mediated phosphorylation. (2010) (157)
- Chaperone-mediated autophagy degrades mutant p53. (2013) (156)
- Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. (2007) (144)
- Suppression of Interleukin-1-converting Enzyme-mediated Cell Death by Insulin-like Growth Factor (*) (1996) (143)
- Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target (2020) (138)
- Antigen-mediated T cell expansion regulated by parallel pathways of death (2008) (137)
- Inhibition of Cellular Autophagy Deranges Dengue Virion Maturation (2012) (135)
- Nrdp1‐mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis (2004) (135)
- Upregulation of the Fas Receptor Death-Inducing Signaling Complex after Traumatic Brain Injury in Mice and Humans (2002) (135)
- Caspase-11 regulates cell migration by promoting Aip1–Cofilin-mediated actin depolymerization (2007) (132)
- Fas Receptor and Neuronal Cell Death after Spinal Cord Ischemia (2000) (132)
- A first insight into the molecular mechanisms of apoptosis (2004) (131)
- Caspase-11 Mediates Oligodendrocyte Cell Death and Pathogenesis of Autoimmune-Mediated Demyelination (2001) (131)
- Necroptosis and Cancer. (2017) (128)
- LKB1 — A master tumour suppressor of the small intestine and beyond (2002) (125)
- Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains (2010) (125)
- A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1 (2019) (122)
- Dual Role of Sumoylation in the Nuclear Localization and Transcriptional Activation of NFAT1* (2004) (120)
- A C. elegans E/Daughterless bHLH protein marks neuronal but not striated muscle development. (1997) (114)
- Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1. (2015) (111)
- Single-Cell RNA Sequencing: Unraveling the Brain One Cell at a Time. (2017) (108)
- Regulator of Calcineurin 1 (RCAN1) Facilitates Neuronal Apoptosis through Caspase-3 Activation* (2011) (107)
- Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expression (2018) (106)
- FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease. (2013) (105)
- ICE, neuronal apoptosis and neurodegeneration (1998) (105)
- Specific Proteolysis of the Kinase Protein Kinase C-related Kinase 2 by Caspase-3 during Apoptosis (1997) (104)
- Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5. (2007) (102)
- Beclin 1 Controls the Levels of p 53 by Regulating the Deubiquitination Activity of USP 10 and USP 13 (2011) (102)
- Evolutionary conservation of a genetic pathway of programmed cell death (1996) (102)
- A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors. (2002) (98)
- Molecular control of life and death. (1995) (97)
- Activation of necroptosis in human and experimental cholestasis (2016) (94)
- Interleukin-1β-converting Enzyme Mediates Cisplatin-induced Apoptosis in Malignant Glioma Cells (1995) (92)
- Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death (2015) (88)
- c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1. (2007) (88)
- Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis (2018) (85)
- Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy (2009) (84)
- USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1 (2016) (83)
- Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7. (2008) (82)
- Mitochondrial electron transport chain complex III is required for antimycin A to inhibit autophagy. (2011) (82)
- Caspase-11 Controls Interleukin-1β Release through Degradation of TRPC1 (2014) (82)
- Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity (2008) (79)
- Faculty Opinions recommendation of Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis. (2015) (79)
- A genome-wide RNAi screen reveals multiple regulators of caspase activation (2007) (79)
- Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis (2018) (78)
- Cyclophilin A release as a biomarker of necrotic cell death (2010) (77)
- Divergence from a dedicated cellular suicide mechanism: exploring the evolution of cell death. (2006) (77)
- Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system (2015) (77)
- PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP (2017) (75)
- Bcl-xS and Bax induce different apoptotic pathways in PC12 cells (2000) (75)
- Superoxide dismutase 1 mutants related to amyotrophic lateral sclerosis induce endoplasmic stress in neuro2a cells (2008) (74)
- A novel tracing algorithm for high throughput imaging Screening of neuron-based assays (2007) (72)
- Structure-activity relationship study of tricyclic necroptosis inhibitors. (2007) (71)
- G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L (2015) (70)
- TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL. (2019) (69)
- Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo. (2003) (69)
- Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon (2015) (67)
- Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke (2020) (66)
- FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation (2015) (66)
- Coordinated Expression of Caspase 8, 3 and 7 mRNA in Temporal Cortex of Alzheimer Disease: Relationship to Formic Acid Extractable A&bgr;42 Levels (2006) (65)
- A PHD Finger Motif in the C Terminus of RAG2 Modulates Recombination Activity*[boxs] (2005) (65)
- ABIN-1 Regulates RIPK1 Activation by Bridging M1 ubiquitination with K63 Deubiquitination in TNF-RSC (2017) (64)
- Sealing one's fate: control of cell death in neurons (1998) (64)
- Dissociation between Neurodegeneration and Caspase-11-Mediated Activation of Caspase-1 and Caspase-3 in a Mouse Model of Amyotrophic Lateral Sclerosis (2003) (64)
- Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation (2018) (62)
- Expression Cloning of Protein Targets for 3-Phosphorylated Phosphoinositides* (1999) (61)
- Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner. (2006) (61)
- Arctigenin preferentially induces tumor cell death under glucose deprivation by inhibiting cellular energy metabolism. (2012) (60)
- Small pool expression screening: identification of genes involved in cell cycle control, apoptosis, and early development. (1997) (59)
- Overexpression of the transmembrane tyrosine phosphatase LAR activates the caspase pathway and induces apoptosis (1998) (57)
- Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity. (2013) (53)
- Mechanisms of cell death in polyglutamine expansion diseases. (2004) (52)
- Need for caspases in apoptosis of trophic factor‐deprived PC12 cells (1997) (51)
- A Novel Small Molecule Regulator of Guanine Nucleotide Exchange Activity of the ADP-ribosylation Factor and Golgi Membrane Trafficking* (2008) (50)
- SnapShot: Necroptosis (2014) (49)
- Need for caspase‐2 in apoptosis of growth‐factor‐deprived PC12 cells (1998) (48)
- BRAF and AXL oncogenes drive RIPK3 expression loss in cancer (2018) (47)
- A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses (2009) (46)
- Prion Pathogenesis is Independent of Caspase-12 (2007) (46)
- Tc4, a Caenorhabditis elegans transposable element with an unusual fold-back structure. (1991) (46)
- reticulum-specific apoptosis and cytotoxicity by amyloid-b (2000) (45)
- USP25 regulates Wnt signaling by controlling the stability of tankyrases (2017) (44)
- SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination (2017) (44)
- The channel of death (2001) (42)
- Assays for necroptosis and activity of RIP kinases. (2014) (41)
- Automated neurite extraction using dynamic programming for high-throughput screening of neuron-based assays (2007) (41)
- Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. (2007) (39)
- Modulating TRADD to restore cellular homeostasis and inhibit apoptosis (2020) (38)
- Caspase activity sows the seeds of neuronal death (1999) (37)
- LKB1 is crucial for TRAIL-mediated apoptosis induction in osteosarcoma. (2007) (36)
- Live imaging and single-cell analysis reveal differential dynamics of autophagy and apoptosis (2013) (34)
- SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation (2021) (34)
- Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners (2020) (34)
- Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. (2005) (34)
- Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 (2016) (33)
- Role of Protein Misfolding in DFNA9 Hearing Loss* (2010) (32)
- Ketogenic diet effects on neurobehavioral development of children with intractable epilepsy: A prospective study (2016) (31)
- Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652 (2016) (31)
- Parkin regulates NF-κB by mediating site-specific ubiquitination of RIPK1 (2018) (31)
- α-Synuclein oligomerization: a role for lipids? (2003) (30)
- Anti-apogens and anti-engulfens: monoclonal antibodies reveal specific antigens on apoptotic and engulfment cells during chicken embryonic development. (1994) (30)
- A Convoluted Way to Die (2001) (30)
- Inhibition of cell migration by PITENINs: the role of ARF6 (2011) (27)
- Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death (2018) (25)
- A novel necroptosis inhibitor-necrostatin-21 and its SAR study. (2013) (23)
- Inactivation of farnesyltransferase and geranylgeranyltransferase I by caspase-3: Cleavage of the common α subunit during apoptosis (2001) (23)
- Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinoma (2020) (21)
- Gentamicin-Induced Acute Kidney Injury in an Animal Model Involves Programmed Necrosis of the Collecting Duct. (2020) (21)
- Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers. (2011) (21)
- ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells. (2008) (20)
- Small molecule probes for cellular death machines. (2017) (20)
- Inhibition of cIAP1 as a strategy for targeting c-MYC–driven oncogenic activity (2018) (19)
- Life and death in paradise (2002) (19)
- Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors. (2008) (19)
- Casein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3 (2019) (18)
- Suppression of Interleukin-1β converting enzyme (ICE)-induced apoptosis by SV40 large T antigen (1997) (18)
- Mechanisms of programmed cell death in Caenorhabditis elegans and vertebrates. (1996) (18)
- Activation of chaperone-mediated autophagy as a potential anticancer therapy (2015) (17)
- A RIPK1-regulated inflammatory microglial state in amyotrophic lateral sclerosis (2021) (17)
- Identification of Small Molecule Inhibitors of Neurite Loss Induced by Aβ peptide using High Content Screening* (2012) (17)
- ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner (2018) (16)
- RIPK1 Promotes Energy Sensing by the mTORC1 Pathway. (2020) (16)
- MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response (2020) (15)
- Reduction of mNAT1/hNAT2 Contributes to Cerebral Endothelial Necroptosis and Aβ Accumulation in Alzheimer's Disease. (2020) (15)
- ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC (2017) (14)
- Alpha-synuclein oligomerization: a role for lipids? (2003) (14)
- Lithium Treatment Is Safe in Children With Intellectual Disability (2018) (14)
- Modification of protein sub-nuclear localization by synthetic phosphoinositides: evidence for nuclear phosphoinositide signaling mechanisms. (2005) (13)
- Genetic control of cellular suicide. (1997) (13)
- Erratum: Autophagy in cell death: An innocent convict? (Journal of Clinical Investigation (2005) 115, (2679-2688) DOI:101172/JCI26390) (2006) (12)
- Paediatric cerebral palsy prevalence and high-risk factors in Henan province, Central China. (2019) (12)
- Caspase-11 is not necessary for chemotherapy-induced intestinal mucositis. (2004) (12)
- Optimization of tricyclic Nec-3 necroptosis inhibitors for in vitro liver microsomal stability. (2012) (12)
- A computational framework for studying neuron morphology from in vitro high content neuron-based screening (2010) (12)
- Genetic Regulation of RIPK1 and Necroptosis. (2021) (12)
- Parcs Is a Dual Regulator of Cell Proliferation and Apaf-1 Function* (2008) (12)
- Transient transfection assay of cell death genes. (2000) (11)
- Necroptosis activates UPR sensors without disrupting their binding with GRP78 (2021) (9)
- NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation (2021) (9)
- Structure-activity relationship study of E6 as a novel necroptosis inducer. (2015) (9)
- An image based system biology approach for Alzheimer's disease pathway analysis (2009) (8)
- Discovery of a cooperative mode of inhibiting RIPK1 kinase (2021) (8)
- Structure—Activity Relationship Analysis of a Novel Necroptosis Inhibitor, Necrostatin-5 (VIa). (2007) (7)
- Phase I study of A166 in patients with HER2-expressing locally advanced or metastatic solid tumors. (2021) (7)
- Synthetic Study of Substituted Arylsulfonylphenylbenzamides (2005) (6)
- Insights into Trx1, TRP14, and Prx1 homologs of Paralichthys olivaceus: molecular profiles and transcriptional responses to immune stimulations (2016) (6)
- Identification of a small molecule activator of novel PKCs for promoting glucose-dependent insulin secretion (2011) (6)
- Releasing the nerve cell killers (2002) (6)
- Erratum: Corrigendum: Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury (2005) (6)
- Corrigendum: Chaperone-mediated autophagy degrades mutant p53. (2016) (6)
- A degradative detour for mutant TP53 (2013) (5)
- Regulations of Programmed Cell Death by Interleukin-1β-Converting Enzyme Family of Proteases (1996) (5)
- Correction: Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death (2016) (5)
- Erratum: Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma (Ecography (2007) 21 (98-111)) (2007) (5)
- Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies (2011) (5)
- A new and efficient synthesis of wedelolactone derivatives (2010) (4)
- Necroptosis - A novel cell death mechanism (2008) (4)
- Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis (2017) (4)
- Suppression of Interleukin-1b-converting Enzyme-mediated Cell Death by Insulin-like Growth Factor* (1996) (4)
- Salmonella-Induced Caspase-2 Activation in Macrophages (2000) (4)
- Expression of apogens and engulfens during programmed cell death in the nervous system of the chick embryo. (1995) (4)
- Regulation of programmed cell death by interleukin-1 beta-converting enzyme family of proteases. (1996) (3)
- Inducing autophagy harmlessly (2008) (3)
- Intraventricular Administration of a Caspase Inhibitor Delays Disease Progression and Mortality in a Mouse Model of Huntington's Disease (1999) (3)
- Quantitative analysis of phosphoproteome in necroptosis reveals a role of TRIM28 phosphorylation in promoting necroptosis-induced cytokine production (2021) (3)
- glioblastoma Bcl 2 L 12 inhibits post-mitochondrial apoptosis signaling in Material Supplemental (2006) (3)
- Apoptosis: Endoplasmic Reticulum Stress Response in Cell Death and Cell Survival (2011) (3)
- Cell biology: Death by deacetylation (2012) (2)
- THE ROLE OF PROTEIN MISFOLDING IN DFNA 9 HEARING LOSS (2010) (2)
- Caspase inhibition prolongs inflammation by promoting a signaling complex with activated RIPK1 (2021) (2)
- Author response: Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system (2015) (2)
- A Cellular Response to an Internal Energy Crisis (2005) (2)
- Postoperative choroidal hemorrhage shows elevated concentration of tissue plasminogen activator. (2012) (2)
- Population Pharmacokinetics of Lithium in Young Pediatric Patients With Intellectual Disability (2021) (1)
- ICH‐3, an upstream regulator of ICE, plays a critical role in regulating inflammation and apoptosis induced by inflammatory responses.: 451 (1997) (1)
- Regulated cell death part A: apoptotic mechanisms. Preface. (2014) (1)
- Non-Self-Sealing (Leaky) Anterior Chamber Paracentesis: A New Technique in Managing Postphacoemulsification Intraocular Pressure Rise in Glaucoma and Normal Eyes. (2018) (1)
- A Novel Small Molecule Regulator of Guanine Nucleotide Exchange Activity of ARF and Golgi Membrane Trafficking (2008) (1)
- eview ecroptosis in health and diseases (2014) (1)
- Systematic Metrics Depicting Cell Death Kinetics. (2017) (1)
- To kill or to arrest: that is the new question for Apaf-1. (2007) (1)
- Loss of MLL induces epigenetic dysregulation of Rasgrf1 to attenuate Kras-driven lung tumorigenesis. (2022) (1)
- USP5-Beclin 1 axis overrides p53-dependent senescence and drives Kras-induced tumorigenicity (2022) (1)
- Methods in Enzymology. Regulated cell death part B--necroptotic, autophagic and other non-apoptotic mechanisms. Preface. (2014) (1)
- G-protein-coupled receptors regulate autophagy by ZBTB 16-mediated ubiquitination and proteasomal degradation of Atg 14 (2015) (1)
- Corrigendum: SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination. (2018) (1)
- A new savior for neurons (1999) (1)
- Regulated Cell Death (2021) (1)
- Targeting RIPK1 kinase for modulating inflammation in human diseases (2023) (1)
- Abstract SY09-01: Control of class III PI 3-kinase in autophagy and cancers (2011) (0)
- Structure—Activity Relationship Studies of Salubrinal Lead to Its Active Biotinylated Derivative. (2005) (0)
- RIP3 Regulates Acute Cholestasis-Associated Necroptotic Signaling and Cell Death (2016) (0)
- Application of a small pool cloning method to identification of substrate candidates for caspases (1998) (0)
- Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death (2018) (0)
- HUMAN PRO-APOPTOTIC PROTEIN BID (2000) (0)
- Necrostatin-1: Its Discovery and Application in Cell Death Research (2014) (0)
- Endoscopic diagnosis and therapy for cystic tumors in duodenum (2008) (0)
- Diagnosis and therapy of benign upper gastrointestinal protruding lesions using endoscopic ultrasonography: an analysis of 118 cases (2009) (0)
- Endoscopic ultrasound in combination with pathological examination for diagnosis of duodenal Brunner’s gland hyperplasia and selection of appropriate endoscopic treatment (2010) (0)
- Research and Development of Antibacterial Metallic Materials (2015) (0)
- ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner (2018) (0)
- Enzyme de conversion de l'interleukine (ice) et lesions du snc (1998) (0)
- P1193 : Necroptosis contributes to the pathogenesis of cholestatic liver injury (2015) (0)
- JNK signaling: A possible mechanism of beta-amyloid toxicity (2010) (0)
- Clinical application of the ICF core set for cerebral palsy children (2018) (0)
- The roads to Stockholm: On the 2002 Nobel Prize in Physiology or Medicine (2003) (0)
- The role of caspase-12 in mediating an ER-specific apoptosis pathway and abeta protein neurototoxicity (2000) (0)
- Negative Regulation of Vps 34 by Cdk Mediated Phosphorylation Citation (2012) (0)
- Cellular Apoptosis Induced by Deoxynivalenol (2021) (0)
- Synthetic Study of Substituted Arylsulfonylphenylbenzamides. (2005) (0)
- Apoptosis: Cell Death in Nervous System Development and Neurological Disease (2011) (0)
- Small molecule “on” and “off” switches for autophagy (2012) (0)
- Inhibitionof caspase-1 slowsdiseaseprogression inamousemodel ofHuntington ’ sdisease (0)
- Regulation of Apoptosis by Caspases (1999) (0)
- Impact of the peripheral neurotomy method combined with rehabilitation exercise on gross motor function and balance function of children with cerebral palsy (2014) (0)
- A novel member of Ice/ced-3 family from mouse (1996) (0)
- Parkin regulates NF-κB by mediating site-specific ubiquitination of RIPK1 (2018) (0)
- Factors affecting the prognosis for children in a persistent vegetative state (2016) (0)
- Effects of ginkgobalide B on neurocyte apoptosis and the expression of protein kinase B after experimental hypoxic-ischemic brain injury (2017) (0)
- Synapshot, From Gene to Drug Treatment (1995) (0)
- The Endoplasmic Reticulum Stress Response in Health and Disease (2003) (0)
- Abstract SY31-03: Global signaling mechanisms that regulate autophagy (2010) (0)
- The expression changes and role of hypoxia-inducible factor-1α in the early stage of hypoxic-ischemic brain damage in neonatal rats (2017) (0)
- Reductin of Post-traumatic Brain Injury and Free Radical Production by Inhibition of the ICE Apoptosis Cascade (1998) (0)
- Cell division, growth and death (2002) (0)
- Abstract SY36-03: Development of small-molecule inhibitors of autophagy as anticancer therapy (2012) (0)
- The effects of conductive education on gross motor function and Gesell development test results in children with cerebral palsy (2014) (0)
- Junying Yuan: changing avenues without losing focus. Interview by Nicole LeBrasseur. (2007) (0)
- 726 VIRTUAL TOUCH TISSUE QUANTIFICATION FOR NONINVASIVE ASSESSMENT OF LIVER FIBROSIS IN CHRONIC HEPATITIS B (2013) (0)
- Summary The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death (0)
- A Novel Small Molecule Regulator of Guanine Nucleotide Exchange Activity of ARF and Golgi Membrane Trafficking * 8 / 11 / 2008 (2008) (0)
- Abstract SY27-03: Development of necrostatins, small molecule inhibitors of RIP1-kinase signaling and necroptosis (2012) (0)
- Junying Yuan: Changing avenues without losing focus (2007) (0)
- Inhibition of transient focal cerebral ischemic injury in mice expressing an inhibitor of the ICE apoptosis gene in neurons: 800 (1997) (0)
- Proteases to die for Vincent Cryns (1998) (0)
- Modulating TRADD to restore cellular homeostasis and inhibit apoptosis (2020) (0)
- Caspase‐8 regulates a form of death that is distinct from apoptosis in T cells (2008) (0)
- P3-208 Role of caspase family proteases in amyloid beta-induced neuronal death (2004) (0)
- Studying mechanisms of cell death: from apoptosis to necrosis (2007) (0)
- Activation and Modulation of the ICE Aapoptosis Gene in ALS, a Novel Therapeutic Intervention.: 783 (1997) (0)
- SOLUTION STRUCTURE OF APAF-1 CARD (1999) (0)
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