Jürg Tschopp

Q: What Schools Are Affiliated With Jürg Tschopp

Jürg Tschopp is affiliated with the following schools: University of Alabama at Birmingham, University of Lausanne, University of Amsterdam, University of Oxford, University of Basel, University of Adelaide, University of Geneva

Jürg Tschopp's AcademicInfluence.com Rankings

Jürg Tschopp

Biology

#2259

World Rank

#3613

Historical Rank

Biochemistry

#194

World Rank

#244

Historical Rank

biology Degrees

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Biology

Jürg Tschopp's Degrees

PhD Biochemistry University of Basel

Why Is Jürg Tschopp Influential?

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According to Wikipedia, Jürg Tschopp was a Swiss biochemist, known for his research on apoptosis and the immunology of inflammation. His greatest achievement was perhaps his team's discovery and scientific description of the inflammasome .

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Jürg Tschopp's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. (2002) (4996)
Gout-associated uric acid crystals activate the NALP3 inflammasome (2006) (4526)
The Inflammasomes (2010) (3869)
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009 (2005) (2802)
Inhibition of death receptor signals by cellular FLIP (1997) (2782)
A role for mitochondria in NLRP3 inflammasome activation (2011) (2738)
Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes (2003) (2460)
Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica (2008) (2447)
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus (2005) (2398)
The inflammasomes: guardians of the body. (2009) (2264)
Thioredoxin-interacting protein links oxidative stress to inflammasome activation (2010) (2119)
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes (2009) (2078)
Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule (2000) (1750)
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. (2004) (1667)
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors (2009) (1606)
Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations (1999) (1531)
NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? (2010) (1529)
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors (1997) (1406)
BAFF, a Novel Ligand of the Tumor Necrosis Factor Family, Stimulates B Cell Growth (1999) (1368)
Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape (1996) (1354)
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration (2007) (1322)
Intracellular pattern recognition receptors in the host response (2006) (1191)
Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways (1994) (1137)
Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin. (1998) (1065)
The NLRP3 Inflammasome: A Sensor for Metabolic Danger? (2010) (997)
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response (2008) (994)
Inflammatory Caspases Linking an Intracellular Innate Immune System to Autoinflammatory Diseases (2004) (968)
Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome. (2002) (915)
BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF (2001) (902)
The molecular architecture of the TNF superfamily. (2002) (865)
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence (2009) (859)
Conversion of Membrane-bound Fas(CD95) Ligand to Its Soluble Form Is Associated with Downregulation of Its Proapoptotic Activity and Loss of Liver Toxicity (1998) (838)
Type I interferon inhibits interleukin-1 production and inflammasome activation. (2011) (835)
NF-κB Signals Induce the Expression of c-FLIP (2001) (806)
Inflammatory caspases and inflammasomes: master switches of inflammation (2007) (772)
NALPs: a novel protein family involved in inflammation (2003) (766)
Baff Mediates Survival of Peripheral Immature B Lymphocytes (2000) (758)
A pilot study of IL-1 inhibition by anakinra in acute gout (2007) (721)
Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. (1998) (718)
TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB. (1997) (709)
The inflammasome: a danger sensing complex triggering innate immunity. (2007) (705)
The inflammasome: an integrated view (2011) (694)
MyD88, an Adapter Protein Involved in Interleukin-1 Signaling* (1998) (688)
NLRs join TLRs as innate sensors of pathogens. (2005) (688)
Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes (1991) (686)
TRAIL receptor-2 signals apoptosis through FADD and caspase-8 (2000) (675)
The PIDDosome, a Protein Complex Implicated in Activation of Caspase-2 in Response to Genotoxic Stress (2004) (649)
Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome (2010) (639)
Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome (2008) (617)
The caspase-8 inhibitor FLIP promotes activation of NF-κB and Erk signaling pathways (2000) (610)
Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome (2004) (600)
Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation (2011) (579)
Inhibition of fas death signals by FLIPs. (1998) (567)
RIP1 is an essential mediator of Toll-like receptor 3–induced NF-κB activation (2004) (566)
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor (2000) (564)
The CARD domain: a new apoptotic signalling motif. (1997) (547)
Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. (2013) (541)
Inhibition of Interleukin 1 Receptor/Toll-like Receptor Signaling through the Alternatively Spliced, Short Form of MyD88 Is Due to Its Failure to Recruit IRAK-4 (2003) (541)
Quantitative proteomics reveals subset-specific viral recognition in dendritic cells. (2010) (541)
Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death). (1993) (532)
APRIL, a New Ligand of the Tumor Necrosis Factor Family, Stimulates Tumor Cell Growth (1998) (529)
Caspase Activation Is Required for T Cell Proliferation (1999) (528)
Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome (2009) (519)
The Long Form of FLIP Is an Activator of Caspase-8 at the Fas Death-inducing Signaling Complex* (2002) (509)
Caspase-1 Activation of Lipid Metabolic Pathways in Response to Bacterial Pore-Forming Toxins Promotes Cell Survival (2006) (508)
Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β (2010) (487)
Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover (1996) (476)
Inflammasome Components NALP 1 and 3 Show Distinct but Separate Expression Profiles in Human Tissues Suggesting a Site-specific Role in the Inflammatory Response (2007) (467)
Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation. (2012) (460)
Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1. (2012) (448)
The NLRP3 inflammasome promotes renal inflammation and contributes to CKD. (2010) (443)
Regulation of lymphocyte proliferation and death by flip (2001) (437)
Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain? (1997) (436)
Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum. (2000) (433)
Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses. (2006) (433)
Interactions of Tumor Necrosis Factor (TNF) and TNF Receptor Family Members in the Mouse and Human* (2006) (419)
Caspase-independent cell death in T lymphocytes (2003) (417)
A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses (2007) (410)
Recruitment of TNF Receptor 1 to Lipid Rafts Is Essential for TNFα-Mediated NF-κB Activation (2003) (406)
Ceramide Enables Fas to Cap and Kill* (2001) (404)
The CD95 Receptor: Apoptosis Revisited (2007) (403)
Baff Binds to the Tumor Necrosis Factor Receptor–Like Molecule B Cell Maturation Antigen and Is Important for Maintaining the Peripheral B Cell Population (2000) (400)
Two Adjacent Trimeric Fas Ligands Are Required for Fas Signaling and Formation of a Death-Inducing Signaling Complex (2003) (400)
The RIP kinases: crucial integrators of cellular stress. (2005) (399)
Expression of the lacZ gene from two methanol-regulated promoters in Pichia pastoris. (1987) (392)
Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid. (1989) (387)
RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. (2004) (387)
Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal (2009) (381)
Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity. (2007) (378)
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis (2011) (372)
A family of serine esterases in lytic granules of cytolytic T lymphocytes (1987) (372)
Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction. (2004) (367)
Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity (2011) (366)
Identification of proteoglycans as the APRIL-specific binding partners (2005) (360)
Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis. (2002) (351)
Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. (2009) (346)
Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4 (2010) (346)
Clusterin: the intriguing guises of a widely expressed glycoprotein. (1992) (340)
TRADD protein is an essential component of the RIG-like helicase antiviral pathway. (2008) (336)
CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation (2002) (335)
Innate Immune Sensing of Modified Vaccinia Virus Ankara (MVA) Is Mediated by TLR2-TLR6, MDA-5 and the NALP3 Inflammasome (2009) (334)
The TRAIL to selective tumor death (1999) (326)
Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease (1996) (326)
Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L). (1999) (320)
High–Level Expression and Efficient Assembly of Hepatitis B Surface Antigen in the Methylotrophic Yeast, Pichia Pastoris (1987) (319)
Identification of CARDIAK, a RIP-like kinase that associates with caspase-1 (1998) (314)
Differential Expression of NLRP3 among Hematopoietic Cells (2011) (307)
The neutrophil NLRC4 inflammasome selectively promotes IL-1β maturation without pyroptosis during acute Salmonella challenge. (2014) (302)
TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts. (2008) (299)
Regulation of Interleukin-1- and Lipopolysaccharide-Induced NF-κB Activation by Alternative Splicing of MyD88 (2002) (297)
TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95). (1997) (296)
cFLIP regulation of lymphocyte activation and development (2006) (296)
The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1β processing (2007) (295)
Type I IFN controls chikungunya virus via its action on nonhematopoietic cells (2010) (294)
ER stress activates the NLRP3 inflammasome via an UPR-independent pathway (2012) (294)
PIDD Mediates NF-κB Activation in Response to DNA Damage (2005) (289)
Isolation of a lytic, pore-forming protein (perforin) from cytolytic T-lymphocytes. (1985) (287)
DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF‐κB (2009) (284)
Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses (2008) (280)
Involvement of the proteasome in the programmed cell death of NGF‐deprived sympathetic neurons. (1996) (278)
Mitochondria: Sovereign of inflammation? (2011) (273)
The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation (2001) (269)
Perforin-mediated target cell lysis by cytolytic T lymphocytes. (1990) (264)
FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation. (1998) (260)
N-Terminal Fragment of c-FLIP(L) Processed by Caspase 8 Specifically Interacts with TRAF2 and Induces Activation of the NF-κB Signaling Pathway (2004) (258)
Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. (2000) (257)
Clusterin (complement lysis inhibitor) forms a high density lipoprotein complex with apolipoprotein A-I in human plasma. (1991) (257)
Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core Complex (2007) (256)
Granzymes, a Family of Serine Proteases Released from Granules of Cytolytic T Lymphocytes upon T Cell Receptor Stimulation (1988) (255)
A Soluble Form of B Cell Maturation Antigen, a Receptor for the Tumor Necrosis Factor Family Member April, Inhibits Tumor Cell Growth (2000) (253)
Maturation of Marginal Zone and Follicular B Cells Requires B Cell Activating Factor of the Tumor Necrosis Factor Family and Is Independent of B Cell Maturation Antigen (2001) (253)
The NLRP3 Inflammasome Is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia (2011) (252)
FAS Engagement Induces the Maturation of Dendritic Cells (Dcs), the Release of Interleukin (Il)-1β, and the Production of Interferon γ in the Absence of IL-12 during Dc–T Cell Cognate Interaction (2000) (251)
Signals from within: the DNA-damage-induced NF-κB response (2006) (248)
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes (2009) (248)
High-Level Secretion of Glycosylated Invertase in the Methylotrophic Yeast, Pichia Pastoris (1987) (244)
Wegener's autoantigen decoded (1990) (244)
T Cell Costimulation by the TNF Ligand BAFF1 (2001) (242)
Size distribution and general structural features of N‐linked oligosaccharides from the methylotrophic yeast, Pichia pastoris (1989) (242)
Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses (2010) (240)
Differential expression of perforin in muscle-infiltrating T cells in polymyositis and dermatomyositis. (1996) (240)
A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity. (1994) (238)
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins. (1991) (236)
Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome (2011) (233)
NALP Inflammasomes: a central role in innate immunity (2007) (225)
Granzyme A is an interleukin 1 beta-converting enzyme (1995) (223)
BAFF is a survival and maturation factor for mouse B cells (2002) (222)
Apoptosis induced by death receptors. (2000) (221)
Activated B cells express functional Fas ligand (1996) (219)
Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome. (2010) (215)
In Vitro– and Ex Vivo–derived Cytolytic Leukocytes from Granzyme A × B Double Knockout Mice Are Defective in Granule-mediated Apoptosis but not Lysis of Target Cells (1997) (213)
Mutations Leading to X-linked Hypohidrotic Ectodermal Dysplasia Affect Three Major Functional Domains in the Tumor Necrosis Factor Family Member Ectodysplasin-A* (2001) (211)
Carma1, a CARD‐containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF‐κB activation1 (2001) (207)
Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis. (2000) (201)
Tollip Regulates Proinflammatory Responses to Interleukin-1 and Lipopolysaccharide (2006) (197)
The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis (1994) (197)
MyD88S, a splice variant of MyD88, differentially modulates NF‐κB‐ and AP‐1‐dependent gene expression (2003) (196)
Characterization of Fas (Apo-1, CD95)-Fas Ligand Interaction* (1997) (196)
The fight of viruses against apoptosis. (1998) (194)
Monoclonal Antibodies Recognizing a Neoantigen of Poly(C9) Detect the Human Terminal Complement Complex in Tissue and Plasma (1985) (193)
Characterization of two receptors for TRAIL. (1997) (191)
Structural/functional similarity between proteins involved in complement- and cytotoxic T-lymphocyte-mediated cytolysis (1986) (191)
The role of interleukin-1 and the inflammasome in gout: implications for therapy. (2007) (189)
Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation. (2003) (188)
Cutting edge: a novel viral TNF receptor superfamily member in virulent strains of human cytomegalovirus. (1999) (187)
Signals from within: the DNA-damage-induced NF-kappaB response. (2006) (184)
PIDD mediates NF-kappaB activation in response to DNA damage. (2005) (179)
Clusterin gene expression mediates resistance to apoptotic cell death induced by heat shock and oxidative stress. (1999) (179)
TNF Deficiency Fails to Protect BAFF Transgenic Mice against Autoimmunity and Reveals a Predisposition to B Cell Lymphoma1 (2004) (178)
BAFF production by antigen-presenting cells provides T cell co-stimulation. (2004) (176)
Oncogenic Ras inhibits Fas ligand‐mediated apoptosis by downregulating the expression of Fas (1999) (175)
Human clusterin gene expression is confined to surviving cells during in vitro programmed cell death. (1994) (175)
Clusterin, the human apolipoprotein and complement inhibitor, binds to complement C7, C8 beta, and the b domain of C9. (1993) (175)
Inflammasome Activation by Adenylate Cyclase Toxin Directs Th17 Responses and Protection against Bordetella pertussis (2010) (172)
Three Adenovirus E3 Proteins Cooperate to Evade Apoptosis by Tumor Necrosis Factor-related Apoptosis-inducing Ligand Receptor-1 and -2* (2001) (166)
Autoproteolysis of PIDD marks the bifurcation between pro‐death caspase‐2 and pro‐survival NF‐κB pathway (2007) (166)
Perforin and granzymes: crucial effector molecules in cytolytic T lymphocyte and natural killer cell-mediated cytotoxicity. (1995) (165)
The Tumor Necrosis Factor-related Apoptosis-inducing Ligand Receptors TRAIL-R1 and TRAIL-R2 Have Distinct Cross-linking Requirements for Initiation of Apoptosis and Are Non-redundant in JNK Activation* (2000) (161)
NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant (2011) (158)
Peripheral T cells undergoing superantigen-induced apoptosis in vivo express B220 and upregulate Fas and Fas ligand (1996) (156)
The Caspase 8 Inhibitor c-FLIPL Modulates T-Cell Receptor-Induced Proliferation but Not Activation-Induced Cell Death of Lymphocytes (2002) (155)
Neutrophil-derived APRIL concentrated in tumor lesions by proteoglycans correlates with human B-cell lymphoma aggressiveness. (2007) (154)
TWEAK can induce cell death via endogenous TNF and TNF receptor 1 (1999) (154)
Cysteine 230 Is Essential for the Structure and Activity of the Cytotoxic Ligand TRAIL* (2000) (154)
Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9 (1982) (153)
Death receptors in cutaneous biology and disease. (2000) (152)
Activation of a pro‐apoptotic amplification loop through inhibition of NF‐κB‐dependent survival signals by caspase‐mediated inactivation of RIP (2000) (152)
NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8+ T cells (2012) (151)
The apoptosis endonucleases: cleaning up after cell death? (1994) (151)
Membrane attack by complement. (1984) (150)
Polymerization of the ninth component of complement (C9): formation of poly(C9) with a tubular ultrastructure resembling the membrane attack complex of complement. (1982) (149)
Structure of oligosaccharides on Saccharomyces SUC2 invertase secreted by the methylotrophic yeast Pichia pastoris. (1991) (148)
Innate Immunity: Cytoplasmic DNA Sensing by the AIM2 Inflammasome (2009) (147)
Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis (2012) (145)
CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation. (2002) (145)
RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF‐κB and is processed during apoptosis (2002) (145)
Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells (2001) (143)
Granules of cytolytic T‐lymphocytes contain two serine esterases. (1986) (143)
Caspase-2 activation in the absence of PIDDosome formation (2009) (143)
The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes (1993) (141)
NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain. (2003) (141)
NLRP3 suppresses NK cell-mediated responses to carcinogen-induced tumors and metastases. (2012) (139)
The sequence and topology of human complement component C9. (1985) (137)
New insights into the mechanism of IL-1β maturation (2003) (134)
Cell specificity of granzyme gene expression. (1990) (133)
Characterization of two receptors for TRAIL 1 (1997) (132)
Design and synthesis of novel cyclic RGD-containing peptides as highly potent and selective integrin alpha IIb beta 3 antagonists. (1994) (131)
Cellular FLIP (Long Form) Regulates CD8+ T Cell Activation through Caspase-8-Dependent NF-κB Activation1 (2005) (130)
Overexpression of Helicard, a CARD-Containing Helicase Cleaved during Apoptosis, Accelerates DNA Degradation (2002) (130)
DNA fragmentation during apoptosis is caused by frequent single-strand cuts. (1993) (130)
Functional expression of Fas and Fas ligand on human gut lamina propria T lymphocytes. A potential role for the acidic sphingomyelinase pathway in normal immunoregulation. (1996) (129)
Bcl-rambo, a Novel Bcl-2 Homologue That Induces Apoptosis via Its Unique C-terminal Extension* (2001) (128)
Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes. (1994) (127)
Histones trigger sterile inflammation by activating the NLRP3 inflammasome (2013) (126)
Intracellular Trafficking of Interleukin-1 Receptor I Requires Tollip (2006) (126)
Identification of a New Murine Tumor Necrosis Factor Receptor Locus That Contains Two Novel Murine Receptors for Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)* (2003) (125)
Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system (2010) (124)
Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells (2003) (123)
Myelin oligodendrocyte glycoprotein‐induced autoimmune encephalomyelitis is chronic/relapsing in perforin knockout mice, but monophasic in Fas‐ and Fas ligand‐deficient lpr and gld mice (1997) (121)
The death domain motif found in Fas (Apo‐1) and TNF receptor is present in proteins involved in apoptosis and axonal guidance (1995) (121)
Pathogenic Vibrio Activate NLRP3 Inflammasome via Cytotoxins and TLR/Nucleotide-Binding Oligomerization Domain-Mediated NF-κB Signaling (2010) (121)
NLRC5 Deficiency Selectively Impairs MHC Class I- Dependent Lymphocyte Killing by Cytotoxic T Cells (2012) (121)
Murine clusterin: molecular cloning and mRNA localization of a gene associated with epithelial differentiation processes during embryogenesis (1993) (121)
Smac Mimetics and TNFα: A Dangerous Liaison? (2007) (120)
Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis (2012) (119)
Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-κB target genes. (2012) (118)
GAL2 codes for a membrane-bound subunit of the galactose permease in Saccharomyces cerevisiae (1986) (117)
Selective expression of FLIP in malignant melanocytic skin lesions. (2001) (114)
Apoptosis of Fashigh CD4+ Synovial T Cells by Borrelia-reactive Fas-ligandhigh γδ T Cells in Lyme Arthritis (1996) (113)
Interaction of chondroitin sulfate with perforin and granzymes of cytolytic T-cells is dependent on pH. (1990) (112)
The heparin binding domain of S-protein/vitronectin binds to complement components C7, C8, and C9 and perforin from cytolytic T-cells and inhibits their lytic activities. (1988) (112)
The Role of Potassium in Inflammasome Activation by Bacteria* (2010) (110)
Phosphorylcholine acts as a Ca2+-dependent receptor molecule for lymphocyte perforin (1989) (109)
Integrin αIIbβ3 Inhibitor Preserves Microvascular Patency in Experimental Acute Focal Cerebral Ischemia (2000) (108)
Equine Herpesvirus-2 E10 Gene Product, but Not Its Cellular Homologue, Activates NF-κB Transcription Factor and c-Jun N-terminal Kinase* (1999) (108)
The anti‐apoptotic factor Bcl‐2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFF (2004) (106)
Ultrastructure of the membrane attack complex of complement: detection of the tetramolecular C9-polymerizing complex C5b-8. (1982) (105)
TCR-induced NF-κB activation: a crucial role for Carma1, Bcl10 and MALT1 (2003) (105)
BAFF and the regulation of B cell survival. (2003) (104)
Dynamic correlation of apoptosis and immune activation during treatment of HIV infection (1999) (103)
Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes (2013) (102)
Protein-based therapeutic approaches targeting death receptors (2003) (100)
Bcl‐2 protects from oxidative damage and apoptotic cell death without interfering with activation of NF‐κB by TNF (1994) (100)
Apoptosis: Silencing the death receptors (1999) (100)
Fist/Hipk3 (2000) (98)
The resolution of lesions induced by Leishmania major in mice requires a functional Fas (APO‐1, CD 95) pathway of cytotoxicity (1998) (98)
Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes. (1988) (97)
TLR3 and Rig-Like Receptor on Myeloid Dendritic Cells and Rig-Like Receptor on Human NK Cells Are Both Mandatory for Production of IFN-γ in Response to Double-Stranded RNA (2010) (94)
Smac mimetics and TNFalpha: a dangerous liaison? (2007) (94)
APRIL, a new member of the tumor necrosis factor family, modulates death ligand-induced apoptosis (2001) (93)
Sequence and structure of the yeast galactose transporter (1989) (92)
Defective death receptor signaling as a cause of tumor immune escape. (2002) (92)
Inhibition of post-ischemic brain injury by clusterin overexpression (2001) (91)
Complete primary structure and functional characterization of the sixth component of the human complement system. Identification of the C5b-binding domain in complement C6. (1989) (90)
Interaction between a Ca2+-binding protein calreticulin and perforin, a component of the cytotoxic T-cell granules. (1998) (89)
Cytotoxic T lymphocyte mediated cytolysis. (1988) (88)
Direct physical interaction between the Caenorhabditis elegans ‘death proteins’ CED‐3 and CED‐4 (1997) (88)
Anti-apoptotic strategies of lymphotropic viruses. (1998) (87)
HLA class II-mediated death is induced via Fas/Fas ligand interactions in human splenic B lymphocytes. (1997) (86)
Structure of the PRYSPRY‐domain: Implications for autoinflammatory diseases (2006) (85)
Inhibition of Death Receptor Signaling by Flice-Inhibitory Protein as a Mechanism for Immune Escape of Tumors (1999) (84)
Perforin is present only in normal activated Lyt2+ T lymphocytes and not in L3T4+ cells, but the serine protease granzyme A is made by both subsets. (1987) (82)
Ultrastructure of the membrane attack complex of complement. Heterogeneity of the complex caused by different degree of C9 polymerization. (1984) (80)
Elimination of P. berghei liver stages is independent of Fas (CD95/Apo‐I) or perforin‐mediated cytotoxicity (1997) (80)
From inflammasomes to fevers, crystals and hypertension: how basic research explains inflammatory diseases. (2007) (80)
PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling. (2012) (80)
Peptide modification or blocking of CD8, resulting in weak TCR signaling, can activate CTL for Fas- but not perforin-dependent cytotoxicity or cytokine production. (1998) (79)
TGF‐β induces the expression of the FLICE‐inhibitory protein and inhibits Fas‐mediated apoptosis of microglia (2000) (78)
Distribution of deoxyribonuclease I in rat tissues and its correlation to cellular turnover and apoptosis (programmed cell death). (1994) (78)
The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases (2008) (77)
Frequent downregulation of Fas (CD95) expression and function in melanoma (2002) (77)
NLRX1/NOD5 deficiency does not affect MAVS signalling (2011) (77)
The Role of the Inflammasome in Nonmyeloid Cells (2010) (75)
Antibody-independent activation of C1, the first component of complement, by cardiolipin. (1985) (75)
Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytes. (1988) (74)
Localization and molecular modelling of the membrane-inserted domain of the ninth component of human complement and perforin. (1990) (74)
Caspase‐induced inactivation of the anti‐apoptotic TRAF1 during Fas ligand‐mediated apoptosis (2000) (73)
Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis (2008) (72)
Neurons induced to express major histocompatibility complex class I antigen are killed via the perforin and not the Fas (APO‐1/CD95) pathway (1996) (72)
Distinct sites of production and deposition of the putative cell death marker clusterin in the human thymus. (1992) (70)
Characterization of the non-functional Fas ligand of gld mice. (1995) (70)
Fas Ligand-Induced c-Jun Kinase Activation in Lymphoid Cells Requires Extensive Receptor Aggregation But Is Independent of DAXX, and Fas-Mediated Cell Death Does Not Involve DAXX, RIP, or RAIDD1 (2000) (70)
Fas-associated Death Domain Protein (FADD) and Caspase-8 Mediate Up-regulation of c-Fos by Fas Ligand and Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) via a FLICE Inhibitory Protein (FLIP)-regulated Pathway* (2001) (70)
Assembly of macromolecular pores by immune defense systems. (1991) (70)
Fas Ligand (CD95L) Protects Neurons Against Perforin- Mediated T Lymphocyte Cytotoxicity1 (2001) (70)
Comparison of Fas(Apo-1/CD95)- and perforin-mediated cytotoxicity in primary T lymphocytes. (1996) (70)
Identification of granzyme A isolated from cytotoxic T‐lymphocyte‐granules as one of the proteases encoded by CTL‐specific genes (1986) (69)
NLRP3 promotes inflammation‐induced skin cancer but is dispensable for asbestos‐induced mesothelioma (2012) (69)
Overexpression of deoxyribonuclease I (DNase I) transfected into COS-cells: its distribution during apoptotic cell death. (1993) (69)
Intracellular Localization of Keratinocyte Fas Ligand Explains Lack of Cytolytic Activity under Physiological Conditions* (2003) (69)
Circular polymerization of the ninth component of complement. Ring closure of the tubular complex confers resistance to detergent dissociation and to proteolytic degradation. (1982) (68)
Comparative molecular modelling of the Fas-ligand and other members of the TNF family. (1995) (68)
Inhibition of lymphocyte mediated cytotoxicity by perforin antisense oligonucleotides. (1990) (67)
Regulation of Fas Ligand-Induced Apoptosis by TNF1 (2001) (65)
The mycobacterial cord factor adjuvant analogue trehalose-6,6'-dibehenate (TDB) activates the Nlrp3 inflammasome. (2013) (65)
Structure and evolutionary origin of the human granzyme H gene. (1991) (65)
The membrane attack complex of complement: C5b-8 complex as accelerator of C9 polymerization. (1985) (65)
Effect of nephritic factor on C3 and on the terminal pathway of complement in vivo and in vitro. (1986) (64)
Integrin alpha(IIb)beta(3) inhibitor preserves microvascular patency in experimental acute focal cerebral ischemia. (2000) (64)
Danger Signaling through the Inflammasome Acts as a Master Switch between Tolerance and Sensitization1 (2008) (63)
p53-induced protein with a death domain (PIDD) isoforms differentially activate nuclear factor-kappaB and caspase-2 in response to genotoxic stress (2008) (63)
Loss of caspase-8 expression in neuroblastoma is related to malignancy and resistance to TRAIL-induced apoptosis. (2000) (62)
The estrogen-responsive B box protein: a novel enhancer of interleukin-1β secretion (2006) (62)
The inflammasome (2005) (62)
Contribution of TIR domain-containing adapter inducing IFN-beta-mediated IL-18 release to LPS-induced liver injury in mice. (2009) (62)
Interaction of peptides derived from the Fas ligand with the Fyn‐SH3 domain (1995) (61)
Complementary DNA cloning of complement C8 beta and its sequence homology to C9. (1987) (61)
Cleavage of the thrombin receptor: identification of potential activators and inactivators. (1996) (60)
Dimeric, trimeric and tetrameric complexes of immunoglobulin G fix complement. (1980) (60)
Regulation of Fas(Apo‐1/CD95)‐ and perforinmediated lytic pathways of primary cytotoxic T lymphocytes by the protooncogene bcl‐2 (1995) (59)
Appearance of cytolytic granules upon induction of cytolytic activity in CTL‐hybrids. (1985) (59)
Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase‐1 activation in macrophages (2010) (57)
Assembly of subcomponents C1r and C1s of first component of complement: electron microscopic and ultracentrifugal studies. (1980) (56)
Cellular FLIP Long Form Augments Caspase Activity and Death of T Cells through Heterodimerization with and Activation of Caspase-81 (2005) (55)
Demonstration of granzyme A and perforin messenger RNA in the synovium of patients with rheumatoid arthritis. (1995) (55)
Perforin-induced pore formation (1991) (55)
Circular polymerization of the membranolytic ninth component of complement. Dependence on metal ions. (1984) (54)
Fas ligand expression is restricted to nonlymphoid thymic components in situ. (1997) (53)
Molecular weight of poly(C9). 12 to 18 C9 molecules form the transmembrane channel of complement. (1984) (53)
Studies on the interaction between TWEAK and the death receptor WSL‐1/TRAMP (DR3) (2000) (53)
cDNA cloning of granzyme C, a granule-associated serine protease of cytolytic T lymphocytes. (1988) (52)
Cleavage of caspase family members by granzyme B: a comparative study in vitro (1997) (52)
Granzymes: a family of serine proteases in granules of cytolytic T lymphocytes. (1989) (51)
Constitutive Fas ligand expression in several non-lymphoid mouse tissues: implications for immune-protection and cell turnover. (1996) (51)
Development of improved soluble inhibitors of FasL and CD40L based on oligomerized receptors. (2000) (51)
Clusterin in renal tissue: preferential localization with the terminal complement complex and immunoglobulin deposits in glomeruli (1992) (51)
NALP3 is not necessary for early protection against experimental tuberculosis. (2010) (50)
Propidium iodide staining correlates with the extent of DNA degradation in isolated nuclei. (1992) (50)
Isolation and complete structure of the lymphocyte serine protease granzyme G, a novel member of the granzyme multigene family in murine cytolytic T lymphocytes. Evolutionary origin of lymphocyte proteases. (1989) (50)
IgG subclass switch capacity is low in switched and in IgM‐only, but high in IgD+IgM+, post‐germinal center (CD27+) human B cells (2001) (50)
New insights into the mechanism of IL-1beta maturation. (2003) (50)
Inhibition of the lytic activity of perforin (cytolysin) and of late complement components by proteoglycans. (1987) (50)
Cutting Edge: Cyclic Polypeptide and Aminoglycoside Antibiotics Trigger IL-1β Secretion by Activating the NLRP3 Inflammasome (2011) (49)
Antiviral Antibodies Target Adenovirus to Phagolysosomes and Amplify the Innate Immune Response1 (2009) (49)
Domain structure of the endothelial cell receptor thrombomodulin as deduced from modulation of its anticoagulant functions. Evidence for a glycosaminoglycan-dependent secondary binding site for thrombin. (1990) (49)
Intracellular pattern-recognition receptors. (2008) (48)
Fas and Fas ligand expression in tumor cells and in vascular smooth‐muscle cells of colonic and renal carcinomas (1999) (48)
IL-4 Potentiates Activated T Cell Apoptosis Via an IL-2-Dependent Mechanism 1 (2003) (48)
IRAK2 takes its place in TLR signaling (2008) (48)
Purification, characterization and reassembly of the bacteriophage T4D tail sheath protein P18. (1979) (46)
Expression of B220 on activated T cell blasts precedes apoptosis. (1997) (46)
Lack of DNA degradation in target cells lysed by granules derived from cytolytic T lymphocytes. (1988) (45)
Antibody-independent activation of the complement system by mitochondria is mediated by cardiolipin. (1988) (45)
Subunit interactions of tryptophan synthase from Escherichia coli as revealed by binding studies with pyridoxal phosphate analogues. (1980) (45)
Functional size of complement and perforin pores compared by confocal laser scanning microscopy and fluorescence microphotolysis. (1991) (45)
Manipulation of cellular interactions with biomaterials toward a therapeutic outcome: A perspective (1994) (45)
Interaction of Fas(Apo‐1/CD95) with proteins implicated in the ubiquitination pathway (1997) (44)
Ultrastructural distribution of the death-domain-containing MyD88 protein in HeLa cells. (1998) (44)
Inflammatory Role of ASC in Antigen-Induced Arthritis Is Independent of Caspase-1, NALP-3, and IPAF1 (2009) (44)
Quantitation of vitronectin and clusterin. Pitfalls and solutions in enzyme immunoassays for adhesive proteins. (1993) (44)
Human megakaryocytes express clusterin and package it without apolipoprotein A-1 into alpha-granules. (1993) (44)
TCR-induced NF-kappaB activation: a crucial role for Carma1, Bcl10 and MALT1. (2003) (44)
Bcl-2 does not inhibit cell death induced by the physiological Fas ligand: implications for the existence of type I and type II cells (2000) (43)
Human clusterin (CLI) maps to 8p21 in proximity to the lipoprotein lipase (LPL) gene. (1993) (43)
The serine protease granzyme A does not induce platelet aggregation but inhibits responses triggered by thrombin. (1996) (43)
Down‐modulation of CD4+ T helper type 2 and type 0 cells by T helper type 1 cells via Fas/Fasligand interaction (1995) (42)
Identification of a basic surface area of the FADD death effector domain critical for apoptotic signaling (2002) (42)
Resistance of CTL to perforin-mediated lysis. Evidence for a lymphocyte membrane protein interacting with perforin. (1994) (42)
Thyroiditis and hepatitis: Fas on the road to disease (1997) (41)
Cellular FLIP Long Form-Transgenic Mice Manifest a Th2 Cytokine Bias and Enhanced Allergic Airway Inflammation 1 (2004) (41)
Metabolic gene expression changes in astrocytes in Multiple Sclerosis cerebral cortex are indicative of immune-mediated signaling (2015) (40)
Appearance of granule-associated molecules during activation of cytolytic T-lymphocyte precursors by defined stimuli. (1988) (39)
About the involvement of deoxyribonuclease I in apoptosis. (1994) (39)
Activation of the IL -1 β-processing inflammasome is involved in contact hypersensitivity. Commentery (2007) (39)
Defective plasma membrane assembly in yeast secretory mutants (1984) (38)
Herpesvirus Saimiri Transforms Human T-Cell Clones to Stable Growth without Inducing Resistance to Apoptosis (1998) (37)
Dissection of functional domains in Bcl-2 alpha by site-directed mutagenesis. (1994) (37)
CD4+ T cells reactivated with superantigen are both more sensitive to FasL-mediated killing and express a higher level of FasL. (1997) (37)
The dissociation properties of native C1. (1982) (37)
Immunohistochemical localization of granzyme B antigen in cytotoxic cells in human tissues. (1991) (35)
Inhibition of the lytic activity of perforin by lipoproteins. (1986) (35)
Structural and functional characterization of complement C8 gamma, a member of the lipocalin protein family. (1991) (35)
Transients of perforin pore formation observed by fluorescence microscopic single channel recording. (1990) (35)
Reassembly of the bacteriophage T4 tail from the core-baseplate and the monomeric sheath protein P18: a co-operative association process. (1979) (35)
The TRAF3-binding site of human molluscipox virus FLIP molecule MC159 is critical for its capacity to inhibit Fas-induced apoptosis (2006) (34)
Sequence similarity of phospholipase A2 activating protein and the G protein beta-subunits: a new concept of effector protein activation in signal transduction? (1993) (33)
Expression of B220 on activated T cell blasts precedes apoptosis (1998) (32)
Expression level of c-FLIP versus Fas determines susceptibility to Fas ligand-induced cell death in murine thymoma EL-4 cells. (2002) (32)
Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes (2013) (32)
DEteCTINg fungal pathogens (2007) (32)
Genomic organisation and expression of mouse deoxyribonuclease I. (1995) (32)
Proteoglycans in secretory granules of NK cells. (1986) (31)
Antigen‐independent binding of IgG dimers to C1 q as studied by sedimentation equilibrium, complement fixation and electron microscopy (1980) (31)
Ectopic expression of the serine protease inhibitor PI9 modulates death receptor-mediated apoptosis (2007) (30)
Membranolysis by the ninth component of human complement. (1981) (30)
Inhibition of lymphocyte protease granzyme A by antithrombin III. (1988) (30)
Angiotensin II-forming heart chymase is a mast-cell-specific enzyme. (1991) (29)
TNF-α–dependent loss of IKKβ-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis (2011) (29)
Functional characterisation of serum DNase I in MRL-lpr/lpr mice. (1992) (29)
Invertase gene (SUC2) of Saccharomyces cerevisiae as a dominant marker for transformation of Pichia pastoris. (1987) (29)
Equine Herpesvirus Protein E10 Induces Membrane Recruitment and Phosphorylation of Its Cellular Homologue, Bcl-10 (2001) (28)
Antigenic crossreactivity of the alpha subunit of complement component C8 with the cysteine-rich domain shared by complement component C9 and low density lipoprotein receptor. (1986) (27)
Occurrence of an incomplete C8 molecule in homozygous C8 deficiency in man (1981) (27)
Antigen‐independent activation of the first component of complement C1 by chemically crosslinked rabbit IgG‐oligomers (1980) (27)
Genomic organization and subchromosomal in situ localization of the murine granzyme F, a serine protease expressed in CD8+ T cells. (1991) (26)
Absence of homologous restriction factor does not affect CTL‐mediated cytolysis (1989) (26)
Simian immunodeficiency virus (SIVsm) infection of cynomolgus monkeys: effects on follicular dendritic cells in lymphoid tissue. (1992) (26)
[5] Granzyme B (1994) (26)
Apoptosis: Searching for FLASH domains (1999) (26)
Granzyme B. (1994) (25)
Fas-mediated cell death in toxic epidermal necrolysis and graft-versus-host disease: potential for therapeutic inhibition. (2000) (25)
Cells with defective p53-p21-pRb pathway are susceptible to apoptosis induced by p84N5 via caspase-6. (2007) (25)
The membrane attack complex of complement: lipid insertion of tubular and nontubular polymerized C9. (1985) (25)
Selective alpha IIb beta 3 receptor blockage with peptide TP9201 prevents platelet uptake on Dacron vascular grafts without significant effect on bleeding time. (1994) (24)
The role of cytoplasmic granule components in cytolytic lymphocyte-mediated cytolysis. (1987) (24)
Contribution of TNF/TNF receptor and of Fas ligand to toxicity in murine models of endotoxemia and bacterial peritonitis. (1995) (23)
Structural homology of human complement component C8 gamma and plasma protein HC: identity of the cysteine bond pattern. (1987) (23)
Human perforin (PRF1) maps to 10q22, a region that is syntenic with mouse chromosome 10. (1992) (23)
Dissociation of C1 and concentration dependence of its activation kinetics. (1982) (23)
The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade (2011) (22)
Macrophage precursor cells produce perforin and perform Yac‐1 lytic activity in response to stimulation with interleukin‐2 (1994) (22)
The combination of chemotherapy and intraperitoneal MegaFas Ligand improves treatment of ovarian carcinoma. (2007) (21)
Two distinct subfractions in isolated Saccharomyces cerevisiae plasma membranes (1983) (21)
IRF‐3 partners Bax in a viral‐induced dance macabre (2010) (20)
Kinetics of activation of the first component of complement (C1) by IgG oligomers. (1982) (20)
PIDD orchestrates translesion DNA synthesis in response to UV irradiation (2011) (20)
Pathways for Cytolysis (1995) (20)
Cytotoxic T cells: more weapons for new targets? (1996) (20)
Kinetics of cooperative ligand binding to the apo beta 2 subunit of tryptophan synthase and its modulation by the alp ha subunit. (1980) (19)
Ubiquitination of the Epstein–Barr virus-encoded latent membrane protein 1 depends on the integrity of the TRAF binding site (2003) (19)
Preparation and characterization of chemically defined oligomers of rabbit immunoglobulin G molecules for the complement binding studies. (1980) (18)
Effects of purified perforin and granzyme A from cytotoxic T lymphocytes on guinea pig ventricular myocytes. (1994) (18)
Involvement of the N‐methyl‐D‐aspartate receptor in neuronal cell death induced by cytotoxic T cell‐derived secretory granules (1999) (17)
Heterologous gene expression in methylotrophic yeast. (1991) (17)
Holozyme A: One of the serine proteases of Holothuria polii coelomocytes (1990) (17)
Clusterin gene expression in the rat thymus is not modulated by dexamethasone treatment. (1994) (16)
Murine Thy-1+ dendritic epidermal T cell lines express granule-associated perforin and a family of granzyme molecules. (1992) (16)
Dysfunctional C8β Chain in Patients with C8 Deficiency (1986) (16)
Fas-dependent tissue turnover is implicated in tumor cell clearance (2000) (16)
Regulation of PIDD auto-proteolysis and activity by the molecular chaperone Hsp90 (2011) (16)
Antibody-independent activation of C1. II. Evidence for two classes of nonimmune activators of the classical pathway of complement. (1987) (16)
Membrane attack complex (MAC) deposits in skin are not always accompanied by S-protein and clusterin. (1992) (16)
Secretion of heterologous proteins from the methylotrophic yeast, Pichia pastoris (1988) (15)
Overexpression of Helicard, a CARD-Containing Helicase Cleaved during Apoptosis, Accelerates DNA Degradation (2002) (15)
Increased p34cdc2-dependent kinase activity during apoptosis: a possible activation mechanism of DNase I leading to DNA breakdown. (1996) (14)
Thogoto Virus Infection Induces Sustained Type I Interferon Responses That Depend on RIG-I-Like Helicase Signaling of Conventional Dendritic Cells (2010) (14)
Altered Thymic Selection by Over-Expressing Cellular FLICE Inhibitory Protein in T Cells Causes Lupus-like Syndrome in BALB/c but not C57BL/6 Strain (2009) (14)
Expression of Fas (APO-1/CD95) and Fas ligand (FasL) in human neuroblastoma. (2001) (14)
Mutations in the putative lipid-interaction domain of complement C9 result in defective secretion of the functional protein. (1993) (14)
A unique epitope exposed in native complement component C9 and hidden in the terminal SC5b-9 complex enables selective detection and quantification of non-activated C9. (1987) (14)
Expression of the CTL-associated protein TIA-1 during murine embryogenesis. (1996) (13)
NLRX1: friend or foe? (2008) (12)
Biological activities of granzyme K are conserved in the mouse and account for residual Z‐Lys‐SBzl activity in granzyme A‐deficient mice (1999) (12)
Extra-long bacteriophage T4 tails produced under in vitro conditions. (1977) (12)
The Methylotrophic Yeast Pichia Pastoris as a Host for Heterologous Protein Production (1987) (12)
David Artis and Jürg Tschopp (2010) (12)
Inhibition of Thrombosis by a Selective Fibrinogen Receptor Antagonist without Effect on Bleeding Time (1994) (12)
No histological evidence for cytotoxic T cells in destruction of lymph-node follicle centres after HIV infection? (1991) (12)
Debate: the mechanism of lymphocyte-mediated killing. Perforin-induced pore formation. (1991) (11)
Corrigendum to: Carma1, a CARD‐containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF‐κB activation (FEBS 24842) (2001) (10)
Renin-Dependent Hypertension in Mice Requires the NLRP3- (2013) (10)
[26] Therapeutic application of matrix biology (1994) (9)
Activation-dependent epitopes in the terminal complement pathway. (1989) (9)
Complete Primary Structure and Functional Characterization of the Sixth Component of the Human Complement System (2001) (8)
Complement activation by pulsed tunable dye laser in normal skin and hemangioma. (1990) (8)
Cytolytic T cells keep their secrets (1993) (7)
Fas Ligand ( CD 95 L ) Protects Neurons Against Perforin-Mediated T Lymphocyte Cytotoxicity 1 (2001) (7)
Granzyme A — Immunoreactive cells in synovial fluid in reactive and rheumatoid arthritis (1992) (6)
Involvement of granule proteins in T-cell-mediated cytolysis. (1990) (6)
Increased hemolytic activity of the trypsin-cleaved ninth component of complement. (1986) (6)
96 A Crucial Function of SGT1 and HSP90 in Inflammasome Activity Links Mammalian and Plant Innate Immune Responses (2007) (6)
IMPACT OF NLRP3 INFLAMMASOME ON THE DEVELOPMENT OF HYPERTENSION AND RENAL AND CARDIAC HYPERTROPHY IN 2K1C AND DOCA/SALT MICE (2012) (5)
A novel potent Fas agonist for selective depletion of tumor cells in hematopoietic transplants (2011) (5)
PL-10 Induction of innate immune responses through Nalp3 inflammasome sensing of asbestos and silica (2008) (5)
Perforin and its role in T lymphocyte-mediated cytolysis (1992) (5)
Identification of a Human C5 β‐Chain Epitope Exposed in the Native Complement Component but Concealed in the SC5b‐9 Complex (1988) (5)
Cutting Edge Cutting Edge : Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP 3 Inflammasome (2008) (4)
New knowledge about T-cell cytotoxicity. (1997) (4)
3.8 Relationship between vertebrate channel-forming proteins and invertebrate hemolysins (1989) (4)
CTL-mediated cytolysis: perforin and alternative pathways? (1989) (4)
Kinetics of the cooperative association of T4 tail sheath protein P18 to polysheaths. (1980) (4)
Melanoma cells express Fas ligand: Implications for tumor immune escape (1997) (4)
Structure and Possible Functions of Lymphocyte Granzymes (1993) (4)
Activation of the NALP 3 Inflammasome Inflammatory Dendritic Cells through Cutting Edge : Alum Adjuvant Stimulates (2008) (3)
Integrin a IIb b 3 Inhibitor Preserves Microvascular Patency in Experimental Acute Focal Cerebral Ischemia (2000) (3)
Dysfunctional C8 beta chain in patients with C8 deficiency. (1986) (3)
Apoptosis of Fas high CD4 1 Synovial T Cells by Borrelia- reactive Fas-ligand high gd T Cells in (1996) (2)
Antigenic crossreactivity of the a subunit of complement component C8 with the cysteine-rich domain shared by complement component C9 and low density lipoprotein receptor (2)
C5b-8 mediated and spontaneous polymerization of C9: Formation of C9 polymers with ultrastructural resemblance of the membrane attack complex (MAC) (1982) (2)
Design & synthesis of novel cyclic rgd peptides as highly potent & selective GPIIb/IIIa antagonists (1994) (2)
Viruses under the control of RIP kinases (2010) (2)
Therapeutic application of matrix biology. (1994) (2)
Apoptosis induced by Fas (1999) (1)
Tissues Suggesting a Site-specific Role in the Inflammatory Response Inflammasome Components NALP 1 and 3 Show Distinct but Separate Expression Profiles in Human (2013) (1)
INTERACTIONS OF TNF AND TNF RECEPTOR FAMILY MEMBERS IN THE MOUSE AND HUMAN. of the superfamily (2006) (1)
S53 Nanoparticles cause pulmonary inflammation through IL-1α and partial activation of the NLRP3 inflammasome (2010) (1)
Via an IL-2-Dependent Mechanism IL-4 Potentiates Activated T Cell Apoptosis (2003) (1)
Cellular Immunity And Pathological Alterations In Ms Grey Matter (2009) (1)
Detection of Serine Esterase Granzyme B as Indicator of Cytotoxic Cells in Lymphoid Follicles of Man and Cynomolgus Monkeys after HIV-1 /SIV Infection (1992) (1)
Human Cytomegalovirus Superfamily Member in Virulent Strains of Cutting Edge : A Novel Viral TNF Receptor (1999) (1)
Production Perforin-Dependent Cytotoxicity or Cytokine Activate CTL for Fas-But Not Resulting in Weak TCR Signaling (1998) (1)
Reveals a Predisposition to B Cell Lymphoma Transgenic Mice against Autoimmunity and TNF Deficiency Fails to Protect BAFF (2003) (1)
177 Critical Role of TNFR-Associated Death Domain (TRADD) in the Toll-Like Receptor (TLR)-Independent Antiviral Response (2007) (1)
687 Loss of the NOD2-Related Molecule NLRP3 Results in Broad Changes in the Innate Immune Response and Intestinal Microbiota Resulting in an Increased Susceptibility to Intestinal Inflammation (2010) (1)
Characterization of human clusterin as a novel secreted stress protein induced by heat shock and oxidative stress in A431 cells (1994) (1)
Transients of perforin pore formation observed by fluorescence microscopic single channel recording (1990) (1)
Cellular flip (flice-inhibitory protein), a specific inhibitor of receptor-mediated cell death, is upregulated during cutaneous melanoma development (1998) (0)
Allergic Airway Inflammation Manifest a Th2 Cytokine Bias and Enhanced Cellular FLIP Long Form-Transgenic Mice (2004) (0)
W1785 Loss of NLRP3 Signaling Results in Altered Dendritic Cells (DC) Population and Impaired Induction of Regulatory T Cells (Treg): Implications for Intestinal Inflammation (2010) (0)
An fMRI Investigation of Emotional Engagement in Moral Judgment (2007) (0)
862 The NALP-3 Inflammasome Plays a Critical Innate Immune Protective Role in Intestinal Homeostasis and Inflammation (2009) (0)
Membranolysis by isolated C9 in the absence of other complement proteins (1982) (0)
Inhibitors of caspase-8 for immunosuppression. (2000) (0)
Use of a caspase-inhibitor for the inhibition of proliferation of cells and using one or more caspase inhibitor / s for the treatment of diseases based on lymphocyte hyperproliferation or for suppression of an immune response by lymphocytes (1999) (0)
Innate Immunity (2003) (0)
Searching for FLASH domains. Authors' reply (1999) (0)
Th17 (PP-014) (2010) (0)
Double-Stranded RNA in Response to g Production of IFN-Human NK Cells Are Both Mandatory for Dendritic Cells and Rig-Like Receptor on TLR3 and Rig-Like Receptor on Myeloid (2010) (0)
Characterization of NK 1 . 1 + CD 8 T cells in allogeneic hematopoietic cell transplantation recipients (2010) (0)
NMR structure of the NALP1 Pyrin domain (PYD) (2003) (0)
Basic calcium phosphate crystals induce IL-1B secretion in vitro through activation of the Nalp3 inflammasome (2010) (0)
Immune Response Phagolysosomes and Amplify the Innate Antiviral Antibodies Target Adenovirus to (2009) (0)
A role for BAFF in the development of Sjogren's syndrome through recruitment of B cells with a marginal zone-like phenotype (2001) (0)
and Sensitization Acts as a Master Switch between Tolerance Danger Signaling through the Inflammasome (2008) (0)
Oligomeric Death Domain complex (2007) (0)
Inhibitionof death receptor signalsbycellular FLIP (1997) (0)
Polymerization of the ninth compo Formation of poly(C9) with a tubul the membrane attack complex of c, (protein-protein interactions/protein-phospholipid interactions/prot (2016) (0)
BAFF T Cell Costimulation by the TNF Ligand Tschopp (2001) (0)
BAFF, inhibitors and their use in modulating the B-cell response (2000) (0)
ROLE OF THE NALP3 INFLAMMASOME IN THE DEVELOPMENT OF TWO-KIDNEY, ONE CLIP HYPERTENSION IN MICE: PP.24.485 (2010) (0)
Table of Contents (1990) (0)
Regulating Region of heterologous gene expression in yeast (1985) (0)
Faculty Opinions recommendation of 5'-Triphosphate RNA is the ligand for RIG-I. (2006) (0)
Use of ligands of death receptors or RIP for triggering the caspase-independent cell death, and compounds for inhibition of the caspase-independent cell death (2000) (0)
Manufacture of hepatitis B surface antigen (HBsAg) by means of yeast. (1986) (0)
Lymphoid follicles in cynomolgus monkeys after infection with simian immunodeficiency virus. (1993) (0)
A regulatory region from a heterologous gene for expression in yeast (1985) (0)
Fusion constructs containing active portions of the TNF ligand (2002) (0)
Regulation of Fas Ligand-Induced Apoptosis (2001) (0)
Advances in Brief Loss of Caspase-8 Expression in Highly Malignant Human Neuroblastoma Cells Correlates with Resistance to Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis 1 (2000) (0)
PneumoniaContributes to Host Defense in Pneumococcal Activated by Pneumolysin Variants and The NLRP3 Inflammasome Is Differentially (2011) (0)
Abstract A14: Invalidation of the inflammasome within breast tumor microenvironment impairs tumor growth (2011) (0)
Fas expression and function in human melanocytes, nevus cells and melanoma cell lines: Loss of expression and/or function in 7 of 13 melanoma cell lines (1998) (0)
Cytotoxic mechanisms: cytolytic T cells keep their secrets. (1993) (0)
NLRC5 deficiency impairs MHC class I-dependent lymphocyte killing by cytotoxic T cells (2012) (0)
Table of Contents (1990) (0)
Title : Smac mimetics and TNFalpha : a dangerous liaison ? (0)
Extrinsic Pathway for Apoptosis (2004) (0)
Caspase-8Heterodimerization with and Activation of Activity and Death of T Cells through Cellular FLIP Long Form Augments Caspase (2005) (0)
The gene encoding alcohol oxidase (1993) (0)
DEATH RECEPTORS APOPTOSIS AND CANCER (1999) (0)
Imagerie par resonance magnetique utilisee detecter un thrombus (1997) (0)
Role and function of the apoptosis-regulator PIDD (2007) (0)
Baff, inhibitors and their use in modulating the response of cells b. (2000) (0)
Flip-flip gene and protein (1997) (0)
Use of FasL or FasL transfected CD4 + · · / FasL · - · / TH1-cell lines or FasL in combination with one or more cytokine (s) for the control of Th1 / Th2 diseases (1996) (0)
Activity under Physiological Conditions Fas Ligand Explains Lack of Cytolytic Intracellular Localization of Keratinocyte DEVELOPMENTAL BIOLOGY: MOLECULAR BASIS OF CELL AND (2014) (0)
Domain-Mediated NF-TLR / Nucleotide-Binding Oligomerization Inflammasome via Cytotoxins and Activate NLRP 3 Vibrio Pathogenic (2010) (0)
Octacalcium phosphate (OCP) crystals induce IL-1A and IL-1B dependent inflammation in mice (2010) (0)
This information is current as Irradiation Chemotherapeutic Drugs , and Gamma Receptors But Not by Perforin / Granzyme B , FLIP Prevents Apoptosis Induced by Death (1998) (0)
Human Splenic B Lymphocytes Mediated Death Is Induced Via Fas/Fas Ligand Interactions in - (2013) (0)
Regulation of IL-1 receptor- and TLR-induced NF-κB activation by alternative splicing of MyD88 (2003) (0)
Di-or oligomer of a di-, tri-, tetra- or pentámetro of recombinant fusion proteins. (2000) (0)
Is Fas ligand (CD95L) expression by astrocytoma cells a major mechanism of inactivation of tumour infiltrating lymphocytes (1997) (0)
Cytolysis inhibitor (ZLI), a blood plasma protein, this DNA sequence encoding, as well as a plasmid, a host organism and a method for obtaining this protein (1989) (0)
Regulatory region for the expression of heterologous genes in yeast. (1985) (0)
Method and compound for the treatment of thrombosis (1991) (0)
1016 Inflammasome Activation is a Critical Signaling Pathway in Clostridium difficile Toxin-Induced Intestinal Injury Which Requires Conservation of Specific Toxin Processing Events, Toxin Domains and Downstream Signaling (2010) (0)
NLRC4 inflammasomes in dendritic cells evoke non-cognate effector function by memory CD8 T cells that improve immunity to Salmonella typhimurium (158.1) (2011) (0)
The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia1 (2011) (0)
Gene (ii) encoding new polypeptide (1995) (0)
Procede et composition de traitement de la thrombose (1991) (0)
Assembly of subcompohents CIr and Cls of first component of complement : Electron microscopic and ultracentrifugal studies ( hydrodynamic shape / domain structure (0)
Cytotoxic T-lymphocyte serine proteases: Substrate and inhibitor studies with granzymes A and B, and human Q31 chymase (1992) (0)
Inflammasome (WS-078) Chairpersons: Shun'ichiro Taniguchi, Takashi Suda (2010) (0)
NOVEL ANTICANCER THERAPEUTICS BASED ON MODULATION OF APOPTOSISTHROUGH DEPENDENCE RECEPTORS (HERMIONE) (2005) (0)
Differenzial Activation of the NLRP3 Inflammasome by Pneumolysin Variants and Role of NLRP3 in Pneumococcal Pneumonia (2011) (0)
87 Anti-toll-like receptor 4 (TLR4) antibodies protect from lethal endotoxemia but not from gram-negative septic shock (2006) (0)
TDB) activates the Nlrp3 inflammasome (2012) (0)
HBV-HCV Coinfection: Insights from a Novel Model System (2008) (0)
Innate Immunity 1 (Innate receptors) (SY1-1) Chairpersons: Shizuo Akira, Ruslan Medzhitov (2010) (0)
Bi- or oligomer of a di-, tri-, or Quattro pentamer of recombinant fusion proteins (1999) (0)
Granzyme A Is an Interleukin 13-converting E n z y m e By (2003) (0)

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