Jürgen Brosius | Academic Influence

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Jürgen Brosius

Biology

#4340

World Rank

#6483

Historical Rank

Molecular Biology

#885

World Rank

#908

Historical Rank

biology Degrees

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Biology

Jürgen Brosius's Degrees

PhD Molecular Biology University of Cologne

Why Is Jürgen Brosius Influential?

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According to Wikipedia, Jürgen Brosius in Saarbrücken Biography Early life and education Brosius studied chemistry and pharmacy at the Goethe University of Frankfurt and in 1974 graduated and completed the Staatsexamen in Pharmacy. Subsequently, he pursued his Ph.D. work in biochemistry and molecular biology at the Max Planck Institute for Molecular Genetics in Berlin Dahlem in which Heinz-Günter Wittmann was department head. While determining the primary structures of several E. coli ribosomal proteins, he developed manual micro-methods for isolating peptides using two-dimensional separation on cellulose thin layer plates followed by dansyl-Edman degradation. This reduced the required protein material by one to two orders of magnitude towards the 100 nanomole range. This method was shortly thereafter superseded by automated protein sequencing operating in the low picomole range.

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Jürgen Brosius's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Complete nucleotide sequence of a 16S ribosomal RNA gene from Escherichia coli. (1978) (2252)
Gene organization and primary structure of a ribosomal RNA operon from Escherichia coli. (1981) (1656)
Vectors bearing a hybrid trp-lac promoter useful for regulated expression of cloned genes in Escherichia coli. (1983) (700)
Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization. (2000) (585)
Construction and fine mapping of recombinant plasmids containing the rrnB ribosomal RNA operon of E. coli. (1981) (444)
Regulation of ribosomal RNA promoters with a synthetic lac operator. (1984) (415)
Plasmid vectors for the selection of promoters. (1984) (398)
RNAs from all categories generate retrosequences that may be exapted as novel genes or regulatory elements. (1999) (371)
Identification of 86 candidates for small non-messenger RNAs from the archaeon Archaeoglobus fulgidus (2002) (362)
"ATG vectors' for regulated high-level expression of cloned genes in Escherichia coli. (1985) (346)
Retroposons--seeds of evolution. (1991) (344)
RNomics: an experimental approach that identifies 201 candidates for novel, small, non‐messenger RNAs in mouse (2001) (334)
Secondary structure model for bacterial 16S ribosomal RNA: phylogenetic, enzymatic and chemical evidence. (1980) (319)
Secondary structure model for 23S ribosomal RNA. (1981) (315)
On "genomenclature": a comprehensive (and respectful) taxonomy for pseudogenes and other "junk DNA". (1992) (307)
Complete nucleotide sequence of a 23S ribosomal RNA gene from Escherichia coli. (1980) (286)
Retroposed Elements as Archives for the Evolutionary History of Placental Mammals (2006) (272)
Spacing of the -10 and -35 regions in the tac promoter. Effect on its in vivo activity. (1985) (250)
Dendritic location of neural BC1 RNA. (1991) (225)
Binding of L7Ae protein to the K-turn of archaeal snoRNAs: a shared RNA binding motif for C/D and H/ACA box snoRNAs in Archaea. (2003) (220)
Evolutionary history of 7SL RNA-derived SINEs in Supraprimates. (2007) (220)
Translational Machinery in Dendrites of Hippocampal Neurons in Culture (1996) (219)
Primary structure, neural-specific expression, and dendritic location of human BC200 RNA (1993) (213)
Expression of neural BC200 RNA in human tumours (1997) (193)
Mesozoic retroposons reveal parrots as the closest living relatives of passerine birds (2011) (182)
Structural relationship of human interferon alpha genes and pseudogenes. (1985) (180)
Tracking Marsupial Evolution Using Archaic Genomic Retroposon Insertions (2010) (174)
Deletion of the MBII-85 snoRNA Gene Cluster in Mice Results in Postnatal Growth Retardation (2007) (169)
The Contribution of RNAs and Retroposition to Evolutionary Novelties (2003) (163)
Multiple molecular evidences for a living mammalian fossil (2007) (157)
Superpolylinkers in cloning and expression vectors. (1989) (155)
Precise location of two promoters for the beta-lactamase gene of pBR322. S1 mapping of ribonucleic acid isolated from Escherichia coli or synthesized in vitro. (1982) (154)
Toxicity of an overproduced foreign gene product in Escherichia coli and its use in plasmid vectors for the selection of transcription terminators. (1984) (153)
Poly(A)-binding protein is associated with neuronal BC1 and BC200 ribonucleoprotein particles. (2002) (150)
RNomics: identification and function of small, non-messenger RNAs. (2002) (144)
Genetic variation in the human insulin gene. (1980) (141)
Experimental RNomics Identification of 140 Candidates for Small Non-Messenger RNAs in the Plant Arabidopsis thaliana (2002) (140)
BC200 RNA: a neural RNA polymerase III product encoded by a monomeric Alu element. (1993) (139)
Genomes were forged by massive bombardments with retroelements and retrosequences (2004) (138)
RNomics in Archaea reveals a further link between splicing of archaeal introns and rRNA processing. (2002) (135)
Characterization in vitro of the effect of spacer length on the activity of Escherichia coli RNA polymerase at the TAC promoter. (1985) (135)
Alu-SINE exonization: en route to protein-coding function. (2005) (135)
Rodent evolution: back to the root. (2010) (133)
Waste not, want not--transcript excess in multicellular eukaryotes. (2005) (131)
rII cistrons of bacteriophage T4. DNA sequence around the intercistronic divide and positions of genetic landmarks. (1981) (129)
Exonization of transposed elements: A challenge and opportunity for evolution. (2011) (126)
Inhibitory effect of naked neural BC1 RNA or BC200 RNA on eukaryotic in vitro translation systems is reversed by poly(A)-binding protein (PABP). (2005) (124)
Rodent BC1 RNA gene as a master gene for ID element amplification. (1994) (123)
Neural BC1 RNA: cDNA clones reveal nonrepetitive sequence content. (1987) (123)
Identification of differentially expressed small non-protein-coding RNAs in Staphylococcus aureus displaying both the normal and the small-colony variant phenotype (2010) (116)
Identification of a site on 23S ribosomal RNA located at the peptidyl transferase center. (1984) (114)
Retrocopy contributions to the evolution of the human genome (2008) (112)
Neural BC1 RNA as an evolutionary marker: guinea pig remains a rodent. (1993) (101)
Putative diazepam binding inhibitor peptide: cDNA clones from rat. (1986) (101)
RNomics in Drosophila melanogaster: identification of 66 candidates for novel non-messenger RNAs (2003) (98)
Application of housekeeping npcRNAs for quantitative expression analysis of human transcriptome by real-time PCR. (2010) (97)
Activity-dependent Regulation of Dendritic BC1 RNA in Hippocampal Neurons in Culture (1998) (96)
Functional persistence of exonized mammalian-wide interspersed repeat elements (MIRs). (2007) (95)
Mosaic retroposon insertion patterns in placental mammals. (2009) (91)
Evolution of small nucleolar RNAs in nematodes (2006) (89)
Waves of genomic hitchhikers shed light on the evolution of gamebirds (Aves: Galliformes) (2007) (87)
Retroposed elements and their flanking regions resolve the evolutionary history of xenarthran mammals (armadillos, anteaters, and sloths). (2007) (85)
Clathrin light chains LCA and LCB are similar, polymorphic, and share repeated heptad motifs. (1987) (83)
Diazepam binding inhibitor gene expression: location in brain and peripheral tissues of rat. (1988) (83)
Clathrin heavy chain: molecular cloning and complete primary structure. (1987) (80)
Neuronal BC1 RNA structure: evolutionary conversion of a tRNA(Ala) domain into an extended stem-loop structure. (2001) (78)
Retroposed SNOfall--a mammalian-wide comparison of platypus snoRNAs. (2008) (71)
From "junk" to gene: curriculum vitae of a primate receptor isoform gene. (2004) (70)
The primary structure of protein L16 located at the peptidyltransferase center of Escherichia coli ribosomes (1976) (67)
Exploring Massive Incomplete Lineage Sorting in Arctoids (Laurasiatheria, Carnivora). (2015) (66)
Genomes were forged by massive bombardments with retroelements and retrosequences. (1999) (63)
BC1 RNA: transcriptional analysis of a neural cell-specific RNA polymerase III transcript (1995) (62)
Spatial codes in dendritic BC1 RNA (2006) (61)
Neuronal Untranslated BC1 RNA: Targeted Gene Elimination in Mice (2003) (61)
The buccalin-related neuropeptides: isolation and characterization of an Aplysia cDNA clone encoding a family of peptide cotransmitters (1993) (60)
The genome of a Mesozoic paleovirus reveals the evolution of hepatitis B viruses (2013) (59)
The myomodulin-related neuropeptides: characterization of a gene encoding a family of peptide cotransmitters in Aplysia (1993) (58)
Retroposon insertions and the chronology of avian sex chromosome evolution. (2011) (58)
The BC200 RNA Gene and Its Neural Expression Are Conserved in Anthropoidea (Primates) (1998) (55)
Multiple Lineages of Ancient CR1 Retroposons Shaped the Early Genome Evolution of Amniotes (2014) (55)
Transport of BC1 RNA in hypothalamo-neurohypophyseal axons (1993) (54)
An ‘internal” signal sequence directs secretion and processing of proinsulin in bacteria (1981) (53)
[41] Compilation of superlinker vectors (1992) (52)
Birth of a gene: locus of neuronal BC200 snmRNA in three prosimians and human BC200 pseudogenes as archives of change in the Anthropoidea lineage. (2001) (50)
Identification and characterization of BC1 RNP particles. (1996) (50)
A novel web-based TinT application and the chronology of the Primate Alu retroposon activity (2010) (49)
MG-160, a membrane sialoglycoprotein of the medial cisternae of the rat Golgi apparatus, binds basic fibroblast growth factor and exhibits a high level of sequence identity to a chicken fibroblast growth factor receptor. (1995) (49)
A novel abundant family of retroposed elements (DAS-SINEs) in the nine-banded armadillo (Dasypus novemcinctus). (2005) (48)
A novel class of mammalian-specific tailless retropseudogenes. (2004) (46)
Retrophylogenomics Place Tarsiers on the Evolutionary Branch of Anthropoids (2013) (46)
Beyond DNA: RNA editing and steps toward Alu exonization in primates. (2008) (46)
Occurrence of methylated amino acids as N-termini of proteins from Escherichia coli ribosomes. (1977) (45)
Modern genomes with retro-look: retrotransposed elements, retroposition and the origin of new genes. (2007) (45)
Two primate-specific small non-protein-coding RNAs in transgenic mice: neuronal expression, subcellular localization and binding partners (2006) (44)
Reverse transcriptase: Mediator of genomic plasticity (2005) (44)
Heterodimer SRP9/14 is an integral part of the neural BC200 RNP in primate brain (1998) (41)
Retroposon insertion patterns of neoavian birds: strong evidence for an extensive incomplete lineage sorting era. (2012) (41)
Expression of neural BC1 RNA: induction in murine tumours. (1997) (41)
Identification of human autoantigen La/SS-B as BC1/BC200 RNA-binding protein. (1998) (40)
On BC1 RNA and the fragile X mental retardation protein (2008) (39)
Plasmids for the selection and analysis of prokaryotic promoters. (1987) (39)
An unusual primate locus that attracted two independent Alu insertions and facilitates their transcription. (2005) (38)
The primary structure of the 5S RNA binding protein L18 from Escherichia coli ribosomes (1975) (37)
BC1 RNA, the transcript from a master gene for ID element amplification, is able to prime its own reverse transcription. (1997) (36)
Rat calmodulin cDNA. (1987) (36)
Clathrin light chain B: gene structure and neuron-specific splicing. (1992) (36)
Molecular cloning and complete amino acid sequence of AP50, an assembly protein associated with clathrin-coated vesicles. (1988) (35)
The Fragmented Gene (2009) (34)
Compilation of superlinker vectors. (1992) (33)
Genome sequence of the basal haplorrhine primate Tarsius syrichta reveals unusual insertions (2016) (33)
Gene duplication and other evolutionary strategies: from the RNA world to the future (2004) (33)
Evolution, expression, and possible function of a master gene for amplification of an interspersed repeated DNA family in rodents. (1996) (32)
Identification of an evolutionarily divergent U11 small nuclear ribonucleoprotein particle in Drosophila. (2004) (31)
Expression vectors employing lambda-, trp-, lac-, and lpp-derived promoters. (1988) (31)
A small RNA in testis and brain: implications for male germ cell development. (2002) (30)
Automated scanning for phylogenetically informative transposed elements in rodents. (2006) (27)
A universal method for the study of CR1 retroposons in nonmodel bird genomes. (2012) (27)
tRNAs in the spotlight during protein biosynthesis. (2001) (26)
Neuronal BC1 RNA: intracellular transport and activity-dependent modulation. (2001) (25)
What is an RNA? A top layer for RNA classification (2016) (25)
Neuronal BC1 RNA: Co-expression with growth-associated protein-43 messenger RNA (2001) (24)
Disparity, adaptation, exaptation, bookkeeping, and contingency at the genome level (2005) (24)
Evidence for a Novel Mechanism of Influenza Virus-Induced Type I Interferon Expression by a Defective RNA-Encoded Protein (2015) (23)
Primary structure of Escherichia coli ribosomal protein L31. (1978) (23)
Expression of dendritic BC200 RNA, component of a 11.4S ribonucleoprotein particle, is conserved in monkey brain (1997) (21)
Maternal transcription of non-protein coding RNAs from the PWS-critical region rescues growth retardation in mice (2016) (21)
How significant is 98.5% 'junk' in mammalian genomes? (2003) (21)
RNomenclature (2004) (20)
Molecular cloning and characterization of the mouse dopamine D3 receptor gene: an additional intron and an mRNA variant. (1995) (18)
Neuronal MAP2 mRNA: species-dependent differential dendritic targeting competence. (2004) (17)
Fragment of protein L18 from the Escherichia coli ribosome that contains the 5S RNA binding site. (1978) (17)
Can ID Repetitive Elements Serve as Cis-acting Dendritic Targeting Elements? An In Vivo Study (2007) (17)
Retroposon insertions provide insights into deep lagomorph evolution. (2010) (17)
Exaptation at the molecular genetic level (2018) (15)
Eugenics—evolutionary nonsense? (2000) (15)
Expression of dendritic BC200 RNA, component of a 11.4S ribonucleoprotein particle, is conserved in humans and simians. (1997) (14)
Isolation and Posttranscriptional Modification Analysis of Native BC1 RNA from Mouse Brain (2007) (14)
Reply to Bagni: On BC1 RNA and the fragile X mental retardation protein (2008) (13)
Molecular Genetic Approaches to Neuropsychiatric Diseases (1991) (12)
The persistent contributions of RNA to eukaryotic gen(om)e architecture and cellular function. (2014) (12)
Ancient Traces of Tailless Retropseudogenes in Therian Genomes (2015) (10)
Molecular constructivity (1993) (10)
DNA sequences flanking an E. coli insertion element IS2 in a cloned yeast TRP5 gene. (1982) (10)
BC1 RNA motifs required for dendritic transport in vivo (2016) (10)
Ancestry of the Australian termitivorous numbat. (2013) (10)
Assignment1 of the human BC200 RNA gene (BCYRN1) to chromosome 2p16 by radiation hybrid mapping (1998) (10)
GPAC-genome presence/absence compiler: a web application to comparatively visualize multiple genome-level changes. (2015) (10)
De-novo emergence of SINE retroposons during the early evolution of passerine birds (2017) (10)
From Eden to a hell of uniformity? Directed evolution in humans. (2003) (10)
Murine BC1 RNA in dendritic fields of the retinal inner plexiform layer (1992) (9)
Sanchored PCR: PCR with cDNA coupled to a solid phase. (1991) (8)
Binding of the S7 Protein with Fragment 926–986/1219–1393 of the 16S rRNA As a Key Step in the Assembly of the Small Subunit of Prokaryotic Ribosomes (2001) (8)
Transcriptional interference by small transcripts in proximal promoter regions (2018) (8)
Does every transcript originate from a gene? (2015) (7)
[Study of the binding of the S7 protein with 16S rRNA fragment 926-986/1219-1393 as a key step in the assembly of the small subunit of prokaryotic ribosomes]. (2001) (7)
Localization of the mouse gene (Bc1) encoding neural BC1 RNA near the fibroblast growth factor 3 locus (Fgf3) on distal chromosome 7. (1997) (7)
Primary structure of protein L19 from the large subunit of Escherichia coli ribosomes. (1978) (7)
Assignment of the human BC200 RNA gene (BCYRN1) to chromosome 2p16 by radiation hybrid mapping. (1998) (7)
RNA towards medicine (2006) (7)
Does the AD7c-NTP locus encode a protein? (2005) (6)
The Volcano Rabbit in the Phylogenetic Network of Lagomorphs (2018) (6)
The 10Sa RNA gene of Thermus thermophilus. (1998) (4)
2 – EXPRESSION VECTORS EMPLOYING THE trc PROMOTER * (1999) (3)
Enhancer occlusion transcripts regulate the activity of human enhancer domains via transcriptional interference: a computational perspective (2020) (2)
Temperature recording from thermocyclers used for PCR. (1991) (2)
Corrigendum: Retrophylogenomics Place Tarsiers on the Evolutionary Branch of Anthropoids (2015) (1)
A tRNA Pseudogene in the Archaeon Methanococcus jannaschii (2000) (1)
Familial Alzheimer's mutation: mRNA secondary structure revisited (1992) (1)
Three-Way Alignments to Analyze the Root of Rodents (2010) (0)
Nucleus? Insights from Photosynthetic Eukaryotes What Was the Real Contribution of Endosymbionts to the Eukaryotic (2014) (0)
BC200 RNA samples derived from and related applications (1994) (0)
BC 200 RNA : A neural RNA polymerase III product encoded by a monomeric Alu element ( recruited retroposon / exaptation / primate-specific / pseudogenes / gene conversion ) (2005) (0)
ExoPLOT: Representation of alternative splicing in human tissues and developmental stages with transposed element (TE) involvement. (2022) (0)
In vivo transcription from deletion mutations introduced near Escherichia coli ribosomal RNA promoter P2 (2004) (0)
lineages of ancient retroposons shaped the early genome evolution of (2015) (0)
Original Paper Expression of Neural BCI RNA: Induction in Murine Tumours (1997) (0)
RNomics Analysis of novel in silico derived non-protein coding RNAs in the human genome (2005) (0)
Erratum: Expression of dendritic BC200 RNA, component of a 11.4S ribonucleoprotein particle, is conserved in humans and simians (Neuroscience Letters PII: S0304394097134711) (1997) (0)
Retroposon Screening from Guinea Pig Genomic and Ground Squirrel Trace Sequences (2010) (0)
Experimental RNomics Detects 36 Novel SnoRNAs in Plasmodium falciparum. (2008) (0)
Small Non-Protein Coding RNA as novel Diagnostic Marker for Infectious Disease. (2008) (0)

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